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Q8WUN7 (UBTD2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin domain-containing protein 2
Alternative name(s):
Dendritic cell-derived ubiquitin-like protein
Short name=DC-UbP
Ubiquitin-like protein SB72
Gene names
Name:UBTD2
Synonyms:DCUBP
ORF Names:SB72
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length234 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Cytoplasm Ref.3.

Tissue specificity

Detected in dendritic cells. Highly expressed in tumor cell lines, but not detectable in most tissues. Ref.3

Sequence similarities

Contains 1 ubiquitin-like domain.

Sequence caution

The sequence AAH19910.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAL99389.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentCytoplasm
   Coding sequence diversityPolymorphism
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 234234Ubiquitin domain-containing protein 2
PRO_0000244332

Regions

Domain152 – 22776Ubiquitin-like

Natural variations

Natural variant1291M → I.
Corresponds to variant rs17074452 [ dbSNP | Ensembl ].
VAR_052694

Secondary structure

................................. 234
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q8WUN7 [UniParc].

Last modified June 27, 2006. Version 2.
Checksum: 9FB195CDDE83583E

FASTA23426,190
        10         20         30         40         50         60 
MGGCVGAQHD SSGSLNENSE GTGVALGRNQ PLKKEKPKWK SDYPMTDGQL RSKRDEFWDT 

        70         80         90        100        110        120 
APAFEGRKEI WDALKAAAHA FESNDHELAQ AIIDGANITL PHGALTECYD ELGNRYQLPV 

       130        140        150        160        170        180 
YCLAPPINMI EEKSDIETLD IPEPPPNSGY ECQLRLRLST GKDLKLVVRS TDTVFHMKRR 

       190        200        210        220        230 
LHAAEGVEPG SQRWFFSGRP LTDKMKFEEL KIPKDYVVQV IVSQPVQNPT PVEN 

« Hide

References

« Hide 'large scale' references
[1]"The DNA sequence and comparative analysis of human chromosome 5."
Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. expand/collapse author list , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 10-234.
Tissue: Mammary gland.
[3]"Cloning and identification of a novel human ubiquitin-like protein, DC-UbP, from dendritic cells."
Liu S., An H., Li N., Yu Y., Lin N., Wan T., Zhang M., Wang W., Cao X.
Biochem. Biophys. Res. Commun. 300:800-805(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 122-234, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
Tissue: Dendritic cell.
[4]"Solution structure of the ubiquitin-like domain of human DC-UbP from dendritic cells."
Gao Y.-G., Song A.-X., Shi Y.-H., Chang Y.-G., Liu S.-X., Yu Y.-Z., Cao X.-T., Lin D.-H., Hu H.-Y.
Protein Sci. 14:2044-2050(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: STRUCTURE BY NMR OF 129-234.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC008671 Genomic DNA. No translation available.
AC024561 Genomic DNA. No translation available.
BC019910 mRNA. Translation: AAH19910.1. Different initiation.
AF251700 mRNA. Translation: AAL99389.1. Different initiation.
CCDSCCDS4379.2.
RefSeqNP_689490.2. NM_152277.2.
XP_005266067.1. XM_005266010.1.
UniGeneHs.131570.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1TTNNMR-A129-234[»]
2KSNNMR-A14-141[»]
ProteinModelPortalQ8WUN7.
SMRQ8WUN7. Positions 14-141, 149-228.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid124917. 1 interaction.
STRING9606.ENSP00000377381.

PTM databases

PhosphoSiteQ8WUN7.

Polymorphism databases

DMDM109896149.

Proteomic databases

MaxQBQ8WUN7.
PaxDbQ8WUN7.
PRIDEQ8WUN7.

Protocols and materials databases

DNASU92181.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000393792; ENSP00000377381; ENSG00000168246.
GeneID92181.
KEGGhsa:92181.
UCSCuc003mbp.1. human.

Organism-specific databases

CTD92181.
GeneCardsGC05M171573.
HGNCHGNC:24463. UBTD2.
HPAHPA035892.
MIM610174. gene.
neXtProtNX_Q8WUN7.
PharmGKBPA162408325.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG278278.
HOGENOMHOG000231205.
HOVERGENHBG080179.
InParanoidQ8WUN7.
OMAMIEEKGD.
OrthoDBEOG76HQ27.
PhylomeDBQ8WUN7.
TreeFamTF323925.

Gene expression databases

ArrayExpressQ8WUN7.
BgeeQ8WUN7.
CleanExHS_UBTD2.
GenevestigatorQ8WUN7.

Family and domain databases

InterProIPR000626. Ubiquitin-like.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamPF00240. ubiquitin. 1 hit.
[Graphical view]
SMARTSM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMSSF54236. SSF54236. 1 hit.
PROSITEPS50053. UBIQUITIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSUBTD2. human.
EvolutionaryTraceQ8WUN7.
GenomeRNAi92181.
NextBio77626.
PROQ8WUN7.
SOURCESearch...

Entry information

Entry nameUBTD2_HUMAN
AccessionPrimary (citable) accession number: Q8WUN7
Secondary accession number(s): Q8TDQ3
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: July 9, 2014
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM