ID   XAGE3_HUMAN             Reviewed;         111 AA.
AC   Q8WTP9; Q5JS82; Q8WYS9;
DT   17-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   27-MAR-2024, entry version 138.
DE   RecName: Full=X antigen family member 3;
DE            Short=XAGE-3;
DE   AltName: Full=Cancer/testis antigen 12.3;
DE            Short=CT12.3;
DE   AltName: Full=G antigen family D member 4;
DE   AltName: Full=Placenta-specific gene 6 protein;
GN   Name=XAGE3; Synonyms=GAGED4, PLAC6; ORFNames=PP9012;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11992404; DOI=10.1002/ijc.10371;
RA   Zendman A.J.W., van Kraats A.A., Weidle U.H., Ruiter D.J.,
RA   van Muijen G.N.P.;
RT   "The XAGE family of cancer/testis-associated genes: alignment and
RT   expression profile in normal tissues, melanoma lesions and Ewing's
RT   sarcoma.";
RL   Int. J. Cancer 99:361-369(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15498874; DOI=10.1073/pnas.0404089101;
RA   Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X.,
RA   Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.,
RA   Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.;
RT   "Large-scale cDNA transfection screening for genes related to cancer
RT   development and progression.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15772651; DOI=10.1038/nature03440;
RA   Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
RA   Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
RA   Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
RA   Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
RA   Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
RA   Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
RA   Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
RA   Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
RA   Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
RA   Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
RA   Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
RA   Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
RA   Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
RA   Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
RA   Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
RA   Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
RA   Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
RA   Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
RA   Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
RA   Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
RA   Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
RA   Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
RA   Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
RA   Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
RA   Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
RA   Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
RA   Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
RA   Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
RA   Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
RA   Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
RA   McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
RA   Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
RA   Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
RA   Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
RA   Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
RA   Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
RA   Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
RA   Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
RA   Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
RA   Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
RA   d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
RA   Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
RA   Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
RA   Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
RA   Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
RA   Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
RA   Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
RA   Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
RA   Rogers J., Bentley D.R.;
RT   "The DNA sequence of the human X chromosome.";
RL   Nature 434:325-337(2005).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Placenta;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- INTERACTION:
CC       Q8WTP9; P13569: CFTR; NbExp=4; IntAct=EBI-6448284, EBI-349854;
CC       Q8WTP9; Q53SE7: FLJ13057; NbExp=3; IntAct=EBI-6448284, EBI-10172181;
CC       Q8WTP9; Q96IK5: GMCL1; NbExp=6; IntAct=EBI-6448284, EBI-2548508;
CC       Q8WTP9; P42858: HTT; NbExp=3; IntAct=EBI-6448284, EBI-466029;
CC       Q8WTP9; Q5TA81: LCE2C; NbExp=3; IntAct=EBI-6448284, EBI-11973993;
CC   -!- SIMILARITY: Belongs to the GAGE family. {ECO:0000305}.
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DR   EMBL; AJ318881; CAC83008.1; -; mRNA.
DR   EMBL; AJ318893; CAC83014.1; -; Genomic_DNA.
DR   EMBL; AF318372; AAL55879.1; -; mRNA.
DR   EMBL; AL445236; CAI41615.1; -; Genomic_DNA.
DR   EMBL; BC062680; AAH62680.1; -; mRNA.
DR   CCDS; CCDS14347.1; -.
DR   RefSeq; NP_570132.1; NM_130776.1.
DR   RefSeq; NP_573440.1; NM_133179.2.
DR   RefSeq; XP_011529070.1; XM_011530768.2.
DR   RefSeq; XP_011529071.1; XM_011530769.2.
DR   RefSeq; XP_011529072.1; XM_011530770.2.
DR   AlphaFoldDB; Q8WTP9; -.
DR   BioGRID; 128072; 21.
DR   IntAct; Q8WTP9; 19.
DR   MINT; Q8WTP9; -.
DR   STRING; 9606.ENSP00000303061; -.
DR   iPTMnet; Q8WTP9; -.
DR   PhosphoSitePlus; Q8WTP9; -.
DR   BioMuta; XAGE3; -.
DR   DMDM; 27805666; -.
DR   MassIVE; Q8WTP9; -.
DR   MaxQB; Q8WTP9; -.
DR   PaxDb; 9606-ENSP00000303061; -.
DR   PeptideAtlas; Q8WTP9; -.
DR   Antibodypedia; 71027; 4 antibodies from 4 providers.
DR   DNASU; 170626; -.
DR   Ensembl; ENST00000346279.4; ENSP00000303061.3; ENSG00000171402.15.
DR   Ensembl; ENST00000375491.7; ENSP00000364640.3; ENSG00000171402.15.
DR   GeneID; 170626; -.
DR   KEGG; hsa:170626; -.
DR   MANE-Select; ENST00000346279.4; ENSP00000303061.3; NM_133179.3; NP_573440.1.
DR   UCSC; uc004dre.4; human.
DR   AGR; HGNC:14618; -.
DR   CTD; 170626; -.
DR   DisGeNET; 170626; -.
DR   GeneCards; XAGE3; -.
DR   HGNC; HGNC:14618; XAGE3.
DR   HPA; ENSG00000171402; Tissue enriched (placenta).
DR   MIM; 300740; gene.
DR   neXtProt; NX_Q8WTP9; -.
DR   OpenTargets; ENSG00000171402; -.
DR   PharmGKB; PA33376; -.
DR   VEuPathDB; HostDB:ENSG00000171402; -.
DR   eggNOG; ENOG502TF3A; Eukaryota.
DR   GeneTree; ENSGT00940000153097; -.
DR   HOGENOM; CLU_150116_2_1_1; -.
DR   InParanoid; Q8WTP9; -.
DR   OMA; IFANHTC; -.
DR   OrthoDB; 4705021at2759; -.
DR   PhylomeDB; Q8WTP9; -.
DR   TreeFam; TF340669; -.
DR   PathwayCommons; Q8WTP9; -.
DR   SignaLink; Q8WTP9; -.
DR   BioGRID-ORCS; 170626; 105 hits in 721 CRISPR screens.
DR   GenomeRNAi; 170626; -.
DR   Pharos; Q8WTP9; Tdark.
DR   PRO; PR:Q8WTP9; -.
DR   Proteomes; UP000005640; Chromosome X.
DR   RNAct; Q8WTP9; Protein.
DR   Bgee; ENSG00000171402; Expressed in placenta and 50 other cell types or tissues.
DR   InterPro; IPR031320; GAGE.
DR   InterPro; IPR008625; GAGE_fam.
DR   PANTHER; PTHR14047; P ANTIGEN FAMILY MEMBER 5-RELATED; 1.
DR   PANTHER; PTHR14047:SF4; X ANTIGEN FAMILY MEMBER 3; 1.
DR   Pfam; PF05831; GAGE; 1.
DR   SMART; SM01379; GAGE; 1.
DR   Genevisible; Q8WTP9; HS.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..111
FT                   /note="X antigen family member 3"
FT                   /id="PRO_0000148351"
FT   REGION          1..111
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        37..59
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        68..82
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        11
FT                   /note="P -> H (in Ref. 2; AAL55879)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   111 AA;  12302 MW;  F4A3261E6F7ACF5B CRC64;
     MIWRGRSTYR PRPRRSVPPP ELIGPMLEPG DEEPQQEEPP TESRDPAPGQ EREEDQGAAE
     TQVPDLEADL QELSQSKTGG ECGNGPDDQG KILPKSEQFK MPEGGDRQPQ V
//