Q8WU76 (SCFD2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sec1 family domain-containing protein 2

Alternative name(s):
Syntaxin-binding protein 1-like 1

Gene names

Name:	SCFD2
Synonyms:	STXBP1L1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	684 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be involved in protein transport.
Sequence similarities	Belongs to the STXBP/unc-18/SEC1 family.

Ontologies

Keywords
Biological process	Protein transport Transport
Coding sequence diversity	Alternative splicing Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	protein transport Inferred from electronic annotation. Source: UniProtKB-KW vesicle docking involved in exocytosis Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8WU76-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8WU76-2)

The sequence of this isoform differs from the canonical sequence as follows:
     570-614: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 684	684	Sec1 family domain-containing protein 2		PRO_0000206290
Regions
	Compositional bias	120 – 124	5	Poly-Ala
Natural variations
	Alternative sequence	570 – 614	45	Missing in isoform 2.		VSP_010710
	Natural variant	512	1	L → S. Corresponds to variant rs7675987 [ dbSNP | Ensembl ].		VAR_024687

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 1, 2004. Version 2. Checksum: 8CD37FAF22801CB8	FASTA	684	75,127
	10 20 30 40 50 60 MSASGVLSFT QQGWEQVLAK VKRAVVYLDA ACAESLHWGC GSTRLLEAVG GPDCHLREFE 70 80 90 100 110 120 PDAIGGGAKQ PKAVFVLSCL LKGRTVEILR DIICRSHFQY CVVVTTVSHA VHLTANHVPA 130 140 150 160 170 180 AAAAEMEGQQ PVFEQLEEKL CEWMGNMNYT AEVFHVPLLL APVAPHFALT PAFASLFPLL 190 200 210 220 230 240 PQDVHLLNSA RPDKRKLGSL GDVDSTTLTP ELLLQIRCLV SGLSSLCEHL GVREECFAVG 250 260 270 280 290 300 SLSQVIAADL ANYAPAKNRK KTAAGRASVV FVDRTLDLTG AVGHHGDNLV EKIISALPQL 310 320 330 340 350 360 PGHTNDVMVN MIALTALHTE EENYNVVAPG CLSQSSDTTA KALWEALLNT KHKEAVMEVR 370 380 390 400 410 420 RHLVEAASRE NLPIKMSMGR VTPGQLMSYI QLFKNNLKAL MNHCGLLQLG LATAQTLKHP 430 440 450 460 470 480 QTAKWDNFLA FERLLLQSIG ESAMSVVLNQ LLPMIKPVTQ RTNEDYSPEE LLILLIYIYS 490 500 510 520 530 540 VTGELTVDKD LCEAEEKVKK ALAQVFCEES GLSPLLQKIT DWDSSINLTF HKSKIAVDEL 550 560 570 580 590 600 FTSLRDIAGA RSLLKQFKSV YVPGNHTHQA SYKPLLKQVV EEIFHPERPD SVDIEHMSSG 610 620 630 640 650 660 LTDLLKTGFS MFMKVSRPHP SDYPLLILFV VGGVTVSEVK MVKDLVASLK PGTQVIVLST 670 680 RLLKPLNIPE LLFATDRLHP DLGF
	Isoform 2 [UniParc]. Checksum: 7997FAD29ABB1BD0	FASTA	639	69,992
	10 20 30 40 50 60 MSASGVLSFT QQGWEQVLAK VKRAVVYLDA ACAESLHWGC GSTRLLEAVG GPDCHLREFE 70 80 90 100 110 120 PDAIGGGAKQ PKAVFVLSCL LKGRTVEILR DIICRSHFQY CVVVTTVSHA VHLTANHVPA 130 140 150 160 170 180 AAAAEMEGQQ PVFEQLEEKL CEWMGNMNYT AEVFHVPLLL APVAPHFALT PAFASLFPLL 190 200 210 220 230 240 PQDVHLLNSA RPDKRKLGSL GDVDSTTLTP ELLLQIRCLV SGLSSLCEHL GVREECFAVG 250 260 270 280 290 300 SLSQVIAADL ANYAPAKNRK KTAAGRASVV FVDRTLDLTG AVGHHGDNLV EKIISALPQL 