Q8WTZ3 (YS049_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Zinc finger protein ENSP00000375192
Organism	Homo sapiens (Human) [Reference proteome]
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	238 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Nucleus Probable.
Sequence similarities	Contains 1 C2H2-type zinc finger.
Caution	Was initially described as ZNF99.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 238	238	Zinc finger protein ENSP00000375192		PRO_0000277871
Regions
	Zinc finger	27 – 49	23	C2H2-type; degenerate

Sequences

	Sequence		Length	Mass (Da)
	Q8WTZ3 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: FACFD0DB5B6E1C1F	FASTA	238	27,158
	10 20 30 40 50 60 MKNVANTVTI SHILPHIKII HTEEKPDKCE ECNKVFNWSS THTKYKRIHT EDKFYKYEEC 70 80 90 100 110 120 DKSFKNISTL ITHKIIYVVE KFYKCEECGK VFFFFLKWSL TLSPKLECNG AISVHCNLRL 130 140 150 160 170 180 LGSSDSLAST SQAAGIAGAC HHAQLIFVFL VETGFHHFDQ AGFELLTSSD PPALASQSAP 190 200 210 220 230 KCWDYKHEPL SPVECGKVFN KLSNHTGEKL YKPKRHDSAL ENTLNFSKHK RNHSVKKP

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC021822 mRNA. Translation: AAH21822.1.
IPI	IPI00102872.
UniGene	Hs.568380. Hs.737077.
3D structure databases
ProteinModelPortal	Q8WTZ3.
ModBase	Search...
Polymorphism databases
DMDM	74762627.
Proteomic databases
PRIDE	Q8WTZ3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
GeneCards	GC19M022935.
neXtProt	NX_Q8WTZ3.
Phylogenomic databases
OMA	YKRIHTE.
Gene expression databases
Bgee	Q8WTZ3.
Genevestigator	Q8WTZ3.
Family and domain databases
Gene3D	3.30.160.60. 2 hits.
InterPro	IPR007087. Znf_C2H2. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
PROSITE	PS00028. ZINC_FINGER_C2H2_1. False negative. PS50157. ZINC_FINGER_C2H2_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

YS049_HUMAN

Accession

Primary (citable) accession number: Q8WTZ3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 20, 2007
Last sequence update:	March 1, 2002
Last modified:	May 1, 2013
This is version 80 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.