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Protein

Probable palmitoyltransferase ZDHHC1

Gene

ZDHHC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

GO - Molecular functioni

  • DNA binding Source: UniProtKB
  • palmitoyltransferase activity Source: UniProtKB
  • protein-cysteine S-palmitoyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  • protein palmitoylation Source: UniProtKB

Keywordsi

Molecular functionAcyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable palmitoyltransferase ZDHHC1 (EC:2.3.1.225)
Alternative name(s):
DHHC domain-containing cysteine-rich protein 1
Zinc finger DHHC domain-containing protein 1
Short name:
DHHC-1
Zinc finger protein 377
Gene namesi
Name:ZDHHC1
Synonyms:C16orf1, ZNF377
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:17916. ZDHHC1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei53 – 73HelicalSequence analysisAdd BLAST21
Transmembranei78 – 98HelicalSequence analysisAdd BLAST21
Transmembranei186 – 206HelicalSequence analysisAdd BLAST21
Transmembranei242 – 262HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • endoplasmic reticulum Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi29800.
OpenTargetsiENSG00000159714.
PharmGKBiPA38261.

Polymorphism and mutation databases

BioMutaiZDHHC1.
DMDMi28202100.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002128571 – 485Probable palmitoyltransferase ZDHHC1Add BLAST485

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ8WTX9.
PeptideAtlasiQ8WTX9.
PRIDEiQ8WTX9.

PTM databases

iPTMnetiQ8WTX9.
PhosphoSitePlusiQ8WTX9.

Expressioni

Tissue specificityi

Expressed at high levels in fetal lung, kidney and heart. Expressed at lower levels in adult pancreas and lung.1 Publication

Gene expression databases

BgeeiENSG00000159714.
CleanExiHS_ZDHHC1.
ExpressionAtlasiQ8WTX9. baseline and differential.
GenevisibleiQ8WTX9. HS.

Organism-specific databases

HPAiHPA042531.
HPA048659.

Interactioni

Protein-protein interaction databases

BioGridi118924. 6 interactors.
IntActiQ8WTX9. 15 interactors.
STRINGi9606.ENSP00000340299.

Structurei

3D structure databases

ProteinModelPortaliQ8WTX9.
SMRiQ8WTX9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini134 – 184DHHCPROSITE-ProRule annotationAdd BLAST51

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1311. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00870000136460.
HOGENOMiHOG000120122.
HOVERGENiHBG059666.
InParanoidiQ8WTX9.
KOiK20027.
OMAiQEAKGAH.
OrthoDBiEOG091G0A1N.
PhylomeDBiQ8WTX9.
TreeFamiTF317498.

Family and domain databases

InterProiView protein in InterPro
IPR001594. Palmitoyltrfase_DHHC.
PfamiView protein in Pfam
PF01529. zf-DHHC. 1 hit.
PROSITEiView protein in PROSITE
PS50216. DHHC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8WTX9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYKMNICNKP SNKTAPEKSV WTAPAQPSGP SPELQGQRSR RNGWSWPPHP
60 70 80 90 100
LQIVAWLLYL FFAVIGFGIL VPLLPHHWVP AGYACMGAIF AGHLVVHLTA
110 120 130 140 150
VSIDPADANV RDKSYAGPLP IFNRSQHAHV IEDLHCNLCN VDVSARSKHC
160 170 180 190 200
SACNKCVCGF DHHCKWLNNC VGERNYRLFL HSVASALLGV LLLVLVATYV
210 220 230 240 250
FVEFFVNPMR LRTNRHFEVL KNHTDVWFVF LPAAPVETQA PAILALAALL
260 270 280 290 300
ILLGLLSTAL LGHLLCFHIY LMWHKLTTYE YIVQHRPPQE AKGVHRELES
310 320 330 340 350
CPPKMRPIQE MEFYMRTFRH MRPEPPGQAG PAAVNAKHSR PASPDPTPGR
360 370 380 390 400
RDCAGPPVQV EWDRKKPLPW RSPLLLLAMW GPQAPPCLCR KRGRGACIKC
410 420 430 440 450
ERLRPRIRRR GLGPPAAAPA RRRIPRTPAL CTPLALPAPT TRRRQSPWTR
460 470 480
FQWRRRAWAA PLWPPRGAGA DSPRWRGRRV RPPFS
Length:485
Mass (Da):54,818
Last modified:March 1, 2002 - v1
Checksum:i6B75B077D782F358
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052972124R → Q. Corresponds to variant dbSNP:rs34229857Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC021908 mRNA. Translation: AAH21908.1.
U90653 mRNA. Translation: AAB86591.2.
CCDSiCCDS10836.1.
RefSeqiNP_001310556.1. NM_001323627.1.
NP_037436.1. NM_013304.2.
UniGeneiHs.624541.
Hs.658333.

Genome annotation databases

EnsembliENST00000348579; ENSP00000340299; ENSG00000159714.
GeneIDi29800.
KEGGihsa:29800.
UCSCiuc010vjm.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC021908 mRNA. Translation: AAH21908.1.
U90653 mRNA. Translation: AAB86591.2.
CCDSiCCDS10836.1.
RefSeqiNP_001310556.1. NM_001323627.1.
NP_037436.1. NM_013304.2.
UniGeneiHs.624541.
Hs.658333.

3D structure databases

ProteinModelPortaliQ8WTX9.
SMRiQ8WTX9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118924. 6 interactors.
IntActiQ8WTX9. 15 interactors.
STRINGi9606.ENSP00000340299.

PTM databases

iPTMnetiQ8WTX9.
PhosphoSitePlusiQ8WTX9.

Polymorphism and mutation databases

BioMutaiZDHHC1.
DMDMi28202100.

Proteomic databases

PaxDbiQ8WTX9.
PeptideAtlasiQ8WTX9.
PRIDEiQ8WTX9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000348579; ENSP00000340299; ENSG00000159714.
GeneIDi29800.
KEGGihsa:29800.
UCSCiuc010vjm.3. human.

Organism-specific databases

CTDi29800.
DisGeNETi29800.
GeneCardsiZDHHC1.
HGNCiHGNC:17916. ZDHHC1.
HPAiHPA042531.
HPA048659.
neXtProtiNX_Q8WTX9.
OpenTargetsiENSG00000159714.
PharmGKBiPA38261.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1311. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00870000136460.
HOGENOMiHOG000120122.
HOVERGENiHBG059666.
InParanoidiQ8WTX9.
KOiK20027.
OMAiQEAKGAH.
OrthoDBiEOG091G0A1N.
PhylomeDBiQ8WTX9.
TreeFamiTF317498.

Miscellaneous databases

GenomeRNAii29800.
PROiPR:Q8WTX9.

Gene expression databases

BgeeiENSG00000159714.
CleanExiHS_ZDHHC1.
ExpressionAtlasiQ8WTX9. baseline and differential.
GenevisibleiQ8WTX9. HS.

Family and domain databases

InterProiView protein in InterPro
IPR001594. Palmitoyltrfase_DHHC.
PfamiView protein in Pfam
PF01529. zf-DHHC. 1 hit.
PROSITEiView protein in PROSITE
PS50216. DHHC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiZDHC1_HUMAN
AccessioniPrimary (citable) accession number: Q8WTX9
Secondary accession number(s): O15461
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: March 1, 2002
Last modified: March 15, 2017
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.