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Protein

Ubiquitin domain-containing protein 2

Gene

UBTD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin domain-containing protein 2
Alternative name(s):
Dendritic cell-derived ubiquitin-like protein
Short name:
DC-UbP
Ubiquitin-like protein SB72
Gene namesi
Name:UBTD2
Synonyms:DCUBP
ORF Names:SB72
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000168246.5
HGNCiHGNC:24463 UBTD2
MIMi610174 gene
neXtProtiNX_Q8WUN7

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000168246
PharmGKBiPA162408325

Polymorphism and mutation databases

BioMutaiUBTD2
DMDMi109896149

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002443321 – 234Ubiquitin domain-containing protein 2Add BLAST234

Proteomic databases

EPDiQ8WUN7
MaxQBiQ8WUN7
PaxDbiQ8WUN7
PeptideAtlasiQ8WUN7
PRIDEiQ8WUN7

PTM databases

iPTMnetiQ8WUN7
PhosphoSitePlusiQ8WUN7
SwissPalmiQ8WUN7

Expressioni

Tissue specificityi

Detected in dendritic cells. Highly expressed in tumor cell lines, but not detectable in most tissues.1 Publication

Gene expression databases

BgeeiENSG00000168246
CleanExiHS_UBTD2
GenevisibleiQ8WUN7 HS

Organism-specific databases

HPAiHPA035891
HPA035892

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TRIB3Q96RU74EBI-12867288,EBI-492476

GO - Molecular functioni

Protein-protein interaction databases

BioGridi124917, 13 interactors
IntActiQ8WUN7, 9 interactors
STRINGi9606.ENSP00000377381

Structurei

Secondary structure

1234
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi21 – 23Combined sources3
Helixi47 – 58Combined sources12
Helixi68 – 82Combined sources15
Helixi86 – 96Combined sources11
Beta strandi105 – 110Combined sources6
Turni111 – 113Combined sources3
Beta strandi114 – 117Combined sources4
Helixi120 – 122Combined sources3
Turni127 – 129Combined sources3
Turni133 – 135Combined sources3
Beta strandi151 – 158Combined sources8
Turni159 – 161Combined sources3
Beta strandi162 – 168Combined sources7
Helixi173 – 183Combined sources11
Beta strandi193 – 196Combined sources4
Helixi206 – 209Combined sources4
Beta strandi213 – 215Combined sources3
Beta strandi217 – 221Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1TTNNMR-A129-234[»]
2KSNNMR-A14-141[»]
ProteinModelPortaliQ8WUN7
SMRiQ8WUN7
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8WUN7

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini152 – 227Ubiquitin-likePROSITE-ProRule annotationAdd BLAST76

Phylogenomic databases

eggNOGiKOG0013 Eukaryota
ENOG410XRPV LUCA
GeneTreeiENSGT00390000006816
HOGENOMiHOG000231205
HOVERGENiHBG080179
InParanoidiQ8WUN7
OMAiGHECQLR
OrthoDBiEOG091G0FKF
PhylomeDBiQ8WUN7
TreeFamiTF323925

Family and domain databases

Gene3Di1.20.225.20, 1 hit
InterProiView protein in InterPro
IPR032752 DC-UbP/UBTD2_N
IPR038169 DC-UbP/UBTD2_N_sf
IPR029071 Ubiquitin-like_domsf
IPR000626 Ubiquitin_dom
PfamiView protein in Pfam
PF16455 UBD, 1 hit
PF00240 ubiquitin, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50053 UBIQUITIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8WUN7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGCVGAQHD SSGSLNENSE GTGVALGRNQ PLKKEKPKWK SDYPMTDGQL
60 70 80 90 100
RSKRDEFWDT APAFEGRKEI WDALKAAAHA FESNDHELAQ AIIDGANITL
110 120 130 140 150
PHGALTECYD ELGNRYQLPV YCLAPPINMI EEKSDIETLD IPEPPPNSGY
160 170 180 190 200
ECQLRLRLST GKDLKLVVRS TDTVFHMKRR LHAAEGVEPG SQRWFFSGRP
210 220 230
LTDKMKFEEL KIPKDYVVQV IVSQPVQNPT PVEN
Length:234
Mass (Da):26,190
Last modified:June 27, 2006 - v2
Checksum:i9FB195CDDE83583E
GO

Sequence cautioni

The sequence AAH19910 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAL99389 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052694129M → I. Corresponds to variant dbSNP:rs17074452Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008671 Genomic DNA No translation available.
AC024561 Genomic DNA No translation available.
BC019910 mRNA Translation: AAH19910.1 Different initiation.
AF251700 mRNA Translation: AAL99389.1 Different initiation.
CCDSiCCDS4379.2
RefSeqiNP_689490.2, NM_152277.2
XP_016865511.1, XM_017010022.1
XP_016865512.1, XM_017010023.1
UniGeneiHs.131570

Genome annotation databases

EnsembliENST00000393792; ENSP00000377381; ENSG00000168246
GeneIDi92181
KEGGihsa:92181
UCSCiuc003mbp.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiUBTD2_HUMAN
AccessioniPrimary (citable) accession number: Q8WUN7
Secondary accession number(s): Q8TDQ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: May 23, 2018
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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