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Protein

General transcription factor 3C polypeptide 2

Gene

GTF3C2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for RNA polymerase III-mediated transcription. Component of TFIIIC that initiates transcription complex assembly on tRNA and is required for transcription of 5S rRNA and other stable nuclear and cytoplasmic RNAs. May play a direct role in stabilizing interactions of TFIIIC2 with TFIIIC1.

GO - Biological processi

  • 5S class rRNA transcription from RNA polymerase III type 1 promoter Source: HGNC
  • transcription, DNA-templated Source: HGNC
  • transcription from RNA polymerase III promoter Source: HGNC
  • tRNA transcription from RNA polymerase III promoter Source: HGNC
Complete GO annotation...

Keywords - Biological processi

Transcription

Enzyme and pathway databases

ReactomeiR-HSA-749476. RNA Polymerase III Abortive And Retractive Initiation.
R-HSA-76061. RNA Polymerase III Transcription Initiation From Type 1 Promoter.
R-HSA-76066. RNA Polymerase III Transcription Initiation From Type 2 Promoter.
SignaLinkiQ8WUA4.

Names & Taxonomyi

Protein namesi
Recommended name:
General transcription factor 3C polypeptide 2
Alternative name(s):
TF3C-beta
Transcription factor IIIC 110 kDa subunit
Short name:
TFIIIC 110 kDa subunit
Short name:
TFIIIC110
Transcription factor IIIC subunit beta
Gene namesi
Name:GTF3C2
Synonyms:KIAA0011
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:4665. GTF3C2.

Subcellular locationi

GO - Cellular componenti

  • nucleoplasm Source: Reactome
  • transcription factor TFIIIC complex Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000115207.
PharmGKBiPA29053.

Polymorphism and mutation databases

DMDMi48428661.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000509851 – 911General transcription factor 3C polypeptide 2Add BLAST911

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei63PhosphoserineCombined sources1
Modified residuei132PhosphoserineCombined sources1
Modified residuei165PhosphoserineCombined sources1
Modified residuei167PhosphoserineCombined sources1
Modified residuei220PhosphoserineCombined sources1
Modified residuei260PhosphoserineCombined sources1
Modified residuei597PhosphoserineCombined sources1
Modified residuei871PhosphoserineCombined sources1
Modified residuei892PhosphoserineCombined sources1
Modified residuei893PhosphoserineCombined sources1
Modified residuei895PhosphothreonineCombined sources1
Modified residuei901PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8WUA4.
MaxQBiQ8WUA4.
PaxDbiQ8WUA4.
PeptideAtlasiQ8WUA4.
PRIDEiQ8WUA4.

PTM databases

iPTMnetiQ8WUA4.
PhosphoSitePlusiQ8WUA4.

Expressioni

Gene expression databases

BgeeiENSG00000115207.
CleanExiHS_GTF3C2.
ExpressionAtlasiQ8WUA4. baseline and differential.
GenevisibleiQ8WUA4. HS.

Organism-specific databases

HPAiHPA035836.

Interactioni

Subunit structurei

Part of the TFIIIC subcomplex TFIIIC2, consisting of six subunits, GTF3C1, GTF3C2, GTF3C3, GTF3C4, GTF3C5 and GTF3C6.

Protein-protein interaction databases

BioGridi109231. 64 interactors.
DIPiDIP-38213N.
IntActiQ8WUA4. 24 interactors.
MINTiMINT-4535724.
STRINGi9606.ENSP00000264720.

Structurei

3D structure databases

ProteinModelPortaliQ8WUA4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati366 – 426WD 1Add BLAST61
Repeati427 – 483WD 2Add BLAST57
Repeati484 – 535WD 3Add BLAST52
Repeati536 – 603WD 4Add BLAST68
Repeati604 – 654WD 5Add BLAST51
Repeati655 – 690WD 6Add BLAST36