310 320 330 340 350 360 PGHTNDVMVN MIALTALHTE EENYNVVAPG CLSQSSDTTA KALWEALLNT KHKEAVMEVR 370 380 390 400 410 420 RHLVEAASRE NLPIKMSMGR VTPGQLMSYI QLFKNNLKAL MNHCGLLQLG LATAQTLKHP 430 440 450 460 470 480 QTAKWDNFLA FERLLLQSIG ESAMSVVLNQ LLPMIKPVTQ RTNEDYSPEE LLILLIYIYS 490 500 510 520 530 540 VTGELTVDKD LCEAEEKVKK ALAQVFCEES GLSPLLQKIT DWDSSINLTF HKSKIAVDEL 550 560 570 580 590 600 FTSLRDIAGA RSLLKQFKSV YVPGNHTHQV SRPHPSDYPL LILFVVGGVT VSEVKMVKDL 610 620 630 VASLKPGTQV IVLSTRLLKP LNIPELLFAT DRLHPDLGF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Expression of a syntaxin binding protein 1-like gene in human neuroblastoma." Weber A., Glaum A., Klinkhammer B., Bergmann E., Berwanger B., Eilers M., Christiansen H. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Fetal brain.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Endothelial cell.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain, Colon, Lung and Ovary.
[4]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[5]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY299407 mRNA. Translation: AAP57259.1. AK096833 mRNA. Translation: BAC04872.1. BC012458 mRNA. Translation: AAH12458.1. BC021137 mRNA. Translation: AAH21137.2. BC032453 mRNA. Translation: AAH32453.1.
IPI	IPI00141564. IPI00419891.
RefSeq	NP_689753.2. NM_152540.3.
UniGene	Hs.302287.
3D structure databases
ProteinModelPortal	Q8WU76.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8WU76. 1 interaction.
PTM databases
PhosphoSite	Q8WU76.
Polymorphism databases
DMDM	51338675.
Proteomic databases
PaxDb	Q8WU76.
PRIDE	Q8WU76.
Protocols and materials databases
DNASU	152579.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000388940; ENSP00000373592; ENSG00000184178. ENST00000401642; ENSP00000384182; ENSG00000184178.
GeneID	152579.
KEGG	hsa:152579.
UCSC	uc003gzu.3. human. uc010igm.3. human.
Organism-specific databases
CTD	152579.
GeneCards	GC04M053739.
HGNC	HGNC:30676. SCFD2.
HPA	HPA036526.
neXtProt	NX_Q8WU76.
PharmGKB	PA134953686.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG75473.
HOGENOM	HOG000234008.
HOVERGEN	HBG055096.
InParanoid	Q8WU76.
OMA	VKRAVVY.
OrthoDB	EOG4HHP3N.
Gene expression databases
ArrayExpress	Q8WU76.
Bgee	Q8WU76.
CleanEx	HS_SCFD2.
Genevestigator	Q8WU76.
GermOnline	ENSG00000184178. Homo sapiens.
Family and domain databases
InterPro	IPR001619. Sec1-like. [Graphical view]
PANTHER	PTHR11679. PTHR11679. 1 hit.
Pfam	PF00995. Sec1. 1 hit. [Graphical view]
SUPFAM	SSF56815. Sec1-like. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	152579.
NextBio	86992.

Entry information

Entry name

SCFD2_HUMAN

Accession

Primary (citable) accession number: Q8WU76
Secondary accession number(s): Q8N5F3, Q8N8H0, Q96ED3

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 5, 2004
Last sequence update:	March 1, 2004
Last modified:	March 6, 2013
This is version 82 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.