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Q8WU67

- ABHD3_HUMAN

UniProt

Q8WU67 - ABHD3_HUMAN

Protein

Abhydrolase domain-containing protein 3

Gene

ABHD3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 2 (20 Mar 2007)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei220 – 2201Charge relay systemBy similarity
    Active sitei346 – 3461Charge relay systemBy similarity
    Active sitei375 – 3751Charge relay systemBy similarity

    GO - Molecular functioni

    1. hydrolase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Serine esterase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Abhydrolase domain-containing protein 3 (EC:3.1.1.-)
    Alternative name(s):
    Lung alpha/beta hydrolase 3
    Gene namesi
    Name:ABHD3
    Synonyms:LABH3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 18

    Organism-specific databases

    HGNCiHGNC:18718. ABHD3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38659.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 409409Abhydrolase domain-containing protein 3PRO_0000280208Add
    BLAST

    Proteomic databases

    MaxQBiQ8WU67.
    PaxDbiQ8WU67.
    PRIDEiQ8WU67.

    PTM databases

    PhosphoSiteiQ8WU67.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8WU67.
    BgeeiQ8WU67.
    CleanExiHS_ABHD3.
    GenevestigatoriQ8WU67.

    Organism-specific databases

    HPAiHPA010729.
    HPA052862.

    Interactioni

    Protein-protein interaction databases

    BioGridi128149. 1 interaction.
    IntActiQ8WU67. 1 interaction.
    STRINGi9606.ENSP00000289119.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8WU67.
    SMRiQ8WU67. Positions 136-251.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei26 – 4621Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0429.
    HOGENOMiHOG000230596.
    HOVERGENiHBG053994.
    InParanoidiQ8WU67.
    KOiK13696.
    OMAiHFRGASE.
    OrthoDBiEOG70PBXF.
    PhylomeDBiQ8WU67.
    TreeFamiTF313195.

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR012020. AB-Hydro_YheT.
    IPR029058. AB_hydrolase.
    IPR000952. UPF0017_hydro-like_CS.
    [Graphical view]
    PIRSFiPIRSF005211. Ab_hydro_YheT. 1 hit.
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS01133. UPF0017. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8WU67-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MQRLAMDLRM LSRELSLYLE HQVRVGFFGS GVGLSLILGF SVAYAFYYLS    50
    SIAKKPQLVT GGESFSRFLQ DHCPVVTETY YPTVWCWEGR GQTLLRPFIT 100
    SKPPVQYRNE LIKTADGGQI SLDWFDNDNS TCYMDASTRP TILLLPGLTG 150
    TSKESYILHM IHLSEELGYR CVVFNNRGVA GENLLTPRTY CCANTEDLET 200
    VIHHVHSLYP SAPFLAAGVS MGGMLLLNYL GKIGSKTPLM AAATFSVGWN 250
    TFACSESLEK PLNWLLFNYY LTTCLQSSVN KHRHMFVKQV DMDHVMKAKS 300
    IREFDKRFTS VMFGYQTIDD YYTDASPSPR LKSVGIPVLC LNSVDDVFSP 350
    SHAIPIETAK QNPNVALVLT SYGGHIGFLE GIWPRQSTYM DRVFKQFVQA 400
    MVEHGHELS 409
    Length:409
    Mass (Da):46,009
    Last modified:March 20, 2007 - v2
    Checksum:i9A3920EB7528273B
    GO
    Isoform 2 (identifier: Q8WU67-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         56-136: PQLVTGGESF...NDNSTCYMDA → RTTRRSGAGR...EQARSHISFI
         137-409: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:136
    Mass (Da):15,525
    Checksum:i61776799A97CA0A2
    GO

    Sequence cautioni

    The sequence AAC19155.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti3 – 31R → C.1 Publication
    Corresponds to variant rs17851878 [ dbSNP | Ensembl ].
    VAR_031089

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei56 – 13681PQLVT…CYMDA → RTTRRSGAGRVEDRPCLDLS SLRSPRCSTGMNLLKLQMED RFHWTGLIMITVRVIWMPAP DLLSYCCLASREQARSHISF I in isoform 2. 1 PublicationVSP_056137Add
    BLAST
    Alternative sequencei137 – 409273Missing in isoform 2. 1 PublicationVSP_056138Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF007152 mRNA. Translation: AAC19155.1. Different initiation.
    AK298728 mRNA. Translation: BAH12858.1.
    EF444943 Genomic DNA. Translation: ACA05928.1.
    AC106037 Genomic DNA. No translation available.
    CH471088 Genomic DNA. Translation: EAX01131.1.
    BC021196 mRNA. Translation: AAH21196.1.
    CCDSiCCDS32802.1.
    RefSeqiNP_612213.2. NM_138340.4.
    UniGeneiHs.397978.

    Genome annotation databases

    EnsembliENST00000289119; ENSP00000289119; ENSG00000158201.
    ENST00000577891; ENSP00000463365; ENSG00000158201.
    GeneIDi171586.
    KEGGihsa:171586.
    UCSCiuc002ktl.2. human.

    Polymorphism databases

    DMDMi134035377.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF007152 mRNA. Translation: AAC19155.1 . Different initiation.
    AK298728 mRNA. Translation: BAH12858.1 .
    EF444943 Genomic DNA. Translation: ACA05928.1 .
    AC106037 Genomic DNA. No translation available.
    CH471088 Genomic DNA. Translation: EAX01131.1 .
    BC021196 mRNA. Translation: AAH21196.1 .
    CCDSi CCDS32802.1.
    RefSeqi NP_612213.2. NM_138340.4.
    UniGenei Hs.397978.

    3D structure databases

    ProteinModelPortali Q8WU67.
    SMRi Q8WU67. Positions 136-251.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 128149. 1 interaction.
    IntActi Q8WU67. 1 interaction.
    STRINGi 9606.ENSP00000289119.

    PTM databases

    PhosphoSitei Q8WU67.

    Polymorphism databases

    DMDMi 134035377.

    Proteomic databases

    MaxQBi Q8WU67.
    PaxDbi Q8WU67.
    PRIDEi Q8WU67.

    Protocols and materials databases

    DNASUi 171586.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000289119 ; ENSP00000289119 ; ENSG00000158201 .
    ENST00000577891 ; ENSP00000463365 ; ENSG00000158201 .
    GeneIDi 171586.
    KEGGi hsa:171586.
    UCSCi uc002ktl.2. human.

    Organism-specific databases

    CTDi 171586.
    GeneCardsi GC18M019230.
    HGNCi HGNC:18718. ABHD3.
    HPAi HPA010729.
    HPA052862.
    MIMi 612197. gene.
    neXtProti NX_Q8WU67.
    PharmGKBi PA38659.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0429.
    HOGENOMi HOG000230596.
    HOVERGENi HBG053994.
    InParanoidi Q8WU67.
    KOi K13696.
    OMAi HFRGASE.
    OrthoDBi EOG70PBXF.
    PhylomeDBi Q8WU67.
    TreeFami TF313195.

    Miscellaneous databases

    ChiTaRSi ABHD3. human.
    GenomeRNAii 171586.
    NextBioi 89305.
    PROi Q8WU67.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8WU67.
    Bgeei Q8WU67.
    CleanExi HS_ABHD3.
    Genevestigatori Q8WU67.

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR012020. AB-Hydro_YheT.
    IPR029058. AB_hydrolase.
    IPR000952. UPF0017_hydro-like_CS.
    [Graphical view ]
    PIRSFi PIRSF005211. Ab_hydro_YheT. 1 hit.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS01133. UPF0017. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Yu W., Sarginson J., Gibbs R.A.
      Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    3. NHLBI resequencing and genotyping service (RS&G)
      Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT CYS-3.
      Tissue: Lung.

    Entry informationi

    Entry nameiABHD3_HUMAN
    AccessioniPrimary (citable) accession number: Q8WU67
    Secondary accession number(s): B0YIV0, B7Z5C2, O43411
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 20, 2007
    Last sequence update: March 20, 2007
    Last modified: October 1, 2014
    This is version 85 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 18
      Human chromosome 18: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3