Q8WUK0 (PTPM1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1
EC=3.1.3.27

Alternative name(s):
PTEN-like phosphatase
Phosphoinositide lipid phosphatase
Protein-tyrosine phosphatase mitochondrial 1
EC=3.1.3.16
EC=3.1.3.48

Gene names

Name:	PTPMT1
Synonyms:	MOSP, PLIP
ORF Names:	PNAS-129

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	201 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle. Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production. Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues. Probably involved in regulation of insulin secretion in pancreatic beta cells By similarity.
Catalytic activity	Phosphatidylglycerophosphate + H2O = phosphatidylglycerol + phosphate. Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. A phosphoprotein + H2O = a protein + phosphate.
Pathway	Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 2/2.
Subcellular location	Mitochondrion inner membrane By similarity. Note: Associated with the inner membrane By similarity.
Sequence similarities	Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. Contains 1 tyrosine-protein phosphatase domain.
Caution	Was originally erroneously termed DUSP23.
Sequence caution	The sequence AAH14048.1 differs from that shown. Reason: Erroneous initiation. The sequence AAK07545.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Lipid biosynthesis Lipid metabolism Phospholipid biosynthesis Phospholipid metabolism
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Coding sequence diversity	Alternative splicing
Domain	Transit peptide
Molecular function	Hydrolase Protein phosphatase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cardiolipin biosynthetic process Inferred from sequence or structural similarity. Source: UniProtKB inositol phosphate dephosphorylation Inferred from Biological aspect of Ancestor. Source: RefGenome peptidyl-tyrosine dephosphorylation Inferred from electronic annotation. Source: GOC
Cellular_component	mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrion Inferred from Biological aspect of Ancestor. Source: RefGenome
Molecular_function	phosphatidylglycerophosphatase activity Inferred from sequence or structural similarity. Source: UniProtKB phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity Inferred from Biological aspect of Ancestor. Source: RefGenome protein tyrosine phosphatase activity Inferred from electronic annotation. Source: EC protein tyrosine/serine/threonine phosphatase activity Inferred from Biological aspect of Ancestor. Source: RefGenome
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8WUK0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8WUK0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     85-148: Missing.

Isoform 3 (identifier: Q8WUK0-3)

The sequence of this isoform differs from the canonical sequence as follows:
     59-151: LVQDENVRGV...MVAAYLIQVH → VSRAGEPGPL...PHQAWPAGCS
     152-201: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 27	27	Mitochondrion Potential
	Chain	28 – 201	174	Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1		PRO_0000025423
Regions
	Domain	109 – 183	75	Tyrosine-protein phosphatase
Sites
	Active site	132	1	Phosphocysteine intermediate By similarity
Natural variations
	Alternative sequence	59 – 151	93	LVQDE…LIQVH → VSRAGEPGPLPRPRRSVPVG PLGSPPSLLSHLFASAAGTG RERARGDHHERGVRDEVPVQ LFTGAQMESRGGCKSHRQDP VIHPHQAWPAGCS in isoform 3.		VSP_045030
	Alternative sequence	85 – 148	64	Missing in isoform 2.		VSP_015009
	Alternative sequence	152 – 201	50	Missing in isoform 3.		VSP_045031

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 88A4CC76EEFD0835	FASTA	201	22,844
	10 20 30 40 50 60 MAATALLEAG LARVLFYPTL LYTLFRGKVP GRAHRDWYHR IDPTVLLGAL PLRSLTRQLV 70 80 90 100 110 120 QDENVRGVIT MNEEYETRFL CNSSQEWKRL GVEQLRLSTV DMTGIPTLDN LQKGVQFALK 130 140 150 160 170 180 YQSLGQCVYV HCKAGRSRSA TMVAAYLIQV HKWSPEEAVR AIAKIRSYIH IRPGQLDVLK 190 200 EFHKQITARA TKDGTFVISK T
	Isoform 2 [UniParc]. Checksum: E1B3966F55F1065D	FASTA	137	15,689
	10 20 30 40 50 60 MAATALLEAG LARVLFYPTL LYTLFRGKVP GRAHRDWYHR IDPTVLLGAL PLRSLTRQLV 70 80 90 100 110 120 QDENVRGVIT MNEEYETRFL CNSSQVHKWS PEEAVRAIAK IRSYIHIRPG QLDVLKEFHK 130 QITARATKDG TFVISKT
	Isoform 3 [UniParc]. Checksum: 59DFA3B7642E84F0	FASTA	151	16,459
	10 20 30 40 50 60 MAATALLEAG LARVLFYPTL LYTLFRGKVP GRAHRDWYHR IDPTVLLGAL PLRSLTRQVS 70 80 90 100 110 120 RAGEPGPLPR PRRSVPVGPL GSPPSLLSHL FASAAGTGRE RARGDHHERG VRDEVPVQLF 130 140 150 TGAQMESRGG CKSHRQDPVI HPHQAWPAGC S

References

[1]	Lin L., Ke R., Li H., Zhou G., Shen C., Yu R., Zhong G., Xiao W., Li M., Yang S. Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[2]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3). Tissue: Cervix, Kidney and Kidney adenocarcinoma.
[4]	"Human acute promyelocytic leukemia cell line NB4's apoptosis/differentiation related genes." Yu W.-Q., Sun B.-Z., Chai Y.-B., Zhu F., Liu X.-S., Li Z., Lu F., Yan W., Yang H., Zhao Z.-L. Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 68-201 (ISOFORM 2). Tissue: Promyelocytic leukemia.
[5]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY333987 mRNA. Translation: AAP94732.1. AC090559 Genomic DNA. No translation available. AC104942 Genomic DNA. No translation available. BC014048 mRNA. Translation: AAH14048.1. Different initiation. BC020242 mRNA. Translation: AAH20242.1. BC073798 mRNA. No translation available. AF277187 mRNA. Translation: AAK07545.1. Different initiation.
IPI	IPI00174190. IPI00647467. IPI00921066.
RefSeq	NP_001137456.1. NM_001143984.1. NP_783859.1. NM_175732.2.
UniGene	Hs.656205. Hs.742231.
3D structure databases
ProteinModelPortal	Q8WUK0.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000325958.
PTM databases
PhosphoSite	Q8WUK0.
Polymorphism databases
DMDM	73621420.
Proteomic databases
PaxDb	Q8WUK0.
PRIDE	Q8WUK0.
Protocols and materials databases
DNASU	114971.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000326656; ENSP00000325882; ENSG00000110536. ENST00000326674; ENSP00000325958; ENSG00000110536. ENST00000426530; ENSP00000410272; ENSG00000110536.
GeneID	114971.
KEGG	hsa:114971.
UCSC	uc001nfs.4. human. uc009ylt.3. human.
Organism-specific databases
CTD	114971.
GeneCards	GC11P047586.
HGNC	HGNC:26965. PTPMT1.
HPA	HPA043932.
MIM	609538. gene.
neXtProt	NX_Q8WUK0.
PharmGKB	PA142671115.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG146651.
HOGENOM	HOG000220855.
HOVERGEN	HBG079822.
InParanoid	Q8WUK0.
KO	K14165.
OMA	TDIFESP.
OrthoDB	EOG4WWRKR.
Enzyme and pathway databases
BioCyc	MetaCyc:HS03319-MONOMER.
UniPathway	UPA00084; UER00504.
Gene expression databases
ArrayExpress	Q8WUK0.
Bgee	Q8WUK0.
CleanEx	HS_PTPMT1.
Genevestigator	Q8WUK0.
GermOnline	ENSG00000110536. Homo sapiens.
Family and domain databases
InterPro	IPR000340. Dual-sp_phosphatase_cat-dom. IPR024950. DUSP. IPR000387. Tyr/Dual-sp_Pase. IPR016130. Tyr_Pase_AS. [Graphical view]
PANTHER	PTHR10159. PTHR10159. 1 hit.
Pfam	PF00782. DSPc. 1 hit. [Graphical view]
PROSITE	PS00383. TYR_PHOSPHATASE_1. 1 hit. PS50056. TYR_PHOSPHATASE_2. 1 hit. PS50054. TYR_PHOSPHATASE_DUAL. False negative. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	PTPMT1. human.
GenomeRNAi	114971.
NextBio	79464.
SOURCE	Search...

Entry information

Entry name

PTPM1_HUMAN

Accession

Primary (citable) accession number: Q8WUK0
Secondary accession number(s): E9PAT8 , Q7Z557, Q96CR2, Q9BXV8

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2005
Last sequence update:	March 1, 2002
Last modified:	May 1, 2013
This is version 102 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.