Q8WUM0 (NU133_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nuclear pore complex protein Nup133

Alternative name(s):
133 kDa nucleoporin
Nucleoporin Nup133

Gene names

Name:

NUP133

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1156 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in poly(A)+ RNA transport. Ref.5
Subunit structure	Forms part of the Nup160 subcomplex in the nuclear pore which is composed of NUP160, NUP133, NUP107 and Nup96. This complex plays a role in RNA export and in tethering Nup98 and NUP153 to the nucleus. Ref.4 Ref.5
Subcellular location	Nucleus › nuclear pore complex. Chromosome › centromere › kinetochore. Note: Located on both the cytoplasmic and nuclear sides of the nuclear pore. During mitosis, localizes to the kinetochores. Ref.4 Ref.5
Sequence similarities	Belongs to the nucleoporin Nup133 family.
Sequence caution	The sequence BAA91885.1 differs from that shown. Reason: Erroneous initiation. The sequence BAB14106.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Protein transport Translocation Transport mRNA transport
Cellular component	Centromere Chromosome Kinetochore Nuclear pore complex Nucleus
Coding sequence diversity	Polymorphism
PTM	Acetylation Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	carbohydrate metabolic process Traceable author statement. Source: Reactome cytokine-mediated signaling pathway Traceable author statement. Source: Reactome glucose transport Traceable author statement. Source: Reactome mRNA export from nucleus Inferred from direct assay Ref.5. Source: UniProtKB mitotic prometaphase Traceable author statement. Source: Reactome nuclear pore organization Inferred from mutant phenotype PubMed 15146057. Source: UniProtKB paraxial mesoderm development Inferred from electronic annotation. Source: Compara protein transport Inferred from electronic annotation. Source: UniProtKB-KW regulation of glucose transport Traceable author statement. Source: Reactome small molecule metabolic process Traceable author statement. Source: Reactome transmembrane transport Traceable author statement. Source: Reactome viral reproduction Traceable author statement. Source: Reactome
Cellular_component	condensed chromosome kinetochore Inferred from electronic annotation. Source: UniProtKB-SubCell cytosol Traceable author statement. Source: Reactome nuclear pore outer ring Inferred from direct assay PubMed 15146057PubMed 17360435. Source: UniProtKB
Molecular_function	nucleocytoplasmic transporter activity Inferred from direct assay Ref.5. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
NUP107	P57740	5	EBI-295695,EBI-295687

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1156

1156

Nuclear pore complex protein Nup133

PRO_0000204838

Amino acid modifications

Modified residue

1

1

N-acetylmethionine Ref.12

Modified residue

7

1

Phosphoserine Ref.12

Modified residue

27

1

Phosphoserine Ref.10 Ref.12

Modified residue

28

1

Phosphothreonine Ref.10 Ref.12

Modified residue

41

1

Phosphoserine Ref.10

Modified residue

45

1

Phosphoserine Ref.7 Ref.10 Ref.11 Ref.12

Modified residue

50

1

Phosphoserine Ref.6 Ref.7 Ref.8 Ref.9 Ref.10 Ref.11 Ref.12

Modified residue

480

1

Phosphoserine Ref.11

Modified residue

501

1

Phosphoserine By similarity

Natural variations

Natural variant

106

1

T → P.
Corresponds to variant rs428231 [ dbSNP | Ensembl ].

VAR_030829

Natural variant

294

1

I → V.
Corresponds to variant rs11805194 [ dbSNP | Ensembl ].

VAR_030830

Natural variant

326

1

G → V in a breast cancer sample; somatic mutation. Ref.15

VAR_035854

Natural variant

406

1

Q → R.
Corresponds to variant rs1065674 [ dbSNP | Ensembl ].

VAR_030831

Natural variant

448

1

G → R in a breast cancer sample; somatic mutation. Ref.15

VAR_035855

Experimental info

Sequence conflict

61

1

R → G in BAA91829. Ref.1

Sequence conflict

146

1

P → S in BAA91829. Ref.1

Sequence conflict

345

1

L → F in AAH20107. Ref.3

Sequence conflict

626

1

S → N in BAA91829. Ref.1

Sequence conflict

928

1

F → L in BAA91885. Ref.1

Secondary structure

1

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1156

Helix Strand Turn

Details...

Beta strand

77 – 83

7

Helix

90 – 98

9

Beta strand

105 – 109

5

Beta strand

113 – 119

7

Beta strand

122 – 127

6

Helix

134 – 136

3

Beta strand

139 – 143

5

Helix

153 – 155

3

Beta strand

156 – 160

5

Beta strand

172 – 178

7

Beta strand

183 – 188

6

Beta strand

197 – 200

4

Beta strand

209 – 215

7

Turn

216 – 218

3

Beta strand

219 – 224

6

Beta strand

229 – 234

6

Beta strand

240 – 244

5

Beta strand

274 – 280

7

Turn

281 – 284

4

Beta strand

285 – 299

15

Beta strand

304 – 311

8

Helix

312 – 325

14

Helix

331 – 335

5

Beta strand

339 – 348

10

Beta strand

351 – 359

9

Beta strand

363 – 365

3

Beta strand

367 – 375

9

Beta strand

386 – 390

5

Helix

400 – 402

3

Beta strand

406 – 408

3

Beta strand

412 – 420

9

Beta strand

422 – 429

8

Beta strand

440 – 443

4

Helix

446 – 448

3

Beta strand

451 – 457

7

Beta strand

460 – 465

6

Turn

466 – 468

3

Beta strand

469 – 475

7

Helix

936 – 942

7

Helix

946 – 959

14

Helix

964 – 980

17

Helix

985 – 1006

22

Helix

1012 – 1015

4

Beta strand

1020 – 1023

4

Helix

1028 – 1034

7

Helix

1045 – 1051

7

Turn

1052 – 1057

6

Helix

1067 – 1079

13

Helix

1096 – 1102

7

Helix

1125 – 1128

4

Helix

1142 – 1155

14

Sequences

	Sequence		Length	Mass (Da)
	Q8WUM0 [UniParc]. Last modified April 3, 2007. Version 2. Checksum: 78B733E353824577	FASTA	1,156	128,979
	10 20 30 40 50 60 MFPAAPSPRT PGTGSRRGPL AGLGPGSTPR TASRKGLPLG SAVSSPVLFS PVGRRSSLSS 70 80 90 100 110 120 RGTPTRMFPH HSITESVNYD VKTFGSSLPV KVMEALTLAE VDDQLTINID EGGWACLVCK 130 140 150 160 170 180 EKLIIWKIAL SPITKLSVCK ELQLPPSDFH WSADLVALSY SSPSGEAHST QAVAVMVATR 190 200 210 220 230 240 EGSIRYWPSL AGEDTYTEAF VDSGGDKTYS FLTAVQGGSF ILSSSGSQLI RLIPESSGKI 250 260 270 280 290 300 HQHILPQGQG MLSGIGRKVS SLFGILSPSS DLTLSSVLWD RERSSFYSLT SSNISKWELD 310 320 330 340 350 360 DSSEKHAYSW DINRALKENI TDAIWGSESN YEAIKEGVNI RYLDLKQNCD GLVILAAAWH 370 380 390 400 410 420 SADNPCLIYY SLITIEDNGC QMSDAVTVEV TQYNPPFQSE DLILCQLTVP NFSNQTAYLY 430 440 450 460 470 480 NESAVYVCST GTGKFSLPQE KIVFNAQGDS VLGAGACGGV PIIFSRNSGL VSITSRENVS 490 500 510 520 530 540 ILAEDLEGSL ASSVAGPNSE SMIFETTTKN ETIAQEDKIK LLKAAFLQYC RKDLGHAQMV 550 560 570 580 590 600 VDELFSSHSD LDSDSELDRA VTQISVDLMD DYPASDPRWA ESVPEEAPGF SNTSLIILHQ 610 620 630 640 650 660 LEDKMKAHSF LMDFIHQVGL FGRLGSFPVR GTPMATRLLL CEHAEKLSAA IVLKNHHSRL 670 680 690 700 710 720 SDLVNTAILI ALNKREYEIP SNLTPADVFF REVSQVDTIC ECLLEHEEQV LRDAPMDSIE 730 740 750 760 770 780 WAEVVINVNN ILKDMLQAAS HYRQNRNSLY RREESLEKEP EYVPWTATSG PGGIRTVIIR 790 800 810 820 830 840 QHEIVLKVAY PQADSNLRNI VTEQLVALID CFLDGYVSQL KSVDKSSNRE RYDNLEMEYL 850 860 870 880 890 900 QKRSDLLSPL LSLGQYLWAA SLAEKYCDFD ILVQMCEQTD NQSRLQRYMT QFADQNFSDF 910 920 930 940 950 960 LFRWYLEKGK RGKLLSQPIS QHGQLANFLQ AHEHLSWLHE INSQELEKAH ATLLGLANME 970 980 990 1000 1010 1020 TRYFAKKKTL LGLSKLAALA SDFSEDMLQE KIEEMAEQER FLLHQETLPE QLLAEKQLNL 1030 1040 1050 1060 1070 1080 SAMPVLTAPQ LIGLYICEEN RRANEYDFKK ALDLLEYIDE EEDININDLK LEILCKALQR 1090 1100 1110 1120 1130 1140 DNWSSSDGKD DPIEVSKDSI FVKILQKLLK DGIQLSEYLP EVKDLLQADQ LGSLKSNPYF 1150 EFVLKANYEY YVQGQI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[2]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skin.
[4]	"An evolutionarily conserved NPC subcomplex, which redistributes in part to kinetochores in mammalian cells." Belgareh N., Rabut G., Bai S.W., van Overbeek M., Beaudouin J., Daigle N., Zatsepina O.V., Pasteau F., Labas V., Fromont-Racine M., Ellenberg J., Doye V. J. Cell Biol. 154:1147-1160(2001) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION, SUBUNIT, SUBCELLULAR LOCATION.
[5]	"Novel vertebrate nucleoporins Nup133 and Nup160 play a role in mRNA export." Vasu S., Shah S., Orjalo A., Park M., Fischer W.H., Forbes D.J. J. Cell Biol. 155:339-354(2001) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION, FUNCTION, SUBUNIT, SUBCELLULAR LOCATION.
[6]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-50, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[7]	"A probability-based approach for high-throughput protein phosphorylation analysis and site localization." Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P. Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-45 AND SER-50, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[8]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-50, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-50, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[10]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-27; THR-28; SER-41; SER-45 AND SER-50, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[11]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-45; SER-50 AND SER-480, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[12]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-7; SER-27; THR-28; SER-45 AND SER-50, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[13]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[14]	"Structural and functional analysis of Nup133 domains reveals modular building blocks of the nuclear pore complex." Berke I.C., Boehmer T., Blobel G., Schwartz T.U. J. Cell Biol. 167:591-597(2004) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS) OF 67-514.
[15]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] VAL-326 AND ARG-448.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AK001676 mRNA. Translation: BAA91829.1.
AK001754 mRNA. Translation: BAA91885.1. Different initiation.
AK022572 mRNA. Translation: BAB14106.1. Different initiation.
AK314431 mRNA. Translation: BAG37045.1.
AL121990, AL139252, AL160004 Genomic DNA. Translation: CAI22011.1.
AL139252, AL121990, AL160004 Genomic DNA. Translation: CAI22354.1.
AL160004, AL121990, AL139252 Genomic DNA. Translation: CAI19048.1.
BC020107 mRNA. Translation: AAH20107.1.

