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Q8WTR7

- ZN473_HUMAN

UniProt

Q8WTR7 - ZN473_HUMAN

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Protein

Zinc finger protein 473

Gene

ZNF473

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Involved in histone 3'-end pre-mRNA processing by associating with U7 snRNP and interacting with SLBP/pre-mRNA complex. Increases histone 3'-end pre-mRNA processing but has no effect on U7 snRNP levels, when overexpressed. Required for cell cycle progression from G1 to S phases.3 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri209 – 23123C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri265 – 28622C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri320 – 34223C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri347 – 36923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri375 – 39723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri403 – 42523C2H2-type 6; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri431 – 45323C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri459 – 48123C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri487 – 50923C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri515 – 53723C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri562 – 58423C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri591 – 61323C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri646 – 66823C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri674 – 69623C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri702 – 72423C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri730 – 75223C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri758 – 78023C2H2-type 17PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri786 – 80823C2H2-type 18PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri814 – 83623C2H2-type 19PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri842 – 86423C2H2-type 20PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. gene expression Source: Reactome
  2. histone mRNA 3'-end processing Source: UniProtKB
  3. histone mRNA metabolic process Source: Reactome
  4. mRNA 3'-end processing Source: Reactome
  5. regulation of transcription, DNA-templated Source: InterPro
  6. termination of RNA polymerase II transcription Source: Reactome
  7. transcription from RNA polymerase II promoter Source: Reactome
Complete GO annotation...

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_12627. Generic Transcription Pathway.
REACT_1364. SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs.
REACT_185. SLBP independent Processing of Histone Pre-mRNAs.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 473
Alternative name(s):
Zinc finger protein 100 homolog
Short name:
Zfp-100
Gene namesi
Name:ZNF473
Synonyms:KIAA1141, ZFP100
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:23239. ZNF473.

Subcellular locationi

Nucleus 1 Publication
Note: Stable component of Cajal bodies (CBs). Colocalizes with SMN, coilin and U7 snRNA.

GO - Cellular componenti

  1. Cajal body Source: UniProtKB
  2. nucleoplasm Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134987987.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 871871Zinc finger protein 473PRO_0000047604Add
BLAST

Proteomic databases

PaxDbiQ8WTR7.
PRIDEiQ8WTR7.

PTM databases

PhosphoSiteiQ8WTR7.

Expressioni

Gene expression databases

BgeeiQ8WTR7.
CleanExiHS_ZNF473.
ExpressionAtlasiQ8WTR7. baseline and differential.
GenevestigatoriQ8WTR7.

Organism-specific databases

HPAiHPA004191.

Interactioni

Subunit structurei

Interacts with the SLBP/pre-mRNA complex but not with SLBP alone. Interacts with LSM11 in a U7 snRNP-dependent manner.4 Publications

Protein-protein interaction databases

BioGridi117398. 7 interactions.
IntActiQ8WTR7. 4 interactions.
MINTiMINT-1441474.
STRINGi9606.ENSP00000270617.

Structurei

Secondary structure

1
871
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi212 – 2143Combined sources
Helixi221 – 2288Combined sources
Helixi230 – 2334Combined sources
Beta strandi320 – 3223Combined sources
Turni323 – 3264Combined sources
Beta strandi327 – 3326Combined sources
Helixi333 – 3364Combined sources
Helixi339 – 3424Combined sources
Beta strandi345 – 3484Combined sources
Turni350 – 3523Combined sources
Beta strandi355 – 3573Combined sources
Helixi359 – 3657Combined sources
Helixi366 – 3694Combined sources
Beta strandi370 – 3723Combined sources
Turni378 – 3803Combined sources
Helixi387 – 39711Combined sources
Beta strandi430 – 4323Combined sources
Beta strandi434 – 4363Combined sources
Beta strandi439 – 4424Combined sources
Helixi443 – 45311Combined sources
Turni490 – 4923Combined sources
Helixi499 – 50810Combined sources
Beta strandi565 – 5673Combined sources
Beta strandi570 – 5745Combined sources
Helixi575 – 5817Combined sources
Beta strandi645 – 6473Combined sources
Beta strandi649 – 6513Combined sources
Beta strandi654 – 6574Combined sources
Helixi658 – 6658Combined sources
Turni666 – 6705Combined sources
Beta strandi673 – 6753Combined sources
Beta strandi677 – 6804Combined sources
Beta strandi682 – 6865Combined sources
Helixi687 – 6959Combined sources
Turni705 – 7073Combined sources
Beta strandi710 – 7134Combined sources
Helixi714 – 7218Combined sources
Turni722 – 7243Combined sources
Beta strandi729 – 7313Combined sources
Beta strandi733 – 7353Combined sources
Beta strandi738 – 7414Combined sources
Helixi742 – 7498Combined sources
Helixi750 – 7523Combined sources
Beta strandi761 – 7633Combined sources
Beta strandi768 – 7714Combined sources
Helixi772 – 7787Combined sources
Beta strandi789 – 7913Combined sources
Beta strandi794 – 7974Combined sources
Helixi798 – 8058Combined sources
Turni806 – 8083Combined sources
Beta strandi813 – 8164Combined sources
Turni817 – 8204Combined sources
Beta strandi821 – 8255Combined sources
Helixi826 – 83611Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2EMBNMR-A342-372[»]
2EMCNMR-A641-673[»]
2EMENMR-A725-757[»]
2EOUNMR-A370-400[»]
2EOXNMR-A315-345[»]
2EOYNMR-A557-589[»]
2EOZNMR-A809-841[»]
2YRHNMR-A699-729[»]
2YRJNMR-A781-813[»]
2YSVNMR-A755-783[»]
2YTDNMR-A426-458[»]
2YTENMR-A484-512[»]
2YTTNMR-A204-236[»]
2YU5NMR-A669-699[»]
ProteinModelPortaliQ8WTR7.
SMRiQ8WTR7. Positions 171-867.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8WTR7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 7570KRABPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni312 – 552241Interaction with SLBP/pre-mRNA complexAdd
BLAST

Domaini

The C2H2-type zinc finger 2 to 6 are necessary and sufficient for discrete Cajal bodies localization. The C2H2-type zinc finger 5 to 10 are necessary and sufficient for interaction with LSM11. The C2H2-type zinc finger 2 to 8 are necessary for interaction with the SLBP/RNA complex in the histone pre-mRNAs. The C2H2-type zinc finger 2 to 10 confer activity in histone pre-mRNA processing.

Sequence similaritiesi

Contains 20 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri209 – 23123C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri265 – 28622C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri320 – 34223C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri347 – 36923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri375 – 39723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri403 – 42523C2H2-type 6; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri431 – 45323C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri459 – 48123C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri487 – 50923C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri515 – 53723C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri562 – 58423C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri591 – 61323C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri646 – 66823C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri674 – 69623C2H2-type 14PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri702 – 72423C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri730 – 75223C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri758 – 78023C2H2-type 17PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri786 – 80823C2H2-type 18PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri814 – 83623C2H2-type 19PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri842 – 86423C2H2-type 20PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
GeneTreeiENSGT00760000118980.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8WTR7.
KOiK09228.
OMAiCAECKET.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ8WTR7.
TreeFamiTF350932.

Family and domain databases

Gene3Di3.30.160.60. 21 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 20 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 18 hits.
PS50157. ZINC_FINGER_C2H2_2. 20 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WTR7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAEEFVTLKD VGMDFTLGDW EQLGLEQGDT FWDTALDNCQ DLFLLDPPRP
60 70 80 90 100
NLTSHPDGSE DLEPLAGGSP EATSPDVTET KNSPLMEDFF EEGFSQEIIE
110 120 130 140 150
MLSKDGFWNS NFGEACIEDT WLDSLLGDPE SLLRSDIATN GESPTECKSH
160 170 180 190 200
ELKRGLSPVS TVSTGEDSMV HNVSEKTLTP AKSKEYRGEF FSYSDHSQQD
210 220 230 240 250
SVQEGEKPYQ CSECGKSFSG SYRLTQHWIT HTREKPTVHQ ECEQGFDRNA
260 270 280 290 300
SLSVYPKTHT GYKFYVCNEY GTTFSQSTYL WHQKTHTGEK PCKSQDSDHP
310 320 330 340 350
PSHDTQPGEH QKTHTDSKSY NCNECGKAFT RIFHLTRHQK IHTRKRYECS
360 370 380 390 400
KCQATFNLRK HLIQHQKTHA AKTTSECQEC GKIFRHSSLL IEHQALHAGE
410 420 430 440 450
EPYKCNERGK SFRHNSTLKI HQRVHSGEKP YKCSECGKAF HRHTHLNEHR
460 470 480 490 500
RIHTGYRPHK CQECVRSFSR PSHLMRHQAI HTAEKPYSCA ECKETFSDNN
510 520 530 540 550
RLVQHQKMHT VKTPYECQEC GERFICGSTL KCHESVHARE KQGFFVSGKI
560 570 580 590 600
LDQNPEQKEK CFKCNKCEKT FSCSKYLTQH ERIHTRGVKP FECDQCGKAF
610 620 630 640 650
GQSTRLIHHQ RIHSRVRLYK WGEQGKAISS ASLIKLQSFH TKEHPFKCNE
660 670 680 690 700
CGKTFSHSAH LSKHQLIHAG ENPFKCSKCD RVFTQRNYLV QHERTHARKK
710 720 730 740 750
PLVCNECGKT FRQSSCLSKH QRIHSGEKPY VCDYCGKAFG LSAELVRHQR
760 770 780 790 800
IHTGEKPYVC QECGKAFTQS SCLSIHRRVH TGEKPYRCGE CGKAFAQKAN
810 820 830 840 850
LTQHQRIHTG EKPYSCNVCG KAFVLSAHLN QHLRVHTQET LYQCQRCQKA
860 870
FRCHSSLSRH QRVHNKQQYC L
Length:871
Mass (Da):100,182
Last modified:March 1, 2002 - v1
Checksum:i959AFB7C3C2D5456
GO

Sequence cautioni

The sequence BAA86455.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti486 – 4861P → A(PubMed:17974005)Curated
Sequence conflicti588 – 5881V → M in BAA86455. (PubMed:10574461)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti59 – 591S → G.
Corresponds to variant rs10419876 [ dbSNP | Ensembl ].
VAR_052839
Natural varianti74 – 741S → G.
Corresponds to variant rs10419911 [ dbSNP | Ensembl ].
VAR_052840
Natural varianti164 – 1641T → M.
Corresponds to variant rs16981705 [ dbSNP | Ensembl ].
VAR_052841
Natural varianti309 – 3091E → G.
Corresponds to variant rs16981706 [ dbSNP | Ensembl ].
VAR_052842
Natural varianti654 – 6541T → I.
Corresponds to variant rs10424809 [ dbSNP | Ensembl ].
VAR_052843
Natural varianti662 – 6621S → A.
Corresponds to variant rs10426374 [ dbSNP | Ensembl ].
VAR_052844

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF454744 mRNA. Translation: AAL51029.1.
AB032967 mRNA. Translation: BAA86455.1. Different initiation.
AK292452 mRNA. Translation: BAF85141.1.
CH471177 Genomic DNA. Translation: EAW52593.1.
BC018612 mRNA. Translation: AAH18612.1.
AL080143 mRNA. Translation: CAB45736.1.
CCDSiCCDS33077.1.
PIRiT12527.
RefSeqiNP_001006657.1. NM_001006656.1.
NP_056243.1. NM_015428.1.
UniGeneiHs.440553.

Genome annotation databases

EnsembliENST00000270617; ENSP00000270617; ENSG00000142528.
ENST00000391821; ENSP00000375697; ENSG00000142528.
ENST00000595661; ENSP00000472808; ENSG00000142528.
GeneIDi25888.
KEGGihsa:25888.
UCSCiuc002prm.3. human.

Polymorphism databases

DMDMi51702187.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF454744 mRNA. Translation: AAL51029.1 .
AB032967 mRNA. Translation: BAA86455.1 . Different initiation.
AK292452 mRNA. Translation: BAF85141.1 .
CH471177 Genomic DNA. Translation: EAW52593.1 .
BC018612 mRNA. Translation: AAH18612.1 .
AL080143 mRNA. Translation: CAB45736.1 .
CCDSi CCDS33077.1.
PIRi T12527.
RefSeqi NP_001006657.1. NM_001006656.1.
NP_056243.1. NM_015428.1.
UniGenei Hs.440553.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2EMB NMR - A 342-372 [» ]
2EMC NMR - A 641-673 [» ]
2EME NMR - A 725-757 [» ]
2EOU NMR - A 370-400 [» ]
2EOX NMR - A 315-345 [» ]
2EOY NMR - A 557-589 [» ]
2EOZ NMR - A 809-841 [» ]
2YRH NMR - A 699-729 [» ]
2YRJ NMR - A 781-813 [» ]
2YSV NMR - A 755-783 [» ]
2YTD NMR - A 426-458 [» ]
2YTE NMR - A 484-512 [» ]
2YTT NMR - A 204-236 [» ]
2YU5 NMR - A 669-699 [» ]
ProteinModelPortali Q8WTR7.
SMRi Q8WTR7. Positions 171-867.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117398. 7 interactions.
IntActi Q8WTR7. 4 interactions.
MINTi MINT-1441474.
STRINGi 9606.ENSP00000270617.

