Reviewed,
UniProtKB/Swiss-Prot Q8WSR7 (CTNB_DICDI)
Last modified
July 22, 2008.
Version 26.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Countin-2 | ||||
| Gene names |
| ||||
| Organism | Dictyostelium discoideum (Slime mold) [Complete proteome] | ||||
| Taxonomic identifier | 44689 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Mycetozoa › Dictyosteliida › Dictyostelium |
Protein attributes
| Sequence length | 254 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Cell-counting factor that limits the minimum size of the multicellular structure. May up-regulate the expression of both gp24 and gp80, which mediate cell adhesion. |
| Subcellular location | |
| Developmental stage | Expressed in the vegetative cells. Increases during aggregation to mound stages (6-12 hours) and decreases at late developmental stages (18-24 hours). |
| Miscellaneous | Cells lacking cntB form a higher number of smaller aggregates. |
| Sequence similarities | Belongs to the countin family. Contains 1 saposin B-type domain. |
Ontologies
Keywords | |
|---|---|
| Cellular component | Secreted |
| Domain | Signal |
| PTM | Glycoprotein |
| Technical term | Complete proteome |
Gene Ontology (GO) | |
| None. [Check GOA] | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | ||||||
Molecule processing | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 19 | 19 | Potential | |||||||
| Chain | 20 – 254 | 235 | Countin-2 | |||||||
Regions | ||||||||||
| Domain | 22 – 107 | 86 | Saposin B-type | |||||||
Amino acid modifications | ||||||||||
| Glycosylation | 110 | 1 | N-linked (GlcNAc...) Potential | |||||||
| Glycosylation | 219 | 1 | N-linked (GlcNAc...) Potential | |||||||
| Disulfide bond | 26 ↔ 103 | By similarity | ||||||||
| Disulfide bond | 29 ↔ 97 | By similarity | ||||||||
| Disulfide bond | 56 ↔ 68 | By similarity | ||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Two cell-counting factors regulate the aggregate size of the cellular slime mold Dictyostelium discoideum." Okuwa T., Katayama T., Takano A., Kodaira K., Yasukawa H. Dev. Growth Differ. 43:735-744(2001) [PubMed: 11737154] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE, SUBCELLULAR LOCATION, KNOCKOUT. |
| [2] | "The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. Kuspa A.Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4. |
Cross-references
Sequence databases | |
|---|---|
| AB067573 mRNA. Translation: BAB84187.1. AAFI02000033 Genomic DNA. Translation: EAL67512.1. | |
| RefSeq | XP_641512.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 3392606. |
| KEGG | ddi:DDB_0214993. |
Organism-specific databases | |
| dictyBase | DDB0214993. ctnB. |
Family and domain databases | |
| InterPro | IPR008139. SaposinB. [Graphical view] |
| SMART | SM00741. SapB. 1 hit. [Graphical view] |
| PROSITE | PS50015. SAP_B. 1 hit. [Graphical view] |
| ProDom | Q8WSR7. [Graphical view] [Entries sharing at least one domain] |
| BLOCKS | Search... |
Other Resources | |
| ProtoNet | Search... |
Entry information
| Entry name | CTNB_DICDI | ||||||||
| Accession | Primary (citable) accession number: Q8WSR7 Secondary accession number(s): Q54W80 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
Relevant documents
| Dictyostelium discoideum Dictyostelium discoideum: entries, gene names and cross-references to dictyBase |
| UniProtKB secondary accession numbers Index of UniProtKB secondary accession numbers |
| SIMILARITY comments Index of protein domains and families |

Clusters with


