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Q8WUQ7

- CATIN_HUMAN

UniProt

Q8WUQ7 - CATIN_HUMAN

Protein

Cactin

Gene

CACTIN

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 3 (08 Feb 2011)
      Previous versions | rss
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    Functioni

    Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon-regulatory factor (IRF) signaling pathways. Contributes to the regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli. May play a role during early embryonic development. Probably involved in pre-mRNA splicing.1 Publication

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB
    2. protein binding Source: UniProtKB

    GO - Biological processi

    1. cellular response to interleukin-1 Source: UniProtKB
    2. cellular response to lipopolysaccharide Source: UniProtKB
    3. cellular response to tumor necrosis factor Source: UniProtKB
    4. innate immune response Source: UniProtKB-KW
    5. mRNA splicing, via spliceosome Source: UniProtKB
    6. multicellular organismal development Source: UniProtKB-KW
    7. negative regulation of interferon-beta production Source: UniProtKB
    8. negative regulation of interleukin-8 production Source: UniProtKB
    9. negative regulation of lipopolysaccharide-mediated signaling pathway Source: UniProtKB
    10. negative regulation of NF-kappaB transcription factor activity Source: UniProtKB
    11. negative regulation of protein phosphorylation Source: UniProtKB
    12. negative regulation of toll-like receptor signaling pathway Source: UniProtKB
    13. negative regulation of tumor necrosis factor production Source: UniProtKB
    14. negative regulation of type I interferon-mediated signaling pathway Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Immunity, Innate immunity, mRNA processing, mRNA splicing

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cactin
    Alternative name(s):
    Renal carcinoma antigen NY-REN-24
    Gene namesi
    Name:CACTIN
    Synonyms:C19orf29
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:29938. CACTIN.

    Subcellular locationi

    Nucleus 1 Publication
    Note: Nuclear localization with a speckled expression pattern in some cells. Colocalizes with NFKBIL1 in the nucleus.

    GO - Cellular componenti

    1. catalytic step 2 spliceosome Source: UniProtKB
    2. cytoplasm Source: HPA
    3. extracellular vesicular exosome Source: UniProt
    4. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus, Spliceosome

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134932683.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 758758CactinPRO_0000231617Add
    BLAST

    Proteomic databases

    MaxQBiQ8WUQ7.
    PaxDbiQ8WUQ7.
    PRIDEiQ8WUQ7.

    PTM databases

    PhosphoSiteiQ8WUQ7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8WUQ7.
    BgeeiQ8WUQ7.
    CleanExiHS_C19orf29.
    GenevestigatoriQ8WUQ7.

    Organism-specific databases

    HPAiHPA042504.
    HPA042548.

    Interactioni

    Subunit structurei

    Interacts (via N-terminal domain) with NFKBIL1; the interaction occurs in a proinflammatory-independent manner. Does not interact with RELA NF-kappa-B subunit. Identified in the spliceosome C complex.2 Publications

    Protein-protein interaction databases

    BioGridi121836. 4 interactions.
    IntActiQ8WUQ7. 2 interactions.
    MINTiMINT-4654969.
    STRINGi9606.ENSP00000248420.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8WUQ7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili135 – 18551Sequence AnalysisAdd
    BLAST
    Coiled coili225 – 27753Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi101 – 1077Poly-Arg
    Compositional biasi129 – 1335Poly-Ala

    Sequence similaritiesi

    Belongs to the CACTIN family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG290728.
    HOVERGENiHBG079755.
    InParanoidiQ8WUQ7.
    OrthoDBiEOG7XM2Z3.
    PhylomeDBiQ8WUQ7.
    TreeFamiTF300906.

    Family and domain databases

    InterProiIPR019134. Cactin_C.
    IPR018816. Cactin_dom.
    [Graphical view]
    PfamiPF10312. Cactin_mid. 1 hit.
    PF09732. CactinC_cactus. 1 hit.
    [Graphical view]
    SMARTiSM01050. CactinC_cactus. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8WUQ7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGRDTRSRSR SAGRRGRRRQ SQSGSRSRSR SHGRRNRRRR EDEGRRRRRR    50
    RSRERRSDSE EERWQRSGMR SRSPPRPKWH SRDGSSQSDS GEEQSRGQWA 100
    RRRRRARSWS PSSSASSSAS PGRSQSPRAA AAALSQQQSL QERLRLREER 150
    KQQEELMKAF ETPEEKRARR LAKKEAKERK KREKMGWGEE YMGYTNTDNP 200
    FGDNNLLGTF IWNKALEKKG ISHLEEKELK ERNKRIQEDN RLELQKVKQL 250
    RLEREREKAM REQELEMLQR EKEAEHFKTW EEQEDNFHLQ QAKLRSKIRI 300
    RDGRAKPIDL LAKYISAEDD DLAVEMHEPY TFLNGLTVAD MEDLLEDIQV 350
    YMELEQGKNA DFWRDMTTIT EDEISKLRKL EASGKGPGER REGVNASVSS 400
    DVQSVFKGKT YNQLQVIFQG IEGKIRAGGP NLDMGYWESL LQQLRAHMAR 450
    ARLRERHQDV LRQKLYKLKQ EQGVESEPLF PILKQEPQSP SRSLEPEDAA 500
    PTPPGPSSEG GPAEAEVDGA TPTEGDGDGD GEGEGEGEAV LMEEDLIQQS 550
    LDDYDAGRYS PRLLTAHELP LDAHVLEPDE DLQRLQLSRQ QLQVTGDASE 600
    SAEDIFFRRA KEGMGQDEAQ FSVEMPLTGK AYLWADKYRP RKPRFFNRVH 650
    TGFEWNKYNQ THYDFDNPPP KIVQGYKFNI FYPDLIDKRS TPEYFLEACA 700
    DNKDFAILRF HAGPPYEDIA FKIVNREWEY SHRHGFRCQF ANGIFQLWFH 750
    FKRYRYRR 758

    Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

    Length:758
    Mass (Da):88,702
    Last modified:February 8, 2011 - v3
    Checksum:iF540F151EB96BEFB
    GO
    Isoform 2 (identifier: Q8WUQ7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         758-758: R → RPGPCWRPIR...LAYWQDRMFF

    Note: No experimental confirmation available.

    Show »
    Length:935
    Mass (Da):107,938
    Checksum:iE7238F52D6384E50
    GO

    Sequence cautioni

    The sequence AAD42868.1 differs from that shown. Reason: Frameshift at position 711.
    The sequence AAH04262.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence AAC24305.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence AAC32903.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence EAW69298.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti499 – 4991A → V in AAH19848. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei758 – 7581R → RPGPCWRPIRHCRRDPLWTP TLCRDWPPTHPVLAGGVHFP AAGIPPPGLLTGPWSMRPVT PSFAHIRTVAPSHSPFSGQE GRGPHGCHSPGRSGPAGRLV LQHPTGTSPTEAKRKVPPGP PEGHPTSPVTSPRPPTAPPR HPASSGNSSVCFSKKTCRWE KKSFVLMELAYWQDRMFF in isoform 2. CuratedVSP_017856

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY917150 mRNA. Translation: AAX84551.1.
    AC005175 Genomic DNA. Translation: AAC24305.1. Sequence problems.
    AC005542 Genomic DNA. Translation: AAC32903.1. Sequence problems.
    AF155102 mRNA. Translation: AAD42868.1. Frameshift.
    CH471139 Genomic DNA. Translation: EAW69298.1. Frameshift.
    BC004262 mRNA. Translation: AAH04262.1. Different initiation.
    BC019848 mRNA. Translation: AAH19848.1.
    CCDSiCCDS45920.1. [Q8WUQ7-1]
    PIRiT02672.
    RefSeqiNP_001074012.1. NM_001080543.1. [Q8WUQ7-1]
    NP_067054.1. NM_021231.1. [Q8WUQ7-1]
    UniGeneiHs.128425.

    Genome annotation databases

    EnsembliENST00000248420; ENSP00000248420; ENSG00000105298. [Q8WUQ7-1]
    ENST00000429344; ENSP00000415078; ENSG00000105298. [Q8WUQ7-1]
    ENST00000585942; ENSP00000465751; ENSG00000105298. [Q8WUQ7-1]
    GeneIDi58509.
    KEGGihsa:58509.
    UCSCiuc002lyh.3. human. [Q8WUQ7-1]

    Polymorphism databases

    DMDMi322510133.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY917150 mRNA. Translation: AAX84551.1 .
    AC005175 Genomic DNA. Translation: AAC24305.1 . Sequence problems.
    AC005542 Genomic DNA. Translation: AAC32903.1 . Sequence problems.
    AF155102 mRNA. Translation: AAD42868.1 . Frameshift.
    CH471139 Genomic DNA. Translation: EAW69298.1 . Frameshift.
    BC004262 mRNA. Translation: AAH04262.1 . Different initiation.
    BC019848 mRNA. Translation: AAH19848.1 .
    CCDSi CCDS45920.1. [Q8WUQ7-1 ]
    PIRi T02672.
    RefSeqi NP_001074012.1. NM_001080543.1. [Q8WUQ7-1 ]
    NP_067054.1. NM_021231.1. [Q8WUQ7-1 ]
    UniGenei Hs.128425.

    3D structure databases

    ProteinModelPortali Q8WUQ7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121836. 4 interactions.
    IntActi Q8WUQ7. 2 interactions.
    MINTi MINT-4654969.
    STRINGi 9606.ENSP00000248420.

    PTM databases

    PhosphoSitei Q8WUQ7.

    Polymorphism databases

    DMDMi 322510133.

    Proteomic databases

    MaxQBi Q8WUQ7.
    PaxDbi Q8WUQ7.
    PRIDEi Q8WUQ7.

    Protocols and materials databases

    DNASUi 58509.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000248420 ; ENSP00000248420 ; ENSG00000105298 . [Q8WUQ7-1 ]
    ENST00000429344 ; ENSP00000415078 ; ENSG00000105298 . [Q8WUQ7-1 ]
    ENST00000585942 ; ENSP00000465751 ; ENSG00000105298 . [Q8WUQ7-1 ]
    GeneIDi 58509.
    KEGGi hsa:58509.
    UCSCi uc002lyh.3. human. [Q8WUQ7-1 ]

    Organism-specific databases

    CTDi 58509.
    GeneCardsi GC19M003610.
    H-InvDB HIX0014643.
    HIX0027556.
    HGNCi HGNC:29938. CACTIN.
    HPAi HPA042504.
    HPA042548.
    neXtProti NX_Q8WUQ7.
    PharmGKBi PA134932683.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG290728.
    HOVERGENi HBG079755.
    InParanoidi Q8WUQ7.
    OrthoDBi EOG7XM2Z3.
    PhylomeDBi Q8WUQ7.
    TreeFami TF300906.

    Miscellaneous databases

    GeneWikii C19orf29.
    GenomeRNAii 58509.
    NextBioi 65027.
    PROi Q8WUQ7.

    Gene expression databases

    ArrayExpressi Q8WUQ7.
    Bgeei Q8WUQ7.
    CleanExi HS_C19orf29.
    Genevestigatori Q8WUQ7.

    Family and domain databases

    InterProi IPR019134. Cactin_C.
    IPR018816. Cactin_dom.
    [Graphical view ]
    Pfami PF10312. Cactin_mid. 1 hit.
    PF09732. CactinC_cactus. 1 hit.
    [Graphical view ]
    SMARTi SM01050. CactinC_cactus. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cai Y., Yan Y.
      Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 123-758.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 69-758.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 469-758 (ISOFORM 1).
      Tissue: Cervix and Uterus.
    5. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 534-758 (ISOFORM 1), IDENTIFICATION AS A RENAL CANCER ANTIGEN.
      Tissue: Renal cell carcinoma.
    6. "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis."
      Jurica M.S., Licklider L.J., Gygi S.P., Grigorieff N., Moore M.J.
      RNA 8:426-439(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE SPLICEOSOMAL C COMPLEX.
    7. "Cactin targets the MHC class III protein IkappaB-like (IkappaBL) and inhibits NF-kappaB and interferon-regulatory factor signaling pathways."
      Atzei P., Gargan S., Curran N., Moynagh P.N.
      J. Biol. Chem. 285:36804-36817(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH NFKBIL1, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiCATIN_HUMAN
    AccessioniPrimary (citable) accession number: Q8WUQ7
    Secondary accession number(s): A6NNA9
    , A9UL12, O75229, Q7LE08, Q9BTA6, Q9Y5A4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: February 8, 2011
    Last modified: October 1, 2014
    This is version 106 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Antigen recognized by autologous antibody in patients with renal-cell carcinoma.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3