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Q8WUD4

- CCD12_HUMAN

UniProt

Q8WUD4 - CCD12_HUMAN

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Protein

Coiled-coil domain-containing protein 12

Gene
CCDC12
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. protein binding Source: IntAct
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 12
Gene namesi
Name:CCDC12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:28332. CCDC12.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134970849.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 166166Coiled-coil domain-containing protein 12PRO_0000076191Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine2 Publications
Modified residuei53 – 531N6-acetyllysine By similarity
Modified residuei165 – 1651Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ8WUD4.
PaxDbiQ8WUD4.
PeptideAtlasiQ8WUD4.
PRIDEiQ8WUD4.

PTM databases

PhosphoSiteiQ8WUD4.

Expressioni

Gene expression databases

ArrayExpressiQ8WUD4.
BgeeiQ8WUD4.
CleanExiHS_CCDC12.
GenevestigatoriQ8WUD4.

Organism-specific databases

HPAiHPA049307.
HPA056814.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CRNKL1Q9BZJ02EBI-2557572,EBI-1049701

Protein-protein interaction databases

BioGridi127412. 7 interactions.
IntActiQ8WUD4. 5 interactions.
MINTiMINT-2812448.
STRINGi9606.ENSP00000292314.

Structurei

3D structure databases

ProteinModelPortaliQ8WUD4.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili8 – 2821 Reviewed predictionAdd
BLAST
Coiled coili117 – 14428 Reviewed predictionAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG146899.
HOGENOMiHOG000005890.
HOVERGENiHBG059850.
InParanoidiQ8WUD4.
KOiK12871.
OrthoDBiEOG7P8P9B.
PhylomeDBiQ8WUD4.

Family and domain databases

InterProiIPR013169. mRNA_splic_Cwf18.
[Graphical view]
PfamiPF08315. cwf18. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WUD4-1 [UniParc]FASTAAdd to Basket

« Hide

MEATTAGVGR LEEEALRRKE RLKALREKTG RKDKEDGEPK TKHLREEEEE    50
GEKHRELRLR NYVPEDEDLK KRRVPQAKPV AVEEKVKEQL EAAKPEPVIE 100
EVDLANLAPR KPDWDLKRDV AKKLEKLKKR TQRAIAELIR ERLKGQEDSL 150
ASAVDAATEQ KTCDSD 166
Length:166
Mass (Da):19,181
Last modified:March 1, 2002 - v1
Checksum:i8222968EF263F0AD
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti97 – 971P → S in BAC04857. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK096749 mRNA. Translation: BAC04857.1.
BC020830 mRNA. Translation: AAH20830.1.
CCDSiCCDS2748.3.
RefSeqiNP_001264003.1. NM_001277074.1.
UniGeneiHs.631918.
Hs.692157.
Hs.745081.

Genome annotation databases

EnsembliENST00000546280; ENSP00000441327; ENSG00000160799.
GeneIDi151903.
KEGGihsa:151903.

Polymorphism databases

DMDMi74730697.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK096749 mRNA. Translation: BAC04857.1 .
BC020830 mRNA. Translation: AAH20830.1 .
CCDSi CCDS2748.3.
RefSeqi NP_001264003.1. NM_001277074.1.
UniGenei Hs.631918.
Hs.692157.
Hs.745081.

3D structure databases

ProteinModelPortali Q8WUD4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 127412. 7 interactions.
IntActi Q8WUD4. 5 interactions.
MINTi MINT-2812448.
STRINGi 9606.ENSP00000292314.

PTM databases

PhosphoSitei Q8WUD4.

Polymorphism databases

DMDMi 74730697.

Proteomic databases

MaxQBi Q8WUD4.
PaxDbi Q8WUD4.
PeptideAtlasi Q8WUD4.
PRIDEi Q8WUD4.

Protocols and materials databases

DNASUi 151903.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000546280 ; ENSP00000441327 ; ENSG00000160799 .
GeneIDi 151903.
KEGGi hsa:151903.

Organism-specific databases

CTDi 151903.
GeneCardsi GC03M046939.
H-InvDB HIX0003254.
HGNCi HGNC:28332. CCDC12.
HPAi HPA049307.
HPA056814.
neXtProti NX_Q8WUD4.
PharmGKBi PA134970849.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG146899.
HOGENOMi HOG000005890.
HOVERGENi HBG059850.
InParanoidi Q8WUD4.
KOi K12871.
OrthoDBi EOG7P8P9B.
PhylomeDBi Q8WUD4.

Miscellaneous databases

ChiTaRSi CCDC12. human.
GenomeRNAii 151903.
NextBioi 86823.
PROi Q8WUD4.

Gene expression databases

ArrayExpressi Q8WUD4.
Bgeei Q8WUD4.
CleanExi HS_CCDC12.
Genevestigatori Q8WUD4.

Family and domain databases

InterProi IPR013169. mRNA_splic_Cwf18.
[Graphical view ]
Pfami PF08315. cwf18. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-165, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  4. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCCD12_HUMAN
AccessioniPrimary (citable) accession number: Q8WUD4
Secondary accession number(s): Q8N8I4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: March 1, 2002
Last modified: July 9, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM

External Data

Dasty 3

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