Q8WUB8 (PHF10_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
PHD finger protein 10

Alternative name(s):
BRG1-associated factor 45a
Short name=BAF45a
XAP135

Gene names

Name:	PHF10
Synonyms:	BAF45A

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	498 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in transcription activity regulation by chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth By similarity.
Subunit structure	Component of neural progenitors-specific chromatin remodeling complex (npBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A and actin. Interacts with ACTL6A/BAF53A, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A and PBRM1/BAF180 By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the SAYP family. Contains 2 PHD-type zinc fingers.
Caution	It is uncertain whether Met-1 or Met-89 is the initiator.
Sequence caution	The sequence AAH20954.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence AAI10324.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence AAK27451.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence BAA91934.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAD96332.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence CAG33554.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence CAI12316.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Neurogenesis Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Domain	Repeat Zinc-finger
Ligand	Metal-binding Zinc
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	nervous system development Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	npBAF complex Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8WUB8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8WUB8-2)

Also known as: B;

The sequence of this isoform differs from the canonical sequence as follows:
     109-110: Missing.

Isoform 3 (identifier: Q8WUB8-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-47: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.11
	Chain	2 – 498	497	PHD finger protein 10		PRO_0000059297
Regions
	Zinc finger	379 – 436	58	PHD-type 1; degenerate
	Zinc finger	438 – 481	44	PHD-type 2; degenerate
	Region	89 – 295	207	SAY
	Region	89 – 185	97	Essential to induce neural progenitor proliferation By similarity
	Region	292 – 334	43	Essential to induce neural progenitor proliferation By similarity
Amino acid modifications
	Modified residue	2	1	N-acetylalanine Ref.11
	Modified residue	12	1	Phosphoserine Ref.11
	Modified residue	36	1	Phosphoserine Ref.12
	Modified residue	50	1	Phosphoserine Ref.12
	Modified residue	270	1	Phosphoserine Ref.9 Ref.11
	Modified residue	297	1	Phosphoserine Ref.9 Ref.10 Ref.11 Ref.12
	Modified residue	301	1	Phosphoserine Ref.9 Ref.10 Ref.11 Ref.12
	Modified residue	327	1	Phosphoserine Ref.10 Ref.12
Natural variations
	Alternative sequence	1 – 47	47	Missing in isoform 3.		VSP_039090
	Alternative sequence	109 – 110	2	Missing in isoform 2.		VSP_013440
Experimental info
	Sequence conflict	126	1	L → P in AAK27451. Ref.4
	Sequence conflict	246	1	E → G in AAK27451. Ref.4
	Sequence conflict	275	1	R → W in AAK27451. Ref.4
	Sequence conflict	286 – 287	2	PP → AT in AAK27451. Ref.4
	Sequence conflict	325	1	N → K in AAK27451. Ref.4
	Sequence conflict	332	1	P → S in AAK27451. Ref.4
	Sequence conflict	357	1	G → A in AAK27451. Ref.4
	Sequence conflict	365	1	K → N in AAK27451. Ref.4
	Sequence conflict	422	1	M → T in BAD96332. Ref.7

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 18, 2010. Version 3. Checksum: 05EFDABD2000C2B7	FASTA	498	56,051
	10 20 30 40 50 60 MAAAAGPGAA LSPRPCDSDP ATPGAQSPKD DNEDNSNDGT QPSKRRRMGS GDSSRSCETS 70 80 90 100 110 120 SQDLGFSYYP AENLIEYKWP PDETGEYYML QEQVSEYLGV TSFKRKYPDL ERRDLSHKEK 130 140 150 160 170 180 LYLRELNVIT ETQCTLGLTA LRSDEVIDLM IKEYPAKHAE YSVILQEKER QRITDHYKEY 190 200 210 220 230 240 SQMQQQNTQK VEASKVPEYI KKAAKKAAEF NSNLNRERME ERRAYFDLQT HVIQVPQGKY 250 260 270 280 290 300 KVLPTERTKV SSYPVALIPG QFQEYYKRYS PDELRYLPLN TALYEPPLDP ELPALDSDGD 310 320 330 340 350 360 SDDGEDGRGD EKRKNKGTSD SSSGNVSEGE SPPDSQEDSF QGRQKSKDKA ATPRKDGPKR 370 380 390 400 410 420 SVLSKSVPGY KPKVIPNAIC GICLKGKESN KKGKAESLIH CSQCENSGHP SCLDMTMELV 430 440 450 460 470 480 SMIKTYPWQC MECKTCIICG QPHHEEEMMF CDMCDRGYHT FCVGLGAIPS GRWICDCCQR 490 APPTPRKVGR RGKNSKEG
	Isoform 2 (B) [UniParc]. Checksum: 6D4EAF7B86CA38C1	FASTA	496	55,823
	10 20 30 40 50 60 MAAAAGPGAA LSPRPCDSDP ATPGAQSPKD DNEDNSNDGT QPSKRRRMGS GDSSRSCETS 70 80 90 100 110 120 SQDLGFSYYP AENLIEYKWP PDETGEYYML QEQVSEYLGV TSFKRKYPER RDLSHKEKLY 130 140 150 160 170 180 LRELNVITET QCTLGLTALR SDEVIDLMIK EYPAKHAEYS VILQEKERQR ITDHYKEYSQ 190 200 210 220 230 240 MQQQNTQKVE ASKVPEYIKK AAKKAAEFNS NLNRERMEER RAYFDLQTHV IQVPQGKYKV 250 260 270 280 290 300 LPTERTKVSS YPVALIPGQF QEYYKRYSPD ELRYLPLNTA LYEPPLDPEL PALDSDGDSD 310 320 330 340 350 360 DGEDGRGDEK RKNKGTSDSS SGNVSEGESP PDSQEDSFQG RQKSKDKAAT PRKDGPKRSV 370 380 390 400 410 420 LSKSVPGYKP KVIPNAICGI CLKGKESNKK GKAESLIHCS QCENSGHPSC LDMTMELVSM 430 440 450 460 470 480 IKTYPWQCME CKTCIICGQP HHEEEMMFCD MCDRGYHTFC VGLGAIPSGR WICDCCQRAP 490 PTPRKVGRRG KNSKEG
	Isoform 3 [UniParc]. Checksum: 8F3DE3D2A999E8A0	FASTA	451	51,290
	10 20 30 40 50 60 MGSGDSSRSC ETSSQDLGFS YYPAENLIEY KWPPDETGEY YMLQEQVSEY LGVTSFKRKY 70 80 90 100 110 120 PDLERRDLSH KEKLYLRELN VITETQCTLG LTALRSDEVI DLMIKEYPAK HAEYSVILQE 130 140 150 160 170 180 KERQRITDHY KEYSQMQQQN TQKVEASKVP EYIKKAAKKA AEFNSNLNRE RMEERRAYFD 190 200 210 220 230 240 LQTHVIQVPQ GKYKVLPTER TKVSSYPVAL IPGQFQEYYK RYSPDELRYL PLNTALYEPP 250 260 270 280 290 300 LDPELPALDS DGDSDDGEDG RGDEKRKNKG TSDSSSGNVS EGESPPDSQE DSFQGRQKSK 310 320 330 340 350 360 DKAATPRKDG PKRSVLSKSV PGYKPKVIPN AICGICLKGK ESNKKGKAES LIHCSQCENS 370 380 390 400 410 420 GHPSCLDMTM ELVSMIKTYP WQCMECKTCI ICGQPHHEEE MMFCDMCDRG YHTFCVGLGA 430 440 450 IPSGRWICDC CQRAPPTPRK VGRRGKNSKE G

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"PHF10 is required for cell proliferation in normal and SV40-immortalized human fibroblast cells." Banga S.S., Peng L., Dasgupta T., Palejwala V., Ozer H.L. Cytogenet. Genome Res. 126:227-242(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
[2]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Colon and Skin.
[4]	"Physical and genetic characterization reveals a pseudogene, an evolutionary junction, and unstable loci in distal Xq28." Aradhya S., Woffendin H., Bonnen P., Heiss N.S., Yamagata T., Esposito T., Bardaro T., Poustka A., D'Urso M., Kenwrick S., Nelson D.L. Genomics 79:31-40(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 73-498 (ISOFORM 1), ALTERNATIVE SPLICING.
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 87-498 (ISOFORM 1). Tissue: Placenta.
[6]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 89-498 (ISOFORM 1).
[7]	Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 89-498 (ISOFORM 1). Tissue: Artery smooth muscle.
[8]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[9]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-270; SER-297 AND SER-301, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[10]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-297; SER-301 AND SER-327, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[11]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-12; SER-270; SER-297 AND SER-301, MASS SPECTROMETRY, CLEAVAGE OF INITIATOR METHIONINE. Tissue: Cervix carcinoma.
[12]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-36; SER-50; SER-297; SER-301 AND SER-327, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL513547 Genomic DNA. Translation: CAI12316.1. Sequence problems. BC020954 mRNA. Translation: AAH20954.1. Different initiation. BC110323 mRNA. Translation: AAI10324.1. Different initiation. AF338735 Genomic DNA. Translation: AAK27451.1. Sequence problems. AK001837 mRNA. Translation: BAA91934.1. Different initiation. CR457273 mRNA. Translation: CAG33554.1. Different initiation. AK222612 mRNA. Translation: BAD96332.1. Different initiation.
IPI	IPI00940864. IPI00941847. IPI00964464.
RefSeq	NP_060758.2. NM_018288.3. NP_579866.2. NM_133325.2.
UniGene	Hs.435933.
3D structure databases
ProteinModelPortal	Q8WUB8.
SMR	Q8WUB8. Positions 376-479.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8WUB8. 10 interactions.
MINT	MINT-1373208.
STRING	9606.ENSP00000341805.
PTM databases
PhosphoSite	Q8WUB8.
Polymorphism databases
DMDM	296439276.
Proteomic databases
PaxDb	Q8WUB8.
PRIDE	Q8WUB8.
Protocols and materials databases
DNASU	55274.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000339209; ENSP00000341805; ENSG00000130024. ENST00000366780; ENSP00000355743; ENSG00000130024.
GeneID	55274.
KEGG	hsa:55274.
UCSC	uc011egy.2. human. uc011egz.2. human.
Organism-specific databases
CTD	55274.
GeneCards	GC06M170104.
HGNC	HGNC:18250. PHF10.
MIM	613069. gene.
neXtProt	NX_Q8WUB8.
PharmGKB	PA134972675.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG279558.
HOGENOM	HOG000286026.
HOVERGEN	HBG053581.
InParanoid	Q8WUB8.
OMA	CETSSQD.
OrthoDB	EOG4BCDNG.
Gene expression databases
Bgee	Q8WUB8.
CleanEx	HS_PHF10.
Genevestigator	Q8WUB8.
GermOnline	ENSG00000130024. Homo sapiens.
Family and domain databases
Gene3D	3.30.40.10. 2 hits.
InterPro	IPR011011. Znf_FYVE_PHD. IPR001965. Znf_PHD. IPR019787. Znf_PHD-finger. IPR013083. Znf_RING/FYVE/PHD. [Graphical view]
Pfam	PF00628. PHD. 1 hit. [Graphical view]
SMART	SM00249. PHD. 2 hits. [Graphical view]
SUPFAM	SSF57903. FYVE_PHD_ZnF. 2 hits.
PROSITE	PS01359. ZF_PHD_1. 1 hit. PS50016. ZF_PHD_2. 2 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	55274.
NextBio	59399.
SOURCE	Search...

Entry information

Entry name

PHF10_HUMAN

Accession

Primary (citable) accession number: Q8WUB8
Secondary accession number(s): Q2YDA3 , Q53HG8, Q9BXD2, Q9NV26

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2005
Last sequence update:	May 18, 2010
Last modified:	May 1, 2013
This is version 99 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.