Q8WU58 (F222B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein FAM222B

Gene names

Name:	FAM222B
Synonyms:	C17orf63

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	562 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities	Belongs to the FAM222 family.
Sequence caution	The sequence BAA90974.1 differs from that shown. Reason: Frameshift at position 433. The sequence BAB15306.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 562	562	Protein FAM222B		PRO_0000274245
Regions
	Compositional bias	148 – 220	73	Gln-rich
Natural variations
	Natural variant	471	1	L → S. Corresponds to variant rs2043031 [ dbSNP | Ensembl ].		VAR_050900
	Natural variant	542	1	G → S. Corresponds to variant rs36029715 [ dbSNP | Ensembl ].		VAR_050901
Experimental info
	Sequence conflict	15	1	L → P in BAA91757. Ref.1
	Sequence conflict	261	1	Q → R in BAA91757. Ref.1
	Sequence conflict	557	1	Q → L in BAA91757. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q8WU58 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 5DCE56EBA36523C3	FASTA	562	59,652
	10 20 30 40 50 60 MLACLPGPGD LSFQLLSHTQ MNTGLQKWDT TQKMRTAHYP TPAELDAYAK KVANNPLTIK 70 80 90 100 110 120 IFPNSVKVPQ RKHVRRTVNG LDTSAQRYSP YPTQAATKAG LLAIVKVPAK SILKDFDGTR 130 140 150 160 170 180 ARLLPEAIMN PPVAPYATVA PSTLAHPQAQ ALARQQALQH AQTLAHAPPQ TLQHPQGIPP 190 200 210 220 230 240 PQALSHPQSL QQPQGLGHPQ PMAQTQGLVH PQALAHQGLQ HPHNPLLHGG RKMPDSDAPP 250 260 270 280 290 300 NVTVSTSTIP LSMAATLQHS QPPDLSSIVH QINQFCQTRA GISTTSVCEG QIANPSPISR 310 320 330 340 350 360 SLLINASTRV STHSVPTPMP SCVVNPMEHT HAATAALPAA GPVNLPTGIS RVPTGYPSDL 370 380 390 400 410 420 KPVTWNQHQL AHLQQMCSEA SGTPAPGLTG KHAAGRELAG PGFVGKAPAY PQELCLAQSF 430 440 450 460 470 480 HLKPPLEKPT PSPPVNGMAA PLAYPNGHYF QPLWNNILPT PNSDSSGSQD LAMPFHGGQP 490 500 510 520 530 540 TGAPLDCAAA PGAHYRAGTG GGPVASQNSL MQTVDYLSGD FQQACFREQS LAMLSKAHRA 550 560 PGNRAPDPTE SRSLHIQHPG YR

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon, Kidney epithelium and Teratocarcinoma.
[2]	"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C. Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK000147 mRNA. Translation: BAA90974.1. Frameshift. AK001562 mRNA. Translation: BAA91757.1. AK025980 mRNA. Translation: BAB15306.1. Different initiation. AC010761 Genomic DNA. No translation available. AC024267 Genomic DNA. No translation available. BC021228 mRNA. Translation: AAH21228.1.
IPI	IPI00291010.
RefSeq	NP_001070966.1. NM_001077498.1. NP_060652.2. NM_018182.2.
UniGene	Hs.564533.
3D structure databases
ProteinModelPortal	Q8WU58.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8WU58. 3 interactions.
PTM databases
PhosphoSite	Q8WU58.
Polymorphism databases
DMDM	74730670.
Proteomic databases
PaxDb	Q8WU58.
PRIDE	Q8WU58.
Protocols and materials databases
DNASU	55731.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000341217; ENSP00000343115; ENSG00000173065. ENST00000452648; ENSP00000413645; ENSG00000173065. ENST00000581407; ENSP00000462419; ENSG00000173065.
GeneID	55731.
KEGG	hsa:55731.
UCSC	uc002hct.1. human.
Organism-specific databases
CTD	55731.
GeneCards	GC17M027086.
H-InvDB	HIX0013663.
HGNC	HGNC:25563. FAM222B.
HPA	HPA051840.
neXtProt	NX_Q8WU58.
PharmGKB	PA142672246.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG47137.
HOGENOM	HOG000111757.
HOVERGEN	HBG058998.
InParanoid	Q8WU58.
OMA	HLQQMCG.
OrthoDB	EOG45QHD5.
Gene expression databases
ArrayExpress	Q8WU58.
Bgee	Q8WU58.
CleanEx	HS_C17orf63.
Genevestigator	Q8WU58.
Family and domain databases
ProtoNet	Search...
Other
ChiTaRS	FAM222B. human.
GenomeRNAi	55731.
NextBio	60652.

Entry information

Entry name

F222B_HUMAN

Accession

Primary (citable) accession number: Q8WU58
Secondary accession number(s): Q9H6F3, Q9NVJ4, Q9NXN6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 6, 2007
Last sequence update:	March 1, 2002
Last modified:	March 6, 2013
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.