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Q8WUD4 (CCD12_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Coiled-coil domain-containing protein 12
Gene names
Name:CCDC12
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length166 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

Ontologies

Keywords
   DomainCoiled coil
   PTMAcetylation
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionprotein binding

Inferred from physical interaction PubMed 22365833. Source: IntAct

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

CRNKL1Q9BZJ02EBI-2557572,EBI-1049701

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 166166Coiled-coil domain-containing protein 12
PRO_0000076191

Regions

Coiled coil8 – 2821 Potential
Coiled coil117 – 14428 Potential

Amino acid modifications

Modified residue11N-acetylmethionine Ref.4 Ref.6
Modified residue531N6-acetyllysine By similarity
Modified residue1651Phosphoserine Ref.3

Experimental info

Sequence conflict971P → S in BAC04857. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q8WUD4 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 8222968EF263F0AD

FASTA16619,181
        10         20         30         40         50         60 
MEATTAGVGR LEEEALRRKE RLKALREKTG RKDKEDGEPK TKHLREEEEE GEKHRELRLR 

        70         80         90        100        110        120 
NYVPEDEDLK KRRVPQAKPV AVEEKVKEQL EAAKPEPVIE EVDLANLAPR KPDWDLKRDV 

       130        140        150        160 
AKKLEKLKKR TQRAIAELIR ERLKGQEDSL ASAVDAATEQ KTCDSD 

« Hide

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Prostate.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[3]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-165, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[4]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[5]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[6]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK096749 mRNA. Translation: BAC04857.1.
BC020830 mRNA. Translation: AAH20830.1.
CCDSCCDS2748.3.
RefSeqNP_001264003.1. NM_001277074.1.
UniGeneHs.631918.
Hs.692157.
Hs.745081.

3D structure databases

ProteinModelPortalQ8WUD4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid127412. 7 interactions.
IntActQ8WUD4. 5 interactions.
MINTMINT-2812448.
STRING9606.ENSP00000292314.

PTM databases

PhosphoSiteQ8WUD4.

Polymorphism databases

DMDM74730697.

Proteomic databases

MaxQBQ8WUD4.
PaxDbQ8WUD4.
PeptideAtlasQ8WUD4.
PRIDEQ8WUD4.

Protocols and materials databases

DNASU151903.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000546280; ENSP00000441327; ENSG00000160799.
GeneID151903.
KEGGhsa:151903.

Organism-specific databases

CTD151903.
GeneCardsGC03M046939.
H-InvDBHIX0003254.
HGNCHGNC:28332. CCDC12.
HPAHPA049307.
HPA056814.
neXtProtNX_Q8WUD4.
PharmGKBPA134970849.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG146899.
HOGENOMHOG000005890.
HOVERGENHBG059850.
InParanoidQ8WUD4.
KOK12871.
OrthoDBEOG7P8P9B.
PhylomeDBQ8WUD4.

Gene expression databases

ArrayExpressQ8WUD4.
BgeeQ8WUD4.
CleanExHS_CCDC12.
GenevestigatorQ8WUD4.

Family and domain databases

InterProIPR013169. mRNA_splic_Cwf18.
[Graphical view]
PfamPF08315. cwf18. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCCDC12. human.
GenomeRNAi151903.
NextBio86823.
PROQ8WUD4.

Entry information

Entry nameCCD12_HUMAN
AccessionPrimary (citable) accession number: Q8WUD4
Secondary accession number(s): Q8N8I4
Entry history
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: March 1, 2002
Last modified: July 9, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM