Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8WTQ6

- Q8WTQ6_HUMAN

UniProt

Q8WTQ6 - Q8WTQ6_HUMAN

Protein
Submitted name:

Nav1.5

Gene

SCN5A

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    GO - Molecular functioni

    1. voltage-gated ion channel activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Ion channel, Voltage-gated channelSAAS annotation

    Keywords - Biological processi

    Ion transport, Transport

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Nav1.5Imported
    Gene namesi
    Name:SCN5AImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    Expressioni

    Gene expression databases

    ArrayExpressiQ8WTQ6.
    BgeeiQ8WTQ6.

    Family & Domainsi

    Keywords - Domaini

    Transmembrane, Transmembrane helixSAAS annotation

    Family and domain databases

    Gene3Di1.20.120.350. 1 hit.
    InterProiIPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    [Graphical view]
    PfamiPF00520. Ion_trans. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q8WTQ6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAQHDPPPWT KYVEYTFTAI YTFESLVKIL ARGFCLHAFT FLRDPWNWLD    50
    FSVIIMAYTT EFVDLGNVSA LRTFRVLRAL KTISVISGLK TIVGALIQSV 100
    KKLADVMVLT VFCLSVFALI GLQLFMGNLR HKCVRNFTAL NGTNGSVEAD 150
    GLVWES 156
    Length:156
    Mass (Da):17,544
    Last modified:March 1, 2002 - v1
    Checksum:iC9EE433E3CB613D5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported
    Non-terminal residuei156 – 1561Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ310890 mRNA. Translation: CAC84533.1.
    AJ310891 mRNA. Translation: CAC84534.1.
    UniGeneiHs.517898.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ310890 mRNA. Translation: CAC84533.1 .
    AJ310891 mRNA. Translation: CAC84534.1 .
    UniGenei Hs.517898.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Gene expression databases

    ArrayExpressi Q8WTQ6.
    Bgeei Q8WTQ6.

    Family and domain databases

    Gene3Di 1.20.120.350. 1 hit.
    InterProi IPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    [Graphical view ]
    Pfami PF00520. Ion_trans. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Upregulation of voltage-gated Na+ channel expression and metastatic potential in human breast cancer: Correlative studies on cell lines and biopsy tissues."
      Diss J.K.J., Fraser S.P., Coombes R.C., Djamgoz M.B.A.
      Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Biopsy sample 1Imported and Biopsy sample 7Imported.
      Tissue: BreastImported.

    Entry informationi

    Entry nameiQ8WTQ6_HUMAN
    AccessioniPrimary (citable) accession number: Q8WTQ6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 1, 2002
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.