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Q8WTT0 (CLC4C_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-type lectin domain family 4 member C
Alternative name(s):
Blood dendritic cell antigen 2
Short name=BDCA-2
C-type lectin superfamily member 7
Dendritic lectin
CD_antigen=CD303
Gene names
Name:CLEC4C
Synonyms:BDCA2, CLECSF11, CLECSF7, DLEC, HECL
ORF Names:UNQ9361/PRO34150
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length213 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in antigen-capturing. Target ligand into antigen processing and peptide-loading compartments for presentation to T-cells. May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells. May act as a signaling receptor that activates protein-tyrosine kinases and mobilizes intracellular calcium. Does not seem to bind mannose. Ref.2 Ref.6

Subcellular location

Membrane; Single-pass type II membrane protein Probable.

Tissue specificity

Expressed in plasmacytoid dendritic cells (PDCs). Constitutively expressed in immature monocyte-derived dendritic cells (iMDDC) and is significantly down-regulated upon maturation with LPS but not with TNF-alpha. Ref.1 Ref.2 Ref.6

Sequence similarities

Contains 1 C-type lectin domain.

Ontologies

Keywords
   Biological processAdaptive immunity
Immunity
Innate immunity
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
   DomainSignal-anchor
Transmembrane
Transmembrane helix
   LigandLectin
   PTMDisulfide bond
Glycoprotein
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processinnate immune response

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functioncarbohydrate binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8WTT0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8WTT0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     11-41: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 213213C-type lectin domain family 4 member C
PRO_0000046615

Regions

Topological domain1 – 2121Cytoplasmic Potential
Transmembrane22 – 4423Helical; Signal-anchor for type II membrane protein; Potential
Topological domain45 – 213169Extracellular Potential
Domain90 – 207118C-type lectin

Amino acid modifications

Glycosylation1101N-linked (GlcNAc...) Potential
Glycosylation1371N-linked (GlcNAc...) Potential
Glycosylation1641N-linked (GlcNAc...) Potential
Disulfide bond83 ↔ 94 By similarity
Disulfide bond111 ↔ 206 By similarity
Disulfide bond180 ↔ 198 By similarity

Natural variations

Alternative sequence11 – 4131Missing in isoform 2.
VSP_012845

Experimental info

Sequence conflict661P → S in AAQ88590. Ref.3

Secondary structure

...................... 213
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: 5DC82C95BE2378C1

FASTA21325,038
        10         20         30         40         50         60 
MVPEEEPQDR EKGLWWFQLK VWSMAVVSIL LLSVCFTVSS VVPHNFMYSK TVKRLSKLRE 

        70         80         90        100        110        120 
YQQYHPSLTC VMEGKDIEDW SCCPTPWTSF QSSCYFISTG MQSWTKSQKN CSVMGADLVV 

       130        140        150        160        170        180 
INTREEQDFI IQNLKRNSSY FLGLSDPGGR RHWQWVDQTP YNENVTFWHS GEPNNLDERC 

       190        200        210 
AIINFRSSEE WGWNDIHCHV PQKSICKMKK IYI 

« Hide

Isoform 2 [UniParc].

Checksum: 78EB4E4E0109E4E7
Show »

