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Reviewed, UniProtKB/Swiss-Prot Q8WTE7 (OR1_ANOGA)

Last modified September 2, 2008. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Odorant receptor Or1
Alternative name(s):
    AgOr1
Gene names
Name: OR1
ORF Names: AGAP009640
OrganismAnopheles gambiae (African malaria mosquito) [Complete proteome]
Taxonomic identifier7165 [NCBI]
Taxonomic lineageEukaryotaMetazoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeAnophelinaeAnopheles

Protein attributes

Sequence length417 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Plays a critical role in the anthropophilic host-seeking behavior; establishes the host preference to transmit malaria. May participate in the phenomenon of decreased host-seeking behavior in disease vector mosquitoes after blood feeding.

Subcellular location

Cell membrane; Multi-pass membrane proteinPotential.

Tissue specificity

Female-specific antennas and maxillary palp expression.

Induction

Strong response to the odorant 4-methylphenol, a component of human sweat, when expressed in odorant receptor deficient Drosophila. In vivo, decreased expression in antennas after a blood meal.

Sequence similarities

Belongs to the G-protein coupled receptor 6 family.

Ontologies

Keywords

   Biological processOlfaction
Sensory transduction
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   Technical termComplete proteome

Gene Ontology (GO)

   Biological processolfactory behavior Ref.4

Inferred from direct assay. Source: UniProtKB

sensory perception of smell Ref.4

Inferred from direct assay. Source: UniProtKB

   Cellular componentintegral to membrane Ref.4

Non-traceable author statement. Source: UniProtKB

   Molecular functionodorant binding Ref.4

Inferred from direct assay. Source: UniProtKB

olfactory receptor activity Ref.4

Inferred from direct assay. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical view

Molecule processing

Chain1 – 417417Odorant receptor Or1

Regions

Topological domain1 – 22Extracellular Potential
Transmembrane3 – 23211 Potential
Topological domain24 – 4522Cytoplasmic Potential
Transmembrane46 – 66212 Potential
Topological domain67 – 737Extracellular Potential
Transmembrane74 – 94213 Potential
Topological domain95 – 13339Cytoplasmic Potential
Transmembrane134 – 154214 Potential
Topological domain155 – 17824Extracellular Potential
Transmembrane179 – 199215 Potential
Topological domain200 – 28485Cytoplasmic Potential
Transmembrane285 – 305216 Potential
Topological domain306 – 31712Extracellular Potential
Transmembrane318 – 338217 Potential
Topological domain339 – 41779Cytoplasmic Potential

Experimental info

Sequence conflict551M → V in AAR01130, AAR01131 and AAR01132. Ref.3
Sequence conflict1291Q → R in AAR01130, AAR01131 and AAR01132. Ref.3
Sequence conflict1761H → R in AAR01130, AAR01131 and AAR01132. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q8WTE7-1 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: F60D7D7BD93D37F2

FASTA41748,520
        10         20         30         40         50         60 
MKLNKLNPRW DAYDRRDSFW LQLLCLKYLG LWPPEDTDQA TRNRYIAYGW ALRIMFLHLY 

        70         80         90        100        110        120 
ALTQALYFKD VKDINDIANA LFVLMTQVTL IYKLEKFNYN IARIQACLRK LNCTLYHPKQ 

       130        140        150        160        170        180 
REEFSPVLQS MSGVFWLMIF LMFVAIFTII MWVMSPAFDN ERRLPVPAWF PVDYHHSDIV 

       190        200        210        220        230        240 
YGVLFLYQTI GIVMSATYNF STDTMFSGLM LHINGQIVRL GSMVKKLGHD VPPERQLVAT 

       250        260        270        280        290        300 
DAEWKEMRKR IDHHSKVYGT MYAKVTECVL FHKDILSFGD EVQDIFQGSI FAQVCASVII 

       310        320        330        340        350        360 
ICMTLLQATG DDVTMADLLG CGFYLLVMTS QVFIFCYVGN EISYTTDKFT EFVGFSNYFK 

       370        380        390        400        410 
FDKRTSQAMI FFLQMTLKDV HIKVGSVLKV TLNLHTFLQI MKLSYSYLAV LQSMESE 

« Hide

References

« Hide 'large scale' references
[1]"Candidate odorant receptors from the malaria vector mosquito Anopheles gambiae and evidence of down-regulation in response to blood feeding."
Fox A.N., Pitts R.J., Robertson H.M., Carlson J.R., Zwiebel L.J.
Proc. Natl. Acad. Sci. U.S.A. 98:14693-14697(2001) [PubMed: 11724964] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, INDUCTION, TISSUE SPECIFICITY.
Strain: G3.
[2]"The genome sequence of the malaria mosquito Anopheles gambiae."
Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R., Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R., Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z., Kraft C.L., Abril J.F. expand/collapse author list , Anthouard V., Arensburger P., Atkinson P.W., Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C., Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K., Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V., Dana A., Delcher A., Dew I., Evans C.A., Flanigan M., Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R., Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J., Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I., Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A., McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D., O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H., Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J., Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B., Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M., Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I., Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J., Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M., Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C., Collins F.H., Hoffman S.L.
Science 298:129-149(2002) [PubMed: 12364791] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PEST.
[3]"Intraspecific nucleotide variation in Anopheles gambiae: new insights into the biology of malaria vectors."
Morlais I., Poncon N., Simard F., Cohuet A., Fontenille D.
Am. J. Trop. Med. Hyg. 71:795-802(2004) [PubMed: 15642974] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-236.
Strain: 4aRR, L3-5 and Yaounde.
[4]"Olfaction: mosquito receptor for human-sweat odorant."
Hallem E.A., Fox A.N., Zwiebel L.J., Carlson J.R.
Nature 427:212-213(2004) [PubMed: 14724626] [Abstract]
Cited for: FUNCTION, INDUCTION.
[5]"G protein-coupled receptors in Anopheles gambiae."
Hill C.A., Fox A.N., Pitts R.J., Kent L.B., Tan P.L., Chrystal M.A., Cravchik A., Collins F.H., Robertson H.M., Zwiebel L.J.
Science 298:176-178(2002) [PubMed: 12364795] [Abstract]
Cited for: IDENTIFICATION, TISSUE SPECIFICITY.

Web resources

Protein Spotlight

What mosquitoes sniff - Issue 44 of March 2004

Cross-references

Sequence databases

AF364130 Genomic DNA. Translation: AAL35506.1.
AAAB01008980 Genomic DNA. Translation: EAA13838.1.
AY334005 Genomic DNA. Translation: AAR01130.1.
AY334006 Genomic DNA. Translation: AAR01131.1.
AY334007 Genomic DNA. Translation: AAR01132.1.
RefSeqXP_318674.1.

3D structure databases

ModBaseSearch...

Protein family/group databases

GPCRDBSearch...

Genome annotation databases

EnsemblAGAP009640. Anopheles gambiae. [Contig view]
GeneID1279017.
KEGGaga:AgaP_AGAP009640.
VectorBaseAGAP009639. Anopheles gambiae.

Phylogenomic databases

HOGENOMQ8WTE7.

Family and domain databases

InterProIPR004117. 7tm6_olfct_rcpt.
[Graphical view]
PANTHERPTHR21137. 7tm6_olfct_rcpt. 1 hit.
PfamPF02949. 7tm_6. 1 hit.
[Graphical view]
ProDomQ8WTE7.
[Graphical view] [Entries sharing at least one domain]
BLOCKSSearch...

Other Resources

ProtoNetSearch...

Entry information

Entry nameOR1_ANOGA
AccessionPrimary (citable) accession number: Q8WTE7
Secondary accession number(s): Q6VPM5, Q7Q1T3
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: March 1, 2002
Last modified: September 2, 2008
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

UniProtKB secondary accession numbers

Index of UniProtKB secondary accession numbers

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents