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Protein

Ubiquitin domain-containing protein 2

Gene

UBTD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin domain-containing protein 2
Alternative name(s):
Dendritic cell-derived ubiquitin-like protein
Short name:
DC-UbP
Ubiquitin-like protein SB72
Gene namesi
Name:UBTD2
Synonyms:DCUBP
ORF Names:SB72
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:24463. UBTD2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000168246.
PharmGKBiPA162408325.

Polymorphism and mutation databases

BioMutaiUBTD2.
DMDMi109896149.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002443321 – 234Ubiquitin domain-containing protein 2Add BLAST234

Proteomic databases

EPDiQ8WUN7.
MaxQBiQ8WUN7.
PaxDbiQ8WUN7.
PeptideAtlasiQ8WUN7.
PRIDEiQ8WUN7.

PTM databases

iPTMnetiQ8WUN7.
PhosphoSitePlusiQ8WUN7.
SwissPalmiQ8WUN7.

Expressioni

Tissue specificityi

Detected in dendritic cells. Highly expressed in tumor cell lines, but not detectable in most tissues.1 Publication

Gene expression databases

BgeeiENSG00000168246.
CleanExiHS_UBTD2.
GenevisibleiQ8WUN7. HS.

Organism-specific databases

HPAiHPA035891.
HPA035892.

Interactioni

Protein-protein interaction databases

BioGridi124917. 13 interactors.
STRINGi9606.ENSP00000377381.

Structurei

Secondary structure

1234
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi21 – 23Combined sources3
Helixi47 – 58Combined sources12
Helixi68 – 82Combined sources15
Helixi86 – 96Combined sources11
Beta strandi105 – 110Combined sources6
Turni111 – 113Combined sources3
Beta strandi114 – 117Combined sources4
Helixi120 – 122Combined sources3
Turni127 – 129Combined sources3
Turni133 – 135Combined sources3
Beta strandi151 – 158Combined sources8
Turni159 – 161Combined sources3
Beta strandi162 – 168Combined sources7
Helixi173 – 183Combined sources11
Beta strandi193 – 196Combined sources4
Helixi206 – 209Combined sources4
Beta strandi213 – 215Combined sources3
Beta strandi217 – 221Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1TTNNMR-A129-234[»]
2KSNNMR-A14-141[»]
ProteinModelPortaliQ8WUN7.
SMRiQ8WUN7.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8WUN7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini152 – 227Ubiquitin-likePROSITE-ProRule annotationAdd BLAST76

Sequence similaritiesi

Contains 1 ubiquitin-like domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0013. Eukaryota.
ENOG410XRPV. LUCA.
GeneTreeiENSGT00390000006816.
HOGENOMiHOG000231205.
HOVERGENiHBG080179.
InParanoidiQ8WUN7.
OMAiMIEEKGD.
OrthoDBiEOG091G0FKF.
PhylomeDBiQ8WUN7.
TreeFamiTF323925.

Family and domain databases

InterProiIPR032752. UBD.
IPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
[Graphical view]
PfamiPF16455. UBD. 1 hit.
PF00240. ubiquitin. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50053. UBIQUITIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WUN7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGCVGAQHD SSGSLNENSE GTGVALGRNQ PLKKEKPKWK SDYPMTDGQL
60 70 80 90 100
RSKRDEFWDT APAFEGRKEI WDALKAAAHA FESNDHELAQ AIIDGANITL
110 120 130 140 150
PHGALTECYD ELGNRYQLPV YCLAPPINMI EEKSDIETLD IPEPPPNSGY
160 170 180 190 200
ECQLRLRLST GKDLKLVVRS TDTVFHMKRR LHAAEGVEPG SQRWFFSGRP
210 220 230
LTDKMKFEEL KIPKDYVVQV IVSQPVQNPT PVEN
Length:234
Mass (Da):26,190
Last modified:June 27, 2006 - v2
Checksum:i9FB195CDDE83583E
GO

Sequence cautioni

The sequence AAH19910 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAL99389 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052694129M → I.Corresponds to variant rs17074452dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008671 Genomic DNA. No translation available.
AC024561 Genomic DNA. No translation available.
BC019910 mRNA. Translation: AAH19910.1. Different initiation.
AF251700 mRNA. Translation: AAL99389.1. Different initiation.
CCDSiCCDS4379.2.
RefSeqiNP_689490.2. NM_152277.2.
XP_016865511.1. XM_017010022.1.
XP_016865512.1. XM_017010023.1.
UniGeneiHs.131570.

Genome annotation databases

EnsembliENST00000393792; ENSP00000377381; ENSG00000168246.
GeneIDi92181.
KEGGihsa:92181.
UCSCiuc003mbp.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008671 Genomic DNA. No translation available.
AC024561 Genomic DNA. No translation available.
BC019910 mRNA. Translation: AAH19910.1. Different initiation.
AF251700 mRNA. Translation: AAL99389.1. Different initiation.
CCDSiCCDS4379.2.
RefSeqiNP_689490.2. NM_152277.2.
XP_016865511.1. XM_017010022.1.
XP_016865512.1. XM_017010023.1.
UniGeneiHs.131570.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1TTNNMR-A129-234[»]
2KSNNMR-A14-141[»]
ProteinModelPortaliQ8WUN7.
SMRiQ8WUN7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124917. 13 interactors.
STRINGi9606.ENSP00000377381.

PTM databases

iPTMnetiQ8WUN7.
PhosphoSitePlusiQ8WUN7.
SwissPalmiQ8WUN7.

Polymorphism and mutation databases

BioMutaiUBTD2.
DMDMi109896149.

Proteomic databases

EPDiQ8WUN7.
MaxQBiQ8WUN7.
PaxDbiQ8WUN7.
PeptideAtlasiQ8WUN7.
PRIDEiQ8WUN7.

Protocols and materials databases

DNASUi92181.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000393792; ENSP00000377381; ENSG00000168246.
GeneIDi92181.
KEGGihsa:92181.
UCSCiuc003mbp.2. human.

Organism-specific databases

CTDi92181.
GeneCardsiUBTD2.
HGNCiHGNC:24463. UBTD2.
HPAiHPA035891.
HPA035892.
MIMi610174. gene.
neXtProtiNX_Q8WUN7.
OpenTargetsiENSG00000168246.
PharmGKBiPA162408325.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0013. Eukaryota.
ENOG410XRPV. LUCA.
GeneTreeiENSGT00390000006816.
HOGENOMiHOG000231205.
HOVERGENiHBG080179.
InParanoidiQ8WUN7.
OMAiMIEEKGD.
OrthoDBiEOG091G0FKF.
PhylomeDBiQ8WUN7.
TreeFamiTF323925.

Miscellaneous databases

ChiTaRSiUBTD2. human.
EvolutionaryTraceiQ8WUN7.
GenomeRNAii92181.
PROiQ8WUN7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000168246.
CleanExiHS_UBTD2.
GenevisibleiQ8WUN7. HS.

Family and domain databases

InterProiIPR032752. UBD.
IPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
[Graphical view]
PfamiPF16455. UBD. 1 hit.
PF00240. ubiquitin. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50053. UBIQUITIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUBTD2_HUMAN
AccessioniPrimary (citable) accession number: Q8WUN7
Secondary accession number(s): Q8TDQ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: November 2, 2016
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.