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Q8WTP9

- XAGE3_HUMAN

UniProt

Q8WTP9 - XAGE3_HUMAN

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Protein

X antigen family member 3

Gene

XAGE3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
X antigen family member 3
Short name:
XAGE-3
Alternative name(s):
Cancer/testis antigen 12.3
Short name:
CT12.3
G antigen family D member 4
Placenta-specific gene 6 protein
Gene namesi
Name:XAGE3
Synonyms:GAGED4, PLAC6
ORF Names:PP9012
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:14618. XAGE3.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33376.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 111111X antigen family member 3PRO_0000148351Add
BLAST

Proteomic databases

PRIDEiQ8WTP9.

Expressioni

Gene expression databases

BgeeiQ8WTP9.
CleanExiHS_XAGE3.
GenevestigatoriQ8WTP9.

Organism-specific databases

HPAiHPA052507.
HPA059045.
HPA060900.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
HTTP428583EBI-6448284,EBI-466029

Protein-protein interaction databases

BioGridi128072. 1 interaction.
IntActiQ8WTP9. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ8WTP9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GAGE family.Curated

Phylogenomic databases

eggNOGiNOG78205.
GeneTreeiENSGT00760000119430.
HOGENOMiHOG000237345.
HOVERGENiHBG056227.
InParanoidiQ8WTP9.
OMAiCGNGPDD.
OrthoDBiEOG7KWSM8.
PhylomeDBiQ8WTP9.
TreeFamiTF340669.

Family and domain databases

InterProiIPR008625. GAGE.
[Graphical view]
PfamiPF05831. GAGE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WTP9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIWRGRSTYR PRPRRSVPPP ELIGPMLEPG DEEPQQEEPP TESRDPAPGQ
60 70 80 90 100
EREEDQGAAE TQVPDLEADL QELSQSKTGG ECGNGPDDQG KILPKSEQFK
110
MPEGGDRQPQ V
Length:111
Mass (Da):12,302
Last modified:March 1, 2002 - v1
Checksum:iF4A3261E6F7ACF5B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti11 – 111P → H in AAL55879. (PubMed:15498874)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ318881 mRNA. Translation: CAC83008.1.
AJ318893 Genomic DNA. Translation: CAC83014.1.
AF318372 mRNA. Translation: AAL55879.1.
AL445236 Genomic DNA. Translation: CAI41615.1.
BC062680 mRNA. Translation: AAH62680.1.
CCDSiCCDS14347.1.
RefSeqiNP_570132.1. NM_130776.1.
NP_573440.1. NM_133179.2.
UniGeneiHs.43879.

Genome annotation databases

EnsembliENST00000346279; ENSP00000303061; ENSG00000171402.
ENST00000375491; ENSP00000364640; ENSG00000171402.
GeneIDi170626.
KEGGihsa:170626.
UCSCiuc004dre.3. human.

Polymorphism databases

DMDMi27805666.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ318881 mRNA. Translation: CAC83008.1 .
AJ318893 Genomic DNA. Translation: CAC83014.1 .
AF318372 mRNA. Translation: AAL55879.1 .
AL445236 Genomic DNA. Translation: CAI41615.1 .
BC062680 mRNA. Translation: AAH62680.1 .
CCDSi CCDS14347.1.
RefSeqi NP_570132.1. NM_130776.1.
NP_573440.1. NM_133179.2.
UniGenei Hs.43879.

3D structure databases

ProteinModelPortali Q8WTP9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 128072. 1 interaction.
IntActi Q8WTP9. 1 interaction.

Polymorphism databases

DMDMi 27805666.

Proteomic databases

PRIDEi Q8WTP9.

Protocols and materials databases

DNASUi 170626.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000346279 ; ENSP00000303061 ; ENSG00000171402 .
ENST00000375491 ; ENSP00000364640 ; ENSG00000171402 .
GeneIDi 170626.
KEGGi hsa:170626.
UCSCi uc004dre.3. human.

Organism-specific databases

CTDi 170626.
GeneCardsi GC0XM052908.
HGNCi HGNC:14618. XAGE3.
HPAi HPA052507.
HPA059045.
HPA060900.
MIMi 300740. gene.
neXtProti NX_Q8WTP9.
PharmGKBi PA33376.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG78205.
GeneTreei ENSGT00760000119430.
HOGENOMi HOG000237345.
HOVERGENi HBG056227.
InParanoidi Q8WTP9.
OMAi CGNGPDD.
OrthoDBi EOG7KWSM8.
PhylomeDBi Q8WTP9.
TreeFami TF340669.

Miscellaneous databases

GenomeRNAii 170626.
NextBioi 89070.
PROi Q8WTP9.
SOURCEi Search...

Gene expression databases

Bgeei Q8WTP9.
CleanExi HS_XAGE3.
Genevestigatori Q8WTP9.

Family and domain databases

InterProi IPR008625. GAGE.
[Graphical view ]
Pfami PF05831. GAGE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The XAGE family of cancer/testis-associated genes: alignment and expression profile in normal tissues, melanoma lesions and Ewing's sarcoma."
    Zendman A.J.W., van Kraats A.A., Weidle U.H., Ruiter D.J., van Muijen G.N.P.
    Int. J. Cancer 99:361-369(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
    Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
    , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
    Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.

Entry informationi

Entry nameiXAGE3_HUMAN
AccessioniPrimary (citable) accession number: Q8WTP9
Secondary accession number(s): Q5JS82, Q8WYS9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 17, 2003
Last sequence update: March 1, 2002
Last modified: October 29, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3