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Protein

Netrin-5

Gene

NTN5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Netrin-5
Alternative name(s):
Netrin-1-like protein
Gene namesi
Name:NTN5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000142233.11
HGNCiHGNC:25208 NTN5
neXtProtiNX_Q8WTR8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000142233
PharmGKBiPA164724232

Polymorphism and mutation databases

BioMutaiNTN5
DMDMi74730628

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000032057517 – 489Netrin-5Add BLAST473

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi62N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi157 ↔ 166By similarity
Disulfide bondi159 ↔ 175By similarity
Disulfide bondi177 ↔ 186By similarity
Disulfide bondi189 ↔ 209By similarity
Disulfide bondi212 ↔ 221By similarity
Disulfide bondi214 ↔ 239By similarity
Disulfide bondi242 ↔ 251By similarity
Disulfide bondi254 ↔ 272By similarity
Disulfide bondi275 ↔ 287By similarity
Disulfide bondi277 ↔ 294By similarity
Disulfide bondi296 ↔ 305By similarity
Disulfide bondi308 ↔ 322By similarity
Disulfide bondi345 ↔ 418By similarity
Disulfide bondi349 ↔ 420By similarity
Disulfide bondi364 ↔ 475By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8WTR8
PRIDEiQ8WTR8
ProteomicsDBi74592
74593 [Q8WTR8-2]

PTM databases

PhosphoSitePlusiQ8WTR8

Expressioni

Gene expression databases

BgeeiENSG00000142233
ExpressionAtlasiQ8WTR8 baseline and differential
GenevisibleiQ8WTR8 HS

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000270235

Structurei

3D structure databases

ProteinModelPortaliQ8WTR8
SMRiQ8WTR8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini157 – 211Laminin EGF-like 1PROSITE-ProRule annotationAdd BLAST55
Domaini212 – 274Laminin EGF-like 2PROSITE-ProRule annotationAdd BLAST63
Domaini275 – 324Laminin EGF-like 3PROSITE-ProRule annotationAdd BLAST50
Domaini345 – 475NTRPROSITE-ProRule annotationAdd BLAST131

Keywords - Domaini

Laminin EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiKOG3512 Eukaryota
ENOG410XS7U LUCA
GeneTreeiENSGT00890000139348
HOGENOMiHOG000286017
HOVERGENiHBG096704
InParanoidiQ8WTR8
OMAiCRFNSEL
OrthoDBiEOG091G14PW
PhylomeDBiQ8WTR8
TreeFamiTF352481

Family and domain databases

InterProiView protein in InterPro
IPR002049 Laminin_EGF
IPR001134 Netrin_domain
IPR018933 Netrin_module_non-TIMP
IPR008993 TIMP-like_OB-fold
PfamiView protein in Pfam
PF00053 Laminin_EGF, 3 hits
PF01759 NTR, 1 hit
SMARTiView protein in SMART
SM00643 C345C, 1 hit
SM00180 EGF_Lam, 3 hits
SUPFAMiSSF50242 SSF50242, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 2 hits
PS01248 EGF_LAM_1, 2 hits
PS50027 EGF_LAM_2, 3 hits
PS50189 NTR, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WTR8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPVTFALLLL LGQATADPCY DPQGRPQFCL PPVTQLAAVA ASCPQACALS
60 70 80 90 100
PGNHLGARET CNGSLTLALG GPFLLTSVSL RFCTPGPPAL ILSAAWASGG
110 120 130 140 150
PWRLLWHRPA WPGALGGPER VTFHSTPGPK ATVAASHLRV EFGGQAGLAA
160 170 180 190 200
AGLRGRCQCH GHAARCAARA RPPRCHCRHH TTGPGCESCR PSHRDWPWRP
210 220 230 240 250
ATPRHPHPCL PCSCNQHARR CRFNSELFRL SGGRSGGVCE RCRHHTAGRH
260 270 280 290 300
CHYCQPGFWR DPSQPIFSRR ACRACQCHPI GATGGTCNQT SGQCTCKLGV
310 320 330 340 350
TGLTCNRCGP GYQQSRSPRM PCQRIPEATT TLATTPGAYS SDPQCQNYCN
360 370 380 390 400
MSDTRVHMSL RRYCQQDHVL RAQVLASEAA GPAWQRLAVR VLAVYKQRAQ
410 420 430 440 450
PVRRGDQDAW VPRADLTCGC LRLQPGTDYL LLGSAVGDPD PTRLILDRHG
460 470 480
LALPWRPRWA RPLKRLQQEE RAGGCRGVRA PTPSPRPEH
Length:489
Mass (Da):53,174
Last modified:July 5, 2004 - v2
Checksum:i3438D41FA45F8B3E
GO
Isoform 2 (identifier: Q8WTR8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     342-350: DPQCQNYCN → GKTVWHGGP
     351-489: Missing.

Show »
Length:350
Mass (Da):37,332
Checksum:iB1EF4C481F587A0C
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_031667342 – 350DPQCQNYCN → GKTVWHGGP in isoform 2. 1 Publication9
Alternative sequenceiVSP_031668351 – 489Missing in isoform 2. 1 PublicationAdd BLAST139

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471177 Genomic DNA Translation: EAW52386.1
CH471177 Genomic DNA Translation: EAW52387.1
BC018654 mRNA Translation: AAH18654.2
BC018697 mRNA Translation: AAH18697.2
BC021210 mRNA Translation: AAH21210.2
BC033207 mRNA Translation: AAH33207.1
CCDSiCCDS33068.1 [Q8WTR8-1]
RefSeqiNP_665806.1, NM_145807.2 [Q8WTR8-1]
UniGeneiHs.326217

Genome annotation databases

EnsembliENST00000270235; ENSP00000270235; ENSG00000142233 [Q8WTR8-1]
GeneIDi126147
KEGGihsa:126147
UCSCiuc002pkb.3 human [Q8WTR8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiNET5_HUMAN
AccessioniPrimary (citable) accession number: Q8WTR8
Secondary accession number(s): Q8N4X9, Q8WU63
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 5, 2004
Last modified: June 20, 2018
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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