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Q8WUB8

- PHF10_HUMAN

UniProt

Q8WUB8 - PHF10_HUMAN

Protein

PHD finger protein 10

Gene

PHF10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 3 (18 May 2010)
      Previous versions | rss
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    Functioni

    Involved in transcription activity regulation by chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri379 – 43658PHD-type 1; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri438 – 48144PHD-type 2; degeneratePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. zinc ion binding Source: InterPro

    GO - Biological processi

    1. nervous system development Source: UniProtKB-KW
    2. regulation of transcription, DNA-templated Source: UniProtKB-KW
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Neurogenesis, Transcription, Transcription regulation

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    PHD finger protein 10
    Alternative name(s):
    BRG1-associated factor 45a
    Short name:
    BAF45a
    XAP135
    Gene namesi
    Name:PHF10
    Synonyms:BAF45A
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:18250. PHF10.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. npBAF complex Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134972675.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 498497PHD finger protein 10PRO_0000059297Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine1 Publication
    Modified residuei12 – 121Phosphoserine1 Publication
    Modified residuei36 – 361Phosphoserine1 Publication
    Modified residuei50 – 501Phosphoserine1 Publication
    Modified residuei270 – 2701Phosphoserine2 Publications
    Modified residuei297 – 2971Phosphoserine4 Publications
    Modified residuei301 – 3011Phosphoserine4 Publications
    Modified residuei327 – 3271Phosphoserine2 Publications

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ8WUB8.
    PaxDbiQ8WUB8.
    PRIDEiQ8WUB8.

    PTM databases

    PhosphoSiteiQ8WUB8.

    Expressioni

    Gene expression databases

    BgeeiQ8WUB8.
    CleanExiHS_PHF10.
    GenevestigatoriQ8WUB8.

    Organism-specific databases

    HPAiHPA055649.

    Interactioni

    Subunit structurei

    Component of neural progenitors-specific chromatin remodeling complex (npBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A and actin. Interacts with ACTL6A/BAF53A, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A and PBRM1/BAF180 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi120562. 21 interactions.
    IntActiQ8WUB8. 10 interactions.
    MINTiMINT-1373208.
    STRINGi9606.ENSP00000341805.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8WUB8.
    SMRiQ8WUB8. Positions 376-479.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni89 – 295207SAYAdd
    BLAST
    Regioni89 – 18597Essential to induce neural progenitor proliferationBy similarityAdd
    BLAST
    Regioni292 – 33443Essential to induce neural progenitor proliferationBy similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the SAYP family.Curated
    Contains 2 PHD-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri379 – 43658PHD-type 1; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri438 – 48144PHD-type 2; degeneratePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG279558.
    HOGENOMiHOG000286026.
    HOVERGENiHBG053581.
    InParanoidiQ8WUB8.
    OMAiEYKWPPD.
    OrthoDBiEOG72VH60.
    PhylomeDBiQ8WUB8.
    TreeFamiTF318971.

    Family and domain databases

    Gene3Di3.30.40.10. 2 hits.
    InterProiIPR011011. Znf_FYVE_PHD.
    IPR001965. Znf_PHD.
    IPR019787. Znf_PHD-finger.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PfamiPF00628. PHD. 1 hit.
    [Graphical view]
    SMARTiSM00249. PHD. 2 hits.
    [Graphical view]
    SUPFAMiSSF57903. SSF57903. 2 hits.
    PROSITEiPS01359. ZF_PHD_1. 1 hit.
    PS50016. ZF_PHD_2. 2 hits.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8WUB8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAAAGPGAA LSPRPCDSDP ATPGAQSPKD DNEDNSNDGT QPSKRRRMGS    50
    GDSSRSCETS SQDLGFSYYP AENLIEYKWP PDETGEYYML QEQVSEYLGV 100
    TSFKRKYPDL ERRDLSHKEK LYLRELNVIT ETQCTLGLTA LRSDEVIDLM 150
    IKEYPAKHAE YSVILQEKER QRITDHYKEY SQMQQQNTQK VEASKVPEYI 200
    KKAAKKAAEF NSNLNRERME ERRAYFDLQT HVIQVPQGKY KVLPTERTKV 250
    SSYPVALIPG QFQEYYKRYS PDELRYLPLN TALYEPPLDP ELPALDSDGD 300
    SDDGEDGRGD EKRKNKGTSD SSSGNVSEGE SPPDSQEDSF QGRQKSKDKA 350
    ATPRKDGPKR SVLSKSVPGY KPKVIPNAIC GICLKGKESN KKGKAESLIH 400
    CSQCENSGHP SCLDMTMELV SMIKTYPWQC MECKTCIICG QPHHEEEMMF 450
    CDMCDRGYHT FCVGLGAIPS GRWICDCCQR APPTPRKVGR RGKNSKEG 498
    Length:498
    Mass (Da):56,051
    Last modified:May 18, 2010 - v3
    Checksum:i05EFDABD2000C2B7
    GO
    Isoform 2 (identifier: Q8WUB8-2) [UniParc]FASTAAdd to Basket

