ID   NET5_HUMAN              Reviewed;         489 AA.
AC   Q8WTR8; Q8N4X9; Q8WU63;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 2.
DT   27-MAR-2024, entry version 159.
DE   RecName: Full=Netrin-5;
DE   AltName: Full=Netrin-1-like protein;
DE   Flags: Precursor;
GN   Name=NTN5;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Muscle;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Plays a role in neurogenesis. Prevents motor neuron cell body
CC       migration out of the neural tube. {ECO:0000250|UniProtKB:Q3UQ22}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000255}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q8WTR8-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8WTR8-2; Sequence=VSP_031667, VSP_031668;
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DR   EMBL; CH471177; EAW52386.1; -; Genomic_DNA.
DR   EMBL; CH471177; EAW52387.1; -; Genomic_DNA.
DR   EMBL; BC018654; AAH18654.2; -; mRNA.
DR   EMBL; BC018697; AAH18697.2; -; mRNA.
DR   EMBL; BC021210; AAH21210.2; -; mRNA.
DR   EMBL; BC033207; AAH33207.1; -; mRNA.
DR   CCDS; CCDS33068.1; -. [Q8WTR8-1]
DR   RefSeq; NP_665806.1; NM_145807.2. [Q8WTR8-1]
DR   AlphaFoldDB; Q8WTR8; -.
DR   SMR; Q8WTR8; -.
DR   BioGRID; 125960; 23.
DR   STRING; 9606.ENSP00000270235; -.
DR   GlyCosmos; Q8WTR8; 1 site, No reported glycans.
DR   GlyGen; Q8WTR8; 1 site.
DR   PhosphoSitePlus; Q8WTR8; -.
DR   BioMuta; NTN5; -.
DR   DMDM; 74730628; -.
DR   MassIVE; Q8WTR8; -.
DR   PaxDb; 9606-ENSP00000270235; -.
DR   PeptideAtlas; Q8WTR8; -.
DR   ProteomicsDB; 74592; -. [Q8WTR8-1]
DR   ProteomicsDB; 74593; -. [Q8WTR8-2]
DR   Antibodypedia; 31764; 68 antibodies from 14 providers.
DR   DNASU; 126147; -.
DR   Ensembl; ENST00000270235.11; ENSP00000270235.4; ENSG00000142233.14. [Q8WTR8-1]
DR   GeneID; 126147; -.
DR   KEGG; hsa:126147; -.
DR   MANE-Select; ENST00000270235.11; ENSP00000270235.4; NM_145807.4; NP_665806.1.
DR   UCSC; uc002pkb.3; human. [Q8WTR8-1]
DR   AGR; HGNC:25208; -.
DR   CTD; 126147; -.
DR   DisGeNET; 126147; -.
DR   GeneCards; NTN5; -.
DR   HGNC; HGNC:25208; NTN5.
DR   HPA; ENSG00000142233; Tissue enhanced (pituitary).
DR   neXtProt; NX_Q8WTR8; -.
DR   OpenTargets; ENSG00000142233; -.
DR   PharmGKB; PA164724232; -.
DR   VEuPathDB; HostDB:ENSG00000142233; -.
DR   eggNOG; KOG3512; Eukaryota.
DR   GeneTree; ENSGT00940000161874; -.
DR   HOGENOM; CLU_018213_0_0_1; -.
DR   InParanoid; Q8WTR8; -.
DR   OMA; QTSGQCT; -.
DR   OrthoDB; 2916807at2759; -.
DR   PhylomeDB; Q8WTR8; -.
DR   TreeFam; TF352481; -.
DR   PathwayCommons; Q8WTR8; -.
DR   SignaLink; Q8WTR8; -.
DR   BioGRID-ORCS; 126147; 16 hits in 1143 CRISPR screens.
DR   GenomeRNAi; 126147; -.
DR   Pharos; Q8WTR8; Tdark.
DR   PRO; PR:Q8WTR8; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; Q8WTR8; Protein.
DR   Bgee; ENSG00000142233; Expressed in right uterine tube and 93 other cell types or tissues.
DR   ExpressionAtlas; Q8WTR8; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0022008; P:neurogenesis; ISS:UniProtKB.
DR   CDD; cd00055; EGF_Lam; 2.
DR   CDD; cd03579; NTR_netrin-1_like; 1.
DR   Gene3D; 2.40.50.120; -; 1.
DR   Gene3D; 2.10.25.10; Laminin; 1.
DR   Gene3D; 2.170.300.10; Tie2 ligand-binding domain superfamily; 1.
DR   InterPro; IPR002049; LE_dom.
DR   InterPro; IPR001134; Netrin_domain.
DR   InterPro; IPR018933; Netrin_module_non-TIMP.
DR   InterPro; IPR008993; TIMP-like_OB-fold.
DR   PANTHER; PTHR10574:SF435; LAMININ SUBUNIT GAMMA-1; 1.
DR   PANTHER; PTHR10574; NETRIN/LAMININ-RELATED; 1.
DR   Pfam; PF00053; Laminin_EGF; 3.
DR   Pfam; PF01759; NTR; 1.
DR   SMART; SM00643; C345C; 1.
DR   SMART; SM00180; EGF_Lam; 3.
DR   SUPFAM; SSF57196; EGF/Laminin; 3.
DR   SUPFAM; SSF50242; TIMP-like; 1.
DR   PROSITE; PS00022; EGF_1; 2.
DR   PROSITE; PS01248; EGF_LAM_1; 2.
DR   PROSITE; PS50027; EGF_LAM_2; 3.
DR   PROSITE; PS50189; NTR; 1.
DR   Genevisible; Q8WTR8; HS.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Developmental protein; Disulfide bond; Glycoprotein;
KW   Laminin EGF-like domain; Neurogenesis; Reference proteome; Repeat;
KW   Secreted; Signal.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000255"
FT   CHAIN           17..489
FT                   /note="Netrin-5"
FT                   /id="PRO_0000320575"
FT   DOMAIN          157..211
FT                   /note="Laminin EGF-like 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00460"
FT   DOMAIN          212..274
FT                   /note="Laminin EGF-like 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00460"
FT   DOMAIN          275..324
FT                   /note="Laminin EGF-like 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00460"
FT   DOMAIN          345..475
FT                   /note="NTR"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00295"
FT   REGION          470..489
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        62
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        157..166
FT                   /evidence="ECO:0000250"
FT   DISULFID        159..175
FT                   /evidence="ECO:0000250"
FT   DISULFID        177..186
FT                   /evidence="ECO:0000250"
FT   DISULFID        189..209
FT                   /evidence="ECO:0000250"
FT   DISULFID        212..221
FT                   /evidence="ECO:0000250"
FT   DISULFID        214..239
FT                   /evidence="ECO:0000250"
FT   DISULFID        242..251
FT                   /evidence="ECO:0000250"
FT   DISULFID        254..272
FT                   /evidence="ECO:0000250"
FT   DISULFID        275..287
FT                   /evidence="ECO:0000250"
FT   DISULFID        277..294
FT                   /evidence="ECO:0000250"
FT   DISULFID        296..305
FT                   /evidence="ECO:0000250"
FT   DISULFID        308..322
FT                   /evidence="ECO:0000250"
FT   DISULFID        345..418
FT                   /evidence="ECO:0000250"
FT   DISULFID        349..420
FT                   /evidence="ECO:0000250"
FT   DISULFID        364..475
FT                   /evidence="ECO:0000250"
FT   VAR_SEQ         342..350
FT                   /note="DPQCQNYCN -> GKTVWHGGP (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_031667"
FT   VAR_SEQ         351..489
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_031668"
SQ   SEQUENCE   489 AA;  53174 MW;  3438D41FA45F8B3E CRC64;
     MPVTFALLLL LGQATADPCY DPQGRPQFCL PPVTQLAAVA ASCPQACALS PGNHLGARET
     CNGSLTLALG GPFLLTSVSL RFCTPGPPAL ILSAAWASGG PWRLLWHRPA WPGALGGPER
     VTFHSTPGPK ATVAASHLRV EFGGQAGLAA AGLRGRCQCH GHAARCAARA RPPRCHCRHH
     TTGPGCESCR PSHRDWPWRP ATPRHPHPCL PCSCNQHARR CRFNSELFRL SGGRSGGVCE
     RCRHHTAGRH CHYCQPGFWR DPSQPIFSRR ACRACQCHPI GATGGTCNQT SGQCTCKLGV
     TGLTCNRCGP GYQQSRSPRM PCQRIPEATT TLATTPGAYS SDPQCQNYCN MSDTRVHMSL
     RRYCQQDHVL RAQVLASEAA GPAWQRLAVR VLAVYKQRAQ PVRRGDQDAW VPRADLTCGC
     LRLQPGTDYL LLGSAVGDPD PTRLILDRHG LALPWRPRWA RPLKRLQQEE RAGGCRGVRA
     PTPSPRPEH
//