Q8WUD1 (RAB2B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ras-related protein Rab-2B

Gene names

Name:

RAB2B

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	216 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Required for protein transport from the endoplasmic reticulum to the Golgi complex Potential.
Subcellular location	Cell membrane; Lipid-anchor; Cytoplasmic side Potential. Endoplasmic reticulum membrane Potential. Golgi apparatus membrane Potential.
Tissue specificity	Expressed in kidney, prostate, lung, liver, thymus, colon, pancreas, and skeletal muscle, and low levels in placenta. Not detected in heart, brain, spleen, testis, ovary, small intestine and leukocyte.
Sequence similarities	Belongs to the small GTPase superfamily. Rab family.

Ontologies

Keywords
Biological process	ER-Golgi transport Protein transport Transport
Cellular component	Cell membrane Endoplasmic reticulum Golgi apparatus Membrane
Coding sequence diversity	Polymorphism
Ligand	GTP-binding Nucleotide-binding
PTM	Lipoprotein Prenylation
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	positive regulation of exocytosis Inferred from mutant phenotype PubMed 19966785. Source: UniProtKB protein transport Inferred from electronic annotation. Source: UniProtKB-KW small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro vesicle-mediated transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	Golgi membrane Inferred from electronic annotation. Source: UniProtKB-SubCell endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 216

216

Ras-related protein Rab-2B

PRO_0000121071

Regions

Nucleotide binding

13 – 21

9

GTP

Nucleotide binding

61 – 65

5

GTP By similarity

Nucleotide binding

119 – 122

4

GTP

Nucleotide binding

149 – 151

3

GTP

Motif

35 – 43

9

Effector region By similarity

Amino acid modifications

Lipidation

215

1

S-geranylgeranyl cysteine By similarity

Lipidation

216

1

S-geranylgeranyl cysteine By similarity

Natural variations

Natural variant

212

1

N → T.
Corresponds to variant rs17106411 [ dbSNP | Ensembl ].

VAR_051709

Experimental info

Sequence conflict

168

1

Y → H in AAN86142. Ref.1

Secondary structure

1

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216

Helix Strand Turn

Details...

Beta strand

5 – 14

10

Helix

19 – 28

10

Beta strand

41 – 50

10

Beta strand

53 – 60

8

Helix

65 – 67

3

Helix

73 – 76

4

Beta strand

80 – 87

8

Helix

91 – 95

5

Helix

97 – 107

11

Beta strand

113 – 119

7

Helix

124 – 126

3

Helix

131 – 141

11

Beta strand

144 – 148

5

Turn

150 – 152

3

Helix

156 – 172

17

Sequences

	Sequence		Length	Mass (Da)
	Q8WUD1 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 80A73F6D259701D8	FASTA	216	24,214
	10 20 30 40 50 60 MTYAYLFKYI IIGDTGVGKS CLLLQFTDKR FQPVHDLTIG VEFGARMVNI DGKQIKLQIW 70 80 90 100 110 120 DTAGQESFRS ITRSYYRGAA GALLVYDITR RETFNHLTSW LEDARQHSSS NMVIMLIGNK 130 140 150 160 170 180 SDLESRRDVK REEGEAFARE HGLIFMETSA KTACNVEEAF INTAKEIYRK IQQGLFDVHN 190 200 210 EANGIKIGPQ QSISTSVGPS ASQRNSRDIG SNSGCC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and characterization of a novel human Rab (Rab2B) gene." Ni X., Ma Y., Cheng H., Jiang M., Guo L., Ji C., Gu S., Cao Y., Xie Y., Mao Y. J. Hum. Genet. 47:548-551(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skin.
[5]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[6]	"Crystal structure of human RAB2B." Structural genomics consortium (SGC) Submitted (FEB-2009) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) OF 5-176 IN COMPLEX WITH GDP.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF468652 mRNA. Translation: AAN86142.1.
AK315354 mRNA. Translation: BAG37750.1.
CH471078 Genomic DNA. Translation: EAW66382.1.
CH471078 Genomic DNA. Translation: EAW66383.1.
BC020839 mRNA. Translation: AAH20839.1.

IPI

IPI00102896.

RefSeq

NP_116235.2. NM_032846.3.

UniGene

Hs.22399.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2A5J	X-ray	1.50	A	5-176	[»]

ProteinModelPortal

Q8WUD1.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q8WUD1. 1 interaction.

STRING

9606.ENSP00000302005.

PTM databases

PhosphoSite

Q8WUD1.

Polymorphism databases

DMDM

28436385.

Proteomic databases

PaxDb

Q8WUD1.

PRIDE

Q8WUD1.

Protocols and materials databases

DNASU

84932.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000397762; ENSP00000380869; ENSG00000129472.

GeneID

84932.

KEGG

hsa:84932.

UCSC

uc010tls.2. human.

Organism-specific databases

CTD

84932.

GeneCards

GC14M021927.

H-InvDB

HIX0011509.

HGNC

HGNC:20246. RAB2B.

HPA

HPA050292.

MIM

607466. gene.

neXtProt

NX_Q8WUD1.

PharmGKB

PA134865942.

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG1100.

HOGENOM

HOG000233968.

HOVERGEN

HBG009351.

InParanoid

Q8WUD1.

KO

K07878.

OMA

RRDTFTH.

OrthoDB

EOG41G354.

PhylomeDB

Q8WUD1.

Gene expression databases

ArrayExpress

Q8WUD1.

Bgee

Q8WUD1.

CleanEx

HS_RAB2B.

Genevestigator

Q8WUD1.

GermOnline

ENSG00000129472. Homo sapiens.

Family and domain databases

InterPro

IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]

Pfam

PF00071. Ras. 1 hit.
[Graphical view]

PRINTS

PR00449. RASTRNSFRMNG.

SMART

SM00175. RAB. 1 hit.
[Graphical view]

TIGRFAMs

TIGR00231. small_GTP. 1 hit.

PROSITE

PS51419. RAB. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q8WUD1.

GenomeRNAi

84932.

NextBio

75368.

SOURCE

Search...

Entry information

Entry name

RAB2B_HUMAN

Accession

Primary (citable) accession number: Q8WUD1
Secondary accession number(s): B2RD03, D3DS24

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 12, 2003
Last sequence update:	March 1, 2002
Last modified:	May 1, 2013
This is version 108 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.