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Q8WUD1

- RAB2B_HUMAN

UniProt

Q8WUD1 - RAB2B_HUMAN

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Protein

Ras-related protein Rab-2B

Gene

RAB2B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Required for protein transport from the endoplasmic reticulum to the Golgi complex.Curated

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi13 – 219GTP
Nucleotide bindingi61 – 655GTPBy similarity
Nucleotide bindingi119 – 1224GTP
Nucleotide bindingi149 – 1513GTP

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW

GO - Biological processi

  1. positive regulation of exocytosis Source: UniProtKB
  2. protein transport Source: UniProtKB-KW
  3. small GTPase mediated signal transduction Source: InterPro
  4. vesicle-mediated transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-2B
Gene namesi
Name:RAB2B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:20246. RAB2B.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. extracellular vesicular exosome Source: UniProtKB
  3. Golgi apparatus Source: UniProtKB-KW
  4. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134865942.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 216216Ras-related protein Rab-2BPRO_0000121071Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi215 – 2151S-geranylgeranyl cysteineBy similarity
Lipidationi216 – 2161S-geranylgeranyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Prenylation

Proteomic databases

MaxQBiQ8WUD1.
PaxDbiQ8WUD1.
PRIDEiQ8WUD1.

PTM databases

PhosphoSiteiQ8WUD1.

Expressioni

Tissue specificityi

Expressed in kidney, prostate, lung, liver, thymus, colon, pancreas, and skeletal muscle, and low levels in placenta. Not detected in heart, brain, spleen, testis, ovary, small intestine and leukocyte.

Gene expression databases

BgeeiQ8WUD1.
CleanExiHS_RAB2B.
ExpressionAtlasiQ8WUD1. baseline and differential.
GenevestigatoriQ8WUD1.

Organism-specific databases

HPAiHPA050292.

Interactioni

Protein-protein interaction databases

BioGridi124366. 5 interactions.
IntActiQ8WUD1. 1 interaction.
STRINGi9606.ENSP00000302005.

Structurei

Secondary structure

1
216
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi5 – 1410
Helixi19 – 2810
Beta strandi41 – 5010
Beta strandi53 – 608
Helixi65 – 673
Helixi73 – 764
Beta strandi80 – 878
Helixi91 – 955
Helixi97 – 10711
Beta strandi113 – 1197
Helixi124 – 1263
Helixi131 – 14111
Beta strandi144 – 1485
Turni150 – 1523
Helixi156 – 17217

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2A5JX-ray1.50A5-176[»]
ProteinModelPortaliQ8WUD1.
SMRiQ8WUD1. Positions 4-176.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8WUD1.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi35 – 439Effector regionBy similarity

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiCOG1100.
GeneTreeiENSGT00760000118841.
HOGENOMiHOG000233968.
HOVERGENiHBG009351.
InParanoidiQ8WUD1.
KOiK07878.
OMAiEAYINTA.
OrthoDBiEOG7QK0CV.
PhylomeDBiQ8WUD1.
TreeFamiTF300032.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamiPF00071. Ras. 1 hit.
[Graphical view]
PRINTSiPR00449. RASTRNSFRMNG.
SMARTiSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51419. RAB. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8WUD1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTYAYLFKYI IIGDTGVGKS CLLLQFTDKR FQPVHDLTIG VEFGARMVNI
60 70 80 90 100
DGKQIKLQIW DTAGQESFRS ITRSYYRGAA GALLVYDITR RETFNHLTSW
110 120 130 140 150
LEDARQHSSS NMVIMLIGNK SDLESRRDVK REEGEAFARE HGLIFMETSA
160 170 180 190 200
KTACNVEEAF INTAKEIYRK IQQGLFDVHN EANGIKIGPQ QSISTSVGPS
210
ASQRNSRDIG SNSGCC
Length:216
Mass (Da):24,214
Last modified:March 1, 2002 - v1
Checksum:i80A73F6D259701D8
GO
Isoform 2 (identifier: Q8WUD1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-76: MTYAYLFKYI...SFRSITRSYY → MENKSNCKSGI

Show »
Length:151
Mass (Da):16,667
Checksum:i3B7E62B17FFDB278
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti168 – 1681Y → H in AAN86142. (PubMed:12376746)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti212 – 2121N → T.
Corresponds to variant rs17106411 [ dbSNP | Ensembl ].
VAR_051709

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 7676MTYAY…TRSYY → MENKSNCKSGI in isoform 2. 2 PublicationsVSP_055829Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF468652 mRNA. Translation: AAN86142.1.
AK296057 mRNA. Translation: BAG58820.1.
AK315354 mRNA. Translation: BAG37750.1.
CH471078 Genomic DNA. Translation: EAW66382.1.
CH471078 Genomic DNA. Translation: EAW66383.1.
BC020839 mRNA. Translation: AAH20839.1.
BC066366 mRNA. Translation: AAH66366.1.
CCDSiCCDS9570.1. [Q8WUD1-1]
RefSeqiNP_001156852.1. NM_001163380.1.
NP_116235.2. NM_032846.3. [Q8WUD1-1]
UniGeneiHs.22399.

Genome annotation databases

EnsembliENST00000397762; ENSP00000380869; ENSG00000129472. [Q8WUD1-1]
GeneIDi84932.
KEGGihsa:84932.
UCSCiuc010tls.2. human. [Q8WUD1-1]

Polymorphism databases

DMDMi28436385.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF468652 mRNA. Translation: AAN86142.1 .
AK296057 mRNA. Translation: BAG58820.1 .
AK315354 mRNA. Translation: BAG37750.1 .
CH471078 Genomic DNA. Translation: EAW66382.1 .
CH471078 Genomic DNA. Translation: EAW66383.1 .
BC020839 mRNA. Translation: AAH20839.1 .
BC066366 mRNA. Translation: AAH66366.1 .
CCDSi CCDS9570.1. [Q8WUD1-1 ]
RefSeqi NP_001156852.1. NM_001163380.1.
NP_116235.2. NM_032846.3. [Q8WUD1-1 ]
UniGenei Hs.22399.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2A5J X-ray 1.50 A 5-176 [» ]
ProteinModelPortali Q8WUD1.
SMRi Q8WUD1. Positions 4-176.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124366. 5 interactions.
IntActi Q8WUD1. 1 interaction.
STRINGi 9606.ENSP00000302005.

PTM databases

PhosphoSitei Q8WUD1.

Polymorphism databases

DMDMi 28436385.

Proteomic databases

MaxQBi Q8WUD1.
PaxDbi Q8WUD1.
PRIDEi Q8WUD1.

Protocols and materials databases

DNASUi 84932.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000397762 ; ENSP00000380869 ; ENSG00000129472 . [Q8WUD1-1 ]
GeneIDi 84932.
KEGGi hsa:84932.
UCSCi uc010tls.2. human. [Q8WUD1-1 ]

Organism-specific databases

CTDi 84932.
GeneCardsi GC14M021927.
H-InvDB HIX0011509.
HGNCi HGNC:20246. RAB2B.
HPAi HPA050292.
MIMi 607466. gene.
neXtProti NX_Q8WUD1.
PharmGKBi PA134865942.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1100.
GeneTreei ENSGT00760000118841.
HOGENOMi HOG000233968.
HOVERGENi HBG009351.
InParanoidi Q8WUD1.
KOi K07878.
OMAi EAYINTA.
OrthoDBi EOG7QK0CV.
PhylomeDBi Q8WUD1.
TreeFami TF300032.

Miscellaneous databases

EvolutionaryTracei Q8WUD1.
GenomeRNAii 84932.
NextBioi 75368.
PROi Q8WUD1.
SOURCEi Search...

Gene expression databases

Bgeei Q8WUD1.
CleanExi HS_RAB2B.
ExpressionAtlasi Q8WUD1. baseline and differential.
Genevestigatori Q8WUD1.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view ]
Pfami PF00071. Ras. 1 hit.
[Graphical view ]
PRINTSi PR00449. RASTRNSFRMNG.
SMARTi SM00175. RAB. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00231. small_GTP. 1 hit.
PROSITEi PS51419. RAB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of a novel human Rab (Rab2B) gene."
    Ni X., Ma Y., Cheng H., Jiang M., Guo L., Ji C., Gu S., Cao Y., Xie Y., Mao Y.
    J. Hum. Genet. 47:548-551(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Subthalamic nucleus.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Skin and Testis.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "Crystal structure of human RAB2B."
    Structural genomics consortium (SGC)
    Submitted (FEB-2009) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) OF 5-176 IN COMPLEX WITH GDP.

Entry informationi

Entry nameiRAB2B_HUMAN
AccessioniPrimary (citable) accession number: Q8WUD1
Secondary accession number(s): B2RD03, D3DS24, Q6NZ33
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: March 1, 2002
Last modified: October 29, 2014
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3