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Q8WTE7 (OR1_ANOGA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Odorant receptor Or1
Alternative name(s):
AgOr1
Gene names
Name:OR1
ORF Names:AGAP009640
OrganismAnopheles gambiae (African malaria mosquito) [Reference proteome]
Taxonomic identifier7165 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeAnophelinaeAnopheles

Protein attributes

Sequence length417 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor which plays a critical role in the anthropophilic host-seeking behavior; establishes the host preference to transmit malaria. May participate in the phenomenon of decreased host-seeking behavior in disease vector mosquitoes after blood feeding. Ref.1 Ref.4

Subcellular location

Cell membrane; Multi-pass membrane protein Potential.

Tissue specificity

Female-specific antennae and maxillary palp expression. Ref.1 Ref.5

Induction

Strong response to the odorant 4-methylphenol, a component of human sweat, when expressed in odorant receptor deficient Drosophila. In vivo, decreased expression in antennae after a blood meal. Ref.1 Ref.4

Sequence similarities

Belongs to the insect chemoreceptor superfamily. Heteromeric odorant receptor channel (TC 1.A.69) family. Or2a subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 417417Odorant receptor Or1
PRO_0000174286

Regions

Topological domain1 – 22Cytoplasmic Potential
Transmembrane3 – 2321Helical; Name=1; Potential
Topological domain24 – 4522Extracellular Potential
Transmembrane46 – 6621Helical; Name=2; Potential
Topological domain67 – 737Cytoplasmic Potential
Transmembrane74 – 9421Helical; Name=3; Potential
Topological domain95 – 13339Extracellular Potential
Transmembrane134 – 15421Helical; Name=4; Potential
Topological domain155 – 17824Cytoplasmic Potential
Transmembrane179 – 19921Helical; Name=5; Potential
Topological domain200 – 28485Extracellular Potential
Transmembrane285 – 30521Helical; Name=6; Potential
Topological domain306 – 31712Cytoplasmic Potential
Transmembrane318 – 33821Helical; Name=7; Potential
Topological domain339 – 41779Extracellular Potential

Amino acid modifications

Glycosylation1121N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict551M → V in AAR01130. Ref.3
Sequence conflict551M → V in AAR01131. Ref.3
Sequence conflict551M → V in AAR01132. Ref.3
Sequence conflict1291Q → R in AAR01130. Ref.3
Sequence conflict1291Q → R in AAR01131. Ref.3
Sequence conflict1291Q → R in AAR01132. Ref.3
Sequence conflict1761H → R in AAR01130. Ref.3
Sequence conflict1761H → R in AAR01131. Ref.3
Sequence conflict1761H → R in AAR01132. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q8WTE7 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: F60D7D7BD93D37F2

FASTA41748,520
        10         20         30         40         50         60 
MKLNKLNPRW DAYDRRDSFW LQLLCLKYLG LWPPEDTDQA TRNRYIAYGW ALRIMFLHLY 

        70         80         90        100        110        120 
ALTQALYFKD VKDINDIANA LFVLMTQVTL IYKLEKFNYN IARIQACLRK LNCTLYHPKQ 

       130        140        150        160        170        180 
REEFSPVLQS MSGVFWLMIF LMFVAIFTII MWVMSPAFDN ERRLPVPAWF PVDYHHSDIV 

       190        200        210        220        230        240 
YGVLFLYQTI GIVMSATYNF STDTMFSGLM LHINGQIVRL GSMVKKLGHD VPPERQLVAT 

       250        260        270        280        290        300 
DAEWKEMRKR IDHHSKVYGT MYAKVTECVL FHKDILSFGD EVQDIFQGSI FAQVCASVII 

       310        320        330        340        350        360 
ICMTLLQATG DDVTMADLLG CGFYLLVMTS QVFIFCYVGN EISYTTDKFT EFVGFSNYFK 

       370        380        390        400        410 
FDKRTSQAMI FFLQMTLKDV HIKVGSVLKV TLNLHTFLQI MKLSYSYLAV LQSMESE 

« Hide

References

« Hide 'large scale' references
[1]"Candidate odorant receptors from the malaria vector mosquito Anopheles gambiae and evidence of down-regulation in response to blood feeding."
Fox A.N., Pitts R.J., Robertson H.M., Carlson J.R., Zwiebel L.J.
Proc. Natl. Acad. Sci. U.S.A. 98:14693-14697(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, INDUCTION, TISSUE SPECIFICITY.
Strain: G3.
[2]"The genome sequence of the malaria mosquito Anopheles gambiae."
Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R., Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R., Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z., Kraft C.L., Abril J.F. expand/collapse author list , Anthouard V., Arensburger P., Atkinson P.W., Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C., Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K., Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V., Dana A., Delcher A., Dew I., Evans C.A., Flanigan M., Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R., Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J., Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I., Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A., McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D., O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H., Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J., Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B., Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M., Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I., Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J., Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M., Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C., Collins F.H., Hoffman S.L.
Science 298:129-149(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PEST.
[3]"Intraspecific nucleotide variation in Anopheles gambiae: new insights into the biology of malaria vectors."
Morlais I., Poncon N., Simard F., Cohuet A., Fontenille D.
Am. J. Trop. Med. Hyg. 71:795-802(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-236.
Strain: 4aRR, L3-5 and Yaounde.
[4]"Olfaction: mosquito receptor for human-sweat odorant."
Hallem E.A., Fox A.N., Zwiebel L.J., Carlson J.R.
Nature 427:212-213(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INDUCTION.
[5]"G protein-coupled receptors in Anopheles gambiae."
Hill C.A., Fox A.N., Pitts R.J., Kent L.B., Tan P.L., Chrystal M.A., Cravchik A., Collins F.H., Robertson H.M., Zwiebel L.J.
Science 298:176-178(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION, TISSUE SPECIFICITY.

Web resources

Protein Spotlight

What mosquitoes sniff - Issue 44 of March 2004

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF364130 Genomic DNA. Translation: AAL35506.1.
AAAB01008980 Genomic DNA. Translation: EAA13838.1.
AY334005 Genomic DNA. Translation: AAR01130.1.
AY334006 Genomic DNA. Translation: AAR01131.1.
AY334007 Genomic DNA. Translation: AAR01132.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaAGAP009640-RA; AGAP009640-PA; AGAP009640.
KEGGaga:AgaP_AGAP009640.
VectorBaseAGAP009639. Anopheles gambiae.

Organism-specific databases

CTD1279017.

Phylogenomic databases

eggNOGNOG327334.
HOGENOMHOG000044066.
InParanoidQ6VPM5.
KOK08471.
OMANDIRTSK.
OrthoDBEOG73Z2T8.
PhylomeDBQ8WTE7.

Family and domain databases

InterProIPR004117. 7tm6_olfct_rcpt.
[Graphical view]
PANTHERPTHR21137. PTHR21137. 1 hit.
PfamPF02949. 7tm_6. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameOR1_ANOGA
AccessionPrimary (citable) accession number: Q8WTE7
Secondary accession number(s): Q6VPM5, Q7Q1T3
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: March 1, 2002
Last modified: April 16, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries