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Protein

Scavenger receptor cysteine-rich domain-containing group B protein

Gene

SSC4D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Scavenger receptor cysteine-rich domain-containing group B protein1 PublicationImported
Alternative name(s):
Four scavenger receptor cysteine-rich domains-containing proteinImported
S4D-SRCRB1 Publication
Gene namesi
Name:SSC4DImported
Synonyms:SRCRB4DImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:14461. SSC4D.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37883.

Polymorphism and mutation databases

BioMutaiSRCRB4D.
DMDMi74751496.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4747Sequence analysisAdd
BLAST
Chaini48 – 575528Scavenger receptor cysteine-rich domain-containing group B proteinSequence analysisPRO_5000067535Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi83 ↔ 147PROSITE-ProRule annotation
Disulfide bondi96 ↔ 157PROSITE-ProRule annotation
Disulfide bondi127 ↔ 137PROSITE-ProRule annotation
Disulfide bondi214 ↔ 278PROSITE-ProRule annotation
Disulfide bondi227 ↔ 288PROSITE-ProRule annotation
Disulfide bondi258 ↔ 268PROSITE-ProRule annotation
Disulfide bondi369 ↔ 433PROSITE-ProRule annotation
Disulfide bondi382 ↔ 443PROSITE-ProRule annotation
Disulfide bondi413 ↔ 423PROSITE-ProRule annotation
Disulfide bondi498 ↔ 562PROSITE-ProRule annotation
Disulfide bondi511 ↔ 572PROSITE-ProRule annotation
Disulfide bondi542 ↔ 552PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiQ8WTU2.
MaxQBiQ8WTU2.
PaxDbiQ8WTU2.
PeptideAtlasiQ8WTU2.
PRIDEiQ8WTU2.

Expressioni

Inductioni

Not induced by a combination of IL1A/interleukin-1 alpha, IL6/interleukin-6 and dexamethasone.1 Publication

Gene expression databases

BgeeiQ8WTU2.
CleanExiHS_SRCRB4D.
GenevisibleiQ8WTU2. HS.

Organism-specific databases

HPAiHPA062611.

Interactioni

Protein-protein interaction databases

BioGridi126464. 1 interaction.
STRINGi9606.ENSP00000275560.

Structurei

3D structure databases

ProteinModelPortaliQ8WTU2.
SMRiQ8WTU2. Positions 56-575.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini58 – 158101SRCR 1PROSITE-ProRule annotationAdd
BLAST
Domaini189 – 289101SRCR 2PROSITE-ProRule annotationAdd
BLAST
Domaini344 – 444101SRCR 3PROSITE-ProRule annotationAdd
BLAST
Domaini473 – 573101SRCR 4PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 4 SRCR domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IHBC. Eukaryota.
ENOG410XQVR. LUCA.
GeneTreeiENSGT00840000129699.
HOGENOMiHOG000290652.
HOVERGENiHBG031373.
InParanoidiQ8WTU2.
OMAiWAAGKKS.
OrthoDBiEOG7RNK07.
PhylomeDBiQ8WTU2.
TreeFamiTF329295.

Family and domain databases

Gene3Di3.10.250.10. 4 hits.
InterProiIPR001190. SRCR.
IPR017448. SRCR-like_dom.
[Graphical view]
PfamiPF00530. SRCR. 4 hits.
[Graphical view]
PRINTSiPR00258. SPERACTRCPTR.
SMARTiSM00202. SR. 4 hits.
[Graphical view]
SUPFAMiSSF56487. SSF56487. 4 hits.
PROSITEiPS00420. SRCR_1. 4 hits.
PS50287. SRCR_2. 4 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q8WTU2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHKEAEMLIG PQLDEKRWGW RLGDGSAAPP FLPQALSFLL LLPLASALQP
60 70 80 90 100
TPLPFQELRL VGGPSRCRGR LEVMHGGSWG SVCDDDWDVV DANVVCRQLG
110 120 130 140 150
CGLALPVPRP LAFGQGRGPI LLDNVECRGQ EAALSECGSR GWGVHNCFHY
160 170 180 190 200
EDVAVLCDEF LPTQPPTRKM LTSRAPPTTL PNGKSEGSVR LVGGANLCQG
210 220 230 240 250
RVEILHSGLW GTVCDDDWGL PDAAVVCRQL GCGAAMAATT NAFFGYGTGH
260 270 280 290 300
ILLDNVHCEG GEPRLAACQS LGWGVHNCGH HEDAGALCAG LGPPTLTALP
310 320 330 340 350
SSATREDWAW QTDPSATGVG PQPSRETALL TTAAWAAGKK SGRLRLVGGP
360 370 380 390 400
GPCRGRVEVL HAGGWGTVCD DDWDFADARV ACREAGCGPA LGATGLGHFG
410 420 430 440 450
YGRGPVLLDN VGCAGTEARL SDCFHLGWGQ HNCGHHEDAG ALCAGPEELG
460 470 480 490 500
LQVQQDGSET TRVPTPRPRD GHLRLVNGAH RCEGRVELYL GQRWGTVCDD
510 520 530 540 550
AWDLRAAGVL CRQLGCGQAL AAPGEAHFGP GRGPILLDNV KCRGEESALL
560 570
LCSHIRWDAH NCDHSEDASV LCQPS
Length:575
Mass (Da):60,819
Last modified:March 1, 2002 - v1
Checksum:i013BD759EFDB4331
GO
Isoform 21 Publication (identifier: Q8WTU2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     271-274: LGWG → KTVS
     275-575: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:274
Mass (Da):29,264
Checksum:i71B000803F0117FF
GO

