Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q8WUB2 (F216A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein FAM216A
Gene names
Name:FAM216A
Synonyms:C12orf24
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length273 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the FAM216 family.

Caution

It is uncertain whether Met-1 or Met-18 is the initiator.

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 273273Protein FAM216A
PRO_0000288861

Natural variations

Natural variant2251R → G.
Corresponds to variant rs17188964 [ dbSNP | Ensembl ].
VAR_032513

Experimental info

Sequence conflict2001R → W in AAB50215. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q8WUB2 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: B06EF30057AB8586

FASTA27330,792
        10         20         30         40         50         60 
MLGQLLPHTA RGLGAAEMPG QGPGSDWTER SSSAEPPAVA GTEGGGGGSA GYSCYQNSKG 

        70         80         90        100        110        120 
SDRIKDGYKV NSHIAKLQEL WKTPQNQTIH LSKSMMEASF FKHPDLTTGQ KRYLCSIAKI 

       130        140        150        160        170        180 
YNANYLKMLM KRQYMHVLQH SSQKPGVLTH HRSRLSSRYS QKQHYPCTTW RHQLEREDSG 

       190        200        210        220        230        240 
SSDIAAASAP EMLIQHSLWR PVRNKEGIKT GYASKTRCKS LKIFRRPRKL FMQTVSSDDS 

       250        260        270 
ESHMSEEKKE EDLLNNFMQS MSIEEQGEHL MLT 

« Hide

References

[1]"Large-scale concatenation cDNA sequencing."
Yu W., Andersson B., Worley K.C., Muzny D.M., Ding Y., Liu W., Ricafrente J.Y., Wentland M.A., Lennon G., Gibbs R.A.
Genome Res. 7:353-358(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[2]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"The finished DNA sequence of human chromosome 12."
Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. expand/collapse author list , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Colon.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U79274 mRNA. Translation: AAB50215.1.
CR457001 mRNA. Translation: CAG33282.1.
AC002350 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW97917.1.
BC020967 mRNA. Translation: AAH20967.1.
CCDSCCDS31899.1.
RefSeqNP_037432.2. NM_013300.2.
UniGeneHs.436618.

3D structure databases

ProteinModelPortalQ8WUB2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid118951. 1 interaction.
STRING9606.ENSP00000366901.

PTM databases

PhosphoSiteQ8WUB2.

Polymorphism databases

DMDM74730685.

Proteomic databases

PaxDbQ8WUB2.
PRIDEQ8WUB2.

Protocols and materials databases

DNASU29902.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000377673; ENSP00000366901; ENSG00000204856.
GeneID29902.
KEGGhsa:29902.
UCSCuc001tqu.4. human.

Organism-specific databases

CTD29902.
GeneCardsGC12P110907.
HGNCHGNC:30180. FAM216A.
HPAHPA038286.
HPA038287.
neXtProtNX_Q8WUB2.
PharmGKBPA128395781.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG47451.
HOGENOMHOG000111755.
HOVERGENHBG102671.
InParanoidQ8WUB2.
OMAHYPCTTW.
OrthoDBEOG7DC257.
PhylomeDBQ8WUB2.
TreeFamTF337546.

Gene expression databases

ArrayExpressQ8WUB2.
BgeeQ8WUB2.
CleanExHS_C12orf24.
GenevestigatorQ8WUB2.

Family and domain databases

InterProIPR029373. FAM216.
[Graphical view]
PfamPF15107. FAM216B. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi29902.
NextBio52470.
PROQ8WUB2.

Entry information

Entry nameF216A_HUMAN
AccessionPrimary (citable) accession number: Q8WUB2
Secondary accession number(s): A6NH30, Q99776
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: March 1, 2002
Last modified: July 9, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM