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Q8WTR8

- NET5_HUMAN

UniProt

Q8WTR8 - NET5_HUMAN

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Protein
Netrin-5
Gene
NTN5
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Netrin-5
Alternative name(s):
Netrin-1-like protein
Gene namesi
Name:NTN5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:25208. NTN5.

Subcellular locationi

Secreted Reviewed prediction

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164724232.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616 Reviewed prediction
Add
BLAST
Chaini17 – 489473Netrin-5
PRO_0000320575Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi62 – 621N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi157 ↔ 166 By similarity
Disulfide bondi159 ↔ 175 By similarity
Disulfide bondi177 ↔ 186 By similarity
Disulfide bondi189 ↔ 209 By similarity
Disulfide bondi212 ↔ 221 By similarity
Disulfide bondi214 ↔ 239 By similarity
Disulfide bondi242 ↔ 251 By similarity
Disulfide bondi254 ↔ 272 By similarity
Disulfide bondi275 ↔ 287 By similarity
Disulfide bondi277 ↔ 294 By similarity
Disulfide bondi296 ↔ 305 By similarity
Disulfide bondi308 ↔ 322 By similarity
Disulfide bondi345 ↔ 418 By similarity
Disulfide bondi349 ↔ 420 By similarity
Disulfide bondi364 ↔ 475 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8WTR8.
PRIDEiQ8WTR8.

Expressioni

Gene expression databases

ArrayExpressiQ8WTR8.
BgeeiQ8WTR8.
GenevestigatoriQ8WTR8.

Interactioni

Protein-protein interaction databases

MINTiMINT-4723142.

Structurei

3D structure databases

ProteinModelPortaliQ8WTR8.
SMRiQ8WTR8. Positions 116-349.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini157 – 21155Laminin EGF-like 1
Add
BLAST
Domaini212 – 27463Laminin EGF-like 2
Add
BLAST
Domaini275 – 32450Laminin EGF-like 3
Add
BLAST
Domaini345 – 475131NTR
Add
BLAST

Sequence similaritiesi

Contains 1 NTR domain.

Keywords - Domaini

Laminin EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiNOG327968.
HOGENOMiHOG000286017.
HOVERGENiHBG096704.
InParanoidiQ8WTR8.
OMAiYSSDPQC.
OrthoDBiEOG7XM2XH.
PhylomeDBiQ8WTR8.
TreeFamiTF352481.

Family and domain databases

InterProiIPR002049. EGF_laminin.
IPR001134. Netrin_domain.
IPR018933. Netrin_module_non-TIMP.
IPR008993. TIMP-like_OB-fold.
[Graphical view]
PfamiPF00053. Laminin_EGF. 3 hits.
PF01759. NTR. 1 hit.
[Graphical view]
SMARTiSM00643. C345C. 1 hit.
SM00180. EGF_Lam. 3 hits.
[Graphical view]
SUPFAMiSSF50242. SSF50242. 1 hit.
PROSITEiPS00022. EGF_1. 2 hits.
PS01248. EGF_LAM_1. 2 hits.
PS50027. EGF_LAM_2. 3 hits.
PS50189. NTR. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8WTR8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MPVTFALLLL LGQATADPCY DPQGRPQFCL PPVTQLAAVA ASCPQACALS    50
PGNHLGARET CNGSLTLALG GPFLLTSVSL RFCTPGPPAL ILSAAWASGG 100
PWRLLWHRPA WPGALGGPER VTFHSTPGPK ATVAASHLRV EFGGQAGLAA 150
AGLRGRCQCH GHAARCAARA RPPRCHCRHH TTGPGCESCR PSHRDWPWRP 200
ATPRHPHPCL PCSCNQHARR CRFNSELFRL SGGRSGGVCE RCRHHTAGRH 250
CHYCQPGFWR DPSQPIFSRR ACRACQCHPI GATGGTCNQT SGQCTCKLGV 300
TGLTCNRCGP GYQQSRSPRM PCQRIPEATT TLATTPGAYS SDPQCQNYCN 350
MSDTRVHMSL RRYCQQDHVL RAQVLASEAA GPAWQRLAVR VLAVYKQRAQ 400
PVRRGDQDAW VPRADLTCGC LRLQPGTDYL LLGSAVGDPD PTRLILDRHG 450
LALPWRPRWA RPLKRLQQEE RAGGCRGVRA PTPSPRPEH 489
Length:489
Mass (Da):53,174
Last modified:July 5, 2004 - v2
Checksum:i3438D41FA45F8B3E
GO
Isoform 2 (identifier: Q8WTR8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     342-350: DPQCQNYCN → GKTVWHGGP
     351-489: Missing.

Show »
Length:350
Mass (Da):37,332
Checksum:iB1EF4C481F587A0C
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei342 – 3509DPQCQNYCN → GKTVWHGGP in isoform 2.
VSP_031667
Alternative sequencei351 – 489139Missing in isoform 2.
VSP_031668Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH471177 Genomic DNA. Translation: EAW52386.1.
CH471177 Genomic DNA. Translation: EAW52387.1.
BC018654 mRNA. Translation: AAH18654.2.
BC018697 mRNA. Translation: AAH18697.2.
BC021210 mRNA. Translation: AAH21210.2.
BC033207 mRNA. Translation: AAH33207.1.
CCDSiCCDS33068.1. [Q8WTR8-1]
RefSeqiNP_665806.1. NM_145807.1. [Q8WTR8-1]
XP_006723074.1. XM_006723011.1. [Q8WTR8-1]
UniGeneiHs.326217.

Genome annotation databases

EnsembliENST00000270235; ENSP00000270235; ENSG00000142233. [Q8WTR8-1]
GeneIDi126147.
KEGGihsa:126147.
UCSCiuc002pkb.3. human. [Q8WTR8-1]
uc002pkc.3. human. [Q8WTR8-2]

Polymorphism databases

DMDMi74730628.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH471177 Genomic DNA. Translation: EAW52386.1 .
CH471177 Genomic DNA. Translation: EAW52387.1 .
BC018654 mRNA. Translation: AAH18654.2 .
BC018697 mRNA. Translation: AAH18697.2 .
BC021210 mRNA. Translation: AAH21210.2 .
BC033207 mRNA. Translation: AAH33207.1 .
CCDSi CCDS33068.1. [Q8WTR8-1 ]
RefSeqi NP_665806.1. NM_145807.1. [Q8WTR8-1 ]
XP_006723074.1. XM_006723011.1. [Q8WTR8-1 ]
UniGenei Hs.326217.

3D structure databases

ProteinModelPortali Q8WTR8.
SMRi Q8WTR8. Positions 116-349.
ModBasei Search...

Protein-protein interaction databases

MINTi MINT-4723142.

Polymorphism databases

DMDMi 74730628.

Proteomic databases

PaxDbi Q8WTR8.
PRIDEi Q8WTR8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000270235 ; ENSP00000270235 ; ENSG00000142233 . [Q8WTR8-1 ]
GeneIDi 126147.
KEGGi hsa:126147.
UCSCi uc002pkb.3. human. [Q8WTR8-1 ]
uc002pkc.3. human. [Q8WTR8-2 ]

Organism-specific databases

CTDi 126147.
GeneCardsi GC19M049164.
HGNCi HGNC:25208. NTN5.
neXtProti NX_Q8WTR8.
PharmGKBi PA164724232.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG327968.
HOGENOMi HOG000286017.
HOVERGENi HBG096704.
InParanoidi Q8WTR8.
OMAi YSSDPQC.
OrthoDBi EOG7XM2XH.
PhylomeDBi Q8WTR8.
TreeFami TF352481.

Miscellaneous databases

GenomeRNAii 126147.
NextBioi 81704.
PROi Q8WTR8.

Gene expression databases

ArrayExpressi Q8WTR8.
Bgeei Q8WTR8.
Genevestigatori Q8WTR8.

Family and domain databases

InterProi IPR002049. EGF_laminin.
IPR001134. Netrin_domain.
IPR018933. Netrin_module_non-TIMP.
IPR008993. TIMP-like_OB-fold.
[Graphical view ]
Pfami PF00053. Laminin_EGF. 3 hits.
PF01759. NTR. 1 hit.
[Graphical view ]
SMARTi SM00643. C345C. 1 hit.
SM00180. EGF_Lam. 3 hits.
[Graphical view ]
SUPFAMi SSF50242. SSF50242. 1 hit.
PROSITEi PS00022. EGF_1. 2 hits.
PS01248. EGF_LAM_1. 2 hits.
PS50027. EGF_LAM_2. 3 hits.
PS50189. NTR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Muscle.

Entry informationi

Entry nameiNET5_HUMAN
AccessioniPrimary (citable) accession number: Q8WTR8
Secondary accession number(s): Q8N4X9, Q8WU63
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi