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Protein

Neuferricin

Gene

CYB5D2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Heme-binding protein which promotes neuronal but not astrocyte differentiation.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Neuferricin
Alternative name(s):
Cytochrome b5 domain-containing protein 2
Gene namesi
Name:CYB5D2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:28471. CYB5D2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672059.

Polymorphism and mutation databases

BioMutaiCYB5D2.
DMDMi74730719.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 264242NeuferricinPRO_0000312321Add
BLAST

Proteomic databases

EPDiQ8WUJ1.
MaxQBiQ8WUJ1.
PaxDbiQ8WUJ1.
PeptideAtlasiQ8WUJ1.
PRIDEiQ8WUJ1.

PTM databases

iPTMnetiQ8WUJ1.
PhosphoSiteiQ8WUJ1.

Expressioni

Gene expression databases

BgeeiENSG00000167740.
CleanExiHS_CYB5D2.
ExpressionAtlasiQ8WUJ1. baseline and differential.
GenevisibleiQ8WUJ1. HS.

Organism-specific databases

HPAiHPA042299.

Interactioni

Protein-protein interaction databases

BioGridi125902. 14 interactions.
STRINGi9606.ENSP00000301391.

Structurei

3D structure databases

ProteinModelPortaliQ8WUJ1.
SMRiQ8WUJ1. Positions 38-133.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 134100Cytochrome b5 heme-bindingAdd
BLAST

Domaini

The cytochrome b5 heme-binding domain was proven to bind heme, although it lacks the conserved iron-binding His residues at position 73 and 106.By similarity

Sequence similaritiesi

Belongs to the cytochrome b5 family. MAPR subfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1108. Eukaryota.
ENOG4111JSU. LUCA.
GeneTreeiENSGT00730000110948.
HOGENOMiHOG000012760.
HOVERGENiHBG105428.
InParanoidiQ8WUJ1.
OMAiGWWGPRA.
OrthoDBiEOG091G0FYY.
PhylomeDBiQ8WUJ1.
TreeFamiTF313943.

Family and domain databases

Gene3Di3.10.120.10. 1 hit.
InterProiIPR001199. Cyt_B5-like_heme/steroid-bd.
[Graphical view]
PfamiPF00173. Cyt-b5. 1 hit.
[Graphical view]
SMARTiSM01117. Cyt-b5. 1 hit.
[Graphical view]
SUPFAMiSSF55856. SSF55856. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WUJ1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLRCGGRGLL LGLAVAAAAV MAARLMGWWG PRAGFRLFIP EELSRYRGGP
60 70 80 90 100
GDPGLYLALL GRVYDVSSGR RHYEPGSHYS GFAGRDASRA FVTGDCSEAG
110 120 130 140 150
LVDDVSDLSA AEMLTLHNWL SFYEKNYVCV GRVTGRFYGE DGLPTPALTQ
160 170 180 190 200
VEAAITRGLE ANKLQLQEKQ TFPPCNAEWS SARGSRLWCS QKSGGVSRDW
210 220 230 240 250
IGVPRKLYKP GAKEPRCVCV RTTGPPSGQM PDNPPHRNRG DLDHPNLAEY
260
TGCPPLAITC SFPL
Length:264
Mass (Da):28,690
Last modified:March 1, 2002 - v1
Checksum:iD2AD67455D053882
GO
Isoform 2 (identifier: Q8WUJ1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-112: Missing.

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:152
Mass (Da):16,858
Checksum:iC2079EC359C27832
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti7 – 71R → G in a colorectal cancer sample; somatic mutation. 1 Publication
Corresponds to variant rs200936057 [ dbSNP | Ensembl ].
VAR_037487
Natural varianti7 – 71R → P in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_037488

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 112112Missing in isoform 2. CuratedVSP_045028Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK172844 mRNA. Translation: BAD18808.1.
AK313088 mRNA. Translation: BAG35913.1.
AC087292 Genomic DNA. No translation available.
CH471108 Genomic DNA. Translation: EAW90452.1.
CH471108 Genomic DNA. Translation: EAW90453.1.
CH471108 Genomic DNA. Translation: EAW90454.1.
BC020263 mRNA. Translation: AAH20263.1.
BC051697 mRNA. Translation: AAH51697.1.
CCDSiCCDS11044.1. [Q8WUJ1-1]
CCDS58501.1. [Q8WUJ1-3]
RefSeqiNP_001241684.1. NM_001254755.1. [Q8WUJ1-3]
NP_001241685.1. NM_001254756.1. [Q8WUJ1-3]
NP_653212.1. NM_144611.3. [Q8WUJ1-1]
XP_011521951.1. XM_011523649.2. [Q8WUJ1-3]
UniGeneiHs.513871.

