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Q8WU08

- ST32A_HUMAN

UniProt

Q8WU08 - ST32A_HUMAN

Protein

Serine/threonine-protein kinase 32A

Gene

STK32A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 2 (18 Apr 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.By similarity

    Cofactori

    Magnesium.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei52 – 521ATPBy similarityPROSITE-ProRule annotation
    Active sitei146 – 1461Proton acceptorBy similarityPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi29 – 379ATPBy similarityPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. protein serine/threonine kinase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    SignaLinkiQ8WU08.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein kinase 32A (EC:2.7.11.1)
    Alternative name(s):
    Yet another novel kinase 1
    Gene namesi
    Name:STK32A
    Synonyms:YANK1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:28317. STK32A.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134932545.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 396396Serine/threonine-protein kinase 32APRO_0000232411Add
    BLAST

    Proteomic databases

    PaxDbiQ8WU08.
    PRIDEiQ8WU08.

    PTM databases

    PhosphoSiteiQ8WU08.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8WU08.
    BgeeiQ8WU08.
    CleanExiHS_STK32A.
    GenevestigatoriQ8WU08.

    Organism-specific databases

    HPAiHPA040236.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000381030.

    Structurei

    Secondary structure

    1
    396
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi20 – 223
    Beta strandi23 – 308
    Beta strandi37 – 426
    Turni43 – 453
    Beta strandi48 – 558
    Helixi56 – 616
    Helixi65 – 7612
    Beta strandi86 – 916
    Beta strandi93 – 1008
    Helixi108 – 1136
    Helixi120 – 13920
    Beta strandi151 – 1544
    Beta strandi160 – 1623
    Helixi184 – 1863
    Helixi189 – 1913
    Helixi204 – 21815
    Helixi231 – 24010
    Helixi251 – 26010
    Helixi265 – 2673
    Helixi272 – 2765
    Helixi279 – 2813
    Helixi286 – 2905
    Helixi343 – 35816
    Helixi364 – 3696

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4FR4X-ray2.29A/B/C/D/E/F9-390[»]
    ProteinModelPortaliQ8WU08.
    SMRiQ8WU08. Positions 14-373.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini23 – 281259Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000021314.
    HOVERGENiHBG106458.
    InParanoidiQ8WU08.
    KOiK08793.
    OrthoDBiEOG7RZ5Q0.
    PhylomeDBiQ8WU08.
    TreeFamiTF313395.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1Curated (identifier: Q8WU08-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGANTSRKPP VFDENEDVNF DHFEILRAIG KGSFGKVCIV QKNDTKKMYA    50
    MKYMNKQKCV ERNEVRNVFK ELQIMQGLEH PFLVNLWYSF QDEEDMFMVV 100
    DLLLGGDLRY HLQQNVHFKE ETVKLFICEL VMALDYLQNQ RIIHRDMKPD 150
    NILLDEHGHV HITDFNIAAM LPRETQITTM AGTKPYMAPE MFSSRKGAGY 200
    SFAVDWWSLG VTAYELLRGR RPYHIRSSTS SKEIVHTFET TVVTYPSAWS 250
    QEMVSLLKKL LEPNPDQRFS QLSDVQNFPY MNDINWDAVF QKRLIPGFIP 300
    NKGRLNCDPT FELEEMILES KPLHKKKKRL AKKEKDMRKC DSSQTCLLQE 350
    HLDSVQKEFI IFNREKVNRD FNKRQPNLAL EQTKDPQGED GQNNNL 396
    Length:396
    Mass (Da):46,369
    Last modified:April 18, 2006 - v2
    Checksum:i5ED718F0D3A7A48C
    GO
    Isoform 21 Publication (identifier: Q8WU08-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         158-166: GHVHITDFN → DTWLSYKSH
         167-396: Missing.

    Note: No experimental confirmation available.Curated

    Show »
    Length:166
    Mass (Da):19,792
    Checksum:iCDCF94E54C793BA4
    GO
    Isoform 3Curated (identifier: Q8WU08-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         345-358: TCLLQEHLDSVQKE → VSRSPPNSGSWVSP
         359-396: Missing.

