Q8WU67 (ABHD3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Abhydrolase domain-containing protein 3
EC=3.1.1.-

Alternative name(s):
Lung alpha/beta hydrolase 3

Gene names

Name:	ABHD3
Synonyms:	LABH3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	409 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Single-pass type II membrane protein Potential.
Sequence similarities	Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.
Sequence caution	The sequence AAC19155.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Signal-anchor Transmembrane Transmembrane helix
Molecular function	Hydrolase Serine esterase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	carboxylesterase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 409	409	Abhydrolase domain-containing protein 3		PRO_0000280208
Regions
	Transmembrane	26 – 46	21	Helical; Signal-anchor for type II membrane protein; Potential
Sites
	Active site	220	1	Charge relay system By similarity
	Active site	346	1	Charge relay system By similarity
	Active site	375	1	Charge relay system By similarity
Natural variations
	Natural variant	3	1	R → C. Ref.4 Corresponds to variant rs17851878 [ dbSNP | Ensembl ].		VAR_031089

Sequences

	Sequence		Length	Mass (Da)
	Q8WU67 [UniParc]. Last modified March 20, 2007. Version 2. Checksum: 9A3920EB7528273B	FASTA	409	46,009
	10 20 30 40 50 60 MQRLAMDLRM LSRELSLYLE HQVRVGFFGS GVGLSLILGF SVAYAFYYLS SIAKKPQLVT 70 80 90 100 110 120 GGESFSRFLQ DHCPVVTETY YPTVWCWEGR GQTLLRPFIT SKPPVQYRNE LIKTADGGQI 130 140 150 160 170 180 SLDWFDNDNS TCYMDASTRP TILLLPGLTG TSKESYILHM IHLSEELGYR CVVFNNRGVA 190 200 210 220 230 240 GENLLTPRTY CCANTEDLET VIHHVHSLYP SAPFLAAGVS MGGMLLLNYL GKIGSKTPLM 250 260 270 280 290 300 AAATFSVGWN TFACSESLEK PLNWLLFNYY LTTCLQSSVN KHRHMFVKQV DMDHVMKAKS 310 320 330 340 350 360 IREFDKRFTS VMFGYQTIDD YYTDASPSPR LKSVGIPVLC LNSVDDVFSP SHAIPIETAK 370 380 390 400 QNPNVALVLT SYGGHIGFLE GIWPRQSTYM DRVFKQFVQA MVEHGHELS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Yu W., Sarginson J., Gibbs R.A. Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[2]	NHLBI resequencing and genotyping service (RS&G) Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT CYS-3. Tissue: Lung.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF007152 mRNA. Translation: AAC19155.1. Different initiation. EF444943 Genomic DNA. Translation: ACA05928.1. CH471088 Genomic DNA. Translation: EAX01131.1. BC021196 mRNA. Translation: AAH21196.1.
IPI	IPI00646051.
RefSeq	NP_612213.2. NM_138340.4.
UniGene	Hs.397978.
3D structure databases
ProteinModelPortal	Q8WU67.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8WU67. 1 interaction.
STRING	9606.ENSP00000289119.
PTM databases
PhosphoSite	Q8WU67.
Polymorphism databases
DMDM	134035377.
Proteomic databases
PaxDb	Q8WU67.
PRIDE	Q8WU67.
Protocols and materials databases
DNASU	171586.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000289119; ENSP00000289119; ENSG00000158201.
GeneID	171586.
KEGG	hsa:171586.
UCSC	uc002ktl.2. human.
Organism-specific databases
CTD	171586.
GeneCards	GC18M019230.
HGNC	HGNC:18718. ABHD3.
HPA	HPA010729.
MIM	612197. gene.
neXtProt	NX_Q8WU67.
PharmGKB	PA38659.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0429.
HOGENOM	HOG000230596.
HOVERGEN	HBG053994.
InParanoid	Q8WU67.
KO	K13696.
OMA	HVGFIEG.
OrthoDB	EOG44TP7W.
Gene expression databases
ArrayExpress	Q8WU67.
Bgee	Q8WU67.
CleanEx	HS_ABHD3.
Genevestigator	Q8WU67.
Family and domain databases
InterPro	IPR012020. AB-Hydro_YheT. IPR000952. UPF0017_hydro-like_CS. [Graphical view]
PIRSF	PIRSF005211. Ab_hydro_YheT. 1 hit.
PROSITE	PS01133. UPF0017. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	ABHD3. human.
GenomeRNAi	171586.
NextBio	89305.
SOURCE	Search...

Entry information

Entry name

ABHD3_HUMAN

Accession

Primary (citable) accession number: Q8WU67
Secondary accession number(s): B0YIV0, O43411

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
Last sequence update:	March 20, 2007
Last modified:	May 1, 2013
This is version 76 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.