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Q8WTU0

- DDI1_HUMAN

UniProt

Q8WTU0 - DDI1_HUMAN

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Protein
Protein DDI1 homolog 1
Gene
DDI1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. aspartic-type endopeptidase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Protein family/group databases

    MEROPSiA28.A01.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein DDI1 homolog 1
    Gene namesi
    Name:DDI1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:18961. DDI1.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142672003.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 396396Protein DDI1 homolog 1
    PRO_0000287086Add
    BLAST

    Proteomic databases

    PaxDbiQ8WTU0.
    PRIDEiQ8WTU0.

    PTM databases

    PhosphoSiteiQ8WTU0.

    Expressioni

    Gene expression databases

    BgeeiQ8WTU0.
    CleanExiHS_DDI1.
    GenevestigatoriQ8WTU0.

    Organism-specific databases

    HPAiHPA055837.

    Interactioni

    Protein-protein interaction databases

    BioGridi136043. 1 interaction.
    DIPiDIP-60626N.
    IntActiQ8WTU0. 2 interactions.
    MINTiMINT-1479522.
    STRINGi9606.ENSP00000302805.

    Structurei

    Secondary structure

    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi245 – 2506
    Beta strandi253 – 2597
    Beta strandi267 – 2693
    Helixi270 – 2756
    Helixi279 – 2813
    Helixi284 – 2863
    Beta strandi297 – 30913
    Beta strandi312 – 32110
    Beta strandi325 – 3306
    Helixi332 – 3376
    Beta strandi341 – 3433
    Turni344 – 3474
    Beta strandi348 – 3503
    Turni352 – 3543
    Beta strandi357 – 3593
    Helixi363 – 3653

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3S8IX-ray1.70A/B239-367[»]
    ProteinModelPortaliQ8WTU0.
    SMRiQ8WTU0. Positions 1-92, 241-367.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 8181Ubiquitin-like
    Add
    BLAST

    Sequence similaritiesi

    Belongs to the DDI1 family.

    Phylogenomic databases

    eggNOGiNOG276681.
    HOGENOMiHOG000234736.
    HOVERGENiHBG058638.
    InParanoidiQ8WTU0.
    KOiK11885.
    OMAiAQIQIEG.
    OrthoDBiEOG700886.
    PhylomeDBiQ8WTU0.
    TreeFamiTF333421.

    Family and domain databases

    InterProiIPR019103. Peptidase_aspartic_DDI1-type.
    IPR021109. Peptidase_aspartic_dom.
    IPR000626. Ubiquitin-like.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view]
    PfamiPF09668. Asp_protease. 1 hit.
    PF00240. ubiquitin. 1 hit.
    [Graphical view]
    SMARTiSM00213. UBQ. 1 hit.
    [Graphical view]
    SUPFAMiSSF50630. SSF50630. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEiPS50053. UBIQUITIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8WTU0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLITVYCVRR DLSEVTFSLQ VSPDFELRNF KVLCEAESRV PVEEIQIIHM    50
    ERLLIEDHCS LGSYGLKDGD IVVLLQKDNV GPRAPGRAPN QPRVDFSGIA 100
    VPGTSSSRPQ HPGQQQQRTP AAQRSQGLAS GEKVAGLQGL GSPALIRSML 150
    LSNPHDLSLL KERNPPLAEA LLSGSLETFS QVLMEQQREK ALREQERLRL 200
    YTADPLDREA QAKIEEEIRQ QNIEENMNIA IEEAPESFGQ VTMLYINCKV 250
    NGHPLKAFVD SGAQMTIMSQ ACAERCNIMR LVDRRWAGVA KGVGTQRIIG 300
    RVHLAQIQIE GDFLQCSFSI LEDQPMDMLL GLDMLRRHQC SIDLKKNVLV 350
    IGTTGTQTYF LPEGELPLCS RMVSGQDESS DKEITHSVMD SGRKEH 396
    Length:396
    Mass (Da):44,124
    Last modified:March 1, 2002 - v1
    Checksum:i1127CBF7ED3C705D
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti136 – 1361G → S.
    Corresponds to variant rs7102675 [ dbSNP | Ensembl ].
    VAR_032259
    Natural varianti142 – 1421S → G.1 Publication
    Corresponds to variant rs17856633 [ dbSNP | Ensembl ].
    VAR_032260
    Natural varianti239 – 2391G → E.1 Publication
    Corresponds to variant rs17851870 [ dbSNP | Ensembl ].
    VAR_032261

    Sequence conflict

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti153 – 1531N → K in AAP97303. 1 Publication
    Sequence conflicti164 – 1641N → K in AAP97303. 1 Publication
    Sequence conflicti170 – 1701A → T in AAP97303. 1 Publication
    Sequence conflicti213 – 2131K → R in AAP97303. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK093336 mRNA. Translation: BAC04135.1.
    AF429972 mRNA. Translation: AAP97303.1.
    BC021172 mRNA. Translation: AAH21172.2.
    BC021710 mRNA. Translation: AAH21710.1.
    BC022017 mRNA. Translation: AAH22017.1.
    BC022018 mRNA. Translation: AAH22018.1.
    CCDSiCCDS31660.1.
    RefSeqiNP_001001711.1. NM_001001711.2.
    UniGeneiHs.591941.

    Genome annotation databases

    EnsembliENST00000302259; ENSP00000302805; ENSG00000170967.
    GeneIDi414301.
    KEGGihsa:414301.
    UCSCiuc001phr.2. human.

    Polymorphism databases

    DMDMi74730631.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK093336 mRNA. Translation: BAC04135.1 .
    AF429972 mRNA. Translation: AAP97303.1 .
    BC021172 mRNA. Translation: AAH21172.2 .
    BC021710 mRNA. Translation: AAH21710.1 .
    BC022017 mRNA. Translation: AAH22017.1 .
    BC022018 mRNA. Translation: AAH22018.1 .
    CCDSi CCDS31660.1.
    RefSeqi NP_001001711.1. NM_001001711.2.
    UniGenei Hs.591941.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3S8I X-ray 1.70 A/B 239-367 [» ]
    ProteinModelPortali Q8WTU0.
    SMRi Q8WTU0. Positions 1-92, 241-367.
    ModBasei Search...

    Protein-protein interaction databases

    BioGridi 136043. 1 interaction.
    DIPi DIP-60626N.
    IntActi Q8WTU0. 2 interactions.
    MINTi MINT-1479522.
    STRINGi 9606.ENSP00000302805.

    Protein family/group databases

    MEROPSi A28.A01.

    PTM databases

    PhosphoSitei Q8WTU0.

    Polymorphism databases

    DMDMi 74730631.

    Proteomic databases

    PaxDbi Q8WTU0.
    PRIDEi Q8WTU0.

    Protocols and materials databases

    DNASUi 414301.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000302259 ; ENSP00000302805 ; ENSG00000170967 .
    GeneIDi 414301.
    KEGGi hsa:414301.
    UCSCi uc001phr.2. human.

    Organism-specific databases

    CTDi 414301.
    GeneCardsi GC11P103907.
    HGNCi HGNC:18961. DDI1.
    HPAi HPA055837.
    neXtProti NX_Q8WTU0.
    PharmGKBi PA142672003.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG276681.
    HOGENOMi HOG000234736.
    HOVERGENi HBG058638.
    InParanoidi Q8WTU0.
    KOi K11885.
    OMAi AQIQIEG.
    OrthoDBi EOG700886.
    PhylomeDBi Q8WTU0.
    TreeFami TF333421.

    Miscellaneous databases

    GenomeRNAii 414301.
    NextBioi 108557.
    PROi Q8WTU0.

    Gene expression databases

    Bgeei Q8WTU0.
    CleanExi HS_DDI1.
    Genevestigatori Q8WTU0.

    Family and domain databases

    InterProi IPR019103. Peptidase_aspartic_DDI1-type.
    IPR021109. Peptidase_aspartic_dom.
    IPR000626. Ubiquitin-like.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view ]
    Pfami PF09668. Asp_protease. 1 hit.
    PF00240. ubiquitin. 1 hit.
    [Graphical view ]
    SMARTi SM00213. UBQ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50630. SSF50630. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEi PS50053. UBIQUITIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    2. Guo J.H., Yu L.
      Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS GLY-142 AND GLU-239.
      Tissue: Testis.
    4. "Retropepsin-like domain of human DDI1."
      Structural genomics consortium (SGC)
      Submitted (JUL-2011) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 239-367.

    Entry informationi

    Entry nameiDDI1_HUMAN
    AccessioniPrimary (citable) accession number: Q8WTU0
    Secondary accession number(s): Q7Z4U6, Q8WTS3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 15, 2007
    Last sequence update: March 1, 2002
    Last modified: July 9, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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