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Q8WUN7

- UBTD2_HUMAN

UniProt

Q8WUN7 - UBTD2_HUMAN

Protein

Ubiquitin domain-containing protein 2

Gene

UBTD2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 2 (27 Jun 2006)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin domain-containing protein 2
    Alternative name(s):
    Dendritic cell-derived ubiquitin-like protein
    Short name:
    DC-UbP
    Ubiquitin-like protein SB72
    Gene namesi
    Name:UBTD2
    Synonyms:DCUBP
    ORF Names:SB72
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:24463. UBTD2.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162408325.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 234234Ubiquitin domain-containing protein 2PRO_0000244332Add
    BLAST

    Proteomic databases

    MaxQBiQ8WUN7.
    PaxDbiQ8WUN7.
    PRIDEiQ8WUN7.

    PTM databases

    PhosphoSiteiQ8WUN7.

    Expressioni

    Tissue specificityi

    Detected in dendritic cells. Highly expressed in tumor cell lines, but not detectable in most tissues.1 Publication

    Gene expression databases

    ArrayExpressiQ8WUN7.
    BgeeiQ8WUN7.
    CleanExiHS_UBTD2.
    GenevestigatoriQ8WUN7.

    Organism-specific databases

    HPAiHPA035892.

    Interactioni

    Protein-protein interaction databases

    BioGridi124917. 1 interaction.
    STRINGi9606.ENSP00000377381.

    Structurei

    Secondary structure

    1
    234
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi21 – 233
    Helixi47 – 5812
    Helixi68 – 8215
    Helixi86 – 9611
    Beta strandi105 – 1106
    Turni111 – 1133
    Beta strandi114 – 1174
    Helixi120 – 1223
    Turni127 – 1293
    Turni133 – 1353
    Beta strandi151 – 1588
    Turni159 – 1613
    Beta strandi162 – 1687
    Helixi173 – 18311
    Beta strandi193 – 1964
    Helixi206 – 2094
    Beta strandi213 – 2153
    Beta strandi217 – 2215

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1TTNNMR-A129-234[»]
    2KSNNMR-A14-141[»]
    ProteinModelPortaliQ8WUN7.
    SMRiQ8WUN7. Positions 14-141, 149-228.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ8WUN7.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini152 – 22776Ubiquitin-likePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 ubiquitin-like domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG278278.
    HOGENOMiHOG000231205.
    HOVERGENiHBG080179.
    InParanoidiQ8WUN7.
    OMAiMIEEKGD.
    OrthoDBiEOG76HQ27.
    PhylomeDBiQ8WUN7.
    TreeFamiTF323925.

    Family and domain databases

    InterProiIPR000626. Ubiquitin-like.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view]
    PfamiPF00240. ubiquitin. 1 hit.
    [Graphical view]
    SMARTiSM00213. UBQ. 1 hit.
    [Graphical view]
    SUPFAMiSSF54236. SSF54236. 1 hit.
    PROSITEiPS50053. UBIQUITIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8WUN7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGGCVGAQHD SSGSLNENSE GTGVALGRNQ PLKKEKPKWK SDYPMTDGQL    50
    RSKRDEFWDT APAFEGRKEI WDALKAAAHA FESNDHELAQ AIIDGANITL 100
    PHGALTECYD ELGNRYQLPV YCLAPPINMI EEKSDIETLD IPEPPPNSGY 150
    ECQLRLRLST GKDLKLVVRS TDTVFHMKRR LHAAEGVEPG SQRWFFSGRP 200
    LTDKMKFEEL KIPKDYVVQV IVSQPVQNPT PVEN 234
    Length:234
    Mass (Da):26,190
    Last modified:June 27, 2006 - v2
    Checksum:i9FB195CDDE83583E
    GO

    Sequence cautioni

    The sequence AAH19910.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAL99389.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti129 – 1291M → I.
    Corresponds to variant rs17074452 [ dbSNP | Ensembl ].
    VAR_052694

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC008671 Genomic DNA. No translation available.
    AC024561 Genomic DNA. No translation available.
    BC019910 mRNA. Translation: AAH19910.1. Different initiation.
    AF251700 mRNA. Translation: AAL99389.1. Different initiation.
    CCDSiCCDS4379.2.
    RefSeqiNP_689490.2. NM_152277.2.
    XP_005266067.1. XM_005266010.1.
    UniGeneiHs.131570.

