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Q8WTR2

- DUS19_HUMAN

UniProt

Q8WTR2 - DUS19_HUMAN

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Protein

Dual specificity protein phosphatase 19

Gene

DUSP19

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Has a dual specificity toward Ser/Thr and Tyr-containing proteins.1 Publication

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei150 – 1501Phosphocysteine intermediateBy similarity

GO - Molecular functioni

  1. JUN kinase phosphatase activity Source: RefGenome
  2. MAP-kinase scaffold activity Source: BHF-UCL
  3. mitogen-activated protein kinase kinase kinase binding Source: BHF-UCL
  4. protein kinase activator activity Source: BHF-UCL
  5. protein kinase inhibitor activity Source: BHF-UCL
  6. protein tyrosine/threonine phosphatase activity Source: Ensembl
  7. protein tyrosine phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. inactivation of MAPK activity Source: Ensembl
  2. JNK cascade Source: RefGenome
  3. negative regulation of JNK cascade Source: BHF-UCL
  4. negative regulation of JUN kinase activity Source: BHF-UCL
  5. negative regulation of protein kinase activity Source: BHF-UCL
  6. positive regulation of JNK cascade Source: BHF-UCL
  7. positive regulation of JUN kinase activity Source: BHF-UCL
  8. positive regulation of MAPK cascade Source: BHF-UCL
  9. positive regulation of protein kinase activity Source: BHF-UCL
  10. protein dephosphorylation Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Enzyme and pathway databases

SignaLinkiQ8WTR2.

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity protein phosphatase 19 (EC:3.1.3.16, EC:3.1.3.48)
Alternative name(s):
Dual specificity phosphatase TS-DSP1
Low molecular weight dual specificity phosphatase 3
Short name:
LMW-DSP3
Protein phosphatase SKRP1
Stress-activated protein kinase pathway-regulating phosphatase 1
Short name:
SAPK pathway-regulating phosphatase 1
Gene namesi
Name:DUSP19
Synonyms:DUSP17, LMWDSP3, SKRP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:18894. DUSP19.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134895660.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 217217Dual specificity protein phosphatase 19PRO_0000094832Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ8WTR2.
PaxDbiQ8WTR2.
PRIDEiQ8WTR2.

PTM databases

PhosphoSiteiQ8WTR2.

Expressioni

Tissue specificityi

Expressed in the heart, lung, liver, and pancreas. The expression level in the pancreas is the highest.1 Publication

Gene expression databases

BgeeiQ8WTR2.
CleanExiHS_DUSP19.
GenevestigatoriQ8WTR2.

Organism-specific databases

HPAiHPA021501.

Interactioni

Protein-protein interaction databases

BioGridi126770. 13 interactions.
IntActiQ8WTR2. 1 interaction.
STRINGi9606.ENSP00000346160.

Structurei

Secondary structure

1
217
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi67 – 704Combined sources
Beta strandi73 – 764Combined sources
Helixi78 – 814Combined sources
Helixi84 – 896Combined sources
Beta strandi94 – 974Combined sources
Beta strandi99 – 1013Combined sources
Turni107 – 1093Combined sources
Beta strandi110 – 1145Combined sources
Helixi125 – 1284Combined sources
Helixi129 – 14113Combined sources
Beta strandi146 – 1494Combined sources
Beta strandi151 – 1555Combined sources
Helixi156 – 16914Combined sources
Helixi173 – 18311Combined sources
Helixi191 – 1999Combined sources
Helixi202 – 2054Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3S4EX-ray1.26A65-206[»]
ProteinModelPortaliQ8WTR2.
SMRiQ8WTR2. Positions 65-206.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini133 – 19765Tyrosine-protein phosphataseAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2453.
GeneTreeiENSGT00760000118853.
HOGENOMiHOG000233765.
HOVERGENiHBG051424.
InParanoidiQ8WTR2.
KOiK14165.
OMAiMEQLRTY.
OrthoDBiEOG72JWHW.
PhylomeDBiQ8WTR2.
TreeFamiTF354211.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR020417. Atypical_DUSP.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
PRINTSiPR01908. ADSPHPHTASE.
SMARTiSM00195. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8WTR2-1) [UniParc]FASTAAdd to Basket

Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYSLNQEIKA FSRNNLRKQC TRVTTLTGKK IIETWKDARI HVVEEVEPSS
60 70 80 90 100
GGGCGYVQDL SSDLQVGVIK PWLLLGSQDA AHDLDTLKKN KVTHILNVAY
110 120 130 140 150
GVENAFLSDF TYKSISILDL PETNILSYFP ECFEFIEEAK RKDGVVLVHC
160 170 180 190 200
NAGVSRAAAI VIGFLMNSEQ TSFTSAFSLV KNARPSICPN SGFMEQLRTY
210
QEGKESNKCD RIQENSS
Length:217
Mass (Da):24,194
Last modified:March 1, 2002 - v1
Checksum:iA9FAB082D35EC442
GO
Isoform 2 (identifier: Q8WTR2-2) [UniParc]FASTAAdd to Basket

Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     91-141: Missing.

Show »
Length:166
Mass (Da):18,296
Checksum:i76E894A1DF10E70F
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti216 – 2161S → R.
Corresponds to variant rs16823987 [ dbSNP | Ensembl ].
VAR_051755

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei91 – 14151Missing in isoform 2. 1 PublicationVSP_005138Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB063186 mRNA. Translation: BAB83498.1.
AB063187 mRNA. Translation: BAB83499.1.
AB038770 mRNA. Translation: BAB82499.1.
AF486808 mRNA. Translation: AAO49450.1.
AK314078 mRNA. Translation: BAG36776.1.
AC064871 Genomic DNA. Translation: AAY24197.1.
BC035000 mRNA. Translation: AAH35000.1.
BC093958 mRNA. Translation: AAH93958.1.
BC112005 mRNA. Translation: AAI12006.1.
CCDSiCCDS2289.1. [Q8WTR2-1]
CCDS46469.1. [Q8WTR2-2]
RefSeqiNP_001135786.1. NM_001142314.1. [Q8WTR2-2]
NP_543152.1. NM_080876.3. [Q8WTR2-1]
UniGeneiHs.132237.

Genome annotation databases

EnsembliENST00000342619; ENSP00000343905; ENSG00000162999. [Q8WTR2-2]
ENST00000354221; ENSP00000346160; ENSG00000162999. [Q8WTR2-1]
GeneIDi142679.
KEGGihsa:142679.
UCSCiuc002upd.3. human. [Q8WTR2-1]
uc002upe.3. human. [Q8WTR2-2]

Polymorphism databases

DMDMi29840769.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB063186 mRNA. Translation: BAB83498.1 .
AB063187 mRNA. Translation: BAB83499.1 .
AB038770 mRNA. Translation: BAB82499.1 .
AF486808 mRNA. Translation: AAO49450.1 .
AK314078 mRNA. Translation: BAG36776.1 .
AC064871 Genomic DNA. Translation: AAY24197.1 .
BC035000 mRNA. Translation: AAH35000.1 .
BC093958 mRNA. Translation: AAH93958.1 .
BC112005 mRNA. Translation: AAI12006.1 .
CCDSi CCDS2289.1. [Q8WTR2-1 ]
CCDS46469.1. [Q8WTR2-2 ]
RefSeqi NP_001135786.1. NM_001142314.1. [Q8WTR2-2 ]
NP_543152.1. NM_080876.3. [Q8WTR2-1 ]
UniGenei Hs.132237.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3S4E X-ray 1.26 A 65-206 [» ]
ProteinModelPortali Q8WTR2.
SMRi Q8WTR2. Positions 65-206.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 126770. 13 interactions.
IntActi Q8WTR2. 1 interaction.
STRINGi 9606.ENSP00000346160.

PTM databases

PhosphoSitei Q8WTR2.

Polymorphism databases

DMDMi 29840769.

Proteomic databases

MaxQBi Q8WTR2.
PaxDbi Q8WTR2.
PRIDEi Q8WTR2.

Protocols and materials databases

DNASUi 142679.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000342619 ; ENSP00000343905 ; ENSG00000162999 . [Q8WTR2-2 ]
ENST00000354221 ; ENSP00000346160 ; ENSG00000162999 . [Q8WTR2-1 ]
GeneIDi 142679.
KEGGi hsa:142679.
UCSCi uc002upd.3. human. [Q8WTR2-1 ]
uc002upe.3. human. [Q8WTR2-2 ]

Organism-specific databases

CTDi 142679.
GeneCardsi GC02P183907.
HGNCi HGNC:18894. DUSP19.
HPAi HPA021501.
MIMi 611437. gene.
neXtProti NX_Q8WTR2.
PharmGKBi PA134895660.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2453.
GeneTreei ENSGT00760000118853.
HOGENOMi HOG000233765.
HOVERGENi HBG051424.
InParanoidi Q8WTR2.
KOi K14165.
OMAi MEQLRTY.
OrthoDBi EOG72JWHW.
PhylomeDBi Q8WTR2.
TreeFami TF354211.

Enzyme and pathway databases

SignaLinki Q8WTR2.

Miscellaneous databases

GeneWikii DUSP19.
GenomeRNAii 142679.
NextBioi 84595.
PROi Q8WTR2.
SOURCEi Search...

Gene expression databases

Bgeei Q8WTR2.
CleanExi HS_DUSP19.
Genevestigatori Q8WTR2.

Family and domain databases

Gene3Di 3.90.190.10. 1 hit.
InterProi IPR020417. Atypical_DUSP.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
[Graphical view ]
PANTHERi PTHR10159. PTHR10159. 1 hit.
Pfami PF00782. DSPc. 1 hit.
[Graphical view ]
PRINTSi PR01908. ADSPHPHTASE.
SMARTi SM00195. DSPc. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 1 hit.
PROSITEi PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Scaffold role of a mitogen-activated protein kinase phosphatase, SKRP1, for the JNK signaling pathway."
    Zama T., Aoki R., Kamimoto T., Inoue K., Ikeda Y., Hagiwara M.
    J. Biol. Chem. 277:23919-23926(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
  2. Kikuchi K., Nakamura K., Sato T., Shima H.
    Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Molecular cloning and characterization of a novel human protein phosphatase, LMW-DSP3."
    Cheng H., Gao Q., Jiang M., Ma Y., Ni X., Guo L., Jin W., Cao G., Ji C., Ying K., Xu W., Gu S., Ma Y., Xie Y., Mao Y.
    Int. J. Biochem. Cell Biol. 35:226-234(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Uterus.
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Liver and Testis.
  7. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Crystal structure of a novel mitogen-activated protein kinase phosphatase, SKRP1."
    Wei C.H., Ryu S.Y., Jeon Y.H., Yoon M.Y., Jeong D.G., Kim S.J., Ryu S.E.
    Proteins 79:3242-3246(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.26 ANGSTROMS) OF 65-206.

Entry informationi

Entry nameiDUS19_HUMAN
AccessioniPrimary (citable) accession number: Q8WTR2
Secondary accession number(s): B2RA79, Q547H4, Q8WYN4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: March 1, 2002
Last modified: November 26, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3