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Q8WU76 (SCFD2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sec1 family domain-containing protein 2
Alternative name(s):
Syntaxin-binding protein 1-like 1
Gene names
Name:SCFD2
Synonyms:STXBP1L1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length684 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be involved in protein transport.

Sequence similarities

Belongs to the STXBP/unc-18/SEC1 family.

Ontologies

Keywords
   Biological processProtein transport
Transport
   Coding sequence diversityAlternative splicing
Polymorphism
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processprotein transport

Inferred from electronic annotation. Source: UniProtKB-KW

vesicle docking involved in exocytosis

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8WU76-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8WU76-2)

The sequence of this isoform differs from the canonical sequence as follows:
     570-614: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 684684Sec1 family domain-containing protein 2
PRO_0000206290

Regions

Compositional bias120 – 1245Poly-Ala

Natural variations

Alternative sequence570 – 61445Missing in isoform 2.
VSP_010710
Natural variant5121L → S.
Corresponds to variant rs7675987 [ dbSNP | Ensembl ].
VAR_024687

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 1, 2004. Version 2.
Checksum: 8CD37FAF22801CB8

FASTA68475,127
        10         20         30         40         50         60 
MSASGVLSFT QQGWEQVLAK VKRAVVYLDA ACAESLHWGC GSTRLLEAVG GPDCHLREFE 

        70         80         90        100        110        120 
PDAIGGGAKQ PKAVFVLSCL LKGRTVEILR DIICRSHFQY CVVVTTVSHA VHLTANHVPA 

       130        140        150        160        170        180 
AAAAEMEGQQ PVFEQLEEKL CEWMGNMNYT AEVFHVPLLL APVAPHFALT PAFASLFPLL 

       190        200        210        220        230        240 
PQDVHLLNSA RPDKRKLGSL GDVDSTTLTP ELLLQIRCLV SGLSSLCEHL GVREECFAVG 

       250        260        270        280        290        300 
SLSQVIAADL ANYAPAKNRK KTAAGRASVV FVDRTLDLTG AVGHHGDNLV EKIISALPQL 

       310        320        330        340        350        360 
PGHTNDVMVN MIALTALHTE EENYNVVAPG CLSQSSDTTA KALWEALLNT KHKEAVMEVR 

       370        380        390        400        410        420 
RHLVEAASRE NLPIKMSMGR VTPGQLMSYI QLFKNNLKAL MNHCGLLQLG LATAQTLKHP 

       430        440        450        460        470        480 
QTAKWDNFLA FERLLLQSIG ESAMSVVLNQ LLPMIKPVTQ RTNEDYSPEE LLILLIYIYS 

       490        500        510        520        530        540 
VTGELTVDKD LCEAEEKVKK ALAQVFCEES GLSPLLQKIT DWDSSINLTF HKSKIAVDEL 

       550        560        570        580        590        600 
FTSLRDIAGA RSLLKQFKSV YVPGNHTHQA SYKPLLKQVV EEIFHPERPD SVDIEHMSSG 

       610        620        630        640        650        660 
LTDLLKTGFS MFMKVSRPHP SDYPLLILFV VGGVTVSEVK MVKDLVASLK PGTQVIVLST 

       670        680 
RLLKPLNIPE LLFATDRLHP DLGF 

« Hide

Isoform 2 [UniParc].

Checksum: 7997FAD29ABB1BD0
Show »

FASTA63969,992

References

« Hide 'large scale' references
[1]"Expression of a syntaxin binding protein 1-like gene in human neuroblastoma."
Weber A., Glaum A., Klinkhammer B., Bergmann E., Berwanger B., Eilers M., Christiansen H.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Fetal brain.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Endothelial cell.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain, Colon, Lung and Ovary.
[4]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[5]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY299407 mRNA. Translation: AAP57259.1.
AK096833 mRNA. Translation: BAC04872.1.
BC012458 mRNA. Translation: AAH12458.1.
BC021137 mRNA. Translation: AAH21137.2.
BC032453 mRNA. Translation: AAH32453.1.
RefSeqNP_689753.2. NM_152540.3.
UniGeneHs.302287.

3D structure databases

ProteinModelPortalQ8WU76.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid127454. 3 interactions.
IntActQ8WU76. 1 interaction.
STRING9606.ENSP00000384182.

PTM databases

PhosphoSiteQ8WU76.

Polymorphism databases

DMDM51338675.

Proteomic databases

PaxDbQ8WU76.
PRIDEQ8WU76.

Protocols and materials databases

DNASU152579.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000388940; ENSP00000373592; ENSG00000184178. [Q8WU76-2]
ENST00000401642; ENSP00000384182; ENSG00000184178. [Q8WU76-1]
GeneID152579.
KEGGhsa:152579.
UCSCuc003gzu.3. human. [Q8WU76-1]
uc010igm.3. human. [Q8WU76-2]

Organism-specific databases

CTD152579.
GeneCardsGC04M053739.
HGNCHGNC:30676. SCFD2.
HPAHPA036526.
neXtProtNX_Q8WU76.
PharmGKBPA134953686.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG75473.
HOGENOMHOG000234008.
HOVERGENHBG055096.
InParanoidQ8WU76.
OMALQKITGC.
OrthoDBEOG7WX07R.
PhylomeDBQ8WU76.
TreeFamTF329842.

Gene expression databases

ArrayExpressQ8WU76.
BgeeQ8WU76.
CleanExHS_SCFD2.
GenevestigatorQ8WU76.

Family and domain databases

Gene3D3.40.50.1910. 2 hits.
InterProIPR027482. Sec-1-like_dom2.
IPR001619. Sec1-like.
[Graphical view]
PANTHERPTHR11679. PTHR11679. 1 hit.
PfamPF00995. Sec1. 1 hit.
[Graphical view]
SUPFAMSSF56815. SSF56815. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi152579.
NextBio86992.
PROQ8WU76.

Entry information

Entry nameSCFD2_HUMAN
AccessionPrimary (citable) accession number: Q8WU76
Secondary accession number(s): Q8N5F3, Q8N8H0, Q96ED3
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: March 1, 2004
Last modified: April 16, 2014
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM