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Q8WU10

- PYRD1_HUMAN

UniProt

Q8WU10 - PYRD1_HUMAN

Protein

Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1

Gene

PYROXD1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Cofactori

    Binds 1 FAD per subunit.By similarity

    GO - Molecular functioni

    1. oxidoreductase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    FAD, Flavoprotein, NADP

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1 (EC:1.8.1.-)
    Gene namesi
    Name:PYROXD1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:26162. PYROXD1.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162400525.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 500500Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1PRO_0000327419Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ8WU10.
    PaxDbiQ8WU10.
    PRIDEiQ8WU10.

    PTM databases

    PhosphoSiteiQ8WU10.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8WU10.
    BgeeiQ8WU10.
    CleanExiHS_PYROXD1.
    GenevestigatoriQ8WU10.

    Organism-specific databases

    HPAiHPA038319.

    Interactioni

    Protein-protein interaction databases

    BioGridi122992. 8 interactions.
    IntActiQ8WU10. 1 interaction.
    MINTiMINT-1476776.
    STRINGi9606.ENSP00000240651.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8WU10.
    SMRiQ8WU10. Positions 10-47, 149-180, 302-463.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0446.
    HOGENOMiHOG000265662.
    HOVERGENiHBG108313.
    InParanoidiQ8WU10.
    OMAiCEVIWAI.
    OrthoDBiEOG71P29Z.
    PhylomeDBiQ8WU10.
    TreeFamiTF105963.

    Family and domain databases

    InterProiIPR013027. FAD_pyr_nucl-diS_OxRdtase.
    IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
    [Graphical view]
    PfamiPF07992. Pyr_redox_2. 1 hit.
    [Graphical view]
    PRINTSiPR00368. FADPNR.

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8WU10-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEAARPPPTA GKFVVVGGGI AGVTCAEQLA THFPSEDILL VTASPVIKAV    50
    TNFKQISKIL EEFDVEEQSS TMLGKRFPNI KVIESGVKQL KSEEHCIVTE 100
    DGNQHVYKKL CLCAGAKPKL ICEGNPYVLG IRDTDSAQEF QKQLTKAKRI 150
    MIIGNGGIAL ELVYEIEGCE VIWAIKDKAI GNTFFDAGAA EFLTSKLIAE 200
    KSEAKIAHKR TRYTTEGRKK EARSKSKADN VGSALGPDWH EGLNLKGTKE 250
    FSHKIHLETM CEVKKIYLQD EFRILKKKSF TFPRDHKSVT ADTEMWPVYV 300
    ELTNEKIYGC DFIVSATGVT PNVEPFLHGN SFDLGEDGGL KVDDHMHTSL 350
    PDIYAAGDIC TTSWQLSPVW QQMRLWTQAR QMGWYAAKCM AAASSGDSID 400
    MDFSFELFAH VTKFFNYKVV LLGKYNAQGL GSDHELMLRC TKGREYIKVV 450
    MQNGRMMGAV LIGETDLEET FENLILNQMN LSSYGEDLLD PNIDIEDYFD 500
    Length:500
    Mass (Da):55,793
    Last modified:March 1, 2002 - v1
    Checksum:i26F1AA7E09BA885B
    GO
    Isoform 2 (identifier: Q8WU10-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-71: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:429
    Mass (Da):48,338
    Checksum:i85297DE2F0154F82
    GO

    Sequence cautioni

    The sequence BAB15214.1 differs from that shown. Reason: Frameshift at position 445.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 7171Missing in isoform 2. 1 PublicationVSP_055828Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK025681 mRNA. Translation: BAB15214.1. Frameshift.
    AK125461 mRNA. Translation: BAG54200.1.
    AL832441 mRNA. Translation: CAH10632.1.
    AC006559 Genomic DNA. No translation available.
    CH471094 Genomic DNA. Translation: EAW96428.1.
    BC021662 mRNA. Translation: AAH21662.1.
    CCDSiCCDS31755.1.
    RefSeqiNP_079130.2. NM_024854.3.
    UniGeneiHs.709545.

    Genome annotation databases

    EnsembliENST00000240651; ENSP00000240651; ENSG00000121350. [Q8WU10-1]
    ENST00000538582; ENSP00000438505; ENSG00000121350. [Q8WU10-2]
    GeneIDi79912.
    KEGGihsa:79912.
    UCSCiuc001rew.3. human.

    Polymorphism databases

    DMDMi74760541.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK025681 mRNA. Translation: BAB15214.1 . Frameshift.
    AK125461 mRNA. Translation: BAG54200.1 .
    AL832441 mRNA. Translation: CAH10632.1 .
    AC006559 Genomic DNA. No translation available.
    CH471094 Genomic DNA. Translation: EAW96428.1 .
    BC021662 mRNA. Translation: AAH21662.1 .
    CCDSi CCDS31755.1.
    RefSeqi NP_079130.2. NM_024854.3.
    UniGenei Hs.709545.

    3D structure databases

    ProteinModelPortali Q8WU10.
    SMRi Q8WU10. Positions 10-47, 149-180, 302-463.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122992. 8 interactions.
    IntActi Q8WU10. 1 interaction.
    MINTi MINT-1476776.
    STRINGi 9606.ENSP00000240651.

    PTM databases

    PhosphoSitei Q8WU10.

    Polymorphism databases

    DMDMi 74760541.

    Proteomic databases

    MaxQBi Q8WU10.
    PaxDbi Q8WU10.
    PRIDEi Q8WU10.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000240651 ; ENSP00000240651 ; ENSG00000121350 . [Q8WU10-1 ]
    ENST00000538582 ; ENSP00000438505 ; ENSG00000121350 . [Q8WU10-2 ]
    GeneIDi 79912.
    KEGGi hsa:79912.
    UCSCi uc001rew.3. human.

    Organism-specific databases

    CTDi 79912.
    GeneCardsi GC12P021590.
    HGNCi HGNC:26162. PYROXD1.
    HPAi HPA038319.
    neXtProti NX_Q8WU10.
    PharmGKBi PA162400525.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0446.
    HOGENOMi HOG000265662.
    HOVERGENi HBG108313.
    InParanoidi Q8WU10.
    OMAi CEVIWAI.
    OrthoDBi EOG71P29Z.
    PhylomeDBi Q8WU10.
    TreeFami TF105963.

    Miscellaneous databases

    GenomeRNAii 79912.
    NextBioi 69782.
    PROi Q8WU10.

    Gene expression databases

    ArrayExpressi Q8WU10.
    Bgeei Q8WU10.
    CleanExi HS_PYROXD1.
    Genevestigatori Q8WU10.

    Family and domain databases

    InterProi IPR013027. FAD_pyr_nucl-diS_OxRdtase.
    IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
    [Graphical view ]
    Pfami PF07992. Pyr_redox_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00368. FADPNR.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain and Hepatoma.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Melanoma.
    3. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Kidney.
    6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiPYRD1_HUMAN
    AccessioniPrimary (citable) accession number: Q8WU10
    Secondary accession number(s): A6NKI6, B3KWN8, Q9H6P1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3