Q8WUK0 (PTPM1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein-tyrosine phosphatase mitochondrial 1
EC=3.1.3.16
EC=3.1.3.48

Alternative name(s):
PTEN-like phosphatase
Phosphoinositide lipid phosphatase

Gene names

Name:	PTPMT1
Synonyms:	MOSP, PLIP
ORF Names:	PNAS-129

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	201 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Protein phosphatase that specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production. Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues. Probably involved in regulation of insulin secretion in pancreatic beta cells By similarity.
Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. A phosphoprotein + H2O = a protein + phosphate.
Subcellular location	Mitochondrion inner membrane By similarity. Note: Associated with the inner membrane By similarity.
Sequence similarities	Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. Contains 1 tyrosine-protein phosphatase domain.
Caution	Was originally erroneously termed DUSP23.
Sequence caution	The sequence AAH14048.1 differs from that shown. Reason: Erroneous initiation. The sequence AAK07545.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Coding sequence diversity	Alternative splicing
Domain	Transit peptide
Molecular function	Hydrolase Protein phosphatase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	inositol phosphate dephosphorylation Inferred from Biological aspect of Ancestor. Source: RefGenome
Cellular component	mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity Inferred from Biological aspect of Ancestor. Source: RefGenome protein tyrosine phosphatase activity Inferred from electronic annotation. Source: EC protein tyrosine/serine/threonine phosphatase activity Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8WUK0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8WUK0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     85-148: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 27	27	Mitochondrion Potential
	Chain	28 – 201	174	Protein-tyrosine phosphatase mitochondrial 1		PRO_0000025423
Regions
	Domain	109 – 183	75	Tyrosine-protein phosphatase
Sites
	Active site	132	1	Phosphocysteine intermediate By similarity
Natural variations
	Alternative sequence	85 – 148	64	Missing in isoform 2.		VSP_015009

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 88A4CC76EEFD0835	FASTA	201	22,844
	10 20 30 40 50 60 MAATALLEAG LARVLFYPTL LYTLFRGKVP GRAHRDWYHR IDPTVLLGAL PLRSLTRQLV 70 80 90 100 110 120 QDENVRGVIT MNEEYETRFL CNSSQEWKRL GVEQLRLSTV DMTGIPTLDN LQKGVQFALK 130 140 150 160 170 180 YQSLGQCVYV HCKAGRSRSA TMVAAYLIQV HKWSPEEAVR AIAKIRSYIH IRPGQLDVLK 190 200 EFHKQITARA TKDGTFVISK T
	Isoform 2 [UniParc]. Checksum: E1B3966F55F1065D	FASTA	137	15,689
	10 20 30 40 50 60 MAATALLEAG LARVLFYPTL LYTLFRGKVP GRAHRDWYHR IDPTVLLGAL PLRSLTRQLV 70 80 90 100 110 120 QDENVRGVIT MNEEYETRFL CNSSQVHKWS PEEAVRAIAK IRSYIHIRPG QLDVLKEFHK 130 QITARATKDG TFVISKT

References

[1]	Lin L., Ke R., Li H., Zhou G., Shen C., Yu R., Zhong G., Xiao W., Li M., Yang S. Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Cervix and Kidney.
[3]	"Human acute promyelocytic leukemia cell line NB4's apoptosis/differentiation related genes." Yu W.-Q., Sun B.-Z., Chai Y.-B., Zhu F., Liu X.-S., Li Z., Lu F., Yan W., Yang H., Zhao Z.-L. Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 68-201 (ISOFORM 2). Tissue: Promyelocytic leukemia.
[4]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY333987 mRNA. Translation: AAP94732.1. BC014048 mRNA. Translation: AAH14048.1. Different initiation. BC020242 mRNA. Translation: AAH20242.1. AF277187 mRNA. Translation: AAK07545.1. Different initiation.
IPI	IPI00174190. IPI00647467.
RefSeq	NP_001137456.1. NM_001143984.1. NP_783859.1. NM_175732.2.
UniGene	Hs.656205. Hs.728160.
3D structure databases
ProteinModelPortal	Q8WUK0.
SMR	Q8WUK0. Positions 37-193.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8WUK0.
PTM databases
PhosphoSite	Q8WUK0.
Polymorphism databases
DMDM	73621420.
Proteomic databases
PRIDE	Q8WUK0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000326674; ENSP00000325958; ENSG00000110536.
GeneID	114971.
KEGG	hsa:114971.
UCSC	uc001nfs.2. human.
Organism-specific databases
CTD	114971.
GeneCards	GC11P047586.
HGNC	HGNC:26965. PTPMT1.
MIM	609538. gene.
neXtProt	NX_Q8WUK0.
PharmGKB	PA142671115.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00390000014065.
HOGENOM	HBG314297.
HOVERGEN	HBG079822.
InParanoid	Q8WUK0.
OMA	TTDIFES.
OrthoDB	EOG4WWRKR.
PhylomeDB	Q8WUK0.
Enzyme and pathway databases
BioCyc	MetaCyc:MONOMER-15190.
Gene expression databases
ArrayExpress	Q8WUK0.
Bgee	Q8WUK0.
CleanEx	HS_PTPMT1.
Genevestigator	Q8WUK0.
GermOnline	ENSG00000110536. Homo sapiens.
Family and domain databases
InterPro	IPR000340. Dual-sp_phosphatase_cat-dom. IPR000387. Tyr/Dual-specificity_Pase. IPR016130. Tyr_Pase_AS. [Graphical view]
KO	K14165.
Pfam	PF00782. DSPc. 1 hit. [Graphical view]
PROSITE	PS00383. TYR_PHOSPHATASE_1. 1 hit. PS50056. TYR_PHOSPHATASE_2. 1 hit. PS50054. TYR_PHOSPHATASE_DUAL. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	79464.
SOURCE	Search...

Entry information

Entry name

PTPM1_HUMAN

Accession

Primary (citable) accession number: Q8WUK0
Secondary accession number(s): Q7Z557, Q96CR2, Q9BXV8

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2005
Last sequence update:	March 1, 2002
Last modified:	January 25, 2012
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.