Reviewed,
UniProtKB/Swiss-Prot Q8WSR7 (CTNB_DICDI)
Last modified
February 9, 2010.
Version 35.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Countin-2 | ||||
| Gene names |
| ||||
| Organism | Dictyostelium discoideum (Slime mold) [Complete proteome] | ||||
| Taxonomic identifier | 44689 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium |
Protein attributes
| Sequence length | 254 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Cell-counting factor that limits the minimum size of the multicellular structure. May up-regulate the expression of both gp24 and gp80, which mediate cell adhesion. Ref.1 |
| Subcellular location | |
| Developmental stage | Expressed in the vegetative cells. Increases during aggregation to mound stages (6-12 hours) and decreases at late developmental stages (18-24 hours). Ref.1 |
| Disruption phenotype | Cells form a higher number of smaller aggregates. Ref.1 |
| Sequence similarities | Belongs to the countin family. Contains 1 saposin B-type domain. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Secreted |
| Domain | Signal |
| PTM | Disulfide bond Glycoprotein |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | aggregation involved in sorocarp development Ref.1 Inferred from mutant phenotype. Source: dictyBase cell-cell adhesion Ref.1Inferred from mutant phenotype. Source: dictyBase |
| Cellular component | extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 19 | 19 | Potential | ||||||||
| Chain | 20 – 254 | 235 | Countin-2 | PRO_0000327909 | |||||||
Regions | |||||||||||
| Domain | 22 – 107 | 86 | Saposin B-type | ||||||||
Amino acid modifications | |||||||||||
| Glycosylation | 110 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 219 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Disulfide bond | 26 ↔ 103 | By similarity | |||||||||
| Disulfide bond | 29 ↔ 97 | By similarity | |||||||||
| Disulfide bond | 56 ↔ 68 | By similarity | |||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Two cell-counting factors regulate the aggregate size of the cellular slime mold Dictyostelium discoideum." Okuwa T., Katayama T., Takano A., Kodaira K., Yasukawa H. Dev. Growth Differ. 43:735-744(2001) [PubMed: 11737154] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE. |
| [2] | "The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. Kuspa A.Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AB067573 mRNA. Translation: BAB84187.1. AAFI02000033 Genomic DNA. Translation: EAL67512.1. |
| RefSeq | XP_641512.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 8622253. |
| KEGG | ddi:DDB_0214993. |
Organism-specific databases | |
| dictyBase | DDB_G0279797. ctnB. |
Phylogenomic databases | |
| HOGENOM | HBG077942. |
Family and domain databases | |
| InterPro | IPR008139. SaposinB. [Graphical view] |
| SMART | SM00741. SapB. 1 hit. [Graphical view] |
| PROSITE | PS50015. SAP_B. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | CTNB_DICDI | ||||||||
| Accession | Primary (citable) accession number: Q8WSR7 Secondary accession number(s): Q54W80 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
Relevant documents
| Dictyostelium discoideum Dictyostelium discoideum: entries, gene names and cross-references to dictyBase |
| SIMILARITY comments Index of protein domains and families |

Clusters with


