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Q8WUA4

- TF3C2_HUMAN

UniProt

Q8WUA4 - TF3C2_HUMAN

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Protein

General transcription factor 3C polypeptide 2

Gene

GTF3C2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. May play a direct role in stabilizing interactions of TFIIIC2 with TFIIIC1.

GO - Biological processi

  1. 5S class rRNA transcription from RNA polymerase III type 1 promoter Source: HGNC
  2. gene expression Source: Reactome
  3. transcription, DNA-templated Source: HGNC
  4. transcription from RNA polymerase III promoter Source: HGNC
  5. tRNA transcription from RNA polymerase III promoter Source: HGNC
Complete GO annotation...

Keywords - Biological processi

Transcription

Enzyme and pathway databases

ReactomeiREACT_1036. RNA Polymerase III Transcription Initiation From Type 2 Promoter.
REACT_22339. RNA Polymerase III Abortive And Retractive Initiation.
REACT_347. RNA Polymerase III Transcription Initiation From Type 1 Promoter.
SignaLinkiQ8WUA4.

Names & Taxonomyi

Protein namesi
Recommended name:
General transcription factor 3C polypeptide 2
Alternative name(s):
TF3C-beta
Transcription factor IIIC 110 kDa subunit
Short name:
TFIIIC 110 kDa subunit
Short name:
TFIIIC110
Transcription factor IIIC subunit beta
Gene namesi
Name:GTF3C2
Synonyms:KIAA0011
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:4665. GTF3C2.

Subcellular locationi

GO - Cellular componenti

  1. nucleoplasm Source: Reactome
  2. transcription factor TFIIIC complex Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29053.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 911911General transcription factor 3C polypeptide 2PRO_0000050985Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei63 – 631Phosphoserine1 Publication
Modified residuei132 – 1321Phosphoserine1 Publication
Modified residuei165 – 1651Phosphoserine1 Publication
Modified residuei167 – 1671Phosphoserine3 Publications
Modified residuei220 – 2201Phosphoserine1 Publication
Modified residuei871 – 8711Phosphoserine1 Publication
Modified residuei892 – 8921Phosphoserine2 Publications
Modified residuei893 – 8931Phosphoserine1 Publication
Modified residuei895 – 8951Phosphothreonine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8WUA4.
PaxDbiQ8WUA4.
PRIDEiQ8WUA4.

PTM databases

PhosphoSiteiQ8WUA4.

Expressioni

Gene expression databases

BgeeiQ8WUA4.
CleanExiHS_GTF3C2.
ExpressionAtlasiQ8WUA4. baseline and differential.
GenevestigatoriQ8WUA4.

Organism-specific databases

HPAiHPA035836.

Interactioni

Subunit structurei

Part of the TFIIIC subcomplex TFIIIC2, consisting of six subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5 and GTF3C6.

Protein-protein interaction databases

BioGridi109231. 24 interactions.
DIPiDIP-38213N.
IntActiQ8WUA4. 8 interactions.
MINTiMINT-4535724.
STRINGi9606.ENSP00000264720.

Structurei

3D structure databases

ProteinModelPortaliQ8WUA4.
SMRiQ8WUA4. Positions 556-646, 834-869.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati461 – 51757WD 1Add
BLAST
Repeati548 – 58942WD 2Add
BLAST
Repeati607 – 64741WD 3Add
BLAST
Repeati828 – 87043WD 4Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi151 – 1566Poly-Leu