    Note: No experimental confirmation available.Curated

    Show »
    Length:358
    Mass (Da):41,699
    Checksum:i65A66B1C7627265A
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti58 – 581K → M.1 Publication
    Corresponds to variant rs35852718 [ dbSNP | Ensembl ].
    VAR_041163
    Natural varianti89 – 891S → F in a metastatic melanoma sample; somatic mutation. 1 Publication
    VAR_041164
    Natural varianti316 – 3161M → I in a lung neuroendocrine carcinoma sample; somatic mutation. 1 Publication
    VAR_041165

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei158 – 1669GHVHITDFN → DTWLSYKSH in isoform 2. 1 PublicationVSP_051992
    Alternative sequencei167 – 396230Missing in isoform 2. 1 PublicationVSP_051993Add
    BLAST
    Alternative sequencei345 – 35814TCLLQ…SVQKE → VSRSPPNSGSWVSP in isoform 3. 1 PublicationVSP_051994Add
    BLAST
    Alternative sequencei359 – 39638Missing in isoform 3. 1 PublicationVSP_051995Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK094580 mRNA. Translation: BAG52892.1.
    AC008740 Genomic DNA. No translation available.
    CH471062 Genomic DNA. Translation: EAW61827.1.
    CCDSiCCDS47299.1. [Q8WU08-1]
    CCDS54931.1. [Q8WU08-2]
    RefSeqiNP_001106195.1. NM_001112724.1. [Q8WU08-1]
    NP_659438.1. NM_145001.3. [Q8WU08-2]
    UniGeneiHs.585069.

    Genome annotation databases

    EnsembliENST00000397936; ENSP00000381030; ENSG00000169302. [Q8WU08-1]
    GeneIDi202374.
    KEGGihsa:202374.
    UCSCiuc003lol.4. human. [Q8WU08-2]
    uc003lom.2. human. [Q8WU08-3]
    uc010jgn.1. human. [Q8WU08-1]

    Polymorphism databases

    DMDMi93140693.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK094580 mRNA. Translation: BAG52892.1 .
    AC008740 Genomic DNA. No translation available.
    CH471062 Genomic DNA. Translation: EAW61827.1 .
    CCDSi CCDS47299.1. [Q8WU08-1 ]
    CCDS54931.1. [Q8WU08-2 ]
    RefSeqi NP_001106195.1. NM_001112724.1. [Q8WU08-1 ]
    NP_659438.1. NM_145001.3. [Q8WU08-2 ]
    UniGenei Hs.585069.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4FR4 X-ray 2.29 A/B/C/D/E/F 9-390 [» ]
    ProteinModelPortali Q8WU08.
    SMRi Q8WU08. Positions 14-373.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000381030.

    Chemistry

    BindingDBi Q8WU08.
    ChEMBLi CHEMBL6150.
    GuidetoPHARMACOLOGYi 1537.

    PTM databases

    PhosphoSitei Q8WU08.

    Polymorphism databases

    DMDMi 93140693.

    Proteomic databases

    PaxDbi Q8WU08.
    PRIDEi Q8WU08.

    Protocols and materials databases

    DNASUi 202374.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000397936 ; ENSP00000381030 ; ENSG00000169302 . [Q8WU08-1 ]
    GeneIDi 202374.
    KEGGi hsa:202374.
    UCSCi uc003lol.4. human. [Q8WU08-2 ]
    uc003lom.2. human. [Q8WU08-3 ]
    uc010jgn.1. human. [Q8WU08-1 ]

    Organism-specific databases

    CTDi 202374.
    GeneCardsi GC05P146594.
    H-InvDB HIX0005283.
    HGNCi HGNC:28317. STK32A.
    HPAi HPA040236.
    neXtProti NX_Q8WU08.
    PharmGKBi PA134932545.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000021314.
    HOVERGENi HBG106458.
    InParanoidi Q8WU08.
    KOi K08793.
    OrthoDBi EOG7RZ5Q0.
    PhylomeDBi Q8WU08.
    TreeFami TF313395.

    Enzyme and pathway databases

    SignaLinki Q8WU08.

    Miscellaneous databases

    GenomeRNAii 202374.
    NextBioi 90285.
    PROi Q8WU08.

    Gene expression databases

    ArrayExpressi Q8WU08.
    Bgeei Q8WU08.
    CleanExi HS_STK32A.
    Genevestigatori Q8WU08.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), NOMENCLATURE.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Amygdala1 Publication.
    3. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Urinary bladder.
    5. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS [LARGE SCALE ANALYSIS] MET-58; PHE-89 AND ILE-316.

    Entry informationi

    Entry nameiST32A_HUMAN
    AccessioniPrimary (citable) accession number: Q8WU08
    Secondary accession number(s): B3KSY0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 18, 2006
    Last sequence update: April 18, 2006
    Last modified: October 1, 2014
    This is version 110 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    5. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3