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Q8WTR7

- ZN473_HUMAN

UniProt

Q8WTR7 - ZN473_HUMAN

Protein

Zinc finger protein 473

Gene

ZNF473

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Involved in histone 3'-end pre-mRNA processing by associating with U7 snRNP and interacting with SLBP/pre-mRNA complex. Increases histone 3'-end pre-mRNA processing but has no effect on U7 snRNP levels, when overexpressed. Required for cell cycle progression from G1 to S phases.3 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri209 – 23123C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri265 – 28622C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri320 – 34223C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri347 – 36923C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri375 – 39723C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri403 – 42523C2H2-type 6; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri431 – 45323C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri459 – 48123C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri487 – 50923C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri515 – 53723C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri562 – 58423C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri591 – 61323C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri646 – 66823C2H2-type 13PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri674 – 69623C2H2-type 14PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri702 – 72423C2H2-type 15PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri730 – 75223C2H2-type 16PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri758 – 78023C2H2-type 17PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri786 – 80823C2H2-type 18PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri814 – 83623C2H2-type 19PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri842 – 86423C2H2-type 20PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. protein binding Source: UniProtKB

    GO - Biological processi

    1. gene expression Source: Reactome
    2. histone mRNA 3'-end processing Source: UniProtKB
    3. histone mRNA metabolic process Source: Reactome
    4. mRNA 3'-end processing Source: Reactome
    5. regulation of transcription, DNA-templated Source: InterPro
    6. termination of RNA polymerase II transcription Source: Reactome
    7. transcription from RNA polymerase II promoter Source: Reactome

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_12627. Generic Transcription Pathway.
    REACT_1364. SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs.
    REACT_185. SLBP independent Processing of Histone Pre-mRNAs.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 473
    Alternative name(s):
    Zinc finger protein 100 homolog
    Short name:
    Zfp-100
    Gene namesi
    Name:ZNF473
    Synonyms:KIAA1141, ZFP100
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:23239. ZNF473.

    Subcellular locationi

    Nucleus 1 Publication
    Note: Stable component of Cajal bodies (CBs). Colocalizes with SMN, coilin and U7 snRNA.

    GO - Cellular componenti

    1. Cajal body Source: UniProtKB
    2. nucleoplasm Source: Reactome

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134987987.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 871871Zinc finger protein 473PRO_0000047604Add
    BLAST

    Proteomic databases

    PaxDbiQ8WTR7.
    PRIDEiQ8WTR7.

    PTM databases

    PhosphoSiteiQ8WTR7.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8WTR7.
    BgeeiQ8WTR7.
    CleanExiHS_ZNF473.
    GenevestigatoriQ8WTR7.

    Organism-specific databases

    HPAiHPA004191.

    Interactioni

    Subunit structurei

    Interacts with the SLBP/pre-mRNA complex but not with SLBP alone. Interacts with LSM11 in a U7 snRNP-dependent manner.4 Publications

    Protein-protein interaction databases

    BioGridi117398. 7 interactions.
    IntActiQ8WTR7. 4 interactions.
    MINTiMINT-1441474.
    STRINGi9606.ENSP00000270617.

    Structurei

    Secondary structure

    1
    871
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi212 – 2143
    Helixi221 – 2288
    Helixi230 – 2334
    Beta strandi320 – 3223
    Turni323 – 3264
    Beta strandi327 – 3326
    Helixi333 – 3364
    Helixi339 – 3424
    Beta strandi345 – 3484
    Turni350 – 3523
    Beta strandi355 – 3573
    Helixi359 – 3657
    Helixi366 – 3694
    Beta strandi370 – 3723
    Turni378 – 3803
    Helixi387 – 39711
    Beta strandi430 – 4323
    Beta strandi434 – 4363
    Beta strandi439 – 4424
    Helixi443 – 45311
    Turni490 – 4923
    Helixi499 – 50810
    Beta strandi565 – 5673
    Beta strandi570 – 5745
    Helixi575 – 5817
    Beta strandi645 – 6473
    Beta strandi649 – 6513
    Beta strandi654 – 6574
    Helixi658 – 6658
    Turni666 – 6705
    Beta strandi673 – 6753
    Beta strandi677 – 6804
    Beta strandi682 – 6865
    Helixi687 – 6959
    Turni705 – 7073
    Beta strandi710 – 7134
    Helixi714 – 7218
    Turni722 – 7243
    Beta strandi729 – 7313
    Beta strandi733 – 7353
    Beta strandi738 – 7414
    Helixi742 – 7498
    Helixi750 – 7523
    Beta strandi761 – 7633
    Beta strandi768 – 7714
    Helixi772 – 7787
    Beta strandi789 – 7913
    Beta strandi794 – 7974
    Helixi798 – 8058
    Turni806 – 8083
    Beta strandi813 – 8164
    Turni817 – 8204
    Beta strandi821 – 8255
    Helixi826 – 83611

