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Protein

Protein DDI1 homolog 1

Gene

DDI1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000170967-MONOMER.

Protein family/group databases

MEROPSiA28.003.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein DDI1 homolog 1
Gene namesi
Name:DDI1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:18961. DDI1.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000170967.
PharmGKBiPA142672003.

Polymorphism and mutation databases

BioMutaiDDI1.
DMDMi74730631.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002870861 – 396Protein DDI1 homolog 1Add BLAST396

Proteomic databases

EPDiQ8WTU0.
MaxQBiQ8WTU0.
PaxDbiQ8WTU0.
PeptideAtlasiQ8WTU0.
PRIDEiQ8WTU0.

PTM databases

iPTMnetiQ8WTU0.
PhosphoSitePlusiQ8WTU0.

Expressioni

Gene expression databases

BgeeiENSG00000170967.
CleanExiHS_DDI1.
GenevisibleiQ8WTU0. HS.

Organism-specific databases

HPAiHPA055837.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CCL28Q9NRJ36EBI-748248,EBI-7783254
CYGBQ8WWM93EBI-748248,EBI-6309037
KLHL42Q9P2K63EBI-748248,EBI-739890
UBE2KP610863EBI-748248,EBI-473850

Protein-protein interaction databases

BioGridi136043. 14 interactors.
DIPiDIP-60626N.
IntActiQ8WTU0. 7 interactors.
MINTiMINT-1479522.
STRINGi9606.ENSP00000302805.

Structurei

Secondary structure

1396
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi245 – 250Combined sources6
Beta strandi253 – 259Combined sources7
Beta strandi267 – 269Combined sources3
Helixi270 – 275Combined sources6
Helixi279 – 281Combined sources3
Helixi284 – 286Combined sources3
Beta strandi297 – 309Combined sources13
Beta strandi312 – 321Combined sources10
Beta strandi325 – 330Combined sources6
Helixi332 – 337Combined sources6
Beta strandi341 – 343Combined sources3
Turni344 – 347Combined sources4
Beta strandi348 – 350Combined sources3
Turni352 – 354Combined sources3
Beta strandi357 – 359Combined sources3
Helixi363 – 365Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3S8IX-ray1.70A/B239-367[»]
ProteinModelPortaliQ8WTU0.
SMRiQ8WTU0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 81Ubiquitin-likePROSITE-ProRule annotationAdd BLAST81

Sequence similaritiesi

Belongs to the DDI1 family.Curated
Contains 1 ubiquitin-like domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0012. Eukaryota.
ENOG410XPA0. LUCA.
GeneTreeiENSGT00510000047125.
HOGENOMiHOG000234736.
HOVERGENiHBG058638.
InParanoidiQ8WTU0.
KOiK11885.
OMAiIEGDFLQ.
OrthoDBiEOG091G0CIP.
PhylomeDBiQ8WTU0.
TreeFamiTF333421.

Family and domain databases

CDDicd01796. DDI1_N. 1 hit.
Gene3Di2.40.70.10. 1 hit.
InterProiIPR033882. DDI1_N.
IPR019103. Peptidase_aspartic_DDI1-type.
IPR021109. Peptidase_aspartic_dom.
IPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
[Graphical view]
PfamiPF09668. Asp_protease. 1 hit.
PF00240. ubiquitin. 1 hit.
[Graphical view]
SMARTiSM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF50630. SSF50630. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50053. UBIQUITIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WTU0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLITVYCVRR DLSEVTFSLQ VSPDFELRNF KVLCEAESRV PVEEIQIIHM
60 70 80 90 100
ERLLIEDHCS LGSYGLKDGD IVVLLQKDNV GPRAPGRAPN QPRVDFSGIA
110 120 130 140 150
VPGTSSSRPQ HPGQQQQRTP AAQRSQGLAS GEKVAGLQGL GSPALIRSML
160 170 180 190 200
LSNPHDLSLL KERNPPLAEA LLSGSLETFS QVLMEQQREK ALREQERLRL
210 220 230 240 250
YTADPLDREA QAKIEEEIRQ QNIEENMNIA IEEAPESFGQ VTMLYINCKV
260 270 280 290 300
NGHPLKAFVD SGAQMTIMSQ ACAERCNIMR LVDRRWAGVA KGVGTQRIIG
310 320 330 340 350
RVHLAQIQIE GDFLQCSFSI LEDQPMDMLL GLDMLRRHQC SIDLKKNVLV
360 370 380 390
IGTTGTQTYF LPEGELPLCS RMVSGQDESS DKEITHSVMD SGRKEH
Length:396
Mass (Da):44,124
Last modified:March 1, 2002 - v1
Checksum:i1127CBF7ED3C705D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti153N → K in AAP97303 (Ref. 2) Curated1
Sequence conflicti164N → K in AAP97303 (Ref. 2) Curated1
Sequence conflicti170A → T in AAP97303 (Ref. 2) Curated1
Sequence conflicti213K → R in AAP97303 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_032259136G → S.Corresponds to variant rs7102675dbSNPEnsembl.1
Natural variantiVAR_032260142S → G.1 PublicationCorresponds to variant rs17856633dbSNPEnsembl.1
Natural variantiVAR_032261239G → E.1 PublicationCorresponds to variant rs17851870dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093336 mRNA. Translation: BAC04135.1.
AF429972 mRNA. Translation: AAP97303.1.
BC021172 mRNA. Translation: AAH21172.2.
BC021710 mRNA. Translation: AAH21710.1.
BC022017 mRNA. Translation: AAH22017.1.
BC022018 mRNA. Translation: AAH22018.1.
CCDSiCCDS31660.1.
RefSeqiNP_001001711.1. NM_001001711.2.
UniGeneiHs.591941.

Genome annotation databases

EnsembliENST00000302259; ENSP00000302805; ENSG00000170967.
GeneIDi414301.
KEGGihsa:414301.
UCSCiuc001phr.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093336 mRNA. Translation: BAC04135.1.
AF429972 mRNA. Translation: AAP97303.1.
BC021172 mRNA. Translation: AAH21172.2.
BC021710 mRNA. Translation: AAH21710.1.
BC022017 mRNA. Translation: AAH22017.1.
BC022018 mRNA. Translation: AAH22018.1.
CCDSiCCDS31660.1.
RefSeqiNP_001001711.1. NM_001001711.2.
UniGeneiHs.591941.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3S8IX-ray1.70A/B239-367[»]
ProteinModelPortaliQ8WTU0.
SMRiQ8WTU0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi136043. 14 interactors.
DIPiDIP-60626N.
IntActiQ8WTU0. 7 interactors.
MINTiMINT-1479522.
STRINGi9606.ENSP00000302805.

Protein family/group databases

MEROPSiA28.003.

PTM databases

iPTMnetiQ8WTU0.
PhosphoSitePlusiQ8WTU0.

Polymorphism and mutation databases

BioMutaiDDI1.
DMDMi74730631.

Proteomic databases

EPDiQ8WTU0.
MaxQBiQ8WTU0.
PaxDbiQ8WTU0.
PeptideAtlasiQ8WTU0.
PRIDEiQ8WTU0.

Protocols and materials databases

DNASUi414301.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302259; ENSP00000302805; ENSG00000170967.
GeneIDi414301.
KEGGihsa:414301.
UCSCiuc001phr.3. human.

Organism-specific databases

CTDi414301.
GeneCardsiDDI1.
HGNCiHGNC:18961. DDI1.
HPAiHPA055837.
neXtProtiNX_Q8WTU0.
OpenTargetsiENSG00000170967.
PharmGKBiPA142672003.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0012. Eukaryota.
ENOG410XPA0. LUCA.
GeneTreeiENSGT00510000047125.
HOGENOMiHOG000234736.
HOVERGENiHBG058638.
InParanoidiQ8WTU0.
KOiK11885.
OMAiIEGDFLQ.
OrthoDBiEOG091G0CIP.
PhylomeDBiQ8WTU0.
TreeFamiTF333421.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000170967-MONOMER.

Miscellaneous databases

GenomeRNAii414301.
PROiQ8WTU0.

Gene expression databases

BgeeiENSG00000170967.
CleanExiHS_DDI1.
GenevisibleiQ8WTU0. HS.

Family and domain databases

CDDicd01796. DDI1_N. 1 hit.
Gene3Di2.40.70.10. 1 hit.
InterProiIPR033882. DDI1_N.
IPR019103. Peptidase_aspartic_DDI1-type.
IPR021109. Peptidase_aspartic_dom.
IPR029071. Ubiquitin-rel_dom.
IPR000626. Ubiquitin_dom.
[Graphical view]
PfamiPF09668. Asp_protease. 1 hit.
PF00240. ubiquitin. 1 hit.
[Graphical view]
SMARTiSM00213. UBQ. 1 hit.
[Graphical view]
SUPFAMiSSF50630. SSF50630. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50053. UBIQUITIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDDI1_HUMAN
AccessioniPrimary (citable) accession number: Q8WTU0
Secondary accession number(s): Q7Z4U6, Q8WTS3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: March 1, 2002
Last modified: November 30, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.