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Q8WTR8

- NET5_HUMAN

UniProt

Q8WTR8 - NET5_HUMAN

Protein

Netrin-5

Gene

NTN5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 2 (05 Jul 2004)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Netrin-5
    Alternative name(s):
    Netrin-1-like protein
    Gene namesi
    Name:NTN5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:25208. NTN5.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA164724232.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1616Sequence AnalysisAdd
    BLAST
    Chaini17 – 489473Netrin-5PRO_0000320575Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi62 – 621N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi157 ↔ 166By similarity
    Disulfide bondi159 ↔ 175By similarity
    Disulfide bondi177 ↔ 186By similarity
    Disulfide bondi189 ↔ 209By similarity
    Disulfide bondi212 ↔ 221By similarity
    Disulfide bondi214 ↔ 239By similarity
    Disulfide bondi242 ↔ 251By similarity
    Disulfide bondi254 ↔ 272By similarity
    Disulfide bondi275 ↔ 287By similarity
    Disulfide bondi277 ↔ 294By similarity
    Disulfide bondi296 ↔ 305By similarity
    Disulfide bondi308 ↔ 322By similarity
    Disulfide bondi345 ↔ 418By similarity
    Disulfide bondi349 ↔ 420By similarity
    Disulfide bondi364 ↔ 475By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8WTR8.
    PRIDEiQ8WTR8.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8WTR8.
    BgeeiQ8WTR8.
    GenevestigatoriQ8WTR8.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-4723142.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8WTR8.
    SMRiQ8WTR8. Positions 116-349.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini157 – 21155Laminin EGF-like 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini212 – 27463Laminin EGF-like 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini275 – 32450Laminin EGF-like 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini345 – 475131NTRPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 3 laminin EGF-like domains.PROSITE-ProRule annotation
    Contains 1 NTR domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Laminin EGF-like domain, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG327968.
    HOGENOMiHOG000286017.
    HOVERGENiHBG096704.
    InParanoidiQ8WTR8.
    OMAiYSSDPQC.
    OrthoDBiEOG7XM2XH.
    PhylomeDBiQ8WTR8.
    TreeFamiTF352481.

    Family and domain databases

    InterProiIPR002049. EGF_laminin.
    IPR001134. Netrin_domain.
    IPR018933. Netrin_module_non-TIMP.
    IPR008993. TIMP-like_OB-fold.
    [Graphical view]
    PfamiPF00053. Laminin_EGF. 3 hits.
    PF01759. NTR. 1 hit.
    [Graphical view]
    SMARTiSM00643. C345C. 1 hit.
    SM00180. EGF_Lam. 3 hits.
    [Graphical view]
    SUPFAMiSSF50242. SSF50242. 1 hit.
    PROSITEiPS00022. EGF_1. 2 hits.
    PS01248. EGF_LAM_1. 2 hits.
    PS50027. EGF_LAM_2. 3 hits.
    PS50189. NTR. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8WTR8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPVTFALLLL LGQATADPCY DPQGRPQFCL PPVTQLAAVA ASCPQACALS    50
    PGNHLGARET CNGSLTLALG GPFLLTSVSL RFCTPGPPAL ILSAAWASGG 100
    PWRLLWHRPA WPGALGGPER VTFHSTPGPK ATVAASHLRV EFGGQAGLAA 150
    AGLRGRCQCH GHAARCAARA RPPRCHCRHH TTGPGCESCR PSHRDWPWRP 200
    ATPRHPHPCL PCSCNQHARR CRFNSELFRL SGGRSGGVCE RCRHHTAGRH 250
    CHYCQPGFWR DPSQPIFSRR ACRACQCHPI GATGGTCNQT SGQCTCKLGV 300
    TGLTCNRCGP GYQQSRSPRM PCQRIPEATT TLATTPGAYS SDPQCQNYCN 350
    MSDTRVHMSL RRYCQQDHVL RAQVLASEAA GPAWQRLAVR VLAVYKQRAQ 400
    PVRRGDQDAW VPRADLTCGC LRLQPGTDYL LLGSAVGDPD PTRLILDRHG 450
    LALPWRPRWA RPLKRLQQEE RAGGCRGVRA PTPSPRPEH 489
    Length:489
    Mass (Da):53,174
    Last modified:July 5, 2004 - v2
    Checksum:i3438D41FA45F8B3E
    GO
    Isoform 2 (identifier: Q8WTR8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         342-350: DPQCQNYCN → GKTVWHGGP
         351-489: Missing.

    Show »
    Length:350
    Mass (Da):37,332
    Checksum:iB1EF4C481F587A0C
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei342 – 3509DPQCQNYCN → GKTVWHGGP in isoform 2. 1 PublicationVSP_031667
    Alternative sequencei351 – 489139Missing in isoform 2. 1 PublicationVSP_031668Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH471177 Genomic DNA. Translation: EAW52386.1.
    CH471177 Genomic DNA. Translation: EAW52387.1.
    BC018654 mRNA. Translation: AAH18654.2.
    BC018697 mRNA. Translation: AAH18697.2.
    BC021210 mRNA. Translation: AAH21210.2.
    BC033207 mRNA. Translation: AAH33207.1.
    CCDSiCCDS33068.1. [Q8WTR8-1]
    RefSeqiNP_665806.1. NM_145807.1. [Q8WTR8-1]
    XP_006723074.1. XM_006723011.1. [Q8WTR8-1]
    UniGeneiHs.326217.

    Genome annotation databases

    EnsembliENST00000270235; ENSP00000270235; ENSG00000142233. [Q8WTR8-1]
    GeneIDi126147.
    KEGGihsa:126147.
    UCSCiuc002pkb.3. human. [Q8WTR8-1]
    uc002pkc.3. human. [Q8WTR8-2]

    Polymorphism databases

    DMDMi74730628.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH471177 Genomic DNA. Translation: EAW52386.1 .
    CH471177 Genomic DNA. Translation: EAW52387.1 .
    BC018654 mRNA. Translation: AAH18654.2 .
    BC018697 mRNA. Translation: AAH18697.2 .
    BC021210 mRNA. Translation: AAH21210.2 .
    BC033207 mRNA. Translation: AAH33207.1 .
    CCDSi CCDS33068.1. [Q8WTR8-1 ]
    RefSeqi NP_665806.1. NM_145807.1. [Q8WTR8-1 ]
    XP_006723074.1. XM_006723011.1. [Q8WTR8-1 ]
    UniGenei Hs.326217.

    3D structure databases

    ProteinModelPortali Q8WTR8.
    SMRi Q8WTR8. Positions 116-349.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4723142.

    Polymorphism databases

    DMDMi 74730628.

    Proteomic databases

    PaxDbi Q8WTR8.
    PRIDEi Q8WTR8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000270235 ; ENSP00000270235 ; ENSG00000142233 . [Q8WTR8-1 ]
    GeneIDi 126147.
    KEGGi hsa:126147.
    UCSCi uc002pkb.3. human. [Q8WTR8-1 ]
    uc002pkc.3. human. [Q8WTR8-2 ]

    Organism-specific databases

    CTDi 126147.
    GeneCardsi GC19M049164.
    HGNCi HGNC:25208. NTN5.
    neXtProti NX_Q8WTR8.
    PharmGKBi PA164724232.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG327968.
    HOGENOMi HOG000286017.
    HOVERGENi HBG096704.
    InParanoidi Q8WTR8.
    OMAi YSSDPQC.
    OrthoDBi EOG7XM2XH.
    PhylomeDBi Q8WTR8.
    TreeFami TF352481.

    Miscellaneous databases

    GenomeRNAii 126147.
    NextBioi 81704.
    PROi Q8WTR8.

    Gene expression databases

    ArrayExpressi Q8WTR8.
    Bgeei Q8WTR8.
    Genevestigatori Q8WTR8.

    Family and domain databases

    InterProi IPR002049. EGF_laminin.
    IPR001134. Netrin_domain.
    IPR018933. Netrin_module_non-TIMP.
    IPR008993. TIMP-like_OB-fold.
    [Graphical view ]
    Pfami PF00053. Laminin_EGF. 3 hits.
    PF01759. NTR. 1 hit.
    [Graphical view ]
    SMARTi SM00643. C345C. 1 hit.
    SM00180. EGF_Lam. 3 hits.
    [Graphical view ]
    SUPFAMi SSF50242. SSF50242. 1 hit.
    PROSITEi PS00022. EGF_1. 2 hits.
    PS01248. EGF_LAM_1. 2 hits.
    PS50027. EGF_LAM_2. 3 hits.
    PS50189. NTR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Muscle.

    Entry informationi

    Entry nameiNET5_HUMAN
    AccessioniPrimary (citable) accession number: Q8WTR8
    Secondary accession number(s): Q8N4X9, Q8WU63
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 26, 2008
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 97 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3