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Q8WUA4

- TF3C2_HUMAN

UniProt

Q8WUA4 - TF3C2_HUMAN

Protein

General transcription factor 3C polypeptide 2

Gene

GTF3C2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 2 (07 Jun 2004)
      Previous versions | rss
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    Functioni

    Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. May play a direct role in stabilizing interactions of TFIIIC2 with TFIIIC1.

    GO - Biological processi

    1. 5S class rRNA transcription from RNA polymerase III type 1 promoter Source: HGNC
    2. gene expression Source: Reactome
    3. transcription, DNA-templated Source: HGNC
    4. transcription from RNA polymerase III promoter Source: HGNC
    5. tRNA transcription from RNA polymerase III promoter Source: HGNC

    Keywords - Biological processi

    Transcription

    Enzyme and pathway databases

    ReactomeiREACT_1036. RNA Polymerase III Transcription Initiation From Type 2 Promoter.
    REACT_22339. RNA Polymerase III Abortive And Retractive Initiation.
    REACT_347. RNA Polymerase III Transcription Initiation From Type 1 Promoter.
    SignaLinkiQ8WUA4.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    General transcription factor 3C polypeptide 2
    Alternative name(s):
    TF3C-beta
    Transcription factor IIIC 110 kDa subunit
    Short name:
    TFIIIC 110 kDa subunit
    Short name:
    TFIIIC110
    Transcription factor IIIC subunit beta
    Gene namesi
    Name:GTF3C2
    Synonyms:KIAA0011
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:4665. GTF3C2.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleoplasm Source: Reactome
    2. transcription factor TFIIIC complex Source: HGNC

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29053.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 911911General transcription factor 3C polypeptide 2PRO_0000050985Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei63 – 631Phosphoserine1 Publication
    Modified residuei132 – 1321Phosphoserine1 Publication
    Modified residuei165 – 1651Phosphoserine1 Publication
    Modified residuei167 – 1671Phosphoserine3 Publications
    Modified residuei220 – 2201Phosphoserine1 Publication
    Modified residuei871 – 8711Phosphoserine1 Publication
    Modified residuei892 – 8921Phosphoserine2 Publications
    Modified residuei893 – 8931Phosphoserine1 Publication
    Modified residuei895 – 8951Phosphothreonine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8WUA4.
    PaxDbiQ8WUA4.
    PRIDEiQ8WUA4.

    PTM databases

    PhosphoSiteiQ8WUA4.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8WUA4.
    BgeeiQ8WUA4.
    CleanExiHS_GTF3C2.
    GenevestigatoriQ8WUA4.

    Organism-specific databases

    HPAiHPA035836.

    Interactioni

    Subunit structurei

    Part of the TFIIIC subcomplex TFIIIC2, consisting of six subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5 and GTF3C6.

    Protein-protein interaction databases

    BioGridi109231. 19 interactions.
    DIPiDIP-38213N.
    IntActiQ8WUA4. 8 interactions.
    MINTiMINT-4535724.
    STRINGi9606.ENSP00000264720.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8WUA4.
    SMRiQ8WUA4. Positions 834-869.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati461 – 51757WD 1Add
    BLAST
    Repeati548 – 58942WD 2Add
    BLAST
    Repeati607 – 64741WD 3Add
    BLAST
    Repeati828 – 87043WD 4Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi151 – 1566Poly-Leu

    Sequence similaritiesi

    Contains 4 WD repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, WD repeat

    Phylogenomic databases

    eggNOGiNOG44594.
    HOGENOMiHOG000133051.
    HOVERGENiHBG056791.
    InParanoidiQ8WUA4.
    KOiK15200.
    OMAiRRFPIYK.
    OrthoDBiEOG7CNZF7.
    PhylomeDBiQ8WUA4.
    TreeFamiTF314779.

