Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8WU58

- F222B_HUMAN

UniProt

Q8WU58 - F222B_HUMAN

Protein

Protein FAM222B

Gene

FAM222B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Enzyme and pathway databases

    SignaLinkiQ8WU58.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein FAM222B
    Gene namesi
    Name:FAM222B
    Synonyms:C17orf63
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:25563. FAM222B.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142672246.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 562562Protein FAM222BPRO_0000274245Add
    BLAST

    Proteomic databases

    PaxDbiQ8WU58.
    PRIDEiQ8WU58.

    PTM databases

    PhosphoSiteiQ8WU58.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8WU58.
    BgeeiQ8WU58.
    CleanExiHS_C17orf63.
    GenevestigatoriQ8WU58.

    Organism-specific databases

    HPAiHPA051840.

    Interactioni

    Protein-protein interaction databases

    BioGridi120850. 2 interactions.
    IntActiQ8WU58. 4 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8WU58.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi148 – 22073Gln-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the FAM222 family.Curated

    Phylogenomic databases

    eggNOGiNOG47137.
    HOGENOMiHOG000111757.
    HOVERGENiHBG058998.
    InParanoidiQ8WU58.
    OMAiHLQQMCG.
    OrthoDBiEOG75F4CT.
    PhylomeDBiQ8WU58.
    TreeFamiTF331508.

    Family and domain databases

    InterProiIPR029340. FAM222.
    [Graphical view]
    PANTHERiPTHR16070. PTHR16070. 1 hit.
    PfamiPF15258. FAM222A. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8WU58-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLACLPGPGD LSFQLLSHTQ MNTGLQKWDT TQKMRTAHYP TPAELDAYAK    50
    KVANNPLTIK IFPNSVKVPQ RKHVRRTVNG LDTSAQRYSP YPTQAATKAG 100
    LLAIVKVPAK SILKDFDGTR ARLLPEAIMN PPVAPYATVA PSTLAHPQAQ 150
    ALARQQALQH AQTLAHAPPQ TLQHPQGIPP PQALSHPQSL QQPQGLGHPQ 200
    PMAQTQGLVH PQALAHQGLQ HPHNPLLHGG RKMPDSDAPP NVTVSTSTIP 250
    LSMAATLQHS QPPDLSSIVH QINQFCQTRA GISTTSVCEG QIANPSPISR 300
    SLLINASTRV STHSVPTPMP SCVVNPMEHT HAATAALPAA GPVNLPTGIS 350
    RVPTGYPSDL KPVTWNQHQL AHLQQMCSEA SGTPAPGLTG KHAAGRELAG 400
    PGFVGKAPAY PQELCLAQSF HLKPPLEKPT PSPPVNGMAA PLAYPNGHYF 450
    QPLWNNILPT PNSDSSGSQD LAMPFHGGQP TGAPLDCAAA PGAHYRAGTG 500
    GGPVASQNSL MQTVDYLSGD FQQACFREQS LAMLSKAHRA PGNRAPDPTE 550
    SRSLHIQHPG YR 562
    Length:562
    Mass (Da):59,652
    Last modified:March 1, 2002 - v1
    Checksum:i5DCE56EBA36523C3
    GO

    Sequence cautioni

    The sequence BAA90974.1 differs from that shown. Reason: Frameshift at position 433.
    The sequence BAB15306.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti15 – 151L → P in BAA91757. (PubMed:14702039)Curated
    Sequence conflicti261 – 2611Q → R in BAA91757. (PubMed:14702039)Curated
    Sequence conflicti557 – 5571Q → L in BAA91757. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti471 – 4711L → S.
    Corresponds to variant rs2043031 [ dbSNP | Ensembl ].
    VAR_050900
    Natural varianti542 – 5421G → S.
    Corresponds to variant rs36029715 [ dbSNP | Ensembl ].
    VAR_050901

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK000147 mRNA. Translation: BAA90974.1. Frameshift.
    AK001562 mRNA. Translation: BAA91757.1.
    AK025980 mRNA. Translation: BAB15306.1. Different initiation.
    AC010761 Genomic DNA. No translation available.
    AC024267 Genomic DNA. No translation available.
    BC021228 mRNA. Translation: AAH21228.1.
    CCDSiCCDS45637.1.
    RefSeqiNP_001070966.1. NM_001077498.2.
    NP_001275560.1. NM_001288631.1.
    NP_001275561.1. NM_001288632.1.
    NP_001275562.1. NM_001288633.1.
    NP_001275563.1. NM_001288634.1.
    NP_001275564.1. NM_001288635.1.
    NP_001275565.1. NM_001288636.1.
    NP_001275566.1. NM_001288637.1.
    NP_001275567.1. NM_001288638.1.
    NP_001275568.1. NM_001288639.1.
    NP_001275569.1. NM_001288640.1.
    NP_060652.2. NM_018182.3.
    UniGeneiHs.564533.

    Genome annotation databases

    EnsembliENST00000341217; ENSP00000343115; ENSG00000173065.
    ENST00000452648; ENSP00000413645; ENSG00000173065.
    ENST00000581407; ENSP00000462419; ENSG00000173065.
    GeneIDi55731.
    KEGGihsa:55731.
    UCSCiuc002hct.1. human.

    Polymorphism databases

    DMDMi74730670.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK000147 mRNA. Translation: BAA90974.1 . Frameshift.
    AK001562 mRNA. Translation: BAA91757.1 .
    AK025980 mRNA. Translation: BAB15306.1 . Different initiation.
    AC010761 Genomic DNA. No translation available.
    AC024267 Genomic DNA. No translation available.
    BC021228 mRNA. Translation: AAH21228.1 .
    CCDSi CCDS45637.1.
    RefSeqi NP_001070966.1. NM_001077498.2.
    NP_001275560.1. NM_001288631.1.
    NP_001275561.1. NM_001288632.1.
    NP_001275562.1. NM_001288633.1.
    NP_001275563.1. NM_001288634.1.
    NP_001275564.1. NM_001288635.1.
    NP_001275565.1. NM_001288636.1.
    NP_001275566.1. NM_001288637.1.
    NP_001275567.1. NM_001288638.1.
    NP_001275568.1. NM_001288639.1.
    NP_001275569.1. NM_001288640.1.
    NP_060652.2. NM_018182.3.
    UniGenei Hs.564533.

    3D structure databases

    ProteinModelPortali Q8WU58.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120850. 2 interactions.
    IntActi Q8WU58. 4 interactions.

    PTM databases

    PhosphoSitei Q8WU58.

    Polymorphism databases

    DMDMi 74730670.

    Proteomic databases

    PaxDbi Q8WU58.
    PRIDEi Q8WU58.

    Protocols and materials databases

    DNASUi 55731.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000341217 ; ENSP00000343115 ; ENSG00000173065 .
    ENST00000452648 ; ENSP00000413645 ; ENSG00000173065 .
    ENST00000581407 ; ENSP00000462419 ; ENSG00000173065 .
    GeneIDi 55731.
    KEGGi hsa:55731.
    UCSCi uc002hct.1. human.

    Organism-specific databases

    CTDi 55731.
    GeneCardsi GC17M027086.
    H-InvDB HIX0013663.
    HGNCi HGNC:25563. FAM222B.
    HPAi HPA051840.
    neXtProti NX_Q8WU58.
    PharmGKBi PA142672246.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG47137.
    HOGENOMi HOG000111757.
    HOVERGENi HBG058998.
    InParanoidi Q8WU58.
    OMAi HLQQMCG.
    OrthoDBi EOG75F4CT.
    PhylomeDBi Q8WU58.
    TreeFami TF331508.

    Enzyme and pathway databases

    SignaLinki Q8WU58.

    Miscellaneous databases

    ChiTaRSi FAM222B. human.
    GenomeRNAii 55731.
    NextBioi 60652.
    PROi Q8WU58.

    Gene expression databases

    ArrayExpressi Q8WU58.
    Bgeei Q8WU58.
    CleanExi HS_C17orf63.
    Genevestigatori Q8WU58.

    Family and domain databases

    InterProi IPR029340. FAM222.
    [Graphical view ]
    PANTHERi PTHR16070. PTHR16070. 1 hit.
    Pfami PF15258. FAM222A. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Colon, Kidney epithelium and Teratocarcinoma.
    2. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.

    Entry informationi

    Entry nameiF222B_HUMAN
    AccessioniPrimary (citable) accession number: Q8WU58
    Secondary accession number(s): Q9H6F3, Q9NVJ4, Q9NXN6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 6, 2007
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3