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Q8WTR2

- DUS19_HUMAN

UniProt

Q8WTR2 - DUS19_HUMAN

Protein

Dual specificity protein phosphatase 19

Gene

DUSP19

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Has a dual specificity toward Ser/Thr and Tyr-containing proteins.1 Publication

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei150 – 1501Phosphocysteine intermediateBy similarity

    GO - Molecular functioni

    1. JUN kinase phosphatase activity Source: RefGenome
    2. MAP-kinase scaffold activity Source: BHF-UCL
    3. mitogen-activated protein kinase kinase kinase binding Source: BHF-UCL
    4. protein kinase activator activity Source: BHF-UCL
    5. protein kinase inhibitor activity Source: BHF-UCL
    6. protein tyrosine/threonine phosphatase activity Source: Ensembl
    7. protein tyrosine phosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. inactivation of MAPK activity Source: Ensembl
    2. JNK cascade Source: RefGenome
    3. negative regulation of JNK cascade Source: BHF-UCL
    4. negative regulation of JUN kinase activity Source: BHF-UCL
    5. negative regulation of protein kinase activity Source: BHF-UCL
    6. positive regulation of JNK cascade Source: BHF-UCL
    7. positive regulation of JUN kinase activity Source: BHF-UCL
    8. positive regulation of MAPK cascade Source: BHF-UCL
    9. positive regulation of protein kinase activity Source: BHF-UCL
    10. protein dephosphorylation Source: RefGenome

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Enzyme and pathway databases

    SignaLinkiQ8WTR2.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dual specificity protein phosphatase 19 (EC:3.1.3.16, EC:3.1.3.48)
    Alternative name(s):
    Dual specificity phosphatase TS-DSP1
    Low molecular weight dual specificity phosphatase 3
    Short name:
    LMW-DSP3
    Protein phosphatase SKRP1
    Stress-activated protein kinase pathway-regulating phosphatase 1
    Short name:
    SAPK pathway-regulating phosphatase 1
    Gene namesi
    Name:DUSP19
    Synonyms:DUSP17, LMWDSP3, SKRP1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:18894. DUSP19.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134895660.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 217217Dual specificity protein phosphatase 19PRO_0000094832Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ8WTR2.
    PaxDbiQ8WTR2.
    PRIDEiQ8WTR2.

    PTM databases

    PhosphoSiteiQ8WTR2.

    Expressioni

    Tissue specificityi

    Expressed in the heart, lung, liver, and pancreas. The expression level in the pancreas is the highest.1 Publication

    Gene expression databases

    BgeeiQ8WTR2.
    CleanExiHS_DUSP19.
    GenevestigatoriQ8WTR2.

    Organism-specific databases

    HPAiHPA021501.

    Interactioni

    Protein-protein interaction databases

    BioGridi126770. 4 interactions.
    IntActiQ8WTR2. 1 interaction.
    STRINGi9606.ENSP00000346160.

    Structurei

    Secondary structure

    1
    217
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi67 – 704
    Beta strandi73 – 764
    Helixi78 – 814
    Helixi84 – 896
    Beta strandi94 – 974
    Beta strandi99 – 1013
    Turni107 – 1093
    Beta strandi110 – 1145
    Helixi125 – 1284
    Helixi129 – 14113
    Beta strandi146 – 1494
    Beta strandi151 – 1555
    Helixi156 – 16914
    Helixi173 – 18311
    Helixi191 – 1999
    Helixi202 – 2054

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3S4EX-ray1.26A65-206[»]
    ProteinModelPortaliQ8WTR2.
    SMRiQ8WTR2. Positions 65-206.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini133 – 19765Tyrosine-protein phosphataseAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG2453.
    HOGENOMiHOG000233765.
    HOVERGENiHBG051424.
    InParanoidiQ8WTR2.
    KOiK14165.
    OMAiMEQLRTY.
    OrthoDBiEOG72JWHW.
    PhylomeDBiQ8WTR2.
    TreeFamiTF354211.

    Family and domain databases

    Gene3Di3.90.190.10. 1 hit.
    InterProiIPR020417. Atypical_DUSP.
    IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    [Graphical view]
    PANTHERiPTHR10159. PTHR10159. 1 hit.
    PfamiPF00782. DSPc. 1 hit.
    [Graphical view]
    PRINTSiPR01908. ADSPHPHTASE.
    SMARTiSM00195. DSPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    PROSITEiPS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8WTR2-1) [UniParc]FASTAAdd to Basket

    Also known as: Long

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MYSLNQEIKA FSRNNLRKQC TRVTTLTGKK IIETWKDARI HVVEEVEPSS    50
    GGGCGYVQDL SSDLQVGVIK PWLLLGSQDA AHDLDTLKKN KVTHILNVAY 100
    GVENAFLSDF TYKSISILDL PETNILSYFP ECFEFIEEAK RKDGVVLVHC 150
    NAGVSRAAAI VIGFLMNSEQ TSFTSAFSLV KNARPSICPN SGFMEQLRTY 200
    QEGKESNKCD RIQENSS 217
    Length:217
    Mass (Da):24,194
    Last modified:March 1, 2002 - v1
    Checksum:iA9FAB082D35EC442
    GO
    Isoform 2 (identifier: Q8WTR2-2) [UniParc]FASTAAdd to Basket

    Also known as: Short

    The sequence of this isoform differs from the canonical sequence as follows:
         91-141: Missing.

    Show »
    Length:166
    Mass (Da):18,296
    Checksum:i76E894A1DF10E70F
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti216 – 2161S → R.
    Corresponds to variant rs16823987 [ dbSNP | Ensembl ].
    VAR_051755

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei91 – 14151Missing in isoform 2. 1 PublicationVSP_005138Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB063186 mRNA. Translation: BAB83498.1.
    AB063187 mRNA. Translation: BAB83499.1.
    AB038770 mRNA. Translation: BAB82499.1.
    AF486808 mRNA. Translation: AAO49450.1.
    AK314078 mRNA. Translation: BAG36776.1.
    AC064871 Genomic DNA. Translation: AAY24197.1.
    BC035000 mRNA. Translation: AAH35000.1.
    BC093958 mRNA. Translation: AAH93958.1.
    BC112005 mRNA. Translation: AAI12006.1.
    CCDSiCCDS2289.1. [Q8WTR2-1]
    CCDS46469.1. [Q8WTR2-2]
    RefSeqiNP_001135786.1. NM_001142314.1. [Q8WTR2-2]
    NP_543152.1. NM_080876.3. [Q8WTR2-1]
    UniGeneiHs.132237.

    Genome annotation databases

    EnsembliENST00000342619; ENSP00000343905; ENSG00000162999. [Q8WTR2-2]
    ENST00000354221; ENSP00000346160; ENSG00000162999. [Q8WTR2-1]
    GeneIDi142679.
    KEGGihsa:142679.
    UCSCiuc002upd.3. human. [Q8WTR2-1]
    uc002upe.3. human. [Q8WTR2-2]

    Polymorphism databases

    DMDMi29840769.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB063186 mRNA. Translation: BAB83498.1 .
    AB063187 mRNA. Translation: BAB83499.1 .
    AB038770 mRNA. Translation: BAB82499.1 .
    AF486808 mRNA. Translation: AAO49450.1 .
    AK314078 mRNA. Translation: BAG36776.1 .
    AC064871 Genomic DNA. Translation: AAY24197.1 .
    BC035000 mRNA. Translation: AAH35000.1 .
    BC093958 mRNA. Translation: AAH93958.1 .
    BC112005 mRNA. Translation: AAI12006.1 .
    CCDSi CCDS2289.1. [Q8WTR2-1 ]
    CCDS46469.1. [Q8WTR2-2 ]
    RefSeqi NP_001135786.1. NM_001142314.1. [Q8WTR2-2 ]
    NP_543152.1. NM_080876.3. [Q8WTR2-1 ]
    UniGenei Hs.132237.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3S4E X-ray 1.26 A 65-206 [» ]
    ProteinModelPortali Q8WTR2.
    SMRi Q8WTR2. Positions 65-206.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 126770. 4 interactions.
    IntActi Q8WTR2. 1 interaction.
    STRINGi 9606.ENSP00000346160.

    PTM databases

    PhosphoSitei Q8WTR2.

    Polymorphism databases

    DMDMi 29840769.

    Proteomic databases

    MaxQBi Q8WTR2.
    PaxDbi Q8WTR2.
    PRIDEi Q8WTR2.

    Protocols and materials databases

    DNASUi 142679.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000342619 ; ENSP00000343905 ; ENSG00000162999 . [Q8WTR2-2 ]
    ENST00000354221 ; ENSP00000346160 ; ENSG00000162999 . [Q8WTR2-1 ]
    GeneIDi 142679.
    KEGGi hsa:142679.
    UCSCi uc002upd.3. human. [Q8WTR2-1 ]
    uc002upe.3. human. [Q8WTR2-2 ]

    Organism-specific databases

    CTDi 142679.
    GeneCardsi GC02P183907.
    HGNCi HGNC:18894. DUSP19.
    HPAi HPA021501.
    MIMi 611437. gene.
    neXtProti NX_Q8WTR2.
    PharmGKBi PA134895660.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2453.
    HOGENOMi HOG000233765.
    HOVERGENi HBG051424.
    InParanoidi Q8WTR2.
    KOi K14165.
    OMAi MEQLRTY.
    OrthoDBi EOG72JWHW.
    PhylomeDBi Q8WTR2.
    TreeFami TF354211.

    Enzyme and pathway databases

    SignaLinki Q8WTR2.

    Miscellaneous databases

    GeneWikii DUSP19.
    GenomeRNAii 142679.
    NextBioi 84595.
    PROi Q8WTR2.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8WTR2.
    CleanExi HS_DUSP19.
    Genevestigatori Q8WTR2.

    Family and domain databases

    Gene3Di 3.90.190.10. 1 hit.
    InterProi IPR020417. Atypical_DUSP.
    IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    [Graphical view ]
    PANTHERi PTHR10159. PTHR10159. 1 hit.
    Pfami PF00782. DSPc. 1 hit.
    [Graphical view ]
    PRINTSi PR01908. ADSPHPHTASE.
    SMARTi SM00195. DSPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    PROSITEi PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Scaffold role of a mitogen-activated protein kinase phosphatase, SKRP1, for the JNK signaling pathway."
      Zama T., Aoki R., Kamimoto T., Inoue K., Ikeda Y., Hagiwara M.
      J. Biol. Chem. 277:23919-23926(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
    2. Kikuchi K., Nakamura K., Sato T., Shima H.
      Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "Molecular cloning and characterization of a novel human protein phosphatase, LMW-DSP3."
      Cheng H., Gao Q., Jiang M., Ma Y., Ni X., Guo L., Jin W., Cao G., Ji C., Ying K., Xu W., Gu S., Ma Y., Xie Y., Mao Y.
      Int. J. Biochem. Cell Biol. 35:226-234(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Uterus.
    5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Liver and Testis.
    7. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. "Crystal structure of a novel mitogen-activated protein kinase phosphatase, SKRP1."
      Wei C.H., Ryu S.Y., Jeon Y.H., Yoon M.Y., Jeong D.G., Kim S.J., Ryu S.E.
      Proteins 79:3242-3246(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.26 ANGSTROMS) OF 65-206.

    Entry informationi

    Entry nameiDUS19_HUMAN
    AccessioniPrimary (citable) accession number: Q8WTR2
    Secondary accession number(s): B2RA79, Q547H4, Q8WYN4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 28, 2003
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3