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Q8WTQ6

- Q8WTQ6_HUMAN

UniProt

Q8WTQ6 - Q8WTQ6_HUMAN

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Protein
Submitted name:

Nav1.5

Gene

SCN5A

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. voltage-gated ion channel activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Voltage-gated channelSAAS annotation

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Nav1.5Imported
Gene namesi
Name:SCN5AImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiQ8WTQ6.
ExpressionAtlasiQ8WTQ6. baseline and differential.

Interactioni

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotation

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
[Graphical view]
PfamiPF00520. Ion_trans. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q8WTQ6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAQHDPPPWT KYVEYTFTAI YTFESLVKIL ARGFCLHAFT FLRDPWNWLD
60 70 80 90 100
FSVIIMAYTT EFVDLGNVSA LRTFRVLRAL KTISVISGLK TIVGALIQSV
110 120 130 140 150
KKLADVMVLT VFCLSVFALI GLQLFMGNLR HKCVRNFTAL NGTNGSVEAD

GLVWES
Length:156
Mass (Da):17,544
Last modified:March 1, 2002 - v1
Checksum:iC9EE433E3CB613D5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei156 – 1561Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ310890 mRNA. Translation: CAC84533.1.
AJ310891 mRNA. Translation: CAC84534.1.
UniGeneiHs.517898.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ310890 mRNA. Translation: CAC84533.1 .
AJ310891 mRNA. Translation: CAC84534.1 .
UniGenei Hs.517898.

3D structure databases

ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi Q8WTQ6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Gene expression databases

Bgeei Q8WTQ6.
ExpressionAtlasi Q8WTQ6. baseline and differential.

Family and domain databases

Gene3Di 1.20.120.350. 1 hit.
InterProi IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
[Graphical view ]
Pfami PF00520. Ion_trans. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Upregulation of voltage-gated Na+ channel expression and metastatic potential in human breast cancer: Correlative studies on cell lines and biopsy tissues."
    Diss J.K.J., Fraser S.P., Coombes R.C., Djamgoz M.B.A.
    Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Biopsy sample 1Imported and Biopsy sample 7Imported.
    Tissue: BreastImported.

Entry informationi

Entry nameiQ8WTQ6_HUMAN
AccessioniPrimary (citable) accession number: Q8WTQ6
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: November 26, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.