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi151 – 156Poly-Leu6

Sequence similaritiesi

Contains 6 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiENOG410IG5U. Eukaryota.
ENOG410YFGF. LUCA.
GeneTreeiENSGT00390000018632.
HOGENOMiHOG000133051.
HOVERGENiHBG056791.
InParanoidiQ8WUA4.
KOiK15200.
OMAiKPAIYKV.
OrthoDBiEOG091G07LV.
PhylomeDBiQ8WUA4.
TreeFamiTF314779.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 3 hits.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WUA4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDTCGVGYVA LGEAGPVGNM TVVDSPGQEV LNQLDVKTSS EMTSAEASVE
60 70 80 90 100
MSLPTPLPGF EDSPDQRRLP PEQESLSRLE QPDLSSEMSK VSKPRASKPG
110 120 130 140 150
RKRGGRTRKG PKRPQQPNPP SAPLVPGLLD QSNPLSTPMP KKRGRKSKAE
160 170 180 190 200
LLLLKLSKDL DRPESQSPKR PPEDFETPSG ERPRRRAAQV ALLYLQELAE
210 220 230 240 250
ELSTALPAPV SCPEGPKVSS PTKPKKIRQP AACPGGEEVD GAPRDEDFFL
260 270 280 290 300
QVEAEDVEES EGPSESSSEP EPVVPRSTPR GSTSGKQKPH CRGMAPNGLP
310 320 330 340 350
NHIMAPVWKC LHLTKDFREQ KHSYWEFAEW IPLAWKWHLL SELEAAPYLP
360 370 380 390 400
QEEKSPLFSV QREGLPEDGT LYRINRFSSI TAHPERWDVS FFTGGPLWAL
410 420 430 440 450
DWCPVPEGAG ASQYVALFSS PDMNETHPLS QLHSGPGLLQ LWGLGTLQQE
460 470 480 490 500
SCPGNRAHFV YGIACDNGCI WDLKFCPSGA WELPGTPRKA PLLPRLGLLA
510 520 530 540 550
LACSDGKVLL FSLPHPEALL AQQPPDAVKP AIYKVQCVAT LQVGSMQATD
560 570 580 590 600
PSECGQCLSL AWMPTRPHQH LAAGYYNGMV VFWNLPTNSP LQRIRLSDGS
610 620 630 640 650
LKLYPFQCFL AHDQAVRTLQ WCKANSHFLV SAGSDRKIKF WDLRRPYEPI
660 670 680 690 700
NSIKRFLSTE LAWLLPYNGV TVAQDNCYAS YGLCGIHYID AGYLGFKAYF
710 720 730 740 750
TAPRKGTVWS LSGSDWLGTI AAGDISGELI AAILPDMALN PINVKRPVER
760 770 780 790 800
RFPIYKADLI PYQDSPEGPD HSSASSGVPN PPKARTYTET VNHHYLLFQD
810 820 830 840 850
TDLGSFHDLL RREPMLRMQE GEGHSQLCLD RLQLEAIHKV RFSPNLDSYG
860 870 880 890 900
WLVSGGQSGL VRIHFVRGLA SPLGHRMQLE SRAHFNAMFQ PSSPTRRPGF
910
SPTSHRLLPT P
Length:911
Mass (Da):100,680
Last modified:June 7, 2004 - v2
Checksum:iB59D91DE74555192
GO
Isoform 2 (identifier: Q8WUA4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     579-585: MVVFWNL → KKNQNKT
     586-911: Missing.

Note: No experimental confirmation available.
Show »
Length:585
Mass (Da):64,003
Checksum:i0CBDAE93F3E08D6B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti301N → D in AAP88801 (Ref. 3) Curated1
Sequence conflicti301N → D in AAH20981 (Ref. 4) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_010566579 – 585MVVFWNL → KKNQNKT in isoform 2. 1 Publication7
Alternative sequenceiVSP_010567586 – 911Missing in isoform 2. 1 PublicationAdd BLAST326

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13636 mRNA. Translation: BAA02800.1.
BT009799 mRNA. Translation: AAP88801.1.
CH471053 Genomic DNA. Translation: EAX00595.1.
CH471053 Genomic DNA. Translation: EAX00596.1.
BC000212 mRNA. Translation: AAH00212.1.
BC020981 mRNA. Translation: AAH20981.1.
AF054988 mRNA. Translation: AAC09349.1.
CCDSiCCDS1749.1. [Q8WUA4-1]
PIRiA56465.
RefSeqiNP_001030598.1. NM_001035521.2. [Q8WUA4-1]
NP_001305838.1. NM_001318909.1.
NP_001512.1. NM_001521.3. [Q8WUA4-1]
UniGeneiHs.745168.
Hs.75782.