Sequence cautioni

The sequence AAH15651.1 differs from that shown.Intron retention.Curated
The sequence BAD18764.1 differs from that shown. Reason: Frameshift at position 25. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti520 – 5201L → I in BAD18764 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti128 – 1281R → H.
Corresponds to variant rs4728712 [ dbSNP | Ensembl ].
VAR_052063

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei271 – 2744LGWG → KTVS in isoform 2. 1 PublicationVSP_052695
Alternative sequencei275 – 575301Missing in isoform 2. 1 PublicationVSP_052696Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ306913
, AJ306914, AJ306915, AJ306916, AJ306917, AJ306918, AJ306919, AJ306920, AJ306921, AJ306922 Genomic DNA. Translation: CAC88128.1.
AJ312755 mRNA. Translation: CAC84764.1.
AK172783 mRNA. Translation: BAD18764.1. Frameshift.
AC005522 Genomic DNA. No translation available.
CH471220 Genomic DNA. Translation: EAW71806.1.
BC015651 mRNA. Translation: AAH15651.1. Sequence problems.
BC113840 mRNA. Translation: AAI13841.1.
CCDSiCCDS5585.1. [Q8WTU2-1]
RefSeqiNP_542782.1. NM_080744.1. [Q8WTU2-1]
UniGeneiHs.567684.

Genome annotation databases

EnsembliENST00000275560; ENSP00000275560; ENSG00000146700. [Q8WTU2-1]
GeneIDi136853.
KEGGihsa:136853.
UCSCiuc003ufb.4. human. [Q8WTU2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ306913
, AJ306914, AJ306915, AJ306916, AJ306917, AJ306918, AJ306919, AJ306920, AJ306921, AJ306922 Genomic DNA. Translation: CAC88128.1.
AJ312755 mRNA. Translation: CAC84764.1.
AK172783 mRNA. Translation: BAD18764.1. Frameshift.
AC005522 Genomic DNA. No translation available.
CH471220 Genomic DNA. Translation: EAW71806.1.
BC015651 mRNA. Translation: AAH15651.1. Sequence problems.
BC113840 mRNA. Translation: AAI13841.1.
CCDSiCCDS5585.1. [Q8WTU2-1]
RefSeqiNP_542782.1. NM_080744.1. [Q8WTU2-1]
UniGeneiHs.567684.

3D structure databases

ProteinModelPortaliQ8WTU2.
SMRiQ8WTU2. Positions 56-575.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126464. 1 interaction.
STRINGi9606.ENSP00000275560.

Polymorphism and mutation databases

BioMutaiSRCRB4D.
DMDMi74751496.

Proteomic databases

EPDiQ8WTU2.
MaxQBiQ8WTU2.
PaxDbiQ8WTU2.
PeptideAtlasiQ8WTU2.
PRIDEiQ8WTU2.

Protocols and materials databases

DNASUi136853.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000275560; ENSP00000275560; ENSG00000146700. [Q8WTU2-1]
GeneIDi136853.
KEGGihsa:136853.
UCSCiuc003ufb.4. human. [Q8WTU2-1]

Organism-specific databases

CTDi136853.
GeneCardsiSSC4D.
HGNCiHGNC:14461. SSC4D.
HPAiHPA062611.
MIMi607639. gene.
neXtProtiNX_Q8WTU2.
PharmGKBiPA37883.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHBC. Eukaryota.
ENOG410XQVR. LUCA.
GeneTreeiENSGT00840000129699.
HOGENOMiHOG000290652.
HOVERGENiHBG031373.
InParanoidiQ8WTU2.
OMAiWAAGKKS.
OrthoDBiEOG7RNK07.
PhylomeDBiQ8WTU2.
TreeFamiTF329295.

Miscellaneous databases

GenomeRNAii136853.
PROiQ8WTU2.
SOURCEiSearch...

Gene expression databases

BgeeiQ8WTU2.
CleanExiHS_SRCRB4D.
GenevisibleiQ8WTU2. HS.

Family and domain databases

Gene3Di3.10.250.10. 4 hits.
InterProiIPR001190. SRCR.
IPR017448. SRCR-like_dom.
[Graphical view]
PfamiPF00530. SRCR. 4 hits.
[Graphical view]
PRINTSiPR00258. SPERACTRCPTR.
SMARTiSM00202. SR. 4 hits.
[Graphical view]
SUPFAMiSSF56487. SSF56487. 4 hits.
PROSITEiPS00420. SRCR_1. 4 hits.
PS50287. SRCR_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of S4D-SRCRB, a new soluble member of the group B scavenger receptor cysteine-rich family (SRCR-SF) mapping to human chromosome 7q11.23."
    Padilla O., Pujana M.A., Lopez-de la Iglesia A., Gimferrer I., Arman M., Vila J.M., Places L., Vives J., Estivill X., Lozano F.
    Immunogenetics 54:621-634(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), INDUCTION.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Hepatoma1 Publication.
  3. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: BrainImported.

Entry informationi

Entry nameiSRB4D_HUMAN
AccessioniPrimary (citable) accession number: Q8WTU2
Secondary accession number(s): Q2HIZ5, Q6ZMG3, Q96BF5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: March 1, 2002
Last modified: July 6, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.