FASTA18221,498

References

« Hide 'large scale' references
[1]"Molecular and genomic characterization of human DLEC, a novel member of the C-type lectin receptor gene family preferentially expressed on monocyte-derived dendritic cells."
Arce I., Roda-Navarro P., Montoya M.C., Hernanz-Falcon P., Puig-Kroger A., Fernandez-Ruiz E.
Eur. J. Immunol. 31:2733-2740(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
[2]"BDCA-2, a novel plasmacytoid dendritic cell-specific type II C-type lectin, mediates antigen capture and is a potent inhibitor of interferon alpha/beta induction."
Dzionek A., Sohma Y., Nagafune J., Cella M., Colonna M., Facchetti F., Gunther G., Johnston I., Lanzavecchia A., Nagasaka T., Okada T., Vermi W., Winkels G., Yamamoto T., Zysk M., Yamaguchi Y., Schmitz J.
J. Exp. Med. 194:1823-1834(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
[3]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[6]"Identification and characterization of the gene for a novel C-type lectin (CLECSF7) that maps near the natural killer gene complex on human chromosome 12."
Fernandes M.J., Iscove N.N., Gingras G., Calabretta B.
Genomics 69:263-270(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF325459 mRNA. Translation: AAL37358.1.
AF325460 mRNA. Translation: AAL37359.1.
AF293615 mRNA. Translation: AAL37036.1.
AY358223 mRNA. Translation: AAQ88590.1.
CH471116 Genomic DNA. Translation: EAW88655.1.
CH471116 Genomic DNA. Translation: EAW88656.1.
BC074967 mRNA. Translation: AAH74967.1.
BC074968 mRNA. Translation: AAH74968.1.
BC102015 mRNA. Translation: AAI02016.1.
BC102016 mRNA. Translation: AAI02017.1.
BC102017 mRNA. Translation: AAI02018.1.
BC114338 mRNA. Translation: AAI14339.1.
CCDSCCDS8583.1. [Q8WTT0-1]
CCDS8584.1. [Q8WTT0-2]
RefSeqNP_569708.1. NM_130441.2. [Q8WTT0-1]
NP_987099.1. NM_203503.1. [Q8WTT0-2]
UniGeneHs.351812.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3WBPX-ray1.80A/B83-210[»]
3WBQX-ray2.30A/B83-210[»]
3WBRX-ray2.20A/B/C/D/E/F/G/H83-210[»]
ProteinModelPortalQ8WTT0.
SMRQ8WTT0. Positions 83-209.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid128012. 1 interaction.
DIPDIP-29513N.
DIP-29515N.
STRING9606.ENSP00000353500.

Chemistry

ChEMBLCHEMBL2176855.

Protein family/group databases

MEROPSI63.001.

Polymorphism databases

DMDM59797957.

Proteomic databases

PaxDbQ8WTT0.
PRIDEQ8WTT0.

Protocols and materials databases

DNASU170482.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000354629; ENSP00000346648; ENSG00000198178. [Q8WTT0-2]
ENST00000360345; ENSP00000353500; ENSG00000198178. [Q8WTT0-1]
ENST00000540085; ENSP00000445338; ENSG00000198178. [Q8WTT0-2]
ENST00000542353; ENSP00000440428; ENSG00000198178. [Q8WTT0-1]
GeneID170482.
KEGGhsa:170482.
UCSCuc001qtg.1. human. [Q8WTT0-1]
uc001qti.1. human. [Q8WTT0-2]

Organism-specific databases

CTD170482.
GeneCardsGC12M007882.
HGNCHGNC:13258. CLEC4C.
HPAHPA029432.
MIM606677. gene.
neXtProtNX_Q8WTT0.
PharmGKBPA26585.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG240805.
HOGENOMHOG000059556.
HOVERGENHBG050992.
InParanoidQ8WTT0.
KOK06723.
OMACKMKKIY.
OrthoDBEOG7CK36W.
PhylomeDBQ8WTT0.
TreeFamTF333341.

Gene expression databases

ArrayExpressQ8WTT0.
BgeeQ8WTT0.
CleanExHS_CLEC4C.
GenevestigatorQ8WTT0.

Family and domain databases

Gene3D3.10.100.10. 1 hit.
InterProIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMSSF56436. SSF56436. 1 hit.
PROSITEPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi170482.
NextBio88939.
PROQ8WTT0.
SOURCESearch...

Entry information

Entry nameCLC4C_HUMAN
AccessionPrimary (citable) accession number: Q8WTT0
Secondary accession number(s): D3DUU3 expand/collapse secondary AC list , Q3T1C3, Q6UXS8, Q8WXX8
Entry history
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: March 1, 2002
Last modified: July 9, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries