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Q8WU58

- F222B_HUMAN

UniProt

Q8WU58 - F222B_HUMAN

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Protein

Protein FAM222B

Gene

FAM222B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

SignaLinkiQ8WU58.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM222B
Gene namesi
Name:FAM222B
Synonyms:C17orf63
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:25563. FAM222B.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672246.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 562562Protein FAM222BPRO_0000274245Add
BLAST

Proteomic databases

PaxDbiQ8WU58.
PRIDEiQ8WU58.

PTM databases

PhosphoSiteiQ8WU58.

Expressioni

Gene expression databases

BgeeiQ8WU58.
CleanExiHS_C17orf63.
ExpressionAtlasiQ8WU58. baseline and differential.
GenevestigatoriQ8WU58.

Organism-specific databases

HPAiHPA051840.

Interactioni

Protein-protein interaction databases

BioGridi120850. 2 interactions.
IntActiQ8WU58. 4 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ8WU58.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi148 – 22073Gln-richAdd
BLAST

Sequence similaritiesi

Belongs to the FAM222 family.Curated

Phylogenomic databases

eggNOGiNOG47137.
GeneTreeiENSGT00530000063811.
HOGENOMiHOG000111757.
HOVERGENiHBG058998.
InParanoidiQ8WU58.
OMAiHLQQMCG.
OrthoDBiEOG75F4CT.
PhylomeDBiQ8WU58.
TreeFamiTF331508.

Family and domain databases

InterProiIPR029340. FAM222.
[Graphical view]
PANTHERiPTHR16070. PTHR16070. 1 hit.
PfamiPF15258. FAM222A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WU58-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLACLPGPGD LSFQLLSHTQ MNTGLQKWDT TQKMRTAHYP TPAELDAYAK
60 70 80 90 100
KVANNPLTIK IFPNSVKVPQ RKHVRRTVNG LDTSAQRYSP YPTQAATKAG
110 120 130 140 150
LLAIVKVPAK SILKDFDGTR ARLLPEAIMN PPVAPYATVA PSTLAHPQAQ
160 170 180 190 200
ALARQQALQH AQTLAHAPPQ TLQHPQGIPP PQALSHPQSL QQPQGLGHPQ
210 220 230 240 250
PMAQTQGLVH PQALAHQGLQ HPHNPLLHGG RKMPDSDAPP NVTVSTSTIP
260 270 280 290 300
LSMAATLQHS QPPDLSSIVH QINQFCQTRA GISTTSVCEG QIANPSPISR
310 320 330 340 350
SLLINASTRV STHSVPTPMP SCVVNPMEHT HAATAALPAA GPVNLPTGIS
360 370 380 390 400
RVPTGYPSDL KPVTWNQHQL AHLQQMCSEA SGTPAPGLTG KHAAGRELAG
410 420 430 440 450
PGFVGKAPAY PQELCLAQSF HLKPPLEKPT PSPPVNGMAA PLAYPNGHYF
460 470 480 490 500
QPLWNNILPT PNSDSSGSQD LAMPFHGGQP TGAPLDCAAA PGAHYRAGTG
510 520 530 540 550
GGPVASQNSL MQTVDYLSGD FQQACFREQS LAMLSKAHRA PGNRAPDPTE
560
SRSLHIQHPG YR
Length:562
Mass (Da):59,652
Last modified:March 1, 2002 - v1
Checksum:i5DCE56EBA36523C3
GO

Sequence cautioni

The sequence BAA90974.1 differs from that shown. Reason: Frameshift at position 433.
The sequence BAB15306.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti15 – 151L → P in BAA91757. (PubMed:14702039)Curated
Sequence conflicti261 – 2611Q → R in BAA91757. (PubMed:14702039)Curated
Sequence conflicti557 – 5571Q → L in BAA91757. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti471 – 4711L → S.
Corresponds to variant rs2043031 [ dbSNP | Ensembl ].
VAR_050900
Natural varianti542 – 5421G → S.
Corresponds to variant rs36029715 [ dbSNP | Ensembl ].
VAR_050901

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK000147 mRNA. Translation: BAA90974.1. Frameshift.
AK001562 mRNA. Translation: BAA91757.1.
AK025980 mRNA. Translation: BAB15306.1. Different initiation.
AC010761 Genomic DNA. No translation available.
AC024267 Genomic DNA. No translation available.
BC021228 mRNA. Translation: AAH21228.1.
CCDSiCCDS45637.1.
RefSeqiNP_001070966.1. NM_001077498.2.
NP_001275560.1. NM_001288631.1.
NP_001275561.1. NM_001288632.1.
NP_001275562.1. NM_001288633.1.
NP_001275563.1. NM_001288634.1.
NP_001275564.1. NM_001288635.1.
NP_001275565.1. NM_001288636.1.
NP_001275566.1. NM_001288637.1.
NP_001275567.1. NM_001288638.1.
NP_001275568.1. NM_001288639.1.
NP_001275569.1. NM_001288640.1.
NP_060652.2. NM_018182.3.
UniGeneiHs.564533.

Genome annotation databases

EnsembliENST00000452648; ENSP00000413645; ENSG00000173065.
ENST00000581407; ENSP00000462419; ENSG00000173065.
GeneIDi55731.
KEGGihsa:55731.
UCSCiuc002hct.1. human.

Polymorphism databases

DMDMi74730670.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK000147 mRNA. Translation: BAA90974.1 . Frameshift.
AK001562 mRNA. Translation: BAA91757.1 .
AK025980 mRNA. Translation: BAB15306.1 . Different initiation.
AC010761 Genomic DNA. No translation available.
AC024267 Genomic DNA. No translation available.
BC021228 mRNA. Translation: AAH21228.1 .
CCDSi CCDS45637.1.
RefSeqi NP_001070966.1. NM_001077498.2.
NP_001275560.1. NM_001288631.1.
NP_001275561.1. NM_001288632.1.
NP_001275562.1. NM_001288633.1.
NP_001275563.1. NM_001288634.1.
NP_001275564.1. NM_001288635.1.
NP_001275565.1. NM_001288636.1.
NP_001275566.1. NM_001288637.1.
NP_001275567.1. NM_001288638.1.
NP_001275568.1. NM_001288639.1.
NP_001275569.1. NM_001288640.1.
NP_060652.2. NM_018182.3.
UniGenei Hs.564533.

3D structure databases

ProteinModelPortali Q8WU58.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120850. 2 interactions.
IntActi Q8WU58. 4 interactions.

PTM databases

PhosphoSitei Q8WU58.

Polymorphism databases

DMDMi 74730670.

Proteomic databases

PaxDbi Q8WU58.
PRIDEi Q8WU58.

Protocols and materials databases

DNASUi 55731.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000452648 ; ENSP00000413645 ; ENSG00000173065 .
ENST00000581407 ; ENSP00000462419 ; ENSG00000173065 .
GeneIDi 55731.
KEGGi hsa:55731.
UCSCi uc002hct.1. human.

Organism-specific databases

CTDi 55731.
GeneCardsi GC17M027145.
H-InvDB HIX0013663.
HGNCi HGNC:25563. FAM222B.
HPAi HPA051840.
neXtProti NX_Q8WU58.
PharmGKBi PA142672246.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG47137.
GeneTreei ENSGT00530000063811.
HOGENOMi HOG000111757.
HOVERGENi HBG058998.
InParanoidi Q8WU58.
OMAi HLQQMCG.
OrthoDBi EOG75F4CT.
PhylomeDBi Q8WU58.
TreeFami TF331508.

Enzyme and pathway databases

SignaLinki Q8WU58.

Miscellaneous databases

ChiTaRSi FAM222B. human.
GenomeRNAii 55731.
NextBioi 60652.
PROi Q8WU58.

Gene expression databases

Bgeei Q8WU58.
CleanExi HS_C17orf63.
ExpressionAtlasi Q8WU58. baseline and differential.
Genevestigatori Q8WU58.

Family and domain databases

InterProi IPR029340. FAM222.
[Graphical view ]
PANTHERi PTHR16070. PTHR16070. 1 hit.
Pfami PF15258. FAM222A. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon, Kidney epithelium and Teratocarcinoma.
  2. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiF222B_HUMAN
AccessioniPrimary (citable) accession number: Q8WU58
Secondary accession number(s): Q9H6F3, Q9NVJ4, Q9NXN6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: March 1, 2002
Last modified: October 29, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3