    Family and domain databases

    Gene3Di2.130.10.10. 2 hits.
    InterProiIPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF00400. WD40. 1 hit.
    [Graphical view]
    SMARTiSM00320. WD40. 4 hits.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 3 hits.
    PROSITEiPS00678. WD_REPEATS_1. 2 hits.
    PS50082. WD_REPEATS_2. 1 hit.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8WUA4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDTCGVGYVA LGEAGPVGNM TVVDSPGQEV LNQLDVKTSS EMTSAEASVE    50
    MSLPTPLPGF EDSPDQRRLP PEQESLSRLE QPDLSSEMSK VSKPRASKPG 100
    RKRGGRTRKG PKRPQQPNPP SAPLVPGLLD QSNPLSTPMP KKRGRKSKAE 150
    LLLLKLSKDL DRPESQSPKR PPEDFETPSG ERPRRRAAQV ALLYLQELAE 200
    ELSTALPAPV SCPEGPKVSS PTKPKKIRQP AACPGGEEVD GAPRDEDFFL 250
    QVEAEDVEES EGPSESSSEP EPVVPRSTPR GSTSGKQKPH CRGMAPNGLP 300
    NHIMAPVWKC LHLTKDFREQ KHSYWEFAEW IPLAWKWHLL SELEAAPYLP 350
    QEEKSPLFSV QREGLPEDGT LYRINRFSSI TAHPERWDVS FFTGGPLWAL 400
    DWCPVPEGAG ASQYVALFSS PDMNETHPLS QLHSGPGLLQ LWGLGTLQQE 450
    SCPGNRAHFV YGIACDNGCI WDLKFCPSGA WELPGTPRKA PLLPRLGLLA 500
    LACSDGKVLL FSLPHPEALL AQQPPDAVKP AIYKVQCVAT LQVGSMQATD 550
    PSECGQCLSL AWMPTRPHQH LAAGYYNGMV VFWNLPTNSP LQRIRLSDGS 600
    LKLYPFQCFL AHDQAVRTLQ WCKANSHFLV SAGSDRKIKF WDLRRPYEPI 650
    NSIKRFLSTE LAWLLPYNGV TVAQDNCYAS YGLCGIHYID AGYLGFKAYF 700
    TAPRKGTVWS LSGSDWLGTI AAGDISGELI AAILPDMALN PINVKRPVER 750
    RFPIYKADLI PYQDSPEGPD HSSASSGVPN PPKARTYTET VNHHYLLFQD 800
    TDLGSFHDLL RREPMLRMQE GEGHSQLCLD RLQLEAIHKV RFSPNLDSYG 850
    WLVSGGQSGL VRIHFVRGLA SPLGHRMQLE SRAHFNAMFQ PSSPTRRPGF 900
    SPTSHRLLPT P 911
    Length:911
    Mass (Da):100,680
    Last modified:June 7, 2004 - v2
    Checksum:iB59D91DE74555192
    GO
    Isoform 2 (identifier: Q8WUA4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         579-585: MVVFWNL → KKNQNKT
         586-911: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:585
    Mass (Da):64,003
    Checksum:i0CBDAE93F3E08D6B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti301 – 3011N → D in AAP88801. 1 PublicationCurated
    Sequence conflicti301 – 3011N → D in AAH20981. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei579 – 5857MVVFWNL → KKNQNKT in isoform 2. 1 PublicationVSP_010566
    Alternative sequencei586 – 911326Missing in isoform 2. 1 PublicationVSP_010567Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D13636 mRNA. Translation: BAA02800.1.
    BT009799 mRNA. Translation: AAP88801.1.
    CH471053 Genomic DNA. Translation: EAX00595.1.
    CH471053 Genomic DNA. Translation: EAX00596.1.
    BC000212 mRNA. Translation: AAH00212.1.
    BC020981 mRNA. Translation: AAH20981.1.
    AF054988 mRNA. Translation: AAC09349.1.
    CCDSiCCDS1749.1. [Q8WUA4-1]
    PIRiA56465.
    RefSeqiNP_001030598.1. NM_001035521.2. [Q8WUA4-1]
    NP_001512.1. NM_001521.3. [Q8WUA4-1]
    UniGeneiHs.745168.
    Hs.75782.

    Genome annotation databases

    EnsembliENST00000264720; ENSP00000264720; ENSG00000115207. [Q8WUA4-1]
    ENST00000359541; ENSP00000352536; ENSG00000115207. [Q8WUA4-1]
    GeneIDi2976.
    KEGGihsa:2976.
    UCSCiuc002rju.2. human. [Q8WUA4-1]
    uc010eyz.3. human. [Q8WUA4-2]

    Polymorphism databases

    DMDMi48428661.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D13636 mRNA. Translation: BAA02800.1 .
    BT009799 mRNA. Translation: AAP88801.1 .
    CH471053 Genomic DNA. Translation: EAX00595.1 .
    CH471053 Genomic DNA. Translation: EAX00596.1 .
    BC000212 mRNA. Translation: AAH00212.1 .
    BC020981 mRNA. Translation: AAH20981.1 .
    AF054988 mRNA. Translation: AAC09349.1 .
    CCDSi CCDS1749.1. [Q8WUA4-1 ]
    PIRi A56465.
    RefSeqi NP_001030598.1. NM_001035521.2. [Q8WUA4-1 ]
    NP_001512.1. NM_001521.3. [Q8WUA4-1 ]
    UniGenei Hs.745168.
    Hs.75782.

