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Protein

Coiled-coil domain-containing protein 12

Gene

CCDC12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 12
Gene namesi
Name:CCDC12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000160799.11
HGNCiHGNC:28332 CCDC12
neXtProtiNX_Q8WUD4

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000160799
PharmGKBiPA134970849

Polymorphism and mutation databases

DMDMi74730697

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000761911 – 166Coiled-coil domain-containing protein 12Add BLAST166

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei53N6-acetyllysineBy similarity1
Cross-linki94Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei149PhosphoserineCombined sources1
Modified residuei165PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ8WUD4
MaxQBiQ8WUD4
PaxDbiQ8WUD4
PeptideAtlasiQ8WUD4
PRIDEiQ8WUD4

PTM databases

iPTMnetiQ8WUD4
PhosphoSitePlusiQ8WUD4

Expressioni

Gene expression databases

BgeeiENSG00000160799
CleanExiHS_CCDC12
ExpressionAtlasiQ8WUD4 baseline and differential
GenevisibleiQ8WUD4 HS

Organism-specific databases

HPAiHPA056814
HPA060530

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CRNKL1Q9BZJ02EBI-2557572,EBI-1049701

Protein-protein interaction databases

BioGridi12741252 interactors.
IntActiQ8WUD4 8 interactors.
MINTiQ8WUD4
STRINGi9606.ENSP00000292314

Structurei

3D structure databases

ProteinModelPortaliQ8WUD4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili8 – 28Sequence analysisAdd BLAST21
Coiled coili117 – 144Sequence analysisAdd BLAST28

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3407 Eukaryota
ENOG4111R31 LUCA
GeneTreeiENSGT00390000011619
HOGENOMiHOG000005890
HOVERGENiHBG059850
InParanoidiQ8WUD4
KOiK12871
PhylomeDBiQ8WUD4

Family and domain databases

InterProiView protein in InterPro
IPR013169 mRNA_splic_Cwf18
PANTHERiPTHR31551 PTHR31551, 1 hit
PfamiView protein in Pfam
PF08315 cwf18, 1 hit

Sequencei

Sequence statusi: Complete.

Q8WUD4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEATTAGVGR LEEEALRRKE RLKALREKTG RKDKEDGEPK TKHLREEEEE
60 70 80 90 100
GEKHRELRLR NYVPEDEDLK KRRVPQAKPV AVEEKVKEQL EAAKPEPVIE
110 120 130 140 150
EVDLANLAPR KPDWDLKRDV AKKLEKLKKR TQRAIAELIR ERLKGQEDSL
160
ASAVDAATEQ KTCDSD
Length:166
Mass (Da):19,181
Last modified:March 1, 2002 - v1
Checksum:i8222968EF263F0AD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti97P → S in BAC04857 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096749 mRNA Translation: BAC04857.1
BC020830 mRNA Translation: AAH20830.1
CCDSiCCDS2748.3
RefSeqiNP_001264003.1, NM_001277074.1
UniGeneiHs.631918
Hs.692157
Hs.745081

Genome annotation databases

EnsembliENST00000425441; ENSP00000416263; ENSG00000160799
GeneIDi151903
KEGGihsa:151903
UCSCiuc062jbe.1 human

Similar proteinsi

Entry informationi

Entry nameiCCD12_HUMAN
AccessioniPrimary (citable) accession number: Q8WUD4
Secondary accession number(s): Q8N8I4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: March 1, 2002
Last modified: March 28, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome