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Q8WTU0 (DDI1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein DDI1 homolog 1
Gene names
Name:DDI1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length396 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the DDI1 family.

Contains 1 ubiquitin-like domain.

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processproteolysis

Inferred from electronic annotation. Source: InterPro

   Molecular_functionaspartic-type endopeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 396396Protein DDI1 homolog 1
PRO_0000287086

Regions

Domain1 – 8181Ubiquitin-like

Natural variations

Natural variant1361G → S.
Corresponds to variant rs7102675 [ dbSNP | Ensembl ].
VAR_032259
Natural variant1421S → G. Ref.3
Corresponds to variant rs17856633 [ dbSNP | Ensembl ].
VAR_032260
Natural variant2391G → E. Ref.3
Corresponds to variant rs17851870 [ dbSNP | Ensembl ].
VAR_032261

Experimental info

Sequence conflict1531N → K in AAP97303. Ref.2
Sequence conflict1641N → K in AAP97303. Ref.2
Sequence conflict1701A → T in AAP97303. Ref.2
Sequence conflict2131K → R in AAP97303. Ref.2

Secondary structure

.............................. 396
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q8WTU0 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 1127CBF7ED3C705D

FASTA39644,124
        10         20         30         40         50         60 
MLITVYCVRR DLSEVTFSLQ VSPDFELRNF KVLCEAESRV PVEEIQIIHM ERLLIEDHCS 

        70         80         90        100        110        120 
LGSYGLKDGD IVVLLQKDNV GPRAPGRAPN QPRVDFSGIA VPGTSSSRPQ HPGQQQQRTP 

       130        140        150        160        170        180 
AAQRSQGLAS GEKVAGLQGL GSPALIRSML LSNPHDLSLL KERNPPLAEA LLSGSLETFS 

       190        200        210        220        230        240 
QVLMEQQREK ALREQERLRL YTADPLDREA QAKIEEEIRQ QNIEENMNIA IEEAPESFGQ 

       250        260        270        280        290        300 
VTMLYINCKV NGHPLKAFVD SGAQMTIMSQ ACAERCNIMR LVDRRWAGVA KGVGTQRIIG 

       310        320        330        340        350        360 
RVHLAQIQIE GDFLQCSFSI LEDQPMDMLL GLDMLRRHQC SIDLKKNVLV IGTTGTQTYF 

       370        380        390 
LPEGELPLCS RMVSGQDESS DKEITHSVMD SGRKEH 

« Hide

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[2]Guo J.H., Yu L.
Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS GLY-142 AND GLU-239.
Tissue: Testis.
[4]"Retropepsin-like domain of human DDI1."
Structural genomics consortium (SGC)
Submitted (JUL-2011) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 239-367.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK093336 mRNA. Translation: BAC04135.1.
AF429972 mRNA. Translation: AAP97303.1.
BC021172 mRNA. Translation: AAH21172.2.
BC021710 mRNA. Translation: AAH21710.1.
BC022017 mRNA. Translation: AAH22017.1.
BC022018 mRNA. Translation: AAH22018.1.
RefSeqNP_001001711.1. NM_001001711.2.
UniGeneHs.591941.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3S8IX-ray1.70A/B239-367[»]
ProteinModelPortalQ8WTU0.
SMRQ8WTU0. Positions 1-92, 144-186, 241-367.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid136043. 1 interaction.
DIPDIP-60626N.
IntActQ8WTU0. 2 interactions.
MINTMINT-1479522.
STRING9606.ENSP00000302805.

Protein family/group databases

MEROPSA28.A01.

PTM databases

PhosphoSiteQ8WTU0.

Polymorphism databases

DMDM74730631.

Proteomic databases

PaxDbQ8WTU0.
PRIDEQ8WTU0.

Protocols and materials databases

DNASU414301.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000302259; ENSP00000302805; ENSG00000170967.
GeneID414301.
KEGGhsa:414301.
UCSCuc001phr.2. human.

Organism-specific databases

CTD414301.
GeneCardsGC11P103907.
HGNCHGNC:18961. DDI1.
HPAHPA055837.
neXtProtNX_Q8WTU0.
PharmGKBPA142672003.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG276681.
HOGENOMHOG000234736.
HOVERGENHBG058638.
InParanoidQ8WTU0.
KOK11885.
OMAAQIQIEG.
OrthoDBEOG700886.
PhylomeDBQ8WTU0.
TreeFamTF333421.

Gene expression databases

BgeeQ8WTU0.
CleanExHS_DDI1.
GenevestigatorQ8WTU0.

Family and domain databases

InterProIPR019103. Peptidase_aspartic_DDI1-type.
IPR021109. Peptidase_aspartic_dom.
IPR000626. Ubiquitin-like.
[Graphical view]
PfamPF09668. Asp_protease. 1 hit.
PF00240. ubiquitin. 1 hit.
[Graphical view]
SMARTSM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMSSF50630. SSF50630. 1 hit.
PROSITEPS50053. UBIQUITIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi414301.
NextBio108557.
PROQ8WTU0.

Entry information

Entry nameDDI1_HUMAN
AccessionPrimary (citable) accession number: Q8WTU0
Secondary accession number(s): Q7Z4U6, Q8WTS3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: March 1, 2002
Last modified: April 16, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM