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Protein

THAP domain-containing protein 3

Gene

THAP3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1 – 82THAP-typePROSITE-ProRule annotationAdd BLAST82

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
THAP domain-containing protein 3
Gene namesi
Name:THAP3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000041988.15
HGNCiHGNC:20855 THAP3
MIMi612532 gene
neXtProtiNX_Q8WTV1

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi177 – 180DHSY → AAAA: Abolishes interaction with HCFC1. 1 Publication4
Mutagenesisi178H → A: Abolishes interaction with HCFC1. 1
Mutagenesisi180Y → A: Abolishes interaction with HCFC1. 1

Organism-specific databases

DisGeNETi90326
OpenTargetsiENSG00000041988
PharmGKBiPA134987111

Polymorphism and mutation databases

BioMutaiTHAP3
DMDMi29839586

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000686441 – 239THAP domain-containing protein 3Add BLAST239

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei122PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8WTV1
PaxDbiQ8WTV1
PeptideAtlasiQ8WTV1
PRIDEiQ8WTV1
ProteomicsDBi74606
74607 [Q8WTV1-3]
74608 [Q8WTV1-4]

PTM databases

iPTMnetiQ8WTV1
PhosphoSitePlusiQ8WTV1

Expressioni

Tissue specificityi

Highly expressed in heart, skeletal muscle and placenta. Weaker expression in brain, kidney and liver.1 Publication

Gene expression databases

BgeeiENSG00000041988
CleanExiHS_THAP3
ExpressionAtlasiQ8WTV1 baseline and differential
GenevisibleiQ8WTV1 HS

Organism-specific databases

HPAiHPA067114

Interactioni

Subunit structurei

Component of a THAP1/THAP3-HCFC1-OGT complex that contains at least, either THAP1 or THAP3, HCFC1 and OGT. Interacts directly with OGT and HCFC1 (via its HBM).1 Publication

Protein-protein interaction databases

BioGridi124694, 6 interactors
ELMiQ8WTV1
STRINGi9606.ENSP00000054650

Structurei

3D structure databases

ProteinModelPortaliQ8WTV1
SMRiQ8WTV1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi177 – 180HCFC1-binding motif (HBM)4

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1 – 82THAP-typePROSITE-ProRule annotationAdd BLAST82

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IRYI Eukaryota
ENOG410Y1BK LUCA
GeneTreeiENSGT00840000129785
HOVERGENiHBG100591
InParanoidiQ8WTV1
OMAiVLNIGRA
OrthoDBiEOG091G034R
PhylomeDBiQ8WTV1
TreeFamiTF330127

Family and domain databases

Gene3Di3.30.40.180, 1 hit
InterProiView protein in InterPro
IPR026520 THAP3
IPR006612 THAP_Znf
IPR038441 THAP_Znf_sf
PANTHERiPTHR23080:SF64 PTHR23080:SF64, 1 hit
PfamiView protein in Pfam
PF05485 THAP, 1 hit
SMARTiView protein in SMART
SM00692 DM3, 1 hit
SM00980 THAP, 1 hit
PROSITEiView protein in PROSITE
PS50950 ZF_THAP, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WTV1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPKSCAARQC CNRYSSRRKQ LTFHRFPFSR PELLKEWVLN IGRGNFKPKQ
60 70 80 90 100
HTVICSEHFR PECFSAFGNR KNLKHNAVPT VFAFQDPTQQ VRENTDPASE
110 120 130 140 150
RGNASSSQKE KVLPEAGAGE DSPGRNMDTA LEELQLPPNA EGHVKQVSPR
160 170 180 190 200
RPQATEAVGR PTGPAGLRRT PNKQPSDHSY ALLDLDSLKK KLFLTLKENE
210 220 230
KLRKRLQAQR LVMRRMSSRL RACKGHQGLQ ARLGPEQQS
Length:239
Mass (Da):27,059
Last modified:March 1, 2002 - v1
Checksum:i9904C925DF233397
GO
Isoform 2 (identifier: Q8WTV1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     89-89: Missing.

Note: Gene prediction based on EST data.
Show »
Length:238
Mass (Da):26,931
Checksum:i54667E778F734995
GO
Isoform 3 (identifier: Q8WTV1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     111-111: K → KTSPCRSQ
     147-168: VSPRRPQATEAVGRPTGPAGLR → AMLFNVENGTPASREALWLSEE
     169-239: Missing.

Note: No experimental confirmation available.
Show »
Length:175
Mass (Da):19,729
Checksum:iB6B9A4540DC5A8B4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti227Q → R in AAH05114 (PubMed:15489334).Curated1
Sequence conflicti227Q → R in AAH92427 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01513689Missing in isoform 2. Curated1
Alternative sequenceiVSP_015137111K → KTSPCRSQ in isoform 3. 1 Publication1
Alternative sequenceiVSP_015138147 – 168VSPRR…PAGLR → AMLFNVENGTPASREALWLS EE in isoform 3. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_015139169 – 239Missing in isoform 3. 1 PublicationAdd BLAST71

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK096217 mRNA Translation: BAC04727.1
AL031447 Genomic DNA No translation available.
BC005114 mRNA Translation: AAH05114.1
BC092427 mRNA Translation: AAH92427.1
CCDSiCCDS55572.1 [Q8WTV1-1]
CCDS55573.1 [Q8WTV1-3]
CCDS86.1 [Q8WTV1-4]
RefSeqiNP_001182681.1, NM_001195752.1 [Q8WTV1-3]
NP_001182682.1, NM_001195753.1 [Q8WTV1-1]
NP_612359.2, NM_138350.3 [Q8WTV1-4]
XP_005263589.1, XM_005263532.3 [Q8WTV1-3]
UniGeneiHs.689006

Genome annotation databases

EnsembliENST00000054650; ENSP00000054650; ENSG00000041988 [Q8WTV1-1]
ENST00000307896; ENSP00000311537; ENSG00000041988 [Q8WTV1-3]
ENST00000377627; ENSP00000366854; ENSG00000041988 [Q8WTV1-4]
GeneIDi90326
KEGGihsa:90326
UCSCiuc001aoc.4 human [Q8WTV1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTHAP3_HUMAN
AccessioniPrimary (citable) accession number: Q8WTV1
Secondary accession number(s): Q569K1
, Q5TH66, Q5TH67, Q8N8T6, Q9BSC7, Q9Y3H2, Q9Y3H3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: March 1, 2002
Last modified: June 20, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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