Q8WTE7 (OR1_ANOGA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Odorant receptor Or1

Alternative name(s):
AgOr1

Gene names

Name:	OR1
ORF Names:	AGAP009640

Organism

Anopheles gambiae (African malaria mosquito) [Reference proteome]

Taxonomic identifier

7165 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Diptera › Nematocera › Culicimorpha › Culicoidea › Culicidae › Anophelinae › Anopheles › Cellia › Pyretophorus › gambiae species complex

Protein attributes

Sequence length	417 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Plays a critical role in the anthropophilic host-seeking behavior; establishes the host preference to transmit malaria. May participate in the phenomenon of decreased host-seeking behavior in disease vector mosquitoes after blood feeding. Ref.1 Ref.4
Subcellular location	Cell membrane; Multi-pass membrane protein Potential.
Tissue specificity	Female-specific antennae and maxillary palp expression. Ref.1 Ref.5
Induction	Strong response to the odorant 4-methylphenol, a component of human sweat, when expressed in odorant receptor deficient Drosophila. In vivo, decreased expression in antennae after a blood meal. Ref.1 Ref.4
Sequence similarities	Belongs to the heteromeric odorant receptor channel (TC 1.A.69) family. [View classification]

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	olfactory behavior Inferred from direct assay Ref.4. Source: UniProtKB
Cellular_component	integral to membrane Non-traceable author statement Ref.4. Source: UniProtKB plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW odorant binding Inferred from direct assay Ref.4. Source: UniProtKB olfactory receptor activity Inferred from direct assay Ref.4. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 417	417	Odorant receptor Or1		PRO_0000174286
Regions
	Topological domain	1 – 2	2	Cytoplasmic Potential
	Transmembrane	3 – 23	21	Helical; Name=1; Potential
	Topological domain	24 – 45	22	Extracellular Potential
	Transmembrane	46 – 66	21	Helical; Name=2; Potential
	Topological domain	67 – 73	7	Cytoplasmic Potential
	Transmembrane	74 – 94	21	Helical; Name=3; Potential
	Topological domain	95 – 133	39	Extracellular Potential
	Transmembrane	134 – 154	21	Helical; Name=4; Potential
	Topological domain	155 – 178	24	Cytoplasmic Potential
	Transmembrane	179 – 199	21	Helical; Name=5; Potential
	Topological domain	200 – 284	85	Extracellular Potential
	Transmembrane	285 – 305	21	Helical; Name=6; Potential
	Topological domain	306 – 317	12	Cytoplasmic Potential
	Transmembrane	318 – 338	21	Helical; Name=7; Potential
	Topological domain	339 – 417	79	Extracellular Potential
Amino acid modifications
	Glycosylation	112	1	N-linked (GlcNAc...) Potential
Experimental info
	Sequence conflict	55	1	M → V in AAR01130. Ref.3
	Sequence conflict	55	1	M → V in AAR01131. Ref.3
	Sequence conflict	55	1	M → V in AAR01132. Ref.3
	Sequence conflict	129	1	Q → R in AAR01130. Ref.3
	Sequence conflict	129	1	Q → R in AAR01131. Ref.3
	Sequence conflict	129	1	Q → R in AAR01132. Ref.3
	Sequence conflict	176	1	H → R in AAR01130. Ref.3
	Sequence conflict	176	1	H → R in AAR01131. Ref.3
	Sequence conflict	176	1	H → R in AAR01132. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q8WTE7 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: F60D7D7BD93D37F2	FASTA	417	48,520
	10 20 30 40 50 60 MKLNKLNPRW DAYDRRDSFW LQLLCLKYLG LWPPEDTDQA TRNRYIAYGW ALRIMFLHLY 70 80 90 100 110 120 ALTQALYFKD VKDINDIANA LFVLMTQVTL IYKLEKFNYN IARIQACLRK LNCTLYHPKQ 130 140 150 160 170 180 REEFSPVLQS MSGVFWLMIF LMFVAIFTII MWVMSPAFDN ERRLPVPAWF PVDYHHSDIV 190 200 210 220 230 240 YGVLFLYQTI GIVMSATYNF STDTMFSGLM LHINGQIVRL GSMVKKLGHD VPPERQLVAT 250 260 270 280 290 300 DAEWKEMRKR IDHHSKVYGT MYAKVTECVL FHKDILSFGD EVQDIFQGSI FAQVCASVII 310 320 330 340 350 360 ICMTLLQATG DDVTMADLLG CGFYLLVMTS QVFIFCYVGN EISYTTDKFT EFVGFSNYFK 370 380 390 400 410 FDKRTSQAMI FFLQMTLKDV HIKVGSVLKV TLNLHTFLQI MKLSYSYLAV LQSMESE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Candidate odorant receptors from the malaria vector mosquito Anopheles gambiae and evidence of down-regulation in response to blood feeding." Fox A.N., Pitts R.J., Robertson H.M., Carlson J.R., Zwiebel L.J. Proc. Natl. Acad. Sci. U.S.A. 98:14693-14697(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, INDUCTION, TISSUE SPECIFICITY. Strain: G3.
[2]	"The genome sequence of the malaria mosquito Anopheles gambiae." Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R., Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R., Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z., Kraft C.L., Abril J.F. , Anthouard V., Arensburger P., Atkinson P.W., Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C., Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K., Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V., Dana A., Delcher A., Dew I., Evans C.A., Flanigan M., Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R., Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J., Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I., Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A., McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D., O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H., Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J., Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B., Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M., Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I., Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J., Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M., Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C., Collins F.H., Hoffman S.L. Science 298:129-149(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PEST.
[3]	"Intraspecific nucleotide variation in Anopheles gambiae: new insights into the biology of malaria vectors." Morlais I., Poncon N., Simard F., Cohuet A., Fontenille D. Am. J. Trop. Med. Hyg. 71:795-802(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-236. Strain: 4aRR, L3-5 and Yaounde.
[4]	"Olfaction: mosquito receptor for human-sweat odorant." Hallem E.A., Fox A.N., Zwiebel L.J., Carlson J.R. Nature 427:212-213(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INDUCTION.
[5]	"G protein-coupled receptors in Anopheles gambiae." Hill C.A., Fox A.N., Pitts R.J., Kent L.B., Tan P.L., Chrystal M.A., Cravchik A., Collins F.H., Robertson H.M., Zwiebel L.J. Science 298:176-178(2002) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION, TISSUE SPECIFICITY.

