Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Sec1 family domain-containing protein 2

Gene

SCFD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in protein transport.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Sec1 family domain-containing protein 2
Alternative name(s):
Syntaxin-binding protein 1-like 1
Gene namesi
Name:SCFD2
Synonyms:STXBP1L1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:30676. SCFD2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134953686.

Polymorphism and mutation databases

BioMutaiSCFD2.
DMDMi51338675.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 684684Sec1 family domain-containing protein 2PRO_0000206290Add
BLAST

Proteomic databases

MaxQBiQ8WU76.
PaxDbiQ8WU76.
PRIDEiQ8WU76.

PTM databases

PhosphoSiteiQ8WU76.

Expressioni

Gene expression databases

BgeeiQ8WU76.
CleanExiHS_SCFD2.
ExpressionAtlasiQ8WU76. baseline and differential.
GenevisibleiQ8WU76. HS.

Organism-specific databases

HPAiHPA036526.
HPA036527.

Interactioni

Protein-protein interaction databases

BioGridi127454. 14 interactions.
IntActiQ8WU76. 1 interaction.
STRINGi9606.ENSP00000384182.

Structurei

3D structure databases

ProteinModelPortaliQ8WU76.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi120 – 1245Poly-Ala

Sequence similaritiesi

Belongs to the STXBP/unc-18/SEC1 family.Curated

Phylogenomic databases

eggNOGiNOG75473.
GeneTreeiENSGT00390000011192.
HOGENOMiHOG000234008.
HOVERGENiHBG055096.
InParanoidiQ8WU76.
OMAiHTEEENY.
OrthoDBiEOG7WX07R.
PhylomeDBiQ8WU76.
TreeFamiTF329842.

Family and domain databases

Gene3Di3.40.50.1910. 2 hits.
InterProiIPR027482. Sec-1-like_dom2.
IPR001619. Sec1-like.
[Graphical view]
PANTHERiPTHR11679. PTHR11679. 1 hit.
PfamiPF00995. Sec1. 1 hit.
[Graphical view]
SUPFAMiSSF56815. SSF56815. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WU76-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSASGVLSFT QQGWEQVLAK VKRAVVYLDA ACAESLHWGC GSTRLLEAVG
60 70 80 90 100
GPDCHLREFE PDAIGGGAKQ PKAVFVLSCL LKGRTVEILR DIICRSHFQY
110 120 130 140 150
CVVVTTVSHA VHLTANHVPA AAAAEMEGQQ PVFEQLEEKL CEWMGNMNYT
160 170 180 190 200
AEVFHVPLLL APVAPHFALT PAFASLFPLL PQDVHLLNSA RPDKRKLGSL
210 220 230 240 250
GDVDSTTLTP ELLLQIRCLV SGLSSLCEHL GVREECFAVG SLSQVIAADL
260 270 280 290 300
ANYAPAKNRK KTAAGRASVV FVDRTLDLTG AVGHHGDNLV EKIISALPQL
310 320 330 340 350
PGHTNDVMVN MIALTALHTE EENYNVVAPG CLSQSSDTTA KALWEALLNT
360 370 380 390 400
KHKEAVMEVR RHLVEAASRE NLPIKMSMGR VTPGQLMSYI QLFKNNLKAL
410 420 430 440 450
MNHCGLLQLG LATAQTLKHP QTAKWDNFLA FERLLLQSIG ESAMSVVLNQ
460 470 480 490 500
LLPMIKPVTQ RTNEDYSPEE LLILLIYIYS VTGELTVDKD LCEAEEKVKK
510 520 530 540 550
ALAQVFCEES GLSPLLQKIT DWDSSINLTF HKSKIAVDEL FTSLRDIAGA
560 570 580 590 600
RSLLKQFKSV YVPGNHTHQA SYKPLLKQVV EEIFHPERPD SVDIEHMSSG
610 620 630 640 650
LTDLLKTGFS MFMKVSRPHP SDYPLLILFV VGGVTVSEVK MVKDLVASLK
660 670 680
PGTQVIVLST RLLKPLNIPE LLFATDRLHP DLGF
Length:684
Mass (Da):75,127
Last modified:March 1, 2004 - v2
Checksum:i8CD37FAF22801CB8
GO
Isoform 2 (identifier: Q8WU76-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     570-614: Missing.

Note: No experimental confirmation available.
Show »
Length:639
Mass (Da):69,992
Checksum:i7997FAD29ABB1BD0
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti512 – 5121L → S.
Corresponds to variant rs7675987 [ dbSNP | Ensembl ].
VAR_024687

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei570 – 61445Missing in isoform 2. 1 PublicationVSP_010710Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY299407 mRNA. Translation: AAP57259.1.
AK096833 mRNA. Translation: BAC04872.1.
BC012458 mRNA. Translation: AAH12458.1.
BC021137 mRNA. Translation: AAH21137.2.
BC032453 mRNA. Translation: AAH32453.1.
CCDSiCCDS33984.1. [Q8WU76-1]
RefSeqiNP_689753.2. NM_152540.3. [Q8WU76-1]
UniGeneiHs.302287.

Genome annotation databases

EnsembliENST00000388940; ENSP00000373592; ENSG00000184178. [Q8WU76-2]
ENST00000401642; ENSP00000384182; ENSG00000184178.
GeneIDi152579.
KEGGihsa:152579.
UCSCiuc003gzu.3. human. [Q8WU76-1]
uc010igm.3. human. [Q8WU76-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY299407 mRNA. Translation: AAP57259.1.
AK096833 mRNA. Translation: BAC04872.1.
BC012458 mRNA. Translation: AAH12458.1.
BC021137 mRNA. Translation: AAH21137.2.
BC032453 mRNA. Translation: AAH32453.1.
CCDSiCCDS33984.1. [Q8WU76-1]
RefSeqiNP_689753.2. NM_152540.3. [Q8WU76-1]
UniGeneiHs.302287.

3D structure databases

ProteinModelPortaliQ8WU76.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127454. 14 interactions.
IntActiQ8WU76. 1 interaction.
STRINGi9606.ENSP00000384182.

PTM databases

PhosphoSiteiQ8WU76.

Polymorphism and mutation databases

BioMutaiSCFD2.
DMDMi51338675.

Proteomic databases

MaxQBiQ8WU76.
PaxDbiQ8WU76.
PRIDEiQ8WU76.

Protocols and materials databases

DNASUi152579.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000388940; ENSP00000373592; ENSG00000184178. [Q8WU76-2]
ENST00000401642; ENSP00000384182; ENSG00000184178.
GeneIDi152579.
KEGGihsa:152579.
UCSCiuc003gzu.3. human. [Q8WU76-1]
uc010igm.3. human. [Q8WU76-2]

Organism-specific databases

CTDi152579.
GeneCardsiGC04M053739.
HGNCiHGNC:30676. SCFD2.
HPAiHPA036526.
HPA036527.
neXtProtiNX_Q8WU76.
PharmGKBiPA134953686.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG75473.
GeneTreeiENSGT00390000011192.
HOGENOMiHOG000234008.
HOVERGENiHBG055096.
InParanoidiQ8WU76.
OMAiHTEEENY.
OrthoDBiEOG7WX07R.
PhylomeDBiQ8WU76.
TreeFamiTF329842.

Miscellaneous databases

ChiTaRSiSCFD2. human.
GenomeRNAii152579.
NextBioi86992.
PROiQ8WU76.

Gene expression databases

BgeeiQ8WU76.
CleanExiHS_SCFD2.
ExpressionAtlasiQ8WU76. baseline and differential.
GenevisibleiQ8WU76. HS.

Family and domain databases

Gene3Di3.40.50.1910. 2 hits.
InterProiIPR027482. Sec-1-like_dom2.
IPR001619. Sec1-like.
[Graphical view]
PANTHERiPTHR11679. PTHR11679. 1 hit.
PfamiPF00995. Sec1. 1 hit.
[Graphical view]
SUPFAMiSSF56815. SSF56815. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Expression of a syntaxin binding protein 1-like gene in human neuroblastoma."
    Weber A., Glaum A., Klinkhammer B., Bergmann E., Berwanger B., Eilers M., Christiansen H.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Fetal brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Endothelial cell.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain, Colon, Lung and Ovary.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSCFD2_HUMAN
AccessioniPrimary (citable) accession number: Q8WU76
Secondary accession number(s): Q8N5F3, Q8N8H0, Q96ED3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: March 1, 2004
Last modified: July 22, 2015
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.