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Protein

Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1

Gene

PYROXD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Cofactori

FADBy similarityNote: Binds 1 FAD per subunit.By similarity

GO - Molecular functioni

  1. oxidoreductase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1 (EC:1.8.1.-)
Gene namesi
Name:PYROXD1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:26162. PYROXD1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162400525.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 500500Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1PRO_0000327419Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ8WU10.
PaxDbiQ8WU10.
PRIDEiQ8WU10.

PTM databases

PhosphoSiteiQ8WU10.

Expressioni

Gene expression databases

BgeeiQ8WU10.
CleanExiHS_PYROXD1.
ExpressionAtlasiQ8WU10. baseline and differential.
GenevestigatoriQ8WU10.

Organism-specific databases

HPAiHPA038319.

Interactioni

Protein-protein interaction databases

BioGridi122992. 8 interactions.
IntActiQ8WU10. 1 interaction.
MINTiMINT-1476776.
STRINGi9606.ENSP00000240651.

Structurei

3D structure databases

ProteinModelPortaliQ8WU10.
SMRiQ8WU10. Positions 10-47, 149-182, 302-463.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0446.
GeneTreeiENSGT00390000014894.
HOGENOMiHOG000265662.
HOVERGENiHBG108313.
InParanoidiQ8WU10.
OMAiCEVIWAI.
OrthoDBiEOG71P29Z.
PhylomeDBiQ8WU10.
TreeFamiTF105963.

Family and domain databases

InterProiIPR013027. FAD_pyr_nucl-diS_OxRdtase.
IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
[Graphical view]
PRINTSiPR00368. FADPNR.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8WU10-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEAARPPPTA GKFVVVGGGI AGVTCAEQLA THFPSEDILL VTASPVIKAV
60 70 80 90 100
TNFKQISKIL EEFDVEEQSS TMLGKRFPNI KVIESGVKQL KSEEHCIVTE
110 120 130 140 150
DGNQHVYKKL CLCAGAKPKL ICEGNPYVLG IRDTDSAQEF QKQLTKAKRI
160 170 180 190 200
MIIGNGGIAL ELVYEIEGCE VIWAIKDKAI GNTFFDAGAA EFLTSKLIAE
210 220 230 240 250
KSEAKIAHKR TRYTTEGRKK EARSKSKADN VGSALGPDWH EGLNLKGTKE
260 270 280 290 300
FSHKIHLETM CEVKKIYLQD EFRILKKKSF TFPRDHKSVT ADTEMWPVYV
310 320 330 340 350
ELTNEKIYGC DFIVSATGVT PNVEPFLHGN SFDLGEDGGL KVDDHMHTSL
360 370 380 390 400
PDIYAAGDIC TTSWQLSPVW QQMRLWTQAR QMGWYAAKCM AAASSGDSID
410 420 430 440 450
MDFSFELFAH VTKFFNYKVV LLGKYNAQGL GSDHELMLRC TKGREYIKVV
460 470 480 490 500
MQNGRMMGAV LIGETDLEET FENLILNQMN LSSYGEDLLD PNIDIEDYFD
Length:500
Mass (Da):55,793
Last modified:March 1, 2002 - v1
Checksum:i26F1AA7E09BA885B
GO
Isoform 2 (identifier: Q8WU10-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-71: Missing.

Note: No experimental confirmation available.

Show »
Length:429
Mass (Da):48,338
Checksum:i85297DE2F0154F82
GO

Sequence cautioni

The sequence BAB15214.1 differs from that shown. Reason: Frameshift at position 445. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 7171Missing in isoform 2. 1 PublicationVSP_055828Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025681 mRNA. Translation: BAB15214.1. Frameshift.
AK125461 mRNA. Translation: BAG54200.1.
AL832441 mRNA. Translation: CAH10632.1.
AC006559 Genomic DNA. No translation available.
CH471094 Genomic DNA. Translation: EAW96428.1.
BC021662 mRNA. Translation: AAH21662.1.
CCDSiCCDS31755.1. [Q8WU10-1]
RefSeqiNP_079130.2. NM_024854.3. [Q8WU10-1]
UniGeneiHs.709545.

Genome annotation databases

EnsembliENST00000240651; ENSP00000240651; ENSG00000121350. [Q8WU10-1]
ENST00000538582; ENSP00000438505; ENSG00000121350. [Q8WU10-2]
GeneIDi79912.
KEGGihsa:79912.
UCSCiuc001rew.3. human. [Q8WU10-1]

Polymorphism databases

DMDMi74760541.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK025681 mRNA. Translation: BAB15214.1. Frameshift.
AK125461 mRNA. Translation: BAG54200.1.
AL832441 mRNA. Translation: CAH10632.1.
AC006559 Genomic DNA. No translation available.
CH471094 Genomic DNA. Translation: EAW96428.1.
BC021662 mRNA. Translation: AAH21662.1.
CCDSiCCDS31755.1. [Q8WU10-1]
RefSeqiNP_079130.2. NM_024854.3. [Q8WU10-1]
UniGeneiHs.709545.

3D structure databases

ProteinModelPortaliQ8WU10.
SMRiQ8WU10. Positions 10-47, 149-182, 302-463.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122992. 8 interactions.
IntActiQ8WU10. 1 interaction.
MINTiMINT-1476776.
STRINGi9606.ENSP00000240651.

PTM databases

PhosphoSiteiQ8WU10.

Polymorphism databases

DMDMi74760541.

Proteomic databases

MaxQBiQ8WU10.
PaxDbiQ8WU10.
PRIDEiQ8WU10.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000240651; ENSP00000240651; ENSG00000121350. [Q8WU10-1]
ENST00000538582; ENSP00000438505; ENSG00000121350. [Q8WU10-2]
GeneIDi79912.
KEGGihsa:79912.
UCSCiuc001rew.3. human. [Q8WU10-1]

Organism-specific databases

CTDi79912.
GeneCardsiGC12P021590.
HGNCiHGNC:26162. PYROXD1.
HPAiHPA038319.
neXtProtiNX_Q8WU10.
PharmGKBiPA162400525.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0446.
GeneTreeiENSGT00390000014894.
HOGENOMiHOG000265662.
HOVERGENiHBG108313.
InParanoidiQ8WU10.
OMAiCEVIWAI.
OrthoDBiEOG71P29Z.
PhylomeDBiQ8WU10.
TreeFamiTF105963.

Miscellaneous databases

GenomeRNAii79912.
NextBioi35470454.
PROiQ8WU10.

Gene expression databases

BgeeiQ8WU10.
CleanExiHS_PYROXD1.
ExpressionAtlasiQ8WU10. baseline and differential.
GenevestigatoriQ8WU10.

Family and domain databases

InterProiIPR013027. FAD_pyr_nucl-diS_OxRdtase.
IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
[Graphical view]
PfamiPF07992. Pyr_redox_2. 1 hit.
[Graphical view]
PRINTSiPR00368. FADPNR.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain and Hepatoma.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Melanoma.
  3. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Kidney.
  6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPYRD1_HUMAN
AccessioniPrimary (citable) accession number: Q8WU10
Secondary accession number(s): A6NKI6, B3KWN8, Q9H6P1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: March 1, 2002
Last modified: February 4, 2015
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.