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Protein

Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1

Gene

PTPMT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle. Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production. Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues. Probably involved in regulation of insulin secretion in pancreatic beta cells (By similarity).By similarity

Catalytic activityi

Phosphatidylglycerophosphate + H2O = phosphatidylglycerol + phosphate.
Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei132 – 1321Phosphocysteine intermediatePROSITE-ProRule annotation

GO - Molecular functioni

  1. phosphatidylglycerophosphatase activity Source: UniProtKB
  2. phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity Source: GO_Central
  3. protein tyrosine/serine/threonine phosphatase activity Source: GO_Central
  4. protein tyrosine phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. cardiolipin biosynthetic process Source: UniProtKB
  2. glycerophospholipid biosynthetic process Source: Reactome
  3. inositol phosphate dephosphorylation Source: GO_Central
  4. phosphatidylglycerol biosynthetic process Source: Reactome
  5. phospholipid metabolic process Source: Reactome
  6. protein dephosphorylation Source: GO_Central
  7. small molecule metabolic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

BioCyciMetaCyc:HS03319-MONOMER.
ReactomeiREACT_121280. Synthesis of PG.
UniPathwayiUPA00084; UER00504.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 (EC:3.1.3.27)
Alternative name(s):
PTEN-like phosphatase
Phosphoinositide lipid phosphatase
Protein-tyrosine phosphatase mitochondrial 1 (EC:3.1.3.16, EC:3.1.3.48)
Gene namesi
Name:PTPMT1
Synonyms:MOSP, PLIP
ORF Names:PNAS-129
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:26965. PTPMT1.

Subcellular locationi

Mitochondrion inner membrane By similarity
Note: Associated with the inner membrane.By similarity

GO - Cellular componenti

  1. integral component of mitochondrial inner membrane Source: Ensembl
  2. mitochondrion Source: GO_Central
  3. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671115.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2727MitochondrionSequence AnalysisAdd
BLAST
Chaini28 – 201174Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1PRO_0000025423Add
BLAST

Proteomic databases

MaxQBiQ8WUK0.
PaxDbiQ8WUK0.
PRIDEiQ8WUK0.

PTM databases

DEPODiQ8WUK0.
PhosphoSiteiQ8WUK0.

Expressioni

Gene expression databases

BgeeiQ8WUK0.
CleanExiHS_PTPMT1.
ExpressionAtlasiQ8WUK0. baseline and differential.
GenevestigatoriQ8WUK0.

Organism-specific databases

HPAiHPA043932.

Interactioni

Protein-protein interaction databases

BioGridi125402. 22 interactions.
IntActiQ8WUK0. 3 interactions.
MINTiMINT-8247525.
STRINGi9606.ENSP00000325958.

Structurei

3D structure databases

ProteinModelPortaliQ8WUK0.
SMRiQ8WUK0. Positions 37-193.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini109 – 18375Tyrosine-protein phosphataseAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiNOG146651.
GeneTreeiENSGT00390000014065.
HOGENOMiHOG000220855.
HOVERGENiHBG079822.
InParanoidiQ8WUK0.
KOiK14165.
OMAiNASCGRM.
OrthoDBiEOG7KDFCN.
PhylomeDBiQ8WUK0.
TreeFamiTF319745.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8WUK0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAATALLEAG LARVLFYPTL LYTLFRGKVP GRAHRDWYHR IDPTVLLGAL
60 70 80 90 100
PLRSLTRQLV QDENVRGVIT MNEEYETRFL CNSSQEWKRL GVEQLRLSTV
110 120 130 140 150
DMTGIPTLDN LQKGVQFALK YQSLGQCVYV HCKAGRSRSA TMVAAYLIQV
160 170 180 190 200
HKWSPEEAVR AIAKIRSYIH IRPGQLDVLK EFHKQITARA TKDGTFVISK

T
Length:201
Mass (Da):22,844
Last modified:March 1, 2002 - v1
Checksum:i88A4CC76EEFD0835
GO
Isoform 2 (identifier: Q8WUK0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     85-148: Missing.

Show »
Length:137
Mass (Da):15,689
Checksum:iE1B3966F55F1065D
GO
Isoform 3 (identifier: Q8WUK0-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     59-151: LVQDENVRGV...MVAAYLIQVH → VSRAGEPGPL...PHQAWPAGCS
     152-201: Missing.

Note: No experimental confirmation available.

Show »
Length:151
Mass (Da):16,459
Checksum:i59DFA3B7642E84F0
GO

Sequence cautioni

The sequence AAH14048.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAK07545.1 differs from that shown. Reason: Erroneous initiation. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei59 – 15193LVQDE…LIQVH → VSRAGEPGPLPRPRRSVPVG PLGSPPSLLSHLFASAAGTG RERARGDHHERGVRDEVPVQ LFTGAQMESRGGCKSHRQDP VIHPHQAWPAGCS in isoform 3. 1 PublicationVSP_045030Add
BLAST
Alternative sequencei85 – 14864Missing in isoform 2. 2 PublicationsVSP_015009Add
BLAST
Alternative sequencei152 – 20150Missing in isoform 3. 1 PublicationVSP_045031Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY333987 mRNA. Translation: AAP94732.1.
AC090559 Genomic DNA. No translation available.
AC104942 Genomic DNA. No translation available.
BC014048 mRNA. Translation: AAH14048.1. Different initiation.
BC020242 mRNA. Translation: AAH20242.1.
BC073798 mRNA. No translation available.
AF277187 mRNA. Translation: AAK07545.1. Different initiation.
CCDSiCCDS41643.1. [Q8WUK0-1]
CCDS44593.1. [Q8WUK0-3]
RefSeqiNP_001137456.1. NM_001143984.1. [Q8WUK0-3]
NP_783859.1. NM_175732.2. [Q8WUK0-1]
UniGeneiHs.656205.
Hs.742231.

