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Protein

Coiled-coil domain-containing protein 12

Gene

CCDC12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 12
Gene namesi
Name:CCDC12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:28332. CCDC12.

Subcellular locationi

GO - Cellular componenti

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000160799.
PharmGKBiPA134970849.

Polymorphism and mutation databases

DMDMi74730697.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000761911 – 166Coiled-coil domain-containing protein 12Add BLAST166

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei53N6-acetyllysineBy similarity1
Cross-linki94Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei149PhosphoserineCombined sources1
Modified residuei165PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8WUD4.
MaxQBiQ8WUD4.
PaxDbiQ8WUD4.
PeptideAtlasiQ8WUD4.
PRIDEiQ8WUD4.

PTM databases

iPTMnetiQ8WUD4.
PhosphoSitePlusiQ8WUD4.

Expressioni

Gene expression databases

BgeeiENSG00000160799.
CleanExiHS_CCDC12.
ExpressionAtlasiQ8WUD4. baseline and differential.
GenevisibleiQ8WUD4. HS.

Organism-specific databases

HPAiHPA056814.
HPA060530.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CRNKL1Q9BZJ02EBI-2557572,EBI-1049701

Protein-protein interaction databases

BioGridi127412. 52 interactors.
IntActiQ8WUD4. 8 interactors.
MINTiMINT-2812448.
STRINGi9606.ENSP00000292314.

Structurei

3D structure databases

ProteinModelPortaliQ8WUD4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili8 – 28Sequence analysisAdd BLAST21
Coiled coili117 – 144Sequence analysisAdd BLAST28

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3407. Eukaryota.
ENOG4111R31. LUCA.
GeneTreeiENSGT00390000011619.
HOGENOMiHOG000005890.
HOVERGENiHBG059850.
InParanoidiQ8WUD4.
KOiK12871.
PhylomeDBiQ8WUD4.

Family and domain databases

Gene3Di3.30.1360.70. 1 hit.
InterProiView protein in InterPro
IPR005148. Arg-tRNA-synth_N.
IPR013169. mRNA_splic_Cwf18.
PfamiView protein in Pfam
PF08315. cwf18. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8WUD4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEATTAGVGR LEEEALRRKE RLKALREKTG RKDKEDGEPK TKHLREEEEE
60 70 80 90 100
GEKHRELRLR NYVPEDEDLK KRRVPQAKPV AVEEKVKEQL EAAKPEPVIE
110 120 130 140 150
EVDLANLAPR KPDWDLKRDV AKKLEKLKKR TQRAIAELIR ERLKGQEDSL
160
ASAVDAATEQ KTCDSD
Length:166
Mass (Da):19,181
Last modified:March 1, 2002 - v1
Checksum:i8222968EF263F0AD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti97P → S in BAC04857 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096749 mRNA. Translation: BAC04857.1.
BC020830 mRNA. Translation: AAH20830.1.
CCDSiCCDS2748.3.
RefSeqiNP_001264003.1. NM_001277074.1.
UniGeneiHs.631918.
Hs.692157.
Hs.745081.

Genome annotation databases

EnsembliENST00000425441; ENSP00000416263; ENSG00000160799.
GeneIDi151903.
KEGGihsa:151903.
UCSCiuc062jbe.1. human.

Similar proteinsi

Entry informationi

Entry nameiCCD12_HUMAN
AccessioniPrimary (citable) accession number: Q8WUD4
Secondary accession number(s): Q8N8I4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: March 1, 2002
Last modified: August 30, 2017
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM