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Protein

C-type lectin domain family 4 member C

Gene

CLEC4C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in antigen-capturing. Target ligand into antigen processing and peptide-loading compartments for presentation to T-cells. May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells. May act as a signaling receptor that activates protein-tyrosine kinases and mobilizes intracellular calcium. Does not seem to bind mannose.2 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Adaptive immunity, Immunity, Innate immunity

Keywords - Ligandi

Lectin

Enzyme and pathway databases

BioCyciZFISH:G66-32185-MONOMER.
ReactomeiR-HSA-5621480. Dectin-2 family.
R-HSA-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
C-type lectin domain family 4 member C
Alternative name(s):
Blood dendritic cell antigen 2
Short name:
BDCA-2
C-type lectin superfamily member 7
Dendritic lectin
CD_antigen: CD303
Gene namesi
Name:CLEC4C
Synonyms:BDCA2, CLECSF11, CLECSF7, DLEC, HECL
ORF Names:UNQ9361/PRO34150
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:13258. CLEC4C.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 21CytoplasmicSequence analysisAdd BLAST21
Transmembranei22 – 44Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST23
Topological domaini45 – 213ExtracellularSequence analysisAdd BLAST169

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi170482.
OpenTargetsiENSG00000198178.
PharmGKBiPA26585.

Chemistry databases

ChEMBLiCHEMBL2176855.

Polymorphism and mutation databases

BioMutaiCLEC4C.
DMDMi59797957.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000466151 – 213C-type lectin domain family 4 member CAdd BLAST213

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi83 ↔ 94PROSITE-ProRule annotation
Glycosylationi110N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi111 ↔ 206PROSITE-ProRule annotation
Glycosylationi137N-linked (GlcNAc...)Sequence analysis1
Glycosylationi164N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi180 ↔ 198PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8WTT0.
PRIDEiQ8WTT0.

Expressioni

Tissue specificityi

Expressed in plasmacytoid dendritic cells (PDCs). Constitutively expressed in immature monocyte-derived dendritic cells (iMDDC) and is significantly down-regulated upon maturation with LPS but not with TNF-alpha.3 Publications

Gene expression databases

BgeeiENSG00000198178.
CleanExiHS_CLEC4C.
ExpressionAtlasiQ8WTT0. baseline and differential.
GenevisibleiQ8WTT0. HS.

Organism-specific databases

HPAiHPA029432.

Interactioni

Protein-protein interaction databases

BioGridi128012. 1 interactor.
DIPiDIP-29513N.
DIP-29515N.
STRINGi9606.ENSP00000353500.

Chemistry databases

BindingDBiQ8WTT0.

Structurei

Secondary structure

1213
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi68 – 73Combined sources6
Beta strandi80 – 84Combined sources5
Beta strandi87 – 90Combined sources4
Beta strandi93 – 102Combined sources10
Helixi104 – 113Combined sources10
Helixi124 – 130Combined sources7
Helixi131 – 133Combined sources3
Beta strandi140 – 145Combined sources6
Beta strandi149 – 151Combined sources3
Beta strandi154 – 157Combined sources4
Helixi163 – 165Combined sources3
Beta strandi180 – 186Combined sources7
Turni187 – 189Combined sources3
Beta strandi190 – 196Combined sources7
Beta strandi202 – 209Combined sources8
Beta strandi211 – 213Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3WBPX-ray1.80A/B83-210[»]
3WBQX-ray2.30A/B83-210[»]
3WBRX-ray2.20A/B/C/D/E/F/G/H83-210[»]
4ZESX-ray1.65A/B67-213[»]
4ZETX-ray2.90A/B67-213[»]
ProteinModelPortaliQ8WTT0.
SMRiQ8WTT0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini90 – 207C-type lectinPROSITE-ProRule annotationAdd BLAST118

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IS2V. Eukaryota.
ENOG410ZBWX. LUCA.
GeneTreeiENSGT00760000118924.
HOGENOMiHOG000059556.
HOVERGENiHBG050992.
InParanoidiQ8WTT0.
KOiK06723.
OMAiCAIINFR.
OrthoDBiEOG091G0HG1.
PhylomeDBiQ8WTT0.
TreeFamiTF333341.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR018378. C-type_lectin_CS.
IPR016187. CTDL_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WTT0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVPEEEPQDR EKGLWWFQLK VWSMAVVSIL LLSVCFTVSS VVPHNFMYSK
60 70 80 90 100
TVKRLSKLRE YQQYHPSLTC VMEGKDIEDW SCCPTPWTSF QSSCYFISTG
110 120 130 140 150
MQSWTKSQKN CSVMGADLVV INTREEQDFI IQNLKRNSSY FLGLSDPGGR
160 170 180 190 200
RHWQWVDQTP YNENVTFWHS GEPNNLDERC AIINFRSSEE WGWNDIHCHV
210
PQKSICKMKK IYI
Length:213
Mass (Da):25,038
Last modified:March 1, 2002 - v1
Checksum:i5DC82C95BE2378C1
GO
Isoform 2 (identifier: Q8WTT0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     11-41: Missing.

Show »
Length:182
Mass (Da):21,498
Checksum:i78EB4E4E0109E4E7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti66P → S in AAQ88590 (PubMed:12975309).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01284511 – 41Missing in isoform 2. 1 PublicationAdd BLAST31

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF325459 mRNA. Translation: AAL37358.1.
AF325460 mRNA. Translation: AAL37359.1.
AF293615 mRNA. Translation: AAL37036.1.
AY358223 mRNA. Translation: AAQ88590.1.
CH471116 Genomic DNA. Translation: EAW88655.1.
CH471116 Genomic DNA. Translation: EAW88656.1.
BC074967 mRNA. Translation: AAH74967.1.
BC074968 mRNA. Translation: AAH74968.1.
BC102015 mRNA. Translation: AAI02016.1.
BC102016 mRNA. Translation: AAI02017.1.
BC102017 mRNA. Translation: AAI02018.1.
BC114338 mRNA. Translation: AAI14339.1.
CCDSiCCDS8583.1. [Q8WTT0-1]
CCDS8584.1. [Q8WTT0-2]
RefSeqiNP_569708.1. NM_130441.2. [Q8WTT0-1]
NP_987099.1. NM_203503.1. [Q8WTT0-2]
UniGeneiHs.351812.

Genome annotation databases

EnsembliENST00000354629; ENSP00000346648; ENSG00000198178. [Q8WTT0-2]
ENST00000360345; ENSP00000353500; ENSG00000198178. [Q8WTT0-1]
ENST00000540085; ENSP00000445338; ENSG00000198178. [Q8WTT0-2]
ENST00000542353; ENSP00000440428; ENSG00000198178. [Q8WTT0-1]
GeneIDi170482.
KEGGihsa:170482.
UCSCiuc001qtg.2. human. [Q8WTT0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

BDCA-2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF325459 mRNA. Translation: AAL37358.1.
AF325460 mRNA. Translation: AAL37359.1.
AF293615 mRNA. Translation: AAL37036.1.
AY358223 mRNA. Translation: AAQ88590.1.
CH471116 Genomic DNA. Translation: EAW88655.1.
CH471116 Genomic DNA. Translation: EAW88656.1.
BC074967 mRNA. Translation: AAH74967.1.
BC074968 mRNA. Translation: AAH74968.1.
BC102015 mRNA. Translation: AAI02016.1.
BC102016 mRNA. Translation: AAI02017.1.
BC102017 mRNA. Translation: AAI02018.1.
BC114338 mRNA. Translation: AAI14339.1.
CCDSiCCDS8583.1. [Q8WTT0-1]
CCDS8584.1. [Q8WTT0-2]
RefSeqiNP_569708.1. NM_130441.2. [Q8WTT0-1]
NP_987099.1. NM_203503.1. [Q8WTT0-2]
UniGeneiHs.351812.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3WBPX-ray1.80A/B83-210[»]
3WBQX-ray2.30A/B83-210[»]
3WBRX-ray2.20A/B/C/D/E/F/G/H83-210[»]
4ZESX-ray1.65A/B67-213[»]
4ZETX-ray2.90A/B67-213[»]
ProteinModelPortaliQ8WTT0.
SMRiQ8WTT0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128012. 1 interactor.
DIPiDIP-29513N.
DIP-29515N.
STRINGi9606.ENSP00000353500.

Chemistry databases

BindingDBiQ8WTT0.
ChEMBLiCHEMBL2176855.

Polymorphism and mutation databases

BioMutaiCLEC4C.
DMDMi59797957.

Proteomic databases

PaxDbiQ8WTT0.
PRIDEiQ8WTT0.

Protocols and materials databases

DNASUi170482.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354629; ENSP00000346648; ENSG00000198178. [Q8WTT0-2]
ENST00000360345; ENSP00000353500; ENSG00000198178. [Q8WTT0-1]
ENST00000540085; ENSP00000445338; ENSG00000198178. [Q8WTT0-2]
ENST00000542353; ENSP00000440428; ENSG00000198178. [Q8WTT0-1]
GeneIDi170482.
KEGGihsa:170482.
UCSCiuc001qtg.2. human. [Q8WTT0-1]

Organism-specific databases

CTDi170482.
DisGeNETi170482.
GeneCardsiCLEC4C.
HGNCiHGNC:13258. CLEC4C.
HPAiHPA029432.
MIMi606677. gene.
neXtProtiNX_Q8WTT0.
OpenTargetsiENSG00000198178.
PharmGKBiPA26585.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IS2V. Eukaryota.
ENOG410ZBWX. LUCA.
GeneTreeiENSGT00760000118924.
HOGENOMiHOG000059556.
HOVERGENiHBG050992.
InParanoidiQ8WTT0.
KOiK06723.
OMAiCAIINFR.
OrthoDBiEOG091G0HG1.
PhylomeDBiQ8WTT0.
TreeFamiTF333341.

Enzyme and pathway databases

BioCyciZFISH:G66-32185-MONOMER.
ReactomeiR-HSA-5621480. Dectin-2 family.
R-HSA-6798695. Neutrophil degranulation.

Miscellaneous databases

GenomeRNAii170482.
PROiQ8WTT0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198178.
CleanExiHS_CLEC4C.
ExpressionAtlasiQ8WTT0. baseline and differential.
GenevisibleiQ8WTT0. HS.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR018378. C-type_lectin_CS.
IPR016187. CTDL_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCLC4C_HUMAN
AccessioniPrimary (citable) accession number: Q8WTT0
Secondary accession number(s): D3DUU3
, Q3T1C3, Q6UXS8, Q8WXX8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: March 1, 2002
Last modified: November 30, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.