Reviewed,
UniProtKB/Swiss-Prot Q8WTE7 (OR1_ANOGA)
Last modified
January 19, 2010.
Version 55.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Odorant receptor Or1 Alternative name(s): AgOr1 | ||||
| Gene names |
| ||||
| Organism | Anopheles gambiae (African malaria mosquito) [Complete proteome] | ||||
| Taxonomic identifier | 7165 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Nematocera › Culicoidea › Culicidae › Anophelinae › Anopheles |
Protein attributes
| Sequence length | 417 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Plays a critical role in the anthropophilic host-seeking behavior; establishes the host preference to transmit malaria. May participate in the phenomenon of decreased host-seeking behavior in disease vector mosquitoes after blood feeding. Ref.1 Ref.4 |
| Subcellular location | Cell membrane; Multi-pass membrane protein Potential. |
| Tissue specificity | Female-specific antennas and maxillary palp expression. Ref.1 Ref.5 |
| Induction | Strong response to the odorant 4-methylphenol, a component of human sweat, when expressed in odorant receptor deficient Drosophila. In vivo, decreased expression in antennas after a blood meal. Ref.1 Ref.4 |
| Sequence similarities | Belongs to the odorant-gated ionic channel family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Olfaction Sensory transduction |
| Cellular component | Cell membrane Membrane |
| Domain | Transmembrane |
| Molecular function | G-protein coupled receptor Receptor Transducer |
| PTM | Glycoprotein |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | G-protein coupled receptor protein signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW olfactory behavior Ref.4Inferred from direct assay. Source: UniProtKB sensory perception of smell Ref.4Inferred from direct assay. Source: UniProtKB |
| Cellular component | integral to membrane Ref.4 Non-traceable author statement. Source: UniProtKB plasma membraneInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | odorant binding Ref.4 Inferred from direct assay. Source: UniProtKB olfactory receptor activity Ref.4Inferred from direct assay. Source: UniProtKB |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 417 | 417 | Odorant receptor Or1 | PRO_0000174286 | |||||
Regions | |||||||||
| Topological domain | 1 – 2 | 2 | Cytoplasmic Potential | ||||||
| Transmembrane | 3 – 23 | 21 | 1 Potential | ||||||
| Topological domain | 24 – 45 | 22 | Extracellular Potential | ||||||
| Transmembrane | 46 – 66 | 21 | 2 Potential | ||||||
| Topological domain | 67 – 73 | 7 | Cytoplasmic Potential | ||||||
| Transmembrane | 74 – 94 | 21 | 3 Potential | ||||||
| Topological domain | 95 – 133 | 39 | Extracellular Potential | ||||||
| Transmembrane | 134 – 154 | 21 | 4 Potential | ||||||
| Topological domain | 155 – 178 | 24 | Cytoplasmic Potential | ||||||
| Transmembrane | 179 – 199 | 21 | 5 Potential | ||||||
| Topological domain | 200 – 284 | 85 | Extracellular Potential | ||||||
| Transmembrane | 285 – 305 | 21 | 6 Potential | ||||||
| Topological domain | 306 – 317 | 12 | Cytoplasmic Potential | ||||||
| Transmembrane | 318 – 338 | 21 | 7 Potential | ||||||
| Topological domain | 339 – 417 | 79 | Extracellular Potential | ||||||
Amino acid modifications | |||||||||
| Glycosylation | 112 | 1 | N-linked (GlcNAc...) Potential | ||||||
Experimental info | |||||||||
| Sequence conflict | 55 | 1 | M → V in AAR01130. Ref.3 | ||||||
| Sequence conflict | 55 | 1 | M → V in AAR01131. Ref.3 | ||||||
| Sequence conflict | 55 | 1 | M → V in AAR01132. Ref.3 | ||||||
| Sequence conflict | 129 | 1 | Q → R in AAR01130. Ref.3 | ||||||
| Sequence conflict | 129 | 1 | Q → R in AAR01131. Ref.3 | ||||||
| Sequence conflict | 129 | 1 | Q → R in AAR01132. Ref.3 | ||||||
| Sequence conflict | 176 | 1 | H → R in AAR01130. Ref.3 | ||||||
| Sequence conflict | 176 | 1 | H → R in AAR01131. Ref.3 | ||||||
| Sequence conflict | 176 | 1 | H → R in AAR01132. Ref.3 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Candidate odorant receptors from the malaria vector mosquito Anopheles gambiae and evidence of down-regulation in response to blood feeding." Fox A.N., Pitts R.J., Robertson H.M., Carlson J.R., Zwiebel L.J. Proc. Natl. Acad. Sci. U.S.A. 98:14693-14697(2001) [PubMed: 11724964] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, INDUCTION, TISSUE SPECIFICITY. Strain: G3. |
| [2] | "The genome sequence of the malaria mosquito Anopheles gambiae." Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R., Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R., Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z., Kraft C.L., Abril J.F. Hoffman S.L.Science 298:129-149(2002) [PubMed: 12364791] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: PEST. |
| [3] | "Intraspecific nucleotide variation in Anopheles gambiae: new insights into the biology of malaria vectors." Morlais I., Poncon N., Simard F., Cohuet A., Fontenille D. Am. J. Trop. Med. Hyg. 71:795-802(2004) [PubMed: 15642974] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 35-236. Strain: 4aRR, L3-5 and Yaounde. |
| [4] | "Olfaction: mosquito receptor for human-sweat odorant." Hallem E.A., Fox A.N., Zwiebel L.J., Carlson J.R. Nature 427:212-213(2004) [PubMed: 14724626] [Abstract] Cited for: FUNCTION, INDUCTION. |
| [5] | "G protein-coupled receptors in Anopheles gambiae." Hill C.A., Fox A.N., Pitts R.J., Kent L.B., Tan P.L., Chrystal M.A., Cravchik A., Collins F.H., Robertson H.M., Zwiebel L.J. Science 298:176-178(2002) [PubMed: 12364795] [Abstract] Cited for: IDENTIFICATION, TISSUE SPECIFICITY. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AF364130 Genomic DNA. Translation: AAL35506.1. AAAB01008980 Genomic DNA. Translation: EAA13838.1. AY334005 Genomic DNA. Translation: AAR01130.1. AY334006 Genomic DNA. Translation: AAR01131.1. AY334007 Genomic DNA. Translation: AAR01132.1. |
| RefSeq | XP_318674.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1279017. |
| KEGG | aga:AgaP_AGAP009640. |
| VectorBase | AGAP009639. Anopheles gambiae. |
Organism-specific databases | |
| CTD | 1279017. |
Phylogenomic databases | |
| InParanoid | Q8WTE7. |
| OrthoDB | EOG9CG0FJ. |
| PhylomeDB | Q8WTE7. |
Family and domain databases | |
| InterPro | IPR004117. 7tm6_olfct_rcpt. [Graphical view] |
| PANTHER | PTHR21137. 7tm6_olfct_rcpt. 1 hit. |
| Pfam | PF02949. 7tm_6. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | OR1_ANOGA | ||||||||
| Accession | Primary (citable) accession number: Q8WTE7 Secondary accession number(s): Q6VPM5, Q7Q1T3 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
Relevant documents
| Protein Spotlight Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries |
| SIMILARITY comments Index of protein domains and families |

Clusters with


