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Q8WTT0

- CLC4C_HUMAN

UniProt

Q8WTT0 - CLC4C_HUMAN

Protein

C-type lectin domain family 4 member C

Gene

CLEC4C

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Involved in antigen-capturing. Target ligand into antigen processing and peptide-loading compartments for presentation to T-cells. May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells. May act as a signaling receptor that activates protein-tyrosine kinases and mobilizes intracellular calcium. Does not seem to bind mannose.2 Publications

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro

    GO - Biological processi

    1. innate immune response Source: UniProtKB-KW

    Keywords - Biological processi

    Adaptive immunity, Immunity, Innate immunity

    Keywords - Ligandi

    Lectin

    Protein family/group databases

    MEROPSiI63.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-type lectin domain family 4 member C
    Alternative name(s):
    Blood dendritic cell antigen 2
    Short name:
    BDCA-2
    C-type lectin superfamily member 7
    Dendritic lectin
    CD_antigen: CD303
    Gene namesi
    Name:CLEC4C
    Synonyms:BDCA2, CLECSF11, CLECSF7, DLEC, HECL
    ORF Names:UNQ9361/PRO34150
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:13258. CLEC4C.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26585.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 213213C-type lectin domain family 4 member CPRO_0000046615Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi83 ↔ 94PROSITE-ProRule annotation
    Glycosylationi110 – 1101N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi111 ↔ 206PROSITE-ProRule annotation
    Glycosylationi137 – 1371N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi164 – 1641N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi180 ↔ 198PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8WTT0.
    PRIDEiQ8WTT0.

    Expressioni

    Tissue specificityi

    Expressed in plasmacytoid dendritic cells (PDCs). Constitutively expressed in immature monocyte-derived dendritic cells (iMDDC) and is significantly down-regulated upon maturation with LPS but not with TNF-alpha.3 Publications

    Gene expression databases

    ArrayExpressiQ8WTT0.
    BgeeiQ8WTT0.
    CleanExiHS_CLEC4C.
    GenevestigatoriQ8WTT0.

    Organism-specific databases

    HPAiHPA029432.

    Interactioni

    Protein-protein interaction databases

    BioGridi128012. 1 interaction.
    DIPiDIP-29513N.
    DIP-29515N.
    STRINGi9606.ENSP00000353500.

    Structurei

    Secondary structure

    1
    213
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi88 – 903
    Beta strandi93 – 975
    Helixi104 – 1129
    Turni113 – 1153
    Helixi124 – 1329
    Beta strandi140 – 1467
    Beta strandi154 – 1574
    Helixi163 – 1653
    Beta strandi179 – 1857
    Beta strandi191 – 1966
    Beta strandi202 – 2098

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3WBPX-ray1.80A/B83-210[»]
    3WBQX-ray2.30A/B83-210[»]
    3WBRX-ray2.20A/B/C/D/E/F/G/H83-210[»]
    ProteinModelPortaliQ8WTT0.
    SMRiQ8WTT0. Positions 83-209.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2121CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini45 – 213169ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei22 – 4423Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini90 – 207118C-type lectinPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 C-type lectin domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG240805.
    HOGENOMiHOG000059556.
    HOVERGENiHBG050992.
    InParanoidiQ8WTT0.
    KOiK06723.
    OMAiCKMKKIY.
    OrthoDBiEOG7CK36W.
    PhylomeDBiQ8WTT0.
    TreeFamiTF333341.

    Family and domain databases

    Gene3Di3.10.100.10. 1 hit.
    InterProiIPR001304. C-type_lectin.
    IPR016186. C-type_lectin-like.
    IPR018378. C-type_lectin_CS.
    IPR016187. C-type_lectin_fold.
    [Graphical view]
    PfamiPF00059. Lectin_C. 1 hit.
    [Graphical view]
    SMARTiSM00034. CLECT. 1 hit.
    [Graphical view]
    SUPFAMiSSF56436. SSF56436. 1 hit.
    PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
    PS50041. C_TYPE_LECTIN_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8WTT0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVPEEEPQDR EKGLWWFQLK VWSMAVVSIL LLSVCFTVSS VVPHNFMYSK    50
    TVKRLSKLRE YQQYHPSLTC VMEGKDIEDW SCCPTPWTSF QSSCYFISTG 100
    MQSWTKSQKN CSVMGADLVV INTREEQDFI IQNLKRNSSY FLGLSDPGGR 150
    RHWQWVDQTP YNENVTFWHS GEPNNLDERC AIINFRSSEE WGWNDIHCHV 200
    PQKSICKMKK IYI 213
    Length:213
    Mass (Da):25,038
    Last modified:March 1, 2002 - v1
    Checksum:i5DC82C95BE2378C1
    GO
    Isoform 2 (identifier: Q8WTT0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         11-41: Missing.

    Show »
    Length:182
    Mass (Da):21,498
    Checksum:i78EB4E4E0109E4E7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti66 – 661P → S in AAQ88590. (PubMed:12975309)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei11 – 4131Missing in isoform 2. 1 PublicationVSP_012845Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF325459 mRNA. Translation: AAL37358.1.
    AF325460 mRNA. Translation: AAL37359.1.
    AF293615 mRNA. Translation: AAL37036.1.
    AY358223 mRNA. Translation: AAQ88590.1.
    CH471116 Genomic DNA. Translation: EAW88655.1.
    CH471116 Genomic DNA. Translation: EAW88656.1.
    BC074967 mRNA. Translation: AAH74967.1.
    BC074968 mRNA. Translation: AAH74968.1.
    BC102015 mRNA. Translation: AAI02016.1.
    BC102016 mRNA. Translation: AAI02017.1.
    BC102017 mRNA. Translation: AAI02018.1.
    BC114338 mRNA. Translation: AAI14339.1.
    CCDSiCCDS8583.1. [Q8WTT0-1]
    CCDS8584.1. [Q8WTT0-2]
    RefSeqiNP_569708.1. NM_130441.2. [Q8WTT0-1]
    NP_987099.1. NM_203503.1. [Q8WTT0-2]
    UniGeneiHs.351812.

    Genome annotation databases

    EnsembliENST00000354629; ENSP00000346648; ENSG00000198178. [Q8WTT0-2]
    ENST00000360345; ENSP00000353500; ENSG00000198178. [Q8WTT0-1]
    ENST00000540085; ENSP00000445338; ENSG00000198178. [Q8WTT0-2]
    ENST00000542353; ENSP00000440428; ENSG00000198178. [Q8WTT0-1]
    GeneIDi170482.
    KEGGihsa:170482.
    UCSCiuc001qtg.1. human. [Q8WTT0-1]
    uc001qti.1. human. [Q8WTT0-2]

    Polymorphism databases

    DMDMi59797957.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Web resourcesi

    Functional Glycomics Gateway - Glycan Binding

    BDCA-2

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF325459 mRNA. Translation: AAL37358.1 .
    AF325460 mRNA. Translation: AAL37359.1 .
    AF293615 mRNA. Translation: AAL37036.1 .
    AY358223 mRNA. Translation: AAQ88590.1 .
    CH471116 Genomic DNA. Translation: EAW88655.1 .
    CH471116 Genomic DNA. Translation: EAW88656.1 .
    BC074967 mRNA. Translation: AAH74967.1 .
    BC074968 mRNA. Translation: AAH74968.1 .
    BC102015 mRNA. Translation: AAI02016.1 .
    BC102016 mRNA. Translation: AAI02017.1 .
    BC102017 mRNA. Translation: AAI02018.1 .
    BC114338 mRNA. Translation: AAI14339.1 .
    CCDSi CCDS8583.1. [Q8WTT0-1 ]
    CCDS8584.1. [Q8WTT0-2 ]
    RefSeqi NP_569708.1. NM_130441.2. [Q8WTT0-1 ]
    NP_987099.1. NM_203503.1. [Q8WTT0-2 ]
    UniGenei Hs.351812.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3WBP X-ray 1.80 A/B 83-210 [» ]
    3WBQ X-ray 2.30 A/B 83-210 [» ]
    3WBR X-ray 2.20 A/B/C/D/E/F/G/H 83-210 [» ]
    ProteinModelPortali Q8WTT0.
    SMRi Q8WTT0. Positions 83-209.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 128012. 1 interaction.
    DIPi DIP-29513N.
    DIP-29515N.
    STRINGi 9606.ENSP00000353500.

    Chemistry

    ChEMBLi CHEMBL2176855.

    Protein family/group databases

    MEROPSi I63.001.

    Polymorphism databases

    DMDMi 59797957.

    Proteomic databases

    PaxDbi Q8WTT0.
    PRIDEi Q8WTT0.

    Protocols and materials databases

    DNASUi 170482.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000354629 ; ENSP00000346648 ; ENSG00000198178 . [Q8WTT0-2 ]
    ENST00000360345 ; ENSP00000353500 ; ENSG00000198178 . [Q8WTT0-1 ]
    ENST00000540085 ; ENSP00000445338 ; ENSG00000198178 . [Q8WTT0-2 ]
    ENST00000542353 ; ENSP00000440428 ; ENSG00000198178 . [Q8WTT0-1 ]
    GeneIDi 170482.
    KEGGi hsa:170482.
    UCSCi uc001qtg.1. human. [Q8WTT0-1 ]
    uc001qti.1. human. [Q8WTT0-2 ]

    Organism-specific databases

    CTDi 170482.
    GeneCardsi GC12M007882.
    HGNCi HGNC:13258. CLEC4C.
    HPAi HPA029432.
    MIMi 606677. gene.
    neXtProti NX_Q8WTT0.
    PharmGKBi PA26585.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG240805.
    HOGENOMi HOG000059556.
    HOVERGENi HBG050992.
    InParanoidi Q8WTT0.
    KOi K06723.
    OMAi CKMKKIY.
    OrthoDBi EOG7CK36W.
    PhylomeDBi Q8WTT0.
    TreeFami TF333341.

    Miscellaneous databases

    GenomeRNAii 170482.
    NextBioi 88939.
    PROi Q8WTT0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8WTT0.
    Bgeei Q8WTT0.
    CleanExi HS_CLEC4C.
    Genevestigatori Q8WTT0.

    Family and domain databases

    Gene3Di 3.10.100.10. 1 hit.
    InterProi IPR001304. C-type_lectin.
    IPR016186. C-type_lectin-like.
    IPR018378. C-type_lectin_CS.
    IPR016187. C-type_lectin_fold.
    [Graphical view ]
    Pfami PF00059. Lectin_C. 1 hit.
    [Graphical view ]
    SMARTi SM00034. CLECT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56436. SSF56436. 1 hit.
    PROSITEi PS00615. C_TYPE_LECTIN_1. 1 hit.
    PS50041. C_TYPE_LECTIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular and genomic characterization of human DLEC, a novel member of the C-type lectin receptor gene family preferentially expressed on monocyte-derived dendritic cells."
      Arce I., Roda-Navarro P., Montoya M.C., Hernanz-Falcon P., Puig-Kroger A., Fernandez-Ruiz E.
      Eur. J. Immunol. 31:2733-2740(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
    2. "BDCA-2, a novel plasmacytoid dendritic cell-specific type II C-type lectin, mediates antigen capture and is a potent inhibitor of interferon alpha/beta induction."
      Dzionek A., Sohma Y., Nagafune J., Cella M., Colonna M., Facchetti F., Gunther G., Johnston I., Lanzavecchia A., Nagasaka T., Okada T., Vermi W., Winkels G., Yamamoto T., Zysk M., Yamaguchi Y., Schmitz J.
      J. Exp. Med. 194:1823-1834(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    6. "Identification and characterization of the gene for a novel C-type lectin (CLECSF7) that maps near the natural killer gene complex on human chromosome 12."
      Fernandes M.J., Iscove N.N., Gingras G., Calabretta B.
      Genomics 69:263-270(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiCLC4C_HUMAN
    AccessioniPrimary (citable) accession number: Q8WTT0
    Secondary accession number(s): D3DUU3
    , Q3T1C3, Q6UXS8, Q8WXX8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 15, 2005
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3