Web resources

Protein Spotlight

What mosquitoes sniff - Issue 44 of March 2004

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF364130 Genomic DNA. Translation: AAL35506.1. AAAB01008980 Genomic DNA. Translation: EAA13838.1. AY334005 Genomic DNA. Translation: AAR01130.1. AY334006 Genomic DNA. Translation: AAR01131.1. AY334007 Genomic DNA. Translation: AAR01132.1.
RefSeq	XP_318674.1. XM_318674.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	AGAP009640-RA; AGAP009640-PA; AGAP009640.
GeneID	1279017.
KEGG	aga:AgaP_AGAP009640.
VectorBase	AGAP009639. Anopheles gambiae.
Organism-specific databases
CTD	1279017.
Phylogenomic databases
eggNOG	NOG327334.
HOGENOM	HOG000044066.
InParanoid	Q6VPM5.
KO	K08471.
OMA	NDIRTSK.
OrthoDB	EOG48SF8K.
PhylomeDB	Q8WTE7.
Family and domain databases
InterPro	IPR004117. 7tm6_olfct_rcpt. [Graphical view]
PANTHER	PTHR21137. PTHR21137. 1 hit.
Pfam	PF02949. 7tm_6. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

OR1_ANOGA

Accession

Primary (citable) accession number: Q8WTE7
Secondary accession number(s): Q6VPM5, Q7Q1T3

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 1, 2004
Last sequence update:	March 1, 2002
Last modified:	April 3, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)