ID THAP3_HUMAN Reviewed; 239 AA. AC Q8WTV1; Q569K1; Q5TH66; Q5TH67; Q8N8T6; Q9BSC7; Q9Y3H2; Q9Y3H3; DT 11-APR-2003, integrated into UniProtKB/Swiss-Prot. DT 01-MAR-2002, sequence version 1. DT 24-JAN-2024, entry version 167. DE RecName: Full=THAP domain-containing protein 3; GN Name=THAP3; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). RC TISSUE=Teratocarcinoma; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., RA Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16710414; DOI=10.1038/nature04727; RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K., RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.; RT "The DNA sequence and biological annotation of human chromosome 1."; RL Nature 441:315-321(2006). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND NUCLEOTIDE SEQUENCE RP [LARGE SCALE MRNA] OF 93-239 (ISOFORMS 1/2). RC TISSUE=Brain, and Uterus; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [4] RP INTERACTION WITH HCFC1 AND OGT, TISSUE SPECIFICITY, IDENTIFICATION BY MASS RP SPECTROMETRY, FUNCTION, AND MUTAGENESIS OF 177-ASP--TYR-180. RX PubMed=20200153; DOI=10.1074/jbc.m109.072579; RA Mazars R., Gonzalez-de-Peredo A., Cayrol C., Lavigne A.C., Vogel J.L., RA Ortega N., Lacroix C., Gautier V., Huet G., Ray A., Monsarrat B., RA Kristie T.M., Girard J.P.; RT "The THAP-zinc finger protein THAP1 associates with coactivator HCF-1 and RT O-GlcNAc transferase: a link between DYT6 and DYT3 dystonias."; RL J. Biol. Chem. 285:13364-13371(2010). RN [5] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-122, AND IDENTIFICATION BY RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma, and Erythroleukemia; RX PubMed=23186163; DOI=10.1021/pr300630k; RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., RA Mohammed S.; RT "Toward a comprehensive characterization of a human cancer cell RT phosphoproteome."; RL J. Proteome Res. 12:260-271(2013). CC -!- FUNCTION: Component of a THAP1/THAP3-HCFC1-OGT complex that is required CC for the regulation of the transcriptional activity of RRM1. CC {ECO:0000269|PubMed:20200153}. CC -!- SUBUNIT: Component of a THAP1/THAP3-HCFC1-OGT complex that contains at CC least, either THAP1 or THAP3, HCFC1 and OGT. Interacts directly with CC OGT and HCFC1 (via its HBM). {ECO:0000269|PubMed:20200153}. CC -!- INTERACTION: CC Q8WTV1; P46379-2: BAG6; NbExp=3; IntAct=EBI-17438286, EBI-10988864; CC Q8WTV1; P28329-3: CHAT; NbExp=3; IntAct=EBI-17438286, EBI-25837549; CC Q8WTV1; O75190-2: DNAJB6; NbExp=3; IntAct=EBI-17438286, EBI-12593112; CC Q8WTV1; O14645: DNALI1; NbExp=3; IntAct=EBI-17438286, EBI-395638; CC Q8WTV1; P15311: EZR; NbExp=3; IntAct=EBI-17438286, EBI-1056902; CC Q8WTV1; P22607: FGFR3; NbExp=3; IntAct=EBI-17438286, EBI-348399; CC Q8WTV1; Q14957: GRIN2C; NbExp=3; IntAct=EBI-17438286, EBI-8285963; CC Q8WTV1; O14901: KLF11; NbExp=3; IntAct=EBI-17438286, EBI-948266; CC Q8WTV1; Q13449: LSAMP; NbExp=3; IntAct=EBI-17438286, EBI-4314821; CC Q8WTV1; P28331-2: NDUFS1; NbExp=3; IntAct=EBI-17438286, EBI-6190702; CC Q8WTV1; P61970: NUTF2; NbExp=3; IntAct=EBI-17438286, EBI-591778; CC Q8WTV1; Q16512: PKN1; NbExp=3; IntAct=EBI-17438286, EBI-602382; CC Q8WTV1; P24928: POLR2A; NbExp=3; IntAct=EBI-17438286, EBI-295301; CC Q8WTV1; P63000: RAC1; NbExp=3; IntAct=EBI-17438286, EBI-413628; CC Q8WTV1; P14678-2: SNRPB; NbExp=3; IntAct=EBI-17438286, EBI-372475; CC Q8WTV1; Q13148: TARDBP; NbExp=6; IntAct=EBI-17438286, EBI-372899; CC Q8WTV1; P14679-2: TYR; NbExp=3; IntAct=EBI-17438286, EBI-25894402; CC Q8WTV1; Q9BZL1: UBL5; NbExp=3; IntAct=EBI-17438286, EBI-607755; CC Q8WTV1; Q9UMX0: UBQLN1; NbExp=3; IntAct=EBI-17438286, EBI-741480; CC Q8WTV1; P14927: UQCRB; NbExp=3; IntAct=EBI-17438286, EBI-743128; CC Q8WTV1; P31930: UQCRC1; NbExp=3; IntAct=EBI-17438286, EBI-1052596; CC Q8WTV1; P61758: VBP1; NbExp=3; IntAct=EBI-17438286, EBI-357430; CC Q8WTV1; Q9Y649; NbExp=3; IntAct=EBI-17438286, EBI-25900580; CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=3; CC Name=1; CC IsoId=Q8WTV1-1; Sequence=Displayed; CC Name=2; CC IsoId=Q8WTV1-3; Sequence=VSP_015136; CC Name=3; CC IsoId=Q8WTV1-4; Sequence=VSP_015137, VSP_015138, VSP_015139; CC -!- TISSUE SPECIFICITY: Highly expressed in heart, skeletal muscle and CC placenta. Weaker expression in brain, kidney and liver. CC {ECO:0000269|PubMed:20200153}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK096217; BAC04727.1; -; mRNA. DR EMBL; AL031447; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC005114; AAH05114.1; -; mRNA. DR EMBL; BC092427; AAH92427.1; -; mRNA. DR CCDS; CCDS55572.1; -. [Q8WTV1-1] DR CCDS; CCDS55573.1; -. [Q8WTV1-3] DR CCDS; CCDS86.1; -. [Q8WTV1-4] DR RefSeq; NP_001182681.1; NM_001195752.1. [Q8WTV1-3] DR RefSeq; NP_001182682.1; NM_001195753.1. [Q8WTV1-1] DR RefSeq; NP_612359.2; NM_138350.3. [Q8WTV1-4] DR RefSeq; XP_005263589.1; XM_005263532.3. DR AlphaFoldDB; Q8WTV1; -. DR SMR; Q8WTV1; -. DR BioGRID; 124694; 81. DR ELM; Q8WTV1; -. DR IntAct; Q8WTV1; 24. DR STRING; 9606.ENSP00000054650; -. DR GlyGen; Q8WTV1; 1 site, 1 O-linked glycan (1 site). DR iPTMnet; Q8WTV1; -. DR PhosphoSitePlus; Q8WTV1; -. DR BioMuta; THAP3; -. DR DMDM; 29839586; -. DR EPD; Q8WTV1; -. DR jPOST; Q8WTV1; -. DR MassIVE; Q8WTV1; -. DR MaxQB; Q8WTV1; -. DR PaxDb; 9606-ENSP00000054650; -. DR PeptideAtlas; Q8WTV1; -. DR ProteomicsDB; 74606; -. [Q8WTV1-1] DR ProteomicsDB; 74607; -. [Q8WTV1-3] DR Pumba; Q8WTV1; -. DR Antibodypedia; 27449; 69 antibodies from 18 providers. DR DNASU; 90326; -. DR Ensembl; ENST00000054650.9; ENSP00000054650.4; ENSG00000041988.16. [Q8WTV1-1] DR Ensembl; ENST00000307896.10; ENSP00000311537.6; ENSG00000041988.16. [Q8WTV1-3] DR Ensembl; ENST00000377627.7; ENSP00000366854.3; ENSG00000041988.16. [Q8WTV1-4] DR GeneID; 90326; -. DR KEGG; hsa:90326; -. DR MANE-Select; ENST00000054650.9; ENSP00000054650.4; NM_001195753.2; NP_001182682.1. DR UCSC; uc001aoc.4; human. [Q8WTV1-1] DR AGR; HGNC:20855; -. DR CTD; 90326; -. DR DisGeNET; 90326; -. DR GeneCards; THAP3; -. DR HGNC; HGNC:20855; THAP3. DR HPA; ENSG00000041988; Low tissue specificity. DR MIM; 612532; gene. DR neXtProt; NX_Q8WTV1; -. DR OpenTargets; ENSG00000041988; -. DR PharmGKB; PA134987111; -. DR VEuPathDB; HostDB:ENSG00000041988; -. DR eggNOG; ENOG502S14P; Eukaryota. DR GeneTree; ENSGT00940000162344; -. DR HOGENOM; CLU_076186_1_0_1; -. DR InParanoid; Q8WTV1; -. DR OMA; ACKGHWG; -. DR OrthoDB; 5356539at2759; -. DR PhylomeDB; Q8WTV1; -. DR TreeFam; TF330127; -. DR PathwayCommons; Q8WTV1; -. DR SignaLink; Q8WTV1; -. DR BioGRID-ORCS; 90326; 22 hits in 1176 CRISPR screens. DR ChiTaRS; THAP3; human. DR GenomeRNAi; 90326; -. DR Pharos; Q8WTV1; Tdark. DR PRO; PR:Q8WTV1; -. DR Proteomes; UP000005640; Chromosome 1. DR RNAct; Q8WTV1; Protein. DR Bgee; ENSG00000041988; Expressed in apex of heart and 103 other cell types or tissues. DR ExpressionAtlas; Q8WTV1; baseline and differential. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:ARUK-UCL. DR InterPro; IPR026520; THAP3. DR InterPro; IPR006612; THAP_Znf. DR PANTHER; PTHR47120; THAP DOMAIN-CONTAINING PROTEIN 3; 1. DR PANTHER; PTHR47120:SF1; THAP DOMAIN-CONTAINING PROTEIN 3; 1. DR Pfam; PF05485; THAP; 1. DR SMART; SM00692; DM3; 1. DR SMART; SM00980; THAP; 1. DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1. DR PROSITE; PS50950; ZF_THAP; 1. DR Genevisible; Q8WTV1; HS. PE 1: Evidence at protein level; KW Alternative splicing; DNA-binding; Metal-binding; Phosphoprotein; KW Reference proteome; Zinc; Zinc-finger. FT CHAIN 1..239 FT /note="THAP domain-containing protein 3" FT /id="PRO_0000068644" FT ZN_FING 1..82 FT /note="THAP-type" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00309" FT REGION 84..177 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT MOTIF 177..180 FT /note="HCFC1-binding motif (HBM)" FT COMPBIAS 84..110 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT MOD_RES 122 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:23186163" FT VAR_SEQ 89 FT /note="Missing (in isoform 2)" FT /evidence="ECO:0000305" FT /id="VSP_015136" FT VAR_SEQ 111 FT /note="K -> KTSPCRSQ (in isoform 3)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_015137" FT VAR_SEQ 147..168 FT /note="VSPRRPQATEAVGRPTGPAGLR -> AMLFNVENGTPASREALWLSEE (in FT isoform 3)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_015138" FT VAR_SEQ 169..239 FT /note="Missing (in isoform 3)" FT /evidence="ECO:0000303|PubMed:14702039" FT /id="VSP_015139" FT MUTAGEN 177..180 FT /note="DHSY->AAAA: Abolishes interaction with HCFC1." FT /evidence="ECO:0000269|PubMed:20200153" FT MUTAGEN 178 FT /note="H->A: Abolishes interaction with HCFC1." FT MUTAGEN 180 FT /note="Y->A: Abolishes interaction with HCFC1." FT CONFLICT 227 FT /note="Q -> R (in Ref. 3; AAH05114/AAH92427)" FT /evidence="ECO:0000305" SQ SEQUENCE 239 AA; 27059 MW; 9904C925DF233397 CRC64; MPKSCAARQC CNRYSSRRKQ LTFHRFPFSR PELLKEWVLN IGRGNFKPKQ HTVICSEHFR PECFSAFGNR KNLKHNAVPT VFAFQDPTQQ VRENTDPASE RGNASSSQKE KVLPEAGAGE DSPGRNMDTA LEELQLPPNA EGHVKQVSPR RPQATEAVGR PTGPAGLRRT PNKQPSDHSY ALLDLDSLKK KLFLTLKENE KLRKRLQAQR LVMRRMSSRL RACKGHQGLQ ARLGPEQQS //