Q8WUF8 (F172A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein FAM172A

Gene names

Name:	FAM172A
Synonyms:	C5orf21

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	416 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Secreted Potential.
Sequence similarities	Belongs to the UPF0528 family.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Signal
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	endoplasmic reticulum Inferred from direct assay. Source: LIFEdb extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8WUF8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8WUF8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     263-416: ENGSPEEHAI...RSHRIKHEEL → VSEITTFLYYFLYLVYILLYVDCFVFLQEY

Note: No experimental confirmation available.

Isoform 3 (identifier: Q8WUF8-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-46: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q8WUF8-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-46: Missing.
     126-189: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 18	18	Potential
	Chain	19 – 416	398	Protein FAM172A		PRO_0000320931
Regions
	Motif	413 – 416	4	Prevents secretion from ER Potential
Natural variations
	Alternative sequence	1 – 46	46	Missing in isoform 3 and isoform 4.		VSP_043313
	Alternative sequence	126 – 189	64	Missing in isoform 4.		VSP_043314
	Alternative sequence	263 – 416	154	ENGSP…KHEEL → VSEITTFLYYFLYLVYILLY VDCFVFLQEY in isoform 2.		VSP_031749
	Natural variant	131	1	S → N. Corresponds to variant rs17083426 [ dbSNP | Ensembl ].		VAR_039312
Experimental info
	Sequence conflict	236	1	E → V in CAB66565. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 37D05325D12FE7ED	FASTA	416	47,972
	10 20 30 40 50 60 MSISLSSLIL LPIWINMAQI QQGGPDEKEK TTALKDLLSR IDLDELMKKD EPPLDFPDTL 70 80 90 100 110 120 EGFEYAFNEK GQLRHIKTGE PFVFNYREDL HRWNQKRYEA LGEIITKYVY ELLEKDCNLK 130 140 150 160 170 180 KVSIPVDATE SEPKSFIFMS EDALTNPQKL MVLIHGSGVV RAGQWARRLI INEDLDSGTQ 190 200 210 220 230 240 IPFIKRAVAE GYGVIVLNPN ENYIEVEKPK IHVQSSSDSS DEPAEKRERK DKVSKETKKR 250 260 270 280 290 300 RDFYEKYRNP QREKEMMQLY IRENGSPEEH AIYVWDHFIA QAAAENVFFV AHSYGGLAFV 310 320 330 340 350 360 ELMIQREADV KNKVTAVALT DSVHNVWHQE AGKTIREWMR ENCCNWVSSS EPLDTSVESM 370 380 390 400 410 LPDCPRVSAG TDRHELTSWK SFPSIFKFFT EASEAKTSSL KPAVTRRSHR IKHEEL
	Isoform 2 [UniParc]. Checksum: 4EE1DB236A41AA54	FASTA	292	34,290
	10 20 30 40 50 60 MSISLSSLIL LPIWINMAQI QQGGPDEKEK TTALKDLLSR IDLDELMKKD EPPLDFPDTL 70 80 90 100 110 120 EGFEYAFNEK GQLRHIKTGE PFVFNYREDL HRWNQKRYEA LGEIITKYVY ELLEKDCNLK 130 140 150 160 170 180 KVSIPVDATE SEPKSFIFMS EDALTNPQKL MVLIHGSGVV RAGQWARRLI INEDLDSGTQ 190 200 210 220 230 240 IPFIKRAVAE GYGVIVLNPN ENYIEVEKPK IHVQSSSDSS DEPAEKRERK DKVSKETKKR 250 260 270 280 290 RDFYEKYRNP QREKEMMQLY IRVSEITTFL YYFLYLVYIL LYVDCFVFLQ EY
	Isoform 3 [UniParc]. Checksum: 7D958B1DC1AFE20C	FASTA	370	42,851
	10 20 30 40 50 60 MKKDEPPLDF PDTLEGFEYA FNEKGQLRHI KTGEPFVFNY REDLHRWNQK RYEALGEIIT 70 80 90 100 110 120 KYVYELLEKD CNLKKVSIPV DATESEPKSF IFMSEDALTN PQKLMVLIHG SGVVRAGQWA 130 140 150 160 170 180 RRLIINEDLD SGTQIPFIKR AVAEGYGVIV LNPNENYIEV EKPKIHVQSS SDSSDEPAEK 190 200 210 220 230 240 RERKDKVSKE TKKRRDFYEK YRNPQREKEM MQLYIRENGS PEEHAIYVWD HFIAQAAAEN 250 260 270 280 290 300 VFFVAHSYGG LAFVELMIQR EADVKNKVTA VALTDSVHNV WHQEAGKTIR EWMRENCCNW 310 320 330 340 350 360 VSSSEPLDTS VESMLPDCPR VSAGTDRHEL TSWKSFPSIF KFFTEASEAK TSSLKPAVTR 370 RSHRIKHEEL
	Isoform 4 [UniParc]. Checksum: 085812F213DC7C45	FASTA	306	35,800
	10 20 30 40 50 60 MKKDEPPLDF PDTLEGFEYA FNEKGQLRHI KTGEPFVFNY REDLHRWNQK RYEALGEIIT 70 80 90 100 110 120 KYVYELLEKD CNLKKVSIPE GYGVIVLNPN ENYIEVEKPK IHVQSSSDSS DEPAEKRERK 130 140 150 160 170 180 DKVSKETKKR RDFYEKYRNP QREKEMMQLY IRENGSPEEH AIYVWDHFIA QAAAENVFFV 190 200 210 220 230 240 AHSYGGLAFV ELMIQREADV KNKVTAVALT DSVHNVWHQE AGKTIREWMR ENCCNWVSSS 250 260 270 280 290 300 EPLDTSVESM LPDCPRVSAG TDRHELTSWK SFPSIFKFFT EASEAKTSSL KPAVTRRSHR IKHEEL

References

[1]	"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A. Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4). Tissue: Hippocampus, Placenta and Tongue.
[3]	"The DNA sequence and comparative analysis of human chromosome 5." Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M. Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Duodenum.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL136630 mRNA. Translation: CAB66565.1. AK295879 mRNA. Translation: BAG58676.1. AK296986 mRNA. Translation: BAG59527.1. AK312930 mRNA. Translation: BAG35773.1. AC093268 Genomic DNA. No translation available. AC099501 Genomic DNA. No translation available. AC106818 Genomic DNA. No translation available. AC108102 Genomic DNA. No translation available. AC114980 Genomic DNA. No translation available. AC117528 Genomic DNA. No translation available. CH471084 Genomic DNA. Translation: EAW96012.1. BC020584 mRNA. Translation: AAH20584.1.
IPI	IPI00102909. IPI00885201. IPI00908481.
RefSeq	NP_001156889.1. NM_001163417.1. NP_001156890.1. NM_001163418.1. NP_114431.2. NM_032042.5.
UniGene	Hs.600086.
3D structure databases
ProteinModelPortal	Q8WUF8.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8WUF8. 1 interaction.
PTM databases
PhosphoSite	Q8WUF8.
Polymorphism databases
DMDM	74730707.
Proteomic databases
PaxDb	Q8WUF8.
PRIDE	Q8WUF8.
Protocols and materials databases
DNASU	83989.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000395965; ENSP00000379294; ENSG00000113391. ENST00000505869; ENSP00000426284; ENSG00000113391. ENST00000509163; ENSP00000423841; ENSG00000113391.
GeneID	83989.
KEGG	hsa:83989.
UCSC	uc003kkm.4. human. uc010jbd.3. human.
Organism-specific databases
CTD	83989.
GeneCards	GC05M092981.
HGNC	HGNC:25365. FAM172A.
HPA	HPA012299.
neXtProt	NX_Q8WUF8.
PharmGKB	PA162387241.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG263064.
HOGENOM	HOG000046503.
HOVERGEN	HBG107877.
InParanoid	Q8WUF8.
OMA	AVTRRSH.
OrthoDB	EOG4ZS936.
Gene expression databases
ArrayExpress	Q8WUF8.
Bgee	Q8WUF8.
CleanEx	HS_FAM172A.
Genevestigator	Q8WUF8.
Family and domain databases
InterPro	IPR019154. Arb2_domain. [Graphical view]
Pfam	PF09757. Arb2. 1 hit. [Graphical view]
PROSITE	PS00014. ER_TARGET. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	FAM172A. human.
GenomeRNAi	83989.
NextBio	73144.

Entry information

Entry name

F172A_HUMAN

Accession

Primary (citable) accession number: Q8WUF8
Secondary accession number(s): B2R7C6 , B4DJ14, B4DLG5, Q9H0U8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	March 1, 2002
Last modified:	May 1, 2013
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.