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Protein

Coiled-coil domain-containing protein 12

Gene

CCDC12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:ENSG00000160799-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 12
Gene namesi
Name:CCDC12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:28332. CCDC12.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000160799.
PharmGKBiPA134970849.

Polymorphism and mutation databases

DMDMi74730697.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000761911 – 166Coiled-coil domain-containing protein 12Add BLAST166

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei53N6-acetyllysineBy similarity1
Modified residuei149PhosphoserineCombined sources1
Modified residuei165PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ8WUD4.
MaxQBiQ8WUD4.
PaxDbiQ8WUD4.
PeptideAtlasiQ8WUD4.
PRIDEiQ8WUD4.

PTM databases

iPTMnetiQ8WUD4.
PhosphoSitePlusiQ8WUD4.

Expressioni

Gene expression databases

BgeeiENSG00000160799.
CleanExiHS_CCDC12.
ExpressionAtlasiQ8WUD4. baseline and differential.
GenevisibleiQ8WUD4. HS.

Organism-specific databases

HPAiHPA056814.
HPA060530.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CRNKL1Q9BZJ02EBI-2557572,EBI-1049701

Protein-protein interaction databases

BioGridi127412. 35 interactors.
IntActiQ8WUD4. 8 interactors.
MINTiMINT-2812448.
STRINGi9606.ENSP00000292314.

Structurei

3D structure databases

ProteinModelPortaliQ8WUD4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili8 – 28Sequence analysisAdd BLAST21
Coiled coili117 – 144Sequence analysisAdd BLAST28

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3407. Eukaryota.
ENOG4111R31. LUCA.
GeneTreeiENSGT00390000011619.
HOGENOMiHOG000005890.
HOVERGENiHBG059850.
InParanoidiQ8WUD4.
KOiK12871.
PhylomeDBiQ8WUD4.

Family and domain databases

InterProiIPR013169. mRNA_splic_Cwf18.
[Graphical view]
PfamiPF08315. cwf18. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WUD4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEATTAGVGR LEEEALRRKE RLKALREKTG RKDKEDGEPK TKHLREEEEE
60 70 80 90 100
GEKHRELRLR NYVPEDEDLK KRRVPQAKPV AVEEKVKEQL EAAKPEPVIE
110 120 130 140 150
EVDLANLAPR KPDWDLKRDV AKKLEKLKKR TQRAIAELIR ERLKGQEDSL
160
ASAVDAATEQ KTCDSD
Length:166
Mass (Da):19,181
Last modified:March 1, 2002 - v1
Checksum:i8222968EF263F0AD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti97P → S in BAC04857 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096749 mRNA. Translation: BAC04857.1.
BC020830 mRNA. Translation: AAH20830.1.
CCDSiCCDS2748.3.
RefSeqiNP_001264003.1. NM_001277074.1.
UniGeneiHs.631918.
Hs.692157.
Hs.745081.

Genome annotation databases

EnsembliENST00000425441; ENSP00000416263; ENSG00000160799.
GeneIDi151903.
KEGGihsa:151903.
UCSCiuc062jbe.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096749 mRNA. Translation: BAC04857.1.
BC020830 mRNA. Translation: AAH20830.1.
CCDSiCCDS2748.3.
RefSeqiNP_001264003.1. NM_001277074.1.
UniGeneiHs.631918.
Hs.692157.
Hs.745081.

3D structure databases

ProteinModelPortaliQ8WUD4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127412. 35 interactors.
IntActiQ8WUD4. 8 interactors.
MINTiMINT-2812448.
STRINGi9606.ENSP00000292314.

PTM databases

iPTMnetiQ8WUD4.
PhosphoSitePlusiQ8WUD4.

Polymorphism and mutation databases

DMDMi74730697.

Proteomic databases

EPDiQ8WUD4.
MaxQBiQ8WUD4.
PaxDbiQ8WUD4.
PeptideAtlasiQ8WUD4.
PRIDEiQ8WUD4.

Protocols and materials databases

DNASUi151903.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000425441; ENSP00000416263; ENSG00000160799.
GeneIDi151903.
KEGGihsa:151903.
UCSCiuc062jbe.1. human.

Organism-specific databases

CTDi151903.
GeneCardsiCCDC12.
H-InvDBHIX0003254.
HGNCiHGNC:28332. CCDC12.
HPAiHPA056814.
HPA060530.
neXtProtiNX_Q8WUD4.
OpenTargetsiENSG00000160799.
PharmGKBiPA134970849.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3407. Eukaryota.
ENOG4111R31. LUCA.
GeneTreeiENSGT00390000011619.
HOGENOMiHOG000005890.
HOVERGENiHBG059850.
InParanoidiQ8WUD4.
KOiK12871.
PhylomeDBiQ8WUD4.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000160799-MONOMER.

Miscellaneous databases

ChiTaRSiCCDC12. human.
GenomeRNAii151903.
PROiQ8WUD4.

Gene expression databases

BgeeiENSG00000160799.
CleanExiHS_CCDC12.
ExpressionAtlasiQ8WUD4. baseline and differential.
GenevisibleiQ8WUD4. HS.

Family and domain databases

InterProiIPR013169. mRNA_splic_Cwf18.
[Graphical view]
PfamiPF08315. cwf18. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCCD12_HUMAN
AccessioniPrimary (citable) accession number: Q8WUD4
Secondary accession number(s): Q8N8I4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: March 1, 2002
Last modified: November 2, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.