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Protein

Serine/threonine-protein kinase 32A

Gene

STK32A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.By similarity

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei52ATPPROSITE-ProRule annotationBy similarity1
Active sitei146Proton acceptorPROSITE-ProRule annotationBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi29 – 37ATPPROSITE-ProRule annotationBy similarity9

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:HS09925-MONOMER.
SignaLinkiQ8WU08.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase 32A (EC:2.7.11.1)
Alternative name(s):
Yet another novel kinase 1
Gene namesi
Name:STK32A
Synonyms:YANK1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:28317. STK32A.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi2G → A: Localizes to cytoplasm. 1 Publication1

Organism-specific databases

DisGeNETi202374.
OpenTargetsiENSG00000169302.
PharmGKBiPA134932545.

Chemistry databases

ChEMBLiCHEMBL6150.
GuidetoPHARMACOLOGYi1537.

Polymorphism and mutation databases

BioMutaiSTK32A.
DMDMi93140693.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00002324112 – 396Serine/threonine-protein kinase 32AAdd BLAST395

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycine1 Publication1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

PaxDbiQ8WU08.
PeptideAtlasiQ8WU08.
PRIDEiQ8WU08.

PTM databases

iPTMnetiQ8WU08.
PhosphoSitePlusiQ8WU08.

Expressioni

Gene expression databases

BgeeiENSG00000169302.
CleanExiHS_STK32A.
ExpressionAtlasiQ8WU08. baseline and differential.
GenevisibleiQ8WU08. HS.

Organism-specific databases

HPAiHPA040236.

Interactioni

Protein-protein interaction databases

BioGridi128429. 2 interactors.
STRINGi9606.ENSP00000381030.

Chemistry databases

BindingDBiQ8WU08.

Structurei

Secondary structure

1396
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi20 – 22Combined sources3
Beta strandi23 – 30Combined sources8
Beta strandi37 – 42Combined sources6
Turni43 – 45Combined sources3
Beta strandi48 – 55Combined sources8
Helixi56 – 61Combined sources6
Helixi65 – 76Combined sources12
Beta strandi86 – 91Combined sources6
Beta strandi93 – 100Combined sources8
Helixi108 – 113Combined sources6
Helixi120 – 139Combined sources20
Beta strandi151 – 154Combined sources4
Beta strandi160 – 162Combined sources3
Helixi184 – 186Combined sources3
Helixi189 – 191Combined sources3
Helixi204 – 218Combined sources15
Helixi231 – 240Combined sources10
Helixi251 – 260Combined sources10
Helixi265 – 267Combined sources3
Helixi272 – 276Combined sources5
Helixi279 – 281Combined sources3
Helixi286 – 290Combined sources5
Helixi343 – 358Combined sources16
Helixi364 – 369Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4FR4X-ray2.29A/B/C/D/E/F9-390[»]
ProteinModelPortaliQ8WU08.
SMRiQ8WU08.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 281Protein kinasePROSITE-ProRule annotationAdd BLAST259

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0598. Eukaryota.
ENOG410XNPH. LUCA.
GeneTreeiENSGT00860000133734.
HOGENOMiHOG000021314.
HOVERGENiHBG106458.
InParanoidiQ8WU08.
KOiK08793.
PhylomeDBiQ8WU08.
TreeFamiTF313395.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1Curated (identifier: Q8WU08-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGANTSRKPP VFDENEDVNF DHFEILRAIG KGSFGKVCIV QKNDTKKMYA
60 70 80 90 100
MKYMNKQKCV ERNEVRNVFK ELQIMQGLEH PFLVNLWYSF QDEEDMFMVV
110 120 130 140 150
DLLLGGDLRY HLQQNVHFKE ETVKLFICEL VMALDYLQNQ RIIHRDMKPD
160 170 180 190 200
NILLDEHGHV HITDFNIAAM LPRETQITTM AGTKPYMAPE MFSSRKGAGY
210 220 230 240 250
SFAVDWWSLG VTAYELLRGR RPYHIRSSTS SKEIVHTFET TVVTYPSAWS
260 270 280 290 300
QEMVSLLKKL LEPNPDQRFS QLSDVQNFPY MNDINWDAVF QKRLIPGFIP
310 320 330 340 350
NKGRLNCDPT FELEEMILES KPLHKKKKRL AKKEKDMRKC DSSQTCLLQE
360 370 380 390
HLDSVQKEFI IFNREKVNRD FNKRQPNLAL EQTKDPQGED GQNNNL
Length:396
Mass (Da):46,369
Last modified:April 18, 2006 - v2
Checksum:i5ED718F0D3A7A48C
GO
Isoform 21 Publication (identifier: Q8WU08-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     158-166: GHVHITDFN → DTWLSYKSH
     167-396: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:166
Mass (Da):19,792
Checksum:iCDCF94E54C793BA4
GO
Isoform 3Curated (identifier: Q8WU08-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     345-358: TCLLQEHLDSVQKE → VSRSPPNSGSWVSP
     359-396: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:358
Mass (Da):41,699
Checksum:i65A66B1C7627265A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04116358K → M.1 PublicationCorresponds to variant rs35852718dbSNPEnsembl.1
Natural variantiVAR_04116489S → F in a metastatic melanoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_041165316M → I in a lung neuroendocrine carcinoma sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_051992158 – 166GHVHITDFN → DTWLSYKSH in isoform 2. 1 Publication9
Alternative sequenceiVSP_051993167 – 396Missing in isoform 2. 1 PublicationAdd BLAST230
Alternative sequenceiVSP_051994345 – 358TCLLQ…SVQKE → VSRSPPNSGSWVSP in isoform 3. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_051995359 – 396Missing in isoform 3. 1 PublicationAdd BLAST38

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK094580 mRNA. Translation: BAG52892.1.
AC008740 Genomic DNA. No translation available.
CH471062 Genomic DNA. Translation: EAW61827.1.
CCDSiCCDS47299.1. [Q8WU08-1]
CCDS54931.1. [Q8WU08-2]
RefSeqiNP_001106195.1. NM_001112724.1. [Q8WU08-1]
NP_659438.1. NM_145001.3. [Q8WU08-2]
UniGeneiHs.585069.

Genome annotation databases

EnsembliENST00000397936; ENSP00000381030; ENSG00000169302. [Q8WU08-1]
ENST00000626951; ENSP00000487441; ENSG00000169302. [Q8WU08-2]
GeneIDi202374.
KEGGihsa:202374.
UCSCiuc010jgn.2. human. [Q8WU08-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK094580 mRNA. Translation: BAG52892.1.
AC008740 Genomic DNA. No translation available.
CH471062 Genomic DNA. Translation: EAW61827.1.
CCDSiCCDS47299.1. [Q8WU08-1]
CCDS54931.1. [Q8WU08-2]
RefSeqiNP_001106195.1. NM_001112724.1. [Q8WU08-1]
NP_659438.1. NM_145001.3. [Q8WU08-2]
UniGeneiHs.585069.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4FR4X-ray2.29A/B/C/D/E/F9-390[»]
ProteinModelPortaliQ8WU08.
SMRiQ8WU08.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128429. 2 interactors.
STRINGi9606.ENSP00000381030.

Chemistry databases

BindingDBiQ8WU08.
ChEMBLiCHEMBL6150.
GuidetoPHARMACOLOGYi1537.

PTM databases

iPTMnetiQ8WU08.
PhosphoSitePlusiQ8WU08.

Polymorphism and mutation databases

BioMutaiSTK32A.
DMDMi93140693.

Proteomic databases

PaxDbiQ8WU08.
PeptideAtlasiQ8WU08.
PRIDEiQ8WU08.

Protocols and materials databases

DNASUi202374.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000397936; ENSP00000381030; ENSG00000169302. [Q8WU08-1]
ENST00000626951; ENSP00000487441; ENSG00000169302. [Q8WU08-2]
GeneIDi202374.
KEGGihsa:202374.
UCSCiuc010jgn.2. human. [Q8WU08-1]

Organism-specific databases

CTDi202374.
DisGeNETi202374.
GeneCardsiSTK32A.
H-InvDBHIX0005283.
HGNCiHGNC:28317. STK32A.
HPAiHPA040236.
neXtProtiNX_Q8WU08.
OpenTargetsiENSG00000169302.
PharmGKBiPA134932545.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0598. Eukaryota.
ENOG410XNPH. LUCA.
GeneTreeiENSGT00860000133734.
HOGENOMiHOG000021314.
HOVERGENiHBG106458.
InParanoidiQ8WU08.
KOiK08793.
PhylomeDBiQ8WU08.
TreeFamiTF313395.

Enzyme and pathway databases

BioCyciZFISH:HS09925-MONOMER.
SignaLinkiQ8WU08.

Miscellaneous databases

GenomeRNAii202374.
PROiQ8WU08.

Gene expression databases

BgeeiENSG00000169302.
CleanExiHS_STK32A.
ExpressionAtlasiQ8WU08. baseline and differential.
GenevisibleiQ8WU08. HS.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiST32A_HUMAN
AccessioniPrimary (citable) accession number: Q8WU08
Secondary accession number(s): B3KSY0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: April 18, 2006
Last modified: November 30, 2016
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.