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Q8WSW3

- MTCD_TETTH

UniProt

Q8WSW3 - MTCD_TETTH

Protein

Cadmium metallothionein

Gene

MTT1

Organism
Tetrahymena thermophila
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    The metallothioneins are involved in the cellular sequestration of toxic metal ions.

    GO - Molecular functioni

    1. cadmium ion binding Source: InterPro

    Keywords - Ligandi

    Cadmium, Metal-binding, Metal-thiolate cluster

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cadmium metallothionein
    Alternative name(s):
    Cd-MT
    MT-Cd
    Gene namesi
    Name:MTT1
    OrganismiTetrahymena thermophila
    Taxonomic identifieri5911 [NCBI]
    Taxonomic lineageiEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaHymenostomatidaTetrahymeninaTetrahymenidaeTetrahymena

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Propeptidei1 – 221 PublicationPRO_0000018673
    Chaini3 – 162160Cadmium metallothioneinPRO_0000018674Add
    BLAST

    Expressioni

    Inductioni

    By cadmium, and to a lesser extent by mercury, copper, heat, hydrogen peroxide and IL-6.2 Publications

    Interactioni

    Protein-protein interaction databases

    STRINGi5911.Q8WSW3.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8WSW3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG85154.

    Family and domain databases

    InterProiIPR012484. Metalthion_7.
    [Graphical view]
    PfamiPF07846. Metallothio_Cad. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8WSW3-1 [UniParc]FASTAAdd to Basket

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    MDKVNSCCCG VNAKPCCTDP NSGCCCVSKT DNCCKSDTKE CCTGTGEGCK    50
    CVNCKCCKPQ ANCCCGVNAK PCCFDPNSGC CCVSKTNNCC KSDTKECCTG 100
    TGEGCKCTSC QCCKPVQQGC CCGDKAKACC TDPNSGCCCS NKANKCCDAT 150
    SKQECQTCQC CK 162
    Length:162
    Mass (Da):16,757
    Last modified:March 1, 2002 - v1
    Checksum:i9B2DB3C95981FFCD
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti6 – 61S → NN in AAP33500. 1 PublicationCurated
    Sequence conflicti156 – 1561Q → K in AAP33500. 1 PublicationCurated
    Sequence conflicti159 – 1591Q → E in AAP33500. 1 PublicationCurated

    Mass spectrometryi

    Molecular mass is 16763 Da from positions 3 - 162. Determined by MALDI. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY061892 Genomic DNA. Translation: AAL31645.1.
    AY740525 Genomic DNA. Translation: AAU87360.1.
    DQ517937 mRNA. Translation: ABF68755.1.
    EF195745 mRNA. Translation: ABN42648.1.
    DQ022186 mRNA. Translation: AAY42865.1.
    AY273793 mRNA. Translation: AAP33500.1.
    AF537326 mRNA. Translation: AAN06822.1.
    RefSeqiXP_001024888.1. XM_001024888.1.
    UniGeneiTth.4002.

    Genome annotation databases

    GeneIDi7828336.
    KEGGitet:TTHERM_00241640.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY061892 Genomic DNA. Translation: AAL31645.1 .
    AY740525 Genomic DNA. Translation: AAU87360.1 .
    DQ517937 mRNA. Translation: ABF68755.1 .
    EF195745 mRNA. Translation: ABN42648.1 .
    DQ022186 mRNA. Translation: AAY42865.1 .
    AY273793 mRNA. Translation: AAP33500.1 .
    AF537326 mRNA. Translation: AAN06822.1 .
    RefSeqi XP_001024888.1. XM_001024888.1.
    UniGenei Tth.4002.

    3D structure databases

    ProteinModelPortali Q8WSW3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5911.Q8WSW3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 7828336.
    KEGGi tet:TTHERM_00241640.

    Phylogenomic databases

    eggNOGi NOG85154.

    Family and domain databases

    InterProi IPR012484. Metalthion_7.
    [Graphical view ]
    Pfami PF07846. Metallothio_Cad. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A robust inducible-repressible promoter greatly facilitates gene knockouts, conditional expression, and overexpression of homologous and heterologous genes in Tetrahymena thermophila."
      Shang Y., Song X., Bowen J., Corstanje R., Gao Y., Gaertig J., Gorovsky M.A.
      Proc. Natl. Acad. Sci. U.S.A. 99:3734-3739(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], INDUCTION.
      Strain: CU428.
    2. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
      Strain: Inbred strain B and SB1969.
    3. "Evolution of metallothioneins in Tetrahymena thermophila."
      Formigari A., Santovito G., Boldrin F., Irato P., Piccinni E.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Inbred B.
    4. "Tetrahymena thermophila cadmium metallothionein gene."
      Miao W., Wan M., Song Y.
      Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-162.
    5. "Biochemical characterization and quantitative gene expression analysis of the multi-stress inducible metallothionein from Tetrahymena thermophila."
      Dondero F., Cavaletto M., Ghezzi A.R., La Terza A., Banni M., Viarengo A.
      Protist 155:157-168(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 7-162, PROTEIN SEQUENCE OF 3-17, INDUCTION, MASS SPECTROMETRY.
      Strain: CU428.

    Entry informationi

    Entry nameiMTCD_TETTH
    AccessioniPrimary (citable) accession number: Q8WSW3
    Secondary accession number(s): Q5XQF6, Q86BU0, Q8IT78
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 16, 2003
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. Metallothioneins
      Classification of metallothioneins and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3