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Protein

Protein FAM222B

Gene

FAM222B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

SignaLinkiQ8WU58

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM222B
Gene namesi
Name:FAM222B
Synonyms:C17orf63
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000173065.13
HGNCiHGNC:25563 FAM222B
neXtProtiNX_Q8WU58

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000173065
PharmGKBiPA142672246

Polymorphism and mutation databases

DMDMi74730670

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002742451 – 562Protein FAM222BAdd BLAST562

Proteomic databases

EPDiQ8WU58
PaxDbiQ8WU58
PeptideAtlasiQ8WU58
PRIDEiQ8WU58
ProteomicsDBi74633

PTM databases

iPTMnetiQ8WU58
PhosphoSitePlusiQ8WU58

Expressioni

Gene expression databases

BgeeiENSG00000173065
CleanExiHS_C17orf63
ExpressionAtlasiQ8WU58 baseline and differential
GenevisibleiQ8WU58 HS

Organism-specific databases

HPAiHPA051840
HPA062239

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PFDN5Q994714EBI-2807642,EBI-357275

Protein-protein interaction databases

BioGridi120850, 1 interactor
IntActiQ8WU58, 37 interactors

Structurei

3D structure databases

ProteinModelPortaliQ8WU58
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi148 – 220Gln-richAdd BLAST73

Sequence similaritiesi

Belongs to the FAM222 family.Curated

Phylogenomic databases

eggNOGiENOG410IEMV Eukaryota
ENOG410YNEB LUCA
GeneTreeiENSGT00530000063811
HOGENOMiHOG000111757
HOVERGENiHBG058998
InParanoidiQ8WU58
OMAiRAPTGYP
OrthoDBiEOG091G0401
PhylomeDBiQ8WU58
TreeFamiTF331508

Family and domain databases

InterProiView protein in InterPro
IPR029340 FAM222
PANTHERiPTHR16070 PTHR16070, 1 hit
PfamiView protein in Pfam
PF15258 FAM222A, 1 hit

Sequencei

Sequence statusi: Complete.

Q8WU58-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLACLPGPGD LSFQLLSHTQ MNTGLQKWDT TQKMRTAHYP TPAELDAYAK
60 70 80 90 100
KVANNPLTIK IFPNSVKVPQ RKHVRRTVNG LDTSAQRYSP YPTQAATKAG
110 120 130 140 150
LLAIVKVPAK SILKDFDGTR ARLLPEAIMN PPVAPYATVA PSTLAHPQAQ
160 170 180 190 200
ALARQQALQH AQTLAHAPPQ TLQHPQGIPP PQALSHPQSL QQPQGLGHPQ
210 220 230 240 250
PMAQTQGLVH PQALAHQGLQ HPHNPLLHGG RKMPDSDAPP NVTVSTSTIP
260 270 280 290 300
LSMAATLQHS QPPDLSSIVH QINQFCQTRA GISTTSVCEG QIANPSPISR
310 320 330 340 350
SLLINASTRV STHSVPTPMP SCVVNPMEHT HAATAALPAA GPVNLPTGIS
360 370 380 390 400
RVPTGYPSDL KPVTWNQHQL AHLQQMCSEA SGTPAPGLTG KHAAGRELAG
410 420 430 440 450
PGFVGKAPAY PQELCLAQSF HLKPPLEKPT PSPPVNGMAA PLAYPNGHYF
460 470 480 490 500
QPLWNNILPT PNSDSSGSQD LAMPFHGGQP TGAPLDCAAA PGAHYRAGTG
510 520 530 540 550
GGPVASQNSL MQTVDYLSGD FQQACFREQS LAMLSKAHRA PGNRAPDPTE
560
SRSLHIQHPG YR
Length:562
Mass (Da):59,652
Last modified:March 1, 2002 - v1
Checksum:i5DCE56EBA36523C3
GO

Sequence cautioni

The sequence BAA90974 differs from that shown. Reason: Frameshift at position 433.Curated
The sequence BAB15306 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti15L → P in BAA91757 (PubMed:14702039).Curated1
Sequence conflicti261Q → R in BAA91757 (PubMed:14702039).Curated1
Sequence conflicti557Q → L in BAA91757 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050900471L → S. Corresponds to variant dbSNP:rs2043031Ensembl.1
Natural variantiVAR_050901542G → S. Corresponds to variant dbSNP:rs36029715Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000147 mRNA Translation: BAA90974.1 Frameshift.
AK001562 mRNA Translation: BAA91757.1
AK025980 mRNA Translation: BAB15306.1 Different initiation.
AC010761 Genomic DNA No translation available.
AC024267 Genomic DNA No translation available.
BC021228 mRNA Translation: AAH21228.1
CCDSiCCDS45637.1
RefSeqiNP_001070966.1, NM_001077498.2
NP_001275560.1, NM_001288631.1
NP_001275561.1, NM_001288632.1
NP_001275562.1, NM_001288633.1
NP_001275563.1, NM_001288634.1
NP_001275564.1, NM_001288635.1
NP_001275565.1, NM_001288636.1
NP_001275566.1, NM_001288637.1
NP_001275567.1, NM_001288638.1
NP_001275568.1, NM_001288639.1
NP_001275569.1, NM_001288640.1
NP_060652.2, NM_018182.3
XP_016880320.1, XM_017024831.1
XP_016880321.1, XM_017024832.1
XP_016880322.1, XM_017024833.1
XP_016880323.1, XM_017024834.1
UniGeneiHs.564533

Genome annotation databases

EnsembliENST00000452648; ENSP00000413645; ENSG00000173065
ENST00000581407; ENSP00000462419; ENSG00000173065
GeneIDi55731
KEGGihsa:55731
UCSCiuc002hct.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiF222B_HUMAN
AccessioniPrimary (citable) accession number: Q8WU58
Secondary accession number(s): Q9H6F3, Q9NVJ4, Q9NXN6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: March 1, 2002
Last modified: June 20, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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