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Protein

Tsukushin

Gene

TSKU

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Tsukushin
Short name:
Tsukushi
Alternative name(s):
E2-induced gene 4 protein
Leucine-rich repeat-containing protein 54
Gene namesi
Name:TSKU
Synonyms:E2IG4, LRRC54, TSK
ORF Names:UNQ850/PRO1788
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:28850. TSKU.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162407150.

Polymorphism and mutation databases

BioMutaiTSKU.
DMDMi116242832.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence analysisAdd
BLAST
Chaini17 – 353337TsukushinPRO_0000240407Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi74 – 741N-linked (GlcNAc...)Sequence analysis
Glycosylationi137 – 1371N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ8WUA8.
MaxQBiQ8WUA8.
PaxDbiQ8WUA8.
PeptideAtlasiQ8WUA8.
PRIDEiQ8WUA8.

PTM databases

iPTMnetiQ8WUA8.
PhosphoSiteiQ8WUA8.

Expressioni

Inductioni

By 17-beta-estradiol.

Gene expression databases

BgeeiENSG00000182704.
CleanExiHS_TSKU.
ExpressionAtlasiQ8WUA8. baseline and differential.
GenevisibleiQ8WUA8. HS.

Organism-specific databases

HPAiHPA008164.

Interactioni

Protein-protein interaction databases

BioGridi117468. 2 interactions.
IntActiQ8WUA8. 1 interaction.
MINTiMINT-1180605.
STRINGi9606.ENSP00000332668.

Structurei

3D structure databases

ProteinModelPortaliQ8WUA8.
SMRiQ8WUA8. Positions 18-338.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini17 – 5842LRRNTAdd
BLAST
Repeati59 – 8022LRR 1Add
BLAST
Repeati85 – 10622LRR 2Add
BLAST
Repeati109 – 13022LRR 3Add
BLAST
Repeati132 – 15322LRR 4Add
BLAST
Repeati159 – 17921LRR 5Add
BLAST
Repeati185 – 20622LRR 6Add
BLAST
Repeati207 – 22721LRR 7Add
BLAST
Repeati230 – 24920LRR 8Add
BLAST
Repeati255 – 27622LRR 9Add
BLAST
Repeati280 – 30122LRR 10Add
BLAST

Sequence similaritiesi

Contains 10 LRR (leucine-rich) repeats.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00390000016740.
HOGENOMiHOG000001578.
HOVERGENiHBG054643.
InParanoidiQ8WUA8.
KOiK08130.
OMAiPKLKWAG.
OrthoDBiEOG091G09WG.
PhylomeDBiQ8WUA8.
TreeFamiTF343079.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 8 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 8 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8WUA8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPWPLLLLLA VSGAQTTRPC FPGCQCEVET FGLFDSFSLT RVDCSGLGPH
60 70 80 90 100
IMPVPIPLDT AHLDLSSNRL EMVNESVLAG PGYTTLAGLD LSHNLLTSIS
110 120 130 140 150
PTAFSRLRYL ESLDLSHNGL TALPAESFTS SPLSDVNLSH NQLREVSVSA
160 170 180 190 200
FTTHSQGRAL HVDLSHNLIH RLVPHPTRAG LPAPTIQSLN LAWNRLHAVP
210 220 230 240 250
NLRDLPLRYL SLDGNPLAVI GPGAFAGLGG LTHLSLASLQ RLPELAPSGF
260 270 280 290 300
RELPGLQVLD LSGNPKLNWA GAEVFSGLSS LQELDLSGTN LVPLPEALLL
310 320 330 340 350
HLPALQSVSV GQDVRCRRLV REGTYPRRPG SSPKVALHCV DTRDSAARGP

TIL
Length:353
Mass (Da):37,807
Last modified:October 17, 2006 - v3
Checksum:i80F073221B8A38A5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti336 – 3361A → P in AAQ88683 (PubMed:12975309).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti208 – 2081R → C.
Corresponds to variant rs3740772 [ dbSNP | Ensembl ].
VAR_028725
Natural varianti248 – 2481S → N.
Corresponds to variant rs11236938 [ dbSNP | Ensembl ].
VAR_028726
Natural varianti308 – 3081V → I.
Corresponds to variant rs3740771 [ dbSNP | Ensembl ].
VAR_028727
Natural varianti344 – 3441D → E.5 Publications
Corresponds to variant rs1149621 [ dbSNP | Ensembl ].
VAR_026726

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF191019 mRNA. Translation: AAF09483.1.
AY358317 mRNA. Translation: AAQ88683.1.
BT007440 mRNA. Translation: AAP36108.1.
AK075476 mRNA. Translation: BAG52149.1.
BC020975 mRNA. Translation: AAH20975.1.
AL110276 mRNA. Translation: CAB53711.1.
CCDSiCCDS8246.1.
PIRiT14791.
RefSeqiNP_001245139.1. NM_001258210.1.
NP_001305406.1. NM_001318477.1.
NP_001305407.1. NM_001318478.1.
NP_001305408.1. NM_001318479.1.
NP_056331.2. NM_015516.3.
UniGeneiHs.8361.

Genome annotation databases

EnsembliENST00000333090; ENSP00000332668; ENSG00000182704.
ENST00000527881; ENSP00000434847; ENSG00000182704.
ENST00000612930; ENSP00000482145; ENSG00000182704.
GeneIDi25987.
KEGGihsa:25987.
UCSCiuc001oxt.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF191019 mRNA. Translation: AAF09483.1.
AY358317 mRNA. Translation: AAQ88683.1.
BT007440 mRNA. Translation: AAP36108.1.
AK075476 mRNA. Translation: BAG52149.1.
BC020975 mRNA. Translation: AAH20975.1.
AL110276 mRNA. Translation: CAB53711.1.
CCDSiCCDS8246.1.
PIRiT14791.
RefSeqiNP_001245139.1. NM_001258210.1.
NP_001305406.1. NM_001318477.1.
NP_001305407.1. NM_001318478.1.
NP_001305408.1. NM_001318479.1.
NP_056331.2. NM_015516.3.
UniGeneiHs.8361.

3D structure databases

ProteinModelPortaliQ8WUA8.
SMRiQ8WUA8. Positions 18-338.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117468. 2 interactions.
IntActiQ8WUA8. 1 interaction.
MINTiMINT-1180605.
STRINGi9606.ENSP00000332668.

PTM databases

iPTMnetiQ8WUA8.
PhosphoSiteiQ8WUA8.

Polymorphism and mutation databases

BioMutaiTSKU.
DMDMi116242832.

Proteomic databases

EPDiQ8WUA8.
MaxQBiQ8WUA8.
PaxDbiQ8WUA8.
PeptideAtlasiQ8WUA8.
PRIDEiQ8WUA8.

Protocols and materials databases

DNASUi25987.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000333090; ENSP00000332668; ENSG00000182704.
ENST00000527881; ENSP00000434847; ENSG00000182704.
ENST00000612930; ENSP00000482145; ENSG00000182704.
GeneIDi25987.
KEGGihsa:25987.
UCSCiuc001oxt.4. human.

Organism-specific databases

CTDi25987.
GeneCardsiTSKU.
HGNCiHGNC:28850. TSKU.
HPAiHPA008164.
MIMi608015. gene.
neXtProtiNX_Q8WUA8.
PharmGKBiPA162407150.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00390000016740.
HOGENOMiHOG000001578.
HOVERGENiHBG054643.
InParanoidiQ8WUA8.
KOiK08130.
OMAiPKLKWAG.
OrthoDBiEOG091G09WG.
PhylomeDBiQ8WUA8.
TreeFamiTF343079.

Miscellaneous databases

ChiTaRSiTSKU. human.
GenomeRNAii25987.
PROiQ8WUA8.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000182704.
CleanExiHS_TSKU.
ExpressionAtlasiQ8WUA8. baseline and differential.
GenevisibleiQ8WUA8. HS.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 8 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 8 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTSK_HUMAN
AccessioniPrimary (citable) accession number: Q8WUA8
Secondary accession number(s): B3KQT7
, Q6UXK1, Q9UG10, Q9UJX9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: October 17, 2006
Last modified: September 7, 2016
This is version 122 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.