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Q8WTT2

- NOC3L_HUMAN

UniProt

Q8WTT2 - NOC3L_HUMAN

Protein

Nucleolar complex protein 3 homolog

Gene

NOC3L

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    May be required for adipogenesis.By similarity

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB

    GO - Biological processi

    1. fat cell differentiation Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nucleolar complex protein 3 homolog
    Short name:
    NOC3 protein homolog
    Alternative name(s):
    Factor for adipocyte differentiation 24
    NOC3-like protein
    Nucleolar complex-associated protein 3-like protein
    Gene namesi
    Name:NOC3L
    Synonyms:AD24, C10orf117, FAD24
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 10

    Organism-specific databases

    HGNCiHGNC:24034. NOC3L.

    Subcellular locationi

    GO - Cellular componenti

    1. nuclear speck Source: UniProtKB-SubCell
    2. nucleolus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134887727.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 800800Nucleolar complex protein 3 homologPRO_0000173474Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei787 – 7871Phosphoserine3 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ8WTT2.
    PaxDbiQ8WTT2.
    PRIDEiQ8WTT2.

    2D gel databases

    SWISS-2DPAGEQ8WTT2.

    PTM databases

    PhosphoSiteiQ8WTT2.

    Expressioni

    Tissue specificityi

    Expressed in colon, heart, kidney, liver, lung, placenta, skeletal muscle, small intestine, spleen and thymus.1 Publication

    Gene expression databases

    ArrayExpressiQ8WTT2.
    BgeeiQ8WTT2.
    CleanExiHS_NOC3L.
    GenevestigatoriQ8WTT2.

    Interactioni

    Protein-protein interaction databases

    BioGridi122131. 12 interactions.
    IntActiQ8WTT2. 4 interactions.
    MINTiMINT-3046174.
    STRINGi9606.ENSP00000360412.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8WTT2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili451 – 49040Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CBF/MAK21 family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiCOG5117.
    HOGENOMiHOG000293323.
    HOVERGENiHBG082040.
    InParanoidiQ8WTT2.
    KOiK14834.
    OrthoDBiEOG71CFKH.
    PhylomeDBiQ8WTT2.
    TreeFamiTF318817.

    Family and domain databases

    InterProiIPR016024. ARM-type_fold.
    IPR005612. CCAAT-binding_factor.
    IPR011501. NOC3p.
    IPR016903. Nucleolar_cplx-assoc_3.
    [Graphical view]
    PfamiPF03914. CBF. 1 hit.
    PF07540. NOC3p. 1 hit.
    [Graphical view]
    PIRSFiPIRSF028977. Nucleolar_complex_p3. 1 hit.
    SUPFAMiSSF48371. SSF48371. 3 hits.

    Sequencei

    Sequence statusi: Complete.

    Q8WTT2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKARRNKKQI PSFRKLIKTS KVKLENKLKN KQFKQQSTLK KYRKEQRKLR    50
    QAVKDAVSKK PIPLENPKEK RPGKRIEREE EEEEEALPLD MMDEDDLQLM 100
    KDLGQRVSFL TRDLSSSEPV HAKKRKHERI IDKYEKIPRT LQTAPEKELI 150
    HLLPIKDKSG IIPQTREKPV TDSNKDEEDQ EEERELEEEI IEDPIQELTI 200
    EEHLIERKKK LQEKKMHIAA LASAILSDPE NNIKKLKELR SMLMEQDPDV 250
    AVTVRKLVIV SLMELFKDIT PSYKIRPLTE AEKSTKTRKE TQKLREFEEG 300
    LVSQYKFYLE NLEQMVKDWK QRKLKKSNVV SLKAYKGLAE VAVKSLCELL 350
    VALPHFNFHN NIIVLIVPLM NDMSKLISEM CCEAVKKLFK QDKLGQASLG 400
    VIKVISGFVK GRNYEVRPEM LKTFLCLRIK EVEVKKDTED INKPKKFMTF 450
    KEKRKSLSRM QRKWKKAEEK LERELREAEA SESTEKKLKL HTETLNIVFV 500
    TYFRILKKAQ RSPLLPAVLE GLAKFAHLIN VEFFDDLLVV LHTLIESGDL 550
    SYQESLHCVQ TAFHILSGQG DVLNIDPLKF YTHLYKTLFK LHAGATNEGV 600
    EIVLQCLDVM LTKRRKQVSQ QRALAFIKRL CTLALHVLPN SSIGILATTR 650
    ILMHTFPKTD LLLDSESQGS GVFLPELDEP EYCNAQNTAL WELHALRRHY 700
    HPIVQRFAAH LIAGAPSEGS GALKPELSRR SATELFEAYS MAEMTFNPPV 750
    ESSNPKIKGK FLQGDSFLNE DLNQLIKRYS SEVATESPLD FTKYLKTSLH 800
    Length:800
    Mass (Da):92,548
    Last modified:March 1, 2002 - v1
    Checksum:i4471F5C6246F53C9
    GO

    Sequence cautioni

    The sequence BAB14291.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAB15599.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti194 – 1941P → L.
    Corresponds to variant rs12572897 [ dbSNP | Ensembl ].
    VAR_023549
    Natural varianti444 – 4441P → R.
    Corresponds to variant rs11187895 [ dbSNP | Ensembl ].
    VAR_048621
    Natural varianti472 – 4721E → A.1 Publication
    Corresponds to variant rs3758526 [ dbSNP | Ensembl ].
    VAR_023550
    Natural varianti504 – 5041R → I.
    Corresponds to variant rs11187892 [ dbSNP | Ensembl ].
    VAR_048622
    Natural varianti655 – 6551T → S.
    Corresponds to variant rs12259382 [ dbSNP | Ensembl ].
    VAR_048623
    Natural varianti695 – 6951A → T.
    Corresponds to variant rs17517578 [ dbSNP | Ensembl ].
    VAR_048624

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB077992 mRNA. Translation: BAB84194.1.
    AL355341 Genomic DNA. Translation: CAD13194.1.
    BC049850 mRNA. Translation: AAH49850.1.
    AK022882 mRNA. Translation: BAB14291.1. Different initiation.
    AK026953 mRNA. Translation: BAB15599.1. Different initiation.
    CCDSiCCDS7433.1.
    RefSeqiNP_071896.8. NM_022451.9.
    UniGeneiHs.74899.

    Genome annotation databases

    EnsembliENST00000371361; ENSP00000360412; ENSG00000173145.
    GeneIDi64318.
    KEGGihsa:64318.
    UCSCiuc001kjq.1. human.

    Polymorphism databases

    DMDMi74751495.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB077992 mRNA. Translation: BAB84194.1 .
    AL355341 Genomic DNA. Translation: CAD13194.1 .
    BC049850 mRNA. Translation: AAH49850.1 .
    AK022882 mRNA. Translation: BAB14291.1 . Different initiation.
    AK026953 mRNA. Translation: BAB15599.1 . Different initiation.
    CCDSi CCDS7433.1.
    RefSeqi NP_071896.8. NM_022451.9.
    UniGenei Hs.74899.

    3D structure databases

    ProteinModelPortali Q8WTT2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122131. 12 interactions.
    IntActi Q8WTT2. 4 interactions.
    MINTi MINT-3046174.
    STRINGi 9606.ENSP00000360412.

    PTM databases

    PhosphoSitei Q8WTT2.

    Polymorphism databases

    DMDMi 74751495.

    2D gel databases

    SWISS-2DPAGE Q8WTT2.

    Proteomic databases

    MaxQBi Q8WTT2.
    PaxDbi Q8WTT2.
    PRIDEi Q8WTT2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000371361 ; ENSP00000360412 ; ENSG00000173145 .
    GeneIDi 64318.
    KEGGi hsa:64318.
    UCSCi uc001kjq.1. human.

    Organism-specific databases

    CTDi 64318.
    GeneCardsi GC10M096083.
    H-InvDB HIX0035465.
    HGNCi HGNC:24034. NOC3L.
    MIMi 610769. gene.
    neXtProti NX_Q8WTT2.
    PharmGKBi PA134887727.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5117.
    HOGENOMi HOG000293323.
    HOVERGENi HBG082040.
    InParanoidi Q8WTT2.
    KOi K14834.
    OrthoDBi EOG71CFKH.
    PhylomeDBi Q8WTT2.
    TreeFami TF318817.

    Miscellaneous databases

    ChiTaRSi NOC3L. human.
    GenomeRNAii 64318.
    NextBioi 66225.
    PROi Q8WTT2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8WTT2.
    Bgeei Q8WTT2.
    CleanExi HS_NOC3L.
    Genevestigatori Q8WTT2.

    Family and domain databases

    InterProi IPR016024. ARM-type_fold.
    IPR005612. CCAAT-binding_factor.
    IPR011501. NOC3p.
    IPR016903. Nucleolar_cplx-assoc_3.
    [Graphical view ]
    Pfami PF03914. CBF. 1 hit.
    PF07540. NOC3p. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF028977. Nucleolar_complex_p3. 1 hit.
    SUPFAMi SSF48371. SSF48371. 3 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Fad24, a mammalian homolog of Noc3p, is a positive regulator in adipocyte differentiation."
      Tominaga K., Johmura Y., Nishizuka M., Imagawa M.
      J. Cell Sci. 117:6217-6226(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    2. "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
      , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
      Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Uterus.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 318-800, VARIANT ALA-472.
      Tissue: Hepatoma and Teratocarcinoma.
    5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-787, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-787, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-787, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiNOC3L_HUMAN
    AccessioniPrimary (citable) accession number: Q8WTT2
    Secondary accession number(s): Q9H5M6, Q9H9D8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2005
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 10
      Human chromosome 10: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3