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Q8WTR8 (NET5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Netrin-5
Alternative name(s):
Netrin-1-like protein
Gene names
Name:NTN5
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length489 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Secreted Potential.

Sequence similarities

Contains 3 laminin EGF-like domains.

Contains 1 NTR domain.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityAlternative splicing
   DomainLaminin EGF-like domain
Repeat
Signal
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8WTR8-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8WTR8-2)

The sequence of this isoform differs from the canonical sequence as follows:
     342-350: DPQCQNYCN → GKTVWHGGP
     351-489: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1616 Potential
Chain17 – 489473Netrin-5
PRO_0000320575

Regions

Domain157 – 21155Laminin EGF-like 1
Domain212 – 27463Laminin EGF-like 2
Domain275 – 32450Laminin EGF-like 3
Domain345 – 475131NTR

Amino acid modifications

Glycosylation621N-linked (GlcNAc...) Potential
Disulfide bond157 ↔ 166 By similarity
Disulfide bond159 ↔ 175 By similarity
Disulfide bond177 ↔ 186 By similarity
Disulfide bond189 ↔ 209 By similarity
Disulfide bond212 ↔ 221 By similarity
Disulfide bond214 ↔ 239 By similarity
Disulfide bond242 ↔ 251 By similarity
Disulfide bond254 ↔ 272 By similarity
Disulfide bond275 ↔ 287 By similarity
Disulfide bond277 ↔ 294 By similarity
Disulfide bond296 ↔ 305 By similarity
Disulfide bond308 ↔ 322 By similarity
Disulfide bond345 ↔ 418 By similarity
Disulfide bond349 ↔ 420 By similarity
Disulfide bond364 ↔ 475 By similarity

Natural variations

Alternative sequence342 – 3509DPQCQNYCN → GKTVWHGGP in isoform 2.
VSP_031667
Alternative sequence351 – 489139Missing in isoform 2.
VSP_031668

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 5, 2004. Version 2.
Checksum: 3438D41FA45F8B3E

FASTA48953,174
        10         20         30         40         50         60 
MPVTFALLLL LGQATADPCY DPQGRPQFCL PPVTQLAAVA ASCPQACALS PGNHLGARET 

        70         80         90        100        110        120 
CNGSLTLALG GPFLLTSVSL RFCTPGPPAL ILSAAWASGG PWRLLWHRPA WPGALGGPER 

       130        140        150        160        170        180 
VTFHSTPGPK ATVAASHLRV EFGGQAGLAA AGLRGRCQCH GHAARCAARA RPPRCHCRHH 

       190        200        210        220        230        240 
TTGPGCESCR PSHRDWPWRP ATPRHPHPCL PCSCNQHARR CRFNSELFRL SGGRSGGVCE 

       250        260        270        280        290        300 
RCRHHTAGRH CHYCQPGFWR DPSQPIFSRR ACRACQCHPI GATGGTCNQT SGQCTCKLGV 

       310        320        330        340        350        360 
TGLTCNRCGP GYQQSRSPRM PCQRIPEATT TLATTPGAYS SDPQCQNYCN MSDTRVHMSL 

       370        380        390        400        410        420 
RRYCQQDHVL RAQVLASEAA GPAWQRLAVR VLAVYKQRAQ PVRRGDQDAW VPRADLTCGC 

       430        440        450        460        470        480 
LRLQPGTDYL LLGSAVGDPD PTRLILDRHG LALPWRPRWA RPLKRLQQEE RAGGCRGVRA 


PTPSPRPEH 

« Hide

Isoform 2 [UniParc].

Checksum: B1EF4C481F587A0C
Show »

FASTA35037,332

References

[1]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Muscle.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH471177 Genomic DNA. Translation: EAW52386.1.
CH471177 Genomic DNA. Translation: EAW52387.1.
BC018654 mRNA. Translation: AAH18654.2.
BC018697 mRNA. Translation: AAH18697.2.
BC021210 mRNA. Translation: AAH21210.2.
BC033207 mRNA. Translation: AAH33207.1.
CCDSCCDS33068.1. [Q8WTR8-1]
RefSeqNP_665806.1. NM_145807.1. [Q8WTR8-1]
XP_006723074.1. XM_006723011.1. [Q8WTR8-1]
UniGeneHs.326217.

3D structure databases

ProteinModelPortalQ8WTR8.
SMRQ8WTR8. Positions 116-349.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-4723142.

Polymorphism databases

DMDM74730628.

Proteomic databases

PaxDbQ8WTR8.
PRIDEQ8WTR8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000270235; ENSP00000270235; ENSG00000142233. [Q8WTR8-1]
GeneID126147.
KEGGhsa:126147.
UCSCuc002pkb.3. human. [Q8WTR8-1]
uc002pkc.3. human. [Q8WTR8-2]

Organism-specific databases

CTD126147.
GeneCardsGC19M049164.
HGNCHGNC:25208. NTN5.
neXtProtNX_Q8WTR8.
PharmGKBPA164724232.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG327968.
HOGENOMHOG000286017.
HOVERGENHBG096704.
InParanoidQ8WTR8.
OMAYSSDPQC.
OrthoDBEOG7XM2XH.
PhylomeDBQ8WTR8.
TreeFamTF352481.

Gene expression databases

ArrayExpressQ8WTR8.
BgeeQ8WTR8.
GenevestigatorQ8WTR8.

Family and domain databases

InterProIPR002049. EGF_laminin.
IPR001134. Netrin_domain.
IPR018933. Netrin_module_non-TIMP.
IPR008993. TIMP-like_OB-fold.
[Graphical view]
PfamPF00053. Laminin_EGF. 3 hits.
PF01759. NTR. 1 hit.
[Graphical view]
SMARTSM00643. C345C. 1 hit.
SM00180. EGF_Lam. 3 hits.
[Graphical view]
SUPFAMSSF50242. SSF50242. 1 hit.
PROSITEPS00022. EGF_1. 2 hits.
PS01248. EGF_LAM_1. 2 hits.
PS50027. EGF_LAM_2. 3 hits.
PS50189. NTR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi126147.
NextBio81704.
PROQ8WTR8.

Entry information

Entry nameNET5_HUMAN
AccessionPrimary (citable) accession number: Q8WTR8
Secondary accession number(s): Q8N4X9, Q8WU63
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM