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Protein

Coiled-coil domain-containing protein 12

Gene

CCDC12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 12
Gene namesi
Name:CCDC12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:28332. CCDC12.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134970849.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 166166Coiled-coil domain-containing protein 12PRO_0000076191Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine2 Publications
Modified residuei53 – 531N6-acetyllysineBy similarity
Modified residuei165 – 1651Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ8WUD4.
PaxDbiQ8WUD4.
PeptideAtlasiQ8WUD4.
PRIDEiQ8WUD4.

PTM databases

PhosphoSiteiQ8WUD4.

Expressioni

Gene expression databases

BgeeiQ8WUD4.
CleanExiHS_CCDC12.
ExpressionAtlasiQ8WUD4. baseline and differential.
GenevestigatoriQ8WUD4.

Organism-specific databases

HPAiHPA056814.
HPA060530.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CRNKL1Q9BZJ02EBI-2557572,EBI-1049701

Protein-protein interaction databases

BioGridi127412. 21 interactions.
IntActiQ8WUD4. 5 interactions.
MINTiMINT-2812448.
STRINGi9606.ENSP00000292314.

Structurei

3D structure databases

ProteinModelPortaliQ8WUD4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili8 – 2821Sequence AnalysisAdd
BLAST
Coiled coili117 – 14428Sequence AnalysisAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG146899.
GeneTreeiENSGT00390000011619.
HOGENOMiHOG000005890.
HOVERGENiHBG059850.
InParanoidiQ8WUD4.
KOiK12871.
OrthoDBiEOG7P8P9B.
PhylomeDBiQ8WUD4.

Family and domain databases

InterProiIPR013169. mRNA_splic_Cwf18.
[Graphical view]
PfamiPF08315. cwf18. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WUD4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEATTAGVGR LEEEALRRKE RLKALREKTG RKDKEDGEPK TKHLREEEEE
60 70 80 90 100
GEKHRELRLR NYVPEDEDLK KRRVPQAKPV AVEEKVKEQL EAAKPEPVIE
110 120 130 140 150
EVDLANLAPR KPDWDLKRDV AKKLEKLKKR TQRAIAELIR ERLKGQEDSL
160
ASAVDAATEQ KTCDSD
Length:166
Mass (Da):19,181
Last modified:March 1, 2002 - v1
Checksum:i8222968EF263F0AD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti97 – 971P → S in BAC04857 (PubMed:14702039).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096749 mRNA. Translation: BAC04857.1.
BC020830 mRNA. Translation: AAH20830.1.
CCDSiCCDS2748.3.
RefSeqiNP_001264003.1. NM_001277074.1.
UniGeneiHs.631918.
Hs.692157.
Hs.745081.

Genome annotation databases

EnsembliENST00000425441; ENSP00000416263; ENSG00000160799.
GeneIDi151903.
KEGGihsa:151903.

Polymorphism databases

DMDMi74730697.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096749 mRNA. Translation: BAC04857.1.
BC020830 mRNA. Translation: AAH20830.1.
CCDSiCCDS2748.3.
RefSeqiNP_001264003.1. NM_001277074.1.
UniGeneiHs.631918.
Hs.692157.
Hs.745081.

3D structure databases

ProteinModelPortaliQ8WUD4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127412. 21 interactions.
IntActiQ8WUD4. 5 interactions.
MINTiMINT-2812448.
STRINGi9606.ENSP00000292314.

PTM databases

PhosphoSiteiQ8WUD4.

Polymorphism databases

DMDMi74730697.

Proteomic databases

MaxQBiQ8WUD4.
PaxDbiQ8WUD4.
PeptideAtlasiQ8WUD4.
PRIDEiQ8WUD4.

Protocols and materials databases

DNASUi151903.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000425441; ENSP00000416263; ENSG00000160799.
GeneIDi151903.
KEGGihsa:151903.

Organism-specific databases

CTDi151903.
GeneCardsiGC03M046939.
H-InvDBHIX0003254.
HGNCiHGNC:28332. CCDC12.
HPAiHPA056814.
HPA060530.
neXtProtiNX_Q8WUD4.
PharmGKBiPA134970849.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG146899.
GeneTreeiENSGT00390000011619.
HOGENOMiHOG000005890.
HOVERGENiHBG059850.
InParanoidiQ8WUD4.
KOiK12871.
OrthoDBiEOG7P8P9B.
PhylomeDBiQ8WUD4.

Miscellaneous databases

ChiTaRSiCCDC12. human.
GenomeRNAii151903.
NextBioi86823.
PROiQ8WUD4.

Gene expression databases

BgeeiQ8WUD4.
CleanExiHS_CCDC12.
ExpressionAtlasiQ8WUD4. baseline and differential.
GenevestigatoriQ8WUD4.

Family and domain databases

InterProiIPR013169. mRNA_splic_Cwf18.
[Graphical view]
PfamiPF08315. cwf18. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-165, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  4. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiCCD12_HUMAN
AccessioniPrimary (citable) accession number: Q8WUD4
Secondary accession number(s): Q8N8I4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: March 1, 2002
Last modified: March 4, 2015
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.