    3D structure databases

    ProteinModelPortali Q8WUA4.
    SMRi Q8WUA4. Positions 834-869.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109231. 19 interactions.
    DIPi DIP-38213N.
    IntActi Q8WUA4. 8 interactions.
    MINTi MINT-4535724.
    STRINGi 9606.ENSP00000264720.

    PTM databases

    PhosphoSitei Q8WUA4.

    Polymorphism databases

    DMDMi 48428661.

    Proteomic databases

    MaxQBi Q8WUA4.
    PaxDbi Q8WUA4.
    PRIDEi Q8WUA4.

    Protocols and materials databases

    DNASUi 2976.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000264720 ; ENSP00000264720 ; ENSG00000115207 . [Q8WUA4-1 ]
    ENST00000359541 ; ENSP00000352536 ; ENSG00000115207 . [Q8WUA4-1 ]
    GeneIDi 2976.
    KEGGi hsa:2976.
    UCSCi uc002rju.2. human. [Q8WUA4-1 ]
    uc010eyz.3. human. [Q8WUA4-2 ]

    Organism-specific databases

    CTDi 2976.
    GeneCardsi GC02M027548.
    HGNCi HGNC:4665. GTF3C2.
    HPAi HPA035836.
    MIMi 604883. gene.
    neXtProti NX_Q8WUA4.
    PharmGKBi PA29053.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG44594.
    HOGENOMi HOG000133051.
    HOVERGENi HBG056791.
    InParanoidi Q8WUA4.
    KOi K15200.
    OMAi RRFPIYK.
    OrthoDBi EOG7CNZF7.
    PhylomeDBi Q8WUA4.
    TreeFami TF314779.

    Enzyme and pathway databases

    Reactomei REACT_1036. RNA Polymerase III Transcription Initiation From Type 2 Promoter.
    REACT_22339. RNA Polymerase III Abortive And Retractive Initiation.
    REACT_347. RNA Polymerase III Transcription Initiation From Type 1 Promoter.
    SignaLinki Q8WUA4.

    Miscellaneous databases

    ChiTaRSi GTF3C2. human.
    GeneWikii GTF3C2.
    GenomeRNAii 2976.
    NextBioi 11802.
    PROi Q8WUA4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8WUA4.
    Bgeei Q8WUA4.
    CleanExi HS_GTF3C2.
    Genevestigatori Q8WUA4.

    Family and domain databases

    Gene3Di 2.130.10.10. 2 hits.
    InterProi IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF00400. WD40. 1 hit.
    [Graphical view ]
    SMARTi SM00320. WD40. 4 hits.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 3 hits.
    PROSITEi PS00678. WD_REPEATS_1. 2 hits.
    PS50082. WD_REPEATS_2. 1 hit.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of a TFIIIC2 subunit (TFIIIC beta) whose presence correlates with activation of RNA polymerase III-mediated transcription by adenovirus E1A expression and serum factors."
      Sinn E., Wang Z., Kovelman R., Roeder R.G.
      Genes Dev. 9:675-685(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 41-62; 338-354; 642-654 AND 757-774, IDENTIFICATION OF SUBUNITS OF TFIIIC2 COMPLEX.
    2. "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1."
      Nomura N., Miyajima N., Sazuka T., Tanaka A., Kawarabayasi Y., Sato S., Nagase T., Seki N., Ishikawa K., Tabata S.
      DNA Res. 1:27-35(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Bone marrow.
    3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain and Colon.
    6. Yu W., Gibbs R.A.
      Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 620-911.
      Tissue: Brain.
    7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
      J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-132 AND SER-167, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-63 AND THR-895, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-165; SER-167; SER-871; SER-892 AND SER-893, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-167; SER-220 AND SER-892, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiTF3C2_HUMAN
    AccessioniPrimary (citable) accession number: Q8WUA4
    Secondary accession number(s): D6W557, Q16632, Q9BWI7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2004
    Last sequence update: June 7, 2004
    Last modified: October 1, 2014
    This is version 122 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3