Q8WUD4 (CCD12_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Coiled-coil domain-containing protein 12

Gene names

Name:

CCDC12

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	166 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Ontologies

Keywords
Domain	Coiled coil
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 166	166	Coiled-coil domain-containing protein 12		PRO_0000076191
Regions
	Coiled coil	8 – 28	21	Potential
	Coiled coil	117 – 144	28	Potential
Amino acid modifications
	Modified residue	165	1	Phosphoserine Ref.3
Experimental info
	Sequence conflict	97	1	P → S in BAC04857. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q8WUD4 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 8222968EF263F0AD	FASTA	166	19,181
	10 20 30 40 50 60 MEATTAGVGR LEEEALRRKE RLKALREKTG RKDKEDGEPK TKHLREEEEE GEKHRELRLR 70 80 90 100 110 120 NYVPEDEDLK KRRVPQAKPV AVEEKVKEQL EAAKPEPVIE EVDLANLAPR KPDWDLKRDV 130 140 150 160 AKKLEKLKKR TQRAIAELIR ERLKGQEDSL ASAVDAATEQ KTCDSD

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Prostate.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[3]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-165, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[4]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK096749 mRNA. Translation: BAC04857.1. BC020830 mRNA. Translation: AAH20830.1.
IPI	IPI01012992.
RefSeq	NP_001264003.1. NM_001277074.1.
UniGene	Hs.692157. Hs.740620.
3D structure databases
ProteinModelPortal	Q8WUD4.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8WUD4. 4 interactions.
STRING	9606.ENSP00000292314.
PTM databases
PhosphoSite	Q8WUD4.
Polymorphism databases
DMDM	74730697.
Proteomic databases
PaxDb	Q8WUD4.
PeptideAtlas	Q8WUD4.
PRIDE	Q8WUD4.
Protocols and materials databases
DNASU	151903.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000546280; ENSP00000441327; ENSG00000160799.
GeneID	151903.
KEGG	hsa:151903.
UCSC	uc003cqo.2. human.
Organism-specific databases
CTD	151903.
GeneCards	GC03M046939.
H-InvDB	HIX0003254.
HGNC	HGNC:28332. CCDC12.
HPA	HPA056814.
neXtProt	NX_Q8WUD4.
PharmGKB	PA134970849.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG146899.
HOGENOM	HOG000005890.
HOVERGEN	HBG059850.
InParanoid	Q8WUD4.
KO	K12871.
OrthoDB	EOG4PNXJD.
PhylomeDB	Q8WUD4.
Gene expression databases
ArrayExpress	Q8WUD4.
Bgee	Q8WUD4.
CleanEx	HS_CCDC12.
Genevestigator	Q8WUD4.
GermOnline	ENSG00000160799. Homo sapiens.
Family and domain databases
InterPro	IPR013169. mRNA_splic_Cwf18. [Graphical view]
Pfam	PF08315. cwf18. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	CCDC12. human.
GenomeRNAi	151903.
NextBio	86823.

Entry information

Entry name

CCD12_HUMAN

Accession

Primary (citable) accession number: Q8WUD4
Secondary accession number(s): Q8N8I4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 24, 2006
Last sequence update:	March 1, 2002
Last modified:	May 1, 2013
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.