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Protein

X antigen family member 3

Gene

XAGE3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
X antigen family member 3
Short name:
XAGE-3
Alternative name(s):
Cancer/testis antigen 12.3
Short name:
CT12.3
G antigen family D member 4
Placenta-specific gene 6 protein
Gene namesi
Name:XAGE3
Synonyms:GAGED4, PLAC6
ORF Names:PP9012
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:14618. XAGE3.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33376.

Polymorphism and mutation databases

BioMutaiXAGE3.
DMDMi27805666.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 111111X antigen family member 3PRO_0000148351Add
BLAST

Proteomic databases

PRIDEiQ8WTP9.

Expressioni

Gene expression databases

BgeeiQ8WTP9.
CleanExiHS_XAGE3.
GenevisibleiQ8WTP9. HS.

Organism-specific databases

HPAiHPA052507.
HPA059045.
HPA060900.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
FLJ13057Q53SE73EBI-6448284,EBI-10172181
HTTP428583EBI-6448284,EBI-466029

Protein-protein interaction databases

BioGridi128072. 2 interactions.
IntActiQ8WTP9. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ8WTP9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GAGE family.Curated

Phylogenomic databases

eggNOGiNOG78205.
GeneTreeiENSGT00760000119430.
HOGENOMiHOG000237345.
HOVERGENiHBG056227.
InParanoidiQ8WTP9.
OMAiCGNGPDD.
OrthoDBiEOG7KWSM8.
PhylomeDBiQ8WTP9.
TreeFamiTF340669.

Family and domain databases

InterProiIPR008625. GAGE.
[Graphical view]
PfamiPF05831. GAGE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WTP9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIWRGRSTYR PRPRRSVPPP ELIGPMLEPG DEEPQQEEPP TESRDPAPGQ
60 70 80 90 100
EREEDQGAAE TQVPDLEADL QELSQSKTGG ECGNGPDDQG KILPKSEQFK
110
MPEGGDRQPQ V
Length:111
Mass (Da):12,302
Last modified:March 1, 2002 - v1
Checksum:iF4A3261E6F7ACF5B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti11 – 111P → H in AAL55879 (PubMed:15498874).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ318881 mRNA. Translation: CAC83008.1.
AJ318893 Genomic DNA. Translation: CAC83014.1.
AF318372 mRNA. Translation: AAL55879.1.
AL445236 Genomic DNA. Translation: CAI41615.1.
BC062680 mRNA. Translation: AAH62680.1.
CCDSiCCDS14347.1.
RefSeqiNP_570132.1. NM_130776.1.
NP_573440.1. NM_133179.2.
UniGeneiHs.43879.

Genome annotation databases

EnsembliENST00000346279; ENSP00000303061; ENSG00000171402.
ENST00000375491; ENSP00000364640; ENSG00000171402.
GeneIDi170626.
KEGGihsa:170626.
UCSCiuc004dre.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ318881 mRNA. Translation: CAC83008.1.
AJ318893 Genomic DNA. Translation: CAC83014.1.
AF318372 mRNA. Translation: AAL55879.1.
AL445236 Genomic DNA. Translation: CAI41615.1.
BC062680 mRNA. Translation: AAH62680.1.
CCDSiCCDS14347.1.
RefSeqiNP_570132.1. NM_130776.1.
NP_573440.1. NM_133179.2.
UniGeneiHs.43879.

3D structure databases

ProteinModelPortaliQ8WTP9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128072. 2 interactions.
IntActiQ8WTP9. 3 interactions.

Polymorphism and mutation databases

BioMutaiXAGE3.
DMDMi27805666.

Proteomic databases

PRIDEiQ8WTP9.

Protocols and materials databases

DNASUi170626.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000346279; ENSP00000303061; ENSG00000171402.
ENST00000375491; ENSP00000364640; ENSG00000171402.
GeneIDi170626.
KEGGihsa:170626.
UCSCiuc004dre.3. human.

Organism-specific databases

CTDi170626.
GeneCardsiGC0XM052908.
HGNCiHGNC:14618. XAGE3.
HPAiHPA052507.
HPA059045.
HPA060900.
MIMi300740. gene.
neXtProtiNX_Q8WTP9.
PharmGKBiPA33376.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG78205.
GeneTreeiENSGT00760000119430.
HOGENOMiHOG000237345.
HOVERGENiHBG056227.
InParanoidiQ8WTP9.
OMAiCGNGPDD.
OrthoDBiEOG7KWSM8.
PhylomeDBiQ8WTP9.
TreeFamiTF340669.

Miscellaneous databases

GenomeRNAii170626.
NextBioi89070.
PROiQ8WTP9.
SOURCEiSearch...

Gene expression databases

BgeeiQ8WTP9.
CleanExiHS_XAGE3.
GenevisibleiQ8WTP9. HS.

Family and domain databases

InterProiIPR008625. GAGE.
[Graphical view]
PfamiPF05831. GAGE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The XAGE family of cancer/testis-associated genes: alignment and expression profile in normal tissues, melanoma lesions and Ewing's sarcoma."
    Zendman A.J.W., van Kraats A.A., Weidle U.H., Ruiter D.J., van Muijen G.N.P.
    Int. J. Cancer 99:361-369(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
    Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
    , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
    Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.

Entry informationi

Entry nameiXAGE3_HUMAN
AccessioniPrimary (citable) accession number: Q8WTP9
Secondary accession number(s): Q5JS82, Q8WYS9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: March 1, 2002
Last modified: June 24, 2015
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.