Genome annotation databases

EnsembliENST00000264720; ENSP00000264720; ENSG00000115207. [Q8WUA4-1]
ENST00000359541; ENSP00000352536; ENSG00000115207. [Q8WUA4-1]
GeneIDi2976.
KEGGihsa:2976.
UCSCiuc002rju.3. human. [Q8WUA4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D13636 mRNA. Translation: BAA02800.1.
BT009799 mRNA. Translation: AAP88801.1.
CH471053 Genomic DNA. Translation: EAX00595.1.
CH471053 Genomic DNA. Translation: EAX00596.1.
BC000212 mRNA. Translation: AAH00212.1.
BC020981 mRNA. Translation: AAH20981.1.
AF054988 mRNA. Translation: AAC09349.1.
CCDSiCCDS1749.1. [Q8WUA4-1]
PIRiA56465.
RefSeqiNP_001030598.1. NM_001035521.2. [Q8WUA4-1]
NP_001305838.1. NM_001318909.1.
NP_001512.1. NM_001521.3. [Q8WUA4-1]
UniGeneiHs.745168.
Hs.75782.

3D structure databases

ProteinModelPortaliQ8WUA4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109231. 64 interactors.
DIPiDIP-38213N.
IntActiQ8WUA4. 24 interactors.
MINTiMINT-4535724.
STRINGi9606.ENSP00000264720.

PTM databases

iPTMnetiQ8WUA4.
PhosphoSitePlusiQ8WUA4.

Polymorphism and mutation databases

DMDMi48428661.

Proteomic databases

EPDiQ8WUA4.
MaxQBiQ8WUA4.
PaxDbiQ8WUA4.
PeptideAtlasiQ8WUA4.
PRIDEiQ8WUA4.

Protocols and materials databases

DNASUi2976.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264720; ENSP00000264720; ENSG00000115207. [Q8WUA4-1]
ENST00000359541; ENSP00000352536; ENSG00000115207. [Q8WUA4-1]
GeneIDi2976.
KEGGihsa:2976.
UCSCiuc002rju.3. human. [Q8WUA4-1]

Organism-specific databases

CTDi2976.
GeneCardsiGTF3C2.
HGNCiHGNC:4665. GTF3C2.
HPAiHPA035836.
MIMi604883. gene.
neXtProtiNX_Q8WUA4.
OpenTargetsiENSG00000115207.
PharmGKBiPA29053.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IG5U. Eukaryota.
ENOG410YFGF. LUCA.
GeneTreeiENSGT00390000018632.
HOGENOMiHOG000133051.
HOVERGENiHBG056791.
InParanoidiQ8WUA4.
KOiK15200.
OMAiKPAIYKV.
OrthoDBiEOG091G07LV.
PhylomeDBiQ8WUA4.
TreeFamiTF314779.

Enzyme and pathway databases

ReactomeiR-HSA-749476. RNA Polymerase III Abortive And Retractive Initiation.
R-HSA-76061. RNA Polymerase III Transcription Initiation From Type 1 Promoter.
R-HSA-76066. RNA Polymerase III Transcription Initiation From Type 2 Promoter.
SignaLinkiQ8WUA4.

Miscellaneous databases

ChiTaRSiGTF3C2. human.
GeneWikiiGTF3C2.
GenomeRNAii2976.
PROiQ8WUA4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000115207.
CleanExiHS_GTF3C2.
ExpressionAtlasiQ8WUA4. baseline and differential.
GenevisibleiQ8WUA4. HS.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 3 hits.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTF3C2_HUMAN
AccessioniPrimary (citable) accession number: Q8WUA4
Secondary accession number(s): D6W557, Q16632, Q9BWI7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: June 7, 2004
Last modified: November 30, 2016
This is version 146 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.