Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q8WUD1 (RAB2B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 117. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ras-related protein Rab-2B
Gene names
Name:RAB2B
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length216 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for protein transport from the endoplasmic reticulum to the Golgi complex Potential.

Subcellular location

Cell membrane; Lipid-anchor; Cytoplasmic side Potential. Endoplasmic reticulum membrane Potential. Golgi apparatus membrane Potential.

Tissue specificity

Expressed in kidney, prostate, lung, liver, thymus, colon, pancreas, and skeletal muscle, and low levels in placenta. Not detected in heart, brain, spleen, testis, ovary, small intestine and leukocyte.

Sequence similarities

Belongs to the small GTPase superfamily. Rab family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 216216Ras-related protein Rab-2B
PRO_0000121071

Regions

Nucleotide binding13 – 219GTP
Nucleotide binding61 – 655GTP By similarity
Nucleotide binding119 – 1224GTP
Nucleotide binding149 – 1513GTP
Motif35 – 439Effector region By similarity

Amino acid modifications

Lipidation2151S-geranylgeranyl cysteine By similarity
Lipidation2161S-geranylgeranyl cysteine By similarity

Natural variations

Natural variant2121N → T.
Corresponds to variant rs17106411 [ dbSNP | Ensembl ].
VAR_051709

Experimental info

Sequence conflict1681Y → H in AAN86142. Ref.1

Secondary structure

............................... 216
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q8WUD1 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 80A73F6D259701D8

FASTA21624,214
        10         20         30         40         50         60 
MTYAYLFKYI IIGDTGVGKS CLLLQFTDKR FQPVHDLTIG VEFGARMVNI DGKQIKLQIW 

        70         80         90        100        110        120 
DTAGQESFRS ITRSYYRGAA GALLVYDITR RETFNHLTSW LEDARQHSSS NMVIMLIGNK 

       130        140        150        160        170        180 
SDLESRRDVK REEGEAFARE HGLIFMETSA KTACNVEEAF INTAKEIYRK IQQGLFDVHN 

       190        200        210 
EANGIKIGPQ QSISTSVGPS ASQRNSRDIG SNSGCC 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning and characterization of a novel human Rab (Rab2B) gene."
Ni X., Ma Y., Cheng H., Jiang M., Guo L., Ji C., Gu S., Cao Y., Xie Y., Mao Y.
J. Hum. Genet. 47:548-551(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Skin.
[5]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[6]"Crystal structure of human RAB2B."
Structural genomics consortium (SGC)
Submitted (FEB-2009) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) OF 5-176 IN COMPLEX WITH GDP.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF468652 mRNA. Translation: AAN86142.1.
AK315354 mRNA. Translation: BAG37750.1.
CH471078 Genomic DNA. Translation: EAW66382.1.
CH471078 Genomic DNA. Translation: EAW66383.1.
BC020839 mRNA. Translation: AAH20839.1.
CCDSCCDS9570.1.
RefSeqNP_116235.2. NM_032846.3.
UniGeneHs.22399.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2A5JX-ray1.50A5-176[»]
ProteinModelPortalQ8WUD1.
SMRQ8WUD1. Positions 4-176.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid124366. 5 interactions.
IntActQ8WUD1. 1 interaction.
STRING9606.ENSP00000302005.

PTM databases

PhosphoSiteQ8WUD1.

Polymorphism databases

DMDM28436385.

Proteomic databases

MaxQBQ8WUD1.
PaxDbQ8WUD1.
PRIDEQ8WUD1.

Protocols and materials databases

DNASU84932.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000397762; ENSP00000380869; ENSG00000129472.
GeneID84932.
KEGGhsa:84932.
UCSCuc010tls.2. human.

Organism-specific databases

CTD84932.
GeneCardsGC14M021927.
H-InvDBHIX0011509.
HGNCHGNC:20246. RAB2B.
HPAHPA050292.
MIM607466. gene.
neXtProtNX_Q8WUD1.
PharmGKBPA134865942.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG1100.
HOGENOMHOG000233968.
HOVERGENHBG009351.
InParanoidQ8WUD1.
KOK07878.
OMAEAYINTA.
OrthoDBEOG7QK0CV.
PhylomeDBQ8WUD1.
TreeFamTF300032.

Gene expression databases

ArrayExpressQ8WUD1.
BgeeQ8WUD1.
CleanExHS_RAB2B.
GenevestigatorQ8WUD1.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
IPR003579. Small_GTPase_Rab_type.
[Graphical view]
PfamPF00071. Ras. 1 hit.
[Graphical view]
PRINTSPR00449. RASTRNSFRMNG.
SMARTSM00175. RAB. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00231. small_GTP. 1 hit.
PROSITEPS51419. RAB. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ8WUD1.
GenomeRNAi84932.
NextBio75368.
PROQ8WUD1.
SOURCESearch...

Entry information

Entry nameRAB2B_HUMAN
AccessionPrimary (citable) accession number: Q8WUD1
Secondary accession number(s): B2RD03, D3DS24
Entry history
Integrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: March 1, 2002
Last modified: July 9, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM