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Q8WTT2

- NOC3L_HUMAN

UniProt

Q8WTT2 - NOC3L_HUMAN

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Protein

Nucleolar complex protein 3 homolog

Gene
NOC3L, AD24, C10orf117, FAD24
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

May be required for adipogenesis By similarity.

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB

GO - Biological processi

  1. fat cell differentiation Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleolar complex protein 3 homolog
Short name:
NOC3 protein homolog
Alternative name(s):
Factor for adipocyte differentiation 24
NOC3-like protein
Nucleolar complex-associated protein 3-like protein
Gene namesi
Name:NOC3L
Synonyms:AD24, C10orf117, FAD24
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:24034. NOC3L.

Subcellular locationi

Nucleusnucleolus. Nucleus speckle 2 Publications

GO - Cellular componenti

  1. nuclear speck Source: UniProtKB-SubCell
  2. nucleolus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134887727.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 800800Nucleolar complex protein 3 homologPRO_0000173474Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei787 – 7871Phosphoserine3 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ8WTT2.
PaxDbiQ8WTT2.
PRIDEiQ8WTT2.

2D gel databases

SWISS-2DPAGEQ8WTT2.

PTM databases

PhosphoSiteiQ8WTT2.

Expressioni

Tissue specificityi

Expressed in colon, heart, kidney, liver, lung, placenta, skeletal muscle, small intestine, spleen and thymus.1 Publication

Gene expression databases

ArrayExpressiQ8WTT2.
BgeeiQ8WTT2.
CleanExiHS_NOC3L.
GenevestigatoriQ8WTT2.

Interactioni

Protein-protein interaction databases

BioGridi122131. 12 interactions.
IntActiQ8WTT2. 4 interactions.
MINTiMINT-3046174.
STRINGi9606.ENSP00000360412.

Structurei

3D structure databases

ProteinModelPortaliQ8WTT2.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili451 – 49040 Reviewed predictionAdd
BLAST

Sequence similaritiesi

Belongs to the CBF/MAK21 family.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG5117.
HOGENOMiHOG000293323.
HOVERGENiHBG082040.
InParanoidiQ8WTT2.
KOiK14834.
OrthoDBiEOG71CFKH.
PhylomeDBiQ8WTT2.
TreeFamiTF318817.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR005612. CCAAT-binding_factor.
IPR011501. NOC3p.
IPR016903. Nucleolar_cplx-assoc_3.
[Graphical view]
PfamiPF03914. CBF. 1 hit.
PF07540. NOC3p. 1 hit.
[Graphical view]
PIRSFiPIRSF028977. Nucleolar_complex_p3. 1 hit.
SUPFAMiSSF48371. SSF48371. 3 hits.

Sequencei

Sequence statusi: Complete.

Q8WTT2-1 [UniParc]FASTAAdd to Basket

« Hide

MKARRNKKQI PSFRKLIKTS KVKLENKLKN KQFKQQSTLK KYRKEQRKLR    50
QAVKDAVSKK PIPLENPKEK RPGKRIEREE EEEEEALPLD MMDEDDLQLM 100
KDLGQRVSFL TRDLSSSEPV HAKKRKHERI IDKYEKIPRT LQTAPEKELI 150
HLLPIKDKSG IIPQTREKPV TDSNKDEEDQ EEERELEEEI IEDPIQELTI 200
EEHLIERKKK LQEKKMHIAA LASAILSDPE NNIKKLKELR SMLMEQDPDV 250
AVTVRKLVIV SLMELFKDIT PSYKIRPLTE AEKSTKTRKE TQKLREFEEG 300
LVSQYKFYLE NLEQMVKDWK QRKLKKSNVV SLKAYKGLAE VAVKSLCELL 350
VALPHFNFHN NIIVLIVPLM NDMSKLISEM CCEAVKKLFK QDKLGQASLG 400
VIKVISGFVK GRNYEVRPEM LKTFLCLRIK EVEVKKDTED INKPKKFMTF 450
KEKRKSLSRM QRKWKKAEEK LERELREAEA SESTEKKLKL HTETLNIVFV 500
TYFRILKKAQ RSPLLPAVLE GLAKFAHLIN VEFFDDLLVV LHTLIESGDL 550
SYQESLHCVQ TAFHILSGQG DVLNIDPLKF YTHLYKTLFK LHAGATNEGV 600
EIVLQCLDVM LTKRRKQVSQ QRALAFIKRL CTLALHVLPN SSIGILATTR 650
ILMHTFPKTD LLLDSESQGS GVFLPELDEP EYCNAQNTAL WELHALRRHY 700
HPIVQRFAAH LIAGAPSEGS GALKPELSRR SATELFEAYS MAEMTFNPPV 750
ESSNPKIKGK FLQGDSFLNE DLNQLIKRYS SEVATESPLD FTKYLKTSLH 800
Length:800
Mass (Da):92,548
Last modified:March 1, 2002 - v1
Checksum:i4471F5C6246F53C9
GO

