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Q8WTV1

- THAP3_HUMAN

UniProt

Q8WTV1 - THAP3_HUMAN

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Protein

THAP domain-containing protein 3

Gene

THAP3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1 – 8282THAP-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
THAP domain-containing protein 3
Gene namesi
Name:THAP3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:20855. THAP3.

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi177 – 1804DHSY → AAAA: Abolishes interaction with HCFC1. 1 Publication
Mutagenesisi178 – 1781H → A: Abolishes interaction with HCFC1.
Mutagenesisi180 – 1801Y → A: Abolishes interaction with HCFC1.

Organism-specific databases

PharmGKBiPA134987111.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 239239THAP domain-containing protein 3PRO_0000068644Add
BLAST

Proteomic databases

MaxQBiQ8WTV1.
PaxDbiQ8WTV1.
PRIDEiQ8WTV1.

PTM databases

PhosphoSiteiQ8WTV1.

Expressioni

Tissue specificityi

Highly expressed in heart, skeletal muscle and placenta. Weaker expression in brain, kidney and liver.1 Publication

Gene expression databases

BgeeiQ8WTV1.
CleanExiHS_THAP3.
ExpressionAtlasiQ8WTV1. baseline and differential.
GenevestigatoriQ8WTV1.

Organism-specific databases

HPAiHPA044460.

Interactioni

Subunit structurei

Component of a THAP1/THAP3-HCFC1-OGT complex that contains at least, either THAP1 or THAP3, HCFC1 and OGT. Interacts directly with OGT and HCFC1 (via its HBM).1 Publication

Protein-protein interaction databases

BioGridi124694. 5 interactions.
STRINGi9606.ENSP00000366854.

Structurei

3D structure databases

ProteinModelPortaliQ8WTV1.
SMRiQ8WTV1. Positions 1-82.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi177 – 1804HCFC1-binding motif (HBM)

Sequence similaritiesi

Contains 1 THAP-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri1 – 8282THAP-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG79389.
GeneTreeiENSGT00530000063253.
HOVERGENiHBG100591.
InParanoidiQ8WTV1.
OMAiKAQRLVM.
OrthoDBiEOG7QVM4D.
PhylomeDBiQ8WTV1.
TreeFamiTF330127.

Family and domain databases

InterProiIPR026520. THAP3.
IPR006612. Znf_C2CH.
[Graphical view]
PANTHERiPTHR23080:SF46. PTHR23080:SF46. 1 hit.
PfamiPF05485. THAP. 1 hit.
[Graphical view]
SMARTiSM00692. DM3. 1 hit.
SM00980. THAP. 1 hit.
[Graphical view]
PROSITEiPS50950. ZF_THAP. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8WTV1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPKSCAARQC CNRYSSRRKQ LTFHRFPFSR PELLKEWVLN IGRGNFKPKQ
60 70 80 90 100
HTVICSEHFR PECFSAFGNR KNLKHNAVPT VFAFQDPTQQ VRENTDPASE
110 120 130 140 150
RGNASSSQKE KVLPEAGAGE DSPGRNMDTA LEELQLPPNA EGHVKQVSPR
160 170 180 190 200
RPQATEAVGR PTGPAGLRRT PNKQPSDHSY ALLDLDSLKK KLFLTLKENE
210 220 230
KLRKRLQAQR LVMRRMSSRL RACKGHQGLQ ARLGPEQQS
Length:239
Mass (Da):27,059
Last modified:March 1, 2002 - v1
Checksum:i9904C925DF233397
GO
Isoform 2 (identifier: Q8WTV1-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     89-89: Missing.

Note: Gene prediction based on EST data.

Show »
Length:238
Mass (Da):26,931
Checksum:i54667E778F734995
GO
Isoform 3 (identifier: Q8WTV1-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     111-111: K → KTSPCRSQ
     147-168: VSPRRPQATEAVGRPTGPAGLR → AMLFNVENGTPASREALWLSEE
     169-239: Missing.

Note: No experimental confirmation available.

Show »
Length:175
Mass (Da):19,729
Checksum:iB6B9A4540DC5A8B4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti227 – 2271Q → R in AAH05114. (PubMed:15489334)Curated
Sequence conflicti227 – 2271Q → R in AAH92427. (PubMed:15489334)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei89 – 891Missing in isoform 2. CuratedVSP_015136
Alternative sequencei111 – 1111K → KTSPCRSQ in isoform 3. 1 PublicationVSP_015137
Alternative sequencei147 – 16822VSPRR…PAGLR → AMLFNVENGTPASREALWLS EE in isoform 3. 1 PublicationVSP_015138Add
BLAST
Alternative sequencei169 – 23971Missing in isoform 3. 1 PublicationVSP_015139Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK096217 mRNA. Translation: BAC04727.1.
AL031447 Genomic DNA. Translation: CAI19468.1.
AL031447 Genomic DNA. Translation: CAI19469.1.
AL031447 Genomic DNA. Translation: CAI19470.1.
BC005114 mRNA. Translation: AAH05114.1.
BC092427 mRNA. Translation: AAH92427.1.
CCDSiCCDS55572.1. [Q8WTV1-1]
CCDS55573.1. [Q8WTV1-3]
CCDS86.1. [Q8WTV1-4]
RefSeqiNP_001182681.1. NM_001195752.1. [Q8WTV1-3]
NP_001182682.1. NM_001195753.1. [Q8WTV1-1]
NP_612359.2. NM_138350.3. [Q8WTV1-4]
XP_005263589.1. XM_005263532.1. [Q8WTV1-3]
UniGeneiHs.689006.

Genome annotation databases

EnsembliENST00000054650; ENSP00000054650; ENSG00000041988. [Q8WTV1-1]
ENST00000307896; ENSP00000311537; ENSG00000041988. [Q8WTV1-3]
ENST00000377627; ENSP00000366854; ENSG00000041988. [Q8WTV1-4]
GeneIDi90326.
KEGGihsa:90326.
UCSCiuc001aoc.3. human. [Q8WTV1-1]
uc001aod.3. human. [Q8WTV1-3]
uc001aoe.2. human. [Q8WTV1-4]

Polymorphism databases

DMDMi29839586.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK096217 mRNA. Translation: BAC04727.1 .
AL031447 Genomic DNA. Translation: CAI19468.1 .
AL031447 Genomic DNA. Translation: CAI19469.1 .
AL031447 Genomic DNA. Translation: CAI19470.1 .
BC005114 mRNA. Translation: AAH05114.1 .
BC092427 mRNA. Translation: AAH92427.1 .
CCDSi CCDS55572.1. [Q8WTV1-1 ]
CCDS55573.1. [Q8WTV1-3 ]
CCDS86.1. [Q8WTV1-4 ]
RefSeqi NP_001182681.1. NM_001195752.1. [Q8WTV1-3 ]
NP_001182682.1. NM_001195753.1. [Q8WTV1-1 ]
NP_612359.2. NM_138350.3. [Q8WTV1-4 ]
XP_005263589.1. XM_005263532.1. [Q8WTV1-3 ]
UniGenei Hs.689006.

3D structure databases

ProteinModelPortali Q8WTV1.
SMRi Q8WTV1. Positions 1-82.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124694. 5 interactions.
STRINGi 9606.ENSP00000366854.

PTM databases

PhosphoSitei Q8WTV1.

Polymorphism databases

DMDMi 29839586.

Proteomic databases

MaxQBi Q8WTV1.
PaxDbi Q8WTV1.
PRIDEi Q8WTV1.

Protocols and materials databases

DNASUi 90326.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000054650 ; ENSP00000054650 ; ENSG00000041988 . [Q8WTV1-1 ]
ENST00000307896 ; ENSP00000311537 ; ENSG00000041988 . [Q8WTV1-3 ]
ENST00000377627 ; ENSP00000366854 ; ENSG00000041988 . [Q8WTV1-4 ]
GeneIDi 90326.
KEGGi hsa:90326.
UCSCi uc001aoc.3. human. [Q8WTV1-1 ]
uc001aod.3. human. [Q8WTV1-3 ]
uc001aoe.2. human. [Q8WTV1-4 ]

Organism-specific databases

CTDi 90326.
GeneCardsi GC01P006684.
HGNCi HGNC:20855. THAP3.
HPAi HPA044460.
MIMi 612532. gene.
neXtProti NX_Q8WTV1.
PharmGKBi PA134987111.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG79389.
GeneTreei ENSGT00530000063253.
HOVERGENi HBG100591.
InParanoidi Q8WTV1.
OMAi KAQRLVM.
OrthoDBi EOG7QVM4D.
PhylomeDBi Q8WTV1.
TreeFami TF330127.

Miscellaneous databases

ChiTaRSi THAP3. human.
GenomeRNAii 90326.
NextBioi 76664.
PROi Q8WTV1.
SOURCEi Search...

Gene expression databases

Bgeei Q8WTV1.
CleanExi HS_THAP3.
ExpressionAtlasi Q8WTV1. baseline and differential.
Genevestigatori Q8WTV1.

Family and domain databases

InterProi IPR026520. THAP3.
IPR006612. Znf_C2CH.
[Graphical view ]
PANTHERi PTHR23080:SF46. PTHR23080:SF46. 1 hit.
Pfami PF05485. THAP. 1 hit.
[Graphical view ]
SMARTi SM00692. DM3. 1 hit.
SM00980. THAP. 1 hit.
[Graphical view ]
PROSITEi PS50950. ZF_THAP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Teratocarcinoma.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 93-239 (ISOFORMS 1/2).
    Tissue: Brain and Uterus.
  4. "The THAP-zinc finger protein THAP1 associates with coactivator HCF-1 and O-GlcNAc transferase: a link between DYT6 and DYT3 dystonias."
    Mazars R., Gonzalez-de-Peredo A., Cayrol C., Lavigne A.C., Vogel J.L., Ortega N., Lacroix C., Gautier V., Huet G., Ray A., Monsarrat B., Kristie T.M., Girard J.P.
    J. Biol. Chem. 285:13364-13371(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HCFC1 AND OGT, TISSUE SPECIFICITY, IDENTIFICATION BY MASS SPECTROMETRY, FUNCTION, MUTAGENESIS OF 177-ASP--TYR-180.

Entry informationi

Entry nameiTHAP3_HUMAN
AccessioniPrimary (citable) accession number: Q8WTV1
Secondary accession number(s): Q569K1
, Q5TH66, Q5TH67, Q8N8T6, Q9BSC7, Q9Y3H2, Q9Y3H3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: March 1, 2002
Last modified: October 29, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3