Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Nucleolar complex protein 3 homolog

Gene

NOC3L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be required for adipogenesis.By similarity

GO - Molecular functioni

  • chromatin binding Source: GO_Central
  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000173145-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleolar complex protein 3 homolog
Short name:
NOC3 protein homolog
Alternative name(s):
Factor for adipocyte differentiation 24
NOC3-like protein
Nucleolar complex-associated protein 3-like protein
Gene namesi
Name:NOC3L
Synonyms:AD24, C10orf117, FAD24
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:24034. NOC3L.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi64318.
OpenTargetsiENSG00000173145.
PharmGKBiPA134887727.

Polymorphism and mutation databases

BioMutaiNOC3L.
DMDMi74751495.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001734741 – 800Nucleolar complex protein 3 homologAdd BLAST800

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei787PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8WTT2.
MaxQBiQ8WTT2.
PaxDbiQ8WTT2.
PeptideAtlasiQ8WTT2.
PRIDEiQ8WTT2.

2D gel databases

SWISS-2DPAGEQ8WTT2.

PTM databases

iPTMnetiQ8WTT2.
PhosphoSitePlusiQ8WTT2.
SwissPalmiQ8WTT2.

Expressioni

Tissue specificityi

Expressed in colon, heart, kidney, liver, lung, placenta, skeletal muscle, small intestine, spleen and thymus.1 Publication

Gene expression databases

BgeeiENSG00000173145.
CleanExiHS_NOC3L.
GenevisibleiQ8WTT2. HS.

Organism-specific databases

HPAiHPA063958.
HPA067638.

Interactioni

Protein-protein interaction databases

BioGridi122131. 47 interactors.
IntActiQ8WTT2. 8 interactors.
MINTiMINT-3046174.
STRINGi9606.ENSP00000360412.

Structurei

3D structure databases

ProteinModelPortaliQ8WTT2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili451 – 490Sequence analysisAdd BLAST40

Sequence similaritiesi

Belongs to the CBF/MAK21 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2153. Eukaryota.
COG5117. LUCA.
GeneTreeiENSGT00390000008540.
HOGENOMiHOG000293323.
HOVERGENiHBG082040.
InParanoidiQ8WTT2.
KOiK14834.
OMAiIFSQKAR.
OrthoDBiEOG091G087E.
PhylomeDBiQ8WTT2.
TreeFamiTF318817.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR005612. CCAAT-binding_factor.
IPR011501. Noc3_N.
IPR016903. Nucleolar_cplx-assoc_3.
[Graphical view]
PfamiPF03914. CBF. 1 hit.
PF07540. NOC3p. 1 hit.
[Graphical view]
PIRSFiPIRSF028977. Nucleolar_complex_p3. 1 hit.
SUPFAMiSSF48371. SSF48371. 3 hits.

Sequencei

Sequence statusi: Complete.

Q8WTT2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKARRNKKQI PSFRKLIKTS KVKLENKLKN KQFKQQSTLK KYRKEQRKLR
60 70 80 90 100
QAVKDAVSKK PIPLENPKEK RPGKRIEREE EEEEEALPLD MMDEDDLQLM
110 120 130 140 150
KDLGQRVSFL TRDLSSSEPV HAKKRKHERI IDKYEKIPRT LQTAPEKELI
160 170 180 190 200
HLLPIKDKSG IIPQTREKPV TDSNKDEEDQ EEERELEEEI IEDPIQELTI
210 220 230 240 250
EEHLIERKKK LQEKKMHIAA LASAILSDPE NNIKKLKELR SMLMEQDPDV
260 270 280 290 300
AVTVRKLVIV SLMELFKDIT PSYKIRPLTE AEKSTKTRKE TQKLREFEEG
310 320 330 340 350
LVSQYKFYLE NLEQMVKDWK QRKLKKSNVV SLKAYKGLAE VAVKSLCELL
360 370 380 390 400
VALPHFNFHN NIIVLIVPLM NDMSKLISEM CCEAVKKLFK QDKLGQASLG
410 420 430 440 450
VIKVISGFVK GRNYEVRPEM LKTFLCLRIK EVEVKKDTED INKPKKFMTF
460 470 480 490 500
KEKRKSLSRM QRKWKKAEEK LERELREAEA SESTEKKLKL HTETLNIVFV
510 520 530 540 550
TYFRILKKAQ RSPLLPAVLE GLAKFAHLIN VEFFDDLLVV LHTLIESGDL
560 570 580 590 600
SYQESLHCVQ TAFHILSGQG DVLNIDPLKF YTHLYKTLFK LHAGATNEGV
610 620 630 640 650
EIVLQCLDVM LTKRRKQVSQ QRALAFIKRL CTLALHVLPN SSIGILATTR
660 670 680 690 700
ILMHTFPKTD LLLDSESQGS GVFLPELDEP EYCNAQNTAL WELHALRRHY
710 720 730 740 750
HPIVQRFAAH LIAGAPSEGS GALKPELSRR SATELFEAYS MAEMTFNPPV
760 770 780 790 800
ESSNPKIKGK FLQGDSFLNE DLNQLIKRYS SEVATESPLD FTKYLKTSLH
Length:800
Mass (Da):92,548
Last modified:March 1, 2002 - v1
Checksum:i4471F5C6246F53C9
GO

Sequence cautioni

The sequence BAB14291 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAB15599 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_023549194P → L.Corresponds to variant rs12572897dbSNPEnsembl.1
Natural variantiVAR_048621444P → R.Corresponds to variant rs11187895dbSNPEnsembl.1
Natural variantiVAR_023550472E → A.1 PublicationCorresponds to variant rs3758526dbSNPEnsembl.1
Natural variantiVAR_048622504R → I.Corresponds to variant rs11187892dbSNPEnsembl.1
Natural variantiVAR_048623655T → S.Corresponds to variant rs12259382dbSNPEnsembl.1
Natural variantiVAR_048624695A → T.Corresponds to variant rs17517578dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB077992 mRNA. Translation: BAB84194.1.
AL355341 Genomic DNA. Translation: CAD13194.1.
BC049850 mRNA. Translation: AAH49850.1.
AK022882 mRNA. Translation: BAB14291.1. Different initiation.
AK026953 mRNA. Translation: BAB15599.1. Different initiation.
CCDSiCCDS7433.1.
RefSeqiNP_071896.8. NM_022451.10.
UniGeneiHs.74899.

Genome annotation databases

EnsembliENST00000371361; ENSP00000360412; ENSG00000173145.
GeneIDi64318.
KEGGihsa:64318.
UCSCiuc001kjq.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB077992 mRNA. Translation: BAB84194.1.
AL355341 Genomic DNA. Translation: CAD13194.1.
BC049850 mRNA. Translation: AAH49850.1.
AK022882 mRNA. Translation: BAB14291.1. Different initiation.
AK026953 mRNA. Translation: BAB15599.1. Different initiation.
CCDSiCCDS7433.1.
RefSeqiNP_071896.8. NM_022451.10.
UniGeneiHs.74899.

3D structure databases

ProteinModelPortaliQ8WTT2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122131. 47 interactors.
IntActiQ8WTT2. 8 interactors.
MINTiMINT-3046174.
STRINGi9606.ENSP00000360412.

PTM databases

iPTMnetiQ8WTT2.
PhosphoSitePlusiQ8WTT2.
SwissPalmiQ8WTT2.

Polymorphism and mutation databases

BioMutaiNOC3L.
DMDMi74751495.

2D gel databases

SWISS-2DPAGEQ8WTT2.

Proteomic databases

EPDiQ8WTT2.
MaxQBiQ8WTT2.
PaxDbiQ8WTT2.
PeptideAtlasiQ8WTT2.
PRIDEiQ8WTT2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371361; ENSP00000360412; ENSG00000173145.
GeneIDi64318.
KEGGihsa:64318.
UCSCiuc001kjq.2. human.

Organism-specific databases

CTDi64318.
DisGeNETi64318.
GeneCardsiNOC3L.
H-InvDBHIX0035465.
HGNCiHGNC:24034. NOC3L.
HPAiHPA063958.
HPA067638.
MIMi610769. gene.
neXtProtiNX_Q8WTT2.
OpenTargetsiENSG00000173145.
PharmGKBiPA134887727.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2153. Eukaryota.
COG5117. LUCA.
GeneTreeiENSGT00390000008540.
HOGENOMiHOG000293323.
HOVERGENiHBG082040.
InParanoidiQ8WTT2.
KOiK14834.
OMAiIFSQKAR.
OrthoDBiEOG091G087E.
PhylomeDBiQ8WTT2.
TreeFamiTF318817.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000173145-MONOMER.

Miscellaneous databases

ChiTaRSiNOC3L. human.
GenomeRNAii64318.
PROiQ8WTT2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000173145.
CleanExiHS_NOC3L.
GenevisibleiQ8WTT2. HS.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR005612. CCAAT-binding_factor.
IPR011501. Noc3_N.
IPR016903. Nucleolar_cplx-assoc_3.
[Graphical view]
PfamiPF03914. CBF. 1 hit.
PF07540. NOC3p. 1 hit.
[Graphical view]
PIRSFiPIRSF028977. Nucleolar_complex_p3. 1 hit.
SUPFAMiSSF48371. SSF48371. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiNOC3L_HUMAN
AccessioniPrimary (citable) accession number: Q8WTT2
Secondary accession number(s): Q9H5M6, Q9H9D8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: March 1, 2002
Last modified: November 2, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.