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Q8WTT2 (NOC3L_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nucleolar complex protein 3 homolog

Short name=NOC3 protein homolog
Alternative name(s):
Factor for adipocyte differentiation 24
NOC3-like protein
Nucleolar complex-associated protein 3-like protein
Gene names
Name:NOC3L
Synonyms:AD24, C10orf117, FAD24
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length800 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be required for adipogenesis By similarity.

Subcellular location

Nucleusnucleolus. Nucleus speckle Ref.1 Ref.5.

Tissue specificity

Expressed in colon, heart, kidney, liver, lung, placenta, skeletal muscle, small intestine, spleen and thymus. Ref.1

Sequence similarities

Belongs to the CBF/MAK21 family.

Sequence caution

The sequence BAB14291.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAB15599.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentNucleus
   Coding sequence diversityPolymorphism
   DomainCoiled coil
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processfat cell differentiation

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentnuclear speck

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleolus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionpoly(A) RNA binding

Inferred from direct assay PubMed 22658674PubMed 22681889. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 800800Nucleolar complex protein 3 homolog
PRO_0000173474

Regions

Coiled coil451 – 49040 Potential

Amino acid modifications

Modified residue7871Phosphoserine Ref.6 Ref.7 Ref.8

Natural variations

Natural variant1941P → L.
Corresponds to variant rs12572897 [ dbSNP | Ensembl ].
VAR_023549
Natural variant4441P → R.
Corresponds to variant rs11187895 [ dbSNP | Ensembl ].
VAR_048621
Natural variant4721E → A. Ref.4
Corresponds to variant rs3758526 [ dbSNP | Ensembl ].
VAR_023550
Natural variant5041R → I.
Corresponds to variant rs11187892 [ dbSNP | Ensembl ].
VAR_048622
Natural variant6551T → S.
Corresponds to variant rs12259382 [ dbSNP | Ensembl ].
VAR_048623
Natural variant6951A → T.
Corresponds to variant rs17517578 [ dbSNP | Ensembl ].
VAR_048624

Sequences

Sequence LengthMass (Da)Tools
Q8WTT2 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 4471F5C6246F53C9

FASTA80092,548
        10         20         30         40         50         60 
MKARRNKKQI PSFRKLIKTS KVKLENKLKN KQFKQQSTLK KYRKEQRKLR QAVKDAVSKK 

        70         80         90        100        110        120 
PIPLENPKEK RPGKRIEREE EEEEEALPLD MMDEDDLQLM KDLGQRVSFL TRDLSSSEPV 

       130        140        150        160        170        180 
HAKKRKHERI IDKYEKIPRT LQTAPEKELI HLLPIKDKSG IIPQTREKPV TDSNKDEEDQ 

       190        200        210        220        230        240 
EEERELEEEI IEDPIQELTI EEHLIERKKK LQEKKMHIAA LASAILSDPE NNIKKLKELR 

       250        260        270        280        290        300 
SMLMEQDPDV AVTVRKLVIV SLMELFKDIT PSYKIRPLTE AEKSTKTRKE TQKLREFEEG 

       310        320        330        340        350        360 
LVSQYKFYLE NLEQMVKDWK QRKLKKSNVV SLKAYKGLAE VAVKSLCELL VALPHFNFHN 

       370        380        390        400        410        420 
NIIVLIVPLM NDMSKLISEM CCEAVKKLFK QDKLGQASLG VIKVISGFVK GRNYEVRPEM 

       430        440        450        460        470        480 
LKTFLCLRIK EVEVKKDTED INKPKKFMTF KEKRKSLSRM QRKWKKAEEK LERELREAEA 

       490        500        510        520        530        540 
SESTEKKLKL HTETLNIVFV TYFRILKKAQ RSPLLPAVLE GLAKFAHLIN VEFFDDLLVV 

       550        560        570        580        590        600 
LHTLIESGDL SYQESLHCVQ TAFHILSGQG DVLNIDPLKF YTHLYKTLFK LHAGATNEGV 

       610        620        630        640        650        660 
EIVLQCLDVM LTKRRKQVSQ QRALAFIKRL CTLALHVLPN SSIGILATTR ILMHTFPKTD 

       670        680        690        700        710        720 
LLLDSESQGS GVFLPELDEP EYCNAQNTAL WELHALRRHY HPIVQRFAAH LIAGAPSEGS 

       730        740        750        760        770        780 
GALKPELSRR SATELFEAYS MAEMTFNPPV ESSNPKIKGK FLQGDSFLNE DLNQLIKRYS 

       790        800 
SEVATESPLD FTKYLKTSLH 

« Hide

References

« Hide 'large scale' references
[1]"Fad24, a mammalian homolog of Noc3p, is a positive regulator in adipocyte differentiation."
Tominaga K., Johmura Y., Nishizuka M., Imagawa M.
J. Cell Sci. 117:6217-6226(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[2]"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. expand/collapse author list , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Uterus.
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 318-800, VARIANT ALA-472.
Tissue: Hepatoma and Teratocarcinoma.
[5]"Functional proteomic analysis of human nucleolus."
Scherl A., Coute Y., Deon C., Calle A., Kindbeiter K., Sanchez J.-C., Greco A., Hochstrasser D.F., Diaz J.-J.
Mol. Biol. Cell 13:4100-4109(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[6]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-787, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[7]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-787, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[8]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-787, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB077992 mRNA. Translation: BAB84194.1.
AL355341 Genomic DNA. Translation: CAD13194.1.
BC049850 mRNA. Translation: AAH49850.1.
AK022882 mRNA. Translation: BAB14291.1. Different initiation.
AK026953 mRNA. Translation: BAB15599.1. Different initiation.
CCDSCCDS7433.1.
RefSeqNP_071896.8. NM_022451.9.
UniGeneHs.74899.

3D structure databases

ProteinModelPortalQ8WTT2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid122131. 6 interactions.
IntActQ8WTT2. 4 interactions.
MINTMINT-3046174.
STRING9606.ENSP00000360412.

PTM databases

PhosphoSiteQ8WTT2.

Polymorphism databases

DMDM74751495.

2D gel databases

SWISS-2DPAGEQ8WTT2.

Proteomic databases

MaxQBQ8WTT2.
PaxDbQ8WTT2.
PRIDEQ8WTT2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000371361; ENSP00000360412; ENSG00000173145.
GeneID64318.
KEGGhsa:64318.
UCSCuc001kjq.1. human.

Organism-specific databases

CTD64318.
GeneCardsGC10M096083.
H-InvDBHIX0035465.
HGNCHGNC:24034. NOC3L.
MIM610769. gene.
neXtProtNX_Q8WTT2.
PharmGKBPA134887727.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5117.
HOGENOMHOG000293323.
HOVERGENHBG082040.
InParanoidQ8WTT2.
KOK14834.
OrthoDBEOG71CFKH.
PhylomeDBQ8WTT2.
TreeFamTF318817.

Gene expression databases

ArrayExpressQ8WTT2.
BgeeQ8WTT2.
CleanExHS_NOC3L.
GenevestigatorQ8WTT2.

Family and domain databases

InterProIPR016024. ARM-type_fold.
IPR005612. CCAAT-binding_factor.
IPR011501. NOC3p.
IPR016903. Nucleolar_cplx-assoc_3.
[Graphical view]
PfamPF03914. CBF. 1 hit.
PF07540. NOC3p. 1 hit.
[Graphical view]
PIRSFPIRSF028977. Nucleolar_complex_p3. 1 hit.
SUPFAMSSF48371. SSF48371. 3 hits.
ProtoNetSearch...

Other

ChiTaRSNOC3L. human.
GenomeRNAi64318.
NextBio66225.
PROQ8WTT2.
SOURCESearch...

Entry information

Entry nameNOC3L_HUMAN
AccessionPrimary (citable) accession number: Q8WTT2
Secondary accession number(s): Q9H5M6, Q9H9D8
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: March 1, 2002
Last modified: July 9, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM