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Protein

Solute carrier family 22 member 17

Gene

SLC22A17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Ion transport, Iron transport, Transport

Keywords - Ligandi

Iron

Enzyme and pathway databases

ReactomeiR-HSA-917937. Iron uptake and transport.

Protein family/group databases

TCDBi2.A.1.19.8. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 22 member 17
Alternative name(s):
24p3 receptor
Short name:
24p3R
Brain-type organic cation transporter
Lipocalin-2 receptor
Neutrophil gelatinase-associated lipocalin receptor
Short name:
NgalR
Gene namesi
Name:SLC22A17
Synonyms:BOCT, BOIT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:23095. SLC22A17.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei100 – 12021HelicalSequence analysisAdd
BLAST
Transmembranei129 – 14921HelicalSequence analysisAdd
BLAST
Transmembranei154 – 17421HelicalSequence analysisAdd
BLAST
Transmembranei189 – 20921HelicalSequence analysisAdd
BLAST
Transmembranei219 – 23921HelicalSequence analysisAdd
BLAST
Transmembranei303 – 32220HelicalSequence analysisAdd
BLAST
Transmembranei337 – 35721HelicalSequence analysisAdd
BLAST
Transmembranei366 – 38621HelicalSequence analysisAdd
BLAST
Transmembranei415 – 43521HelicalSequence analysisAdd
BLAST
Transmembranei446 – 46621HelicalSequence analysisAdd
BLAST
Transmembranei473 – 49321HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of organelle membrane Source: UniProtKB
  • integral component of plasma membrane Source: UniProtKB
  • plasma membrane Source: Reactome
  • vacuolar membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Vacuole

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134879149.

Polymorphism and mutation databases

DMDMi27805426.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 538538Solute carrier family 22 member 17PRO_0000220507Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi23 – 231N-linked (GlcNAc...)Sequence analysis
Glycosylationi32 – 321N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8WUG5.
PRIDEiQ8WUG5.

PTM databases

PhosphoSiteiQ8WUG5.

Expressioni

Tissue specificityi

Expressed in brain.

Inductioni

Expression is activated by RUNX3. Repressed by the oncoprotein BCR-ABL; BCR-ABL misregulates expression by inducing a switch in binding from RUNX3 to RUNX1, a repressor of 24p3R expression, through a Ras signaling pathway.2 Publications

Gene expression databases

BgeeiQ8WUG5.
CleanExiHS_SLC22A17.
ExpressionAtlasiQ8WUG5. baseline and differential.
GenevisibleiQ8WUG5. HS.

Organism-specific databases

HPAiHPA002728.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000206544.

Structurei

3D structure databases

ProteinModelPortaliQ8WUG5.
SMRiQ8WUG5. Positions 97-124.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IRI7. Eukaryota.
ENOG411129W. LUCA.
GeneTreeiENSGT00390000014377.
HOVERGENiHBG031124.
InParanoidiQ8WUG5.
KOiK08213.
OMAiTRLELCE.
OrthoDBiEOG7PP56J.
PhylomeDBiQ8WUG5.
TreeFamiTF335753.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WUG5-1) [UniParc]FASTAAdd to basket

Also known as: NgalR-1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASDPIFTLA PPLHCHYGAF PPNASGWEQP PNASGVSVAS AALAASAASR
60 70 80 90 100
VATSTDPSCS GFAPPDFNHC LKDWDYNGLP VLTTNAIGQW DLVCDLGWQV
110 120 130 140 150
ILEQILFILG FASGYLFLGY PADRFGRRGI VLLTLGLVGP CGVGGAAAGS
160 170 180 190 200
STGVMALRFL LGFLLAGVDL GVYLMRLELC DPTQRLRVAL AGELVGVGGH
210 220 230 240 250
FLFLGLALVS KDWRFLQRMI TAPCILFLFY GWPGLFLESA RWLIVKRQIE
260 270 280 290 300
EAQSVLRILA ERNRPHGQML GEEAQEALQD LENTCPLPAT SSFSFASLLN
310 320 330 340 350
YRNIWKNLLI LGFTNFIAHA IRHCYQPVGG GGSPSDFYLC SLLASGTAAL
360 370 380 390 400
ACVFLGVTVD RFGRRGILLL SMTLTGIASL VLLGLWDCEH PIFPTVWAQQ
410 420 430 440 450
GNPNRDLNEA AITTFSVLGL FSSQAAAILS TLLAAEVIPT TVRGRGLGLI
460 470 480 490 500
MALGALGGLS GPAQRLHMGH GAFLQHVVLA ACALLCILSI MLLPETKRKL
510 520 530
LPEVLRDGEL CRRPSLLRQP PPTRCDHVPL LATPNPAL
Length:538
Mass (Da):57,686
Last modified:March 1, 2002 - v1
Checksum:iB332F4ED80BF2387
GO
Isoform 2 (identifier: Q8WUG5-2) [UniParc]FASTAAdd to basket

Also known as: NgalR-2

The sequence of this isoform differs from the canonical sequence as follows:
     388-406: CEHPIFPTVWAQQGNPNRD → Y

Show »
Length:520
Mass (Da):55,658
Checksum:i9DA29182875B4D1D
GO
Isoform 3 (identifier: Q8WUG5-3) [UniParc]FASTAAdd to basket

Also known as: NgalR-3

The sequence of this isoform differs from the canonical sequence as follows:
     176-207: RLELCDPTQRLRVALAGELVGVGGHFLFLGLA → PNDHRSLHPLPVLWLAWFVPGVRTVADSEAAD
     208-538: Missing.

Show »
Length:207
Mass (Da):21,712
Checksum:i3A487F92CF729E86
GO

Sequence cautioni

The sequence CAC01119.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAC17762.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti103 – 1031E → G in ABG45942 (PubMed:17253959).Curated
Sequence conflicti124 – 1241R → G in ABG45942 (PubMed:17253959).Curated
Sequence conflicti293 – 2931F → S in CAC01119 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei176 – 20732RLELC…FLGLA → PNDHRSLHPLPVLWLAWFVP GVRTVADSEAAD in isoform 3. 1 PublicationVSP_039782Add
BLAST
Alternative sequencei208 – 538331Missing in isoform 3. 1 PublicationVSP_039783Add
BLAST
Alternative sequencei388 – 40619CEHPI…NPNRD → Y in isoform 2. 3 PublicationsVSP_003774Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ658848 mRNA. Translation: ABG45942.1.
BX161416 mRNA. Translation: CAD61891.1.
AL049829 Genomic DNA. No translation available.
BC020565 mRNA. Translation: AAH20565.1.
BC090870 mRNA. Translation: AAH90870.1.
BC111015 mRNA. Translation: AAI11016.1.
AJ243122 Genomic DNA. Translation: CAC17762.1. Different initiation.
AJ243653 mRNA. Translation: CAC01119.1. Different initiation.
CCDSiCCDS9593.1. [Q8WUG5-1]
CCDS9594.2. [Q8WUG5-2]
RefSeqiNP_001275979.1. NM_001289050.1.
NP_057693.3. NM_016609.4. [Q8WUG5-2]
NP_065105.2. NM_020372.3. [Q8WUG5-1]
XP_005267804.1. XM_005267747.3. [Q8WUG5-1]
UniGeneiHs.373498.

Genome annotation databases

EnsembliENST00000206544; ENSP00000206544; ENSG00000092096. [Q8WUG5-1]
ENST00000354772; ENSP00000346824; ENSG00000092096. [Q8WUG5-2]
ENST00000397267; ENSP00000380437; ENSG00000092096. [Q8WUG5-1]
GeneIDi51310.
KEGGihsa:51310.
UCSCiuc001wjl.5. human. [Q8WUG5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ658848 mRNA. Translation: ABG45942.1.
BX161416 mRNA. Translation: CAD61891.1.
AL049829 Genomic DNA. No translation available.
BC020565 mRNA. Translation: AAH20565.1.
BC090870 mRNA. Translation: AAH90870.1.
BC111015 mRNA. Translation: AAI11016.1.
AJ243122 Genomic DNA. Translation: CAC17762.1. Different initiation.
AJ243653 mRNA. Translation: CAC01119.1. Different initiation.
CCDSiCCDS9593.1. [Q8WUG5-1]
CCDS9594.2. [Q8WUG5-2]
RefSeqiNP_001275979.1. NM_001289050.1.
NP_057693.3. NM_016609.4. [Q8WUG5-2]
NP_065105.2. NM_020372.3. [Q8WUG5-1]
XP_005267804.1. XM_005267747.3. [Q8WUG5-1]
UniGeneiHs.373498.

