##gff-version 3 Q8WUI4 UniProtKB Chain 1 952 . . . ID=PRO_0000114705;Note=Histone deacetylase 7 Q8WUI4 UniProtKB Region 1 268 . . . Note=Transcription repression 1;Ontology_term=ECO:0000250;evidence=ECO:0000250 Q8WUI4 UniProtKB Region 1 98 . . . Note=Interaction with MEF2C;Ontology_term=ECO:0000250;evidence=ECO:0000250 Q8WUI4 UniProtKB Region 49 149 . . . Note=Interaction with MEF2A;Ontology_term=ECO:0000250;evidence=ECO:0000250 Q8WUI4 UniProtKB Region 130 224 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q8WUI4 UniProtKB Region 218 546 . . . Note=Transcription repression 2;Ontology_term=ECO:0000250;evidence=ECO:0000250 Q8WUI4 UniProtKB Region 261 283 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q8WUI4 UniProtKB Region 349 377 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q8WUI4 UniProtKB Region 389 441 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q8WUI4 UniProtKB Region 460 510 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q8WUI4 UniProtKB Region 518 865 . . . Note=Histone deacetylase Q8WUI4 UniProtKB Region 877 952 . . . Note=Interaction with SIN3A;Ontology_term=ECO:0000250;evidence=ECO:0000250 Q8WUI4 UniProtKB Motif 918 952 . . . Note=Nuclear export signal;Ontology_term=ECO:0000250;evidence=ECO:0000250 Q8WUI4 UniProtKB Compositional bias 194 218 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q8WUI4 UniProtKB Compositional bias 362 376 . . . Note=Pro residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q8WUI4 UniProtKB Compositional bias 389 406 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q8WUI4 UniProtKB Active site 670 670 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 Q8WUI4 UniProtKB Binding site 533 533 . . . . Q8WUI4 UniProtKB Binding site 535 535 . . . . Q8WUI4 UniProtKB Binding site 541 541 . . . . Q8WUI4 UniProtKB Binding site 618 618 . . . . Q8WUI4 UniProtKB Site 843 843 . . . Note=Contributes to catalysis Q8WUI4 UniProtKB Modified residue 109 109 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:23186163;Dbxref=PMID:18669648,PMID:23186163 Q8WUI4 UniProtKB Modified residue 155 155 . . . Note=Phosphoserine%3B by MARK2%2C MARK3 and PKD/PRKD1;Ontology_term=ECO:0000305;evidence=ECO:0000305|PubMed:16980613;Dbxref=PMID:16980613 Q8WUI4 UniProtKB Modified residue 181 181 . . . Note=Phosphoserine%3B by PKD/PRKD2;Ontology_term=ECO:0000269,ECO:0000269,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0000269|PubMed:16980613,ECO:0000269|PubMed:17962809,ECO:0007744|PubMed:20068231,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163;Dbxref=PMID:16980613,PMID:17962809,PMID:20068231,PMID:21406692,PMID:23186163 Q8WUI4 UniProtKB Modified residue 283 283 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231 Q8WUI4 UniProtKB Modified residue 286 286 . . . Note=Phosphothreonine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:20068231;Dbxref=PMID:18669648,PMID:20068231 Q8WUI4 UniProtKB Modified residue 358 358 . . . Note=Phosphoserine%3B by PKD/PRKD1;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q8C2B3 Q8WUI4 UniProtKB Modified residue 364 364 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:24275569;Dbxref=PMID:24275569 Q8WUI4 UniProtKB Modified residue 405 405 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q8WUI4 UniProtKB Modified residue 486 486 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:18669648,ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:21406692,ECO:0007744|PubMed:23186163,ECO:0007744|PubMed:24275569;Dbxref=PMID:18669648,PMID:19690332,PMID:21406692,PMID:23186163,PMID:24275569 Q8WUI4 UniProtKB Modified residue 487 487 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q8WUI4 UniProtKB Modified residue 507 507 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q8WUI4 UniProtKB Modified residue 595 595 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23186163;Dbxref=PMID:23186163 Q8WUI4 UniProtKB Alternative sequence 1 527 . . . ID=VSP_038102;Note=In isoform 9. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 Q8WUI4 UniProtKB Alternative sequence 1 472 . . . ID=VSP_007429;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 Q8WUI4 UniProtKB Alternative sequence 1 338 . . . ID=VSP_038103;Note=In isoform 10. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|Ref.4 Q8WUI4 UniProtKB Alternative sequence 1 1 . . . ID=VSP_038104;Note=In isoform 5 and isoform 7. M->MHSPGADGTQVSPGAHYCSPTGAGCPRPCADTPGPQPQPM;Ontology_term=ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334;Dbxref=PMID:14702039,PMID:15489334 Q8WUI4 UniProtKB Alternative sequence 1 1 . . . ID=VSP_038105;Note=In isoform 6. M->MHSPGAGCPRPCADTPGPQPQPM;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 Q8WUI4 UniProtKB Alternative sequence 1 1 . . . ID=VSP_038106;Note=In isoform 8. M->MSDLRKRELGALFTSRGTGGVEWDGTQVSPGAHYCSPTGAGCPRPCADTPGPQPQPM;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 Q8WUI4 UniProtKB Alternative sequence 227 263 . . . ID=VSP_008772;Note=In isoform 3 and isoform 7. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:14702039,ECO:0000303|PubMed:15489334,ECO:0000303|Ref.3;Dbxref=PMID:14702039,PMID:15489334 Q8WUI4 UniProtKB Alternative sequence 227 256 . . . ID=VSP_007430;Note=In isoform 4. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q8WUI4 UniProtKB Alternative sequence 473 520 . . . ID=VSP_007431;Note=In isoform 2. LAQGGHRPLSRAQSSPAAPASLSAPEPASQARVLSSSETPARTLPFTT->MQACVGVRGVYPPGSMWVPAVAVLACSLQPRPWGVRTPWVPALTLAPA;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 Q8WUI4 UniProtKB Alternative sequence 892 952 . . . ID=VSP_038107;Note=In isoform 8. SKYWGCMQRLASCPDSWVPRVPGADKEEVEAVTALASLSVGILAEDRPSEQLVEEEEPMNL->MGALTLSQIPGHGSSQQQAGGAFSRPGHPCRAAVVMVNTGAACSAWPPVQTPGCLECQGLTKKKWRQ;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:14702039;Dbxref=PMID:14702039 Q8WUI4 UniProtKB Natural variant 43 43 . . . ID=VAR_036043;Note=In a breast cancer sample%3B somatic mutation. V->M;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=dbSNP:rs1165948169,PMID:16959974 Q8WUI4 UniProtKB Mutagenesis 150 150 . . . Note=Abolishes phosphorylation at S-155. L->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16980613;Dbxref=PMID:16980613 Q8WUI4 UniProtKB Mutagenesis 155 155 . . . Note=Abolishes nuclear export%3B when associated with A-181%3B A-358 and A-486. Abolishes phosphorylation by MARK2 and MARK3%2C interaction with 14-3-3 and localization to the cytoplasm. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16980613;Dbxref=PMID:16980613 Q8WUI4 UniProtKB Mutagenesis 181 181 . . . Note=Abolishes nuclear export%3B when associated with A-155%3B A-358 and A-486. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16980613;Dbxref=PMID:16980613 Q8WUI4 UniProtKB Mutagenesis 358 358 . . . Note=Abolishes nuclear export%3B when associated with A-192%3B A-1118 and A-486. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16980613;Dbxref=PMID:16980613 Q8WUI4 UniProtKB Mutagenesis 486 486 . . . Note=Abolishes nuclear export%3B when associated with A-192%3B A-1118 and A-358. S->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16980613;Dbxref=PMID:16980613 Q8WUI4 UniProtKB Mutagenesis 843 843 . . . Note=Enhanced deacetylase activity. H->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18285338;Dbxref=PMID:18285338 Q8WUI4 UniProtKB Mutagenesis 843 843 . . . Note=Enhanced deacetylase activity. H->F;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18285338;Dbxref=PMID:18285338 Q8WUI4 UniProtKB Mutagenesis 843 843 . . . Note=6000 fold increase in deacetylase activity. H->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:18285338;Dbxref=PMID:18285338 Q8WUI4 UniProtKB Sequence conflict 50 50 . . . Note=M->T;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q8WUI4 UniProtKB Sequence conflict 225 264 . . . Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q8WUI4 UniProtKB Sequence conflict 276 276 . . . Note=P->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q8WUI4 UniProtKB Sequence conflict 561 561 . . . Note=R->L;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q8WUI4 UniProtKB Sequence conflict 614 614 . . . Note=V->E;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q8WUI4 UniProtKB Sequence conflict 644 644 . . . Note=S->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q8WUI4 UniProtKB Sequence conflict 665 665 . . . Note=R->W;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q8WUI4 UniProtKB Sequence conflict 700 700 . . . Note=K->KASK;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q8WUI4 UniProtKB Sequence conflict 750 750 . . . Note=G->S;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q8WUI4 UniProtKB Sequence conflict 777 777 . . . Note=A->T;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q8WUI4 UniProtKB Sequence conflict 825 825 . . . Note=Q->H;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q8WUI4 UniProtKB Beta strand 520 523 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3C10 Q8WUI4 UniProtKB Helix 526 530 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3C10 Q8WUI4 UniProtKB Helix 538 540 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3C10 Q8WUI4 UniProtKB Helix 546 557 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3C10 Q8WUI4 UniProtKB Helix 561 563 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3C10 Q8WUI4 UniProtKB Beta strand 564 567 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3C10 Q8WUI4 UniProtKB Helix 574 577 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3C10 Q8WUI4 UniProtKB Turn 578 580 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3C10 Q8WUI4 UniProtKB Helix 583 590 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3C10 Q8WUI4 UniProtKB Helix 601 609 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3C10 Q8WUI4 UniProtKB Beta strand 621 626 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3C10 Q8WUI4 UniProtKB Turn 631 633 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3C10 Q8WUI4 UniProtKB Helix 634 653 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3C10 Q8WUI4 UniProtKB Beta strand 656 662 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3C10 Q8WUI4 UniProtKB Beta strand 680 682 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3C10 Q8WUI4 UniProtKB Helix 684 695 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3C10 Q8WUI4 UniProtKB Beta strand 701 705 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3C10 Q8WUI4 UniProtKB Beta strand 707 709 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3C10 Q8WUI4 UniProtKB Helix 712 718 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3C10 Q8WUI4 UniProtKB Beta strand 724 731 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3C10 Q8WUI4 UniProtKB Turn 733 736 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3C10 Q8WUI4 UniProtKB Helix 750 752 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3C10 Q8WUI4 UniProtKB Beta strand 756 761 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3C10 Q8WUI4 UniProtKB Beta strand 765 767 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3C10 Q8WUI4 UniProtKB Helix 771 780 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3C10 Q8WUI4 UniProtKB Helix 782 789 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3C10 Q8WUI4 UniProtKB Beta strand 792 798 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3C10 Q8WUI4 UniProtKB Helix 808 810 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3C10 Q8WUI4 UniProtKB Helix 817 827 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3C10 Q8WUI4 UniProtKB Helix 831 833 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3C10 Q8WUI4 UniProtKB Beta strand 835 839 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3C10 Q8WUI4 UniProtKB Helix 845 860 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3C10 Q8WUI4 UniProtKB Helix 866 868 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3C10 Q8WUI4 UniProtKB Helix 871 873 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3C10 Q8WUI4 UniProtKB Helix 878 891 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3C10 Q8WUI4 UniProtKB Turn 892 894 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3C10 Q8WUI4 UniProtKB Helix 896 898 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:3C10