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Protein

Odorant receptor Or1

Gene

OR1

Organism
Anopheles gambiae (African malaria mosquito)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor which plays a critical role in the anthropophilic host-seeking behavior; establishes the host preference to transmit malaria. May participate in the phenomenon of decreased host-seeking behavior in disease vector mosquitoes after blood feeding.2 Publications

GO - Molecular functioni

  • odorant binding Source: UniProtKB
  • olfactory receptor activity Source: UniProtKB

GO - Biological processi

  • detection of chemical stimulus involved in sensory perception of smell Source: GOC
  • olfactory behavior Source: UniProtKB
  • sensory perception of smell Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Names & Taxonomyi

Protein namesi
Recommended name:
Odorant receptor Or1
Alternative name(s):
AgOr1
Gene namesi
Name:OR1
ORF Names:AGAP009640
OrganismiAnopheles gambiae (African malaria mosquito)Imported
Taxonomic identifieri7165 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeAnophelinaeAnopheles
ProteomesiUP000007062 Componenti: Chromosome 3R

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 22CytoplasmicSequence Analysis
Transmembranei3 – 2321Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini24 – 4522ExtracellularSequence AnalysisAdd
BLAST
Transmembranei46 – 6621Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini67 – 737CytoplasmicSequence Analysis
Transmembranei74 – 9421Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini95 – 13339ExtracellularSequence AnalysisAdd
BLAST
Transmembranei134 – 15421Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini155 – 17824CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei179 – 19921Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini200 – 28485ExtracellularSequence AnalysisAdd
BLAST
Transmembranei285 – 30521Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini306 – 31712CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei318 – 33821Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini339 – 41779ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 417417Odorant receptor Or1PRO_0000174286Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi112 – 1121N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Expressioni

Tissue specificityi

Female-specific antennae and maxillary palp expression.2 Publications

Inductioni

Strong response to the odorant 4-methylphenol, a component of human sweat, when expressed in odorant receptor deficient Drosophila. In vivo, decreased expression in antennae after a blood meal.2 Publications

Interactioni

Protein-protein interaction databases

STRINGi7165.AGAP009640-PA.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG327334.
HOGENOMiHOG000044066.
InParanoidiQ8WTE7.
KOiK08471.
OMAiYNIARIQ.
OrthoDBiEOG73Z2T8.
PhylomeDBiQ8WTE7.

Family and domain databases

InterProiIPR004117. 7tm6_olfct_rcpt.
[Graphical view]
PANTHERiPTHR21137. PTHR21137. 1 hit.
PfamiPF02949. 7tm_6. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WTE7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLNKLNPRW DAYDRRDSFW LQLLCLKYLG LWPPEDTDQA TRNRYIAYGW
60 70 80 90 100
ALRIMFLHLY ALTQALYFKD VKDINDIANA LFVLMTQVTL IYKLEKFNYN
110 120 130 140 150
IARIQACLRK LNCTLYHPKQ REEFSPVLQS MSGVFWLMIF LMFVAIFTII
160 170 180 190 200
MWVMSPAFDN ERRLPVPAWF PVDYHHSDIV YGVLFLYQTI GIVMSATYNF
210 220 230 240 250
STDTMFSGLM LHINGQIVRL GSMVKKLGHD VPPERQLVAT DAEWKEMRKR
260 270 280 290 300
IDHHSKVYGT MYAKVTECVL FHKDILSFGD EVQDIFQGSI FAQVCASVII
310 320 330 340 350
ICMTLLQATG DDVTMADLLG CGFYLLVMTS QVFIFCYVGN EISYTTDKFT
360 370 380 390 400
EFVGFSNYFK FDKRTSQAMI FFLQMTLKDV HIKVGSVLKV TLNLHTFLQI
410
MKLSYSYLAV LQSMESE
Length:417
Mass (Da):48,520
Last modified:March 1, 2002 - v1
Checksum:iF60D7D7BD93D37F2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti55 – 551M → V in AAR01130 (PubMed:15642974).Curated
Sequence conflicti55 – 551M → V in AAR01131 (PubMed:15642974).Curated
Sequence conflicti55 – 551M → V in AAR01132 (PubMed:15642974).Curated
Sequence conflicti129 – 1291Q → R in AAR01130 (PubMed:15642974).Curated
Sequence conflicti129 – 1291Q → R in AAR01131 (PubMed:15642974).Curated
Sequence conflicti129 – 1291Q → R in AAR01132 (PubMed:15642974).Curated
Sequence conflicti176 – 1761H → R in AAR01130 (PubMed:15642974).Curated
Sequence conflicti176 – 1761H → R in AAR01131 (PubMed:15642974).Curated
Sequence conflicti176 – 1761H → R in AAR01132 (PubMed:15642974).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF364130 Genomic DNA. Translation: AAL35506.1.
AAAB01008980 Genomic DNA. Translation: EAA13838.1.
AY334005 Genomic DNA. Translation: AAR01130.1.
AY334006 Genomic DNA. Translation: AAR01131.1.
AY334007 Genomic DNA. Translation: AAR01132.1.
RefSeqiXP_318674.1. XM_318674.1.

