Q8WTV1 (THAP3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
THAP domain-containing protein 3

Gene names

Name:

THAP3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	239 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. Ref.4
Subunit structure	Component of a THAP1/THAP3-HCFC1-OGT complex that contains at least, either THAP1 or THAP3, HCFC1 and OGT. Interacts directly with OGT and HCFC1 (via its HBM). Ref.4
Tissue specificity	Highly expressed in heart, skeletal muscle and placenta. Weaker expression in brain, kidney and liver. Ref.4
Sequence similarities	Contains 1 THAP-type zinc finger.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Domain	Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q8WTV1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q8WTV1-3)

The sequence of this isoform differs from the canonical sequence as follows:
     89-89: Missing.

Note: Gene prediction based on EST data.

Isoform 3 (identifier: Q8WTV1-4)

The sequence of this isoform differs from the canonical sequence as follows:
     111-111: K → KTSPCRSQ
     147-168: VSPRRPQATEAVGRPTGPAGLR → AMLFNVENGTPASREALWLSEE
     169-239: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 239	239	THAP domain-containing protein 3		PRO_0000068644
Regions
	Zinc finger	1 – 82	82	THAP-type
	Motif	177 – 180	4	HCFC1-binding motif (HBM)
Natural variations
	Alternative sequence	89	1	Missing in isoform 2.		VSP_015136
	Alternative sequence	111	1	K → KTSPCRSQ in isoform 3.		VSP_015137
	Alternative sequence	147 – 168	22	VSPRR…PAGLR → AMLFNVENGTPASREALWLS EE in isoform 3.		VSP_015138
	Alternative sequence	169 – 239	71	Missing in isoform 3.		VSP_015139
Experimental info
	Mutagenesis	177 – 180	4	DHSY → AAAA: Abolishes interaction with HCFC1. Ref.4
	Mutagenesis	178	1	H → A: Abolishes interaction with HCFC1.
	Mutagenesis	180	1	Y → A: Abolishes interaction with HCFC1.
	Sequence conflict	227	1	Q → R in AAH05114. Ref.3
	Sequence conflict	227	1	Q → R in AAH92427. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 9904C925DF233397	FASTA	239	27,059
	10 20 30 40 50 60 MPKSCAARQC CNRYSSRRKQ LTFHRFPFSR PELLKEWVLN IGRGNFKPKQ HTVICSEHFR 70 80 90 100 110 120 PECFSAFGNR KNLKHNAVPT VFAFQDPTQQ VRENTDPASE RGNASSSQKE KVLPEAGAGE 130 140 150 160 170 180 DSPGRNMDTA LEELQLPPNA EGHVKQVSPR RPQATEAVGR PTGPAGLRRT PNKQPSDHSY 190 200 210 220 230 ALLDLDSLKK KLFLTLKENE KLRKRLQAQR LVMRRMSSRL RACKGHQGLQ ARLGPEQQS
	Isoform 2 [UniParc]. Checksum: 54667E778F734995	FASTA	238	26,931
	10 20 30 40 50 60 MPKSCAARQC CNRYSSRRKQ LTFHRFPFSR PELLKEWVLN IGRGNFKPKQ HTVICSEHFR 70 80 90 100 110 120 PECFSAFGNR KNLKHNAVPT VFAFQDPTQV RENTDPASER GNASSSQKEK VLPEAGAGED 130 140 150 160 170 180 SPGRNMDTAL EELQLPPNAE GHVKQVSPRR PQATEAVGRP TGPAGLRRTP NKQPSDHSYA 190 200 210 220 230 LLDLDSLKKK LFLTLKENEK LRKRLQAQRL VMRRMSSRLR ACKGHQGLQA RLGPEQQS
	Isoform 3 [UniParc]. Checksum: B6B9A4540DC5A8B4	FASTA	175	19,729