    Also known as: B

    The sequence of this isoform differs from the canonical sequence as follows:
         109-110: Missing.

    Show »
    Length:496
    Mass (Da):55,823
    Checksum:i6D4EAF7B86CA38C1
    GO
    Isoform 3 (identifier: Q8WUB8-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-47: Missing.

    Show »
    Length:451
    Mass (Da):51,290
    Checksum:i8F3DE3D2A999E8A0
    GO

    Sequence cautioni

    The sequence AAH20954.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence AAI10324.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAA91934.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAD96332.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence CAG33554.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence AAK27451.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAI12316.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti126 – 1261L → P in AAK27451. (PubMed:11827455)Curated
    Sequence conflicti246 – 2461E → G in AAK27451. (PubMed:11827455)Curated
    Sequence conflicti275 – 2751R → W in AAK27451. (PubMed:11827455)Curated
    Sequence conflicti286 – 2872PP → AT in AAK27451. (PubMed:11827455)Curated
    Sequence conflicti325 – 3251N → K in AAK27451. (PubMed:11827455)Curated
    Sequence conflicti332 – 3321P → S in AAK27451. (PubMed:11827455)Curated
    Sequence conflicti357 – 3571G → A in AAK27451. (PubMed:11827455)Curated
    Sequence conflicti365 – 3651K → N in AAK27451. (PubMed:11827455)Curated
    Sequence conflicti422 – 4221M → T in BAD96332. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 4747Missing in isoform 3. 1 PublicationVSP_039090Add
    BLAST
    Alternative sequencei109 – 1102Missing in isoform 2. 1 PublicationVSP_013440

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL513547 Genomic DNA. Translation: CAI12316.1. Sequence problems.
    BC020954 mRNA. Translation: AAH20954.1. Different initiation.
    BC110323 mRNA. Translation: AAI10324.1. Different initiation.
    AF338735 Genomic DNA. Translation: AAK27451.1. Sequence problems.
    AK001837 mRNA. Translation: BAA91934.1. Different initiation.
    CR457273 mRNA. Translation: CAG33554.1. Different initiation.
    AK222612 mRNA. Translation: BAD96332.1. Different initiation.
    CCDSiCCDS5308.2. [Q8WUB8-1]
    CCDS5309.2. [Q8WUB8-2]
    RefSeqiNP_060758.2. NM_018288.3. [Q8WUB8-1]
    NP_579866.2. NM_133325.2. [Q8WUB8-2]
    UniGeneiHs.435933.

    Genome annotation databases

    EnsembliENST00000339209; ENSP00000341805; ENSG00000130024. [Q8WUB8-1]
    ENST00000366780; ENSP00000355743; ENSG00000130024. [Q8WUB8-2]
    GeneIDi55274.
    KEGGihsa:55274.
    UCSCiuc011egy.2. human. [Q8WUB8-1]
    uc011egz.2. human. [Q8WUB8-2]

    Polymorphism databases

    DMDMi296439276.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL513547 Genomic DNA. Translation: CAI12316.1 . Sequence problems.
    BC020954 mRNA. Translation: AAH20954.1 . Different initiation.
    BC110323 mRNA. Translation: AAI10324.1 . Different initiation.
    AF338735 Genomic DNA. Translation: AAK27451.1 . Sequence problems.
    AK001837 mRNA. Translation: BAA91934.1 . Different initiation.
    CR457273 mRNA. Translation: CAG33554.1 . Different initiation.
    AK222612 mRNA. Translation: BAD96332.1 . Different initiation.
    CCDSi CCDS5308.2. [Q8WUB8-1 ]
    CCDS5309.2. [Q8WUB8-2 ]
    RefSeqi NP_060758.2. NM_018288.3. [Q8WUB8-1 ]
    NP_579866.2. NM_133325.2. [Q8WUB8-2 ]
    UniGenei Hs.435933.