3D structure databases

ProteinModelPortaliQ8WUG5.
SMRiQ8WUG5. Positions 97-124.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000206544.

Protein family/group databases

TCDBi2.A.1.19.8. the major facilitator superfamily (mfs).

PTM databases

PhosphoSiteiQ8WUG5.

Polymorphism and mutation databases

DMDMi27805426.

Proteomic databases

PaxDbiQ8WUG5.
PRIDEiQ8WUG5.

Protocols and materials databases

DNASUi51310.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000206544; ENSP00000206544; ENSG00000092096. [Q8WUG5-1]
ENST00000354772; ENSP00000346824; ENSG00000092096. [Q8WUG5-2]
ENST00000397267; ENSP00000380437; ENSG00000092096. [Q8WUG5-1]
GeneIDi51310.
KEGGihsa:51310.
UCSCiuc001wjl.5. human. [Q8WUG5-1]

Organism-specific databases

CTDi51310.
GeneCardsiSLC22A17.
HGNCiHGNC:23095. SLC22A17.
HPAiHPA002728.
MIMi611461. gene.
neXtProtiNX_Q8WUG5.
PharmGKBiPA134879149.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IRI7. Eukaryota.
ENOG411129W. LUCA.
GeneTreeiENSGT00390000014377.
HOVERGENiHBG031124.
InParanoidiQ8WUG5.
KOiK08213.
OMAiTRLELCE.
OrthoDBiEOG7PP56J.
PhylomeDBiQ8WUG5.
TreeFamiTF335753.

Enzyme and pathway databases

ReactomeiR-HSA-917937. Iron uptake and transport.

Miscellaneous databases

ChiTaRSiSLC22A17. human.
GenomeRNAii51310.
NextBioi54641.
PROiQ8WUG5.
SOURCEiSearch...

Gene expression databases

BgeeiQ8WUG5.
CleanExiHS_SLC22A17.
ExpressionAtlasiQ8WUG5. baseline and differential.
GenevisibleiQ8WUG5. HS.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A novel alternative spliced variant of neutrophil gelatinase-associated lipocalin receptor in oesophageal carcinoma cells."
    Fang W.K., Xu L.Y., Lu X.F., Liao L.D., Cai W.J., Shen Z.Y., Li E.M.
    Biochem. J. 403:297-303(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), SUBCELLULAR LOCATION.
  2. "Full-length cDNA libraries and normalization."
    Li W.B., Gruber C., Jessee J., Polayes D.
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Neuroblastoma.
  3. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 72-538 (ISOFORM 2).
    Tissue: Brain.
  5. "Cloning, functional expression and gene structure of a human brain organic cation transporter."
    Bruess M., Hayer M., Boenisch H.
    Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 124-538 (ISOFORM 2).
    Tissue: Brain.
  6. "A cell-surface receptor for lipocalin 24p3 selectively mediates apoptosis and iron uptake."
    Devireddy L.R., Gazin C., Zhu X., Green M.R.
    Cell 123:1293-1305(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
  7. "Transcription and signalling pathways involved in BCR-ABL-mediated misregulation of 24p3 and 24p3R."
    Sheng Z., Wang S.Z., Green M.R.
    EMBO J. 28:866-876(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.

Entry informationi

Entry nameiS22AH_HUMAN
AccessioniPrimary (citable) accession number: Q8WUG5
Secondary accession number(s): A4UA13
, A8MUT0, Q2TAB0, Q5BKY8, Q86U04, Q9H1D3, Q9NQD5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: March 1, 2002
Last modified: March 16, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.