SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8WU08

- ST32A_HUMAN

UniProt

Q8WU08 - ST32A_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Serine/threonine-protein kinase 32A
Gene
STK32A, YANK1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.By similarity

Cofactori

Magnesium By similarity.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei52 – 521ATP By similarityBy similarity
Active sitei146 – 1461Proton acceptor By similarityBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi29 – 379ATP By similarityBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. protein serine/threonine kinase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ8WU08.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase 32A (EC:2.7.11.1)
Alternative name(s):
Yet another novel kinase 1
Gene namesi
Name:STK32A
Synonyms:YANK1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:28317. STK32A.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134932545.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 396396Serine/threonine-protein kinase 32A
PRO_0000232411Add
BLAST

Proteomic databases

PaxDbiQ8WU08.
PRIDEiQ8WU08.

PTM databases

PhosphoSiteiQ8WU08.

Expressioni

Gene expression databases

ArrayExpressiQ8WU08.
BgeeiQ8WU08.
CleanExiHS_STK32A.
GenevestigatoriQ8WU08.

Organism-specific databases

HPAiHPA040236.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000381030.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi20 – 223
Beta strandi23 – 308
Beta strandi37 – 426
Turni43 – 453
Beta strandi48 – 558
Helixi56 – 616
Helixi65 – 7612
Beta strandi86 – 916
Beta strandi93 – 1008
Helixi108 – 1136
Helixi120 – 13920
Beta strandi151 – 1544
Beta strandi160 – 1623
Helixi184 – 1863
Helixi189 – 1913
Helixi204 – 21815
Helixi231 – 24010
Helixi251 – 26010
Helixi265 – 2673
Helixi272 – 2765
Helixi279 – 2813
Helixi286 – 2905
Helixi343 – 35816
Helixi364 – 3696

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4FR4X-ray2.29A/B/C/D/E/F9-390[»]
ProteinModelPortaliQ8WU08.
SMRiQ8WU08. Positions 14-373.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 281259Protein kinase
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000021314.
HOVERGENiHBG106458.
InParanoidiQ8WU08.
KOiK08793.
OrthoDBiEOG7RZ5Q0.
PhylomeDBiQ8WU08.
TreeFamiTF313395.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8WU08-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGANTSRKPP VFDENEDVNF DHFEILRAIG KGSFGKVCIV QKNDTKKMYA    50
MKYMNKQKCV ERNEVRNVFK ELQIMQGLEH PFLVNLWYSF QDEEDMFMVV 100
DLLLGGDLRY HLQQNVHFKE ETVKLFICEL VMALDYLQNQ RIIHRDMKPD 150
NILLDEHGHV HITDFNIAAM LPRETQITTM AGTKPYMAPE MFSSRKGAGY 200
SFAVDWWSLG VTAYELLRGR RPYHIRSSTS SKEIVHTFET TVVTYPSAWS 250
QEMVSLLKKL LEPNPDQRFS QLSDVQNFPY MNDINWDAVF QKRLIPGFIP 300
NKGRLNCDPT FELEEMILES KPLHKKKKRL AKKEKDMRKC DSSQTCLLQE 350
HLDSVQKEFI IFNREKVNRD FNKRQPNLAL EQTKDPQGED GQNNNL 396
Length:396
Mass (Da):46,369
Last modified:April 18, 2006 - v2
Checksum:i5ED718F0D3A7A48C
GO
Isoform 21 Publication (identifier: Q8WU08-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     158-166: GHVHITDFN → DTWLSYKSH
     167-396: Missing.

Note: No experimental confirmation available.

Show »
Length:166
Mass (Da):19,792
Checksum:iCDCF94E54C793BA4
GO
Isoform 3 (identifier: Q8WU08-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     345-358: TCLLQEHLDSVQKE → VSRSPPNSGSWVSP
     359-396: Missing.

Note: No experimental confirmation available.

Show »
Length:358
Mass (Da):41,699
Checksum:i65A66B1C7627265A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti58 – 581K → M.1 Publication
Corresponds to variant rs35852718 [ dbSNP | Ensembl ].
VAR_041163
Natural varianti89 – 891S → F in a metastatic melanoma sample; somatic mutation. 1 Publication
VAR_041164
Natural varianti316 – 3161M → I in a lung neuroendocrine carcinoma sample; somatic mutation. 1 Publication
VAR_041165

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei158 – 1669GHVHITDFN → DTWLSYKSH in isoform 2.
VSP_051992
Alternative sequencei167 – 396230Missing in isoform 2. 1 Publication
VSP_051993Add
BLAST
Alternative sequencei345 – 35814TCLLQ…SVQKE → VSRSPPNSGSWVSP in isoform 3.
VSP_051994Add
BLAST
Alternative sequencei359 – 39638Missing in isoform 3.
VSP_051995Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK094580 mRNA. Translation: BAG52892.1.
AC008740 Genomic DNA. No translation available.
CH471062 Genomic DNA. Translation: EAW61827.1.
CCDSiCCDS47299.1. [Q8WU08-1]
CCDS54931.1. [Q8WU08-2]
RefSeqiNP_001106195.1. NM_001112724.1. [Q8WU08-1]
NP_659438.1. NM_145001.3. [Q8WU08-2]
UniGeneiHs.585069.

Genome annotation databases

EnsembliENST00000397936; ENSP00000381030; ENSG00000169302. [Q8WU08-1]
ENST00000541094; ENSP00000443156; ENSG00000169302. [Q8WU08-2]
GeneIDi202374.
KEGGihsa:202374.
UCSCiuc003lol.4. human. [Q8WU08-2]
uc003lom.2. human. [Q8WU08-3]
uc010jgn.1. human. [Q8WU08-1]

Polymorphism databases

DMDMi93140693.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK094580 mRNA. Translation: BAG52892.1 .
AC008740 Genomic DNA. No translation available.
CH471062 Genomic DNA. Translation: EAW61827.1 .
CCDSi CCDS47299.1. [Q8WU08-1 ]
CCDS54931.1. [Q8WU08-2 ]
RefSeqi NP_001106195.1. NM_001112724.1. [Q8WU08-1 ]
NP_659438.1. NM_145001.3. [Q8WU08-2 ]
UniGenei Hs.585069.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4FR4 X-ray 2.29 A/B/C/D/E/F 9-390 [» ]
ProteinModelPortali Q8WU08.
SMRi Q8WU08. Positions 14-373.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000381030.

Chemistry

BindingDBi Q8WU08.
ChEMBLi CHEMBL6150.
GuidetoPHARMACOLOGYi 1537.

PTM databases

PhosphoSitei Q8WU08.

Polymorphism databases

DMDMi 93140693.

Proteomic databases

PaxDbi Q8WU08.
PRIDEi Q8WU08.

Protocols and materials databases

DNASUi 202374.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000397936 ; ENSP00000381030 ; ENSG00000169302 . [Q8WU08-1 ]
ENST00000541094 ; ENSP00000443156 ; ENSG00000169302 . [Q8WU08-2 ]
GeneIDi 202374.
KEGGi hsa:202374.
UCSCi uc003lol.4. human. [Q8WU08-2 ]
uc003lom.2. human. [Q8WU08-3 ]
uc010jgn.1. human. [Q8WU08-1 ]

Organism-specific databases

CTDi 202374.
GeneCardsi GC05P146594.
H-InvDB HIX0005283.
HGNCi HGNC:28317. STK32A.
HPAi HPA040236.
neXtProti NX_Q8WU08.
PharmGKBi PA134932545.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000021314.
HOVERGENi HBG106458.
InParanoidi Q8WU08.
KOi K08793.
OrthoDBi EOG7RZ5Q0.
PhylomeDBi Q8WU08.
TreeFami TF313395.

Enzyme and pathway databases

SignaLinki Q8WU08.

Miscellaneous databases

GenomeRNAii 202374.
NextBioi 90285.
PROi Q8WU08.

Gene expression databases

ArrayExpressi Q8WU08.
Bgeei Q8WU08.
CleanExi HS_STK32A.
Genevestigatori Q8WU08.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), NOMENCLATURE.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Amygdala.
  3. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Urinary bladder.
  5. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS [LARGE SCALE ANALYSIS] MET-58; PHE-89 AND ILE-316.

Entry informationi

Entry nameiST32A_HUMAN
AccessioniPrimary (citable) accession number: Q8WU08
Secondary accession number(s): B3KSY0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: April 18, 2006
Last modified: July 9, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi