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Protein

Transforming growth factor-beta receptor-associated protein 1

Gene

TGFBRAP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling. May recruit SMAD4 to the vicinity of the receptor complex and facilitate its interaction with receptor-regulated Smads, such as SMAD2.2 Publications

GO - Molecular functioni

  • SMAD binding Source: UniProtKB
  • transforming growth factor beta receptor binding Source: UniProtKB

GO - Biological processi

  • intracellular protein transport Source: InterPro
  • regulation of transcription, DNA-templated Source: UniProtKB
  • signal transduction Source: UniProtKB
  • transforming growth factor beta receptor signaling pathway Source: UniProtKB
  • vesicle-mediated transport Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

SignaLinkiQ8WUH2.

Names & Taxonomyi

Protein namesi
Recommended name:
Transforming growth factor-beta receptor-associated protein 1
Short name:
TGF-beta receptor-associated protein 1
Short name:
TRAP-1
Short name:
TRAP1
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:16836. TGFBRAP1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134963946.

Polymorphism and mutation databases

BioMutaiTGFBRAP1.
DMDMi74730711.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 860860Transforming growth factor-beta receptor-associated protein 1PRO_0000345405Add
BLAST

Proteomic databases

MaxQBiQ8WUH2.
PaxDbiQ8WUH2.
PRIDEiQ8WUH2.

PTM databases

PhosphoSiteiQ8WUH2.

Expressioni

Gene expression databases

BgeeiQ8WUH2.
CleanExiHS_TGFBRAP1.
GenevisibleiQ8WUH2. HS.

Organism-specific databases

HPAiHPA038397.

Interactioni

Subunit structurei

Interacts with TGFBR2 and ACVR2B; in the absence of ligand stimulation. Interacts with TGFBR1, ACVRL1, BMPR1A and ACVR1B; in the absence of ligand stimulation and to a less extent. Interacts with SMAD4; the interaction seems to be mutually exclusive with the interaction of SMAD4 and phosphorylated SMAD2. May interact with ALOX5.3 Publications

Protein-protein interaction databases

BioGridi114792. 9 interactions.
IntActiQ8WUH2. 1 interaction.
STRINGi9606.ENSP00000258449.

Structurei

3D structure databases

ProteinModelPortaliQ8WUH2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 297274CNHPROSITE-ProRule annotationAdd
BLAST
Repeati564 – 728165CHCRAdd
BLAST

Sequence similaritiesi

Belongs to the TRAP1 family.Curated
Contains 1 CHCR (clathrin heavy-chain) repeat.PROSITE-ProRule annotation
Contains 1 CNH domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG254275.
GeneTreeiENSGT00530000063596.
HOGENOMiHOG000007291.
HOVERGENiHBG108563.
InParanoidiQ8WUH2.
OMAiVECCGRD.
OrthoDBiEOG7RBZ7Q.
PhylomeDBiQ8WUH2.
TreeFamiTF328650.

Family and domain databases

InterProiIPR001180. Citron.
IPR000547. Clathrin_H-chain/VPS_repeat.
IPR019452. VPS39/TGF_beta_rcpt-assoc_1.
IPR019453. VPS39/TGF_beta_rcpt-assoc_2.
[Graphical view]
PfamiPF00637. Clathrin. 1 hit.
PF00780. CNH. 1 hit.
PF10366. Vps39_1. 1 hit.
PF10367. Vps39_2. 1 hit.
[Graphical view]
PROSITEiPS50236. CHCR. 1 hit.
PS50219. CNH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WUH2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMSIKAFTLV SAVERELLMG DKERVNIECV ECCGRDLYVG TNDCFVYHFL
60 70 80 90 100
LEERPVPAGP ATFTATKQLQ RHLGFKKPVN ELRAASALNR LLVLCDNSIS
110 120 130 140 150
LVNMLNLEPV PSGARIKGAA TFALNENPVS GDPFCVEVCI ISVKRRTIQM
160 170 180 190 200
FLVYEDRVQI VKEVSTAEQP LAVAVDGHFL CLALTTQYII HNYSTGVSQD
210 220 230 240 250
LFPYCSEERP PIVKRIGRQE FLLAGPGGLG MFATVAGISQ RAPVHWSENV
260 270 280 290 300
IGAAVSFPYV IALDDEFITV HSMLDQQQKQ TLPFKEGHIL QDFEGRVIVA
310 320 330 340 350
TSKGVYILVP LPLEKQIQDL LASRRVEEAL VLAKGARRNI PKEKFQVMYR
360 370 380 390 400
RILQQAGFIQ FAQLQFLEAK ELFRSGQLDV RELISLYPFL LPTSSSFTRS
410 420 430 440 450
HPPLHEYADL NQLTQGDQEK MAKCKRFLMS YLNEVRSTEV ANGYKEDIDT
460 470 480 490 500
ALLKLYAEAD HDSLLDLLVT ENFCLLTDSA AWLEKHKKYF ALGLLYHYNN
510 520 530 540 550
QDAAAVQLWV NIVNGDVQDS TRSDLYEYIV DFLTYCLDEE LVWAYADWVL
560 570 580 590 600
QKSEEVGVQV FTKRPLDEQQ KNSFNPDDII NCLKKYPKAL VKYLEHLVID
610 620 630 640 650
KRLQKEEYHT HLAVLYLEEV LLQRASASGK GAEATETQAK LRRLLQKSDL
660 670 680 690 700
YRVHFLLERL QGAGLPMESA ILHGKLGEHE KALHILVHEL QDFAAAEDYC
710 720 730 740 750
LWCSEGRDPP HRQQLFHTLL AIYLHAGPTA HELAVAAVDL LNRHATEFDA
760 770 780 790 800
AQVLQMLPDT WSVQLLCPFL MGAMRDSIHA RRTMQVALGL ARSENLIYTY
810 820 830 840 850
DKMKLKGSSI QLSDKKLCQI CQNPFCEPVF VRYPNGGLVH THCAASRHTN
860
PSSSSPGTRT
Length:860
Mass (Da):97,158
Last modified:March 1, 2002 - v1
Checksum:iABDD23BEDC5F4A55
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti805 – 8051L → S in BAF84071 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti725 – 7251H → R.2 Publications
Corresponds to variant rs2241797 [ dbSNP | Ensembl ].
VAR_045822

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022795 mRNA. Translation: AAC16903.1.
AK291382 mRNA. Translation: BAF84071.1.
AC012360 Genomic DNA. Translation: AAY15010.1.
CH471127 Genomic DNA. Translation: EAX01764.1.
CH471127 Genomic DNA. Translation: EAX01765.1.
BC020548 mRNA. Translation: AAH20548.1.
CCDSiCCDS2067.1.
PIRiT08622.
RefSeqiNP_001136093.1. NM_001142621.2.
NP_004248.2. NM_004257.5.
UniGeneiHs.446350.
Hs.592796.

Genome annotation databases

EnsembliENST00000258449; ENSP00000258449; ENSG00000135966.
ENST00000393359; ENSP00000377027; ENSG00000135966.
ENST00000595531; ENSP00000471434; ENSG00000135966.
GeneIDi9392.
KEGGihsa:9392.
UCSCiuc002tcq.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF022795 mRNA. Translation: AAC16903.1.
AK291382 mRNA. Translation: BAF84071.1.
AC012360 Genomic DNA. Translation: AAY15010.1.
CH471127 Genomic DNA. Translation: EAX01764.1.
CH471127 Genomic DNA. Translation: EAX01765.1.
BC020548 mRNA. Translation: AAH20548.1.
CCDSiCCDS2067.1.
PIRiT08622.
RefSeqiNP_001136093.1. NM_001142621.2.
NP_004248.2. NM_004257.5.
UniGeneiHs.446350.
Hs.592796.

3D structure databases

ProteinModelPortaliQ8WUH2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114792. 9 interactions.
IntActiQ8WUH2. 1 interaction.
STRINGi9606.ENSP00000258449.

PTM databases

PhosphoSiteiQ8WUH2.

Polymorphism and mutation databases

BioMutaiTGFBRAP1.
DMDMi74730711.

Proteomic databases

MaxQBiQ8WUH2.
PaxDbiQ8WUH2.
PRIDEiQ8WUH2.

Protocols and materials databases

DNASUi9392.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000258449; ENSP00000258449; ENSG00000135966.
ENST00000393359; ENSP00000377027; ENSG00000135966.
ENST00000595531; ENSP00000471434; ENSG00000135966.
GeneIDi9392.
KEGGihsa:9392.
UCSCiuc002tcq.3. human.

Organism-specific databases

CTDi9392.
GeneCardsiGC02M105880.
HGNCiHGNC:16836. TGFBRAP1.
HPAiHPA038397.
MIMi606237. gene.
neXtProtiNX_Q8WUH2.
PharmGKBiPA134963946.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG254275.
GeneTreeiENSGT00530000063596.
HOGENOMiHOG000007291.
HOVERGENiHBG108563.
InParanoidiQ8WUH2.
OMAiVECCGRD.
OrthoDBiEOG7RBZ7Q.
PhylomeDBiQ8WUH2.
TreeFamiTF328650.

Enzyme and pathway databases

SignaLinkiQ8WUH2.

Miscellaneous databases

ChiTaRSiTGFBRAP1. human.
GenomeRNAii9392.
NextBioi35191.
PROiQ8WUH2.
SOURCEiSearch...

Gene expression databases

BgeeiQ8WUH2.
CleanExiHS_TGFBRAP1.
GenevisibleiQ8WUH2. HS.

Family and domain databases

InterProiIPR001180. Citron.
IPR000547. Clathrin_H-chain/VPS_repeat.
IPR019452. VPS39/TGF_beta_rcpt-assoc_1.
IPR019453. VPS39/TGF_beta_rcpt-assoc_2.
[Graphical view]
PfamiPF00637. Clathrin. 1 hit.
PF00780. CNH. 1 hit.
PF10366. Vps39_1. 1 hit.
PF10367. Vps39_2. 1 hit.
[Graphical view]
PROSITEiPS50236. CHCR. 1 hit.
PS50219. CNH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel protein distinguishes between quiescent and activated forms of the type I transforming growth factor beta receptor."
    Charng M.-J., Zhang D., Kinnunen P., Schneider M.D.
    J. Biol. Chem. 273:9365-9368(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH TGFBR1, VARIANT ARG-725.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ARG-725.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lymph.
  6. Cited for: INTERACTION WITH ALOX5.
  7. "Transforming growth factor-beta receptor-associated protein 1 is a Smad4 chaperone."
    Wurthner J.U., Frank D.B., Felici A., Green H.M., Cao Z., Schneider M.D., McNally J.G., Lechleider R.J., Roberts A.B.
    J. Biol. Chem. 276:19495-19502(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH TGFBR2; ACVR2B; TGFBR1; ACVRL1; BMPR1A; ACVR1B2 AND SMAD4, SUBCELLULAR LOCATION.
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiTGFA1_HUMAN
AccessioniPrimary (citable) accession number: Q8WUH2
Secondary accession number(s): A8K5R7, D3DVJ8, O60466
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: March 1, 2002
Last modified: July 22, 2015
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

In (PubMed:9545258) and in (PubMed:10051563) experimental information is given for a truncated version of TGFBRAP1 (sequence of 474-860), which was later shown to act as a dominant negative.2 Publications

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.