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Q8WU67 (ABHD3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Abhydrolase domain-containing protein 3

EC=3.1.1.-
Alternative name(s):
Lung alpha/beta hydrolase 3
Gene names
Name:ABHD3
Synonyms:LABH3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length409 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Single-pass type II membrane protein Potential.

Sequence similarities

Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.

Sequence caution

The sequence AAC19155.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityPolymorphism
   DomainSignal-anchor
Transmembrane
Transmembrane helix
   Molecular functionHydrolase
Serine esterase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionhydrolase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 409409Abhydrolase domain-containing protein 3
PRO_0000280208

Regions

Transmembrane26 – 4621Helical; Signal-anchor for type II membrane protein; Potential

Sites

Active site2201Charge relay system By similarity
Active site3461Charge relay system By similarity
Active site3751Charge relay system By similarity

Natural variations

Natural variant31R → C. Ref.4
Corresponds to variant rs17851878 [ dbSNP | Ensembl ].
VAR_031089

Sequences

Sequence LengthMass (Da)Tools
Q8WU67 [UniParc].

Last modified March 20, 2007. Version 2.
Checksum: 9A3920EB7528273B

FASTA40946,009
        10         20         30         40         50         60 
MQRLAMDLRM LSRELSLYLE HQVRVGFFGS GVGLSLILGF SVAYAFYYLS SIAKKPQLVT 

        70         80         90        100        110        120 
GGESFSRFLQ DHCPVVTETY YPTVWCWEGR GQTLLRPFIT SKPPVQYRNE LIKTADGGQI 

       130        140        150        160        170        180 
SLDWFDNDNS TCYMDASTRP TILLLPGLTG TSKESYILHM IHLSEELGYR CVVFNNRGVA 

       190        200        210        220        230        240 
GENLLTPRTY CCANTEDLET VIHHVHSLYP SAPFLAAGVS MGGMLLLNYL GKIGSKTPLM 

       250        260        270        280        290        300 
AAATFSVGWN TFACSESLEK PLNWLLFNYY LTTCLQSSVN KHRHMFVKQV DMDHVMKAKS 

       310        320        330        340        350        360 
IREFDKRFTS VMFGYQTIDD YYTDASPSPR LKSVGIPVLC LNSVDDVFSP SHAIPIETAK 

       370        380        390        400 
QNPNVALVLT SYGGHIGFLE GIWPRQSTYM DRVFKQFVQA MVEHGHELS 

« Hide

References

« Hide 'large scale' references
[1]Yu W., Sarginson J., Gibbs R.A.
Submitted (JUN-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[2]NHLBI resequencing and genotyping service (RS&G)
Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT CYS-3.
Tissue: Lung.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF007152 mRNA. Translation: AAC19155.1. Different initiation.
EF444943 Genomic DNA. Translation: ACA05928.1.
CH471088 Genomic DNA. Translation: EAX01131.1.
BC021196 mRNA. Translation: AAH21196.1.
CCDSCCDS32802.1.
RefSeqNP_612213.2. NM_138340.4.
UniGeneHs.397978.

3D structure databases

ProteinModelPortalQ8WU67.
SMRQ8WU67. Positions 136-251.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid128149. 1 interaction.
IntActQ8WU67. 1 interaction.
STRING9606.ENSP00000289119.

PTM databases

PhosphoSiteQ8WU67.

Polymorphism databases

DMDM134035377.

Proteomic databases

MaxQBQ8WU67.
PaxDbQ8WU67.
PRIDEQ8WU67.

Protocols and materials databases

DNASU171586.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000289119; ENSP00000289119; ENSG00000158201.
GeneID171586.
KEGGhsa:171586.
UCSCuc002ktl.2. human.

Organism-specific databases

CTD171586.
GeneCardsGC18M019230.
HGNCHGNC:18718. ABHD3.
HPAHPA010729.
HPA052862.
MIM612197. gene.
neXtProtNX_Q8WU67.
PharmGKBPA38659.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0429.
HOGENOMHOG000230596.
HOVERGENHBG053994.
InParanoidQ8WU67.
KOK13696.
OMAHFRGASE.
OrthoDBEOG70PBXF.
PhylomeDBQ8WU67.
TreeFamTF313195.

Gene expression databases

ArrayExpressQ8WU67.
BgeeQ8WU67.
CleanExHS_ABHD3.
GenevestigatorQ8WU67.

Family and domain databases

Gene3D3.40.50.1820. 1 hit.
InterProIPR012020. AB-Hydro_YheT.
IPR029058. AB_hydrolase.
IPR000952. UPF0017_hydro-like_CS.
[Graphical view]
PIRSFPIRSF005211. Ab_hydro_YheT. 1 hit.
SUPFAMSSF53474. SSF53474. 1 hit.
PROSITEPS01133. UPF0017. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSABHD3. human.
GenomeRNAi171586.
NextBio89305.
PROQ8WU67.
SOURCESearch...

Entry information

Entry nameABHD3_HUMAN
AccessionPrimary (citable) accession number: Q8WU67
Secondary accession number(s): B0YIV0, O43411
Entry history
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 20, 2007
Last modified: July 9, 2014
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 18

Human chromosome 18: entries, gene names and cross-references to MIM