	10 20 30 40 50 60 MPKSCAARQC CNRYSSRRKQ LTFHRFPFSR PELLKEWVLN IGRGNFKPKQ HTVICSEHFR 70 80 90 100 110 120 PECFSAFGNR KNLKHNAVPT VFAFQDPTQQ VRENTDPASE RGNASSSQKE KTSPCRSQVL 130 140 150 160 170 PEAGAGEDSP GRNMDTALEE LQLPPNAEGH VKQAMLFNVE NGTPASREAL WLSEE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Teratocarcinoma.
[2]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 93-239 (ISOFORMS 1/2). Tissue: Brain and Uterus.
[4]	"The THAP-zinc finger protein THAP1 associates with coactivator HCF-1 and O-GlcNAc transferase: a link between DYT6 and DYT3 dystonias." Mazars R., Gonzalez-de-Peredo A., Cayrol C., Lavigne A.C., Vogel J.L., Ortega N., Lacroix C., Gautier V., Huet G., Ray A., Monsarrat B., Kristie T.M., Girard J.P. J. Biol. Chem. 285:13364-13371(2010) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH HCFC1 AND OGT, TISSUE SPECIFICITY, MASS SPECTROMETRY, FUNCTION, MUTAGENESIS OF 177-ASP--TYR-180.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK096217 mRNA. Translation: BAC04727.1. AL031447 Genomic DNA. Translation: CAI19468.1. AL031447 Genomic DNA. Translation: CAI19469.1. AL031447 Genomic DNA. Translation: CAI19470.1. BC005114 mRNA. Translation: AAH05114.1. BC092427 mRNA. Translation: AAH92427.1.
IPI	IPI00008242. IPI00167574. IPI00643983.
RefSeq	NP_001182681.1. NM_001195752.1. NP_001182682.1. NM_001195753.1. NP_612359.2. NM_138350.3.
UniGene	Hs.689006.
3D structure databases
ProteinModelPortal	Q8WTV1.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000366854.
PTM databases
PhosphoSite	Q8WTV1.
Polymorphism databases
DMDM	29839586.
Proteomic databases
PaxDb	Q8WTV1.
PRIDE	Q8WTV1.
Protocols and materials databases
DNASU	90326.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000054650; ENSP00000054650; ENSG00000041988. ENST00000307896; ENSP00000311537; ENSG00000041988. ENST00000377627; ENSP00000366854; ENSG00000041988.
GeneID	90326.
KEGG	hsa:90326.
UCSC	uc001aoc.3. human. uc001aod.3. human. uc001aoe.2. human.
Organism-specific databases
CTD	90326.
GeneCards	GC01P006684.
HGNC	HGNC:20855. THAP3.
HPA	HPA044460.
MIM	612532. gene.
neXtProt	NX_Q8WTV1.
PharmGKB	PA134987111.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG79389.
HOVERGEN	HBG100591.
InParanoid	Q8WTV1.
OMA	VLNIGRA.
OrthoDB	EOG470TJ7.
PhylomeDB	Q8WTV1.
Gene expression databases
Bgee	Q8WTV1.
CleanEx	HS_THAP3.
Genevestigator	Q8WTV1.
GermOnline	ENSG00000041988. Homo sapiens.
Family and domain databases
InterPro	IPR026520. THAP3. IPR006612. Znf_C2CH. [Graphical view]
PANTHER	PTHR23080:SF12. PTHR23080:SF12. 1 hit.
Pfam	PF05485. THAP. 1 hit. [Graphical view]
SMART	SM00692. DM3. 1 hit. SM00980. THAP. 1 hit. [Graphical view]
PROSITE	PS50950. ZF_THAP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	THAP3. human.
GenomeRNAi	90326.
NextBio	76664.
SOURCE	Search...

Entry information

Entry name

THAP3_HUMAN

Accession

Primary (citable) accession number: Q8WTV1
Secondary accession number(s): Q569K1 , Q5TH66, Q5TH67, Q8N8T6, Q9BSC7, Q9Y3H2, Q9Y3H3

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 11, 2003
Last sequence update:	March 1, 2002
Last modified:	May 1, 2013
This is version 91 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.