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Protein

Peptidyl-prolyl cis-trans isomerase-like 4

Gene

PPIL4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).By similarity

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciZFISH:HS05468-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase-like 4 (EC:5.2.1.8)
Short name:
PPIase
Alternative name(s):
Cyclophilin-like protein PPIL4
Rotamase PPIL4
Gene namesi
Name:PPIL4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:15702. PPIL4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi85313.
OpenTargetsiENSG00000131013.
PharmGKBiPA33590.

Polymorphism and mutation databases

BioMutaiPPIL4.
DMDMi74760546.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002330521 – 492Peptidyl-prolyl cis-trans isomerase-like 4Add BLAST492

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei178PhosphoserineCombined sources1
Modified residuei182PhosphothreonineCombined sources1
Modified residuei393PhosphoserineBy similarity1
Modified residuei471PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8WUA2.
MaxQBiQ8WUA2.
PaxDbiQ8WUA2.
PeptideAtlasiQ8WUA2.
PRIDEiQ8WUA2.

PTM databases

iPTMnetiQ8WUA2.
PhosphoSitePlusiQ8WUA2.

Expressioni

Tissue specificityi

Abundantly expressed in kidney but has a ubiquitously low expression pattern in other adult tissues.1 Publication

Gene expression databases

BgeeiENSG00000131013.
CleanExiHS_PPIL4.
ExpressionAtlasiQ8WUA2. baseline and differential.
GenevisibleiQ8WUA2. HS.

Organism-specific databases

HPAiHPA031599.
HPA031600.

Interactioni

Protein-protein interaction databases

BioGridi124467. 24 interactors.
IntActiQ8WUA2. 10 interactors.
MINTiMINT-1182736.
STRINGi9606.ENSP00000253329.

Structurei

3D structure databases

ProteinModelPortaliQ8WUA2.
SMRiQ8WUA2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 161PPIase cyclophilin-typePROSITE-ProRule annotationAdd BLAST161
Domaini240 – 318RRMPROSITE-ProRule annotationAdd BLAST79

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi321 – 388Lys-richAdd BLAST68

Sequence similaritiesi

Contains 1 PPIase cyclophilin-type domain.PROSITE-ProRule annotation
Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0415. Eukaryota.
COG0652. LUCA.
GeneTreeiENSGT00760000119072.
HOGENOMiHOG000186284.
HOVERGENiHBG057731.
InParanoidiQ8WUA2.
KOiK12735.
OMAiDPYPDPA.
OrthoDBiEOG091G0DCF.
PhylomeDBiQ8WUA2.
TreeFamiTF351865.

Family and domain databases

Gene3Di2.40.100.10. 1 hit.
3.30.70.330. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR002130. Cyclophilin-type_PPIase_dom.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PANTHERiPTHR11071. PTHR11071. 1 hit.
PfamiPF00160. Pro_isomerase. 1 hit.
PF00076. RRM_1. 1 hit.
[Graphical view]
PRINTSiPR00153. CSAPPISMRASE.
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF50891. SSF50891. 1 hit.
SSF54928. SSF54928. 1 hit.
PROSITEiPS50072. CSA_PPIASE_2. 1 hit.
PS50102. RRM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WUA2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVLLETTLG DVVIDLYTEE RPRACLNFLK LCKIKYYNYC LIHNVQRDFI
60 70 80 90 100
IQTGDPTGTG RGGESIFGQL YGDQASFFEA EKVPRIKHKK KGTVSMVNNG
110 120 130 140 150
SDQHGSQFLI TTGENLDYLD GVHTVFGEVT EGMDIIKKIN ETFVDKDFVP
160 170 180 190 200
YQDIRINHTV ILDDPFDDPP DLLIPDRSPE PTREQLDSGR IGADEEIDDF
210 220 230 240 250
KGRSAEEVEE IKAEKEAKTQ AILLEMVGDL PDADIKPPEN VLFVCKLNPV
260 270 280 290 300
TTDEDLEIIF SRFGPIRSCE VIRDWKTGES LCYAFIEFEK EEDCEKAFFK
310 320 330 340 350
MDNVLIDDRR IHVDFSQSVA KVKWKGKGGK YTKSDFKEYE KEQDKPPNLV
360 370 380 390 400
LKDKVKPKQD TKYDLILDEQ AEDSKSSHSH TSKKHKKKTH HCSEEKEDED
410 420 430 440 450
YMPIKNTNQD IYREMGFGHY EEEESCWEKQ KSEKRDRTQN RSRSRSRERD
460 470 480 490
GHYSNSHKSK YQTDLYERER SKKRDRSRSP KKSKDKEKSK YR
Length:492
Mass (Da):57,225
Last modified:March 1, 2002 - v1
Checksum:i6888B62802E15989
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti389T → A in CAD97776 (PubMed:17974005).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF357880 mRNA. Translation: AAM63961.1.
AK315388 mRNA. Translation: BAG37781.1.
BX537536 mRNA. Translation: CAD97776.1.
AL078581, AL357619 Genomic DNA. Translation: CAI19508.1.
AL357619, AL078581 Genomic DNA. Translation: CAI16471.1.
CH471051 Genomic DNA. Translation: EAW47799.1.
BC020986 mRNA. Translation: AAH20986.1.
CCDSiCCDS34550.1.
RefSeqiNP_624311.1. NM_139126.3.
UniGeneiHs.744238.

Genome annotation databases

EnsembliENST00000253329; ENSP00000253329; ENSG00000131013.
GeneIDi85313.
KEGGihsa:85313.
UCSCiuc003qmo.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF357880 mRNA. Translation: AAM63961.1.
AK315388 mRNA. Translation: BAG37781.1.
BX537536 mRNA. Translation: CAD97776.1.
AL078581, AL357619 Genomic DNA. Translation: CAI19508.1.
AL357619, AL078581 Genomic DNA. Translation: CAI16471.1.
CH471051 Genomic DNA. Translation: EAW47799.1.
BC020986 mRNA. Translation: AAH20986.1.
CCDSiCCDS34550.1.
RefSeqiNP_624311.1. NM_139126.3.
UniGeneiHs.744238.

3D structure databases

ProteinModelPortaliQ8WUA2.
SMRiQ8WUA2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124467. 24 interactors.
IntActiQ8WUA2. 10 interactors.
MINTiMINT-1182736.
STRINGi9606.ENSP00000253329.

PTM databases

iPTMnetiQ8WUA2.
PhosphoSitePlusiQ8WUA2.

Polymorphism and mutation databases

BioMutaiPPIL4.
DMDMi74760546.

Proteomic databases

EPDiQ8WUA2.
MaxQBiQ8WUA2.
PaxDbiQ8WUA2.
PeptideAtlasiQ8WUA2.
PRIDEiQ8WUA2.

Protocols and materials databases

DNASUi85313.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000253329; ENSP00000253329; ENSG00000131013.
GeneIDi85313.
KEGGihsa:85313.
UCSCiuc003qmo.3. human.

Organism-specific databases

CTDi85313.
DisGeNETi85313.
GeneCardsiPPIL4.
HGNCiHGNC:15702. PPIL4.
HPAiHPA031599.
HPA031600.
MIMi607609. gene.
neXtProtiNX_Q8WUA2.
OpenTargetsiENSG00000131013.
PharmGKBiPA33590.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0415. Eukaryota.
COG0652. LUCA.
GeneTreeiENSGT00760000119072.
HOGENOMiHOG000186284.
HOVERGENiHBG057731.
InParanoidiQ8WUA2.
KOiK12735.
OMAiDPYPDPA.
OrthoDBiEOG091G0DCF.
PhylomeDBiQ8WUA2.
TreeFamiTF351865.

Enzyme and pathway databases

BioCyciZFISH:HS05468-MONOMER.

Miscellaneous databases

ChiTaRSiPPIL4. human.
GeneWikiiPPIL4.
GenomeRNAii85313.
PROiQ8WUA2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000131013.
CleanExiHS_PPIL4.
ExpressionAtlasiQ8WUA2. baseline and differential.
GenevisibleiQ8WUA2. HS.

Family and domain databases

Gene3Di2.40.100.10. 1 hit.
3.30.70.330. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR002130. Cyclophilin-type_PPIase_dom.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PANTHERiPTHR11071. PTHR11071. 1 hit.
PfamiPF00160. Pro_isomerase. 1 hit.
PF00076. RRM_1. 1 hit.
[Graphical view]
PRINTSiPR00153. CSAPPISMRASE.
SMARTiSM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF50891. SSF50891. 1 hit.
SSF54928. SSF54928. 1 hit.
PROSITEiPS50072. CSA_PPIASE_2. 1 hit.
PS50102. RRM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPPIL4_HUMAN
AccessioniPrimary (citable) accession number: Q8WUA2
Secondary accession number(s): B2RD34, Q7Z3Q5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: March 1, 2002
Last modified: November 30, 2016
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.