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Protein

Glycine N-acyltransferase-like protein 2

Gene

GLYATL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Mitochondrial acyltransferase which transfers the acyl group to the N-terminus of glycine. Conjugates numerous substrates, such as arachidonoyl-CoA and saturated medium and long-chain acyl-CoAs ranging from chain-length C8:0-CoA to C18:0-CoA, to form a variety of N-acylglycines. Shows a preference for monounsaturated fatty acid oleoyl-CoA (C18:1-CoA) as an acyl donor. Does not exhibit any activity toward C22:6-CoA and chenodeoxycholoyl-CoA, nor toward serine or alanine.1 Publication

Catalytic activityi

Acyl-CoA + glycine = CoA + N-acylglycine.

Kineticsi

  1. KM=4.4 µM for oleoyl-CoA1 Publication
  1. Vmax=933 nmol/min/mg enzyme with oleoyl-CoA as substrate1 Publication

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.3.1.13. 2681.
ReactomeiR-HSA-177128. Conjugation of salicylate with glycine.
R-HSA-177135. Conjugation of benzoate with glycine.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine N-acyltransferase-like protein 2 (EC:2.3.1.13)
Alternative name(s):
Acyl-CoA:glycine N-acyltransferase-like protein 2
Gene namesi
Name:GLYATL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:24178. GLYATL2.

Subcellular locationi

  • Endoplasmic reticulum 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671728.

Chemistry

DrugBankiDB00145. Glycine.

Polymorphism and mutation databases

BioMutaiGLYATL2.
DMDMi74730653.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 294294Glycine N-acyltransferase-like protein 2PRO_0000281875Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei19 – 191N6-acetyllysine1 Publication

Post-translational modificationi

Acetylation at Lys-19 drastically decreases the production of N-oleoyl and N-arachidonoyl glycines.1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ8WU03.
PeptideAtlasiQ8WU03.
PRIDEiQ8WU03.

PTM databases

iPTMnetiQ8WU03.
PhosphoSiteiQ8WU03.

Expressioni

Tissue specificityi

Expressed at highest levels in salivary gland and trachea. Also detected in thyroid gland, spinal cord, prostate, lung and fetal brain.1 Publication

Gene expression databases

BgeeiENSG00000156689.
CleanExiHS_GLYATL2.
ExpressionAtlasiQ8WU03. baseline and differential.
GenevisibleiQ8WU03. HS.

Organism-specific databases

HPAiHPA060292.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000287275.

Structurei

3D structure databases

ProteinModelPortaliQ8WU03.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycine N-acyltransferase family.Curated

Phylogenomic databases

eggNOGiENOG410J98B. Eukaryota.
ENOG4111RDK. LUCA.
GeneTreeiENSGT00390000004997.
HOGENOMiHOG000263599.
HOVERGENiHBG107953.
InParanoidiQ8WU03.
OMAiMEQSCEL.
OrthoDBiEOG091G0GJJ.
PhylomeDBiQ8WU03.
TreeFamiTF353258.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR010313. Glycine_N-acyltransferase.
IPR013652. Glycine_N-acyltransferase_C.
IPR015938. Glycine_N-acyltransferase_N.
[Graphical view]
PANTHERiPTHR15298. PTHR15298. 1 hit.
PfamiPF08444. Gly_acyl_tr_C. 1 hit.
PF06021. Gly_acyl_tr_N. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8WU03-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVLHNSQKL QILYKSLEKS IPESIKVYGA IFNIKDKNPF NMEVLVDAWP
60 70 80 90 100
DYQIVITRPQ KQEMKDDQDH YTNTYHIFTK APDKLEEVLS YSNVISWEQT
110 120 130 140 150
LQIQGCQEGL DEAIRKVATS KSVQVDYMKT ILFIPELPKK HKTSSNDKME
160 170 180 190 200
LFEVDDDNKE GNFSNMFLDA SHAGLVNEHW AFGKNERSLK YIERCLQDFL
210 220 230 240 250
GFGVLGPEGQ LVSWIVMEQS CELRMGYTVP KYRHQGNMLQ IGYHLEKYLS
260 270 280 290
QKEIPFYFHV ADNNEKSLQA LNNLGFKICP CGWHQWKCTP KKYC
Length:294
Mass (Da):34,277
Last modified:March 1, 2002 - v1
Checksum:iA1F5C3EC989D90D1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti219 – 2191Q → R in AAO73139 (Ref. 1) Curated
Sequence conflicti293 – 2931Y → C in AAO73139 (Ref. 1) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti82 – 821P → S.1 Publication
Corresponds to variant rs17856514 [ dbSNP | Ensembl ].
VAR_031296
Natural varianti160 – 1601E → K.1 Publication
Corresponds to variant rs11229651 [ dbSNP | Ensembl ].
VAR_031297
Natural varianti168 – 1681L → I.1 Publication
Corresponds to variant rs17851433 [ dbSNP | Ensembl ].
VAR_031298

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF426250 mRNA. Translation: AAO73139.1.
AB207211 mRNA. Translation: BAF63415.1.
CH471076 Genomic DNA. Translation: EAW73826.1.
BC016789 mRNA. Translation: AAH16789.1.
BC021682 mRNA. Translation: AAH21682.1.
CCDSiCCDS41649.1.
RefSeqiNP_659453.3. NM_145016.3.
UniGeneiHs.254271.

Genome annotation databases

EnsembliENST00000287275; ENSP00000287275; ENSG00000156689.
ENST00000532258; ENSP00000434277; ENSG00000156689.
GeneIDi219970.
KEGGihsa:219970.
UCSCiuc001nnd.6. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF426250 mRNA. Translation: AAO73139.1.
AB207211 mRNA. Translation: BAF63415.1.
CH471076 Genomic DNA. Translation: EAW73826.1.
BC016789 mRNA. Translation: AAH16789.1.
BC021682 mRNA. Translation: AAH21682.1.
CCDSiCCDS41649.1.
RefSeqiNP_659453.3. NM_145016.3.
UniGeneiHs.254271.

3D structure databases

ProteinModelPortaliQ8WU03.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000287275.

Chemistry

DrugBankiDB00145. Glycine.

PTM databases

iPTMnetiQ8WU03.
PhosphoSiteiQ8WU03.

Polymorphism and mutation databases

BioMutaiGLYATL2.
DMDMi74730653.

Proteomic databases

PaxDbiQ8WU03.
PeptideAtlasiQ8WU03.
PRIDEiQ8WU03.

Protocols and materials databases

DNASUi219970.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000287275; ENSP00000287275; ENSG00000156689.
ENST00000532258; ENSP00000434277; ENSG00000156689.
GeneIDi219970.
KEGGihsa:219970.
UCSCiuc001nnd.6. human.

Organism-specific databases

CTDi219970.
GeneCardsiGLYATL2.
HGNCiHGNC:24178. GLYATL2.
HPAiHPA060292.
MIMi614762. gene.
neXtProtiNX_Q8WU03.
PharmGKBiPA142671728.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J98B. Eukaryota.
ENOG4111RDK. LUCA.
GeneTreeiENSGT00390000004997.
HOGENOMiHOG000263599.
HOVERGENiHBG107953.
InParanoidiQ8WU03.
OMAiMEQSCEL.
OrthoDBiEOG091G0GJJ.
PhylomeDBiQ8WU03.
TreeFamiTF353258.

Enzyme and pathway databases

BRENDAi2.3.1.13. 2681.
ReactomeiR-HSA-177128. Conjugation of salicylate with glycine.
R-HSA-177135. Conjugation of benzoate with glycine.

Miscellaneous databases

ChiTaRSiGLYATL2. human.
GenomeRNAii219970.
PROiQ8WU03.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000156689.
CleanExiHS_GLYATL2.
ExpressionAtlasiQ8WU03. baseline and differential.
GenevisibleiQ8WU03. HS.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR010313. Glycine_N-acyltransferase.
IPR013652. Glycine_N-acyltransferase_C.
IPR015938. Glycine_N-acyltransferase_N.
[Graphical view]
PANTHERiPTHR15298. PTHR15298. 1 hit.
PfamiPF08444. Gly_acyl_tr_C. 1 hit.
PF06021. Gly_acyl_tr_N. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGLYL2_HUMAN
AccessioniPrimary (citable) accession number: Q8WU03
Secondary accession number(s): A5LGC7, Q86WC3, Q96AT2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: March 1, 2002
Last modified: September 7, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.