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Q8WU58 (F222B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein FAM222B
Gene names
Name:FAM222B
Synonyms:C17orf63
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length562 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the FAM222 family.

Sequence caution

The sequence BAA90974.1 differs from that shown. Reason: Frameshift at position 433.

The sequence BAB15306.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 562562Protein FAM222B
PRO_0000274245

Regions

Compositional bias148 – 22073Gln-rich

Natural variations

Natural variant4711L → S.
Corresponds to variant rs2043031 [ dbSNP | Ensembl ].
VAR_050900
Natural variant5421G → S.
Corresponds to variant rs36029715 [ dbSNP | Ensembl ].
VAR_050901

Experimental info

Sequence conflict151L → P in BAA91757. Ref.1
Sequence conflict2611Q → R in BAA91757. Ref.1
Sequence conflict5571Q → L in BAA91757. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q8WU58 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 5DCE56EBA36523C3

FASTA56259,652
        10         20         30         40         50         60 
MLACLPGPGD LSFQLLSHTQ MNTGLQKWDT TQKMRTAHYP TPAELDAYAK KVANNPLTIK 

        70         80         90        100        110        120 
IFPNSVKVPQ RKHVRRTVNG LDTSAQRYSP YPTQAATKAG LLAIVKVPAK SILKDFDGTR 

       130        140        150        160        170        180 
ARLLPEAIMN PPVAPYATVA PSTLAHPQAQ ALARQQALQH AQTLAHAPPQ TLQHPQGIPP 

       190        200        210        220        230        240 
PQALSHPQSL QQPQGLGHPQ PMAQTQGLVH PQALAHQGLQ HPHNPLLHGG RKMPDSDAPP 

       250        260        270        280        290        300 
NVTVSTSTIP LSMAATLQHS QPPDLSSIVH QINQFCQTRA GISTTSVCEG QIANPSPISR 

       310        320        330        340        350        360 
SLLINASTRV STHSVPTPMP SCVVNPMEHT HAATAALPAA GPVNLPTGIS RVPTGYPSDL 

       370        380        390        400        410        420 
KPVTWNQHQL AHLQQMCSEA SGTPAPGLTG KHAAGRELAG PGFVGKAPAY PQELCLAQSF 

       430        440        450        460        470        480 
HLKPPLEKPT PSPPVNGMAA PLAYPNGHYF QPLWNNILPT PNSDSSGSQD LAMPFHGGQP 

       490        500        510        520        530        540 
TGAPLDCAAA PGAHYRAGTG GGPVASQNSL MQTVDYLSGD FQQACFREQS LAMLSKAHRA 

       550        560 
PGNRAPDPTE SRSLHIQHPG YR 

« Hide

References

[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Colon, Kidney epithelium and Teratocarcinoma.
[2]"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. expand/collapse author list , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK000147 mRNA. Translation: BAA90974.1. Frameshift.
AK001562 mRNA. Translation: BAA91757.1.
AK025980 mRNA. Translation: BAB15306.1. Different initiation.
AC010761 Genomic DNA. No translation available.
AC024267 Genomic DNA. No translation available.
BC021228 mRNA. Translation: AAH21228.1.
RefSeqNP_001070966.1. NM_001077498.2.
NP_001275560.1. NM_001288631.1.
NP_001275561.1. NM_001288632.1.
NP_001275562.1. NM_001288633.1.
NP_001275563.1. NM_001288634.1.
NP_001275564.1. NM_001288635.1.
NP_001275565.1. NM_001288636.1.
NP_001275566.1. NM_001288637.1.
NP_001275567.1. NM_001288638.1.
NP_001275568.1. NM_001288639.1.
NP_001275569.1. NM_001288640.1.
NP_060652.2. NM_018182.3.
UniGeneHs.564533.

3D structure databases

ProteinModelPortalQ8WU58.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120850. 2 interactions.
IntActQ8WU58. 4 interactions.

PTM databases

PhosphoSiteQ8WU58.

Polymorphism databases

DMDM74730670.

Proteomic databases

PaxDbQ8WU58.
PRIDEQ8WU58.

Protocols and materials databases

DNASU55731.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000341217; ENSP00000343115; ENSG00000173065.
ENST00000452648; ENSP00000413645; ENSG00000173065.
ENST00000581407; ENSP00000462419; ENSG00000173065.
GeneID55731.
KEGGhsa:55731.
UCSCuc002hct.1. human.

Organism-specific databases

CTD55731.
GeneCardsGC17M027086.
H-InvDBHIX0013663.
HGNCHGNC:25563. FAM222B.
HPAHPA051840.
neXtProtNX_Q8WU58.
PharmGKBPA142672246.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG47137.
HOGENOMHOG000111757.
HOVERGENHBG058998.
InParanoidQ8WU58.
OMAHLQQMCG.
OrthoDBEOG75F4CT.
PhylomeDBQ8WU58.
TreeFamTF331508.

Enzyme and pathway databases

SignaLinkQ8WU58.

Gene expression databases

ArrayExpressQ8WU58.
BgeeQ8WU58.
CleanExHS_C17orf63.
GenevestigatorQ8WU58.

Family and domain databases

ProtoNetSearch...

Other

ChiTaRSFAM222B. human.
GenomeRNAi55731.
NextBio60652.
PROQ8WU58.

Entry information

Entry nameF222B_HUMAN
AccessionPrimary (citable) accession number: Q8WU58
Secondary accession number(s): Q9H6F3, Q9NVJ4, Q9NXN6
Entry history
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: March 1, 2002
Last modified: April 16, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM