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Q8WTV1

- THAP3_HUMAN

UniProt

Q8WTV1 - THAP3_HUMAN

Protein

THAP domain-containing protein 3

Gene

THAP3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri1 – 8282THAP-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. protein binding Source: UniProtKB

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    THAP domain-containing protein 3
    Gene namesi
    Name:THAP3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:20855. THAP3.

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi177 – 1804DHSY → AAAA: Abolishes interaction with HCFC1. 1 Publication
    Mutagenesisi178 – 1781H → A: Abolishes interaction with HCFC1. 1 Publication
    Mutagenesisi180 – 1801Y → A: Abolishes interaction with HCFC1. 1 Publication

    Organism-specific databases

    PharmGKBiPA134987111.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 239239THAP domain-containing protein 3PRO_0000068644Add
    BLAST

    Proteomic databases

    PaxDbiQ8WTV1.
    PRIDEiQ8WTV1.

    PTM databases

    PhosphoSiteiQ8WTV1.

    Expressioni

    Tissue specificityi

    Highly expressed in heart, skeletal muscle and placenta. Weaker expression in brain, kidney and liver.1 Publication

    Gene expression databases

    ArrayExpressiQ8WTV1.
    BgeeiQ8WTV1.
    CleanExiHS_THAP3.
    GenevestigatoriQ8WTV1.

    Organism-specific databases

    HPAiHPA044460.

    Interactioni

    Subunit structurei

    Component of a THAP1/THAP3-HCFC1-OGT complex that contains at least, either THAP1 or THAP3, HCFC1 and OGT. Interacts directly with OGT and HCFC1 (via its HBM).1 Publication

    Protein-protein interaction databases

    BioGridi124694. 4 interactions.
    STRINGi9606.ENSP00000366854.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8WTV1.
    SMRiQ8WTV1. Positions 1-82.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi177 – 1804HCFC1-binding motif (HBM)

    Sequence similaritiesi

    Contains 1 THAP-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri1 – 8282THAP-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG79389.
    HOVERGENiHBG100591.
    InParanoidiQ8WTV1.
    OMAiKAQRLVM.
    OrthoDBiEOG7QVM4D.
    PhylomeDBiQ8WTV1.
    TreeFamiTF330127.

    Family and domain databases

    InterProiIPR026520. THAP3.
    IPR006612. Znf_C2CH.
    [Graphical view]
    PANTHERiPTHR23080:SF46. PTHR23080:SF46. 1 hit.
    PfamiPF05485. THAP. 1 hit.
    [Graphical view]
    SMARTiSM00692. DM3. 1 hit.
    SM00980. THAP. 1 hit.
    [Graphical view]
    PROSITEiPS50950. ZF_THAP. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8WTV1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPKSCAARQC CNRYSSRRKQ LTFHRFPFSR PELLKEWVLN IGRGNFKPKQ    50
    HTVICSEHFR PECFSAFGNR KNLKHNAVPT VFAFQDPTQQ VRENTDPASE 100
    RGNASSSQKE KVLPEAGAGE DSPGRNMDTA LEELQLPPNA EGHVKQVSPR 150
    RPQATEAVGR PTGPAGLRRT PNKQPSDHSY ALLDLDSLKK KLFLTLKENE 200
    KLRKRLQAQR LVMRRMSSRL RACKGHQGLQ ARLGPEQQS 239
    Length:239
    Mass (Da):27,059
    Last modified:March 1, 2002 - v1
    Checksum:i9904C925DF233397
    GO
    Isoform 2 (identifier: Q8WTV1-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         89-89: Missing.

    Note: Gene prediction based on EST data.

    Show »
    Length:238
    Mass (Da):26,931
    Checksum:i54667E778F734995
    GO
    Isoform 3 (identifier: Q8WTV1-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         111-111: K → KTSPCRSQ
         147-168: VSPRRPQATEAVGRPTGPAGLR → AMLFNVENGTPASREALWLSEE
         169-239: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:175
    Mass (Da):19,729
    Checksum:iB6B9A4540DC5A8B4
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti227 – 2271Q → R in AAH05114. (PubMed:15489334)Curated
    Sequence conflicti227 – 2271Q → R in AAH92427. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei89 – 891Missing in isoform 2. CuratedVSP_015136
    Alternative sequencei111 – 1111K → KTSPCRSQ in isoform 3. 1 PublicationVSP_015137
    Alternative sequencei147 – 16822VSPRR…PAGLR → AMLFNVENGTPASREALWLS EE in isoform 3. 1 PublicationVSP_015138Add
    BLAST
    Alternative sequencei169 – 23971Missing in isoform 3. 1 PublicationVSP_015139Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK096217 mRNA. Translation: BAC04727.1.
    AL031447 Genomic DNA. Translation: CAI19468.1.
    AL031447 Genomic DNA. Translation: CAI19469.1.
    AL031447 Genomic DNA. Translation: CAI19470.1.
    BC005114 mRNA. Translation: AAH05114.1.
    BC092427 mRNA. Translation: AAH92427.1.
    CCDSiCCDS55572.1. [Q8WTV1-1]
    CCDS55573.1. [Q8WTV1-3]
    CCDS86.1. [Q8WTV1-4]
    RefSeqiNP_001182681.1. NM_001195752.1. [Q8WTV1-3]
    NP_001182682.1. NM_001195753.1. [Q8WTV1-1]
    NP_612359.2. NM_138350.3. [Q8WTV1-4]
    XP_005263589.1. XM_005263532.1. [Q8WTV1-3]
    UniGeneiHs.689006.

    Genome annotation databases

    EnsembliENST00000054650; ENSP00000054650; ENSG00000041988. [Q8WTV1-1]
    ENST00000307896; ENSP00000311537; ENSG00000041988. [Q8WTV1-3]
    ENST00000377627; ENSP00000366854; ENSG00000041988. [Q8WTV1-4]
    GeneIDi90326.
    KEGGihsa:90326.
    UCSCiuc001aoc.3. human. [Q8WTV1-1]
    uc001aod.3. human. [Q8WTV1-3]
    uc001aoe.2. human. [Q8WTV1-4]

    Polymorphism databases

    DMDMi29839586.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK096217 mRNA. Translation: BAC04727.1 .
    AL031447 Genomic DNA. Translation: CAI19468.1 .
    AL031447 Genomic DNA. Translation: CAI19469.1 .
    AL031447 Genomic DNA. Translation: CAI19470.1 .
    BC005114 mRNA. Translation: AAH05114.1 .
    BC092427 mRNA. Translation: AAH92427.1 .
    CCDSi CCDS55572.1. [Q8WTV1-1 ]
    CCDS55573.1. [Q8WTV1-3 ]
    CCDS86.1. [Q8WTV1-4 ]
    RefSeqi NP_001182681.1. NM_001195752.1. [Q8WTV1-3 ]
    NP_001182682.1. NM_001195753.1. [Q8WTV1-1 ]
    NP_612359.2. NM_138350.3. [Q8WTV1-4 ]
    XP_005263589.1. XM_005263532.1. [Q8WTV1-3 ]
    UniGenei Hs.689006.

    3D structure databases

    ProteinModelPortali Q8WTV1.
    SMRi Q8WTV1. Positions 1-82.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124694. 4 interactions.
    STRINGi 9606.ENSP00000366854.

    PTM databases

    PhosphoSitei Q8WTV1.

    Polymorphism databases

    DMDMi 29839586.

    Proteomic databases

    PaxDbi Q8WTV1.
    PRIDEi Q8WTV1.

    Protocols and materials databases

    DNASUi 90326.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000054650 ; ENSP00000054650 ; ENSG00000041988 . [Q8WTV1-1 ]
    ENST00000307896 ; ENSP00000311537 ; ENSG00000041988 . [Q8WTV1-3 ]
    ENST00000377627 ; ENSP00000366854 ; ENSG00000041988 . [Q8WTV1-4 ]
    GeneIDi 90326.
    KEGGi hsa:90326.
    UCSCi uc001aoc.3. human. [Q8WTV1-1 ]
    uc001aod.3. human. [Q8WTV1-3 ]
    uc001aoe.2. human. [Q8WTV1-4 ]

    Organism-specific databases

    CTDi 90326.
    GeneCardsi GC01P006684.
    HGNCi HGNC:20855. THAP3.
    HPAi HPA044460.
    MIMi 612532. gene.
    neXtProti NX_Q8WTV1.
    PharmGKBi PA134987111.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG79389.
    HOVERGENi HBG100591.
    InParanoidi Q8WTV1.
    OMAi KAQRLVM.
    OrthoDBi EOG7QVM4D.
    PhylomeDBi Q8WTV1.
    TreeFami TF330127.

    Miscellaneous databases

    ChiTaRSi THAP3. human.
    GenomeRNAii 90326.
    NextBioi 76664.
    PROi Q8WTV1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8WTV1.
    Bgeei Q8WTV1.
    CleanExi HS_THAP3.
    Genevestigatori Q8WTV1.

    Family and domain databases

    InterProi IPR026520. THAP3.
    IPR006612. Znf_C2CH.
    [Graphical view ]
    PANTHERi PTHR23080:SF46. PTHR23080:SF46. 1 hit.
    Pfami PF05485. THAP. 1 hit.
    [Graphical view ]
    SMARTi SM00692. DM3. 1 hit.
    SM00980. THAP. 1 hit.
    [Graphical view ]
    PROSITEi PS50950. ZF_THAP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Teratocarcinoma.
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 93-239 (ISOFORMS 1/2).
      Tissue: Brain and Uterus.
    4. "The THAP-zinc finger protein THAP1 associates with coactivator HCF-1 and O-GlcNAc transferase: a link between DYT6 and DYT3 dystonias."
      Mazars R., Gonzalez-de-Peredo A., Cayrol C., Lavigne A.C., Vogel J.L., Ortega N., Lacroix C., Gautier V., Huet G., Ray A., Monsarrat B., Kristie T.M., Girard J.P.
      J. Biol. Chem. 285:13364-13371(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH HCFC1 AND OGT, TISSUE SPECIFICITY, IDENTIFICATION BY MASS SPECTROMETRY, FUNCTION, MUTAGENESIS OF 177-ASP--TYR-180.

    Entry informationi

    Entry nameiTHAP3_HUMAN
    AccessioniPrimary (citable) accession number: Q8WTV1
    Secondary accession number(s): Q569K1
    , Q5TH66, Q5TH67, Q8N8T6, Q9BSC7, Q9Y3H2, Q9Y3H3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 11, 2003
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3