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Q8WTU0

- DDI1_HUMAN

UniProt

Q8WTU0 - DDI1_HUMAN

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Protein

Protein DDI1 homolog 1

Gene

DDI1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. aspartic-type endopeptidase activity Source: InterPro
Complete GO annotation...

Protein family/group databases

MEROPSiA28.003.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein DDI1 homolog 1
Gene namesi
Name:DDI1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:18961. DDI1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672003.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 396396Protein DDI1 homolog 1PRO_0000287086Add
BLAST

Proteomic databases

PaxDbiQ8WTU0.
PRIDEiQ8WTU0.

PTM databases

PhosphoSiteiQ8WTU0.

Expressioni

Gene expression databases

BgeeiQ8WTU0.
CleanExiHS_DDI1.
GenevestigatoriQ8WTU0.

Organism-specific databases

HPAiHPA055837.

Interactioni

Protein-protein interaction databases

BioGridi136043. 7 interactions.
DIPiDIP-60626N.
IntActiQ8WTU0. 2 interactions.
MINTiMINT-1479522.
STRINGi9606.ENSP00000302805.

Structurei

Secondary structure

1
396
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi245 – 2506
Beta strandi253 – 2597
Beta strandi267 – 2693
Helixi270 – 2756
Helixi279 – 2813
Helixi284 – 2863
Beta strandi297 – 30913
Beta strandi312 – 32110
Beta strandi325 – 3306
Helixi332 – 3376
Beta strandi341 – 3433
Turni344 – 3474
Beta strandi348 – 3503
Turni352 – 3543
Beta strandi357 – 3593
Helixi363 – 3653

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3S8IX-ray1.70A/B239-367[»]
ProteinModelPortaliQ8WTU0.
SMRiQ8WTU0. Positions 1-92, 241-367.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 8181Ubiquitin-likePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the DDI1 family.Curated
Contains 1 ubiquitin-like domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG276681.
GeneTreeiENSGT00510000047125.
HOGENOMiHOG000234736.
HOVERGENiHBG058638.
InParanoidiQ8WTU0.
KOiK11885.
OMAiAQIQIEG.
OrthoDBiEOG700886.
PhylomeDBiQ8WTU0.
TreeFamiTF333421.

Family and domain databases

InterProiIPR019103. Peptidase_aspartic_DDI1-type.
IPR021109. Peptidase_aspartic_dom.
IPR000626. Ubiquitin-like.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF09668. Asp_protease. 1 hit.
PF00240. ubiquitin. 1 hit.
[Graphical view]
SMARTiSM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF50630. SSF50630. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50053. UBIQUITIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WTU0 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLITVYCVRR DLSEVTFSLQ VSPDFELRNF KVLCEAESRV PVEEIQIIHM
60 70 80 90 100
ERLLIEDHCS LGSYGLKDGD IVVLLQKDNV GPRAPGRAPN QPRVDFSGIA
110 120 130 140 150
VPGTSSSRPQ HPGQQQQRTP AAQRSQGLAS GEKVAGLQGL GSPALIRSML
160 170 180 190 200
LSNPHDLSLL KERNPPLAEA LLSGSLETFS QVLMEQQREK ALREQERLRL
210 220 230 240 250
YTADPLDREA QAKIEEEIRQ QNIEENMNIA IEEAPESFGQ VTMLYINCKV
260 270 280 290 300
NGHPLKAFVD SGAQMTIMSQ ACAERCNIMR LVDRRWAGVA KGVGTQRIIG
310 320 330 340 350
RVHLAQIQIE GDFLQCSFSI LEDQPMDMLL GLDMLRRHQC SIDLKKNVLV
360 370 380 390
IGTTGTQTYF LPEGELPLCS RMVSGQDESS DKEITHSVMD SGRKEH
Length:396
Mass (Da):44,124
Last modified:March 1, 2002 - v1
Checksum:i1127CBF7ED3C705D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti153 – 1531N → K in AAP97303. 1 PublicationCurated
Sequence conflicti164 – 1641N → K in AAP97303. 1 PublicationCurated
Sequence conflicti170 – 1701A → T in AAP97303. 1 PublicationCurated
Sequence conflicti213 – 2131K → R in AAP97303. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti136 – 1361G → S.
Corresponds to variant rs7102675 [ dbSNP | Ensembl ].
VAR_032259
Natural varianti142 – 1421S → G.1 Publication
Corresponds to variant rs17856633 [ dbSNP | Ensembl ].
VAR_032260
Natural varianti239 – 2391G → E.1 Publication
Corresponds to variant rs17851870 [ dbSNP | Ensembl ].
VAR_032261

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK093336 mRNA. Translation: BAC04135.1.
AF429972 mRNA. Translation: AAP97303.1.
BC021172 mRNA. Translation: AAH21172.2.
BC021710 mRNA. Translation: AAH21710.1.
BC022017 mRNA. Translation: AAH22017.1.
BC022018 mRNA. Translation: AAH22018.1.
CCDSiCCDS31660.1.
RefSeqiNP_001001711.1. NM_001001711.2.
UniGeneiHs.591941.

Genome annotation databases

EnsembliENST00000302259; ENSP00000302805; ENSG00000170967.
GeneIDi414301.
KEGGihsa:414301.
UCSCiuc001phr.2. human.

Polymorphism databases

DMDMi74730631.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK093336 mRNA. Translation: BAC04135.1 .
AF429972 mRNA. Translation: AAP97303.1 .
BC021172 mRNA. Translation: AAH21172.2 .
BC021710 mRNA. Translation: AAH21710.1 .
BC022017 mRNA. Translation: AAH22017.1 .
BC022018 mRNA. Translation: AAH22018.1 .
CCDSi CCDS31660.1.
RefSeqi NP_001001711.1. NM_001001711.2.
UniGenei Hs.591941.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3S8I X-ray 1.70 A/B 239-367 [» ]
ProteinModelPortali Q8WTU0.
SMRi Q8WTU0. Positions 1-92, 241-367.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 136043. 7 interactions.
DIPi DIP-60626N.
IntActi Q8WTU0. 2 interactions.
MINTi MINT-1479522.
STRINGi 9606.ENSP00000302805.

Protein family/group databases

MEROPSi A28.003.

PTM databases

PhosphoSitei Q8WTU0.

Polymorphism databases

DMDMi 74730631.

Proteomic databases

PaxDbi Q8WTU0.
PRIDEi Q8WTU0.

Protocols and materials databases

DNASUi 414301.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000302259 ; ENSP00000302805 ; ENSG00000170967 .
GeneIDi 414301.
KEGGi hsa:414301.
UCSCi uc001phr.2. human.

Organism-specific databases

CTDi 414301.
GeneCardsi GC11P103907.
HGNCi HGNC:18961. DDI1.
HPAi HPA055837.
neXtProti NX_Q8WTU0.
PharmGKBi PA142672003.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG276681.
GeneTreei ENSGT00510000047125.
HOGENOMi HOG000234736.
HOVERGENi HBG058638.
InParanoidi Q8WTU0.
KOi K11885.
OMAi AQIQIEG.
OrthoDBi EOG700886.
PhylomeDBi Q8WTU0.
TreeFami TF333421.

Miscellaneous databases

GenomeRNAii 414301.
NextBioi 108557.
PROi Q8WTU0.

Gene expression databases

Bgeei Q8WTU0.
CleanExi HS_DDI1.
Genevestigatori Q8WTU0.

Family and domain databases

InterProi IPR019103. Peptidase_aspartic_DDI1-type.
IPR021109. Peptidase_aspartic_dom.
IPR000626. Ubiquitin-like.
IPR029071. Ubiquitin-rel_dom.
[Graphical view ]
Pfami PF09668. Asp_protease. 1 hit.
PF00240. ubiquitin. 1 hit.
[Graphical view ]
SMARTi SM00213. UBQ. 1 hit.
[Graphical view ]
SUPFAMi SSF50630. SSF50630. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEi PS50053. UBIQUITIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. Guo J.H., Yu L.
    Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS GLY-142 AND GLU-239.
    Tissue: Testis.
  4. "Retropepsin-like domain of human DDI1."
    Structural genomics consortium (SGC)
    Submitted (JUL-2011) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 239-367.

Entry informationi

Entry nameiDDI1_HUMAN
AccessioniPrimary (citable) accession number: Q8WTU0
Secondary accession number(s): Q7Z4U6, Q8WTS3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: March 1, 2002
Last modified: October 29, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3