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Q8WUF8 (F172A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein FAM172A
Gene names
Name:FAM172A
Synonyms:C5orf21
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length416 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Secreted Potential.

Sequence similarities

Belongs to the UPF0528 family.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainSignal
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentendoplasmic reticulum

Inferred from direct assay. Source: LIFEdb

extracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8WUF8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8WUF8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     263-416: ENGSPEEHAI...RSHRIKHEEL → VSEITTFLYYFLYLVYILLYVDCFVFLQEY
Note: No experimental confirmation available.
Isoform 3 (identifier: Q8WUF8-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-46: Missing.
Note: No experimental confirmation available.
Isoform 4 (identifier: Q8WUF8-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-46: Missing.
     126-189: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Chain19 – 416398Protein FAM172A
PRO_0000320931

Regions

Motif413 – 4164Prevents secretion from ER Potential

Natural variations

Alternative sequence1 – 4646Missing in isoform 3 and isoform 4.
VSP_043313
Alternative sequence126 – 18964Missing in isoform 4.
VSP_043314
Alternative sequence263 – 416154ENGSP…KHEEL → VSEITTFLYYFLYLVYILLY VDCFVFLQEY in isoform 2.
VSP_031749
Natural variant1311S → N.
Corresponds to variant rs17083426 [ dbSNP | Ensembl ].
VAR_039312

Experimental info

Sequence conflict2361E → V in CAB66565. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 37D05325D12FE7ED

FASTA41647,972
        10         20         30         40         50         60 
MSISLSSLIL LPIWINMAQI QQGGPDEKEK TTALKDLLSR IDLDELMKKD EPPLDFPDTL 

        70         80         90        100        110        120 
EGFEYAFNEK GQLRHIKTGE PFVFNYREDL HRWNQKRYEA LGEIITKYVY ELLEKDCNLK 

       130        140        150        160        170        180 
KVSIPVDATE SEPKSFIFMS EDALTNPQKL MVLIHGSGVV RAGQWARRLI INEDLDSGTQ 

       190        200        210        220        230        240 
IPFIKRAVAE GYGVIVLNPN ENYIEVEKPK IHVQSSSDSS DEPAEKRERK DKVSKETKKR 

       250        260        270        280        290        300 
RDFYEKYRNP QREKEMMQLY IRENGSPEEH AIYVWDHFIA QAAAENVFFV AHSYGGLAFV 

       310        320        330        340        350        360 
ELMIQREADV KNKVTAVALT DSVHNVWHQE AGKTIREWMR ENCCNWVSSS EPLDTSVESM 

       370        380        390        400        410 
LPDCPRVSAG TDRHELTSWK SFPSIFKFFT EASEAKTSSL KPAVTRRSHR IKHEEL 

« Hide

Isoform 2 [UniParc].

Checksum: 4EE1DB236A41AA54
Show »

FASTA29234,290
Isoform 3 [UniParc].

Checksum: 7D958B1DC1AFE20C
Show »

FASTA37042,851
Isoform 4 [UniParc].

Checksum: 085812F213DC7C45
Show »

FASTA30635,800

References

[1]"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."
Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S., Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W., Ottenwaelder B., Obermaier B. expand/collapse author list , Tampe J., Heubner D., Wambutt R., Korn B., Klein M., Poustka A.
Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Brain.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4).
Tissue: Hippocampus, Placenta and Tongue.
[3]"The DNA sequence and comparative analysis of human chromosome 5."
Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. expand/collapse author list , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Duodenum.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL136630 mRNA. Translation: CAB66565.1.
AK295879 mRNA. Translation: BAG58676.1.
AK296986 mRNA. Translation: BAG59527.1.
AK312930 mRNA. Translation: BAG35773.1.
AC093268 Genomic DNA. No translation available.
AC099501 Genomic DNA. No translation available.
AC106818 Genomic DNA. No translation available.
AC108102 Genomic DNA. No translation available.
AC114980 Genomic DNA. No translation available.
AC117528 Genomic DNA. No translation available.
CH471084 Genomic DNA. Translation: EAW96012.1.
BC020584 mRNA. Translation: AAH20584.1.
CCDSCCDS4069.1. [Q8WUF8-1]
CCDS54879.1. [Q8WUF8-4]
CCDS54880.1. [Q8WUF8-3]
RefSeqNP_001156889.1. NM_001163417.1. [Q8WUF8-3]
NP_001156890.1. NM_001163418.1. [Q8WUF8-4]
NP_114431.2. NM_032042.5. [Q8WUF8-1]
XP_005272161.1. XM_005272104.2. [Q8WUF8-3]
XP_006714780.1. XM_006714717.1. [Q8WUF8-1]
UniGeneHs.600086.

3D structure databases

ProteinModelPortalQ8WUF8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid123840. 3 interactions.
IntActQ8WUF8. 1 interaction.
MINTMINT-4722953.

PTM databases

PhosphoSiteQ8WUF8.

Polymorphism databases

DMDM74730707.

Proteomic databases

MaxQBQ8WUF8.
PaxDbQ8WUF8.
PRIDEQ8WUF8.

Protocols and materials databases

DNASU83989.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000395965; ENSP00000379294; ENSG00000113391. [Q8WUF8-1]
ENST00000505869; ENSP00000426284; ENSG00000113391. [Q8WUF8-4]
ENST00000509163; ENSP00000423841; ENSG00000113391. [Q8WUF8-3]
GeneID83989.
KEGGhsa:83989.
UCSCuc003kkm.4. human. [Q8WUF8-2]
uc010jbd.3. human. [Q8WUF8-1]
uc011cug.2. human. [Q8WUF8-4]

Organism-specific databases

CTD83989.
GeneCardsGC05M092981.
HGNCHGNC:25365. FAM172A.
HPAHPA012299.
HPA045505.
neXtProtNX_Q8WUF8.
PharmGKBPA162387241.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG263064.
HOGENOMHOG000046503.
HOVERGENHBG107877.
InParanoidQ8WUF8.
OMAEEHVLYV.
OrthoDBEOG71K64J.
PhylomeDBQ8WUF8.
TreeFamTF315960.

Gene expression databases

ArrayExpressQ8WUF8.
BgeeQ8WUF8.
CleanExHS_FAM172A.
GenevestigatorQ8WUF8.

Family and domain databases

Gene3D3.40.50.1820. 2 hits.
InterProIPR029058. AB_hydrolase.
IPR019154. Arb2_domain.
[Graphical view]
PfamPF09757. Arb2. 1 hit.
[Graphical view]
SUPFAMSSF53474. SSF53474. 2 hits.
PROSITEPS00014. ER_TARGET. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSFAM172A. human.
GeneWikiC5orf21.
GenomeRNAi83989.
NextBio73144.
PROQ8WUF8.

Entry information

Entry nameF172A_HUMAN
AccessionPrimary (citable) accession number: Q8WUF8
Secondary accession number(s): B2R7C6 expand/collapse secondary AC list , B4DJ14, B4DLG5, Q9H0U8
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: March 1, 2002
Last modified: July 9, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Uncharacterized protein families (UPF)

List of uncharacterized protein family (UPF) entries

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM