Q8WTT2 (NOC3L_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nucleolar complex protein 3 homolog
Short name=NOC3 protein homolog

Alternative name(s):
Factor for adipocyte differentiation 24
NOC3-like protein
Nucleolar complex-associated protein 3-like protein

Gene names

Name:	NOC3L
Synonyms:	AD24, C10orf117, FAD24

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	800 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be required for adipogenesis By similarity.
Subcellular location	Nucleus › nucleolus. Nucleus speckle Ref.1 Ref.5.
Tissue specificity	Expressed in colon, heart, kidney, liver, lung, placenta, skeletal muscle, small intestine, spleen and thymus. Ref.1
Sequence similarities	Belongs to the CBF/MAK21 family.
Sequence caution	The sequence BAB14291.1 differs from that shown. Reason: Erroneous initiation. The sequence BAB15599.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Domain	Coiled coil
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	fat cell differentiation Inferred from electronic annotation. Source: Compara
Cellular_component	nuclear speck Inferred from electronic annotation. Source: UniProtKB-SubCell nucleolus Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 800	800	Nucleolar complex protein 3 homolog		PRO_0000173474
Regions
	Coiled coil	451 – 490	40	Potential
Amino acid modifications
	Modified residue	787	1	Phosphoserine Ref.6 Ref.7 Ref.8
Natural variations
	Natural variant	194	1	P → L. Corresponds to variant rs12572897 [ dbSNP | Ensembl ].		VAR_023549
	Natural variant	444	1	P → R. Corresponds to variant rs11187895 [ dbSNP | Ensembl ].		VAR_048621
	Natural variant	472	1	E → A. Ref.4 Corresponds to variant rs3758526 [ dbSNP | Ensembl ].		VAR_023550
	Natural variant	504	1	R → I. Corresponds to variant rs11187892 [ dbSNP | Ensembl ].		VAR_048622
	Natural variant	655	1	T → S. Corresponds to variant rs12259382 [ dbSNP | Ensembl ].		VAR_048623
	Natural variant	695	1	A → T. Corresponds to variant rs17517578 [ dbSNP | Ensembl ].		VAR_048624

Sequences

	Sequence		Length	Mass (Da)
	Q8WTT2 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: 4471F5C6246F53C9	FASTA	800	92,548
	10 20 30 40 50 60 MKARRNKKQI PSFRKLIKTS KVKLENKLKN KQFKQQSTLK KYRKEQRKLR QAVKDAVSKK 70 80 90 100 110 120 PIPLENPKEK RPGKRIEREE EEEEEALPLD MMDEDDLQLM KDLGQRVSFL TRDLSSSEPV 130 140 150 160 170 180 HAKKRKHERI IDKYEKIPRT LQTAPEKELI HLLPIKDKSG IIPQTREKPV TDSNKDEEDQ 190 200 210 220 230 240 EEERELEEEI IEDPIQELTI EEHLIERKKK LQEKKMHIAA LASAILSDPE NNIKKLKELR 250 260 270 280 290 300 SMLMEQDPDV AVTVRKLVIV SLMELFKDIT PSYKIRPLTE AEKSTKTRKE TQKLREFEEG 310 320 330 340 350 360 LVSQYKFYLE NLEQMVKDWK QRKLKKSNVV SLKAYKGLAE VAVKSLCELL VALPHFNFHN 370 380 390 400 410 420 NIIVLIVPLM NDMSKLISEM CCEAVKKLFK QDKLGQASLG VIKVISGFVK GRNYEVRPEM 430 440 450 460 470 480 LKTFLCLRIK EVEVKKDTED INKPKKFMTF KEKRKSLSRM QRKWKKAEEK LERELREAEA 490 500 510 520 530 540 SESTEKKLKL HTETLNIVFV TYFRILKKAQ RSPLLPAVLE GLAKFAHLIN VEFFDDLLVV 550 560 570 580 590 600 LHTLIESGDL SYQESLHCVQ TAFHILSGQG DVLNIDPLKF YTHLYKTLFK LHAGATNEGV 610 620 630 640 650 660 EIVLQCLDVM LTKRRKQVSQ QRALAFIKRL CTLALHVLPN SSIGILATTR ILMHTFPKTD 670 680 690 700 710 720 LLLDSESQGS GVFLPELDEP EYCNAQNTAL WELHALRRHY HPIVQRFAAH LIAGAPSEGS 730 740 750 760 770 780 GALKPELSRR SATELFEAYS MAEMTFNPPV ESSNPKIKGK FLQGDSFLNE DLNQLIKRYS 790 800 SEVATESPLD FTKYLKTSLH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Fad24, a mammalian homolog of Noc3p, is a positive regulator in adipocyte differentiation." Tominaga K., Johmura Y., Nishizuka M., Imagawa M. J. Cell Sci. 117:6217-6226(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[2]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Uterus.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 318-800, VARIANT ALA-472. Tissue: Hepatoma and Teratocarcinoma.
[5]	"Functional proteomic analysis of human nucleolus." Scherl A., Coute Y., Deon C., Calle A., Kindbeiter K., Sanchez J.-C., Greco A., Hochstrasser D.F., Diaz J.-J. Mol. Biol. Cell 13:4100-4109(2002) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[6]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-787, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[7]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-787, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[8]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-787, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB077992 mRNA. Translation: BAB84194.1. AL355341 Genomic DNA. Translation: CAD13194.1. BC049850 mRNA. Translation: AAH49850.1. AK022882 mRNA. Translation: BAB14291.1. Different initiation. AK026953 mRNA. Translation: BAB15599.1. Different initiation.
IPI	IPI00102815.
RefSeq	NP_071896.8. NM_022451.9.
UniGene	Hs.74899.
3D structure databases
ProteinModelPortal	Q8WTT2.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8WTT2. 3 interactions.
MINT	MINT-3046174.
STRING	9606.ENSP00000360412.
PTM databases
PhosphoSite	Q8WTT2.
Polymorphism databases
DMDM	74751495.
2D gel databases
SWISS-2DPAGE	Q8WTT2.
Proteomic databases
PaxDb	Q8WTT2.
PRIDE	Q8WTT2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000371361; ENSP00000360412; ENSG00000173145.
GeneID	64318.
KEGG	hsa:64318.
UCSC	uc001kjq.1. human.
Organism-specific databases
CTD	64318.
GeneCards	GC10M096083.
H-InvDB	HIX0035465.
HGNC	HGNC:24034. NOC3L.
MIM	610769. gene.
neXtProt	NX_Q8WTT2.
PharmGKB	PA134887727.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5117.
HOGENOM	HOG000293323.
HOVERGEN	HBG082040.
InParanoid	Q8WTT2.
KO	K14834.
OrthoDB	EOG4VHK66.
PhylomeDB	Q8WTT2.
Gene expression databases
ArrayExpress	Q8WTT2.
Bgee	Q8WTT2.
CleanEx	HS_NOC3L.
Genevestigator	Q8WTT2.
GermOnline	ENSG00000173145. Homo sapiens.
Family and domain databases
InterPro	IPR005612. CCAAT-binding_factor. IPR011501. NOC3p. IPR016903. Nucleolar_cplx-assoc_3. [Graphical view]
Pfam	PF03914. CBF. 1 hit. PF07540. NOC3p. 1 hit. [Graphical view]
PIRSF	PIRSF028977. Nucleolar_complex_p3. 1 hit.
ProtoNet	Search...
Other
ChiTaRS	NOC3L. human.
GenomeRNAi	64318.
NextBio	66225.
SOURCE	Search...

Entry information

Entry name

NOC3L_HUMAN

Accession

Primary (citable) accession number: Q8WTT2
Secondary accession number(s): Q9H5M6, Q9H9D8

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2005
Last sequence update:	March 1, 2002
Last modified:	May 29, 2013
This is version 97 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.