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Protein

Transmembrane protein 263

Gene

TMEM263

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 263
Gene namesi
Name:TMEM263
Synonyms:C12orf23
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:28281. TMEM263.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei40 – 6021HelicalSequence analysisAdd
BLAST
Transmembranei78 – 9821HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672295.

Polymorphism and mutation databases

BioMutaiC12orf23.
DMDMi74730713.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 116116Transmembrane protein 263PRO_0000263629Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi2 – 21N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ8WUH6.
MaxQBiQ8WUH6.
PaxDbiQ8WUH6.
PeptideAtlasiQ8WUH6.
PRIDEiQ8WUH6.
TopDownProteomicsiQ8WUH6.

PTM databases

iPTMnetiQ8WUH6.
PhosphoSiteiQ8WUH6.
SwissPalmiQ8WUH6.

Expressioni

Gene expression databases

BgeeiQ8WUH6.
CleanExiHS_C12orf23.
ExpressionAtlasiQ8WUH6. baseline and differential.
GenevisibleiQ8WUH6. HS.

Organism-specific databases

HPAiHPA042339.

Interactioni

Protein-protein interaction databases

BioGridi124723. 16 interactions.
IntActiQ8WUH6. 15 interactions.
STRINGi9606.ENSP00000280756.

Structurei

3D structure databases

ProteinModelPortaliQ8WUH6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM263 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IXK4. Eukaryota.
ENOG4111SH7. LUCA.
GeneTreeiENSGT00390000013899.
HOGENOMiHOG000060332.
HOVERGENiHBG058969.
InParanoidiQ8WUH6.
OMAiSKVPIGG.
OrthoDBiEOG7WHHCZ.
PhylomeDBiQ8WUH6.
TreeFamiTF333298.

Family and domain databases

InterProiIPR028153. UPF0444.
[Graphical view]
PANTHERiPTHR31443:SF0. PTHR31443:SF0. 1 hit.
PfamiPF15475. UPF0444. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WUH6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNQTDKNQQE IPSYLNDEPP EGSMKDHPQQ QPGMLSRVTG GIFSVTKGAV
60 70 80 90 100
GATIGGVAWI GGKSLEVTKT AVTTVPSMGI GLVKGGVSAV AGGVTAVGSA
110
VVNKVPLTGK KKDKSD
Length:116
Mass (Da):11,748
Last modified:March 1, 2002 - v1
Checksum:iA40412A1683989FF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK021783 mRNA. Translation: BAG51051.1.
AK022770 mRNA. Translation: BAG51112.1.
AK024021 mRNA. Translation: BAG51252.1.
CH471054 Genomic DNA. Translation: EAW97790.1.
BC020522 mRNA. Translation: AAH20522.1.
CCDSiCCDS9110.1.
RefSeqiNP_001306590.1. NM_001319661.1.
NP_001306591.1. NM_001319662.1.
NP_001306592.1. NM_001319663.1.
NP_001306593.1. NM_001319664.1.
NP_001306595.1. NM_001319666.1.
NP_689474.1. NM_152261.3.
UniGeneiHs.257664.

Genome annotation databases

EnsembliENST00000280756; ENSP00000280756; ENSG00000151135.
ENST00000547081; ENSP00000449106; ENSG00000151135.
ENST00000547242; ENSP00000446537; ENSG00000151135.
ENST00000548125; ENSP00000449785; ENSG00000151135.
ENST00000550344; ENSP00000446717; ENSG00000151135.
ENST00000551813; ENSP00000450350; ENSG00000151135.
GeneIDi90488.
KEGGihsa:90488.
UCSCiuc001tmb.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK021783 mRNA. Translation: BAG51051.1.
AK022770 mRNA. Translation: BAG51112.1.
AK024021 mRNA. Translation: BAG51252.1.
CH471054 Genomic DNA. Translation: EAW97790.1.
BC020522 mRNA. Translation: AAH20522.1.
CCDSiCCDS9110.1.
RefSeqiNP_001306590.1. NM_001319661.1.
NP_001306591.1. NM_001319662.1.
NP_001306592.1. NM_001319663.1.
NP_001306593.1. NM_001319664.1.
NP_001306595.1. NM_001319666.1.
NP_689474.1. NM_152261.3.
UniGeneiHs.257664.

3D structure databases

ProteinModelPortaliQ8WUH6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124723. 16 interactions.
IntActiQ8WUH6. 15 interactions.
STRINGi9606.ENSP00000280756.

PTM databases

iPTMnetiQ8WUH6.
PhosphoSiteiQ8WUH6.
SwissPalmiQ8WUH6.

Polymorphism and mutation databases

BioMutaiC12orf23.
DMDMi74730713.

Proteomic databases

EPDiQ8WUH6.
MaxQBiQ8WUH6.
PaxDbiQ8WUH6.
PeptideAtlasiQ8WUH6.
PRIDEiQ8WUH6.
TopDownProteomicsiQ8WUH6.

Protocols and materials databases

DNASUi90488.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000280756; ENSP00000280756; ENSG00000151135.
ENST00000547081; ENSP00000449106; ENSG00000151135.
ENST00000547242; ENSP00000446537; ENSG00000151135.
ENST00000548125; ENSP00000449785; ENSG00000151135.
ENST00000550344; ENSP00000446717; ENSG00000151135.
ENST00000551813; ENSP00000450350; ENSG00000151135.
GeneIDi90488.
KEGGihsa:90488.
UCSCiuc001tmb.4. human.

Organism-specific databases

CTDi90488.
GeneCardsiTMEM263.
H-InvDBHIX0010957.
HGNCiHGNC:28281. TMEM263.
HPAiHPA042339.
neXtProtiNX_Q8WUH6.
PharmGKBiPA142672295.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IXK4. Eukaryota.
ENOG4111SH7. LUCA.
GeneTreeiENSGT00390000013899.
HOGENOMiHOG000060332.
HOVERGENiHBG058969.
InParanoidiQ8WUH6.
OMAiSKVPIGG.
OrthoDBiEOG7WHHCZ.
PhylomeDBiQ8WUH6.
TreeFamiTF333298.

Miscellaneous databases

GenomeRNAii90488.
PROiQ8WUH6.

Gene expression databases

BgeeiQ8WUH6.
CleanExiHS_C12orf23.
ExpressionAtlasiQ8WUH6. baseline and differential.
GenevisibleiQ8WUH6. HS.

Family and domain databases

InterProiIPR028153. UPF0444.
[Graphical view]
PANTHERiPTHR31443:SF0. PTHR31443:SF0. 1 hit.
PfamiPF15475. UPF0444. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTM263_HUMAN
AccessioniPrimary (citable) accession number: Q8WUH6
Secondary accession number(s): B3KMN9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: March 1, 2002
Last modified: June 8, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.