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Q8WTE7

- OR1_ANOGA

UniProt

Q8WTE7 - OR1_ANOGA

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Protein

Odorant receptor Or1

Gene
OR1, AGAP009640
Organism
Anopheles gambiae (African malaria mosquito)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Odorant receptor which plays a critical role in the anthropophilic host-seeking behavior; establishes the host preference to transmit malaria. May participate in the phenomenon of decreased host-seeking behavior in disease vector mosquitoes after blood feeding.2 Publications

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. odorant binding Source: UniProtKB
  3. olfactory receptor activity Source: UniProtKB

GO - Biological processi

  1. detection of chemical stimulus involved in sensory perception of smell Source: GOC
  2. olfactory behavior Source: UniProtKB
  3. sensory perception of smell Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Names & Taxonomyi

Protein namesi
Recommended name:
Odorant receptor Or1
Alternative name(s):
AgOr1
Gene namesi
Name:OR1
ORF Names:AGAP009640
OrganismiAnopheles gambiae (African malaria mosquito)
Taxonomic identifieri7165 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeAnophelinaeAnopheles
ProteomesiUP000007062: Chromosome 3R

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 22Cytoplasmic Reviewed prediction
Transmembranei3 – 2321Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini24 – 4522Extracellular Reviewed predictionAdd
BLAST
Transmembranei46 – 6621Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini67 – 737Cytoplasmic Reviewed prediction
Transmembranei74 – 9421Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini95 – 13339Extracellular Reviewed predictionAdd
BLAST
Transmembranei134 – 15421Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini155 – 17824Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei179 – 19921Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini200 – 28485Extracellular Reviewed predictionAdd
BLAST
Transmembranei285 – 30521Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini306 – 31712Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei318 – 33821Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini339 – 41779Extracellular Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 417417Odorant receptor Or1PRO_0000174286Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi112 – 1121N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Expressioni

Tissue specificityi

Female-specific antennae and maxillary palp expression.2 Publications

Inductioni

Strong response to the odorant 4-methylphenol, a component of human sweat, when expressed in odorant receptor deficient Drosophila. In vivo, decreased expression in antennae after a blood meal.2 Publications

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG327334.
HOGENOMiHOG000044066.
InParanoidiQ6VPM5.
KOiK08471.
OMAiYNIARIQ.
OrthoDBiEOG73Z2T8.
PhylomeDBiQ8WTE7.

Family and domain databases

InterProiIPR004117. 7tm6_olfct_rcpt.
[Graphical view]
PANTHERiPTHR21137. PTHR21137. 1 hit.
PfamiPF02949. 7tm_6. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WTE7-1 [UniParc]FASTAAdd to Basket

« Hide

MKLNKLNPRW DAYDRRDSFW LQLLCLKYLG LWPPEDTDQA TRNRYIAYGW    50
ALRIMFLHLY ALTQALYFKD VKDINDIANA LFVLMTQVTL IYKLEKFNYN 100
IARIQACLRK LNCTLYHPKQ REEFSPVLQS MSGVFWLMIF LMFVAIFTII 150
MWVMSPAFDN ERRLPVPAWF PVDYHHSDIV YGVLFLYQTI GIVMSATYNF 200
STDTMFSGLM LHINGQIVRL GSMVKKLGHD VPPERQLVAT DAEWKEMRKR 250
IDHHSKVYGT MYAKVTECVL FHKDILSFGD EVQDIFQGSI FAQVCASVII 300
ICMTLLQATG DDVTMADLLG CGFYLLVMTS QVFIFCYVGN EISYTTDKFT 350
EFVGFSNYFK FDKRTSQAMI FFLQMTLKDV HIKVGSVLKV TLNLHTFLQI 400
MKLSYSYLAV LQSMESE 417
Length:417
Mass (Da):48,520
Last modified:March 1, 2002 - v1
Checksum:iF60D7D7BD93D37F2
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti55 – 551M → V in AAR01130. 1 Publication
Sequence conflicti55 – 551M → V in AAR01131. 1 Publication
Sequence conflicti55 – 551M → V in AAR01132. 1 Publication
Sequence conflicti129 – 1291Q → R in AAR01130. 1 Publication
Sequence conflicti129 – 1291Q → R in AAR01131. 1 Publication
Sequence conflicti129 – 1291Q → R in AAR01132. 1 Publication
Sequence conflicti176 – 1761H → R in AAR01130. 1 Publication
Sequence conflicti176 – 1761H → R in AAR01131. 1 Publication
Sequence conflicti176 – 1761H → R in AAR01132. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF364130 Genomic DNA. Translation: AAL35506.1.
AAAB01008980 Genomic DNA. Translation: EAA13838.1.
AY334005 Genomic DNA. Translation: AAR01130.1.
AY334006 Genomic DNA. Translation: AAR01131.1.
AY334007 Genomic DNA. Translation: AAR01132.1.
RefSeqiXP_318674.1. XM_318674.1.

Genome annotation databases

EnsemblMetazoaiAGAP009640-RA; AGAP009640-PA; AGAP009640.
GeneIDi1279017.
KEGGiaga:AgaP_AGAP009640.
VectorBaseiAGAP009639. Anopheles gambiae.

Cross-referencesi

Web resourcesi

Protein Spotlight

What mosquitoes sniff - Issue 44 of March 2004

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF364130 Genomic DNA. Translation: AAL35506.1 .
AAAB01008980 Genomic DNA. Translation: EAA13838.1 .
AY334005 Genomic DNA. Translation: AAR01130.1 .
AY334006 Genomic DNA. Translation: AAR01131.1 .
AY334007 Genomic DNA. Translation: AAR01132.1 .
RefSeqi XP_318674.1. XM_318674.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai AGAP009640-RA ; AGAP009640-PA ; AGAP009640 .
GeneIDi 1279017.
KEGGi aga:AgaP_AGAP009640.
VectorBasei AGAP009639. Anopheles gambiae.

Organism-specific databases

CTDi 1279017.

Phylogenomic databases

eggNOGi NOG327334.
HOGENOMi HOG000044066.
InParanoidi Q6VPM5.
KOi K08471.
OMAi YNIARIQ.
OrthoDBi EOG73Z2T8.
PhylomeDBi Q8WTE7.

Family and domain databases

InterProi IPR004117. 7tm6_olfct_rcpt.
[Graphical view ]
PANTHERi PTHR21137. PTHR21137. 1 hit.
Pfami PF02949. 7tm_6. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Candidate odorant receptors from the malaria vector mosquito Anopheles gambiae and evidence of down-regulation in response to blood feeding."
    Fox A.N., Pitts R.J., Robertson H.M., Carlson J.R., Zwiebel L.J.
    Proc. Natl. Acad. Sci. U.S.A. 98:14693-14697(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, INDUCTION, TISSUE SPECIFICITY.
    Strain: G3.
  2. "The genome sequence of the malaria mosquito Anopheles gambiae."
    Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R., Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R., Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z., Kraft C.L., Abril J.F.
    , Anthouard V., Arensburger P., Atkinson P.W., Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C., Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K., Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V., Dana A., Delcher A., Dew I., Evans C.A., Flanigan M., Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R., Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J., Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I., Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A., McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D., O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H., Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J., Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B., Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M., Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I., Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J., Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M., Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C., Collins F.H., Hoffman S.L.
    Science 298:129-149(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PEST.
  3. "Intraspecific nucleotide variation in Anopheles gambiae: new insights into the biology of malaria vectors."
    Morlais I., Poncon N., Simard F., Cohuet A., Fontenille D.
    Am. J. Trop. Med. Hyg. 71:795-802(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-236.
    Strain: 4aRR, L3-5 and Yaounde.
  4. "Olfaction: mosquito receptor for human-sweat odorant."
    Hallem E.A., Fox A.N., Zwiebel L.J., Carlson J.R.
    Nature 427:212-213(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION.
  5. Cited for: IDENTIFICATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiOR1_ANOGA
AccessioniPrimary (citable) accession number: Q8WTE7
Secondary accession number(s): Q6VPM5, Q7Q1T3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: March 1, 2002
Last modified: September 3, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3