Sequence cautioni

The sequence BAB14291.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAB15599.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti194 – 1941P → L.
Corresponds to variant rs12572897 [ dbSNP | Ensembl ].
VAR_023549
Natural varianti444 – 4441P → R.
Corresponds to variant rs11187895 [ dbSNP | Ensembl ].
VAR_048621
Natural varianti472 – 4721E → A.1 Publication
Corresponds to variant rs3758526 [ dbSNP | Ensembl ].
VAR_023550
Natural varianti504 – 5041R → I.
Corresponds to variant rs11187892 [ dbSNP | Ensembl ].
VAR_048622
Natural varianti655 – 6551T → S.
Corresponds to variant rs12259382 [ dbSNP | Ensembl ].
VAR_048623
Natural varianti695 – 6951A → T.
Corresponds to variant rs17517578 [ dbSNP | Ensembl ].
VAR_048624

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB077992 mRNA. Translation: BAB84194.1.
AL355341 Genomic DNA. Translation: CAD13194.1.
BC049850 mRNA. Translation: AAH49850.1.
AK022882 mRNA. Translation: BAB14291.1. Different initiation.
AK026953 mRNA. Translation: BAB15599.1. Different initiation.
CCDSiCCDS7433.1.
RefSeqiNP_071896.8. NM_022451.9.
UniGeneiHs.74899.

Genome annotation databases

EnsembliENST00000371361; ENSP00000360412; ENSG00000173145.
GeneIDi64318.
KEGGihsa:64318.
UCSCiuc001kjq.1. human.

Polymorphism databases

DMDMi74751495.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB077992 mRNA. Translation: BAB84194.1 .
AL355341 Genomic DNA. Translation: CAD13194.1 .
BC049850 mRNA. Translation: AAH49850.1 .
AK022882 mRNA. Translation: BAB14291.1 . Different initiation.
AK026953 mRNA. Translation: BAB15599.1 . Different initiation.
CCDSi CCDS7433.1.
RefSeqi NP_071896.8. NM_022451.9.
UniGenei Hs.74899.

3D structure databases

ProteinModelPortali Q8WTT2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122131. 12 interactions.
IntActi Q8WTT2. 4 interactions.
MINTi MINT-3046174.
STRINGi 9606.ENSP00000360412.

PTM databases

PhosphoSitei Q8WTT2.

Polymorphism databases

DMDMi 74751495.

2D gel databases

SWISS-2DPAGE Q8WTT2.

Proteomic databases

MaxQBi Q8WTT2.
PaxDbi Q8WTT2.
PRIDEi Q8WTT2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000371361 ; ENSP00000360412 ; ENSG00000173145 .
GeneIDi 64318.
KEGGi hsa:64318.
UCSCi uc001kjq.1. human.

Organism-specific databases

CTDi 64318.
GeneCardsi GC10M096083.
H-InvDB HIX0035465.
HGNCi HGNC:24034. NOC3L.
MIMi 610769. gene.
neXtProti NX_Q8WTT2.
PharmGKBi PA134887727.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5117.
HOGENOMi HOG000293323.
HOVERGENi HBG082040.
InParanoidi Q8WTT2.
KOi K14834.
OrthoDBi EOG71CFKH.
PhylomeDBi Q8WTT2.
TreeFami TF318817.

Miscellaneous databases

ChiTaRSi NOC3L. human.
GenomeRNAii 64318.
NextBioi 66225.
PROi Q8WTT2.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8WTT2.
Bgeei Q8WTT2.
CleanExi HS_NOC3L.
Genevestigatori Q8WTT2.

Family and domain databases

InterProi IPR016024. ARM-type_fold.
IPR005612. CCAAT-binding_factor.
IPR011501. NOC3p.
IPR016903. Nucleolar_cplx-assoc_3.
[Graphical view ]
Pfami PF03914. CBF. 1 hit.
PF07540. NOC3p. 1 hit.
[Graphical view ]
PIRSFi PIRSF028977. Nucleolar_complex_p3. 1 hit.
SUPFAMi SSF48371. SSF48371. 3 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Fad24, a mammalian homolog of Noc3p, is a positive regulator in adipocyte differentiation."
    Tominaga K., Johmura Y., Nishizuka M., Imagawa M.
    J. Cell Sci. 117:6217-6226(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  2. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 318-800, VARIANT ALA-472.
    Tissue: Hepatoma and Teratocarcinoma.
  5. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-787, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-787, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-787, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiNOC3L_HUMAN
AccessioniPrimary (citable) accession number: Q8WTT2
Secondary accession number(s): Q9H5M6, Q9H9D8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: March 1, 2002
Last modified: September 3, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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