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Q8WTQ6

- Q8WTQ6_HUMAN

UniProt

Q8WTQ6 - Q8WTQ6_HUMAN

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Protein
Submitted name: Nav1.5
Gene
SCN5A
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. ion channel activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Voltage-gated channelSAAS annotations

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Nav1.5Imported
Gene namesi
Name:SCN5AImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

ArrayExpressiQ8WTQ6.
BgeeiQ8WTQ6.

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotations

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
[Graphical view]
PfamiPF00520. Ion_trans. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q8WTQ6-1 [UniParc]FASTAAdd to Basket

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MAQHDPPPWT KYVEYTFTAI YTFESLVKIL ARGFCLHAFT FLRDPWNWLD    50
FSVIIMAYTT EFVDLGNVSA LRTFRVLRAL KTISVISGLK TIVGALIQSV 100
KKLADVMVLT VFCLSVFALI GLQLFMGNLR HKCVRNFTAL NGTNGSVEAD 150
GLVWES 156
Length:156
Mass (Da):17,544
Last modified:March 1, 2002 - v1
Checksum:iC9EE433E3CB613D5
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei156 – 1561Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ310890 mRNA. Translation: CAC84533.1.
AJ310891 mRNA. Translation: CAC84534.1.
UniGeneiHs.517898.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ310890 mRNA. Translation: CAC84533.1 .
AJ310891 mRNA. Translation: CAC84534.1 .
UniGenei Hs.517898.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Gene expression databases

ArrayExpressi Q8WTQ6.
Bgeei Q8WTQ6.

Family and domain databases

Gene3Di 1.20.120.350. 1 hit.
InterProi IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
[Graphical view ]
Pfami PF00520. Ion_trans. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Upregulation of voltage-gated Na+ channel expression and metastatic potential in human breast cancer: Correlative studies on cell lines and biopsy tissues."
    Diss J.K.J., Fraser S.P., Coombes R.C., Djamgoz M.B.A.
    Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Biopsy sample 1Imported and Biopsy sample 7Imported.
    Tissue: BreastImported.

Entry informationi

Entry nameiQ8WTQ6_HUMAN
AccessioniPrimary (citable) accession number: Q8WTQ6
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: July 9, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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