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Protein

Serine/threonine/tyrosine-interacting protein

Gene

STYX

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytically inactive phosphatase. Acts as a nuclear anchor for MAPK1/MAPK3 (ERK1/ERK2). Modulates cell-fate decisions and cell migration by spatiotemporal regulation of MAPK1/MAPK3 (ERK1/ERK2). Seems to play a role in spermiogenesis (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • MAPK export from nucleus Source: UniProtKB
  • regulation of ERK1 and ERK2 cascade Source: UniProtKB
  • spermatogenesis Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Enzyme and pathway databases

BioCyciZFISH:G66-30739-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine/tyrosine-interacting protein
Alternative name(s):
Protein tyrosine phosphatase-like protein
Gene namesi
Name:STYX
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:11447. STYX.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • cytosol Source: UniProtKB-SubCell
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi120G → C: Dephosphorylates MAPK1. 1 Publication1

Organism-specific databases

DisGeNETi6815.
OpenTargetsiENSG00000198252.
PharmGKBiPA36244.

Polymorphism and mutation databases

BioMutaiSTYX.
DMDMi29840812.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000949501 – 223Serine/threonine/tyrosine-interacting proteinAdd BLAST223

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei184PhosphoserineCombined sources1
Modified residuei193PhosphoserineCombined sources1
Modified residuei201PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8WUJ0.
MaxQBiQ8WUJ0.
PaxDbiQ8WUJ0.
PeptideAtlasiQ8WUJ0.
PRIDEiQ8WUJ0.

PTM databases

DEPODiQ8WUJ0.
iPTMnetiQ8WUJ0.
PhosphoSitePlusiQ8WUJ0.

Expressioni

Gene expression databases

BgeeiENSG00000198252.
CleanExiHS_STYX.
ExpressionAtlasiQ8WUJ0. baseline and differential.
GenevisibleiQ8WUJ0. HS.

Organism-specific databases

HPAiHPA040290.
HPA040639.

Interactioni

Subunit structurei

Interacts with MAPK1; independently of MAPK1 phosphorylation status. Interacts with CARHSP1/Crhsp-24 (By similarity).By similarity

Protein-protein interaction databases

BioGridi112684. 1 interactor.
STRINGi9606.ENSP00000346599.

Structurei

Secondary structure

1223
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi30 – 33Combined sources4
Beta strandi36 – 39Combined sources4
Helixi41 – 44Combined sources4
Helixi46 – 48Combined sources3
Helixi49 – 54Combined sources6
Beta strandi59 – 64Combined sources6
Helixi66 – 68Combined sources3
Turni69 – 71Combined sources3
Turni77 – 79Combined sources3
Beta strandi80 – 86Combined sources7
Helixi96 – 98Combined sources3
Helixi99 – 111Combined sources13
Beta strandi116 – 119Combined sources4
Beta strandi121 – 125Combined sources5
Helixi126 – 139Combined sources14
Helixi143 – 153Combined sources11
Helixi161 – 175Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2R0BX-ray1.60A26-177[»]
ProteinModelPortaliQ8WUJ0.
SMRiQ8WUJ0.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8WUJ0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini96 – 167Tyrosine-protein phosphataseAdd BLAST72

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1716. Eukaryota.
COG2453. LUCA.
GeneTreeiENSGT00760000118853.
HOGENOMiHOG000090240.
HOVERGENiHBG044540.
InParanoidiQ8WUJ0.
KOiK18042.
OMAiWAYPMRR.
OrthoDBiEOG091G0249.
PhylomeDBiQ8WUJ0.
TreeFamiTF350439.

Family and domain databases

CDDicd00127. DSPc. 1 hit.
Gene3Di3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. TYR_PHOSPHATASE_dom.
IPR020422. TYR_PHOSPHATASE_DUAL_dom.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
SMARTiSM00195. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WUJ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDVKLEFPS LPQCKEDAEE WTYPMRREMQ EILPGLFLGP YSSAMKSKLP
60 70 80 90 100
VLQKHGITHI ICIRQNIEAN FIKPNFQQLF RYLVLDIADN PVENIIRFFP
110 120 130 140 150
MTKEFIDGSL QMGGKVLVHG NAGISRSAAF VIAYIMETFG MKYRDAFAYV
160 170 180 190 200
QERRFCINPN AGFVHQLQEY EAIYLAKLTI QMMSPLQIER SLSVHSGTTG
210 220
SLKRTHEEED DFGTMQVATA QNG
Length:223
Mass (Da):25,492
Last modified:March 1, 2002 - v1
Checksum:iD2C8D05104073EE8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK098195 mRNA. Translation: BAC05259.1.
CH471078 Genomic DNA. Translation: EAW65641.1.
CH471078 Genomic DNA. Translation: EAW65644.1.
CH471061 Genomic DNA. Translation: EAW80612.1.
BC020265 mRNA. Translation: AAH20265.1.
BC146995 mRNA. Translation: AAI46996.1.
BC146998 mRNA. Translation: AAI46999.1.
U87169 mRNA. Translation: AAB47561.1.
CCDSiCCDS9711.1.
RefSeqiNP_001124173.1. NM_001130701.1.
NP_660294.1. NM_145251.3.
UniGeneiHs.364980.

Genome annotation databases

EnsembliENST00000354586; ENSP00000346599; ENSG00000198252.
ENST00000442123; ENSP00000403214; ENSG00000198252.
GeneIDi6815.
KEGGihsa:6815.
UCSCiuc001xaa.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK098195 mRNA. Translation: BAC05259.1.
CH471078 Genomic DNA. Translation: EAW65641.1.
CH471078 Genomic DNA. Translation: EAW65644.1.
CH471061 Genomic DNA. Translation: EAW80612.1.
BC020265 mRNA. Translation: AAH20265.1.
BC146995 mRNA. Translation: AAI46996.1.
BC146998 mRNA. Translation: AAI46999.1.
U87169 mRNA. Translation: AAB47561.1.
CCDSiCCDS9711.1.
RefSeqiNP_001124173.1. NM_001130701.1.
NP_660294.1. NM_145251.3.
UniGeneiHs.364980.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2R0BX-ray1.60A26-177[»]
ProteinModelPortaliQ8WUJ0.
SMRiQ8WUJ0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112684. 1 interactor.
STRINGi9606.ENSP00000346599.

PTM databases

DEPODiQ8WUJ0.
iPTMnetiQ8WUJ0.
PhosphoSitePlusiQ8WUJ0.

Polymorphism and mutation databases

BioMutaiSTYX.
DMDMi29840812.

Proteomic databases

EPDiQ8WUJ0.
MaxQBiQ8WUJ0.
PaxDbiQ8WUJ0.
PeptideAtlasiQ8WUJ0.
PRIDEiQ8WUJ0.

Protocols and materials databases

DNASUi6815.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354586; ENSP00000346599; ENSG00000198252.
ENST00000442123; ENSP00000403214; ENSG00000198252.
GeneIDi6815.
KEGGihsa:6815.
UCSCiuc001xaa.4. human.

Organism-specific databases

CTDi6815.
DisGeNETi6815.
GeneCardsiSTYX.
HGNCiHGNC:11447. STYX.
HPAiHPA040290.
HPA040639.
MIMi615814. gene.
neXtProtiNX_Q8WUJ0.
OpenTargetsiENSG00000198252.
PharmGKBiPA36244.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1716. Eukaryota.
COG2453. LUCA.
GeneTreeiENSGT00760000118853.
HOGENOMiHOG000090240.
HOVERGENiHBG044540.
InParanoidiQ8WUJ0.
KOiK18042.
OMAiWAYPMRR.
OrthoDBiEOG091G0249.
PhylomeDBiQ8WUJ0.
TreeFamiTF350439.

Enzyme and pathway databases

BioCyciZFISH:G66-30739-MONOMER.

Miscellaneous databases

ChiTaRSiSTYX. human.
EvolutionaryTraceiQ8WUJ0.
GenomeRNAii6815.
PROiQ8WUJ0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198252.
CleanExiHS_STYX.
ExpressionAtlasiQ8WUJ0. baseline and differential.
GenevisibleiQ8WUJ0. HS.

Family and domain databases

CDDicd00127. DSPc. 1 hit.
Gene3Di3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. TYR_PHOSPHATASE_dom.
IPR020422. TYR_PHOSPHATASE_DUAL_dom.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
SMARTiSM00195. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSTYX_HUMAN
AccessioniPrimary (citable) accession number: Q8WUJ0
Secondary accession number(s): B9EJG0, Q99850
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: March 1, 2002
Last modified: November 30, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Contains a Gly residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase. The binding pocket is however sufficiently preserved to bind phosphorylated substrates, and maybe protect them from phosphatases.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.