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Q8WUB2

- F216A_HUMAN

UniProt

Q8WUB2 - F216A_HUMAN

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Protein

Protein FAM216A

Gene

FAM216A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM216A
Gene namesi
Name:FAM216A
Synonyms:C12orf24
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:30180. FAM216A.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA128395781.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 273273Protein FAM216APRO_0000288861Add
BLAST

Proteomic databases

MaxQBiQ8WUB2.
PaxDbiQ8WUB2.
PRIDEiQ8WUB2.

PTM databases

PhosphoSiteiQ8WUB2.

Expressioni

Gene expression databases

BgeeiQ8WUB2.
CleanExiHS_C12orf24.
ExpressionAtlasiQ8WUB2. baseline and differential.
GenevestigatoriQ8WUB2.

Organism-specific databases

HPAiHPA038286.
HPA038287.

Interactioni

Protein-protein interaction databases

BioGridi118951. 2 interactions.
STRINGi9606.ENSP00000366901.

Structurei

3D structure databases

ProteinModelPortaliQ8WUB2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM216 family.Curated

Phylogenomic databases

eggNOGiNOG47451.
GeneTreeiENSGT00390000012966.
HOGENOMiHOG000111755.
HOVERGENiHBG102671.
InParanoidiQ8WUB2.
OMAiHYPCTTW.
OrthoDBiEOG7DC257.
PhylomeDBiQ8WUB2.
TreeFamiTF337546.

Family and domain databases

InterProiIPR029373. FAM216.
[Graphical view]
PfamiPF15107. FAM216B. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WUB2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLGQLLPHTA RGLGAAEMPG QGPGSDWTER SSSAEPPAVA GTEGGGGGSA
60 70 80 90 100
GYSCYQNSKG SDRIKDGYKV NSHIAKLQEL WKTPQNQTIH LSKSMMEASF
110 120 130 140 150
FKHPDLTTGQ KRYLCSIAKI YNANYLKMLM KRQYMHVLQH SSQKPGVLTH
160 170 180 190 200
HRSRLSSRYS QKQHYPCTTW RHQLEREDSG SSDIAAASAP EMLIQHSLWR
210 220 230 240 250
PVRNKEGIKT GYASKTRCKS LKIFRRPRKL FMQTVSSDDS ESHMSEEKKE
260 270
EDLLNNFMQS MSIEEQGEHL MLT
Length:273
Mass (Da):30,792
Last modified:March 1, 2002 - v1
Checksum:iB06EF30057AB8586
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti200 – 2001R → W in AAB50215. (PubMed:9110174)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti225 – 2251R → G.
Corresponds to variant rs17188964 [ dbSNP | Ensembl ].
VAR_032513

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U79274 mRNA. Translation: AAB50215.1.
CR457001 mRNA. Translation: CAG33282.1.
AC002350 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW97917.1.
BC020967 mRNA. Translation: AAH20967.1.
CCDSiCCDS31899.1.
RefSeqiNP_037432.2. NM_013300.2.
UniGeneiHs.436618.

Genome annotation databases

EnsembliENST00000377673; ENSP00000366901; ENSG00000204856.
GeneIDi29902.
KEGGihsa:29902.
UCSCiuc001tqu.4. human.

Polymorphism databases

DMDMi74730685.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U79274 mRNA. Translation: AAB50215.1 .
CR457001 mRNA. Translation: CAG33282.1 .
AC002350 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW97917.1 .
BC020967 mRNA. Translation: AAH20967.1 .
CCDSi CCDS31899.1.
RefSeqi NP_037432.2. NM_013300.2.
UniGenei Hs.436618.

3D structure databases

ProteinModelPortali Q8WUB2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 118951. 2 interactions.
STRINGi 9606.ENSP00000366901.

PTM databases

PhosphoSitei Q8WUB2.

Polymorphism databases

DMDMi 74730685.

Proteomic databases

MaxQBi Q8WUB2.
PaxDbi Q8WUB2.
PRIDEi Q8WUB2.

Protocols and materials databases

DNASUi 29902.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000377673 ; ENSP00000366901 ; ENSG00000204856 .
GeneIDi 29902.
KEGGi hsa:29902.
UCSCi uc001tqu.4. human.

Organism-specific databases

CTDi 29902.
GeneCardsi GC12P110907.
HGNCi HGNC:30180. FAM216A.
HPAi HPA038286.
HPA038287.
neXtProti NX_Q8WUB2.
PharmGKBi PA128395781.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG47451.
GeneTreei ENSGT00390000012966.
HOGENOMi HOG000111755.
HOVERGENi HBG102671.
InParanoidi Q8WUB2.
OMAi HYPCTTW.
OrthoDBi EOG7DC257.
PhylomeDBi Q8WUB2.
TreeFami TF337546.

Miscellaneous databases

GenomeRNAii 29902.
NextBioi 52470.
PROi Q8WUB2.

Gene expression databases

Bgeei Q8WUB2.
CleanExi HS_C12orf24.
ExpressionAtlasi Q8WUB2. baseline and differential.
Genevestigatori Q8WUB2.

Family and domain databases

InterProi IPR029373. FAM216.
[Graphical view ]
Pfami PF15107. FAM216B. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Large-scale concatenation cDNA sequencing."
    Yu W., Andersson B., Worley K.C., Muzny D.M., Ding Y., Liu W., Ricafrente J.Y., Wentland M.A., Lennon G., Gibbs R.A.
    Genome Res. 7:353-358(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon.

Entry informationi

Entry nameiF216A_HUMAN
AccessioniPrimary (citable) accession number: Q8WUB2
Secondary accession number(s): A6NH30, Q99776
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: March 1, 2002
Last modified: October 29, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-18 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3