Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8WUD1

- RAB2B_HUMAN

UniProt

Q8WUD1 - RAB2B_HUMAN

Protein

Ras-related protein Rab-2B

Gene

RAB2B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Required for protein transport from the endoplasmic reticulum to the Golgi complex.Curated

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi13 – 219GTP
    Nucleotide bindingi61 – 655GTPBy similarity
    Nucleotide bindingi119 – 1224GTP
    Nucleotide bindingi149 – 1513GTP

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-KW

    GO - Biological processi

    1. positive regulation of exocytosis Source: UniProtKB
    2. protein transport Source: UniProtKB-KW
    3. small GTPase mediated signal transduction Source: InterPro
    4. vesicle-mediated transport Source: UniProtKB-KW

    Keywords - Biological processi

    ER-Golgi transport, Protein transport, Transport

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ras-related protein Rab-2B
    Gene namesi
    Name:RAB2B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:20246. RAB2B.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. Golgi membrane Source: UniProtKB-SubCell
    3. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Endoplasmic reticulum, Golgi apparatus, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134865942.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 216216Ras-related protein Rab-2BPRO_0000121071Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi215 – 2151S-geranylgeranyl cysteineBy similarity
    Lipidationi216 – 2161S-geranylgeranyl cysteineBy similarity

    Keywords - PTMi

    Lipoprotein, Prenylation

    Proteomic databases

    MaxQBiQ8WUD1.
    PaxDbiQ8WUD1.
    PRIDEiQ8WUD1.

    PTM databases

    PhosphoSiteiQ8WUD1.

    Expressioni

    Tissue specificityi

    Expressed in kidney, prostate, lung, liver, thymus, colon, pancreas, and skeletal muscle, and low levels in placenta. Not detected in heart, brain, spleen, testis, ovary, small intestine and leukocyte.

    Gene expression databases

    ArrayExpressiQ8WUD1.
    BgeeiQ8WUD1.
    CleanExiHS_RAB2B.
    GenevestigatoriQ8WUD1.

    Organism-specific databases

    HPAiHPA050292.

    Interactioni

    Protein-protein interaction databases

    BioGridi124366. 5 interactions.
    IntActiQ8WUD1. 1 interaction.
    STRINGi9606.ENSP00000302005.

    Structurei

    Secondary structure

    1
    216
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi5 – 1410
    Helixi19 – 2810
    Beta strandi41 – 5010
    Beta strandi53 – 608
    Helixi65 – 673
    Helixi73 – 764
    Beta strandi80 – 878
    Helixi91 – 955
    Helixi97 – 10711
    Beta strandi113 – 1197
    Helixi124 – 1263
    Helixi131 – 14111
    Beta strandi144 – 1485
    Turni150 – 1523
    Helixi156 – 17217

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2A5JX-ray1.50A5-176[»]
    ProteinModelPortaliQ8WUD1.
    SMRiQ8WUD1. Positions 4-176.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ8WUD1.

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi35 – 439Effector regionBy similarity

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. Rab family.Curated

    Phylogenomic databases

    eggNOGiCOG1100.
    HOGENOMiHOG000233968.
    HOVERGENiHBG009351.
    InParanoidiQ8WUD1.
    KOiK07878.
    OMAiEAYINTA.
    OrthoDBiEOG7QK0CV.
    PhylomeDBiQ8WUD1.
    TreeFamiTF300032.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view]
    PfamiPF00071. Ras. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SMARTiSM00175. RAB. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51419. RAB. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8WUD1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTYAYLFKYI IIGDTGVGKS CLLLQFTDKR FQPVHDLTIG VEFGARMVNI    50
    DGKQIKLQIW DTAGQESFRS ITRSYYRGAA GALLVYDITR RETFNHLTSW 100
    LEDARQHSSS NMVIMLIGNK SDLESRRDVK REEGEAFARE HGLIFMETSA 150
    KTACNVEEAF INTAKEIYRK IQQGLFDVHN EANGIKIGPQ QSISTSVGPS 200
    ASQRNSRDIG SNSGCC 216
    Length:216
    Mass (Da):24,214
    Last modified:March 1, 2002 - v1
    Checksum:i80A73F6D259701D8
    GO
    Isoform 2 (identifier: Q8WUD1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-76: MTYAYLFKYI...SFRSITRSYY → MENKSNCKSGI

    Show »
    Length:151
    Mass (Da):16,667
    Checksum:i3B7E62B17FFDB278
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti168 – 1681Y → H in AAN86142. (PubMed:12376746)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti212 – 2121N → T.
    Corresponds to variant rs17106411 [ dbSNP | Ensembl ].
    VAR_051709

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 7676MTYAY…TRSYY → MENKSNCKSGI in isoform 2. 2 PublicationsVSP_055829Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF468652 mRNA. Translation: AAN86142.1.
    AK296057 mRNA. Translation: BAG58820.1.
    AK315354 mRNA. Translation: BAG37750.1.
    CH471078 Genomic DNA. Translation: EAW66382.1.
    CH471078 Genomic DNA. Translation: EAW66383.1.
    BC020839 mRNA. Translation: AAH20839.1.
    BC066366 mRNA. Translation: AAH66366.1.
    CCDSiCCDS9570.1.
    RefSeqiNP_116235.2. NM_032846.3.
    UniGeneiHs.22399.

    Genome annotation databases

    EnsembliENST00000397762; ENSP00000380869; ENSG00000129472. [Q8WUD1-1]
    GeneIDi84932.
    KEGGihsa:84932.
    UCSCiuc010tls.2. human.

    Polymorphism databases

    DMDMi28436385.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF468652 mRNA. Translation: AAN86142.1 .
    AK296057 mRNA. Translation: BAG58820.1 .
    AK315354 mRNA. Translation: BAG37750.1 .
    CH471078 Genomic DNA. Translation: EAW66382.1 .
    CH471078 Genomic DNA. Translation: EAW66383.1 .
    BC020839 mRNA. Translation: AAH20839.1 .
    BC066366 mRNA. Translation: AAH66366.1 .
    CCDSi CCDS9570.1.
    RefSeqi NP_116235.2. NM_032846.3.
    UniGenei Hs.22399.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2A5J X-ray 1.50 A 5-176 [» ]
    ProteinModelPortali Q8WUD1.
    SMRi Q8WUD1. Positions 4-176.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124366. 5 interactions.
    IntActi Q8WUD1. 1 interaction.
    STRINGi 9606.ENSP00000302005.

    PTM databases

    PhosphoSitei Q8WUD1.

    Polymorphism databases

    DMDMi 28436385.

    Proteomic databases

    MaxQBi Q8WUD1.
    PaxDbi Q8WUD1.
    PRIDEi Q8WUD1.

    Protocols and materials databases

    DNASUi 84932.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000397762 ; ENSP00000380869 ; ENSG00000129472 . [Q8WUD1-1 ]
    GeneIDi 84932.
    KEGGi hsa:84932.
    UCSCi uc010tls.2. human.

    Organism-specific databases

    CTDi 84932.
    GeneCardsi GC14M021927.
    H-InvDB HIX0011509.
    HGNCi HGNC:20246. RAB2B.
    HPAi HPA050292.
    MIMi 607466. gene.
    neXtProti NX_Q8WUD1.
    PharmGKBi PA134865942.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1100.
    HOGENOMi HOG000233968.
    HOVERGENi HBG009351.
    InParanoidi Q8WUD1.
    KOi K07878.
    OMAi EAYINTA.
    OrthoDBi EOG7QK0CV.
    PhylomeDBi Q8WUD1.
    TreeFami TF300032.

    Miscellaneous databases

    EvolutionaryTracei Q8WUD1.
    GenomeRNAii 84932.
    NextBioi 75368.
    PROi Q8WUD1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8WUD1.
    Bgeei Q8WUD1.
    CleanExi HS_RAB2B.
    Genevestigatori Q8WUD1.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view ]
    Pfami PF00071. Ras. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SMARTi SM00175. RAB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51419. RAB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and characterization of a novel human Rab (Rab2B) gene."
      Ni X., Ma Y., Cheng H., Jiang M., Guo L., Ji C., Gu S., Cao Y., Xie Y., Mao Y.
      J. Hum. Genet. 47:548-551(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Subthalamic nucleus.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Skin and Testis.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    6. "Crystal structure of human RAB2B."
      Structural genomics consortium (SGC)
      Submitted (FEB-2009) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) OF 5-176 IN COMPLEX WITH GDP.

    Entry informationi

    Entry nameiRAB2B_HUMAN
    AccessioniPrimary (citable) accession number: Q8WUD1
    Secondary accession number(s): B2RD03, D3DS24, Q6NZ33
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 12, 2003
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 119 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3