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Q8WTV1 (THAP3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
THAP domain-containing protein 3
Gene names
Name:THAP3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length239 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. Ref.4

Subunit structure

Component of a THAP1/THAP3-HCFC1-OGT complex that contains at least, either THAP1 or THAP3, HCFC1 and OGT. Interacts directly with OGT and HCFC1 (via its HBM). Ref.4

Tissue specificity

Highly expressed in heart, skeletal muscle and placenta. Weaker expression in brain, kidney and liver. Ref.4

Sequence similarities

Contains 1 THAP-type zinc finger.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
   DomainZinc-finger
   LigandDNA-binding
Metal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

protein binding

Inferred from physical interaction Ref.4. Source: UniProtKB

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8WTV1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8WTV1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     89-89: Missing.
Note: Gene prediction based on EST data.
Isoform 3 (identifier: Q8WTV1-4)

The sequence of this isoform differs from the canonical sequence as follows:
     111-111: K → KTSPCRSQ
     147-168: VSPRRPQATEAVGRPTGPAGLR → AMLFNVENGTPASREALWLSEE
     169-239: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 239239THAP domain-containing protein 3
PRO_0000068644

Regions

Zinc finger1 – 8282THAP-type
Motif177 – 1804HCFC1-binding motif (HBM)

Natural variations

Alternative sequence891Missing in isoform 2.
VSP_015136
Alternative sequence1111K → KTSPCRSQ in isoform 3.
VSP_015137
Alternative sequence147 – 16822VSPRR…PAGLR → AMLFNVENGTPASREALWLS EE in isoform 3.
VSP_015138
Alternative sequence169 – 23971Missing in isoform 3.
VSP_015139

Experimental info

Mutagenesis177 – 1804DHSY → AAAA: Abolishes interaction with HCFC1. Ref.4
Mutagenesis1781H → A: Abolishes interaction with HCFC1.
Mutagenesis1801Y → A: Abolishes interaction with HCFC1.
Sequence conflict2271Q → R in AAH05114. Ref.3
Sequence conflict2271Q → R in AAH92427. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 9904C925DF233397

FASTA23927,059
        10         20         30         40         50         60 
MPKSCAARQC CNRYSSRRKQ LTFHRFPFSR PELLKEWVLN IGRGNFKPKQ HTVICSEHFR 

        70         80         90        100        110        120 
PECFSAFGNR KNLKHNAVPT VFAFQDPTQQ VRENTDPASE RGNASSSQKE KVLPEAGAGE 

       130        140        150        160        170        180 
DSPGRNMDTA LEELQLPPNA EGHVKQVSPR RPQATEAVGR PTGPAGLRRT PNKQPSDHSY 

       190        200        210        220        230 
ALLDLDSLKK KLFLTLKENE KLRKRLQAQR LVMRRMSSRL RACKGHQGLQ ARLGPEQQS 

« Hide

Isoform 2 [UniParc].

Checksum: 54667E778F734995
Show »

FASTA23826,931
Isoform 3 [UniParc].

Checksum: B6B9A4540DC5A8B4
Show »

FASTA17519,729

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Teratocarcinoma.
[2]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 93-239 (ISOFORMS 1/2).
Tissue: Brain and Uterus.
[4]"The THAP-zinc finger protein THAP1 associates with coactivator HCF-1 and O-GlcNAc transferase: a link between DYT6 and DYT3 dystonias."
Mazars R., Gonzalez-de-Peredo A., Cayrol C., Lavigne A.C., Vogel J.L., Ortega N., Lacroix C., Gautier V., Huet G., Ray A., Monsarrat B., Kristie T.M., Girard J.P.
J. Biol. Chem. 285:13364-13371(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH HCFC1 AND OGT, TISSUE SPECIFICITY, IDENTIFICATION BY MASS SPECTROMETRY, FUNCTION, MUTAGENESIS OF 177-ASP--TYR-180.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK096217 mRNA. Translation: BAC04727.1.
AL031447 Genomic DNA. Translation: CAI19468.1.
AL031447 Genomic DNA. Translation: CAI19469.1.
AL031447 Genomic DNA. Translation: CAI19470.1.
BC005114 mRNA. Translation: AAH05114.1.
BC092427 mRNA. Translation: AAH92427.1.
CCDSCCDS55572.1. [Q8WTV1-1]
CCDS55573.1. [Q8WTV1-3]
CCDS86.1. [Q8WTV1-4]
RefSeqNP_001182681.1. NM_001195752.1. [Q8WTV1-3]
NP_001182682.1. NM_001195753.1. [Q8WTV1-1]
NP_612359.2. NM_138350.3. [Q8WTV1-4]
XP_005263589.1. XM_005263532.1. [Q8WTV1-3]
UniGeneHs.689006.

3D structure databases

ProteinModelPortalQ8WTV1.
SMRQ8WTV1. Positions 1-82.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid124694. 4 interactions.
STRING9606.ENSP00000366854.

PTM databases

PhosphoSiteQ8WTV1.

Polymorphism databases

DMDM29839586.

Proteomic databases

PaxDbQ8WTV1.
PRIDEQ8WTV1.

Protocols and materials databases

DNASU90326.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000054650; ENSP00000054650; ENSG00000041988. [Q8WTV1-1]
ENST00000307896; ENSP00000311537; ENSG00000041988. [Q8WTV1-3]
ENST00000377627; ENSP00000366854; ENSG00000041988. [Q8WTV1-4]
GeneID90326.
KEGGhsa:90326.
UCSCuc001aoc.3. human. [Q8WTV1-1]
uc001aod.3. human. [Q8WTV1-3]
uc001aoe.2. human. [Q8WTV1-4]

Organism-specific databases

CTD90326.
GeneCardsGC01P006684.
HGNCHGNC:20855. THAP3.
HPAHPA044460.
MIM612532. gene.
neXtProtNX_Q8WTV1.
PharmGKBPA134987111.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG79389.
HOVERGENHBG100591.
InParanoidQ8WTV1.
OMAKAQRLVM.
OrthoDBEOG7QVM4D.
PhylomeDBQ8WTV1.
TreeFamTF330127.

Gene expression databases

ArrayExpressQ8WTV1.
BgeeQ8WTV1.
CleanExHS_THAP3.
GenevestigatorQ8WTV1.

Family and domain databases

InterProIPR026520. THAP3.
IPR006612. Znf_C2CH.
[Graphical view]
PANTHERPTHR23080:SF46. PTHR23080:SF46. 1 hit.
PfamPF05485. THAP. 1 hit.
[Graphical view]
SMARTSM00692. DM3. 1 hit.
SM00980. THAP. 1 hit.
[Graphical view]
PROSITEPS50950. ZF_THAP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSTHAP3. human.
GenomeRNAi90326.
NextBio76664.
PROQ8WTV1.
SOURCESearch...

Entry information

Entry nameTHAP3_HUMAN
AccessionPrimary (citable) accession number: Q8WTV1
Secondary accession number(s): Q569K1 expand/collapse secondary AC list , Q5TH66, Q5TH67, Q8N8T6, Q9BSC7, Q9Y3H2, Q9Y3H3
Entry history
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: March 1, 2002
Last modified: July 9, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM