Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8WU76

- SCFD2_HUMAN

UniProt

Q8WU76 - SCFD2_HUMAN

Protein

Sec1 family domain-containing protein 2

Gene

SCFD2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 2 (01 Mar 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    May be involved in protein transport.

    GO - Biological processi

    1. protein transport Source: UniProtKB-KW
    2. vesicle docking involved in exocytosis Source: InterPro

    Keywords - Biological processi

    Protein transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sec1 family domain-containing protein 2
    Alternative name(s):
    Syntaxin-binding protein 1-like 1
    Gene namesi
    Name:SCFD2
    Synonyms:STXBP1L1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:30676. SCFD2.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134953686.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 684684Sec1 family domain-containing protein 2PRO_0000206290Add
    BLAST

    Proteomic databases

    MaxQBiQ8WU76.
    PaxDbiQ8WU76.
    PRIDEiQ8WU76.

    PTM databases

    PhosphoSiteiQ8WU76.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8WU76.
    BgeeiQ8WU76.
    CleanExiHS_SCFD2.
    GenevestigatoriQ8WU76.

    Organism-specific databases

    HPAiHPA036526.

    Interactioni

    Protein-protein interaction databases

    BioGridi127454. 4 interactions.
    IntActiQ8WU76. 1 interaction.
    STRINGi9606.ENSP00000384182.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8WU76.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi120 – 1245Poly-Ala

    Sequence similaritiesi

    Belongs to the STXBP/unc-18/SEC1 family.Curated

    Phylogenomic databases

    eggNOGiNOG75473.
    HOGENOMiHOG000234008.
    HOVERGENiHBG055096.
    InParanoidiQ8WU76.
    OMAiLQKITGC.
    OrthoDBiEOG7WX07R.
    PhylomeDBiQ8WU76.
    TreeFamiTF329842.

    Family and domain databases

    Gene3Di3.40.50.1910. 2 hits.
    InterProiIPR027482. Sec-1-like_dom2.
    IPR001619. Sec1-like.
    [Graphical view]
    PANTHERiPTHR11679. PTHR11679. 1 hit.
    PfamiPF00995. Sec1. 1 hit.
    [Graphical view]
    SUPFAMiSSF56815. SSF56815. 1 hit.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8WU76-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSASGVLSFT QQGWEQVLAK VKRAVVYLDA ACAESLHWGC GSTRLLEAVG    50
    GPDCHLREFE PDAIGGGAKQ PKAVFVLSCL LKGRTVEILR DIICRSHFQY 100
    CVVVTTVSHA VHLTANHVPA AAAAEMEGQQ PVFEQLEEKL CEWMGNMNYT 150
    AEVFHVPLLL APVAPHFALT PAFASLFPLL PQDVHLLNSA RPDKRKLGSL 200
    GDVDSTTLTP ELLLQIRCLV SGLSSLCEHL GVREECFAVG SLSQVIAADL 250
    ANYAPAKNRK KTAAGRASVV FVDRTLDLTG AVGHHGDNLV EKIISALPQL 300
    PGHTNDVMVN MIALTALHTE EENYNVVAPG CLSQSSDTTA KALWEALLNT 350
    KHKEAVMEVR RHLVEAASRE NLPIKMSMGR VTPGQLMSYI QLFKNNLKAL 400
    MNHCGLLQLG LATAQTLKHP QTAKWDNFLA FERLLLQSIG ESAMSVVLNQ 450
    LLPMIKPVTQ RTNEDYSPEE LLILLIYIYS VTGELTVDKD LCEAEEKVKK 500
    ALAQVFCEES GLSPLLQKIT DWDSSINLTF HKSKIAVDEL FTSLRDIAGA 550
    RSLLKQFKSV YVPGNHTHQA SYKPLLKQVV EEIFHPERPD SVDIEHMSSG 600
    LTDLLKTGFS MFMKVSRPHP SDYPLLILFV VGGVTVSEVK MVKDLVASLK 650
    PGTQVIVLST RLLKPLNIPE LLFATDRLHP DLGF 684
    Length:684
    Mass (Da):75,127
    Last modified:March 1, 2004 - v2
    Checksum:i8CD37FAF22801CB8
    GO
    Isoform 2 (identifier: Q8WU76-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         570-614: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:639
    Mass (Da):69,992
    Checksum:i7997FAD29ABB1BD0
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti512 – 5121L → S.
    Corresponds to variant rs7675987 [ dbSNP | Ensembl ].
    VAR_024687

