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Q8WTR2 (DUS19_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dual specificity protein phosphatase 19

EC=3.1.3.16
EC=3.1.3.48
Alternative name(s):
Dual specificity phosphatase TS-DSP1
Low molecular weight dual specificity phosphatase 3
Short name=LMW-DSP3
Protein phosphatase SKRP1
Stress-activated protein kinase pathway-regulating phosphatase 1
Short name=SAPK pathway-regulating phosphatase 1
Gene names
Name:DUSP19
Synonyms:DUSP17, LMWDSP3, SKRP1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length217 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Has a dual specificity toward Ser/Thr and Tyr-containing proteins. Ref.3

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Tissue specificity

Expressed in the heart, lung, liver, and pancreas. The expression level in the pancreas is the highest. Ref.3

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

Contains 1 tyrosine-protein phosphatase domain.

Ontologies

Keywords
   Coding sequence diversityAlternative splicing
Polymorphism
   Molecular functionHydrolase
Protein phosphatase
   PTMAcetylation
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processJNK cascade

Inferred from Biological aspect of Ancestor. Source: RefGenome

inactivation of MAPK activity

Inferred from electronic annotation. Source: Ensembl

negative regulation of JNK cascade

Inferred from sequence or structural similarity. Source: BHF-UCL

negative regulation of JUN kinase activity

Inferred from sequence or structural similarity. Source: BHF-UCL

negative regulation of protein kinase activity

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of JNK cascade

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of JUN kinase activity

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of MAPK cascade

Inferred from sequence or structural similarity. Source: BHF-UCL

positive regulation of protein kinase activity

Inferred from sequence or structural similarity. Source: BHF-UCL

protein dephosphorylation

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Cellular_componentcytoplasm

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Molecular_functionJUN kinase phosphatase activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

MAP-kinase scaffold activity

Inferred from sequence or structural similarity. Source: BHF-UCL

mitogen-activated protein kinase kinase kinase binding

Inferred from sequence or structural similarity. Source: BHF-UCL

protein kinase activator activity

Inferred from sequence or structural similarity. Source: BHF-UCL

protein kinase inhibitor activity

Inferred from sequence or structural similarity. Source: BHF-UCL

protein tyrosine phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

protein tyrosine/threonine phosphatase activity

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8WTR2-1)

Also known as: Long;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8WTR2-2)

Also known as: Short;

The sequence of this isoform differs from the canonical sequence as follows:
     91-141: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 217217Dual specificity protein phosphatase 19
PRO_0000094832

Regions

Domain133 – 19765Tyrosine-protein phosphatase

Sites

Active site1501Phosphocysteine intermediate By similarity

Amino acid modifications

Modified residue11N-acetylmethionine Ref.7

Natural variations

Alternative sequence91 – 14151Missing in isoform 2.
VSP_005138
Natural variant2161S → R.
Corresponds to variant rs16823987 [ dbSNP | Ensembl ].
VAR_051755

Secondary structure

.............................. 217
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (Long) [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: A9FAB082D35EC442

FASTA21724,194
        10         20         30         40         50         60 
MYSLNQEIKA FSRNNLRKQC TRVTTLTGKK IIETWKDARI HVVEEVEPSS GGGCGYVQDL 

        70         80         90        100        110        120 
SSDLQVGVIK PWLLLGSQDA AHDLDTLKKN KVTHILNVAY GVENAFLSDF TYKSISILDL 

       130        140        150        160        170        180 
PETNILSYFP ECFEFIEEAK RKDGVVLVHC NAGVSRAAAI VIGFLMNSEQ TSFTSAFSLV 

       190        200        210 
KNARPSICPN SGFMEQLRTY QEGKESNKCD RIQENSS 

« Hide

Isoform 2 (Short) [UniParc].