PTM databases

PhosphoSitei Q8WTR7.

Polymorphism databases

DMDMi 51702187.

Proteomic databases

PaxDbi Q8WTR7.
PRIDEi Q8WTR7.

Protocols and materials databases

DNASUi 25888.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000270617 ; ENSP00000270617 ; ENSG00000142528 .
ENST00000391821 ; ENSP00000375697 ; ENSG00000142528 .
ENST00000595661 ; ENSP00000472808 ; ENSG00000142528 .
GeneIDi 25888.
KEGGi hsa:25888.
UCSCi uc002prm.3. human.

Organism-specific databases

CTDi 25888.
GeneCardsi GC19P050529.
HGNCi HGNC:23239. ZNF473.
HPAi HPA004191.
neXtProti NX_Q8WTR7.
PharmGKBi PA134987987.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
GeneTreei ENSGT00760000118980.
HOGENOMi HOG000234617.
HOVERGENi HBG018163.
InParanoidi Q8WTR7.
KOi K09228.
OMAi CAECKET.
OrthoDBi EOG7KSX7Q.
PhylomeDBi Q8WTR7.
TreeFami TF350932.

Enzyme and pathway databases

Reactomei REACT_12627. Generic Transcription Pathway.
REACT_1364. SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs.
REACT_185. SLBP independent Processing of Histone Pre-mRNAs.

Miscellaneous databases

EvolutionaryTracei Q8WTR7.
GeneWikii ZNF473.
GenomeRNAii 25888.
NextBioi 47312.
PROi Q8WTR7.

Gene expression databases

Bgeei Q8WTR7.
CleanExi HS_ZNF473.
ExpressionAtlasi Q8WTR7. baseline and differential.
Genevestigatori Q8WTR7.

Family and domain databases

Gene3Di 3.30.160.60. 21 hits.
InterProi IPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 3 hits.
[Graphical view ]
SMARTi SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 20 hits.
[Graphical view ]
SUPFAMi SSF109640. SSF109640. 1 hit.
PROSITEi PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 18 hits.
PS50157. ZINC_FINGER_C2H2_2. 20 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel zinc finger protein is associated with U7 snRNP and interacts with the stem-loop binding protein in the histone pre-mRNP to stimulate 3'-end processing."
    Dominski Z., Erkmann J.A., Yang X., Sanchez R., Marzluff W.F.
    Genes Dev. 16:58-71(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH SLBP/PRE-MRNA COMPLEX.
  2. "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain."
    Hirosawa M., Nagase T., Ishikawa K., Kikuno R., Nomura N., Ohara O.
    DNA Res. 6:329-336(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 486-871.
    Tissue: Testis.
  7. "Unique Sm core structure of U7 snRNPs: assembly by a specialized SMN complex and the role of a new component, Lsm11, in histone RNA processing."
    Pillai R.S., Grimmler M., Meister G., Will C.L., Luehrmann R., Fischer U., Schuemperli D.
    Genes Dev. 17:2321-2333(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH LSM11.
    Tissue: Cervix carcinoma.
  8. "U7 snRNP-specific Lsm11 protein: dual binding contacts with the 100 kDa zinc finger processing factor (ZFP100) and a ZFP100-independent function in histone RNA 3'-end processing."
    Azzouz T.N., Gruber A., Schuemperli D.
    Nucleic Acids Res. 33:2106-2117(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH LSM11.
  9. "ZFP100, a component of the active U7 snRNP limiting for histone pre-mRNA processing, is required for entry into S phase."
    Wagner E.J., Marzluff W.F.
    Mol. Cell. Biol. 26:6702-6712(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  10. "Conserved zinc fingers mediate multiple functions of ZFP100, a U7snRNP associated protein."
    Wagner E.J., Ospina J.K., Hu Y., Dundr M., Matera A.G., Marzluff W.F.
    RNA 12:1206-1218(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH LSM11, SUBCELLULAR LOCATION.
  11. "Solution structure of the C2H2 type zinc finger region of human zinc finger protein 473."
    RIKEN structural genomics initiative (RSGI)
    Submitted (OCT-2007) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 205-841.

Entry informationi

Entry nameiZN473_HUMAN
AccessioniPrimary (citable) accession number: Q8WTR7
Secondary accession number(s): A8K8T7, Q9ULS9, Q9Y4Q7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: March 1, 2002
Last modified: November 26, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

External Data

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