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Protein

PHD finger protein 10

Gene

PHF10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in transcription activity regulation by chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri379 – 43658PHD-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri438 – 48144PHD-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. zinc ion binding Source: InterPro

GO - Biological processi

  1. nervous system development Source: UniProtKB-KW
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Neurogenesis, Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
PHD finger protein 10
Alternative name(s):
BRG1-associated factor 45a
Short name:
BAF45a
XAP135
Gene namesi
Name:PHF10
Synonyms:BAF45A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:18250. PHF10.

Subcellular locationi

  1. Nucleus By similarity

GO - Cellular componenti

  1. npBAF complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134972675.

Polymorphism and mutation databases

BioMutaiPHF10.
DMDMi296439276.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 498497PHD finger protein 10PRO_0000059297Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication
Modified residuei12 – 121Phosphoserine1 Publication
Modified residuei36 – 361Phosphoserine1 Publication
Modified residuei50 – 501Phosphoserine1 Publication
Modified residuei270 – 2701Phosphoserine2 Publications
Modified residuei297 – 2971Phosphoserine5 Publications
Modified residuei301 – 3011Phosphoserine5 Publications
Modified residuei327 – 3271Phosphoserine2 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ8WUB8.
PaxDbiQ8WUB8.
PRIDEiQ8WUB8.

PTM databases

PhosphoSiteiQ8WUB8.

Expressioni

Gene expression databases

BgeeiQ8WUB8.
CleanExiHS_PHF10.
ExpressionAtlasiQ8WUB8. baseline and differential.
GenevestigatoriQ8WUB8.

Organism-specific databases

HPAiHPA055649.

Interactioni

Subunit structurei

Component of neural progenitors-specific chromatin remodeling complex (npBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A and actin. Interacts with ACTL6A/BAF53A, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A and PBRM1/BAF180 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
L3MBTL2Q969R53EBI-10276329,EBI-739909

Protein-protein interaction databases

BioGridi120562. 25 interactions.
IntActiQ8WUB8. 10 interactions.
MINTiMINT-1373208.
STRINGi9606.ENSP00000341805.

Structurei

3D structure databases

ProteinModelPortaliQ8WUB8.
SMRiQ8WUB8. Positions 376-479.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni89 – 295207SAYAdd
BLAST
Regioni89 – 18597Essential to induce neural progenitor proliferationBy similarityAdd
BLAST
Regioni292 – 33443Essential to induce neural progenitor proliferationBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the SAYP family.Curated
Contains 2 PHD-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri379 – 43658PHD-type 1; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri438 – 48144PHD-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG279558.
GeneTreeiENSGT00530000063194.
HOGENOMiHOG000286026.
HOVERGENiHBG053581.
InParanoidiQ8WUB8.
OMAiEYKWPPD.
OrthoDBiEOG72VH60.
PhylomeDBiQ8WUB8.
TreeFamiTF318971.

Family and domain databases

Gene3Di3.30.40.10. 2 hits.
InterProiIPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00628. PHD. 1 hit.
[Graphical view]
SMARTiSM00249. PHD. 2 hits.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 2 hits.
PROSITEiPS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WUB8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAAGPGAA LSPRPCDSDP ATPGAQSPKD DNEDNSNDGT QPSKRRRMGS
60 70 80 90 100
GDSSRSCETS SQDLGFSYYP AENLIEYKWP PDETGEYYML QEQVSEYLGV
110 120 130 140 150
TSFKRKYPDL ERRDLSHKEK LYLRELNVIT ETQCTLGLTA LRSDEVIDLM
160 170 180 190 200
IKEYPAKHAE YSVILQEKER QRITDHYKEY SQMQQQNTQK VEASKVPEYI
210 220 230 240 250
KKAAKKAAEF NSNLNRERME ERRAYFDLQT HVIQVPQGKY KVLPTERTKV
260 270 280 290 300
SSYPVALIPG QFQEYYKRYS PDELRYLPLN TALYEPPLDP ELPALDSDGD
310 320 330 340 350
SDDGEDGRGD EKRKNKGTSD SSSGNVSEGE SPPDSQEDSF QGRQKSKDKA
360 370 380 390 400
ATPRKDGPKR SVLSKSVPGY KPKVIPNAIC GICLKGKESN KKGKAESLIH
410 420 430 440 450
CSQCENSGHP SCLDMTMELV SMIKTYPWQC MECKTCIICG QPHHEEEMMF
460 470 480 490
CDMCDRGYHT FCVGLGAIPS GRWICDCCQR APPTPRKVGR RGKNSKEG
Length:498
Mass (Da):56,051
Last modified:May 18, 2010 - v3
Checksum:i05EFDABD2000C2B7
GO
Isoform 2 (identifier: Q8WUB8-2) [UniParc]FASTAAdd to basket

Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     109-110: Missing.

Show »
Length:496
Mass (Da):55,823
Checksum:i6D4EAF7B86CA38C1
GO
Isoform 3 (identifier: Q8WUB8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-47: Missing.

Show »
Length:451
Mass (Da):51,290
Checksum:i8F3DE3D2A999E8A0
GO

Sequence cautioni

The sequence AAH20954.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI10324.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAK27451.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence BAA91934.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAD96332.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAG33554.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAI12316.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti126 – 1261L → P in AAK27451 (PubMed:11827455).Curated
Sequence conflicti246 – 2461E → G in AAK27451 (PubMed:11827455).Curated
Sequence conflicti275 – 2751R → W in AAK27451 (PubMed:11827455).Curated
Sequence conflicti286 – 2872PP → AT in AAK27451 (PubMed:11827455).Curated
Sequence conflicti325 – 3251N → K in AAK27451 (PubMed:11827455).Curated
Sequence conflicti332 – 3321P → S in AAK27451 (PubMed:11827455).Curated
Sequence conflicti357 – 3571G → A in AAK27451 (PubMed:11827455).Curated
Sequence conflicti365 – 3651K → N in AAK27451 (PubMed:11827455).Curated
Sequence conflicti422 – 4221M → T in BAD96332 (Ref. 7) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4747Missing in isoform 3. 1 PublicationVSP_039090Add
BLAST
Alternative sequencei109 – 1102Missing in isoform 2. 1 PublicationVSP_013440

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL513547 Genomic DNA. Translation: CAI12316.1. Sequence problems.
BC020954 mRNA. Translation: AAH20954.1. Different initiation.
BC110323 mRNA. Translation: AAI10324.1. Different initiation.
AF338735 Genomic DNA. Translation: AAK27451.1. Sequence problems.
AK001837 mRNA. Translation: BAA91934.1. Different initiation.
CR457273 mRNA. Translation: CAG33554.1. Different initiation.
AK222612 mRNA. Translation: BAD96332.1. Different initiation.
CCDSiCCDS5308.2. [Q8WUB8-1]
CCDS5309.2. [Q8WUB8-2]
RefSeqiNP_060758.2. NM_018288.3. [Q8WUB8-1]
NP_579866.2. NM_133325.2. [Q8WUB8-2]
UniGeneiHs.435933.

Genome annotation databases

EnsembliENST00000339209; ENSP00000341805; ENSG00000130024. [Q8WUB8-1]
ENST00000366780; ENSP00000355743; ENSG00000130024. [Q8WUB8-2]
ENST00000621772; ENSP00000484117; ENSG00000130024. [Q8WUB8-3]
GeneIDi55274.
KEGGihsa:55274.
UCSCiuc011egy.2. human. [Q8WUB8-1]
uc011egz.2. human. [Q8WUB8-2]

Polymorphism and mutation databases

BioMutaiPHF10.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL513547 Genomic DNA. Translation: CAI12316.1. Sequence problems.
BC020954 mRNA. Translation: AAH20954.1. Different initiation.
BC110323 mRNA. Translation: AAI10324.1. Different initiation.
AF338735 Genomic DNA. Translation: AAK27451.1. Sequence problems.
AK001837 mRNA. Translation: BAA91934.1. Different initiation.
CR457273 mRNA. Translation: CAG33554.1. Different initiation.
AK222612 mRNA. Translation: BAD96332.1. Different initiation.
CCDSiCCDS5308.2. [Q8WUB8-1]
CCDS5309.2. [Q8WUB8-2]
RefSeqiNP_060758.2. NM_018288.3. [Q8WUB8-1]
NP_579866.2. NM_133325.2. [Q8WUB8-2]
UniGeneiHs.435933.

3D structure databases

ProteinModelPortaliQ8WUB8.
SMRiQ8WUB8. Positions 376-479.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120562. 25 interactions.
IntActiQ8WUB8. 10 interactions.
MINTiMINT-1373208.
STRINGi9606.ENSP00000341805.

PTM databases

PhosphoSiteiQ8WUB8.

Polymorphism and mutation databases

BioMutaiPHF10.
DMDMi296439276.

Proteomic databases

MaxQBiQ8WUB8.
PaxDbiQ8WUB8.
PRIDEiQ8WUB8.

Protocols and materials databases

DNASUi55274.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339209; ENSP00000341805; ENSG00000130024. [Q8WUB8-1]
ENST00000366780; ENSP00000355743; ENSG00000130024. [Q8WUB8-2]
ENST00000621772; ENSP00000484117; ENSG00000130024. [Q8WUB8-3]
GeneIDi55274.
KEGGihsa:55274.
UCSCiuc011egy.2. human. [Q8WUB8-1]
uc011egz.2. human. [Q8WUB8-2]

Organism-specific databases

CTDi55274.
GeneCardsiGC06M170104.
HGNCiHGNC:18250. PHF10.
HPAiHPA055649.
MIMi613069. gene.
neXtProtiNX_Q8WUB8.
PharmGKBiPA134972675.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG279558.
GeneTreeiENSGT00530000063194.
HOGENOMiHOG000286026.
HOVERGENiHBG053581.
InParanoidiQ8WUB8.
OMAiEYKWPPD.
OrthoDBiEOG72VH60.
PhylomeDBiQ8WUB8.
TreeFamiTF318971.

Miscellaneous databases

GeneWikiiPHF10.
GenomeRNAii55274.
NextBioi59399.
PROiQ8WUB8.
SOURCEiSearch...

Gene expression databases

BgeeiQ8WUB8.
CleanExiHS_PHF10.
ExpressionAtlasiQ8WUB8. baseline and differential.
GenevestigatoriQ8WUB8.

Family and domain databases

Gene3Di3.30.40.10. 2 hits.
InterProiIPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00628. PHD. 1 hit.
[Graphical view]
SMARTiSM00249. PHD. 2 hits.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 2 hits.
PROSITEiPS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "PHF10 is required for cell proliferation in normal and SV40-immortalized human fibroblast cells."
    Banga S.S., Peng L., Dasgupta T., Palejwala V., Ozer H.L.
    Cytogenet. Genome Res. 126:227-242(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Colon and Skin.
  4. "Physical and genetic characterization reveals a pseudogene, an evolutionary junction, and unstable loci in distal Xq28."
    Aradhya S., Woffendin H., Bonnen P., Heiss N.S., Yamagata T., Esposito T., Bardaro T., Poustka A., D'Urso M., Kenwrick S., Nelson D.L.
    Genomics 79:31-40(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 73-498 (ISOFORM 1), ALTERNATIVE SPLICING.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 87-498 (ISOFORM 1).
    Tissue: Placenta.
  6. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 89-498 (ISOFORM 1).
  7. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 89-498 (ISOFORM 1).
    Tissue: Artery smooth muscle.
  8. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-270; SER-297 AND SER-301, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-297; SER-301 AND SER-327, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-12; SER-270; SER-297 AND SER-301, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-36; SER-50; SER-297; SER-301 AND SER-327, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-297 AND SER-301, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiPHF10_HUMAN
AccessioniPrimary (citable) accession number: Q8WUB8
Secondary accession number(s): Q2YDA3
, Q53HG8, Q9BXD2, Q9NV26
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: May 18, 2010
Last modified: April 29, 2015
This is version 114 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-89 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.