Checksum: 76E894A1DF10E70F
Show »

FASTA16618,296

References

« Hide 'large scale' references
[1]"Scaffold role of a mitogen-activated protein kinase phosphatase, SKRP1, for the JNK signaling pathway."
Zama T., Aoki R., Kamimoto T., Inoue K., Ikeda Y., Hagiwara M.
J. Biol. Chem. 277:23919-23926(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
[2]Kikuchi K., Nakamura K., Sato T., Shima H.
Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]"Molecular cloning and characterization of a novel human protein phosphatase, LMW-DSP3."
Cheng H., Gao Q., Jiang M., Ma Y., Ni X., Guo L., Jin W., Cao G., Ji C., Ying K., Xu W., Gu S., Ma Y., Xie Y., Mao Y.
Int. J. Biochem. Cell Biol. 35:226-234(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Uterus.
[5]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Liver and Testis.
[7]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[8]"Crystal structure of a novel mitogen-activated protein kinase phosphatase, SKRP1."
Wei C.H., Ryu S.Y., Jeon Y.H., Yoon M.Y., Jeong D.G., Kim S.J., Ryu S.E.
Proteins 79:3242-3246(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.26 ANGSTROMS) OF 65-206.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB063186 mRNA. Translation: BAB83498.1.
AB063187 mRNA. Translation: BAB83499.1.
AB038770 mRNA. Translation: BAB82499.1.
AF486808 mRNA. Translation: AAO49450.1.
AK314078 mRNA. Translation: BAG36776.1.
AC064871 Genomic DNA. Translation: AAY24197.1.
BC035000 mRNA. Translation: AAH35000.1.
BC093958 mRNA. Translation: AAH93958.1.
BC112005 mRNA. Translation: AAI12006.1.
RefSeqNP_001135786.1. NM_001142314.1.
NP_543152.1. NM_080876.3.
UniGeneHs.132237.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3S4EX-ray1.26A65-206[»]
ProteinModelPortalQ8WTR2.
SMRQ8WTR2. Positions 65-206.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid126770. 4 interactions.
IntActQ8WTR2. 1 interaction.
STRING9606.ENSP00000346160.

PTM databases

PhosphoSiteQ8WTR2.

Polymorphism databases

DMDM29840769.

Proteomic databases

PaxDbQ8WTR2.
PRIDEQ8WTR2.

Protocols and materials databases

DNASU142679.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000342619; ENSP00000343905; ENSG00000162999. [Q8WTR2-2]
ENST00000354221; ENSP00000346160; ENSG00000162999. [Q8WTR2-1]
GeneID142679.
KEGGhsa:142679.
UCSCuc002upd.3. human. [Q8WTR2-1]
uc002upe.3. human. [Q8WTR2-2]

Organism-specific databases

CTD142679.
GeneCardsGC02P183907.
HGNCHGNC:18894. DUSP19.
HPAHPA021501.
MIM611437. gene.
neXtProtNX_Q8WTR2.
PharmGKBPA134895660.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG2453.
HOGENOMHOG000233765.
HOVERGENHBG051424.
InParanoidQ8WTR2.
KOK14165.
OMAMEQLRTY.
OrthoDBEOG72JWHW.
PhylomeDBQ8WTR2.
TreeFamTF354211.

Enzyme and pathway databases

SignaLinkQ8WTR2.

Gene expression databases

BgeeQ8WTR2.
CleanExHS_DUSP19.
GenevestigatorQ8WTR2.

Family and domain databases

InterProIPR020417. Atypical_DUSP.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR000387. Tyr/Dual-sp_Pase.
[Graphical view]
PANTHERPTHR10159. PTHR10159. 1 hit.
PfamPF00782. DSPc. 1 hit.
[Graphical view]
PRINTSPR01908. ADSPHPHTASE.
SMARTSM00195. DSPc. 1 hit.
[Graphical view]
PROSITEPS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiDUSP19.
GenomeRNAi142679.
NextBio84595.
PROQ8WTR2.
SOURCESearch...

Entry information

Entry nameDUS19_HUMAN
AccessionPrimary (citable) accession number: Q8WTR2
Secondary accession number(s): B2RA79, Q547H4, Q8WYN4
Entry history
Integrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: March 1, 2002
Last modified: April 16, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM