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Protein

Protein FAM222B

Gene

FAM222B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

SignaLinkiQ8WU58.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM222B
Gene namesi
Name:FAM222B
Synonyms:C17orf63
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:25563. FAM222B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672246.

Polymorphism and mutation databases

DMDMi74730670.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 562562Protein FAM222BPRO_0000274245Add
BLAST

Proteomic databases

PaxDbiQ8WU58.
PRIDEiQ8WU58.

PTM databases

PhosphoSiteiQ8WU58.

Expressioni

Gene expression databases

BgeeiQ8WU58.
CleanExiHS_C17orf63.
ExpressionAtlasiQ8WU58. baseline and differential.
GenevestigatoriQ8WU58.

Organism-specific databases

HPAiHPA051840.
HPA062239.

Interactioni

Protein-protein interaction databases

BioGridi120850. 1 interaction.
IntActiQ8WU58. 4 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ8WU58.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi148 – 22073Gln-richAdd
BLAST

Sequence similaritiesi

Belongs to the FAM222 family.Curated

Phylogenomic databases

eggNOGiNOG47137.
GeneTreeiENSGT00530000063811.
HOGENOMiHOG000111757.
HOVERGENiHBG058998.
InParanoidiQ8WU58.
OMAiHLQQMCG.
OrthoDBiEOG75F4CT.
PhylomeDBiQ8WU58.
TreeFamiTF331508.

Family and domain databases

InterProiIPR029340. FAM222.
[Graphical view]
PANTHERiPTHR16070. PTHR16070. 1 hit.
PfamiPF15258. FAM222A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WU58-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLACLPGPGD LSFQLLSHTQ MNTGLQKWDT TQKMRTAHYP TPAELDAYAK
60 70 80 90 100
KVANNPLTIK IFPNSVKVPQ RKHVRRTVNG LDTSAQRYSP YPTQAATKAG
110 120 130 140 150
LLAIVKVPAK SILKDFDGTR ARLLPEAIMN PPVAPYATVA PSTLAHPQAQ
160 170 180 190 200
ALARQQALQH AQTLAHAPPQ TLQHPQGIPP PQALSHPQSL QQPQGLGHPQ
210 220 230 240 250
PMAQTQGLVH PQALAHQGLQ HPHNPLLHGG RKMPDSDAPP NVTVSTSTIP
260 270 280 290 300
LSMAATLQHS QPPDLSSIVH QINQFCQTRA GISTTSVCEG QIANPSPISR
310 320 330 340 350
SLLINASTRV STHSVPTPMP SCVVNPMEHT HAATAALPAA GPVNLPTGIS
360 370 380 390 400
RVPTGYPSDL KPVTWNQHQL AHLQQMCSEA SGTPAPGLTG KHAAGRELAG
410 420 430 440 450
PGFVGKAPAY PQELCLAQSF HLKPPLEKPT PSPPVNGMAA PLAYPNGHYF
460 470 480 490 500
QPLWNNILPT PNSDSSGSQD LAMPFHGGQP TGAPLDCAAA PGAHYRAGTG
510 520 530 540 550
GGPVASQNSL MQTVDYLSGD FQQACFREQS LAMLSKAHRA PGNRAPDPTE
560
SRSLHIQHPG YR
Length:562
Mass (Da):59,652
Last modified:March 1, 2002 - v1
Checksum:i5DCE56EBA36523C3
GO

Sequence cautioni

The sequence BAA90974.1 differs from that shown. Reason: Frameshift at position 433. Curated
The sequence BAB15306.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti15 – 151L → P in BAA91757 (PubMed:14702039).Curated
Sequence conflicti261 – 2611Q → R in BAA91757 (PubMed:14702039).Curated
Sequence conflicti557 – 5571Q → L in BAA91757 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti471 – 4711L → S.
Corresponds to variant rs2043031 [ dbSNP | Ensembl ].
VAR_050900
Natural varianti542 – 5421G → S.
Corresponds to variant rs36029715 [ dbSNP | Ensembl ].
VAR_050901

