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Protein

Zinc finger protein ENSP00000375192

Gene
N/A
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri27 – 4923C2H2-type; degeneratePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein ENSP00000375192
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 238238Zinc finger protein ENSP00000375192PRO_0000277871Add
BLAST

Proteomic databases

PRIDEiQ8WTZ3.

Expressioni

Gene expression databases

BgeeiQ8WTZ3.
GenevestigatoriQ8WTZ3.

Structurei

3D structure databases

ProteinModelPortaliQ8WTZ3.
SMRiQ8WTZ3. Positions 24-92, 180-238.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 C2H2-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri27 – 4923C2H2-type; degeneratePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

PhylomeDBiQ8WTZ3.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR007087. Znf_C2H2.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PROSITEiPS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WTZ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNVANTVTI SHILPHIKII HTEEKPDKCE ECNKVFNWSS THTKYKRIHT
60 70 80 90 100
EDKFYKYEEC DKSFKNISTL ITHKIIYVVE KFYKCEECGK VFFFFLKWSL
110 120 130 140 150
TLSPKLECNG AISVHCNLRL LGSSDSLAST SQAAGIAGAC HHAQLIFVFL
160 170 180 190 200
VETGFHHFDQ AGFELLTSSD PPALASQSAP KCWDYKHEPL SPVECGKVFN
210 220 230
KLSNHTGEKL YKPKRHDSAL ENTLNFSKHK RNHSVKKP
Length:238
Mass (Da):27,158
Last modified:March 1, 2002 - v1
Checksum:iFACFD0DB5B6E1C1F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC021822 mRNA. Translation: AAH21822.1.
UniGeneiHs.568380.
Hs.737077.

Polymorphism databases

DMDMi74762627.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC021822 mRNA. Translation: AAH21822.1.
UniGeneiHs.568380.
Hs.737077.

3D structure databases

ProteinModelPortaliQ8WTZ3.
SMRiQ8WTZ3. Positions 24-92, 180-238.
ModBaseiSearch...
MobiDBiSearch...

Polymorphism databases

DMDMi74762627.

Proteomic databases

PRIDEiQ8WTZ3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

neXtProtiNX_Q8WTZ3.

Phylogenomic databases

PhylomeDBiQ8WTZ3.

Gene expression databases

BgeeiQ8WTZ3.
GenevestigatoriQ8WTZ3.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR007087. Znf_C2H2.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PROSITEiPS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiYS049_HUMAN
AccessioniPrimary (citable) accession number: Q8WTZ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: March 1, 2002
Last modified: January 7, 2015
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Was initially described as ZNF99.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.