Genome annotation databases

EnsemblMetazoaiAGAP009640-RA; AGAP009640-PA; AGAP009640.
GeneIDi1279017.
KEGGiaga:AgaP_AGAP009640.
VectorBaseiAGAP009639. Anopheles gambiae.

Cross-referencesi

Web resourcesi

Protein Spotlight

What mosquitoes sniff - Issue 44 of March 2004

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF364130 Genomic DNA. Translation: AAL35506.1.
AAAB01008980 Genomic DNA. Translation: EAA13838.1.
AY334005 Genomic DNA. Translation: AAR01130.1.
AY334006 Genomic DNA. Translation: AAR01131.1.
AY334007 Genomic DNA. Translation: AAR01132.1.
RefSeqiXP_318674.1. XM_318674.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7165.AGAP009640-PA.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiAGAP009640-RA; AGAP009640-PA; AGAP009640.
GeneIDi1279017.
KEGGiaga:AgaP_AGAP009640.
VectorBaseiAGAP009639. Anopheles gambiae.

Organism-specific databases

CTDi1279017.

Phylogenomic databases

eggNOGiNOG327334.
HOGENOMiHOG000044066.
InParanoidiQ8WTE7.
KOiK08471.
OMAiYNIARIQ.
OrthoDBiEOG73Z2T8.
PhylomeDBiQ8WTE7.

Family and domain databases

InterProiIPR004117. 7tm6_olfct_rcpt.
[Graphical view]
PANTHERiPTHR21137. PTHR21137. 1 hit.
PfamiPF02949. 7tm_6. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Candidate odorant receptors from the malaria vector mosquito Anopheles gambiae and evidence of down-regulation in response to blood feeding."
    Fox A.N., Pitts R.J., Robertson H.M., Carlson J.R., Zwiebel L.J.
    Proc. Natl. Acad. Sci. U.S.A. 98:14693-14697(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, INDUCTION, TISSUE SPECIFICITY.
    Strain: G31 Publication.
  2. "The genome sequence of the malaria mosquito Anopheles gambiae."
    Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R., Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R., Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z., Kraft C.L., Abril J.F.
    , Anthouard V., Arensburger P., Atkinson P.W., Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C., Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K., Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V., Dana A., Delcher A., Dew I., Evans C.A., Flanigan M., Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R., Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J., Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I., Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A., McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D., O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H., Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J., Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B., Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M., Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I., Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J., Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M., Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C., Collins F.H., Hoffman S.L.
    Science 298:129-149(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PEST.
  3. "Intraspecific nucleotide variation in Anopheles gambiae: new insights into the biology of malaria vectors."
    Morlais I., Poncon N., Simard F., Cohuet A., Fontenille D.
    Am. J. Trop. Med. Hyg. 71:795-802(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-236.
    Strain: 4aRR, L3-5 and Yaounde.
  4. "Olfaction: mosquito receptor for human-sweat odorant."
    Hallem E.A., Fox A.N., Zwiebel L.J., Carlson J.R.
    Nature 427:212-213(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION.
  5. Cited for: IDENTIFICATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiOR1_ANOGA
AccessioniPrimary (citable) accession number: Q8WTE7
Secondary accession number(s): Q6VPM5, Q7Q1T3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: March 1, 2002
Last modified: June 24, 2015
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.