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2EMBNMR-A342-372[»]
    2EMCNMR-A641-673[»]
    2EMENMR-A725-757[»]
    2EOUNMR-A370-400[»]
    2EOXNMR-A315-345[»]
    2EOYNMR-A557-589[»]
    2EOZNMR-A809-841[»]
    2YRHNMR-A699-729[»]
    2YRJNMR-A781-813[»]
    2YSVNMR-A755-783[»]
    2YTDNMR-A426-458[»]
    2YTENMR-A484-512[»]
    2YTTNMR-A204-236[»]
    2YU5NMR-A669-699[»]
    ProteinModelPortaliQ8WTR7.
    SMRiQ8WTR7. Positions 171-867.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ8WTR7.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini6 – 7570KRABPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni312 – 552241Interaction with SLBP/pre-mRNA complexAdd
    BLAST

    Domaini

    The C2H2-type zinc finger 2 to 6 are necessary and sufficient for discrete Cajal bodies localization. The C2H2-type zinc finger 5 to 10 are necessary and sufficient for interaction with LSM11. The C2H2-type zinc finger 2 to 8 are necessary for interaction with the SLBP/RNA complex in the histone pre-mRNAs. The C2H2-type zinc finger 2 to 10 confer activity in histone pre-mRNA processing.

    Sequence similaritiesi

    Contains 20 C2H2-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 KRAB domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri209 – 23123C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri265 – 28622C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri320 – 34223C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri347 – 36923C2H2-type 4PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri375 – 39723C2H2-type 5PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri403 – 42523C2H2-type 6; degeneratePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri431 – 45323C2H2-type 7PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri459 – 48123C2H2-type 8PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri487 – 50923C2H2-type 9PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri515 – 53723C2H2-type 10PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri562 – 58423C2H2-type 11PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri591 – 61323C2H2-type 12PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri646 – 66823C2H2-type 13PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri674 – 69623C2H2-type 14PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri702 – 72423C2H2-type 15PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri730 – 75223C2H2-type 16PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri758 – 78023C2H2-type 17PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri786 – 80823C2H2-type 18PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri814 – 83623C2H2-type 19PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri842 – 86423C2H2-type 20PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000234617.
    HOVERGENiHBG018163.
    InParanoidiQ8WTR7.
    KOiK09228.
    OMAiCAECKET.
    OrthoDBiEOG7KSX7Q.
    PhylomeDBiQ8WTR7.
    TreeFamiTF350932.

    Family and domain databases

    Gene3Di3.30.160.60. 21 hits.
    InterProiIPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF01352. KRAB. 1 hit.
    PF00096. zf-C2H2. 3 hits.
    [Graphical view]
    SMARTiSM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 20 hits.
    [Graphical view]
    SUPFAMiSSF109640. SSF109640. 1 hit.
    PROSITEiPS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 18 hits.
    PS50157. ZINC_FINGER_C2H2_2. 20 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8WTR7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAEEFVTLKD VGMDFTLGDW EQLGLEQGDT FWDTALDNCQ DLFLLDPPRP    50
    NLTSHPDGSE DLEPLAGGSP EATSPDVTET KNSPLMEDFF EEGFSQEIIE 100
    MLSKDGFWNS NFGEACIEDT WLDSLLGDPE SLLRSDIATN GESPTECKSH 150
    ELKRGLSPVS TVSTGEDSMV HNVSEKTLTP AKSKEYRGEF FSYSDHSQQD 200
    SVQEGEKPYQ CSECGKSFSG SYRLTQHWIT HTREKPTVHQ ECEQGFDRNA 250
    SLSVYPKTHT GYKFYVCNEY GTTFSQSTYL WHQKTHTGEK PCKSQDSDHP 300
    PSHDTQPGEH QKTHTDSKSY NCNECGKAFT RIFHLTRHQK IHTRKRYECS 350
    KCQATFNLRK HLIQHQKTHA AKTTSECQEC GKIFRHSSLL IEHQALHAGE 400
    EPYKCNERGK SFRHNSTLKI HQRVHSGEKP YKCSECGKAF HRHTHLNEHR 450
    RIHTGYRPHK CQECVRSFSR PSHLMRHQAI HTAEKPYSCA ECKETFSDNN 500
    RLVQHQKMHT VKTPYECQEC GERFICGSTL KCHESVHARE KQGFFVSGKI 550
    LDQNPEQKEK CFKCNKCEKT FSCSKYLTQH ERIHTRGVKP FECDQCGKAF 600
    GQSTRLIHHQ RIHSRVRLYK WGEQGKAISS ASLIKLQSFH TKEHPFKCNE 650
    CGKTFSHSAH LSKHQLIHAG ENPFKCSKCD RVFTQRNYLV QHERTHARKK 700
    PLVCNECGKT FRQSSCLSKH QRIHSGEKPY VCDYCGKAFG LSAELVRHQR 750
    IHTGEKPYVC QECGKAFTQS SCLSIHRRVH TGEKPYRCGE CGKAFAQKAN 800
    LTQHQRIHTG EKPYSCNVCG KAFVLSAHLN QHLRVHTQET LYQCQRCQKA 850
    FRCHSSLSRH QRVHNKQQYC L 871
    Length:871
    Mass (Da):100,182
    Last modified:March 1, 2002 - v1
    Checksum:i959AFB7C3C2D5456
    GO

    Sequence cautioni

    The sequence BAA86455.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti486 – 4861P → A(PubMed:17974005)Curated
    Sequence conflicti588 – 5881V → M in BAA86455. (PubMed:10574461)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti59 – 591S → G.
    Corresponds to variant rs10419876 [ dbSNP | Ensembl ].
    VAR_052839
    Natural varianti74 – 741S → G.
    Corresponds to variant rs10419911 [ dbSNP | Ensembl ].
    VAR_052840
    Natural varianti164 – 1641T → M.
    Corresponds to variant rs16981705 [ dbSNP | Ensembl ].
    VAR_052841
    Natural varianti309 – 3091E → G.
    Corresponds to variant rs16981706 [ dbSNP | Ensembl ].
    VAR_052842
    Natural varianti654 – 6541T → I.
    Corresponds to variant rs10424809 [ dbSNP | Ensembl ].
    VAR_052843
    Natural varianti662 – 6621S → A.
    Corresponds to variant rs10426374 [ dbSNP | Ensembl ].
    VAR_052844

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF454744 mRNA. Translation: AAL51029.1.
    AB032967 mRNA. Translation: BAA86455.1. Different initiation.
    AK292452 mRNA. Translation: BAF85141.1.
    CH471177 Genomic DNA. Translation: EAW52593.1.
    BC018612 mRNA. Translation: AAH18612.1.
    AL080143 mRNA. Translation: CAB45736.1.
    CCDSiCCDS33077.1.
    PIRiT12527.
    RefSeqiNP_001006657.1. NM_001006656.1.
    NP_056243.1. NM_015428.1.
    UniGeneiHs.440553.

    Genome annotation databases

    EnsembliENST00000270617; ENSP00000270617; ENSG00000142528.
    ENST00000391821; ENSP00000375697; ENSG00000142528.
    ENST00000595661; ENSP00000472808; ENSG00000142528.
    GeneIDi25888.
    KEGGihsa:25888.
    UCSCiuc002prm.3. human.

    Polymorphism databases

    DMDMi51702187.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF454744 mRNA. Translation: AAL51029.1 .
    AB032967 mRNA. Translation: BAA86455.1 . Different initiation.
    AK292452 mRNA. Translation: BAF85141.1 .
    CH471177 Genomic DNA. Translation: EAW52593.1 .
    BC018612 mRNA. Translation: AAH18612.1 .
    AL080143 mRNA. Translation: CAB45736.1 .
    CCDSi CCDS33077.1.
    PIRi T12527.
    RefSeqi NP_001006657.1. NM_001006656.1.
    NP_056243.1. NM_015428.1.
    UniGenei Hs.440553.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2EMB NMR - A 342-372 [» ]
    2EMC NMR - A 641-673 [» ]
    2EME NMR - A 725-757 [» ]
    2EOU NMR - A 370-400 [» ]
    2EOX NMR - A 315-345 [» ]
    2EOY NMR - A 557-589 [» ]
    2EOZ NMR - A 809-841 [» ]
    2YRH NMR - A 699-729 [» ]
    2YRJ NMR - A 781-813 [» ]
    2YSV NMR - A 755-783 [» ]
    2YTD NMR - A 426-458 [» ]
    2YTE NMR - A 484-512 [» ]
    2YTT NMR - A 204-236 [» ]
    2YU5 NMR - A 669-699 [» ]
    ProteinModelPortali Q8WTR7.
    SMRi Q8WTR7. Positions 171-867.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117398. 7 interactions.
    IntActi Q8WTR7. 4 interactions.
    MINTi MINT-1441474.
    STRINGi 9606.ENSP00000270617.

    PTM databases

    PhosphoSitei Q8WTR7.

    Polymorphism databases

    DMDMi 51702187.

    Proteomic databases

    PaxDbi Q8WTR7.
    PRIDEi Q8WTR7.

    Protocols and materials databases

    DNASUi 25888.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000270617 ; ENSP00000270617 ; ENSG00000142528 .
    ENST00000391821 ; ENSP00000375697 ; ENSG00000142528 .
    ENST00000595661 ; ENSP00000472808 ; ENSG00000142528 .
    GeneIDi 25888.
    KEGGi hsa:25888.
    UCSCi uc002prm.3. human.

    Organism-specific databases

    CTDi 25888.
    GeneCardsi GC19P050529.
    HGNCi HGNC:23239. ZNF473.
    HPAi HPA004191.
    neXtProti NX_Q8WTR7.
    PharmGKBi PA134987987.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000234617.
    HOVERGENi HBG018163.
    InParanoidi Q8WTR7.
    KOi K09228.
    OMAi CAECKET.
    OrthoDBi EOG7KSX7Q.
    PhylomeDBi Q8WTR7.
    TreeFami TF350932.

    Enzyme and pathway databases

    Reactomei REACT_12627. Generic Transcription Pathway.
    REACT_1364. SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs.
    REACT_185. SLBP independent Processing of Histone Pre-mRNAs.

    Miscellaneous databases

    EvolutionaryTracei Q8WTR7.
    GeneWikii ZNF473.
    GenomeRNAii 25888.
    NextBioi 47312.
    PROi Q8WTR7.

    Gene expression databases

    ArrayExpressi Q8WTR7.
    Bgeei Q8WTR7.
    CleanExi HS_ZNF473.
    Genevestigatori Q8WTR7.

    Family and domain databases

    Gene3Di 3.30.160.60. 21 hits.
    InterProi IPR001909. Krueppel-associated_box.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF01352. KRAB. 1 hit.
    PF00096. zf-C2H2. 3 hits.
    [Graphical view ]
    SMARTi SM00349. KRAB. 1 hit.
    SM00355. ZnF_C2H2. 20 hits.
    [Graphical view ]
    SUPFAMi SSF109640. SSF109640. 1 hit.
    PROSITEi PS50805. KRAB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 18 hits.
    PS50157. ZINC_FINGER_C2H2_2. 20 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel zinc finger protein is associated with U7 snRNP and interacts with the stem-loop binding protein in the histone pre-mRNP to stimulate 3'-end processing."
      Dominski Z., Erkmann J.A., Yang X., Sanchez R., Marzluff W.F.
      Genes Dev. 16:58-71(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH SLBP/PRE-MRNA COMPLEX.
    2. "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain."
      Hirosawa M., Nagase T., Ishikawa K., Kikuno R., Nomura N., Ohara O.
      DNA Res. 6:329-336(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 486-871.
      Tissue: Testis.
    7. "Unique Sm core structure of U7 snRNPs: assembly by a specialized SMN complex and the role of a new component, Lsm11, in histone RNA processing."
      Pillai R.S., Grimmler M., Meister G., Will C.L., Luehrmann R., Fischer U., Schuemperli D.
      Genes Dev. 17:2321-2333(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH LSM11.
      Tissue: Cervix carcinoma.
    8. "U7 snRNP-specific Lsm11 protein: dual binding contacts with the 100 kDa zinc finger processing factor (ZFP100) and a ZFP100-independent function in histone RNA 3'-end processing."
      Azzouz T.N., Gruber A., Schuemperli D.
      Nucleic Acids Res. 33:2106-2117(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH LSM11.
    9. "ZFP100, a component of the active U7 snRNP limiting for histone pre-mRNA processing, is required for entry into S phase."
      Wagner E.J., Marzluff W.F.
      Mol. Cell. Biol. 26:6702-6712(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    10. "Conserved zinc fingers mediate multiple functions of ZFP100, a U7snRNP associated protein."
      Wagner E.J., Ospina J.K., Hu Y., Dundr M., Matera A.G., Marzluff W.F.
      RNA 12:1206-1218(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH LSM11, SUBCELLULAR LOCATION.
    11. "Solution structure of the C2H2 type zinc finger region of human zinc finger protein 473."
      RIKEN structural genomics initiative (RSGI)
      Submitted (OCT-2007) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 205-841.

    Entry informationi

    Entry nameiZN473_HUMAN
    AccessioniPrimary (citable) accession number: Q8WTR7
    Secondary accession number(s): A8K8T7, Q9ULS9, Q9Y4Q7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 31, 2004
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3