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Protein

Serine/threonine-protein kinase 32A

Gene

STK32A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.By similarity

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei52ATPPROSITE-ProRule annotationBy similarity1
Active sitei146Proton acceptorPROSITE-ProRule annotationBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi29 – 37ATPPROSITE-ProRule annotationBy similarity9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ8WU08

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase 32A (EC:2.7.11.1)
Alternative name(s):
Yet another novel kinase 1
Gene namesi
Name:STK32A
Synonyms:YANK1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000169302.14
HGNCiHGNC:28317 STK32A
neXtProtiNX_Q8WU08

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi2G → A: Localizes to cytoplasm. 1 Publication1

Organism-specific databases

DisGeNETi202374
OpenTargetsiENSG00000169302
PharmGKBiPA134932545

Chemistry databases

ChEMBLiCHEMBL6150
GuidetoPHARMACOLOGYi1537

Polymorphism and mutation databases

BioMutaiSTK32A
DMDMi93140693

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00002324112 – 396Serine/threonine-protein kinase 32AAdd BLAST395

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycine1 Publication1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

PaxDbiQ8WU08
PeptideAtlasiQ8WU08
PRIDEiQ8WU08
ProteomicsDBi74618
74619 [Q8WU08-2]
74620 [Q8WU08-3]

PTM databases

iPTMnetiQ8WU08
PhosphoSitePlusiQ8WU08

Expressioni

Gene expression databases

BgeeiENSG00000169302
CleanExiHS_STK32A
ExpressionAtlasiQ8WU08 baseline and differential
GenevisibleiQ8WU08 HS

Organism-specific databases

HPAiHPA040236

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CDC37Q165434EBI-13046508,EBI-295634

Protein-protein interaction databases

BioGridi128429, 2 interactors
IntActiQ8WU08, 1 interactor
STRINGi9606.ENSP00000381030

Chemistry databases

BindingDBiQ8WU08

Structurei

Secondary structure

1396
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi20 – 22Combined sources3
Beta strandi23 – 30Combined sources8
Beta strandi37 – 42Combined sources6
Turni43 – 45Combined sources3
Beta strandi48 – 55Combined sources8
Helixi56 – 61Combined sources6
Helixi65 – 76Combined sources12
Beta strandi86 – 91Combined sources6
Beta strandi93 – 100Combined sources8
Helixi108 – 113Combined sources6
Helixi120 – 139Combined sources20
Beta strandi151 – 154Combined sources4
Beta strandi160 – 162Combined sources3
Helixi184 – 186Combined sources3
Helixi189 – 191Combined sources3
Helixi204 – 218Combined sources15
Helixi231 – 240Combined sources10
Helixi251 – 260Combined sources10
Helixi265 – 267Combined sources3
Helixi272 – 276Combined sources5
Helixi279 – 281Combined sources3
Helixi286 – 290Combined sources5
Helixi343 – 358Combined sources16
Helixi364 – 369Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4FR4X-ray2.29A/B/C/D/E/F9-390[»]
ProteinModelPortaliQ8WU08
SMRiQ8WU08
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 281Protein kinasePROSITE-ProRule annotationAdd BLAST259

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0598 Eukaryota
ENOG410XNPH LUCA
GeneTreeiENSGT00920000148962
HOGENOMiHOG000021314
HOVERGENiHBG106458
InParanoidiQ8WU08
KOiK08793
PhylomeDBiQ8WU08
TreeFamiTF313395

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1Curated (identifier: Q8WU08-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGANTSRKPP VFDENEDVNF DHFEILRAIG KGSFGKVCIV QKNDTKKMYA
60 70 80 90 100
MKYMNKQKCV ERNEVRNVFK ELQIMQGLEH PFLVNLWYSF QDEEDMFMVV
110 120 130 140 150
DLLLGGDLRY HLQQNVHFKE ETVKLFICEL VMALDYLQNQ RIIHRDMKPD
160 170 180 190 200
NILLDEHGHV HITDFNIAAM LPRETQITTM AGTKPYMAPE MFSSRKGAGY
210 220 230 240 250
SFAVDWWSLG VTAYELLRGR RPYHIRSSTS SKEIVHTFET TVVTYPSAWS
260 270 280 290 300
QEMVSLLKKL LEPNPDQRFS QLSDVQNFPY MNDINWDAVF QKRLIPGFIP
310 320 330 340 350
NKGRLNCDPT FELEEMILES KPLHKKKKRL AKKEKDMRKC DSSQTCLLQE
360 370 380 390
HLDSVQKEFI IFNREKVNRD FNKRQPNLAL EQTKDPQGED GQNNNL
Length:396
Mass (Da):46,369
Last modified:April 18, 2006 - v2
Checksum:i5ED718F0D3A7A48C
GO
Isoform 21 Publication (identifier: Q8WU08-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     158-166: GHVHITDFN → DTWLSYKSH
     167-396: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:166
Mass (Da):19,792
Checksum:iCDCF94E54C793BA4
GO
Isoform 3Curated (identifier: Q8WU08-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     345-358: TCLLQEHLDSVQKE → VSRSPPNSGSWVSP
     359-396: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:358
Mass (Da):41,699
Checksum:i65A66B1C7627265A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04116358K → M1 PublicationCorresponds to variant dbSNP:rs35852718Ensembl.1
Natural variantiVAR_04116489S → F in a metastatic melanoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_041165316M → I in a lung neuroendocrine carcinoma sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_051992158 – 166GHVHITDFN → DTWLSYKSH in isoform 2. 1 Publication9
Alternative sequenceiVSP_051993167 – 396Missing in isoform 2. 1 PublicationAdd BLAST230
Alternative sequenceiVSP_051994345 – 358TCLLQ…SVQKE → VSRSPPNSGSWVSP in isoform 3. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_051995359 – 396Missing in isoform 3. 1 PublicationAdd BLAST38

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK094580 mRNA Translation: BAG52892.1
AC008740 Genomic DNA No translation available.
CH471062 Genomic DNA Translation: EAW61827.1
CCDSiCCDS47299.1 [Q8WU08-1]
CCDS54931.1 [Q8WU08-2]
RefSeqiNP_001106195.1, NM_001112724.1 [Q8WU08-1]
NP_659438.1, NM_145001.3 [Q8WU08-2]
UniGeneiHs.585069

Genome annotation databases

EnsembliENST00000397936; ENSP00000381030; ENSG00000169302 [Q8WU08-1]
ENST00000626951; ENSP00000487441; ENSG00000169302 [Q8WU08-2]
GeneIDi202374
KEGGihsa:202374
UCSCiuc010jgn.2 human [Q8WU08-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiST32A_HUMAN
AccessioniPrimary (citable) accession number: Q8WU08
Secondary accession number(s): B3KSY0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: April 18, 2006
Last modified: June 20, 2018
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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