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Protein

Zinc finger protein 473

Gene

ZNF473

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in histone 3'-end pre-mRNA processing by associating with U7 snRNP and interacting with SLBP/pre-mRNA complex. Increases histone 3'-end pre-mRNA processing but has no effect on U7 snRNP levels, when overexpressed. Required for cell cycle progression from G1 to S phases.3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri209 – 231C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri265 – 286C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST22
Zinc fingeri320 – 342C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri347 – 369C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri375 – 397C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri403 – 425C2H2-type 6; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri431 – 453C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri459 – 481C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri487 – 509C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri515 – 537C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri562 – 584C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri591 – 613C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri646 – 668C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri674 – 696C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri702 – 724C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri730 – 752C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri758 – 780C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri786 – 808C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri814 – 836C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri842 – 864C2H2-type 20PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-109688. Cleavage of Growing Transcript in the Termination Region.
R-HSA-111367. SLBP independent Processing of Histone Pre-mRNAs.
R-HSA-212436. Generic Transcription Pathway.
R-HSA-77588. SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 473
Alternative name(s):
Zinc finger protein 100 homolog
Short name:
Zfp-100
Gene namesi
Name:ZNF473
Synonyms:KIAA1141, ZFP100
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:23239. ZNF473.

Subcellular locationi

  • Nucleus 1 Publication

  • Note: Stable component of Cajal bodies (CBs). Colocalizes with SMN, coilin and U7 snRNA.

GO - Cellular componenti

  • Cajal body Source: UniProtKB
  • nucleoplasm Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi25888.
OpenTargetsiENSG00000142528.
PharmGKBiPA134987987.

Polymorphism and mutation databases

BioMutaiZNF473.
DMDMi51702187.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000476041 – 871Zinc finger protein 473Add BLAST871

Proteomic databases

EPDiQ8WTR7.
PaxDbiQ8WTR7.
PeptideAtlasiQ8WTR7.
PRIDEiQ8WTR7.

PTM databases

iPTMnetiQ8WTR7.
PhosphoSitePlusiQ8WTR7.

Expressioni

Gene expression databases

BgeeiENSG00000142528.
CleanExiHS_ZNF473.
ExpressionAtlasiQ8WTR7. baseline and differential.
GenevisibleiQ8WTR7. HS.

Organism-specific databases

HPAiHPA004191.
HPA073309.

Interactioni

Subunit structurei

Interacts with the SLBP/pre-mRNA complex but not with SLBP alone. Interacts with LSM11 in a U7 snRNP-dependent manner.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
AENQ8WTP83EBI-751409,EBI-8637627
CLK2P497603EBI-751409,EBI-750020
DHX57Q6P1583EBI-751409,EBI-1051531
GPATCH2LQ9NWQ43EBI-751409,EBI-5666657
KRTAP10-8P604105EBI-751409,EBI-10171774
KRTAP10-9P604113EBI-751409,EBI-10172052
RNPS1D3DU923EBI-751409,EBI-10176640
TRIM41Q8WV443EBI-751409,EBI-725997
ZNF250P15622-33EBI-751409,EBI-10177272
ZNF792Q3KQV33EBI-751409,EBI-10240849
ZSCAN12O433093EBI-751409,EBI-1210440

Protein-protein interaction databases

BioGridi117398. 15 interactors.
IntActiQ8WTR7. 18 interactors.
MINTiMINT-1441474.
STRINGi9606.ENSP00000270617.

