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Q8WSR7

- CTNB_DICDI

UniProt

Q8WSR7 - CTNB_DICDI

Protein

Countin-2

Gene

ctnB

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Cell-counting factor that limits the minimum size of the multicellular structure. May up-regulate the expression of both gp24 and gp80, which mediate cell adhesion.1 Publication

    GO - Biological processi

    1. aggregation involved in sorocarp development Source: dictyBase
    2. single organismal cell-cell adhesion Source: dictyBase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Countin-2
    Gene namesi
    Name:ctnB
    ORF Names:DDB_G0279797
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Chromosome 3, UP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0279797. ctnB.

    Subcellular locationi

    Secreted 1 Publication

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Disruption phenotypei

    Cells form a higher number of smaller aggregates.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 254235Countin-2PRO_0000327909Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi26 ↔ 103PROSITE-ProRule annotation
    Disulfide bondi29 ↔ 97PROSITE-ProRule annotation
    Disulfide bondi56 ↔ 68PROSITE-ProRule annotation
    Glycosylationi110 – 1101N-linked (GlcNAc...)PROSITE-ProRule annotation
    Glycosylationi219 – 2191N-linked (GlcNAc...)PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Expressioni

    Developmental stagei

    Expressed in the vegetative cells. Increases during aggregation to mound stages (6-12 hours) and decreases at late developmental stages (18-24 hours).1 Publication

    Interactioni

    Protein-protein interaction databases

    STRINGi44689.DDB_0214993.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini22 – 10786Saposin B-typePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the countin family.Curated
    Contains 1 saposin B-type domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG12793.
    OMAiSGPHGTT.
    PhylomeDBiQ8WSR7.

    Family and domain databases

    InterProiIPR008139. SaposinB.
    [Graphical view]
    SMARTiSM00741. SapB. 1 hit.
    [Graphical view]
    PROSITEiPS50015. SAP_B. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8WSR7-1 [UniParc]FASTAAdd to Basket

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    MMIKYITIAI LFIASLVKAD LQFSLCPTCV DFINNDMGDL EKIISGGIAT    50
    SCGAVCSLLP NNIEQGACNL LCDIVGIDEF LKVFNNIGED ADPVWICEEL 100
    TVCPKNQNSN ATVLTSDVSP ASGPHGTTFT IGVAYKVEST LGTGEVAVMV 150
    TDPTGSNGFG DAQLIVNTQP GQYSTSFSFA ATPSEDEQFP AGVYQVQLMI 200
    CEGSCGAKHS VTFNSVYANF TVTSGPSVTG QMTGTGSGSG SGSGSSSGAA 250
    YLRY 254
    Length:254
    Mass (Da):26,347
    Last modified:March 1, 2002 - v1
    Checksum:i359482BE25C6D3AF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB067573 mRNA. Translation: BAB84187.1.
    AAFI02000033 Genomic DNA. Translation: EAL67512.1.
    RefSeqiXP_641512.1. XM_636420.1.

    Genome annotation databases

    EnsemblProtistsiDDB0214993; DDB0214993; DDB_G0279797.
    GeneIDi8622253.
    KEGGiddi:DDB_G0279797.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB067573 mRNA. Translation: BAB84187.1 .
    AAFI02000033 Genomic DNA. Translation: EAL67512.1 .
    RefSeqi XP_641512.1. XM_636420.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 44689.DDB_0214993.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0214993 ; DDB0214993 ; DDB_G0279797 .
    GeneIDi 8622253.
    KEGGi ddi:DDB_G0279797.

    Organism-specific databases

    dictyBasei DDB_G0279797. ctnB.

    Phylogenomic databases

    eggNOGi NOG12793.
    OMAi SGPHGTT.
    PhylomeDBi Q8WSR7.

    Family and domain databases

    InterProi IPR008139. SaposinB.
    [Graphical view ]
    SMARTi SM00741. SapB. 1 hit.
    [Graphical view ]
    PROSITEi PS50015. SAP_B. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Two cell-counting factors regulate the aggregate size of the cellular slime mold Dictyostelium discoideum."
      Okuwa T., Katayama T., Takano A., Kodaira K., Yasukawa H.
      Dev. Growth Differ. 43:735-744(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE.
    2. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.

    Entry informationi

    Entry nameiCTNB_DICDI
    AccessioniPrimary (citable) accession number: Q8WSR7
    Secondary accession number(s): Q54W80
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3