Q8WUN7 (UBTD2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ubiquitin domain-containing protein 2

Alternative name(s):
Dendritic cell-derived ubiquitin-like protein
Short name=DC-UbP
Ubiquitin-like protein SB72

Gene names

Name:	UBTD2
Synonyms:	DCUBP
ORF Names:	SB72

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	234 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Cytoplasm Ref.3.
Tissue specificity	Detected in dendritic cells. Highly expressed in tumor cell lines, but not detectable in most tissues. Ref.3
Sequence similarities	Contains 1 ubiquitin-like domain.
Sequence caution	The sequence AAH19910.1 differs from that shown. Reason: Erroneous initiation. The sequence AAL99389.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Polymorphism
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from direct assay. Source: HPA nucleus Inferred from direct assay. Source: HPA
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 234

234

Ubiquitin domain-containing protein 2

PRO_0000244332

Regions

Domain

152 – 227

76

Ubiquitin-like

Natural variations

Natural variant

129

1

M → I.
Corresponds to variant rs17074452 [ dbSNP | Ensembl ].

VAR_052694

Secondary structure

1

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234

Helix Strand Turn

Details...

Beta strand

21 – 23

3

Helix

47 – 58

12

Helix

68 – 82

15

Helix

86 – 96

11

Beta strand

105 – 110

6

Turn

111 – 113

3

Beta strand

114 – 117

4

Helix

120 – 122

3

Turn

127 – 129

3

Turn

133 – 135

3

Beta strand

151 – 158

8

Turn

159 – 161

3

Beta strand

162 – 168

7

Helix

173 – 183

11

Beta strand

193 – 196

4

Helix

206 – 209

4

Beta strand

213 – 215

3

Beta strand

217 – 221

5

Sequences

	Sequence		Length	Mass (Da)
	Q8WUN7 [UniParc]. Last modified June 27, 2006. Version 2. Checksum: 9FB195CDDE83583E	FASTA	234	26,190
	10 20 30 40 50 60 MGGCVGAQHD SSGSLNENSE GTGVALGRNQ PLKKEKPKWK SDYPMTDGQL RSKRDEFWDT 70 80 90 100 110 120 APAFEGRKEI WDALKAAAHA FESNDHELAQ AIIDGANITL PHGALTECYD ELGNRYQLPV 130 140 150 160 170 180 YCLAPPINMI EEKSDIETLD IPEPPPNSGY ECQLRLRLST GKDLKLVVRS TDTVFHMKRR 190 200 210 220 230 LHAAEGVEPG SQRWFFSGRP LTDKMKFEEL KIPKDYVVQV IVSQPVQNPT PVEN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence and comparative analysis of human chromosome 5." Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M. Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 10-234. Tissue: Mammary gland.
[3]	"Cloning and identification of a novel human ubiquitin-like protein, DC-UbP, from dendritic cells." Liu S., An H., Li N., Yu Y., Lin N., Wan T., Zhang M., Wang W., Cao X. Biochem. Biophys. Res. Commun. 300:800-805(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 122-234, SUBCELLULAR LOCATION, TISSUE SPECIFICITY. Tissue: Dendritic cell.
[4]	"Solution structure of the ubiquitin-like domain of human DC-UbP from dendritic cells." Gao Y.-G., Song A.-X., Shi Y.-H., Chang Y.-G., Liu S.-X., Yu Y.-Z., Cao X.-T., Lin D.-H., Hu H.-Y. Protein Sci. 14:2044-2050(2005) [PubMed] [Europe PMC] [Abstract] Cited for: STRUCTURE BY NMR OF 129-234.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AC008671 Genomic DNA. No translation available.
AC024561 Genomic DNA. No translation available.
BC019910 mRNA. Translation: AAH19910.1. Different initiation.
AF251700 mRNA. Translation: AAL99389.1. Different initiation.

IPI

IPI00157729.

RefSeq

NP_689490.2. NM_152277.2.

UniGene

Hs.131570.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1TTN	NMR	-	A	129-234	[»]
2KSN	NMR	-	A	14-141	[»]

ProteinModelPortal

Q8WUN7.

ModBase

Search...

Protein-protein interaction databases

STRING

9606.ENSP00000377381.

PTM databases

PhosphoSite

Q8WUN7.

Polymorphism databases

DMDM

109896149.

Proteomic databases

PaxDb

Q8WUN7.

PRIDE

Q8WUN7.

Protocols and materials databases

DNASU

92181.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000393792; ENSP00000377381; ENSG00000168246.

GeneID

92181.

KEGG

hsa:92181.

UCSC

uc003mbp.1. human.

Organism-specific databases

CTD

92181.

GeneCards

GC05M171573.

HGNC

HGNC:24463. UBTD2.

HPA

HPA035892.

MIM

610174. gene.

neXtProt

NX_Q8WUN7.

PharmGKB

PA162408325.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG278278.

HOGENOM

HOG000231205.

HOVERGEN

HBG080179.

InParanoid

Q8WUN7.

OMA

GRPLADK.

OrthoDB

EOG4V9TRK.

Gene expression databases

ArrayExpress

Q8WUN7.

Bgee

Q8WUN7.

CleanEx

HS_UBTD2.

Genevestigator

Q8WUN7.

GermOnline

ENSG00000168246. Homo sapiens.

Family and domain databases

InterPro

IPR000626. Ubiquitin.
IPR019955. Ubiquitin_supergroup.
[Graphical view]

Pfam

PF00240. ubiquitin. 1 hit.
[Graphical view]

SMART

SM00213. UBQ. 1 hit.
[Graphical view]

PROSITE

PS00299. UBIQUITIN_1. False negative.
PS50053. UBIQUITIN_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

UBTD2. human.

EvolutionaryTrace

Q8WUN7.

GenomeRNAi

92181.

NextBio

77626.

SOURCE

Search...

Entry information

Entry name

UBTD2_HUMAN

Accession

Primary (citable) accession number: Q8WUN7
Secondary accession number(s): Q8TDQ3

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	June 27, 2006
Last modified:	May 1, 2013
This is version 79 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.