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Protein

Zinc finger CCCH domain-containing protein 15

Gene

ZC3H15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Protects DRG1 from proteolytic degradation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri99 – 126C3H1-type 1PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri174 – 212C3H1-type 2PROSITE-ProRule annotationAdd BLAST39

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL
  • metal ion binding Source: UniProtKB-KW
  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000065548-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger CCCH domain-containing protein 15
Alternative name(s):
DRG family-regulatory protein 1
Likely ortholog of mouse immediate early response erythropoietin 4
Gene namesi
Name:ZC3H15
Synonyms:DFRP1, LEREPO4
ORF Names:HSPC303, HT010, MSTP012, PP730
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:29528. ZC3H15.

Subcellular locationi

GO - Cellular componenti

  • cell-cell adherens junction Source: BHF-UCL
  • cytoplasm Source: HPA
  • nucleolus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi55854.
OpenTargetsiENSG00000065548.
PharmGKBiPA162409508.

Polymorphism and mutation databases

BioMutaiZC3H15.
DMDMi74730681.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003246421 – 426Zinc finger CCCH domain-containing protein 15Add BLAST426

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei231PhosphoserineCombined sources1
Modified residuei351PhosphoserineCombined sources1
Modified residuei360PhosphoserineCombined sources1
Modified residuei381PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8WU90.
MaxQBiQ8WU90.
PaxDbiQ8WU90.
PeptideAtlasiQ8WU90.
PRIDEiQ8WU90.

PTM databases

iPTMnetiQ8WU90.
PhosphoSitePlusiQ8WU90.

Expressioni

Gene expression databases

BgeeiENSG00000065548.
CleanExiHS_ZC3H15.
ExpressionAtlasiQ8WU90. baseline and differential.
GenevisibleiQ8WU90. HS.

Organism-specific databases

HPAiHPA031099.
HPA031100.
HPA031101.

Interactioni

Subunit structurei

Interacts with DRG1; the interaction forms a polysomal DRG1-DFRP1/ZC3H15 complex which provides protein stability to DRG1 possibly by blocking poly-ubiquitination.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
DRG1Q9Y2957EBI-1042636,EBI-719554

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL

Protein-protein interaction databases

BioGridi120956. 39 interactors.
IntActiQ8WU90. 17 interactors.
MINTiMINT-4929572.
STRINGi9606.ENSP00000338788.

Structurei

3D structure databases

ProteinModelPortaliQ8WU90.
SMRiQ8WU90.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni236 – 260Required for interaction with DRG1By similarityAdd BLAST25

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili61 – 86Sequence analysisAdd BLAST26
Coiled coili218 – 285Sequence analysisAdd BLAST68

Sequence similaritiesi

Belongs to the ZC3H15/TMA46 family.Curated
Contains 2 C3H1-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri99 – 126C3H1-type 1PROSITE-ProRule annotationAdd BLAST28
Zinc fingeri174 – 212C3H1-type 2PROSITE-ProRule annotationAdd BLAST39

Keywords - Domaini

Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1763. Eukaryota.
COG5252. LUCA.
GeneTreeiENSGT00390000015818.
HOVERGENiHBG108761.
InParanoidiQ8WU90.
OMAiHDLSMER.
OrthoDBiEOG091G0DYW.
PhylomeDBiQ8WU90.
TreeFamiTF300892.

