Reviewed, UniProtKB/Swiss-Prot Q8WU67 (ABHD3_HUMAN)

Names and origin

Protein names

Recommended name:
    Abhydrolase domain-containing protein 3
    EC=3.1.1.-
Alternative name(s):
    Lung alpha/beta hydrolase 3

Gene names

Name:	ABHD3
Synonyms:	LABH3

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	409 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Subcellular location	Membrane; Single-pass type II membrane protein Potential.
Sequence similarities	Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Signal-anchor Transmembrane
Molecular function	Hydrolase Serine esterase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	carboxylesterase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 409	409	Abhydrolase domain-containing protein 3		PRO_0000280208
Regions
	Transmembrane	26 – 46	21	Signal-anchor for type II membrane protein Potential
Sites
	Active site	220	1	Charge relay system By similarity
	Active site	346	1	Charge relay system By similarity
	Active site	375	1	Charge relay system By similarity
Natural variations
	Natural variant	3	1	R → C: dbSNP rs17851878. Ref.4		VAR_031089

Sequences

	Sequence		Length	Mass (Da)
	Q8WU67-1 [UniParc]. Last modified March 20, 2007. Version 2. Checksum: 9A3920EB7528273B	FASTA	409	46,009
	10 20 30 40 50 60 MQRLAMDLRM LSRELSLYLE HQVRVGFFGS GVGLSLILGF SVAYAFYYLS SIAKKPQLVT 70 80 90 100 110 120 GGESFSRFLQ DHCPVVTETY YPTVWCWEGR GQTLLRPFIT SKPPVQYRNE LIKTADGGQI 130 140 150 160 170 180 SLDWFDNDNS TCYMDASTRP TILLLPGLTG TSKESYILHM IHLSEELGYR CVVFNNRGVA 190 200 210 220 230 240 GENLLTPRTY CCANTEDLET VIHHVHSLYP SAPFLAAGVS MGGMLLLNYL GKIGSKTPLM 250 260 270 280 290 300 AAATFSVGWN TFACSESLEK PLNWLLFNYY LTTCLQSSVN KHRHMFVKQV DMDHVMKAKS 310 320 330 340 350 360 IREFDKRFTS VMFGYQTIDD YYTDASPSPR LKSVGIPVLC LNSVDDVFSP SHAIPIETAK 370 380 390 400 QNPNVALVLT SYGGHIGFLE GIWPRQSTYM DRVFKQFVQA MVEHGHELS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Yu W., Sarginson J., Gibbs R.A. Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[2]	NHLBI resequencing and genotyping service (RS&G) Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT CYS-3. Tissue: Lung.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF007152 mRNA. Translation: AAC19155.1. Different initiation. EF444943 Genomic DNA. Translation: ACA05928.1. CH471088 Genomic DNA. Translation: EAX01131.1. BC021196 mRNA. Translation: AAH21196.1.
IPI	IPI00646051.
RefSeq	NP_612213.2.
UniGene	Hs.397978
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	Q8WU67.
Genome annotation databases
Ensembl	ENST00000289119; ENSP00000289119; ENSG00000158201; Homo sapiens. [Genome view]
GeneID	171586.
KEGG	hsa:171586.
UCSC	uc002ktl.1. human.
Organism-specific databases
CTD	171586.
GeneCards	GC18M017484.
HGNC	HGNC:18718. ABHD3.
HPA	HPA010729.
PharmGKB	PA38659.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q8WU67.
OMA	VHHHRSC
OrthoDB	EOG9258CM
Gene expression databases
ArrayExpress	Q8WU67.
Bgee	Q8WU67.
CleanEx	HS_ABHD3.
Genevestigator	Q8WU67.
Family and domain databases
InterPro	IPR012020. AB-Hydro_YheT. IPR000073. AB_hydrolase_1. IPR000952. UPF0017_hydro-like_CS. [Graphical view]
Pfam	PF00561. Abhydrolase_1. 1 hit. [Graphical view]
PIRSF	PIRSF005211. Ab_hydro_YheT. 1 hit.
PROSITE	PS01133. UPF0017. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	89305.

Entry information

Entry name

ABHD3_HUMAN

Accession

Primary (citable) accession number: Q8WU67
Secondary accession number(s): B0YIV0, O43411

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
Last sequence update:	March 20, 2007
Last modified:	November 24, 2009
This is version 49 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.