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Q8WUD4

- CCD12_HUMAN

UniProt

Q8WUD4 - CCD12_HUMAN

Protein

Coiled-coil domain-containing protein 12

Gene

CCDC12

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. protein binding Source: IntAct

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Coiled-coil domain-containing protein 12
    Gene namesi
    Name:CCDC12
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:28332. CCDC12.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134970849.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 166166Coiled-coil domain-containing protein 12PRO_0000076191Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine2 Publications
    Modified residuei53 – 531N6-acetyllysineBy similarity
    Modified residuei165 – 1651Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ8WUD4.
    PaxDbiQ8WUD4.
    PeptideAtlasiQ8WUD4.
    PRIDEiQ8WUD4.

    PTM databases

    PhosphoSiteiQ8WUD4.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8WUD4.
    BgeeiQ8WUD4.
    CleanExiHS_CCDC12.
    GenevestigatoriQ8WUD4.

    Organism-specific databases

    HPAiHPA049307.
    HPA056814.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CRNKL1Q9BZJ02EBI-2557572,EBI-1049701

    Protein-protein interaction databases

    BioGridi127412. 7 interactions.
    IntActiQ8WUD4. 5 interactions.
    MINTiMINT-2812448.
    STRINGi9606.ENSP00000292314.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8WUD4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili8 – 2821Sequence AnalysisAdd
    BLAST
    Coiled coili117 – 14428Sequence AnalysisAdd
    BLAST

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG146899.
    HOGENOMiHOG000005890.
    HOVERGENiHBG059850.
    InParanoidiQ8WUD4.
    KOiK12871.
    OrthoDBiEOG7P8P9B.
    PhylomeDBiQ8WUD4.

    Family and domain databases

    InterProiIPR013169. mRNA_splic_Cwf18.
    [Graphical view]
    PfamiPF08315. cwf18. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8WUD4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEATTAGVGR LEEEALRRKE RLKALREKTG RKDKEDGEPK TKHLREEEEE    50
    GEKHRELRLR NYVPEDEDLK KRRVPQAKPV AVEEKVKEQL EAAKPEPVIE 100
    EVDLANLAPR KPDWDLKRDV AKKLEKLKKR TQRAIAELIR ERLKGQEDSL 150
    ASAVDAATEQ KTCDSD 166
    Length:166
    Mass (Da):19,181
    Last modified:March 1, 2002 - v1
    Checksum:i8222968EF263F0AD
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti97 – 971P → S in BAC04857. (PubMed:14702039)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK096749 mRNA. Translation: BAC04857.1.
    BC020830 mRNA. Translation: AAH20830.1.
    CCDSiCCDS2748.3.
    RefSeqiNP_001264003.1. NM_001277074.1.
    UniGeneiHs.631918.
    Hs.692157.
    Hs.745081.

    Genome annotation databases

    EnsembliENST00000546280; ENSP00000441327; ENSG00000160799.
    GeneIDi151903.
    KEGGihsa:151903.

    Polymorphism databases

    DMDMi74730697.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK096749 mRNA. Translation: BAC04857.1 .
    BC020830 mRNA. Translation: AAH20830.1 .
    CCDSi CCDS2748.3.
    RefSeqi NP_001264003.1. NM_001277074.1.
    UniGenei Hs.631918.
    Hs.692157.
    Hs.745081.

    3D structure databases

    ProteinModelPortali Q8WUD4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 127412. 7 interactions.
    IntActi Q8WUD4. 5 interactions.
    MINTi MINT-2812448.
    STRINGi 9606.ENSP00000292314.

    PTM databases

    PhosphoSitei Q8WUD4.

    Polymorphism databases

    DMDMi 74730697.

    Proteomic databases

    MaxQBi Q8WUD4.
    PaxDbi Q8WUD4.
    PeptideAtlasi Q8WUD4.
    PRIDEi Q8WUD4.

    Protocols and materials databases

    DNASUi 151903.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000546280 ; ENSP00000441327 ; ENSG00000160799 .
    GeneIDi 151903.
    KEGGi hsa:151903.

    Organism-specific databases

    CTDi 151903.
    GeneCardsi GC03M046939.
    H-InvDB HIX0003254.
    HGNCi HGNC:28332. CCDC12.
    HPAi HPA049307.
    HPA056814.
    neXtProti NX_Q8WUD4.
    PharmGKBi PA134970849.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG146899.
    HOGENOMi HOG000005890.
    HOVERGENi HBG059850.
    InParanoidi Q8WUD4.
    KOi K12871.
    OrthoDBi EOG7P8P9B.
    PhylomeDBi Q8WUD4.

    Miscellaneous databases

    ChiTaRSi CCDC12. human.
    GenomeRNAii 151903.
    NextBioi 86823.
    PROi Q8WUD4.

    Gene expression databases

    ArrayExpressi Q8WUD4.
    Bgeei Q8WUD4.
    CleanExi HS_CCDC12.
    Genevestigatori Q8WUD4.

    Family and domain databases

    InterProi IPR013169. mRNA_splic_Cwf18.
    [Graphical view ]
    Pfami PF08315. cwf18. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Prostate.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-165, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    4. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    6. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCCD12_HUMAN
    AccessioniPrimary (citable) accession number: Q8WUD4
    Secondary accession number(s): Q8N8I4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2006
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM

    External Data

    Dasty 3