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Q8WUK0

- PTPM1_HUMAN

UniProt

Q8WUK0 - PTPM1_HUMAN

Protein

Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1

Gene

PTPMT1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle. Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production. Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues. Probably involved in regulation of insulin secretion in pancreatic beta cells By similarity.By similarity

    Catalytic activityi

    Phosphatidylglycerophosphate + H2O = phosphatidylglycerol + phosphate.
    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei132 – 1321Phosphocysteine intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. phosphatidylglycerophosphatase activity Source: UniProtKB
    2. phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity Source: RefGenome
    3. protein tyrosine/serine/threonine phosphatase activity Source: RefGenome
    4. protein tyrosine phosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cardiolipin biosynthetic process Source: UniProtKB
    2. glycerophospholipid biosynthetic process Source: Reactome
    3. inositol phosphate dephosphorylation Source: RefGenome
    4. phosphatidylglycerol biosynthetic process Source: Reactome
    5. phospholipid metabolic process Source: Reactome
    6. protein dephosphorylation Source: RefGenome
    7. small molecule metabolic process Source: Reactome

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

    Enzyme and pathway databases

    BioCyciMetaCyc:HS03319-MONOMER.
    ReactomeiREACT_121280. Synthesis of PG.
    UniPathwayiUPA00084; UER00504.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 (EC:3.1.3.27)
    Alternative name(s):
    PTEN-like phosphatase
    Phosphoinositide lipid phosphatase
    Protein-tyrosine phosphatase mitochondrial 1 (EC:3.1.3.16, EC:3.1.3.48)
    Gene namesi
    Name:PTPMT1
    Synonyms:MOSP, PLIP
    ORF Names:PNAS-129
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:26965. PTPMT1.

    Subcellular locationi

    Mitochondrion inner membrane By similarity
    Note: Associated with the inner membrane.By similarity

    GO - Cellular componenti

    1. mitochondrial inner membrane Source: UniProtKB-SubCell
    2. mitochondrion Source: RefGenome
    3. nucleus Source: UniProt

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142671115.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2727MitochondrionSequence AnalysisAdd
    BLAST
    Chaini28 – 201174Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1PRO_0000025423Add
    BLAST

    Proteomic databases

    MaxQBiQ8WUK0.
    PaxDbiQ8WUK0.
    PRIDEiQ8WUK0.

    PTM databases

    PhosphoSiteiQ8WUK0.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8WUK0.
    BgeeiQ8WUK0.
    CleanExiHS_PTPMT1.
    GenevestigatoriQ8WUK0.

    Organism-specific databases

    HPAiHPA043932.

    Interactioni

    Protein-protein interaction databases

    BioGridi125402. 5 interactions.
    IntActiQ8WUK0. 3 interactions.
    MINTiMINT-8247525.
    STRINGi9606.ENSP00000325958.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8WUK0.
    SMRiQ8WUK0. Positions 37-193.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini109 – 18375Tyrosine-protein phosphataseAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiNOG146651.
    HOGENOMiHOG000220855.
    HOVERGENiHBG079822.
    InParanoidiQ8WUK0.
    KOiK14165.
    OMAiISIYICP.
    OrthoDBiEOG7KDFCN.
    PhylomeDBiQ8WUK0.
    TreeFamiTF319745.

    Family and domain databases

    Gene3Di3.90.190.10. 1 hit.
    InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
    IPR024950. DUSP.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view]
    PANTHERiPTHR10159. PTHR10159. 1 hit.
    PfamiPF00782. DSPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8WUK0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAATALLEAG LARVLFYPTL LYTLFRGKVP GRAHRDWYHR IDPTVLLGAL    50
    PLRSLTRQLV QDENVRGVIT MNEEYETRFL CNSSQEWKRL GVEQLRLSTV 100
    DMTGIPTLDN LQKGVQFALK YQSLGQCVYV HCKAGRSRSA TMVAAYLIQV 150
    HKWSPEEAVR AIAKIRSYIH IRPGQLDVLK EFHKQITARA TKDGTFVISK 200
    T 201
    Length:201
    Mass (Da):22,844
    Last modified:March 1, 2002 - v1
    Checksum:i88A4CC76EEFD0835
    GO
    Isoform 2 (identifier: Q8WUK0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         85-148: Missing.

    Show »
    Length:137
    Mass (Da):15,689
    Checksum:iE1B3966F55F1065D
    GO
    Isoform 3 (identifier: Q8WUK0-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         59-151: LVQDENVRGV...MVAAYLIQVH → VSRAGEPGPL...PHQAWPAGCS
         152-201: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:151
    Mass (Da):16,459
    Checksum:i59DFA3B7642E84F0
    GO

    Sequence cautioni

    The sequence AAH14048.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAK07545.1 differs from that shown. Reason: Erroneous initiation.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei59 – 15193LVQDE…LIQVH → VSRAGEPGPLPRPRRSVPVG PLGSPPSLLSHLFASAAGTG RERARGDHHERGVRDEVPVQ LFTGAQMESRGGCKSHRQDP VIHPHQAWPAGCS in isoform 3. 1 PublicationVSP_045030Add
    BLAST
    Alternative sequencei85 – 14864Missing in isoform 2. 2 PublicationsVSP_015009Add
    BLAST
    Alternative sequencei152 – 20150Missing in isoform 3. 1 PublicationVSP_045031Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY333987 mRNA. Translation: AAP94732.1.
    AC090559 Genomic DNA. No translation available.
    AC104942 Genomic DNA. No translation available.
    BC014048 mRNA. Translation: AAH14048.1. Different initiation.
    BC020242 mRNA. Translation: AAH20242.1.
    BC073798 mRNA. No translation available.
    AF277187 mRNA. Translation: AAK07545.1. Different initiation.
    CCDSiCCDS41643.1. [Q8WUK0-1]
    CCDS44593.1. [Q8WUK0-3]
    RefSeqiNP_001137456.1. NM_001143984.1. [Q8WUK0-3]
    NP_783859.1. NM_175732.2. [Q8WUK0-1]
    UniGeneiHs.656205.
    Hs.742231.

    Genome annotation databases

    EnsembliENST00000326656; ENSP00000325882; ENSG00000110536. [Q8WUK0-2]
    ENST00000326674; ENSP00000325958; ENSG00000110536. [Q8WUK0-1]
    ENST00000426530; ENSP00000410272; ENSG00000110536. [Q8WUK0-3]
    GeneIDi114971.
    KEGGihsa:114971.
    UCSCiuc001nfs.4. human. [Q8WUK0-1]
    uc009ylt.3. human. [Q8WUK0-2]

    Polymorphism databases

    DMDMi73621420.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY333987 mRNA. Translation: AAP94732.1 .
    AC090559 Genomic DNA. No translation available.
    AC104942 Genomic DNA. No translation available.
    BC014048 mRNA. Translation: AAH14048.1 . Different initiation.
    BC020242 mRNA. Translation: AAH20242.1 .
    BC073798 mRNA. No translation available.
    AF277187 mRNA. Translation: AAK07545.1 . Different initiation.
    CCDSi CCDS41643.1. [Q8WUK0-1 ]
    CCDS44593.1. [Q8WUK0-3 ]
    RefSeqi NP_001137456.1. NM_001143984.1. [Q8WUK0-3 ]
    NP_783859.1. NM_175732.2. [Q8WUK0-1 ]
    UniGenei Hs.656205.
    Hs.742231.

    3D structure databases

    ProteinModelPortali Q8WUK0.
    SMRi Q8WUK0. Positions 37-193.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125402. 5 interactions.
    IntActi Q8WUK0. 3 interactions.
    MINTi MINT-8247525.
    STRINGi 9606.ENSP00000325958.

    Chemistry

    ChEMBLi CHEMBL2052033.

    PTM databases

    PhosphoSitei Q8WUK0.

    Polymorphism databases

    DMDMi 73621420.

    Proteomic databases

    MaxQBi Q8WUK0.
    PaxDbi Q8WUK0.
    PRIDEi Q8WUK0.

    Protocols and materials databases

    DNASUi 114971.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000326656 ; ENSP00000325882 ; ENSG00000110536 . [Q8WUK0-2 ]
    ENST00000326674 ; ENSP00000325958 ; ENSG00000110536 . [Q8WUK0-1 ]
    ENST00000426530 ; ENSP00000410272 ; ENSG00000110536 . [Q8WUK0-3 ]
    GeneIDi 114971.
    KEGGi hsa:114971.
    UCSCi uc001nfs.4. human. [Q8WUK0-1 ]
    uc009ylt.3. human. [Q8WUK0-2 ]

    Organism-specific databases

    CTDi 114971.
    GeneCardsi GC11P047586.
    HGNCi HGNC:26965. PTPMT1.
    HPAi HPA043932.
    MIMi 609538. gene.
    neXtProti NX_Q8WUK0.
    PharmGKBi PA142671115.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG146651.
    HOGENOMi HOG000220855.
    HOVERGENi HBG079822.
    InParanoidi Q8WUK0.
    KOi K14165.
    OMAi ISIYICP.
    OrthoDBi EOG7KDFCN.
    PhylomeDBi Q8WUK0.
    TreeFami TF319745.

    Enzyme and pathway databases

    UniPathwayi UPA00084 ; UER00504 .
    BioCyci MetaCyc:HS03319-MONOMER.
    Reactomei REACT_121280. Synthesis of PG.

    Miscellaneous databases

    ChiTaRSi PTPMT1. human.
    GenomeRNAii 114971.
    NextBioi 79464.
    PROi Q8WUK0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8WUK0.
    Bgeei Q8WUK0.
    CleanExi HS_PTPMT1.
    Genevestigatori Q8WUK0.

    Family and domain databases

    Gene3Di 3.90.190.10. 1 hit.
    InterProi IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR024950. DUSP.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view ]
    PANTHERi PTHR10159. PTHR10159. 1 hit.
    Pfami PF00782. DSPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Lin L., Ke R., Li H., Zhou G., Shen C., Yu R., Zhong G., Xiao W., Li M., Yang S.
      Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
      Tissue: Cervix, Kidney and Kidney adenocarcinoma.
    4. "Human acute promyelocytic leukemia cell line NB4's apoptosis/differentiation related genes."
      Yu W.-Q., Sun B.-Z., Chai Y.-B., Zhu F., Liu X.-S., Li Z., Lu F., Yan W., Yang H., Zhao Z.-L.
      Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 68-201 (ISOFORM 2).
      Tissue: Promyelocytic leukemia.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiPTPM1_HUMAN
    AccessioniPrimary (citable) accession number: Q8WUK0
    Secondary accession number(s): E9PAT8
    , Q7Z557, Q96CR2, Q9BXV8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2005
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 117 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3