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Protein

Dual specificity protein phosphatase 19

Gene

DUSP19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Has a dual specificity toward Ser/Thr and Tyr-containing proteins.1 Publication

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei150Phosphocysteine intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Enzyme and pathway databases

BioCyciZFISH:HS08771-MONOMER.
SignaLinkiQ8WTR2.
SIGNORiQ8WTR2.

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity protein phosphatase 19 (EC:3.1.3.16, EC:3.1.3.48)
Alternative name(s):
Dual specificity phosphatase TS-DSP1
Low molecular weight dual specificity phosphatase 3
Short name:
LMW-DSP3
Protein phosphatase SKRP1
Stress-activated protein kinase pathway-regulating phosphatase 1
Short name:
SAPK pathway-regulating phosphatase 1
Gene namesi
Name:DUSP19
Synonyms:DUSP17, LMWDSP3, SKRP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:18894. DUSP19.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000162999.
PharmGKBiPA134895660.

Polymorphism and mutation databases

BioMutaiDUSP19.
DMDMi29840769.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000948321 – 217Dual specificity protein phosphatase 19Add BLAST217

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ8WTR2.
MaxQBiQ8WTR2.
PaxDbiQ8WTR2.
PeptideAtlasiQ8WTR2.
PRIDEiQ8WTR2.

PTM databases

DEPODiQ8WTR2.
iPTMnetiQ8WTR2.
PhosphoSitePlusiQ8WTR2.

Expressioni

Tissue specificityi

Expressed in the heart, lung, liver, and pancreas. The expression level in the pancreas is the highest.1 Publication

Gene expression databases

BgeeiENSG00000162999.
CleanExiHS_DUSP19.
GenevisibleiQ8WTR2. HS.

Organism-specific databases

HPAiHPA021501.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ALAS1P131966EBI-8654968,EBI-3905054

GO - Molecular functioni

Protein-protein interaction databases

BioGridi126770. 14 interactors.
IntActiQ8WTR2. 1 interactor.
STRINGi9606.ENSP00000346160.

Structurei

Secondary structure

1217
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi67 – 70Combined sources4
Beta strandi73 – 76Combined sources4
Helixi78 – 81Combined sources4
Helixi84 – 89Combined sources6
Beta strandi94 – 97Combined sources4
Beta strandi99 – 101Combined sources3
Turni107 – 109Combined sources3
Beta strandi110 – 114Combined sources5
Helixi125 – 128Combined sources4
Helixi129 – 141Combined sources13
Beta strandi146 – 149Combined sources4
Beta strandi151 – 155Combined sources5
Helixi156 – 169Combined sources14
Helixi173 – 183Combined sources11
Helixi191 – 199Combined sources9
Helixi202 – 205Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3S4EX-ray1.26A65-206[»]
4D3PX-ray1.27A65-205[»]
4D3QX-ray1.64A/B65-205[»]
4D3RX-ray1.67A65-204[»]
ProteinModelPortaliQ8WTR2.
SMRiQ8WTR2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini133 – 197Tyrosine-protein phosphataseAdd BLAST65

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1716. Eukaryota.
COG2453. LUCA.
GeneTreeiENSGT00760000118853.
HOGENOMiHOG000233765.
HOVERGENiHBG051424.
InParanoidiQ8WTR2.
KOiK14165.
OMAiYQEVKES.
OrthoDBiEOG091G0249.
PhylomeDBiQ8WTR2.
TreeFamiTF354211.

Family and domain databases

CDDicd00127. DSPc. 1 hit.
Gene3Di3.90.190.10. 1 hit.
InterProiIPR020417. Atypical_DUSP.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. TYR_PHOSPHATASE_dom.
IPR020422. TYR_PHOSPHATASE_DUAL_dom.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
PRINTSiPR01908. ADSPHPHTASE.
SMARTiSM00195. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8WTR2-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYSLNQEIKA FSRNNLRKQC TRVTTLTGKK IIETWKDARI HVVEEVEPSS
60 70 80 90 100
GGGCGYVQDL SSDLQVGVIK PWLLLGSQDA AHDLDTLKKN KVTHILNVAY
110 120 130 140 150
GVENAFLSDF TYKSISILDL PETNILSYFP ECFEFIEEAK RKDGVVLVHC
160 170 180 190 200
NAGVSRAAAI VIGFLMNSEQ TSFTSAFSLV KNARPSICPN SGFMEQLRTY
210
QEGKESNKCD RIQENSS
Length:217
Mass (Da):24,194
Last modified:March 1, 2002 - v1
Checksum:iA9FAB082D35EC442
GO
Isoform 2 (identifier: Q8WTR2-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     91-141: Missing.

