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Q8WSR7

- CTNB_DICDI

UniProt

Q8WSR7 - CTNB_DICDI

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Protein
Countin-2
Gene
ctnB, DDB_G0279797
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Cell-counting factor that limits the minimum size of the multicellular structure. May up-regulate the expression of both gp24 and gp80, which mediate cell adhesion.1 Publication

GO - Biological processi

  1. aggregation involved in sorocarp development Source: dictyBase
  2. single organismal cell-cell adhesion Source: dictyBase
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Countin-2
Gene namesi
Name:ctnB
ORF Names:DDB_G0279797
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 3, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0279797. ctnB.

Subcellular locationi

Secreted 1 Publication

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Disruption phenotypei

Cells form a higher number of smaller aggregates.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed prediction
Add
BLAST
Chaini20 – 254235Countin-2
PRO_0000327909Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi26 ↔ 103 By similarity
Disulfide bondi29 ↔ 97 By similarity
Disulfide bondi56 ↔ 68 By similarity
Glycosylationi110 – 1101N-linked (GlcNAc...) Reviewed prediction
Glycosylationi219 – 2191N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Developmental stagei

Expressed in the vegetative cells. Increases during aggregation to mound stages (6-12 hours) and decreases at late developmental stages (18-24 hours).1 Publication

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB_0214993.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini22 – 10786Saposin B-type
Add
BLAST

Sequence similaritiesi

Belongs to the countin family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG12793.
OMAiSGPHGTT.
PhylomeDBiQ8WSR7.

Family and domain databases

InterProiIPR008139. SaposinB.
[Graphical view]
SMARTiSM00741. SapB. 1 hit.
[Graphical view]
PROSITEiPS50015. SAP_B. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8WSR7-1 [UniParc]FASTAAdd to Basket

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MMIKYITIAI LFIASLVKAD LQFSLCPTCV DFINNDMGDL EKIISGGIAT    50
SCGAVCSLLP NNIEQGACNL LCDIVGIDEF LKVFNNIGED ADPVWICEEL 100
TVCPKNQNSN ATVLTSDVSP ASGPHGTTFT IGVAYKVEST LGTGEVAVMV 150
TDPTGSNGFG DAQLIVNTQP GQYSTSFSFA ATPSEDEQFP AGVYQVQLMI 200
CEGSCGAKHS VTFNSVYANF TVTSGPSVTG QMTGTGSGSG SGSGSSSGAA 250
YLRY 254
Length:254
Mass (Da):26,347
Last modified:March 1, 2002 - v1
Checksum:i359482BE25C6D3AF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB067573 mRNA. Translation: BAB84187.1.
AAFI02000033 Genomic DNA. Translation: EAL67512.1.
RefSeqiXP_641512.1. XM_636420.1.

Genome annotation databases

EnsemblProtistsiDDB0214993; DDB0214993; DDB_G0279797.
GeneIDi8622253.
KEGGiddi:DDB_G0279797.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB067573 mRNA. Translation: BAB84187.1 .
AAFI02000033 Genomic DNA. Translation: EAL67512.1 .
RefSeqi XP_641512.1. XM_636420.1.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

STRINGi 44689.DDB_0214993.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0214993 ; DDB0214993 ; DDB_G0279797 .
GeneIDi 8622253.
KEGGi ddi:DDB_G0279797.

Organism-specific databases

dictyBasei DDB_G0279797. ctnB.

Phylogenomic databases

eggNOGi NOG12793.
OMAi SGPHGTT.
PhylomeDBi Q8WSR7.

Family and domain databases

InterProi IPR008139. SaposinB.
[Graphical view ]
SMARTi SM00741. SapB. 1 hit.
[Graphical view ]
PROSITEi PS50015. SAP_B. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Two cell-counting factors regulate the aggregate size of the cellular slime mold Dictyostelium discoideum."
    Okuwa T., Katayama T., Takano A., Kodaira K., Yasukawa H.
    Dev. Growth Differ. 43:735-744(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE.
  2. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiCTNB_DICDI
AccessioniPrimary (citable) accession number: Q8WSR7
Secondary accession number(s): Q54W80
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: March 1, 2002
Last modified: July 9, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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