IPI

IPI00291200.

RefSeq

NP_060700.2. NM_018230.2.

UniGene

Hs.12457.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1XKS	X-ray	2.35	A	67-514	[»]
3CQC	X-ray	2.53	B	935-1156	[»]
3CQG	X-ray	3.00	B	934-1156	[»]
3I4R	X-ray	3.53	B	517-1156	[»]

DisProt

DP00318.

ProteinModelPortal

Q8WUM0.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q8WUM0. 8 interactions.

MINT

MINT-3046670.

STRING

9606.ENSP00000261396.

PTM databases

PhosphoSite

Q8WUM0.

Polymorphism databases

DMDM

143811430.

Proteomic databases

PaxDb

Q8WUM0.

PRIDE

Q8WUM0.

Protocols and materials databases

DNASU

55746.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000261396; ENSP00000261396; ENSG00000069248.

GeneID

55746.

KEGG

hsa:55746.

UCSC

uc001htn.3. human.

Organism-specific databases

CTD

55746.

GeneCards

GC01M229580.

H-InvDB

HIX0001680.

HGNC

HGNC:18016. NUP133.

MIM

607613. gene.

neXtProt

NX_Q8WUM0.

PharmGKB

PA31847.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG312399.

HOGENOM

HOG000293246.

HOVERGEN

HBG052678.

InParanoid

Q8WUM0.

KO

K14300.

OMA

YLEKGKR.

OrthoDB

EOG469QT0.

PhylomeDB

Q8WUM0.

Enzyme and pathway databases

Reactome

REACT_111217. Metabolism.
REACT_115566. Cell Cycle.
REACT_116125. Disease.
REACT_15518. Transmembrane transport of small molecules.
REACT_21300. Mitotic M-M/G1 phases.
REACT_6900. Immune System.

Gene expression databases

ArrayExpress

Q8WUM0.

Bgee

Q8WUM0.

CleanEx

HS_NUP133.

Genevestigator

Q8WUM0.

GermOnline

ENSG00000069248. Homo sapiens.

Family and domain databases

Gene3D

2.130.10.10. 1 hit.

InterPro

IPR007187. Nucleoporin_Nup133/Nup155_C.
IPR014908. Nucleoporin_Nup133/Nup155_N.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]

Pfam

PF03177. Nucleoporin_C. 1 hit.
PF08801. Nucleoporin_N. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

NUP133. human.

EvolutionaryTrace

Q8WUM0.

GenomeRNAi

55746.

NextBio

60719.

SOURCE

Search...

Entry information

Entry name

NU133_HUMAN

Accession

Primary (citable) accession number: Q8WUM0
Secondary accession number(s): B2RAZ8 , Q5T8N0, Q9H9W2, Q9NV71, Q9NVC4

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 28, 2003
Last sequence update:	April 3, 2007
Last modified:	May 1, 2013
This is version 112 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.