Show »
Length:166
Mass (Da):18,296
Checksum:i76E894A1DF10E70F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051755216S → R.Corresponds to variant rs16823987dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00513891 – 141Missing in isoform 2. 1 PublicationAdd BLAST51

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB063186 mRNA. Translation: BAB83498.1.
AB063187 mRNA. Translation: BAB83499.1.
AB038770 mRNA. Translation: BAB82499.1.
AF486808 mRNA. Translation: AAO49450.1.
AK314078 mRNA. Translation: BAG36776.1.
AC064871 Genomic DNA. Translation: AAY24197.1.
BC035000 mRNA. Translation: AAH35000.1.
BC093958 mRNA. Translation: AAH93958.1.
BC112005 mRNA. Translation: AAI12006.1.
CCDSiCCDS2289.1. [Q8WTR2-1]
CCDS46469.1. [Q8WTR2-2]
RefSeqiNP_001135786.1. NM_001142314.1. [Q8WTR2-2]
NP_001308448.1. NM_001321519.1.
NP_543152.1. NM_080876.3. [Q8WTR2-1]
UniGeneiHs.132237.

Genome annotation databases

EnsembliENST00000342619; ENSP00000343905; ENSG00000162999. [Q8WTR2-2]
ENST00000354221; ENSP00000346160; ENSG00000162999. [Q8WTR2-1]
GeneIDi142679.
KEGGihsa:142679.
UCSCiuc002upd.4. human. [Q8WTR2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB063186 mRNA. Translation: BAB83498.1.
AB063187 mRNA. Translation: BAB83499.1.
AB038770 mRNA. Translation: BAB82499.1.
AF486808 mRNA. Translation: AAO49450.1.
AK314078 mRNA. Translation: BAG36776.1.
AC064871 Genomic DNA. Translation: AAY24197.1.
BC035000 mRNA. Translation: AAH35000.1.
BC093958 mRNA. Translation: AAH93958.1.
BC112005 mRNA. Translation: AAI12006.1.
CCDSiCCDS2289.1. [Q8WTR2-1]
CCDS46469.1. [Q8WTR2-2]
RefSeqiNP_001135786.1. NM_001142314.1. [Q8WTR2-2]
NP_001308448.1. NM_001321519.1.
NP_543152.1. NM_080876.3. [Q8WTR2-1]
UniGeneiHs.132237.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3S4EX-ray1.26A65-206[»]
4D3PX-ray1.27A65-205[»]
4D3QX-ray1.64A/B65-205[»]
4D3RX-ray1.67A65-204[»]
ProteinModelPortaliQ8WTR2.
SMRiQ8WTR2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126770. 14 interactors.
IntActiQ8WTR2. 1 interactor.
STRINGi9606.ENSP00000346160.

PTM databases

DEPODiQ8WTR2.
iPTMnetiQ8WTR2.
PhosphoSitePlusiQ8WTR2.

Polymorphism and mutation databases

BioMutaiDUSP19.
DMDMi29840769.

Proteomic databases

EPDiQ8WTR2.
MaxQBiQ8WTR2.
PaxDbiQ8WTR2.
PeptideAtlasiQ8WTR2.
PRIDEiQ8WTR2.

Protocols and materials databases

DNASUi142679.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000342619; ENSP00000343905; ENSG00000162999. [Q8WTR2-2]
ENST00000354221; ENSP00000346160; ENSG00000162999. [Q8WTR2-1]
GeneIDi142679.
KEGGihsa:142679.
UCSCiuc002upd.4. human. [Q8WTR2-1]

Organism-specific databases

CTDi142679.
GeneCardsiDUSP19.
HGNCiHGNC:18894. DUSP19.
HPAiHPA021501.
MIMi611437. gene.
neXtProtiNX_Q8WTR2.
OpenTargetsiENSG00000162999.
PharmGKBiPA134895660.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1716. Eukaryota.
COG2453. LUCA.
GeneTreeiENSGT00760000118853.
HOGENOMiHOG000233765.
HOVERGENiHBG051424.
InParanoidiQ8WTR2.
KOiK14165.
OMAiYQEVKES.
OrthoDBiEOG091G0249.
PhylomeDBiQ8WTR2.
TreeFamiTF354211.

Enzyme and pathway databases

BioCyciZFISH:HS08771-MONOMER.
SignaLinkiQ8WTR2.
SIGNORiQ8WTR2.

Miscellaneous databases

GeneWikiiDUSP19.
GenomeRNAii142679.
PROiQ8WTR2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000162999.
CleanExiHS_DUSP19.
GenevisibleiQ8WTR2. HS.

Family and domain databases

CDDicd00127. DSPc. 1 hit.
Gene3Di3.90.190.10. 1 hit.
InterProiIPR020417. Atypical_DUSP.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. TYR_PHOSPHATASE_dom.
IPR020422. TYR_PHOSPHATASE_DUAL_dom.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
PRINTSiPR01908. ADSPHPHTASE.
SMARTiSM00195. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDUS19_HUMAN
AccessioniPrimary (citable) accession number: Q8WTR2
Secondary accession number(s): B2RA79, Q547H4, Q8WYN4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 28, 2003
Last sequence update: March 1, 2002
Last modified: November 30, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.