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei570 – 61445Missing in isoform 2. 1 PublicationVSP_010710Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY299407 mRNA. Translation: AAP57259.1.
    AK096833 mRNA. Translation: BAC04872.1.
    BC012458 mRNA. Translation: AAH12458.1.
    BC021137 mRNA. Translation: AAH21137.2.
    BC032453 mRNA. Translation: AAH32453.1.
    CCDSiCCDS33984.1. [Q8WU76-1]
    RefSeqiNP_689753.2. NM_152540.3. [Q8WU76-1]
    UniGeneiHs.302287.

    Genome annotation databases

    EnsembliENST00000388940; ENSP00000373592; ENSG00000184178. [Q8WU76-2]
    ENST00000401642; ENSP00000384182; ENSG00000184178. [Q8WU76-1]
    GeneIDi152579.
    KEGGihsa:152579.
    UCSCiuc003gzu.3. human. [Q8WU76-1]
    uc010igm.3. human. [Q8WU76-2]

    Polymorphism databases

    DMDMi51338675.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY299407 mRNA. Translation: AAP57259.1 .
    AK096833 mRNA. Translation: BAC04872.1 .
    BC012458 mRNA. Translation: AAH12458.1 .
    BC021137 mRNA. Translation: AAH21137.2 .
    BC032453 mRNA. Translation: AAH32453.1 .
    CCDSi CCDS33984.1. [Q8WU76-1 ]
    RefSeqi NP_689753.2. NM_152540.3. [Q8WU76-1 ]
    UniGenei Hs.302287.

    3D structure databases

    ProteinModelPortali Q8WU76.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 127454. 4 interactions.
    IntActi Q8WU76. 1 interaction.
    STRINGi 9606.ENSP00000384182.

    PTM databases

    PhosphoSitei Q8WU76.

    Polymorphism databases

    DMDMi 51338675.

    Proteomic databases

    MaxQBi Q8WU76.
    PaxDbi Q8WU76.
    PRIDEi Q8WU76.

    Protocols and materials databases

    DNASUi 152579.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000388940 ; ENSP00000373592 ; ENSG00000184178 . [Q8WU76-2 ]
    ENST00000401642 ; ENSP00000384182 ; ENSG00000184178 . [Q8WU76-1 ]
    GeneIDi 152579.
    KEGGi hsa:152579.
    UCSCi uc003gzu.3. human. [Q8WU76-1 ]
    uc010igm.3. human. [Q8WU76-2 ]

    Organism-specific databases

    CTDi 152579.
    GeneCardsi GC04M053739.
    HGNCi HGNC:30676. SCFD2.
    HPAi HPA036526.
    neXtProti NX_Q8WU76.
    PharmGKBi PA134953686.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG75473.
    HOGENOMi HOG000234008.
    HOVERGENi HBG055096.
    InParanoidi Q8WU76.
    OMAi LQKITGC.
    OrthoDBi EOG7WX07R.
    PhylomeDBi Q8WU76.
    TreeFami TF329842.

    Miscellaneous databases

    GenomeRNAii 152579.
    NextBioi 86992.
    PROi Q8WU76.

    Gene expression databases

    ArrayExpressi Q8WU76.
    Bgeei Q8WU76.
    CleanExi HS_SCFD2.
    Genevestigatori Q8WU76.

    Family and domain databases

    Gene3Di 3.40.50.1910. 2 hits.
    InterProi IPR027482. Sec-1-like_dom2.
    IPR001619. Sec1-like.
    [Graphical view ]
    PANTHERi PTHR11679. PTHR11679. 1 hit.
    Pfami PF00995. Sec1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56815. SSF56815. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Expression of a syntaxin binding protein 1-like gene in human neuroblastoma."
      Weber A., Glaum A., Klinkhammer B., Bergmann E., Berwanger B., Eilers M., Christiansen H.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Fetal brain.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Endothelial cell.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain, Colon, Lung and Ovary.
    4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSCFD2_HUMAN
    AccessioniPrimary (citable) accession number: Q8WU76
    Secondary accession number(s): Q8N5F3, Q8N8H0, Q96ED3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2004
    Last sequence update: March 1, 2004
    Last modified: October 1, 2014
    This is version 94 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3