Sequence similaritiesi

Contains 4 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiNOG44594.
GeneTreeiENSGT00390000018632.
HOGENOMiHOG000133051.
HOVERGENiHBG056791.
InParanoidiQ8WUA4.
KOiK15200.
OMAiRRFPIYK.
OrthoDBiEOG7CNZF7.
PhylomeDBiQ8WUA4.
TreeFamiTF314779.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 3 hits.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8WUA4) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDTCGVGYVA LGEAGPVGNM TVVDSPGQEV LNQLDVKTSS EMTSAEASVE
60 70 80 90 100
MSLPTPLPGF EDSPDQRRLP PEQESLSRLE QPDLSSEMSK VSKPRASKPG
110 120 130 140 150
RKRGGRTRKG PKRPQQPNPP SAPLVPGLLD QSNPLSTPMP KKRGRKSKAE
160 170 180 190 200
LLLLKLSKDL DRPESQSPKR PPEDFETPSG ERPRRRAAQV ALLYLQELAE
210 220 230 240 250
ELSTALPAPV SCPEGPKVSS PTKPKKIRQP AACPGGEEVD GAPRDEDFFL
260 270 280 290 300
QVEAEDVEES EGPSESSSEP EPVVPRSTPR GSTSGKQKPH CRGMAPNGLP
310 320 330 340 350
NHIMAPVWKC LHLTKDFREQ KHSYWEFAEW IPLAWKWHLL SELEAAPYLP
360 370 380 390 400
QEEKSPLFSV QREGLPEDGT LYRINRFSSI TAHPERWDVS FFTGGPLWAL
410 420 430 440 450
DWCPVPEGAG ASQYVALFSS PDMNETHPLS QLHSGPGLLQ LWGLGTLQQE
460 470 480 490 500
SCPGNRAHFV YGIACDNGCI WDLKFCPSGA WELPGTPRKA PLLPRLGLLA
510 520 530 540 550
LACSDGKVLL FSLPHPEALL AQQPPDAVKP AIYKVQCVAT LQVGSMQATD
560 570 580 590 600
PSECGQCLSL AWMPTRPHQH LAAGYYNGMV VFWNLPTNSP LQRIRLSDGS
610 620 630 640 650
LKLYPFQCFL AHDQAVRTLQ WCKANSHFLV SAGSDRKIKF WDLRRPYEPI
660 670 680 690 700
NSIKRFLSTE LAWLLPYNGV TVAQDNCYAS YGLCGIHYID AGYLGFKAYF
710 720 730 740 750
TAPRKGTVWS LSGSDWLGTI AAGDISGELI AAILPDMALN PINVKRPVER
760 770 780 790 800
RFPIYKADLI PYQDSPEGPD HSSASSGVPN PPKARTYTET VNHHYLLFQD
810 820 830 840 850
TDLGSFHDLL RREPMLRMQE GEGHSQLCLD RLQLEAIHKV RFSPNLDSYG
860 870 880 890 900
WLVSGGQSGL VRIHFVRGLA SPLGHRMQLE SRAHFNAMFQ PSSPTRRPGF
910
SPTSHRLLPT P
Length:911
Mass (Da):100,680
Last modified:June 7, 2004 - v2
Checksum:iB59D91DE74555192
GO
Isoform 2 (identifier: Q8WUA4-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     579-585: MVVFWNL → KKNQNKT
     586-911: Missing.

Note: No experimental confirmation available.

Show »
Length:585
Mass (Da):64,003
Checksum:i0CBDAE93F3E08D6B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti301 – 3011N → D in AAP88801. 1 PublicationCurated
Sequence conflicti301 – 3011N → D in AAH20981. 1 PublicationCurated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei579 – 5857MVVFWNL → KKNQNKT in isoform 2. 1 PublicationVSP_010566
Alternative sequencei586 – 911326Missing in isoform 2. 1 PublicationVSP_010567Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D13636 mRNA. Translation: BAA02800.1.
BT009799 mRNA. Translation: AAP88801.1.
CH471053 Genomic DNA. Translation: EAX00595.1.
CH471053 Genomic DNA. Translation: EAX00596.1.
BC000212 mRNA. Translation: AAH00212.1.
BC020981 mRNA. Translation: AAH20981.1.
AF054988 mRNA. Translation: AAC09349.1.
CCDSiCCDS1749.1. [Q8WUA4-1]
PIRiA56465.
RefSeqiNP_001030598.1. NM_001035521.2. [Q8WUA4-1]
NP_001512.1. NM_001521.3. [Q8WUA4-1]
UniGeneiHs.745168.
Hs.75782.

Genome annotation databases

EnsembliENST00000264720; ENSP00000264720; ENSG00000115207. [Q8WUA4-1]
ENST00000359541; ENSP00000352536; ENSG00000115207. [Q8WUA4-1]
GeneIDi2976.
KEGGihsa:2976.
UCSCiuc002rju.2. human. [Q8WUA4-1]
uc010eyz.3. human. [Q8WUA4-2]

Polymorphism databases

DMDMi48428661.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D13636 mRNA. Translation: BAA02800.1 .
BT009799 mRNA. Translation: AAP88801.1 .
CH471053 Genomic DNA. Translation: EAX00595.1 .
CH471053 Genomic DNA. Translation: EAX00596.1 .
BC000212 mRNA. Translation: AAH00212.1 .
BC020981 mRNA. Translation: AAH20981.1 .
AF054988 mRNA. Translation: AAC09349.1 .
CCDSi CCDS1749.1. [Q8WUA4-1 ]
PIRi A56465.
RefSeqi NP_001030598.1. NM_001035521.2. [Q8WUA4-1 ]
NP_001512.1. NM_001521.3. [Q8WUA4-1 ]
UniGenei Hs.745168.
Hs.75782.

