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Protein

THAP domain-containing protein 3

Gene

THAP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1 – 82THAP-typePROSITE-ProRule annotationAdd BLAST82

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
THAP domain-containing protein 3
Gene namesi
Name:THAP3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:20855. THAP3.

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi177 – 180DHSY → AAAA: Abolishes interaction with HCFC1. 1 Publication4
Mutagenesisi178H → A: Abolishes interaction with HCFC1. 1
Mutagenesisi180Y → A: Abolishes interaction with HCFC1. 1

Organism-specific databases

DisGeNETi90326.
OpenTargetsiENSG00000041988.
PharmGKBiPA134987111.

Polymorphism and mutation databases

BioMutaiTHAP3.
DMDMi29839586.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000686441 – 239THAP domain-containing protein 3Add BLAST239

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei122PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8WTV1.
PaxDbiQ8WTV1.
PeptideAtlasiQ8WTV1.
PRIDEiQ8WTV1.

PTM databases

iPTMnetiQ8WTV1.
PhosphoSitePlusiQ8WTV1.

Expressioni

Tissue specificityi

Highly expressed in heart, skeletal muscle and placenta. Weaker expression in brain, kidney and liver.1 Publication

Gene expression databases

BgeeiENSG00000041988.
CleanExiHS_THAP3.
ExpressionAtlasiQ8WTV1. baseline and differential.
GenevisibleiQ8WTV1. HS.

Organism-specific databases

HPAiHPA044460.
HPA067114.

Interactioni

Subunit structurei

Component of a THAP1/THAP3-HCFC1-OGT complex that contains at least, either THAP1 or THAP3, HCFC1 and OGT. Interacts directly with OGT and HCFC1 (via its HBM).1 Publication

Protein-protein interaction databases

BioGridi124694. 4 interactors.
STRINGi9606.ENSP00000054650.

Structurei

3D structure databases

ProteinModelPortaliQ8WTV1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi177 – 180HCFC1-binding motif (HBM)4

Sequence similaritiesi

Contains 1 THAP-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1 – 82THAP-typePROSITE-ProRule annotationAdd BLAST82

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IRYI. Eukaryota.
ENOG410Y1BK. LUCA.
GeneTreeiENSGT00840000129785.
HOVERGENiHBG100591.
InParanoidiQ8WTV1.
OMAiRACKGHQ.
OrthoDBiEOG091G034R.
PhylomeDBiQ8WTV1.
TreeFamiTF330127.

Family and domain databases

InterProiIPR026520. THAP3.
IPR006612. Znf_C2CH.
[Graphical view]
PANTHERiPTHR23080:SF64. PTHR23080:SF64. 2 hits.
PfamiPF05485. THAP. 1 hit.
[Graphical view]
SMARTiSM00692. DM3. 1 hit.
SM00980. THAP. 1 hit.
[Graphical view]
PROSITEiPS50950. ZF_THAP. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WTV1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPKSCAARQC CNRYSSRRKQ LTFHRFPFSR PELLKEWVLN IGRGNFKPKQ
60 70 80 90 100
HTVICSEHFR PECFSAFGNR KNLKHNAVPT VFAFQDPTQQ VRENTDPASE
110 120 130 140 150
RGNASSSQKE KVLPEAGAGE DSPGRNMDTA LEELQLPPNA EGHVKQVSPR
160 170 180 190 200
RPQATEAVGR PTGPAGLRRT PNKQPSDHSY ALLDLDSLKK KLFLTLKENE
210 220 230
KLRKRLQAQR LVMRRMSSRL RACKGHQGLQ ARLGPEQQS
Length:239
Mass (Da):27,059
Last modified:March 1, 2002 - v1
Checksum:i9904C925DF233397
GO
Isoform 2 (identifier: Q8WTV1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     89-89: Missing.

Note: Gene prediction based on EST data.
Show »
Length:238
Mass (Da):26,931
Checksum:i54667E778F734995
GO
Isoform 3 (identifier: Q8WTV1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     111-111: K → KTSPCRSQ
     147-168: VSPRRPQATEAVGRPTGPAGLR → AMLFNVENGTPASREALWLSEE
     169-239: Missing.

