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Q8WU67

- ABHD3_HUMAN

UniProt

Q8WU67 - ABHD3_HUMAN

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Protein
Abhydrolase domain-containing protein 3
Gene
ABHD3, LABH3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei220 – 2201Charge relay system By similarity
Active sitei346 – 3461Charge relay system By similarity
Active sitei375 – 3751Charge relay system By similarity

GO - Molecular functioni

  1. hydrolase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Serine esterase

Names & Taxonomyi

Protein namesi
Recommended name:
Abhydrolase domain-containing protein 3 (EC:3.1.1.-)
Alternative name(s):
Lung alpha/beta hydrolase 3
Gene namesi
Name:ABHD3
Synonyms:LABH3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 18

Organism-specific databases

HGNCiHGNC:18718. ABHD3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei26 – 4621Helical; Signal-anchor for type II membrane protein; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38659.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 409409Abhydrolase domain-containing protein 3
PRO_0000280208Add
BLAST

Proteomic databases

MaxQBiQ8WU67.
PaxDbiQ8WU67.
PRIDEiQ8WU67.

PTM databases

PhosphoSiteiQ8WU67.

Expressioni

Gene expression databases

ArrayExpressiQ8WU67.
BgeeiQ8WU67.
CleanExiHS_ABHD3.
GenevestigatoriQ8WU67.

Organism-specific databases

HPAiHPA010729.
HPA052862.

Interactioni

Protein-protein interaction databases

BioGridi128149. 1 interaction.
IntActiQ8WU67. 1 interaction.
STRINGi9606.ENSP00000289119.

Structurei

3D structure databases

ProteinModelPortaliQ8WU67.
SMRiQ8WU67. Positions 136-251.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0429.
HOGENOMiHOG000230596.
HOVERGENiHBG053994.
InParanoidiQ8WU67.
KOiK13696.
OMAiHFRGASE.
OrthoDBiEOG70PBXF.
PhylomeDBiQ8WU67.
TreeFamiTF313195.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR012020. AB-Hydro_YheT.
IPR029058. AB_hydrolase.
IPR000952. UPF0017_hydro-like_CS.
[Graphical view]
PIRSFiPIRSF005211. Ab_hydro_YheT. 1 hit.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS01133. UPF0017. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WU67-1 [UniParc]FASTAAdd to Basket

« Hide

MQRLAMDLRM LSRELSLYLE HQVRVGFFGS GVGLSLILGF SVAYAFYYLS    50
SIAKKPQLVT GGESFSRFLQ DHCPVVTETY YPTVWCWEGR GQTLLRPFIT 100
SKPPVQYRNE LIKTADGGQI SLDWFDNDNS TCYMDASTRP TILLLPGLTG 150
TSKESYILHM IHLSEELGYR CVVFNNRGVA GENLLTPRTY CCANTEDLET 200
VIHHVHSLYP SAPFLAAGVS MGGMLLLNYL GKIGSKTPLM AAATFSVGWN 250
TFACSESLEK PLNWLLFNYY LTTCLQSSVN KHRHMFVKQV DMDHVMKAKS 300
IREFDKRFTS VMFGYQTIDD YYTDASPSPR LKSVGIPVLC LNSVDDVFSP 350
SHAIPIETAK QNPNVALVLT SYGGHIGFLE GIWPRQSTYM DRVFKQFVQA 400
MVEHGHELS 409
Length:409
Mass (Da):46,009
Last modified:March 20, 2007 - v2
Checksum:i9A3920EB7528273B
GO

Sequence cautioni

The sequence AAC19155.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti3 – 31R → C.1 Publication
Corresponds to variant rs17851878 [ dbSNP | Ensembl ].
VAR_031089

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF007152 mRNA. Translation: AAC19155.1. Different initiation.
EF444943 Genomic DNA. Translation: ACA05928.1.
CH471088 Genomic DNA. Translation: EAX01131.1.
BC021196 mRNA. Translation: AAH21196.1.
CCDSiCCDS32802.1.
RefSeqiNP_612213.2. NM_138340.4.
UniGeneiHs.397978.

Genome annotation databases

EnsembliENST00000289119; ENSP00000289119; ENSG00000158201.
GeneIDi171586.
KEGGihsa:171586.
UCSCiuc002ktl.2. human.

Polymorphism databases

DMDMi134035377.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF007152 mRNA. Translation: AAC19155.1 . Different initiation.
EF444943 Genomic DNA. Translation: ACA05928.1 .
CH471088 Genomic DNA. Translation: EAX01131.1 .
BC021196 mRNA. Translation: AAH21196.1 .
CCDSi CCDS32802.1.
RefSeqi NP_612213.2. NM_138340.4.
UniGenei Hs.397978.

3D structure databases

ProteinModelPortali Q8WU67.
SMRi Q8WU67. Positions 136-251.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 128149. 1 interaction.
IntActi Q8WU67. 1 interaction.
STRINGi 9606.ENSP00000289119.

PTM databases

PhosphoSitei Q8WU67.

Polymorphism databases

DMDMi 134035377.

Proteomic databases

MaxQBi Q8WU67.
PaxDbi Q8WU67.
PRIDEi Q8WU67.

Protocols and materials databases

DNASUi 171586.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000289119 ; ENSP00000289119 ; ENSG00000158201 .
GeneIDi 171586.
KEGGi hsa:171586.
UCSCi uc002ktl.2. human.

Organism-specific databases

CTDi 171586.
GeneCardsi GC18M019230.
HGNCi HGNC:18718. ABHD3.
HPAi HPA010729.
HPA052862.
MIMi 612197. gene.
neXtProti NX_Q8WU67.
PharmGKBi PA38659.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0429.
HOGENOMi HOG000230596.
HOVERGENi HBG053994.
InParanoidi Q8WU67.
KOi K13696.
OMAi HFRGASE.
OrthoDBi EOG70PBXF.
PhylomeDBi Q8WU67.
TreeFami TF313195.

Miscellaneous databases

ChiTaRSi ABHD3. human.
GenomeRNAii 171586.
NextBioi 89305.
PROi Q8WU67.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8WU67.
Bgeei Q8WU67.
CleanExi HS_ABHD3.
Genevestigatori Q8WU67.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR012020. AB-Hydro_YheT.
IPR029058. AB_hydrolase.
IPR000952. UPF0017_hydro-like_CS.
[Graphical view ]
PIRSFi PIRSF005211. Ab_hydro_YheT. 1 hit.
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS01133. UPF0017. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Yu W., Sarginson J., Gibbs R.A.
    Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. NHLBI resequencing and genotyping service (RS&G)
    Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT CYS-3.
    Tissue: Lung.

Entry informationi

Entry nameiABHD3_HUMAN
AccessioniPrimary (citable) accession number: Q8WU67
Secondary accession number(s): B0YIV0, O43411
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: July 9, 2014
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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