Q8WUB2 (F216A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein FAM216A

Gene names

Name:	FAM216A
Synonyms:	C12orf24

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	273 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities	Belongs to the FAM216 family.
Caution	It is uncertain whether Met-1 or Met-18 is the initiator.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 273	273	Protein FAM216A		PRO_0000288861
Natural variations
	Natural variant	225	1	R → G. Corresponds to variant rs17188964 [ dbSNP | Ensembl ].		VAR_032513
Experimental info
	Sequence conflict	200	1	R → W in AAB50215. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q8WUB2 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: B06EF30057AB8586	FASTA	273	30,792
	10 20 30 40 50 60 MLGQLLPHTA RGLGAAEMPG QGPGSDWTER SSSAEPPAVA GTEGGGGGSA GYSCYQNSKG 70 80 90 100 110 120 SDRIKDGYKV NSHIAKLQEL WKTPQNQTIH LSKSMMEASF FKHPDLTTGQ KRYLCSIAKI 130 140 150 160 170 180 YNANYLKMLM KRQYMHVLQH SSQKPGVLTH HRSRLSSRYS QKQHYPCTTW RHQLEREDSG 190 200 210 220 230 240 SSDIAAASAP EMLIQHSLWR PVRNKEGIKT GYASKTRCKS LKIFRRPRKL FMQTVSSDDS 250 260 270 ESHMSEEKKE EDLLNNFMQS MSIEEQGEHL MLT

References

[1]	"Large-scale concatenation cDNA sequencing." Yu W., Andersson B., Worley K.C., Muzny D.M., Ding Y., Liu W., Ricafrente J.Y., Wentland M.A., Lennon G., Gibbs R.A. Genome Res. 7:353-358(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[2]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"The finished DNA sequence of human chromosome 12." Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A. Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U79274 mRNA. Translation: AAB50215.1. CR457001 mRNA. Translation: CAG33282.1. AC002350 Genomic DNA. No translation available. CH471054 Genomic DNA. Translation: EAW97917.1. BC020967 mRNA. Translation: AAH20967.1.
IPI	IPI00291108.
RefSeq	NP_037432.2. NM_013300.2.
UniGene	Hs.436618.
3D structure databases
ProteinModelPortal	Q8WUB2.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000366901.
PTM databases
PhosphoSite	Q8WUB2.
Polymorphism databases
DMDM	74730685.
Proteomic databases
PaxDb	Q8WUB2.
PRIDE	Q8WUB2.
Protocols and materials databases
DNASU	29902.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000377673; ENSP00000366901; ENSG00000204856.
GeneID	29902.
KEGG	hsa:29902.
UCSC	uc001tqu.4. human.
Organism-specific databases
CTD	29902.
GeneCards	GC12P110907.
HGNC	HGNC:30180. FAM216A.
HPA	HPA038286. HPA038287.
neXtProt	NX_Q8WUB2.
PharmGKB	PA128395781.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG47451.
HOGENOM	HOG000111755.
HOVERGEN	HBG102671.
InParanoid	Q8WUB2.
OMA	HYPCTTW.
OrthoDB	EOG4RNB97.
Gene expression databases
ArrayExpress	Q8WUB2.
Bgee	Q8WUB2.
CleanEx	HS_C12orf24.
Genevestigator	Q8WUB2.
Family and domain databases
ProtoNet	Search...
Other
GenomeRNAi	29902.
NextBio	52470.

Entry information

Entry name

F216A_HUMAN

Accession

Primary (citable) accession number: Q8WUB2
Secondary accession number(s): A6NH30, Q99776

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 29, 2007
Last sequence update:	March 1, 2002
Last modified:	May 1, 2013
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.