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000147 mRNA. Translation: BAA90974.1. Frameshift.
AK001562 mRNA. Translation: BAA91757.1.
AK025980 mRNA. Translation: BAB15306.1. Different initiation.
AC010761 Genomic DNA. No translation available.
AC024267 Genomic DNA. No translation available.
BC021228 mRNA. Translation: AAH21228.1.
CCDSiCCDS45637.1.
RefSeqiNP_001070966.1. NM_001077498.2.
NP_001275560.1. NM_001288631.1.
NP_001275561.1. NM_001288632.1.
NP_001275562.1. NM_001288633.1.
NP_001275563.1. NM_001288634.1.
NP_001275564.1. NM_001288635.1.
NP_001275565.1. NM_001288636.1.
NP_001275566.1. NM_001288637.1.
NP_001275567.1. NM_001288638.1.
NP_001275568.1. NM_001288639.1.
NP_001275569.1. NM_001288640.1.
NP_060652.2. NM_018182.3.
UniGeneiHs.564533.

Genome annotation databases

EnsembliENST00000452648; ENSP00000413645; ENSG00000173065.
ENST00000581407; ENSP00000462419; ENSG00000173065.
GeneIDi55731.
KEGGihsa:55731.
UCSCiuc002hct.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000147 mRNA. Translation: BAA90974.1. Frameshift.
AK001562 mRNA. Translation: BAA91757.1.
AK025980 mRNA. Translation: BAB15306.1. Different initiation.
AC010761 Genomic DNA. No translation available.
AC024267 Genomic DNA. No translation available.
BC021228 mRNA. Translation: AAH21228.1.
CCDSiCCDS45637.1.
RefSeqiNP_001070966.1. NM_001077498.2.
NP_001275560.1. NM_001288631.1.
NP_001275561.1. NM_001288632.1.
NP_001275562.1. NM_001288633.1.
NP_001275563.1. NM_001288634.1.
NP_001275564.1. NM_001288635.1.
NP_001275565.1. NM_001288636.1.
NP_001275566.1. NM_001288637.1.
NP_001275567.1. NM_001288638.1.
NP_001275568.1. NM_001288639.1.
NP_001275569.1. NM_001288640.1.
NP_060652.2. NM_018182.3.
UniGeneiHs.564533.

3D structure databases

ProteinModelPortaliQ8WU58.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120850. 1 interaction.
IntActiQ8WU58. 4 interactions.

PTM databases

PhosphoSiteiQ8WU58.

Polymorphism and mutation databases

DMDMi74730670.

Proteomic databases

PaxDbiQ8WU58.
PRIDEiQ8WU58.

Protocols and materials databases

DNASUi55731.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000452648; ENSP00000413645; ENSG00000173065.
ENST00000581407; ENSP00000462419; ENSG00000173065.
GeneIDi55731.
KEGGihsa:55731.
UCSCiuc002hct.1. human.

Organism-specific databases

CTDi55731.
GeneCardsiGC17M027145.
H-InvDBHIX0013663.
HGNCiHGNC:25563. FAM222B.
HPAiHPA051840.
HPA062239.
neXtProtiNX_Q8WU58.
PharmGKBiPA142672246.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG47137.
GeneTreeiENSGT00530000063811.
HOGENOMiHOG000111757.
HOVERGENiHBG058998.
InParanoidiQ8WU58.
OMAiHLQQMCG.
OrthoDBiEOG75F4CT.
PhylomeDBiQ8WU58.
TreeFamiTF331508.

Enzyme and pathway databases

SignaLinkiQ8WU58.

Miscellaneous databases

ChiTaRSiFAM222B. human.
GenomeRNAii55731.
NextBioi60652.
PROiQ8WU58.

Gene expression databases

BgeeiQ8WU58.
CleanExiHS_C17orf63.
ExpressionAtlasiQ8WU58. baseline and differential.
GenevestigatoriQ8WU58.

Family and domain databases

InterProiIPR029340. FAM222.
[Graphical view]
PANTHERiPTHR16070. PTHR16070. 1 hit.
PfamiPF15258. FAM222A. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon, Kidney epithelium and Teratocarcinoma.
  2. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiF222B_HUMAN
AccessioniPrimary (citable) accession number: Q8WU58
Secondary accession number(s): Q9H6F3, Q9NVJ4, Q9NXN6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: March 1, 2002
Last modified: March 4, 2015
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.