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Protein

Netrin-5

Gene

NTN5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Netrin-5
Alternative name(s):
Netrin-1-like protein
Gene namesi
Name:NTN5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:25208. NTN5.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164724232.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence AnalysisAdd
BLAST
Chaini17 – 489473Netrin-5PRO_0000320575Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi62 – 621N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi157 ↔ 166By similarity
Disulfide bondi159 ↔ 175By similarity
Disulfide bondi177 ↔ 186By similarity
Disulfide bondi189 ↔ 209By similarity
Disulfide bondi212 ↔ 221By similarity
Disulfide bondi214 ↔ 239By similarity
Disulfide bondi242 ↔ 251By similarity
Disulfide bondi254 ↔ 272By similarity
Disulfide bondi275 ↔ 287By similarity
Disulfide bondi277 ↔ 294By similarity
Disulfide bondi296 ↔ 305By similarity
Disulfide bondi308 ↔ 322By similarity
Disulfide bondi345 ↔ 418By similarity
Disulfide bondi349 ↔ 420By similarity
Disulfide bondi364 ↔ 475By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8WTR8.
PRIDEiQ8WTR8.

Expressioni

Gene expression databases

BgeeiQ8WTR8.
ExpressionAtlasiQ8WTR8. baseline and differential.
GenevestigatoriQ8WTR8.

Interactioni

Protein-protein interaction databases

MINTiMINT-4723142.

Structurei

3D structure databases

ProteinModelPortaliQ8WTR8.
SMRiQ8WTR8. Positions 16-349.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini157 – 21155Laminin EGF-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini212 – 27463Laminin EGF-like 2PROSITE-ProRule annotationAdd
BLAST
Domaini275 – 32450Laminin EGF-like 3PROSITE-ProRule annotationAdd
BLAST
Domaini345 – 475131NTRPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 3 laminin EGF-like domains.PROSITE-ProRule annotation
Contains 1 NTR domain.PROSITE-ProRule annotation

Keywords - Domaini

Laminin EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiNOG327968.
GeneTreeiENSGT00780000121873.
HOGENOMiHOG000286017.
HOVERGENiHBG096704.
InParanoidiQ8WTR8.
OMAiYSSDPQC.
OrthoDBiEOG7XM2XH.
PhylomeDBiQ8WTR8.
TreeFamiTF352481.

Family and domain databases

InterProiIPR002049. EGF_laminin.
IPR001134. Netrin_domain.
IPR018933. Netrin_module_non-TIMP.
IPR008993. TIMP-like_OB-fold.
[Graphical view]
PfamiPF00053. Laminin_EGF. 3 hits.
PF01759. NTR. 1 hit.
[Graphical view]
SMARTiSM00643. C345C. 1 hit.
SM00180. EGF_Lam. 3 hits.
[Graphical view]
SUPFAMiSSF50242. SSF50242. 1 hit.
PROSITEiPS00022. EGF_1. 2 hits.
PS01248. EGF_LAM_1. 2 hits.
PS50027. EGF_LAM_2. 3 hits.
PS50189. NTR. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WTR8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPVTFALLLL LGQATADPCY DPQGRPQFCL PPVTQLAAVA ASCPQACALS
60 70 80 90 100
PGNHLGARET CNGSLTLALG GPFLLTSVSL RFCTPGPPAL ILSAAWASGG
110 120 130 140 150
PWRLLWHRPA WPGALGGPER VTFHSTPGPK ATVAASHLRV EFGGQAGLAA
160 170 180 190 200
AGLRGRCQCH GHAARCAARA RPPRCHCRHH TTGPGCESCR PSHRDWPWRP
210 220 230 240 250
ATPRHPHPCL PCSCNQHARR CRFNSELFRL SGGRSGGVCE RCRHHTAGRH
260 270 280 290 300
CHYCQPGFWR DPSQPIFSRR ACRACQCHPI GATGGTCNQT SGQCTCKLGV
310 320 330 340 350
TGLTCNRCGP GYQQSRSPRM PCQRIPEATT TLATTPGAYS SDPQCQNYCN
360 370 380 390 400
MSDTRVHMSL RRYCQQDHVL RAQVLASEAA GPAWQRLAVR VLAVYKQRAQ
410 420 430 440 450
PVRRGDQDAW VPRADLTCGC LRLQPGTDYL LLGSAVGDPD PTRLILDRHG
460 470 480
LALPWRPRWA RPLKRLQQEE RAGGCRGVRA PTPSPRPEH
Length:489
Mass (Da):53,174
Last modified:July 4, 2004 - v2
Checksum:i3438D41FA45F8B3E
GO
Isoform 2 (identifier: Q8WTR8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     342-350: DPQCQNYCN → GKTVWHGGP
     351-489: Missing.

Show »
Length:350
Mass (Da):37,332
Checksum:iB1EF4C481F587A0C
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei342 – 3509DPQCQNYCN → GKTVWHGGP in isoform 2. 1 PublicationVSP_031667
Alternative sequencei351 – 489139Missing in isoform 2. 1 PublicationVSP_031668Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471177 Genomic DNA. Translation: EAW52386.1.
CH471177 Genomic DNA. Translation: EAW52387.1.
BC018654 mRNA. Translation: AAH18654.2.
BC018697 mRNA. Translation: AAH18697.2.
BC021210 mRNA. Translation: AAH21210.2.
BC033207 mRNA. Translation: AAH33207.1.
CCDSiCCDS33068.1. [Q8WTR8-1]
RefSeqiNP_665806.1. NM_145807.2. [Q8WTR8-1]
XP_006723074.1. XM_006723011.1. [Q8WTR8-1]
UniGeneiHs.326217.

Genome annotation databases

EnsembliENST00000270235; ENSP00000270235; ENSG00000142233. [Q8WTR8-1]
GeneIDi126147.
KEGGihsa:126147.
UCSCiuc002pkb.3. human. [Q8WTR8-1]
uc002pkc.3. human. [Q8WTR8-2]

Polymorphism databases

DMDMi74730628.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH471177 Genomic DNA. Translation: EAW52386.1.
CH471177 Genomic DNA. Translation: EAW52387.1.
BC018654 mRNA. Translation: AAH18654.2.
BC018697 mRNA. Translation: AAH18697.2.
BC021210 mRNA. Translation: AAH21210.2.
BC033207 mRNA. Translation: AAH33207.1.
CCDSiCCDS33068.1. [Q8WTR8-1]
RefSeqiNP_665806.1. NM_145807.2. [Q8WTR8-1]
XP_006723074.1. XM_006723011.1. [Q8WTR8-1]
UniGeneiHs.326217.

3D structure databases

ProteinModelPortaliQ8WTR8.
SMRiQ8WTR8. Positions 16-349.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4723142.

Polymorphism databases

DMDMi74730628.

Proteomic databases

PaxDbiQ8WTR8.
PRIDEiQ8WTR8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000270235; ENSP00000270235; ENSG00000142233. [Q8WTR8-1]
GeneIDi126147.
KEGGihsa:126147.
UCSCiuc002pkb.3. human. [Q8WTR8-1]
uc002pkc.3. human. [Q8WTR8-2]

Organism-specific databases

CTDi126147.
GeneCardsiGC19M049164.
HGNCiHGNC:25208. NTN5.
neXtProtiNX_Q8WTR8.
PharmGKBiPA164724232.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG327968.
GeneTreeiENSGT00780000121873.
HOGENOMiHOG000286017.
HOVERGENiHBG096704.
InParanoidiQ8WTR8.
OMAiYSSDPQC.
OrthoDBiEOG7XM2XH.
PhylomeDBiQ8WTR8.
TreeFamiTF352481.

Miscellaneous databases

GenomeRNAii126147.
NextBioi81704.
PROiQ8WTR8.

Gene expression databases

BgeeiQ8WTR8.
ExpressionAtlasiQ8WTR8. baseline and differential.
GenevestigatoriQ8WTR8.

Family and domain databases

InterProiIPR002049. EGF_laminin.
IPR001134. Netrin_domain.
IPR018933. Netrin_module_non-TIMP.
IPR008993. TIMP-like_OB-fold.
[Graphical view]
PfamiPF00053. Laminin_EGF. 3 hits.
PF01759. NTR. 1 hit.
[Graphical view]
SMARTiSM00643. C345C. 1 hit.
SM00180. EGF_Lam. 3 hits.
[Graphical view]
SUPFAMiSSF50242. SSF50242. 1 hit.
PROSITEiPS00022. EGF_1. 2 hits.
PS01248. EGF_LAM_1. 2 hits.
PS50027. EGF_LAM_2. 3 hits.
PS50189. NTR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Muscle.

Entry informationi

Entry nameiNET5_HUMAN
AccessioniPrimary (citable) accession number: Q8WTR8
Secondary accession number(s): Q8N4X9, Q8WU63
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 25, 2008
Last sequence update: July 4, 2004
Last modified: March 3, 2015
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.