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Protein

Odorant receptor Or1

Gene

OR1

Organism
Anopheles gambiae (African malaria mosquito)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor which plays a critical role in the anthropophilic host-seeking behavior; establishes the host preference to transmit malaria. May participate in the phenomenon of decreased host-seeking behavior in disease vector mosquitoes after blood feeding.2 Publications

GO - Molecular functioni

  • odorant binding Source: UniProtKB
  • olfactory receptor activity Source: UniProtKB

GO - Biological processi

  • olfactory behavior Source: UniProtKB
  • sensory perception of smell Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Names & Taxonomyi

Protein namesi
Recommended name:
Odorant receptor Or1
Alternative name(s):
AgOr1
Gene namesi
Name:OR1
ORF Names:AGAP009640
OrganismiAnopheles gambiae (African malaria mosquito)Imported
Taxonomic identifieri7165 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeAnophelinaeAnopheles
Proteomesi
  • UP000007062 Componentsi: Chromosome 3R, Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 2CytoplasmicSequence analysis2
Transmembranei3 – 23Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini24 – 45ExtracellularSequence analysisAdd BLAST22
Transmembranei46 – 66Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini67 – 73CytoplasmicSequence analysis7
Transmembranei74 – 94Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini95 – 133ExtracellularSequence analysisAdd BLAST39
Transmembranei134 – 154Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini155 – 178CytoplasmicSequence analysisAdd BLAST24
Transmembranei179 – 199Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini200 – 284ExtracellularSequence analysisAdd BLAST85
Transmembranei285 – 305Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini306 – 317CytoplasmicSequence analysisAdd BLAST12
Transmembranei318 – 338Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini339 – 417ExtracellularSequence analysisAdd BLAST79

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
  • plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001742861 – 417Odorant receptor Or1Add BLAST417

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi112N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8WTE7.

Expressioni

Tissue specificityi

Female-specific antennae and maxillary palp expression.2 Publications

Inductioni

Strong response to the odorant 4-methylphenol, a component of human sweat, when expressed in odorant receptor deficient Drosophila. In vivo, decreased expression in antennae after a blood meal.2 Publications

Interactioni

Protein-protein interaction databases

STRINGi7165.AGAP009640-PA.

Structurei

3D structure databases

ProteinModelPortaliQ8WTE7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410JDA5. Eukaryota.
ENOG410YKTV. LUCA.
HOGENOMiHOG000044066.
InParanoidiQ8WTE7.
KOiK08471.
OMAiFRENIRC.
OrthoDBiEOG091G09UE.
PhylomeDBiQ8WTE7.

Family and domain databases

InterProiIPR004117. 7tm6_olfct_rcpt.
[Graphical view]
PANTHERiPTHR21137. PTHR21137. 1 hit.
PfamiPF02949. 7tm_6. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WTE7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLNKLNPRW DAYDRRDSFW LQLLCLKYLG LWPPEDTDQA TRNRYIAYGW
60 70 80 90 100
ALRIMFLHLY ALTQALYFKD VKDINDIANA LFVLMTQVTL IYKLEKFNYN
110 120 130 140 150
IARIQACLRK LNCTLYHPKQ REEFSPVLQS MSGVFWLMIF LMFVAIFTII
160 170 180 190 200
MWVMSPAFDN ERRLPVPAWF PVDYHHSDIV YGVLFLYQTI GIVMSATYNF
210 220 230 240 250
STDTMFSGLM LHINGQIVRL GSMVKKLGHD VPPERQLVAT DAEWKEMRKR
260 270 280 290 300
IDHHSKVYGT MYAKVTECVL FHKDILSFGD EVQDIFQGSI FAQVCASVII
310 320 330 340 350
ICMTLLQATG DDVTMADLLG CGFYLLVMTS QVFIFCYVGN EISYTTDKFT
360 370 380 390 400
EFVGFSNYFK FDKRTSQAMI FFLQMTLKDV HIKVGSVLKV TLNLHTFLQI
410
MKLSYSYLAV LQSMESE
Length:417
Mass (Da):48,520
Last modified:March 1, 2002 - v1
Checksum:iF60D7D7BD93D37F2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti55M → V in AAR01130 (PubMed:15642974).Curated1
Sequence conflicti55M → V in AAR01131 (PubMed:15642974).Curated1
Sequence conflicti55M → V in AAR01132 (PubMed:15642974).Curated1
Sequence conflicti129Q → R in AAR01130 (PubMed:15642974).Curated1
Sequence conflicti129Q → R in AAR01131 (PubMed:15642974).Curated1
Sequence conflicti129Q → R in AAR01132 (PubMed:15642974).Curated1
Sequence conflicti176H → R in AAR01130 (PubMed:15642974).Curated1
Sequence conflicti176H → R in AAR01131 (PubMed:15642974).Curated1
Sequence conflicti176H → R in AAR01132 (PubMed:15642974).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF364130 Genomic DNA. Translation: AAL35506.1.
AAAB01008980 Genomic DNA. Translation: EAA13838.1.
AY334005 Genomic DNA. Translation: AAR01130.1.
AY334006 Genomic DNA. Translation: AAR01131.1.
AY334007 Genomic DNA. Translation: AAR01132.1.
RefSeqiXP_318674.1. XM_318674.1.

Genome annotation databases

EnsemblMetazoaiAGAP009640-RA; AGAP009640-PA; AGAP009640.
GeneIDi1279017.
KEGGiaga:AgaP_AGAP009640.
VectorBaseiAGAP009640-RA; AGAP009640-PA; AGAP009640.

Cross-referencesi

Web resourcesi

Protein Spotlight

What mosquitoes sniff - Issue 44 of March 2004

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF364130 Genomic DNA. Translation: AAL35506.1.
AAAB01008980 Genomic DNA. Translation: EAA13838.1.
AY334005 Genomic DNA. Translation: AAR01130.1.
AY334006 Genomic DNA. Translation: AAR01131.1.
AY334007 Genomic DNA. Translation: AAR01132.1.
RefSeqiXP_318674.1. XM_318674.1.

3D structure databases

ProteinModelPortaliQ8WTE7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7165.AGAP009640-PA.

Proteomic databases

PaxDbiQ8WTE7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiAGAP009640-RA; AGAP009640-PA; AGAP009640.
GeneIDi1279017.
KEGGiaga:AgaP_AGAP009640.
VectorBaseiAGAP009640-RA; AGAP009640-PA; AGAP009640.

Organism-specific databases

CTDi1279017.

Phylogenomic databases

eggNOGiENOG410JDA5. Eukaryota.
ENOG410YKTV. LUCA.
HOGENOMiHOG000044066.
InParanoidiQ8WTE7.
KOiK08471.
OMAiFRENIRC.
OrthoDBiEOG091G09UE.
PhylomeDBiQ8WTE7.

Family and domain databases

InterProiIPR004117. 7tm6_olfct_rcpt.
[Graphical view]
PANTHERiPTHR21137. PTHR21137. 1 hit.
PfamiPF02949. 7tm_6. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR1_ANOGA
AccessioniPrimary (citable) accession number: Q8WTE7
Secondary accession number(s): Q6VPM5, Q7Q1T3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: March 1, 2002
Last modified: November 30, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.