Genome annotation databases

EnsembliENST00000301391; ENSP00000301391; ENSG00000167740. [Q8WUJ1-1]
ENST00000575251; ENSP00000458903; ENSG00000167740. [Q8WUJ1-3]
ENST00000577075; ENSP00000458352; ENSG00000167740. [Q8WUJ1-3]
GeneIDi124936.
KEGGihsa:124936.
UCSCiuc002fxl.6. human. [Q8WUJ1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK172844 mRNA. Translation: BAD18808.1.
AK313088 mRNA. Translation: BAG35913.1.
AC087292 Genomic DNA. No translation available.
CH471108 Genomic DNA. Translation: EAW90452.1.
CH471108 Genomic DNA. Translation: EAW90453.1.
CH471108 Genomic DNA. Translation: EAW90454.1.
BC020263 mRNA. Translation: AAH20263.1.
BC051697 mRNA. Translation: AAH51697.1.
CCDSiCCDS11044.1. [Q8WUJ1-1]
CCDS58501.1. [Q8WUJ1-3]
RefSeqiNP_001241684.1. NM_001254755.1. [Q8WUJ1-3]
NP_001241685.1. NM_001254756.1. [Q8WUJ1-3]
NP_653212.1. NM_144611.3. [Q8WUJ1-1]
XP_011521951.1. XM_011523649.2. [Q8WUJ1-3]
UniGeneiHs.513871.

3D structure databases

ProteinModelPortaliQ8WUJ1.
SMRiQ8WUJ1. Positions 38-133.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125902. 14 interactions.
STRINGi9606.ENSP00000301391.

PTM databases

iPTMnetiQ8WUJ1.
PhosphoSiteiQ8WUJ1.

Polymorphism and mutation databases

BioMutaiCYB5D2.
DMDMi74730719.

Proteomic databases

EPDiQ8WUJ1.
MaxQBiQ8WUJ1.
PaxDbiQ8WUJ1.
PeptideAtlasiQ8WUJ1.
PRIDEiQ8WUJ1.

Protocols and materials databases

DNASUi124936.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301391; ENSP00000301391; ENSG00000167740. [Q8WUJ1-1]
ENST00000575251; ENSP00000458903; ENSG00000167740. [Q8WUJ1-3]
ENST00000577075; ENSP00000458352; ENSG00000167740. [Q8WUJ1-3]
GeneIDi124936.
KEGGihsa:124936.
UCSCiuc002fxl.6. human. [Q8WUJ1-1]

Organism-specific databases

CTDi124936.
GeneCardsiCYB5D2.
HGNCiHGNC:28471. CYB5D2.
HPAiHPA042299.
neXtProtiNX_Q8WUJ1.
PharmGKBiPA142672059.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1108. Eukaryota.
ENOG4111JSU. LUCA.
GeneTreeiENSGT00730000110948.
HOGENOMiHOG000012760.
HOVERGENiHBG105428.
InParanoidiQ8WUJ1.
OMAiGWWGPRA.
OrthoDBiEOG091G0FYY.
PhylomeDBiQ8WUJ1.
TreeFamiTF313943.

Miscellaneous databases

ChiTaRSiCYB5D2. human.
GenomeRNAii124936.
PROiQ8WUJ1.

Gene expression databases

BgeeiENSG00000167740.
CleanExiHS_CYB5D2.
ExpressionAtlasiQ8WUJ1. baseline and differential.
GenevisibleiQ8WUJ1. HS.

Family and domain databases

Gene3Di3.10.120.10. 1 hit.
InterProiIPR001199. Cyt_B5-like_heme/steroid-bd.
[Graphical view]
PfamiPF00173. Cyt-b5. 1 hit.
[Graphical view]
SMARTiSM01117. Cyt-b5. 1 hit.
[Graphical view]
SUPFAMiSSF55856. SSF55856. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNEUFC_HUMAN
AccessioniPrimary (citable) accession number: Q8WUJ1
Secondary accession number(s): B2R7R6, D3DTJ9, I3L1K2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: March 1, 2002
Last modified: September 7, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.