Genome annotation databases

EnsembliENST00000326656; ENSP00000325882; ENSG00000110536. [Q8WUK0-2]
ENST00000326674; ENSP00000325958; ENSG00000110536. [Q8WUK0-1]
ENST00000426530; ENSP00000410272; ENSG00000110536. [Q8WUK0-3]
GeneIDi114971.
KEGGihsa:114971.
UCSCiuc001nfs.4. human. [Q8WUK0-1]
uc009ylt.3. human. [Q8WUK0-2]

Polymorphism databases

DMDMi73621420.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY333987 mRNA. Translation: AAP94732.1.
AC090559 Genomic DNA. No translation available.
AC104942 Genomic DNA. No translation available.
BC014048 mRNA. Translation: AAH14048.1. Different initiation.
BC020242 mRNA. Translation: AAH20242.1.
BC073798 mRNA. No translation available.
AF277187 mRNA. Translation: AAK07545.1. Different initiation.
CCDSiCCDS41643.1. [Q8WUK0-1]
CCDS44593.1. [Q8WUK0-3]
RefSeqiNP_001137456.1. NM_001143984.1. [Q8WUK0-3]
NP_783859.1. NM_175732.2. [Q8WUK0-1]
UniGeneiHs.656205.
Hs.742231.

3D structure databases

ProteinModelPortaliQ8WUK0.
SMRiQ8WUK0. Positions 37-193.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125402. 22 interactions.
IntActiQ8WUK0. 3 interactions.
MINTiMINT-8247525.
STRINGi9606.ENSP00000325958.

Chemistry

BindingDBiQ8WUK0.
ChEMBLiCHEMBL2052033.

PTM databases

DEPODiQ8WUK0.
PhosphoSiteiQ8WUK0.

Polymorphism databases

DMDMi73621420.

Proteomic databases

MaxQBiQ8WUK0.
PaxDbiQ8WUK0.
PRIDEiQ8WUK0.

Protocols and materials databases

DNASUi114971.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000326656; ENSP00000325882; ENSG00000110536. [Q8WUK0-2]
ENST00000326674; ENSP00000325958; ENSG00000110536. [Q8WUK0-1]
ENST00000426530; ENSP00000410272; ENSG00000110536. [Q8WUK0-3]
GeneIDi114971.
KEGGihsa:114971.
UCSCiuc001nfs.4. human. [Q8WUK0-1]
uc009ylt.3. human. [Q8WUK0-2]

Organism-specific databases

CTDi114971.
GeneCardsiGC11P047586.
HGNCiHGNC:26965. PTPMT1.
HPAiHPA043932.
MIMi609538. gene.
neXtProtiNX_Q8WUK0.
PharmGKBiPA142671115.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG146651.
GeneTreeiENSGT00390000014065.
HOGENOMiHOG000220855.
HOVERGENiHBG079822.
InParanoidiQ8WUK0.
KOiK14165.
OMAiNASCGRM.
OrthoDBiEOG7KDFCN.
PhylomeDBiQ8WUK0.
TreeFamiTF319745.

Enzyme and pathway databases

UniPathwayiUPA00084; UER00504.
BioCyciMetaCyc:HS03319-MONOMER.
ReactomeiREACT_121280. Synthesis of PG.

Miscellaneous databases

ChiTaRSiPTPMT1. human.
GenomeRNAii114971.
NextBioi79464.
PROiQ8WUK0.
SOURCEiSearch...

Gene expression databases

BgeeiQ8WUK0.
CleanExiHS_PTPMT1.
ExpressionAtlasiQ8WUK0. baseline and differential.
GenevestigatoriQ8WUK0.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Lin L., Ke R., Li H., Zhou G., Shen C., Yu R., Zhong G., Xiao W., Li M., Yang S.
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: Cervix, Kidney and Kidney adenocarcinoma.
  4. "Human acute promyelocytic leukemia cell line NB4's apoptosis/differentiation related genes."
    Yu W.-Q., Sun B.-Z., Chai Y.-B., Zhu F., Liu X.-S., Li Z., Lu F., Yan W., Yang H., Zhao Z.-L.
    Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 68-201 (ISOFORM 2).
    Tissue: Promyelocytic leukemia.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPTPM1_HUMAN
AccessioniPrimary (citable) accession number: Q8WUK0
Secondary accession number(s): E9PAT8
, Q7Z557, Q96CR2, Q9BXV8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: March 1, 2002
Last modified: February 4, 2015
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.