Family and domain databases

Gene3Di4.10.1000.10. 1 hit.
InterProiIPR032378. ZC3H15/TMA46_C.
IPR000571. Znf_CCCH.
[Graphical view]
PfamiPF16543. DFRP_C. 1 hit.
PF00642. zf-CCCH. 1 hit.
[Graphical view]
SMARTiSM00356. ZnF_C3H1. 2 hits.
[Graphical view]
SUPFAMiSSF90229. SSF90229. 1 hit.
PROSITEiPS50103. ZF_C3H1. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WU90-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPPKKQAQAG GSKKAEQKKK EKIIEDKTFG LKNKKGAKQQ KFIKAVTHQV
60 70 80 90 100
KFGQQNPRQV AQSEAEKKLK KDDKKKELQE LNELFKPVVA AQKISKGADP
110 120 130 140 150
KSVVCAFFKQ GQCTKGDKCK FSHDLTLERK CEKRSVYIDA RDEELEKDTM
160 170 180 190 200
DNWDEKKLEE VVNKKHGEAE KKKPKTQIVC KHFLEAIENN KYGWFWVCPG
210 220 230 240 250
GGDICMYRHA LPPGFVLKKD KKKEEKEDEI SLEDLIERER SALGPNVTKI
260 270 280 290 300
TLESFLAWKK RKRQEKIDKL EQDMERRKAD FKAGKALVIS GREVFEFRPE
310 320 330 340 350
LVNDDDEEAD DTRYTQGTGG DEVDDSVSVN DIDLSLYIPR DVDETGITVA
360 370 380 390 400
SLERFSTYTS DKDENKLSEA SGGRAENGER SDLEEDNERE GTENGAIDAV
410 420
PVDENLFTGE DLDELEEELN TLDLEE
Length:426
Mass (Da):48,602
Last modified:March 1, 2002 - v1
Checksum:i4A80B7FDC3376181
GO
Isoform 2 (identifier: Q8WU90-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-205: Missing.
     324-367: DDSVSVNDID...YTSDKDENKL → RGSFVPHLLM...VQILTPTMGN
     368-426: Missing.

Note: No experimental confirmation available.
Show »
Length:162
Mass (Da):18,947
Checksum:iD6013402EDED333C
GO

Sequence cautioni

The sequence AAF28981 differs from that shown. Reason: Frameshift at position 17.Curated
The sequence AAF67649 differs from that shown. Reason: Frameshift at positions 392, 407 and 422.Curated
The sequence AAL55770 differs from that shown. Reason: Frameshift at position 92.Curated
The sequence AAQ13514 differs from that shown. Reason: Frameshift at positions 404 and 424.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10G → R in AAL55770 (PubMed:15498874).Curated1
Sequence conflicti16 – 17EQ → DE in AAF67649 (PubMed:10931946).Curated2
Sequence conflicti17Q → T in AAF28981 (Ref. 2) Curated1
Sequence conflicti26D → G in AAL55770 (PubMed:15498874).Curated1
Sequence conflicti37A → T in AAL55770 (PubMed:15498874).Curated1
Sequence conflicti77E → D in AAF28981 (Ref. 2) Curated1
Sequence conflicti77E → D in AAF67649 (PubMed:10931946).Curated1
Sequence conflicti112Q → R in BAA91968 (PubMed:14702039).Curated1
Sequence conflicti342V → A in AAF28981 (Ref. 2) Curated1
Sequence conflicti365N → T in AAF28981 (Ref. 2) Curated1
Sequence conflicti413D → V in AAQ13514 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_039867342V → E.Corresponds to variant rs11555006dbSNPEnsembl.1
Natural variantiVAR_052969408T → P.Corresponds to variant rs1043497dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0559921 – 205Missing in isoform 2. 1 PublicationAdd BLAST205
Alternative sequenceiVSP_055993324 – 367DDSVS…DENKL → RGSFVPHLLMLIERNNRKYH NMVKSHQHQSHSAWVQILTP TMGN in isoform 2. 1 PublicationAdd BLAST44
Alternative sequenceiVSP_055994368 – 426Missing in isoform 2. 1 PublicationAdd BLAST59

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF109366 mRNA. Translation: AAQ13514.1. Frameshift.
AF161421 mRNA. Translation: AAF28981.1. Frameshift.
AF220184 mRNA. Translation: AAF67649.1. Frameshift.
AK001901 mRNA. Translation: BAA91968.1.
AK297658 mRNA. Translation: BAG60024.1.
AF289586 mRNA. Translation: AAL55770.1. Frameshift.
AC018867 Genomic DNA. Translation: AAX88885.1.
CH471058 Genomic DNA. Translation: EAX10935.1.
CH471058 Genomic DNA. Translation: EAX10936.1.
BC021102 mRNA. Translation: AAH21102.1.
CCDSiCCDS42791.1. [Q8WU90-1]
RefSeqiNP_060941.2. NM_018471.2. [Q8WU90-1]
UniGeneiHs.741180.

Genome annotation databases

EnsembliENST00000337859; ENSP00000338788; ENSG00000065548. [Q8WU90-1]
GeneIDi55854.
KEGGihsa:55854.
UCSCiuc002upo.4. human. [Q8WU90-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF109366 mRNA. Translation: AAQ13514.1. Frameshift.
AF161421 mRNA. Translation: AAF28981.1. Frameshift.
AF220184 mRNA. Translation: AAF67649.1. Frameshift.
AK001901 mRNA. Translation: BAA91968.1.
AK297658 mRNA. Translation: BAG60024.1.
AF289586 mRNA. Translation: AAL55770.1. Frameshift.
AC018867 Genomic DNA. Translation: AAX88885.1.
CH471058 Genomic DNA. Translation: EAX10935.1.
CH471058 Genomic DNA. Translation: EAX10936.1.
BC021102 mRNA. Translation: AAH21102.1.
CCDSiCCDS42791.1. [Q8WU90-1]
RefSeqiNP_060941.2. NM_018471.2. [Q8WU90-1]
UniGeneiHs.741180.

3D structure databases

ProteinModelPortaliQ8WU90.
SMRiQ8WU90.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120956. 39 interactors.
IntActiQ8WU90. 17 interactors.
MINTiMINT-4929572.
STRINGi9606.ENSP00000338788.

PTM databases

iPTMnetiQ8WU90.
PhosphoSitePlusiQ8WU90.

Polymorphism and mutation databases

BioMutaiZC3H15.
DMDMi74730681.

Proteomic databases

EPDiQ8WU90.
MaxQBiQ8WU90.
PaxDbiQ8WU90.
PeptideAtlasiQ8WU90.
PRIDEiQ8WU90.

Protocols and materials databases

DNASUi55854.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000337859; ENSP00000338788; ENSG00000065548. [Q8WU90-1]
GeneIDi55854.
KEGGihsa:55854.
UCSCiuc002upo.4. human. [Q8WU90-1]

Organism-specific databases

CTDi55854.
DisGeNETi55854.
GeneCardsiZC3H15.
H-InvDBHIX0002656.
HIX0161910.
HGNCiHGNC:29528. ZC3H15.
HPAiHPA031099.
HPA031100.
HPA031101.
neXtProtiNX_Q8WU90.
OpenTargetsiENSG00000065548.
PharmGKBiPA162409508.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1763. Eukaryota.
COG5252. LUCA.
GeneTreeiENSGT00390000015818.
HOVERGENiHBG108761.
InParanoidiQ8WU90.
OMAiHDLSMER.
OrthoDBiEOG091G0DYW.
PhylomeDBiQ8WU90.
TreeFamiTF300892.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000065548-MONOMER.

Miscellaneous databases

ChiTaRSiZC3H15. human.
GenomeRNAii55854.
PROiQ8WU90.

Gene expression databases

BgeeiENSG00000065548.
CleanExiHS_ZC3H15.
ExpressionAtlasiQ8WU90. baseline and differential.
GenevisibleiQ8WU90. HS.

Family and domain databases

Gene3Di4.10.1000.10. 1 hit.
InterProiIPR032378. ZC3H15/TMA46_C.
IPR000571. Znf_CCCH.
[Graphical view]
PfamiPF16543. DFRP_C. 1 hit.
PF00642. zf-CCCH. 1 hit.
[Graphical view]
SMARTiSM00356. ZnF_C3H1. 2 hits.
[Graphical view]
SUPFAMiSSF90229. SSF90229. 1 hit.
PROSITEiPS50103. ZF_C3H1. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZC3HF_HUMAN
AccessioniPrimary (citable) accession number: Q8WU90
Secondary accession number(s): B4DMW2
, D3DPG7, Q5QTQ4, Q8WZ06, Q9NUZ3, Q9NZ37, Q9P079
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 1, 2002
Last modified: November 30, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.