    Genome annotation databases

    EnsembliENST00000393792; ENSP00000377381; ENSG00000168246.
    GeneIDi92181.
    KEGGihsa:92181.
    UCSCiuc003mbp.1. human.

    Polymorphism databases

    DMDMi109896149.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC008671 Genomic DNA. No translation available.
    AC024561 Genomic DNA. No translation available.
    BC019910 mRNA. Translation: AAH19910.1 . Different initiation.
    AF251700 mRNA. Translation: AAL99389.1 . Different initiation.
    CCDSi CCDS4379.2.
    RefSeqi NP_689490.2. NM_152277.2.
    XP_005266067.1. XM_005266010.1.
    UniGenei Hs.131570.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1TTN NMR - A 129-234 [» ]
    2KSN NMR - A 14-141 [» ]
    ProteinModelPortali Q8WUN7.
    SMRi Q8WUN7. Positions 14-141, 149-228.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124917. 1 interaction.
    STRINGi 9606.ENSP00000377381.

    PTM databases

    PhosphoSitei Q8WUN7.

    Polymorphism databases

    DMDMi 109896149.

    Proteomic databases

    MaxQBi Q8WUN7.
    PaxDbi Q8WUN7.
    PRIDEi Q8WUN7.

    Protocols and materials databases

    DNASUi 92181.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000393792 ; ENSP00000377381 ; ENSG00000168246 .
    GeneIDi 92181.
    KEGGi hsa:92181.
    UCSCi uc003mbp.1. human.

    Organism-specific databases

    CTDi 92181.
    GeneCardsi GC05M171573.
    HGNCi HGNC:24463. UBTD2.
    HPAi HPA035892.
    MIMi 610174. gene.
    neXtProti NX_Q8WUN7.
    PharmGKBi PA162408325.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG278278.
    HOGENOMi HOG000231205.
    HOVERGENi HBG080179.
    InParanoidi Q8WUN7.
    OMAi MIEEKGD.
    OrthoDBi EOG76HQ27.
    PhylomeDBi Q8WUN7.
    TreeFami TF323925.

    Miscellaneous databases

    ChiTaRSi UBTD2. human.
    EvolutionaryTracei Q8WUN7.
    GenomeRNAii 92181.
    NextBioi 77626.
    PROi Q8WUN7.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8WUN7.
    Bgeei Q8WUN7.
    CleanExi HS_UBTD2.
    Genevestigatori Q8WUN7.

    Family and domain databases

    InterProi IPR000626. Ubiquitin-like.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view ]
    Pfami PF00240. ubiquitin. 1 hit.
    [Graphical view ]
    SMARTi SM00213. UBQ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54236. SSF54236. 1 hit.
    PROSITEi PS50053. UBIQUITIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 10-234.
      Tissue: Mammary gland.
    3. "Cloning and identification of a novel human ubiquitin-like protein, DC-UbP, from dendritic cells."
      Liu S., An H., Li N., Yu Y., Lin N., Wan T., Zhang M., Wang W., Cao X.
      Biochem. Biophys. Res. Commun. 300:800-805(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 122-234, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Tissue: Dendritic cell.
    4. "Solution structure of the ubiquitin-like domain of human DC-UbP from dendritic cells."
      Gao Y.-G., Song A.-X., Shi Y.-H., Chang Y.-G., Liu S.-X., Yu Y.-Z., Cao X.-T., Lin D.-H., Hu H.-Y.
      Protein Sci. 14:2044-2050(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 129-234.

    Entry informationi

    Entry nameiUBTD2_HUMAN
    AccessioniPrimary (citable) accession number: Q8WUN7
    Secondary accession number(s): Q8TDQ3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2006
    Last sequence update: June 27, 2006
    Last modified: October 1, 2014
    This is version 91 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3