Note: No experimental confirmation available.
Show »
Length:175
Mass (Da):19,729
Checksum:iB6B9A4540DC5A8B4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti227Q → R in AAH05114 (PubMed:15489334).Curated1
Sequence conflicti227Q → R in AAH92427 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01513689Missing in isoform 2. Curated1
Alternative sequenceiVSP_015137111K → KTSPCRSQ in isoform 3. 1 Publication1
Alternative sequenceiVSP_015138147 – 168VSPRR…PAGLR → AMLFNVENGTPASREALWLS EE in isoform 3. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_015139169 – 239Missing in isoform 3. 1 PublicationAdd BLAST71

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096217 mRNA. Translation: BAC04727.1.
AL031447 Genomic DNA. Translation: CAI19468.1.
AL031447 Genomic DNA. Translation: CAI19469.1.
AL031447 Genomic DNA. Translation: CAI19470.1.
BC005114 mRNA. Translation: AAH05114.1.
BC092427 mRNA. Translation: AAH92427.1.
CCDSiCCDS55572.1. [Q8WTV1-1]
CCDS55573.1. [Q8WTV1-3]
CCDS86.1. [Q8WTV1-4]
RefSeqiNP_001182681.1. NM_001195752.1. [Q8WTV1-3]
NP_001182682.1. NM_001195753.1. [Q8WTV1-1]
NP_612359.2. NM_138350.3. [Q8WTV1-4]
XP_005263589.1. XM_005263532.3. [Q8WTV1-3]
UniGeneiHs.689006.

Genome annotation databases

EnsembliENST00000054650; ENSP00000054650; ENSG00000041988. [Q8WTV1-1]
ENST00000307896; ENSP00000311537; ENSG00000041988. [Q8WTV1-3]
ENST00000377627; ENSP00000366854; ENSG00000041988. [Q8WTV1-4]
GeneIDi90326.
KEGGihsa:90326.
UCSCiuc001aoc.4. human. [Q8WTV1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096217 mRNA. Translation: BAC04727.1.
AL031447 Genomic DNA. Translation: CAI19468.1.
AL031447 Genomic DNA. Translation: CAI19469.1.
AL031447 Genomic DNA. Translation: CAI19470.1.
BC005114 mRNA. Translation: AAH05114.1.
BC092427 mRNA. Translation: AAH92427.1.
CCDSiCCDS55572.1. [Q8WTV1-1]
CCDS55573.1. [Q8WTV1-3]
CCDS86.1. [Q8WTV1-4]
RefSeqiNP_001182681.1. NM_001195752.1. [Q8WTV1-3]
NP_001182682.1. NM_001195753.1. [Q8WTV1-1]
NP_612359.2. NM_138350.3. [Q8WTV1-4]
XP_005263589.1. XM_005263532.3. [Q8WTV1-3]
UniGeneiHs.689006.

3D structure databases

ProteinModelPortaliQ8WTV1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124694. 4 interactors.
STRINGi9606.ENSP00000054650.

PTM databases

iPTMnetiQ8WTV1.
PhosphoSitePlusiQ8WTV1.

Polymorphism and mutation databases

BioMutaiTHAP3.
DMDMi29839586.

Proteomic databases

MaxQBiQ8WTV1.
PaxDbiQ8WTV1.
PeptideAtlasiQ8WTV1.
PRIDEiQ8WTV1.

Protocols and materials databases

DNASUi90326.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000054650; ENSP00000054650; ENSG00000041988. [Q8WTV1-1]
ENST00000307896; ENSP00000311537; ENSG00000041988. [Q8WTV1-3]
ENST00000377627; ENSP00000366854; ENSG00000041988. [Q8WTV1-4]
GeneIDi90326.
KEGGihsa:90326.
UCSCiuc001aoc.4. human. [Q8WTV1-1]

Organism-specific databases

CTDi90326.
DisGeNETi90326.
GeneCardsiTHAP3.
HGNCiHGNC:20855. THAP3.
HPAiHPA044460.
HPA067114.
MIMi612532. gene.
neXtProtiNX_Q8WTV1.
OpenTargetsiENSG00000041988.
PharmGKBiPA134987111.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IRYI. Eukaryota.
ENOG410Y1BK. LUCA.
GeneTreeiENSGT00840000129785.
HOVERGENiHBG100591.
InParanoidiQ8WTV1.
OMAiRACKGHQ.
OrthoDBiEOG091G034R.
PhylomeDBiQ8WTV1.
TreeFamiTF330127.

Miscellaneous databases

ChiTaRSiTHAP3. human.
GenomeRNAii90326.
PROiQ8WTV1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000041988.
CleanExiHS_THAP3.
ExpressionAtlasiQ8WTV1. baseline and differential.
GenevisibleiQ8WTV1. HS.

Family and domain databases

InterProiIPR026520. THAP3.
IPR006612. Znf_C2CH.
[Graphical view]
PANTHERiPTHR23080:SF64. PTHR23080:SF64. 2 hits.
PfamiPF05485. THAP. 1 hit.
[Graphical view]
SMARTiSM00692. DM3. 1 hit.
SM00980. THAP. 1 hit.
[Graphical view]
PROSITEiPS50950. ZF_THAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTHAP3_HUMAN
AccessioniPrimary (citable) accession number: Q8WTV1
Secondary accession number(s): Q569K1
, Q5TH66, Q5TH67, Q8N8T6, Q9BSC7, Q9Y3H2, Q9Y3H3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: March 1, 2002
Last modified: November 30, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.