Structurei

Secondary structure

1871
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi212 – 214Combined sources3
Helixi221 – 228Combined sources8
Helixi230 – 233Combined sources4
Beta strandi320 – 322Combined sources3
Turni323 – 326Combined sources4
Beta strandi327 – 332Combined sources6
Helixi333 – 336Combined sources4
Helixi339 – 342Combined sources4
Beta strandi345 – 348Combined sources4
Turni350 – 352Combined sources3
Beta strandi355 – 357Combined sources3
Helixi359 – 365Combined sources7
Helixi366 – 369Combined sources4
Beta strandi370 – 372Combined sources3
Turni378 – 380Combined sources3
Helixi387 – 397Combined sources11
Beta strandi430 – 432Combined sources3
Beta strandi434 – 436Combined sources3
Beta strandi439 – 442Combined sources4
Helixi443 – 453Combined sources11
Turni490 – 492Combined sources3
Helixi499 – 508Combined sources10
Beta strandi565 – 567Combined sources3
Beta strandi570 – 574Combined sources5
Helixi575 – 581Combined sources7
Beta strandi645 – 647Combined sources3
Beta strandi649 – 651Combined sources3
Beta strandi654 – 657Combined sources4
Helixi658 – 665Combined sources8
Turni666 – 670Combined sources5
Beta strandi673 – 675Combined sources3
Beta strandi677 – 680Combined sources4
Beta strandi682 – 686Combined sources5
Helixi687 – 695Combined sources9
Turni705 – 707Combined sources3
Beta strandi710 – 713Combined sources4
Helixi714 – 721Combined sources8
Turni722 – 724Combined sources3
Beta strandi729 – 731Combined sources3
Beta strandi733 – 735Combined sources3
Beta strandi738 – 741Combined sources4
Helixi742 – 749Combined sources8
Helixi750 – 752Combined sources3
Beta strandi761 – 763Combined sources3
Beta strandi768 – 771Combined sources4
Helixi772 – 778Combined sources7
Beta strandi789 – 791Combined sources3
Beta strandi794 – 797Combined sources4
Helixi798 – 805Combined sources8
Turni806 – 808Combined sources3
Beta strandi813 – 816Combined sources4
Turni817 – 820Combined sources4
Beta strandi821 – 825Combined sources5
Helixi826 – 836Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EMBNMR-A342-372[»]
2EMCNMR-A641-673[»]
2EMENMR-A725-757[»]
2EOUNMR-A370-400[»]
2EOXNMR-A315-345[»]
2EOYNMR-A557-589[»]
2EOZNMR-A809-841[»]
2YRHNMR-A699-729[»]
2YRJNMR-A781-813[»]
2YSVNMR-A755-783[»]
2YTDNMR-A426-458[»]
2YTENMR-A484-512[»]
2YTTNMR-A204-236[»]
2YU5NMR-A669-699[»]
ProteinModelPortaliQ8WTR7.
SMRiQ8WTR7.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8WTR7.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 75KRABPROSITE-ProRule annotationAdd BLAST70

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni312 – 552Interaction with SLBP/pre-mRNA complexAdd BLAST241

Domaini

The C2H2-type zinc finger 2 to 6 are necessary and sufficient for discrete Cajal bodies localization. The C2H2-type zinc finger 5 to 10 are necessary and sufficient for interaction with LSM11. The C2H2-type zinc finger 2 to 8 are necessary for interaction with the SLBP/RNA complex in the histone pre-mRNAs. The C2H2-type zinc finger 2 to 10 confer activity in histone pre-mRNA processing.

Sequence similaritiesi

Contains 20 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri209 – 231C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri265 – 286C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST22
Zinc fingeri320 – 342C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri347 – 369C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri375 – 397C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri403 – 425C2H2-type 6; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri431 – 453C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri459 – 481C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri487 – 509C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri515 – 537C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri562 – 584C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri591 – 613C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri646 – 668C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri674 – 696C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri702 – 724C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri730 – 752C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri758 – 780C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri786 – 808C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri814 – 836C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri842 – 864C2H2-type 20PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000130048.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8WTR7.
KOiK09228.
OMAiCAECKET.
OrthoDBiEOG091G02KC.
PhylomeDBiQ8WTR7.
TreeFamiTF350932.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 21 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 20 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 18 hits.
PS50157. ZINC_FINGER_C2H2_2. 20 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WTR7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEEFVTLKD VGMDFTLGDW EQLGLEQGDT FWDTALDNCQ DLFLLDPPRP
60 70 80 90 100
NLTSHPDGSE DLEPLAGGSP EATSPDVTET KNSPLMEDFF EEGFSQEIIE
110 120 130 140 150
MLSKDGFWNS NFGEACIEDT WLDSLLGDPE SLLRSDIATN GESPTECKSH
160 170 180 190 200
ELKRGLSPVS TVSTGEDSMV HNVSEKTLTP AKSKEYRGEF FSYSDHSQQD
210 220 230 240 250
SVQEGEKPYQ CSECGKSFSG SYRLTQHWIT HTREKPTVHQ ECEQGFDRNA
260 270 280 290 300
SLSVYPKTHT GYKFYVCNEY GTTFSQSTYL WHQKTHTGEK PCKSQDSDHP
310 320 330 340 350
PSHDTQPGEH QKTHTDSKSY NCNECGKAFT RIFHLTRHQK IHTRKRYECS
360 370 380 390 400
KCQATFNLRK HLIQHQKTHA AKTTSECQEC GKIFRHSSLL IEHQALHAGE
410 420 430 440 450
EPYKCNERGK SFRHNSTLKI HQRVHSGEKP YKCSECGKAF HRHTHLNEHR
460 470 480 490 500
RIHTGYRPHK CQECVRSFSR PSHLMRHQAI HTAEKPYSCA ECKETFSDNN
510 520 530 540 550
RLVQHQKMHT VKTPYECQEC GERFICGSTL KCHESVHARE KQGFFVSGKI
560 570 580 590 600
LDQNPEQKEK CFKCNKCEKT FSCSKYLTQH ERIHTRGVKP FECDQCGKAF
610 620 630 640 650
GQSTRLIHHQ RIHSRVRLYK WGEQGKAISS ASLIKLQSFH TKEHPFKCNE
660 670 680 690 700
CGKTFSHSAH LSKHQLIHAG ENPFKCSKCD RVFTQRNYLV QHERTHARKK
710 720 730 740 750
PLVCNECGKT FRQSSCLSKH QRIHSGEKPY VCDYCGKAFG LSAELVRHQR
760 770 780 790 800
IHTGEKPYVC QECGKAFTQS SCLSIHRRVH TGEKPYRCGE CGKAFAQKAN
810 820 830 840 850
LTQHQRIHTG EKPYSCNVCG KAFVLSAHLN QHLRVHTQET LYQCQRCQKA
860 870
FRCHSSLSRH QRVHNKQQYC L
Length:871
Mass (Da):100,182
Last modified:March 1, 2002 - v1
Checksum:i959AFB7C3C2D5456
GO

Sequence cautioni

The sequence BAA86455 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti486P → A (PubMed:17974005).Curated1
Sequence conflicti588V → M in BAA86455 (PubMed:10574461).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05283959S → G.Corresponds to variant rs10419876dbSNPEnsembl.1
Natural variantiVAR_05284074S → G.Corresponds to variant rs10419911dbSNPEnsembl.1
Natural variantiVAR_052841164T → M.Corresponds to variant rs16981705dbSNPEnsembl.1
Natural variantiVAR_052842309E → G.Corresponds to variant rs16981706dbSNPEnsembl.1
Natural variantiVAR_052843654T → I.Corresponds to variant rs10424809dbSNPEnsembl.1
Natural variantiVAR_052844662S → A.Corresponds to variant rs10426374dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF454744 mRNA. Translation: AAL51029.1.
AB032967 mRNA. Translation: BAA86455.1. Different initiation.
AK292452 mRNA. Translation: BAF85141.1.
CH471177 Genomic DNA. Translation: EAW52593.1.
BC018612 mRNA. Translation: AAH18612.1.
AL080143 mRNA. Translation: CAB45736.1.
CCDSiCCDS33077.1.
PIRiT12527.
RefSeqiNP_001006657.1. NM_001006656.3.
NP_001295353.1. NM_001308424.2.
NP_056243.1. NM_015428.3.
UniGeneiHs.440553.