    3D structure databases

    ProteinModelPortali Q8WUB8.
    SMRi Q8WUB8. Positions 376-479.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120562. 21 interactions.
    IntActi Q8WUB8. 10 interactions.
    MINTi MINT-1373208.
    STRINGi 9606.ENSP00000341805.

    PTM databases

    PhosphoSitei Q8WUB8.

    Polymorphism databases

    DMDMi 296439276.

    Proteomic databases

    MaxQBi Q8WUB8.
    PaxDbi Q8WUB8.
    PRIDEi Q8WUB8.

    Protocols and materials databases

    DNASUi 55274.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000339209 ; ENSP00000341805 ; ENSG00000130024 . [Q8WUB8-1 ]
    ENST00000366780 ; ENSP00000355743 ; ENSG00000130024 . [Q8WUB8-2 ]
    GeneIDi 55274.
    KEGGi hsa:55274.
    UCSCi uc011egy.2. human. [Q8WUB8-1 ]
    uc011egz.2. human. [Q8WUB8-2 ]

    Organism-specific databases

    CTDi 55274.
    GeneCardsi GC06M170104.
    HGNCi HGNC:18250. PHF10.
    HPAi HPA055649.
    MIMi 613069. gene.
    neXtProti NX_Q8WUB8.
    PharmGKBi PA134972675.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG279558.
    HOGENOMi HOG000286026.
    HOVERGENi HBG053581.
    InParanoidi Q8WUB8.
    OMAi EYKWPPD.
    OrthoDBi EOG72VH60.
    PhylomeDBi Q8WUB8.
    TreeFami TF318971.

    Miscellaneous databases

    GeneWikii PHF10.
    GenomeRNAii 55274.
    NextBioi 59399.
    PROi Q8WUB8.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8WUB8.
    CleanExi HS_PHF10.
    Genevestigatori Q8WUB8.

    Family and domain databases

    Gene3Di 3.30.40.10. 2 hits.
    InterProi IPR011011. Znf_FYVE_PHD.
    IPR001965. Znf_PHD.
    IPR019787. Znf_PHD-finger.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    Pfami PF00628. PHD. 1 hit.
    [Graphical view ]
    SMARTi SM00249. PHD. 2 hits.
    [Graphical view ]
    SUPFAMi SSF57903. SSF57903. 2 hits.
    PROSITEi PS01359. ZF_PHD_1. 1 hit.
    PS50016. ZF_PHD_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "PHF10 is required for cell proliferation in normal and SV40-immortalized human fibroblast cells."
      Banga S.S., Peng L., Dasgupta T., Palejwala V., Ozer H.L.
      Cytogenet. Genome Res. 126:227-242(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
    2. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Colon and Skin.
    4. "Physical and genetic characterization reveals a pseudogene, an evolutionary junction, and unstable loci in distal Xq28."
      Aradhya S., Woffendin H., Bonnen P., Heiss N.S., Yamagata T., Esposito T., Bardaro T., Poustka A., D'Urso M., Kenwrick S., Nelson D.L.
      Genomics 79:31-40(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 73-498 (ISOFORM 1), ALTERNATIVE SPLICING.
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 87-498 (ISOFORM 1).
      Tissue: Placenta.
    6. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 89-498 (ISOFORM 1).
    7. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 89-498 (ISOFORM 1).
      Tissue: Artery smooth muscle.
    8. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
      J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-270; SER-297 AND SER-301, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-297; SER-301 AND SER-327, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-12; SER-270; SER-297 AND SER-301, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-36; SER-50; SER-297; SER-301 AND SER-327, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiPHF10_HUMAN
    AccessioniPrimary (citable) accession number: Q8WUB8
    Secondary accession number(s): Q2YDA3
    , Q53HG8, Q9BXD2, Q9NV26
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 110 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    It is uncertain whether Met-1 or Met-89 is the initiator.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3