Q8WU03 (GLYL2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glycine N-acyltransferase-like protein 2
EC=2.3.1.13

Alternative name(s):
Acyl-CoA:glycine N-acyltransferase-like protein 2

Gene names

Name:

GLYATL2

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	294 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Mitochondrial acyltransferase which transfers the acyl group to the N-terminus of glycine. Can conjugate a multitude of substrates to form a variety of N-acylglycines By similarity.
Catalytic activity	Acyl-CoA + glycine = CoA + N-acylglycine.
Subcellular location	Mitochondrion By similarity.
Sequence similarities	Belongs to the glycine N-acyltransferase family.

Ontologies

Keywords
Cellular component	Mitochondrion
Coding sequence diversity	Polymorphism
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glycine N-acyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 294	294	Glycine N-acyltransferase-like protein 2		PRO_0000281875
Natural variations
	Natural variant	82	1	P → S. Ref.2 Corresponds to variant rs17856514 [ dbSNP | Ensembl ].		VAR_031296
	Natural variant	160	1	E → K. Ref.1 Corresponds to variant rs11229651 [ dbSNP | Ensembl ].		VAR_031297
	Natural variant	168	1	L → I. Ref.2 Corresponds to variant rs17851433 [ dbSNP | Ensembl ].		VAR_031298
Experimental info
	Sequence conflict	219	1	Q → R in AAO73139. Ref.1
	Sequence conflict	293	1	Y → C in AAO73139. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q8WU03 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: A1F5C3EC989D90D1	FASTA	294	34,277
	10 20 30 40 50 60 MLVLHNSQKL QILYKSLEKS IPESIKVYGA IFNIKDKNPF NMEVLVDAWP DYQIVITRPQ 70 80 90 100 110 120 KQEMKDDQDH YTNTYHIFTK APDKLEEVLS YSNVISWEQT LQIQGCQEGL DEAIRKVATS 130 140 150 160 170 180 KSVQVDYMKT ILFIPELPKK HKTSSNDKME LFEVDDDNKE GNFSNMFLDA SHAGLVNEHW 190 200 210 220 230 240 AFGKNERSLK YIERCLQDFL GFGVLGPEGQ LVSWIVMEQS CELRMGYTVP KYRHQGNMLQ 250 260 270 280 290 IGYHLEKYLS QKEIPFYFHV ADNNEKSLQA LNNLGFKICP CGWHQWKCTP KKYC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation of a novel BXMAS2-10 gene from IgM cross-linking induced human B cell." Nakayama Y., Weissman S.M., Bothwell A.L. Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT LYS-160.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS SER-82 AND ILE-168. Tissue: Bone marrow.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF426250 mRNA. Translation: AAO73139.1. BC016789 mRNA. Translation: AAH16789.1. BC021682 mRNA. Translation: AAH21682.1.
IPI	IPI00102799.
RefSeq	NP_659453.3. NM_145016.3.
UniGene	Hs.254271.
3D structure databases
ProteinModelPortal	Q8WU03.
SMR	Q8WU03. Positions 199-280.
ModBase	Search...
PTM databases
PhosphoSite	Q8WU03.
Polymorphism databases
DMDM	74730653.
Proteomic databases
PRIDE	Q8WU03.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000287275; ENSP00000287275; ENSG00000156689.
GeneID	219970.
KEGG	hsa:219970.
UCSC	uc001nnd.2. human.
Organism-specific databases
CTD	219970.
GeneCards	GC11M058601.
HGNC	HGNC:24178. GLYATL2.
neXtProt	NX_Q8WU03.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG04251.
GeneTree	ENSGT00390000004997.
HOGENOM	HBG506867.
HOVERGEN	HBG107953.
InParanoid	Q8WU03.
OMA	NERSLKY.
OrthoDB	EOG47PX66.
PhylomeDB	Q8WU03.
Gene expression databases
ArrayExpress	Q8WU03.
Bgee	Q8WU03.
CleanEx	HS_GLYATL2.
Genevestigator	Q8WU03.
Family and domain databases
InterPro	IPR016181. Acyl_CoA_acyltransferase. IPR010313. Glycine_N-acyltransferase. IPR013652. Glycine_N-acyltransferase_C. IPR015938. Glycine_N-acyltransferase_N. [Graphical view]
Gene3D	G3DSA:3.40.630.30. Acyl_CoA_acyltransferase. 1 hit.
PANTHER	PTHR15298. Glycine_acyl_tr. 1 hit.
Pfam	PF08444. Gly_acyl_tr_C. 1 hit. PF06021. Gly_acyl_tr_N. 1 hit. [Graphical view]
SUPFAM	SSF55729. Acyl_CoA_acyltransferase. 1 hit.
ProtoNet	Search...
Other
DrugBank	DB00145. Glycine.
NextBio	90902.

Entry information

Entry name

GLYL2_HUMAN

Accession

Primary (citable) accession number: Q8WU03
Secondary accession number(s): Q86WC3, Q96AT2

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 3, 2007
Last sequence update:	March 1, 2002
Last modified:	January 25, 2012
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.