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Q8WTP9

- XAGE3_HUMAN

UniProt

Q8WTP9 - XAGE3_HUMAN

Protein

X antigen family member 3

Gene

XAGE3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Molecular functioni

    1. protein binding Source: IntAct

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    X antigen family member 3
    Short name:
    XAGE-3
    Alternative name(s):
    Cancer/testis antigen 12.3
    Short name:
    CT12.3
    G antigen family D member 4
    Placenta-specific gene 6 protein
    Gene namesi
    Name:XAGE3
    Synonyms:GAGED4, PLAC6
    ORF Names:PP9012
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:14618. XAGE3.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33376.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 111111X antigen family member 3PRO_0000148351Add
    BLAST

    Proteomic databases

    PRIDEiQ8WTP9.

    Expressioni

    Gene expression databases

    BgeeiQ8WTP9.
    CleanExiHS_XAGE3.
    GenevestigatoriQ8WTP9.

    Organism-specific databases

    HPAiHPA052507.
    HPA059045.
    HPA060900.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    HTTP428583EBI-6448284,EBI-466029

    Protein-protein interaction databases

    BioGridi128072. 1 interaction.
    IntActiQ8WTP9. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8WTP9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GAGE family.Curated

    Phylogenomic databases

    eggNOGiNOG78205.
    HOGENOMiHOG000237345.
    HOVERGENiHBG056227.
    InParanoidiQ8WTP9.
    OMAiCGNGPDD.
    OrthoDBiEOG7KWSM8.
    PhylomeDBiQ8WTP9.
    TreeFamiTF340669.

    Family and domain databases

    InterProiIPR008625. GAGE.
    [Graphical view]
    PfamiPF05831. GAGE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8WTP9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIWRGRSTYR PRPRRSVPPP ELIGPMLEPG DEEPQQEEPP TESRDPAPGQ    50
    EREEDQGAAE TQVPDLEADL QELSQSKTGG ECGNGPDDQG KILPKSEQFK 100
    MPEGGDRQPQ V 111
    Length:111
    Mass (Da):12,302
    Last modified:March 1, 2002 - v1
    Checksum:iF4A3261E6F7ACF5B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti11 – 111P → H in AAL55879. (PubMed:15498874)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ318881 mRNA. Translation: CAC83008.1.
    AJ318893 Genomic DNA. Translation: CAC83014.1.
    AF318372 mRNA. Translation: AAL55879.1.
    AL445236 Genomic DNA. Translation: CAI41615.1.
    BC062680 mRNA. Translation: AAH62680.1.
    CCDSiCCDS14347.1.
    RefSeqiNP_570132.1. NM_130776.1.
    NP_573440.1. NM_133179.2.
    UniGeneiHs.43879.

    Genome annotation databases

    EnsembliENST00000346279; ENSP00000303061; ENSG00000171402.
    ENST00000375491; ENSP00000364640; ENSG00000171402.
    GeneIDi170626.
    KEGGihsa:170626.
    UCSCiuc004dre.3. human.

    Polymorphism databases

    DMDMi27805666.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ318881 mRNA. Translation: CAC83008.1 .
    AJ318893 Genomic DNA. Translation: CAC83014.1 .
    AF318372 mRNA. Translation: AAL55879.1 .
    AL445236 Genomic DNA. Translation: CAI41615.1 .
    BC062680 mRNA. Translation: AAH62680.1 .
    CCDSi CCDS14347.1.
    RefSeqi NP_570132.1. NM_130776.1.
    NP_573440.1. NM_133179.2.
    UniGenei Hs.43879.

    3D structure databases

    ProteinModelPortali Q8WTP9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 128072. 1 interaction.
    IntActi Q8WTP9. 1 interaction.

    Polymorphism databases

    DMDMi 27805666.

    Proteomic databases

    PRIDEi Q8WTP9.

    Protocols and materials databases

    DNASUi 170626.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000346279 ; ENSP00000303061 ; ENSG00000171402 .
    ENST00000375491 ; ENSP00000364640 ; ENSG00000171402 .
    GeneIDi 170626.
    KEGGi hsa:170626.
    UCSCi uc004dre.3. human.

    Organism-specific databases

    CTDi 170626.
    GeneCardsi GC0XM052908.
    HGNCi HGNC:14618. XAGE3.
    HPAi HPA052507.
    HPA059045.
    HPA060900.
    MIMi 300740. gene.
    neXtProti NX_Q8WTP9.
    PharmGKBi PA33376.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG78205.
    HOGENOMi HOG000237345.
    HOVERGENi HBG056227.
    InParanoidi Q8WTP9.
    OMAi CGNGPDD.
    OrthoDBi EOG7KWSM8.
    PhylomeDBi Q8WTP9.
    TreeFami TF340669.

    Miscellaneous databases

    GenomeRNAii 170626.
    NextBioi 89070.
    PROi Q8WTP9.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8WTP9.
    CleanExi HS_XAGE3.
    Genevestigatori Q8WTP9.

    Family and domain databases

    InterProi IPR008625. GAGE.
    [Graphical view ]
    Pfami PF05831. GAGE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The XAGE family of cancer/testis-associated genes: alignment and expression profile in normal tissues, melanoma lesions and Ewing's sarcoma."
      Zendman A.J.W., van Kraats A.A., Weidle U.H., Ruiter D.J., van Muijen G.N.P.
      Int. J. Cancer 99:361-369(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Large-scale cDNA transfection screening for genes related to cancer development and progression."
      Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.
      , Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.
      Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.

    Entry informationi

    Entry nameiXAGE3_HUMAN
    AccessioniPrimary (citable) accession number: Q8WTP9
    Secondary accession number(s): Q5JS82, Q8WYS9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 17, 2003
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3