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Q8WTT0

- CLC4C_HUMAN

UniProt

Q8WTT0 - CLC4C_HUMAN

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Protein
C-type lectin domain family 4 member C
Gene
CLEC4C, BDCA2, CLECSF11, CLECSF7, DLEC, HECL, UNQ9361/PRO34150
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in antigen-capturing. Target ligand into antigen processing and peptide-loading compartments for presentation to T-cells. May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells. May act as a signaling receptor that activates protein-tyrosine kinases and mobilizes intracellular calcium. Does not seem to bind mannose.2 Publications

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. innate immune response Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Adaptive immunity, Immunity, Innate immunity

Keywords - Ligandi

Lectin

Protein family/group databases

MEROPSiI63.001.

Names & Taxonomyi

Protein namesi
Recommended name:
C-type lectin domain family 4 member C
Alternative name(s):
Blood dendritic cell antigen 2
Short name:
BDCA-2
C-type lectin superfamily member 7
Dendritic lectin
CD_antigen: CD303
Gene namesi
Name:CLEC4C
Synonyms:BDCA2, CLECSF11, CLECSF7, DLEC, HECL
ORF Names:UNQ9361/PRO34150
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:13258. CLEC4C.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2121Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei22 – 4423Helical; Signal-anchor for type II membrane protein; Reviewed prediction
Add
BLAST
Topological domaini45 – 213169Extracellular Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26585.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 213213C-type lectin domain family 4 member C
PRO_0000046615Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi83 ↔ 94 By similarity
Glycosylationi110 – 1101N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi111 ↔ 206 By similarity
Glycosylationi137 – 1371N-linked (GlcNAc...) Reviewed prediction
Glycosylationi164 – 1641N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi180 ↔ 198 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8WTT0.
PRIDEiQ8WTT0.

Expressioni

Tissue specificityi

Expressed in plasmacytoid dendritic cells (PDCs). Constitutively expressed in immature monocyte-derived dendritic cells (iMDDC) and is significantly down-regulated upon maturation with LPS but not with TNF-alpha.3 Publications

Gene expression databases

ArrayExpressiQ8WTT0.
BgeeiQ8WTT0.
CleanExiHS_CLEC4C.
GenevestigatoriQ8WTT0.

Organism-specific databases

HPAiHPA029432.

Interactioni

Protein-protein interaction databases

BioGridi128012. 1 interaction.
DIPiDIP-29513N.
DIP-29515N.
STRINGi9606.ENSP00000353500.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi88 – 903
Beta strandi93 – 975
Helixi104 – 1129
Turni113 – 1153
Helixi124 – 1329
Beta strandi140 – 1467
Beta strandi154 – 1574
Helixi163 – 1653
Beta strandi179 – 1857
Beta strandi191 – 1966
Beta strandi202 – 2098

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3WBPX-ray1.80A/B83-210[»]
3WBQX-ray2.30A/B83-210[»]
3WBRX-ray2.20A/B/C/D/E/F/G/H83-210[»]
ProteinModelPortaliQ8WTT0.
SMRiQ8WTT0. Positions 83-209.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini90 – 207118C-type lectin
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG240805.
HOGENOMiHOG000059556.
HOVERGENiHBG050992.
InParanoidiQ8WTT0.
KOiK06723.
OMAiCKMKKIY.
OrthoDBiEOG7CK36W.
PhylomeDBiQ8WTT0.
TreeFamiTF333341.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8WTT0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MVPEEEPQDR EKGLWWFQLK VWSMAVVSIL LLSVCFTVSS VVPHNFMYSK    50
TVKRLSKLRE YQQYHPSLTC VMEGKDIEDW SCCPTPWTSF QSSCYFISTG 100
MQSWTKSQKN CSVMGADLVV INTREEQDFI IQNLKRNSSY FLGLSDPGGR 150
RHWQWVDQTP YNENVTFWHS GEPNNLDERC AIINFRSSEE WGWNDIHCHV 200
PQKSICKMKK IYI 213
Length:213
Mass (Da):25,038
Last modified:March 1, 2002 - v1
Checksum:i5DC82C95BE2378C1
GO
Isoform 2 (identifier: Q8WTT0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     11-41: Missing.

Show »
Length:182
Mass (Da):21,498
Checksum:i78EB4E4E0109E4E7
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei11 – 4131Missing in isoform 2.
VSP_012845Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti66 – 661P → S in AAQ88590. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF325459 mRNA. Translation: AAL37358.1.
AF325460 mRNA. Translation: AAL37359.1.
AF293615 mRNA. Translation: AAL37036.1.
AY358223 mRNA. Translation: AAQ88590.1.
CH471116 Genomic DNA. Translation: EAW88655.1.
CH471116 Genomic DNA. Translation: EAW88656.1.
BC074967 mRNA. Translation: AAH74967.1.
BC074968 mRNA. Translation: AAH74968.1.
BC102015 mRNA. Translation: AAI02016.1.
BC102016 mRNA. Translation: AAI02017.1.
BC102017 mRNA. Translation: AAI02018.1.
BC114338 mRNA. Translation: AAI14339.1.
CCDSiCCDS8583.1. [Q8WTT0-1]
CCDS8584.1. [Q8WTT0-2]
RefSeqiNP_569708.1. NM_130441.2. [Q8WTT0-1]
NP_987099.1. NM_203503.1. [Q8WTT0-2]
UniGeneiHs.351812.

Genome annotation databases

EnsembliENST00000354629; ENSP00000346648; ENSG00000198178. [Q8WTT0-2]
ENST00000360345; ENSP00000353500; ENSG00000198178. [Q8WTT0-1]
ENST00000540085; ENSP00000445338; ENSG00000198178. [Q8WTT0-2]
ENST00000542353; ENSP00000440428; ENSG00000198178. [Q8WTT0-1]
GeneIDi170482.
KEGGihsa:170482.
UCSCiuc001qtg.1. human. [Q8WTT0-1]
uc001qti.1. human. [Q8WTT0-2]

Polymorphism databases

DMDMi59797957.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

BDCA-2

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF325459 mRNA. Translation: AAL37358.1 .
AF325460 mRNA. Translation: AAL37359.1 .
AF293615 mRNA. Translation: AAL37036.1 .
AY358223 mRNA. Translation: AAQ88590.1 .
CH471116 Genomic DNA. Translation: EAW88655.1 .
CH471116 Genomic DNA. Translation: EAW88656.1 .
BC074967 mRNA. Translation: AAH74967.1 .
BC074968 mRNA. Translation: AAH74968.1 .
BC102015 mRNA. Translation: AAI02016.1 .
BC102016 mRNA. Translation: AAI02017.1 .
BC102017 mRNA. Translation: AAI02018.1 .
BC114338 mRNA. Translation: AAI14339.1 .
CCDSi CCDS8583.1. [Q8WTT0-1 ]
CCDS8584.1. [Q8WTT0-2 ]
RefSeqi NP_569708.1. NM_130441.2. [Q8WTT0-1 ]
NP_987099.1. NM_203503.1. [Q8WTT0-2 ]
UniGenei Hs.351812.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3WBP X-ray 1.80 A/B 83-210 [» ]
3WBQ X-ray 2.30 A/B 83-210 [» ]
3WBR X-ray 2.20 A/B/C/D/E/F/G/H 83-210 [» ]
ProteinModelPortali Q8WTT0.
SMRi Q8WTT0. Positions 83-209.
ModBasei Search...

Protein-protein interaction databases

BioGridi 128012. 1 interaction.
DIPi DIP-29513N.
DIP-29515N.
STRINGi 9606.ENSP00000353500.

Chemistry

ChEMBLi CHEMBL2176855.

Protein family/group databases

MEROPSi I63.001.

Polymorphism databases

DMDMi 59797957.

Proteomic databases

PaxDbi Q8WTT0.
PRIDEi Q8WTT0.

Protocols and materials databases

DNASUi 170482.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000354629 ; ENSP00000346648 ; ENSG00000198178 . [Q8WTT0-2 ]
ENST00000360345 ; ENSP00000353500 ; ENSG00000198178 . [Q8WTT0-1 ]
ENST00000540085 ; ENSP00000445338 ; ENSG00000198178 . [Q8WTT0-2 ]
ENST00000542353 ; ENSP00000440428 ; ENSG00000198178 . [Q8WTT0-1 ]
GeneIDi 170482.
KEGGi hsa:170482.
UCSCi uc001qtg.1. human. [Q8WTT0-1 ]
uc001qti.1. human. [Q8WTT0-2 ]

Organism-specific databases

CTDi 170482.
GeneCardsi GC12M007882.
HGNCi HGNC:13258. CLEC4C.
HPAi HPA029432.
MIMi 606677. gene.
neXtProti NX_Q8WTT0.
PharmGKBi PA26585.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG240805.
HOGENOMi HOG000059556.
HOVERGENi HBG050992.
InParanoidi Q8WTT0.
KOi K06723.
OMAi CKMKKIY.
OrthoDBi EOG7CK36W.
PhylomeDBi Q8WTT0.
TreeFami TF333341.

Miscellaneous databases

GenomeRNAii 170482.
NextBioi 88939.
PROi Q8WTT0.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8WTT0.
Bgeei Q8WTT0.
CleanExi HS_CLEC4C.
Genevestigatori Q8WTT0.

Family and domain databases

Gene3Di 3.10.100.10. 1 hit.
InterProi IPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
[Graphical view ]
Pfami PF00059. Lectin_C. 1 hit.
[Graphical view ]
SMARTi SM00034. CLECT. 1 hit.
[Graphical view ]
SUPFAMi SSF56436. SSF56436. 1 hit.
PROSITEi PS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular and genomic characterization of human DLEC, a novel member of the C-type lectin receptor gene family preferentially expressed on monocyte-derived dendritic cells."
    Arce I., Roda-Navarro P., Montoya M.C., Hernanz-Falcon P., Puig-Kroger A., Fernandez-Ruiz E.
    Eur. J. Immunol. 31:2733-2740(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY.
  2. "BDCA-2, a novel plasmacytoid dendritic cell-specific type II C-type lectin, mediates antigen capture and is a potent inhibitor of interferon alpha/beta induction."
    Dzionek A., Sohma Y., Nagafune J., Cella M., Colonna M., Facchetti F., Gunther G., Johnston I., Lanzavecchia A., Nagasaka T., Okada T., Vermi W., Winkels G., Yamamoto T., Zysk M., Yamaguchi Y., Schmitz J.
    J. Exp. Med. 194:1823-1834(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  6. "Identification and characterization of the gene for a novel C-type lectin (CLECSF7) that maps near the natural killer gene complex on human chromosome 12."
    Fernandes M.J., Iscove N.N., Gingras G., Calabretta B.
    Genomics 69:263-270(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiCLC4C_HUMAN
AccessioniPrimary (citable) accession number: Q8WTT0
Secondary accession number(s): D3DUU3
, Q3T1C3, Q6UXS8, Q8WXX8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: March 1, 2002
Last modified: July 9, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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