Reviewed,
UniProtKB/Swiss-Prot Q8WTQ7 (GRK7_HUMAN)
Last modified
January 19, 2010.
Version 80.
History...
Clusters with 100%,
90%,
50% identity |
Documents (6) |
Third-party data |
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Names and origin
| Protein names | Recommended name: G protein-coupled receptor kinase 7 EC=2.7.11.16 Alternative name(s): G protein-coupled receptor kinase GRK7 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 553 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Phosphorylates cone opsins thereby initiating their deactivation. |
| Catalytic activity | ATP + [G-protein-coupled receptor] = ADP + [G-protein-coupled receptor] phosphate. |
| Subcellular location | |
| Tissue specificity | Retina. Cones and rod. |
| Sequence similarities | Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. Contains 1 AGC-kinase C-terminal domain. Contains 1 protein kinase domain. Contains 1 RGS domain. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 550 | 550 | G protein-coupled receptor kinase 7 | PRO_0000024332 | |||||
| Propeptide | 551 – 553 | 3 | Removed in mature form By similarity | PRO_0000024333 | |||||
Regions | |||||||||
| Domain | 56 – 176 | 121 | RGS | ||||||
| Domain | 191 – 454 | 264 | Protein kinase | ||||||
| Domain | 455 – 520 | 66 | AGC-kinase C-terminal | ||||||
| Nucleotide binding | 197 – 205 | 9 | ATP By similarity | ||||||
Sites | |||||||||
| Active site | 316 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 220 | 1 | ATP By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 550 | 1 | Cysteine methyl ester Potential | ||||||
| Lipidation | 550 | 1 | S-geranylgeranyl cysteine Potential | ||||||
Natural variations | |||||||||
| Natural variant | 81 | 1 | R → H: dbSNP rs34429284. Ref.3 | VAR_040527 | |||||
| Natural variant | 113 | 1 | C → W: dbSNP rs56070798. Ref.3 | VAR_040528 | |||||
| Natural variant | 115 | 1 | S → C: dbSNP rs34769632. Ref.3 | VAR_040529 | |||||
| Natural variant | 127 | 1 | S → T: dbSNP rs35318124. Ref.3 | VAR_040530 | |||||
| Natural variant | 196 | 1 | V → G: dbSNP rs55707760. Ref.3 | VAR_040531 | |||||
| Natural variant | 196 | 1 | V → M: dbSNP rs56019094. Ref.3 | VAR_040532 | |||||
| Natural variant | 226 | 1 | R → W: dbSNP rs35566288. Ref.3 | VAR_040533 | |||||
| Natural variant | 253 | 1 | S → F in a metastatic melanoma sample; somatic mutation. Ref.3 | VAR_040534 | |||||
| Natural variant | 309 | 1 | E → Q: dbSNP rs55824414. Ref.3 | VAR_040535 | |||||
| Natural variant | 313 | 1 | V → I: dbSNP rs56076641. Ref.3 | VAR_040536 | |||||
| Natural variant | 443 | 1 | E → G: dbSNP rs36009541. Ref.3 | VAR_040537 | |||||
| Natural variant | 460 | 1 | P → T: dbSNP rs33928105. Ref.3 | VAR_040538 | |||||
| Natural variant | 461 | 1 | R → C: dbSNP rs36004830. | VAR_051624 | |||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Characterization of human GRK7 as a potential cone opsin kinase." Chen C.-K., Zhang K., Church-Kopish J., Huang W., Zhang H., Chen Y.-J., Frederick J.M., Baehr W. Mol. Vis. 7:305-313(2001) [PubMed: 11754336] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Retina. |
| [2] | "Species-specific differences in expression of G-protein-coupled receptor kinase (GRK) 7 and GRK1 in mammalian cone photoreceptor cells: implications for cone cell phototransduction." Weiss E.R., Ducceschi M.H., Horner T.J., Li A., Craft C.M., Osawa S. J. Neurosci. 21:9175-9184(2001) [PubMed: 11717351] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Retina. |
| [3] | "Patterns of somatic mutation in human cancer genomes." Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. Stratton M.R.Nature 446:153-158(2007) [PubMed: 17344846] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] HIS-81; TRP-113; CYS-115; THR-127; GLY-196; MET-196; TRP-226; PHE-253; GLN-309; ILE-313; GLY-443 AND THR-460. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AF439409 mRNA. Translation: AAL48216.1. AF282269 mRNA. Translation: AAL33880.1. |
| IPI | IPI00102804. |
| RefSeq | NP_631948.1. |
| UniGene | Hs.680654 |
3D structure databases | |
| SMR | Q8WTQ7. Positions 31-538. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q8WTQ7. |
PTM databases | |
| PhosphoSite | Q8WTQ7. |
Proteomic databases | |
| PRIDE | Q8WTQ7. |
Genome annotation databases | |
| Ensembl | ENST00000264952; ENSP00000264952; ENSG00000114124; Homo sapiens. [Genome view] |
| GeneID | 131890. |
| KEGG | hsa:131890. |
| UCSC | uc003euf.1. human. |
Organism-specific databases | |
| CTD | 131890. |
| GeneCards | GC03P142979. |
| H-InvDB | HIX0030738. |
| HGNC | HGNC:17031. GRK7. |
| MIM | 606987. gene. |
| PharmGKB | PA38433. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | prNOG18375. |
| HOGENOM | HBG716704. |
| HOVERGEN | Q8WTQ7. |
| InParanoid | Q8WTQ7. |
| OMA | WELAEEG. |
| OrthoDB | EOG9X0QBZ. |
| PhylomeDB | Q8WTQ7. |
Enzyme and pathway databases | |
| BRENDA | 2.7.11.14. 247. 2.7.11.16. 247. |
| Pathway_Interaction_DB | cone_pathway. Visual signal transduction: Cones. |
Gene expression databases | |
| ArrayExpress | Q8WTQ7. |
| Bgee | Q8WTQ7. |
| CleanEx | HS_GRK7. |
| Genevestigator | Q8WTQ7. |
| GermOnline | ENSG00000114124. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR000961. AGC-kinase_C. IPR000239. GPCR_kinase. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR000342. Regulat_G_prot_signal. IPR016137. Regulat_G_prot_signal_superfam. IPR017442. Se/Thr_prot_kinase-like_dom. IPR008271. Ser/Thr_prot_kinase_AS. IPR002290. Ser/Thr_prot_kinase_dom. [Graphical view] |
| Pfam | PF00069. Pkinase. 1 hit. PF00615. RGS. 1 hit. [Graphical view] |
| PRINTS | PR00717. GPCRKINASE. |
| SMART | SM00315. RGS. 1 hit. SM00133. S_TK_X. 1 hit. SM00220. S_TKc. 1 hit. [Graphical view] |
| PROSITE | PS51285. AGC_KINASE_CTER. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. PS50132. RGS. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 82983. |
| SOURCE | Search... |
Entry information
| Entry name | GRK7_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q8WTQ7 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 3 Human chromosome 3: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| Human and mouse protein kinases Human and mouse protein kinases: classification and index |
| SIMILARITY comments Index of protein domains and families |

Clusters with