3D structure databases

ProteinModelPortali Q8WUA4.
SMRi Q8WUA4. Positions 556-646, 834-869.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109231. 24 interactions.
DIPi DIP-38213N.
IntActi Q8WUA4. 8 interactions.
MINTi MINT-4535724.
STRINGi 9606.ENSP00000264720.

PTM databases

PhosphoSitei Q8WUA4.

Polymorphism databases

DMDMi 48428661.

Proteomic databases

MaxQBi Q8WUA4.
PaxDbi Q8WUA4.
PRIDEi Q8WUA4.

Protocols and materials databases

DNASUi 2976.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000264720 ; ENSP00000264720 ; ENSG00000115207 . [Q8WUA4-1 ]
ENST00000359541 ; ENSP00000352536 ; ENSG00000115207 . [Q8WUA4-1 ]
GeneIDi 2976.
KEGGi hsa:2976.
UCSCi uc002rju.2. human. [Q8WUA4-1 ]
uc010eyz.3. human. [Q8WUA4-2 ]

Organism-specific databases

CTDi 2976.
GeneCardsi GC02M027548.
HGNCi HGNC:4665. GTF3C2.
HPAi HPA035836.
MIMi 604883. gene.
neXtProti NX_Q8WUA4.
PharmGKBi PA29053.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG44594.
GeneTreei ENSGT00390000018632.
HOGENOMi HOG000133051.
HOVERGENi HBG056791.
InParanoidi Q8WUA4.
KOi K15200.
OMAi RRFPIYK.
OrthoDBi EOG7CNZF7.
PhylomeDBi Q8WUA4.
TreeFami TF314779.

Enzyme and pathway databases

Reactomei REACT_1036. RNA Polymerase III Transcription Initiation From Type 2 Promoter.
REACT_22339. RNA Polymerase III Abortive And Retractive Initiation.
REACT_347. RNA Polymerase III Transcription Initiation From Type 1 Promoter.
SignaLinki Q8WUA4.

Miscellaneous databases

ChiTaRSi GTF3C2. human.
GeneWikii GTF3C2.
GenomeRNAii 2976.
NextBioi 11802.
PROi Q8WUA4.
SOURCEi Search...

Gene expression databases

Bgeei Q8WUA4.
CleanExi HS_GTF3C2.
ExpressionAtlasi Q8WUA4. baseline and differential.
Genevestigatori Q8WUA4.

Family and domain databases

Gene3Di 2.130.10.10. 2 hits.
InterProi IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF00400. WD40. 1 hit.
[Graphical view ]
SMARTi SM00320. WD40. 4 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 3 hits.
PROSITEi PS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a TFIIIC2 subunit (TFIIIC beta) whose presence correlates with activation of RNA polymerase III-mediated transcription by adenovirus E1A expression and serum factors."
    Sinn E., Wang Z., Kovelman R., Roeder R.G.
    Genes Dev. 9:675-685(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 41-62; 338-354; 642-654 AND 757-774, IDENTIFICATION OF SUBUNITS OF TFIIIC2 COMPLEX.
  2. "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1."
    Nomura N., Miyajima N., Sazuka T., Tanaka A., Kawarabayasi Y., Sato S., Nagase T., Seki N., Ishikawa K., Tabata S.
    DNA Res. 1:27-35(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Bone marrow.
  3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain and Colon.
  6. Yu W., Gibbs R.A.
    Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 620-911.
    Tissue: Brain.
  7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-132 AND SER-167, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-63 AND THR-895, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-165; SER-167; SER-871; SER-892 AND SER-893, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-167; SER-220 AND SER-892, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTF3C2_HUMAN
AccessioniPrimary (citable) accession number: Q8WUA4
Secondary accession number(s): D6W557, Q16632, Q9BWI7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: October 29, 2014
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3