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Protein
Submitted name:

RYK protein

Gene

RYK

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
RYK proteinImported
Gene namesi
Name:RYKImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei12 – 3524HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34894.

PTM / Processingi

Proteomic databases

PaxDbiQ8WTZ8.

Expressioni

Gene expression databases

BgeeiQ8WTZ8.
GenevisibleiQ8WTZ8. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000296084.

Structurei

3D structure databases

ProteinModelPortaliQ8WTZ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini118 – 391274Protein kinaseInterPro annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG1024. Eukaryota.
ENOG410XSKI. LUCA.
HOGENOMiHOG000236284.
HOVERGENiHBG047417.
KOiK05128.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q8WTZ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
DPVHAAPTTS TRVFYISVGV CCAVIFLVAI ILAVLHLHSM KRIELDDSIS
60 70 80 90 100
ASSSSQGLSQ PSTQTTQYLR ADTPNNATPI TSSLGYPTLR IEKNDLRSVT
110 120 130 140 150
LLEAKGKVKD IAISRERITL KDVLQEGTFG RIFHGILIDE KDPNKEKQAF
160 170 180 190 200
VKTVKDQASE IQVTMMLTES CKLRGLHHRN LLPITHVCIE EGEKPMVILP
210 220 230 240 250
YMNWGNLKLF LRQCKLVEAN NPQAISQQDL VHMAIQIACG MSYLARREVI
260 270 280 290 300
HKDLAARNCV IDDTLQVKIT DNALSRDLFP MDYHCLGDNE NRPVRWMALE
310 320 330 340 350
SLVNNEFSSA SDVWAFGVTL WELMTLGQTP YVDIDPFEMA AYLKDGYRIA
360 370 380 390
QPINCPDELF AVMACCWALD PEERPKFQQL VQCLTEFHAA LGAYV
Length:395
Mass (Da):44,354
Last modified:March 1, 2004 - v2
Checksum:i6A8E7F6B95C6623B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC021700 mRNA. Translation: AAH21700.2.
RefSeqiNP_001005861.1. NM_001005861.2.
NP_002949.2. NM_002958.3.
UniGeneiHs.654562.

Genome annotation databases

GeneIDi6259.
KEGGihsa:6259.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC021700 mRNA. Translation: AAH21700.2.
RefSeqiNP_001005861.1. NM_001005861.2.
NP_002949.2. NM_002958.3.
UniGeneiHs.654562.

3D structure databases

ProteinModelPortaliQ8WTZ8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000296084.

Proteomic databases

PaxDbiQ8WTZ8.

Protocols and materials databases

DNASUi6259.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi6259.
KEGGihsa:6259.

Organism-specific databases

CTDi6259.
PharmGKBiPA34894.

Phylogenomic databases

eggNOGiKOG1024. Eukaryota.
ENOG410XSKI. LUCA.
HOGENOMiHOG000236284.
HOVERGENiHBG047417.
KOiK05128.

Miscellaneous databases

ChiTaRSiRYK. human.
GenomeRNAii6259.

Gene expression databases

BgeeiQ8WTZ8.
GenevisibleiQ8WTZ8. HS.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: KidneyImported.

Entry informationi

Entry nameiQ8WTZ8_HUMAN
AccessioniPrimary (citable) accession number: Q8WTZ8
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2004
Last modified: June 8, 2016
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.