Genome annotation databases

EnsembliENST00000270617; ENSP00000270617; ENSG00000142528.
ENST00000391821; ENSP00000375697; ENSG00000142528.
ENST00000595661; ENSP00000472808; ENSG00000142528.
GeneIDi25888.
KEGGihsa:25888.
UCSCiuc002prm.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF454744 mRNA. Translation: AAL51029.1.
AB032967 mRNA. Translation: BAA86455.1. Different initiation.
AK292452 mRNA. Translation: BAF85141.1.
CH471177 Genomic DNA. Translation: EAW52593.1.
BC018612 mRNA. Translation: AAH18612.1.
AL080143 mRNA. Translation: CAB45736.1.
CCDSiCCDS33077.1.
PIRiT12527.
RefSeqiNP_001006657.1. NM_001006656.3.
NP_001295353.1. NM_001308424.2.
NP_056243.1. NM_015428.3.
UniGeneiHs.440553.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EMBNMR-A342-372[»]
2EMCNMR-A641-673[»]
2EMENMR-A725-757[»]
2EOUNMR-A370-400[»]
2EOXNMR-A315-345[»]
2EOYNMR-A557-589[»]
2EOZNMR-A809-841[»]
2YRHNMR-A699-729[»]
2YRJNMR-A781-813[»]
2YSVNMR-A755-783[»]
2YTDNMR-A426-458[»]
2YTENMR-A484-512[»]
2YTTNMR-A204-236[»]
2YU5NMR-A669-699[»]
ProteinModelPortaliQ8WTR7.
SMRiQ8WTR7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117398. 15 interactors.
IntActiQ8WTR7. 18 interactors.
MINTiMINT-1441474.
STRINGi9606.ENSP00000270617.

PTM databases

iPTMnetiQ8WTR7.
PhosphoSitePlusiQ8WTR7.

Polymorphism and mutation databases

BioMutaiZNF473.
DMDMi51702187.

Proteomic databases

EPDiQ8WTR7.
PaxDbiQ8WTR7.
PeptideAtlasiQ8WTR7.
PRIDEiQ8WTR7.

Protocols and materials databases

DNASUi25888.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000270617; ENSP00000270617; ENSG00000142528.
ENST00000391821; ENSP00000375697; ENSG00000142528.
ENST00000595661; ENSP00000472808; ENSG00000142528.
GeneIDi25888.
KEGGihsa:25888.
UCSCiuc002prm.4. human.

Organism-specific databases

CTDi25888.
DisGeNETi25888.
GeneCardsiZNF473.
HGNCiHGNC:23239. ZNF473.
HPAiHPA004191.
HPA073309.
neXtProtiNX_Q8WTR7.
OpenTargetsiENSG00000142528.
PharmGKBiPA134987987.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000130048.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ8WTR7.
KOiK09228.
OMAiCAECKET.
OrthoDBiEOG091G02KC.
PhylomeDBiQ8WTR7.
TreeFamiTF350932.

Enzyme and pathway databases

ReactomeiR-HSA-109688. Cleavage of Growing Transcript in the Termination Region.
R-HSA-111367. SLBP independent Processing of Histone Pre-mRNAs.
R-HSA-212436. Generic Transcription Pathway.
R-HSA-77588. SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs.

Miscellaneous databases

EvolutionaryTraceiQ8WTR7.
GeneWikiiZNF473.
GenomeRNAii25888.
PROiQ8WTR7.

Gene expression databases

BgeeiENSG00000142528.
CleanExiHS_ZNF473.
ExpressionAtlasiQ8WTR7. baseline and differential.
GenevisibleiQ8WTR7. HS.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 21 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 20 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 18 hits.
PS50157. ZINC_FINGER_C2H2_2. 20 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN473_HUMAN
AccessioniPrimary (citable) accession number: Q8WTR7
Secondary accession number(s): A8K8T7, Q9ULS9, Q9Y4Q7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: March 1, 2002
Last modified: November 30, 2016
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.