Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ubiquitin domain-containing protein 2

Gene

UBTD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin domain-containing protein 2
Alternative name(s):
Dendritic cell-derived ubiquitin-like protein
Short name:
DC-UbP
Ubiquitin-like protein SB72
Gene namesi
Name:UBTD2
Synonyms:DCUBP
ORF Names:SB72
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:24463. UBTD2.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162408325.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 234234Ubiquitin domain-containing protein 2PRO_0000244332Add
BLAST

Proteomic databases

MaxQBiQ8WUN7.
PaxDbiQ8WUN7.
PRIDEiQ8WUN7.

PTM databases

PhosphoSiteiQ8WUN7.

Expressioni

Tissue specificityi

Detected in dendritic cells. Highly expressed in tumor cell lines, but not detectable in most tissues.1 Publication

Gene expression databases

BgeeiQ8WUN7.
CleanExiHS_UBTD2.
ExpressionAtlasiQ8WUN7. baseline and differential.
GenevestigatoriQ8WUN7.

Organism-specific databases

HPAiHPA035892.

Interactioni

Protein-protein interaction databases

BioGridi124917. 8 interactions.
STRINGi9606.ENSP00000377381.

Structurei

Secondary structure

1
234
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi21 – 233Combined sources
Helixi47 – 5812Combined sources
Helixi68 – 8215Combined sources
Helixi86 – 9611Combined sources
Beta strandi105 – 1106Combined sources
Turni111 – 1133Combined sources
Beta strandi114 – 1174Combined sources
Helixi120 – 1223Combined sources
Turni127 – 1293Combined sources
Turni133 – 1353Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1TTNNMR-A129-234[»]
2KSNNMR-A14-141[»]
ProteinModelPortaliQ8WUN7.
SMRiQ8WUN7. Positions 14-141, 149-228.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8WUN7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini152 – 22776Ubiquitin-likePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ubiquitin-like domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG278278.
GeneTreeiENSGT00390000006816.
HOGENOMiHOG000231205.
HOVERGENiHBG080179.
InParanoidiQ8WUN7.
OMAiMIEEKGD.
OrthoDBiEOG76HQ27.
PhylomeDBiQ8WUN7.
TreeFamiTF323925.

Family and domain databases

InterProiIPR000626. Ubiquitin-like.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF00240. ubiquitin. 1 hit.
[Graphical view]
SMARTiSM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50053. UBIQUITIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WUN7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGGCVGAQHD SSGSLNENSE GTGVALGRNQ PLKKEKPKWK SDYPMTDGQL
60 70 80 90 100
RSKRDEFWDT APAFEGRKEI WDALKAAAHA FESNDHELAQ AIIDGANITL
110 120 130 140 150
PHGALTECYD ELGNRYQLPV YCLAPPINMI EEKSDIETLD IPEPPPNSGY
160 170 180 190 200
ECQLRLRLST GKDLKLVVRS TDTVFHMKRR LHAAEGVEPG SQRWFFSGRP
210 220 230
LTDKMKFEEL KIPKDYVVQV IVSQPVQNPT PVEN
Length:234
Mass (Da):26,190
Last modified:June 27, 2006 - v2
Checksum:i9FB195CDDE83583E
GO

Sequence cautioni

The sequence AAH19910.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAL99389.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti129 – 1291M → I.
Corresponds to variant rs17074452 [ dbSNP | Ensembl ].
VAR_052694

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008671 Genomic DNA. No translation available.
AC024561 Genomic DNA. No translation available.
BC019910 mRNA. Translation: AAH19910.1. Different initiation.
AF251700 mRNA. Translation: AAL99389.1. Different initiation.
CCDSiCCDS4379.2.
RefSeqiNP_689490.2. NM_152277.2.
XP_005266067.1. XM_005266010.1.
UniGeneiHs.131570.

Genome annotation databases

EnsembliENST00000393792; ENSP00000377381; ENSG00000168246.
GeneIDi92181.
KEGGihsa:92181.
UCSCiuc003mbp.1. human.

Polymorphism databases

DMDMi109896149.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008671 Genomic DNA. No translation available.
AC024561 Genomic DNA. No translation available.
BC019910 mRNA. Translation: AAH19910.1. Different initiation.
AF251700 mRNA. Translation: AAL99389.1. Different initiation.
CCDSiCCDS4379.2.
RefSeqiNP_689490.2. NM_152277.2.
XP_005266067.1. XM_005266010.1.
UniGeneiHs.131570.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1TTNNMR-A129-234[»]
2KSNNMR-A14-141[»]
ProteinModelPortaliQ8WUN7.
SMRiQ8WUN7. Positions 14-141, 149-228.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124917. 8 interactions.
STRINGi9606.ENSP00000377381.

PTM databases

PhosphoSiteiQ8WUN7.

Polymorphism databases

DMDMi109896149.

Proteomic databases

MaxQBiQ8WUN7.
PaxDbiQ8WUN7.
PRIDEiQ8WUN7.

Protocols and materials databases

DNASUi92181.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000393792; ENSP00000377381; ENSG00000168246.
GeneIDi92181.
KEGGihsa:92181.
UCSCiuc003mbp.1. human.

Organism-specific databases

CTDi92181.
GeneCardsiGC05M171573.
HGNCiHGNC:24463. UBTD2.
HPAiHPA035892.
MIMi610174. gene.
neXtProtiNX_Q8WUN7.
PharmGKBiPA162408325.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG278278.
GeneTreeiENSGT00390000006816.
HOGENOMiHOG000231205.
HOVERGENiHBG080179.
InParanoidiQ8WUN7.
OMAiMIEEKGD.
OrthoDBiEOG76HQ27.
PhylomeDBiQ8WUN7.
TreeFamiTF323925.

Miscellaneous databases

ChiTaRSiUBTD2. human.
EvolutionaryTraceiQ8WUN7.
GenomeRNAii92181.
NextBioi77626.
PROiQ8WUN7.
SOURCEiSearch...

Gene expression databases

BgeeiQ8WUN7.
CleanExiHS_UBTD2.
ExpressionAtlasiQ8WUN7. baseline and differential.
GenevestigatoriQ8WUN7.

Family and domain databases

InterProiIPR000626. Ubiquitin-like.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF00240. ubiquitin. 1 hit.
[Graphical view]
SMARTiSM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50053. UBIQUITIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 10-234.
    Tissue: Mammary gland.
  3. "Cloning and identification of a novel human ubiquitin-like protein, DC-UbP, from dendritic cells."
    Liu S., An H., Li N., Yu Y., Lin N., Wan T., Zhang M., Wang W., Cao X.
    Biochem. Biophys. Res. Commun. 300:800-805(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 122-234, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Dendritic cell.
  4. "Solution structure of the ubiquitin-like domain of human DC-UbP from dendritic cells."
    Gao Y.-G., Song A.-X., Shi Y.-H., Chang Y.-G., Liu S.-X., Yu Y.-Z., Cao X.-T., Lin D.-H., Hu H.-Y.
    Protein Sci. 14:2044-2050(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 129-234.

Entry informationi

Entry nameiUBTD2_HUMAN
AccessioniPrimary (citable) accession number: Q8WUN7
Secondary accession number(s): Q8TDQ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: February 4, 2015
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.