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Q8WU39

- MZB1_HUMAN

UniProt

Q8WU39 - MZB1_HUMAN

Protein

Marginal zone B- and B1-cell-specific protein

Gene

MZB1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity By similarity. Isoform 2 may be involved in regulation of apoptosis. Helps to diversify peripheral B-cell functions by regulating Ca2+ stores, antibody secretion and integrin activation.By similarity
    Acts as a hormone-regulated adipokine/proinflammatory cytokine that is implicated in causing chronic inflammation, affecting cellular expansion and blunting insulin response in adipocytes. May have a role in the onset of insulin resistance.

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. integrin activation Source: UniProtKB
    3. negative regulation of glucose import in response to insulin stimulus Source: UniProtKB
    4. positive regulation of cell proliferation Source: UniProtKB
    5. positive regulation of immunoglobulin biosynthetic process Source: UniProtKB
    6. regulation of B cell proliferation Source: UniProtKB
    7. regulation of cell proliferation Source: UniProtKB

    Keywords - Biological processi

    Apoptosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Marginal zone B- and B1-cell-specific protein
    Alternative name(s):
    Mesenteric estrogen-dependent adipose 7
    Short name:
    MEDA-7
    Plasma cell-induced resident endoplasmic reticulum protein
    Short name:
    Plasma cell-induced resident ER protein
    Short name:
    pERp1
    Proapoptotic caspase adapter protein
    Gene namesi
    Name:MZB1
    Synonyms:MEDA7, PACAP
    ORF Names:HSPC190
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:30125. MZB1.

    Subcellular locationi

    Isoform 1 : Endoplasmic reticulum lumen PROSITE-ProRule annotation. Secreted
    Isoform 2 : Cytoplasm
    Note: Diffuse granular localization in the cytoplasm surrounding the nucleus.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. endoplasmic reticulum chaperone complex Source: UniProtKB
    3. endoplasmic reticulum lumen Source: UniProtKB
    4. extracellular region Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Endoplasmic reticulum, Secreted

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi50 – 501C → S: Does not affect activity. 1 Publication
    Mutagenesisi53 – 531C → S: No significant activity. 1 Publication
    Mutagenesisi95 – 951C → S: No significant activity. 1 Publication
    Mutagenesisi143 – 1431C → S: No significant activity. 1 Publication
    Mutagenesisi171 – 1711C → S: No significant activity. 1 Publication
    Mutagenesisi178 – 1781C → S: Does not affect activity. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 189167Marginal zone B- and B1-cell-specific proteinPRO_0000318740Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi50 ↔ 178By similarity
    Disulfide bondi53 ↔ 171By similarity
    Disulfide bondi95 ↔ 143By similarity

    Post-translational modificationi

    Forms an interchain disulfide bond with IgM monomers.By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    MaxQBiQ8WU39.
    PaxDbiQ8WU39.
    PRIDEiQ8WU39.

    PTM databases

    PhosphoSiteiQ8WU39.

    Expressioni

    Tissue specificityi

    Widely expressed with highest levels in adult brain, small intestine and lymphoid tissues such as thymus and spleen. Expression is frequently lower in intestinal-type gastric cancer. In obese patients, more abundant in omental than in subcutaneous fat.3 Publications

    Inductioni

    Down-regulated in primary B-cells early after ligand-stimulated activation. Up-regulated in bacterial lipopolysaccharides (LPS)-stimulated peritoneal macrophages.2 Publications

    Gene expression databases

    ArrayExpressiQ8WU39.
    BgeeiQ8WU39.
    GenevestigatoriQ8WU39.

    Organism-specific databases

    HPAiHPA043745.

    Interactioni

    Subunit structurei

    Part of the ER chaperone complex, a multi-protein complex in the endoplasmic reticulum containing a large number of molecular chaperones which associates with unassembled incompletely folded immunoglobulin heavy chains By similarity. Isoform 2 interacts with CASP2 and CASP9. Interacts with HSP90B1 and PDIA3 in a calcium-dependent manner By similarity.By similarity

    Protein-protein interaction databases

    BioGridi119399. 2 interactions.
    IntActiQ8WU39. 1 interaction.
    MINTiMINT-197959.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8WU39.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi186 – 1894Prevents secretion from ERPROSITE-ProRule annotation

    Sequence similaritiesi

    Belongs to the MZB1 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG74024.
    HOGENOMiHOG000068171.
    HOVERGENiHBG108230.
    InParanoidiQ8WU39.
    OMAiYQMWQHL.
    OrthoDBiEOG7D2FFZ.
    PhylomeDBiQ8WU39.

    Family and domain databases

    InterProiIPR021852. DUF3456.
    [Graphical view]
    PfamiPF11938. DUF3456. 1 hit.
    [Graphical view]
    PROSITEiPS00014. ER_TARGET. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8WU39-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRLSLPLLLL LLGAWAIPGG LGDRAPLTAT APQLDDEEMY SAHMPAHLRC    50
    DACRAVAYQM WQNLAKAETK LHTSNSGGRR ELSELVYTDV LDRSCSRNWQ 100
    DYGVREVDQV KRLTGPGLSE GPEPSISVMV TGGPWPTRLS RTCLHYLGEF 150
    GEDQIYEAHQ QGRGALEALL CGGPQGACSE KVSATREEL 189

    Note: Major.

    Length:189
    Mass (Da):20,694
    Last modified:March 1, 2002 - v1
    Checksum:iC71AED212D3393D3
    GO
    Isoform 2 (identifier: Q8WU39-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         60-189: MWQNLAKAET...EKVSATREEL → SLLVPDVAKS...PSETSHRPRT

    Show »
    Length:123
    Mass (Da):13,066
    Checksum:iC21A354CE08A95CB
    GO
    Isoform 3 (identifier: Q8WU39-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-92: Missing.
         93-101: RSCSRNWQD → MPAELWLTS

    Show »
    Length:97
    Mass (Da):10,488
    Checksum:i8BA52E533824C02C
    GO
    Isoform 4 (identifier: Q8WU39-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         60-75: MWQNLAKAETKLHTSN → RLCSYPPHLPLTEQQS
         76-189: Missing.

    Show »
    Length:75
    Mass (Da):8,227
    Checksum:iC43C7E99CF029FF8
    GO
    Isoform 5 (identifier: Q8WU39-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         60-62: MWQ → AHP
         63-189: Missing.

    Show »
    Length:62
    Mass (Da):6,681
    Checksum:i7E1F097F7B9F33F4
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 9292Missing in isoform 3. 1 PublicationVSP_031280Add
    BLAST
    Alternative sequencei60 – 189130MWQNL…TREEL → SLLVPDVAKSGKGRDQTSYL KLWGAAGAERVGLHGCPGPE LLPELAGLRSSRSGPSETSH RPRT in isoform 2. 1 PublicationVSP_031281Add
    BLAST
    Alternative sequencei60 – 7516MWQNL…LHTSN → RLCSYPPHLPLTEQQS in isoform 4. 1 PublicationVSP_038333Add
    BLAST
    Alternative sequencei60 – 623MWQ → AHP in isoform 5. 1 PublicationVSP_039073
    Alternative sequencei63 – 189127Missing in isoform 5. 1 PublicationVSP_039074Add
    BLAST
    Alternative sequencei76 – 189114Missing in isoform 4. 1 PublicationVSP_038334Add
    BLAST
    Alternative sequencei93 – 1019RSCSRNWQD → MPAELWLTS in isoform 3. 1 PublicationVSP_038332

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF338109 mRNA. Translation: AAK84085.1.
    AF151024 mRNA. Translation: AAF36110.1. Sequence problems.
    BP366737 mRNA. No translation available.
    GQ477350 mRNA. Translation: ACY74343.1.
    AK292706 mRNA. Translation: BAF85395.1.
    AL698690 mRNA. No translation available.
    AC135457 Genomic DNA. No translation available.
    BC009931 mRNA. Translation: AAH09931.2.
    BC021275 mRNA. Translation: AAH21275.1.
    CCDSiCCDS47273.1. [Q8WU39-1]
    RefSeqiNP_057543.2. NM_016459.3. [Q8WU39-1]
    UniGeneiHs.409563.

    Genome annotation databases

    EnsembliENST00000302125; ENSP00000303920; ENSG00000170476. [Q8WU39-1]
    ENST00000417694; ENSP00000415420; ENSG00000170476. [Q8WU39-4]
    ENST00000503481; ENSP00000423205; ENSG00000170476. [Q8WU39-2]
    GeneIDi51237.
    KEGGihsa:51237.
    UCSCiuc003lei.3. human. [Q8WU39-1]
    uc010jfd.3. human. [Q8WU39-3]

    Polymorphism databases

    DMDMi74730663.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF338109 mRNA. Translation: AAK84085.1 .
    AF151024 mRNA. Translation: AAF36110.1 . Sequence problems.
    BP366737 mRNA. No translation available.
    GQ477350 mRNA. Translation: ACY74343.1 .
    AK292706 mRNA. Translation: BAF85395.1 .
    AL698690 mRNA. No translation available.
    AC135457 Genomic DNA. No translation available.
    BC009931 mRNA. Translation: AAH09931.2 .
    BC021275 mRNA. Translation: AAH21275.1 .
    CCDSi CCDS47273.1. [Q8WU39-1 ]
    RefSeqi NP_057543.2. NM_016459.3. [Q8WU39-1 ]
    UniGenei Hs.409563.

    3D structure databases

    ProteinModelPortali Q8WU39.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119399. 2 interactions.
    IntActi Q8WU39. 1 interaction.
    MINTi MINT-197959.

    PTM databases

    PhosphoSitei Q8WU39.

    Polymorphism databases

    DMDMi 74730663.

    Proteomic databases

    MaxQBi Q8WU39.
    PaxDbi Q8WU39.
    PRIDEi Q8WU39.

    Protocols and materials databases

    DNASUi 51237.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000302125 ; ENSP00000303920 ; ENSG00000170476 . [Q8WU39-1 ]
    ENST00000417694 ; ENSP00000415420 ; ENSG00000170476 . [Q8WU39-4 ]
    ENST00000503481 ; ENSP00000423205 ; ENSG00000170476 . [Q8WU39-2 ]
    GeneIDi 51237.
    KEGGi hsa:51237.
    UCSCi uc003lei.3. human. [Q8WU39-1 ]
    uc010jfd.3. human. [Q8WU39-3 ]

    Organism-specific databases

    CTDi 51237.
    GeneCardsi GC05M138723.
    HGNCi HGNC:30125. MZB1.
    HPAi HPA043745.
    MIMi 609447. gene.
    neXtProti NX_Q8WU39.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG74024.
    HOGENOMi HOG000068171.
    HOVERGENi HBG108230.
    InParanoidi Q8WU39.
    OMAi YQMWQHL.
    OrthoDBi EOG7D2FFZ.
    PhylomeDBi Q8WU39.

    Miscellaneous databases

    ChiTaRSi MZB1. human.
    GenomeRNAii 51237.
    NextBioi 54355.
    PROi Q8WU39.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8WU39.
    Bgeei Q8WU39.
    Genevestigatori Q8WU39.

    Family and domain databases

    InterProi IPR021852. DUF3456.
    [Graphical view ]
    Pfami PF11938. DUF3456. 1 hit.
    [Graphical view ]
    PROSITEi PS00014. ER_TARGET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of a novel proapoptotic caspase-2- and caspase-9-binding protein."
      Bonfoco E., Li E., Kolbinger F., Cooper N.R.
      J. Biol. Chem. 276:29242-29250(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION, INTERACTION WITH CASP2 AND CASP9.
    2. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
      Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
      , Gu J., Chen S.-J., Chen Z.
      Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
      Tissue: Umbilical cord blood.
    3. "pERp1 is significantly up-regulated during plasma cell differentiation and contributes to the oxidative folding of immunoglobulin."
      Shimizu Y., Meunier L., Hendershot L.M.
      Proc. Natl. Acad. Sci. U.S.A. 106:17013-17018(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MUTAGENESIS OF CYS-50; CYS-53; CYS-95; CYS-143; CYS-171 AND CYS-178.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Thymus.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
    6. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
      Tissue: B-cell and Lymph.
    8. "MGC29506 gene, frequently down-regulated in intestinal-type gastric cancer, encodes secreted-type protein with conserved cysteine residues."
      Katoh M., Katoh M.
      Int. J. Oncol. 23:235-241(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "Novel hormone-regulated genes in visceral adipose tissue: cloning and identification of proinflammatory cytokine-like mouse and human MEDA-7: implications for obesity, insulin resistance and the metabolic syndrome."
      Zhang H., Chen X., Sairam M.R.
      Diabetologia 54:2368-2380(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, INDUCTION, FUNCTION.

    Entry informationi

    Entry nameiMZB1_HUMAN
    AccessioniPrimary (citable) accession number: Q8WU39
    Secondary accession number(s): D2IYS0
    , Q7Z6N2, Q96RL5, Q9P0T3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3