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Protein
Submitted name:

Soluble acetylcholine receptor

Gene
N/A
Organism
Aplysia californica (California sea hare)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei25MannoseCombined sources1
Metal bindingi42Magnesium 1Combined sources1
Binding sitei42Beta-D-mannose; via carbonyl oxygenCombined sources1
Binding sitei43MannoseCombined sources1
Metal bindingi88Magnesium 2Combined sources1
Binding sitei88Mannose; via carbonyl oxygenCombined sources1
Metal bindingi167Magnesium 3Combined sources1
Metal bindingi167Magnesium 4Combined sources1
Metal bindingi170Magnesium 4Combined sources1
Binding sitei179Beta-D-mannoseCombined sources1
Binding sitei197MannoseCombined sources1
Metal bindingi204Magnesium 2; via tele nitrogenCombined sources1
Binding sitei220Beta-D-mannoseCombined sources1

GO - Molecular functioni

Keywordsi

Molecular functionReceptorImported
LigandMagnesiumCombined sources, Metal-bindingCombined sources

Names & Taxonomyi

Protein namesi
Submitted name:
Soluble acetylcholine receptorImported
OrganismiAplysia californica (California sea hare)Imported
Taxonomic identifieri6500 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaHeterobranchiaEuthyneuraEuopisthobranchiaAplysiomorphaAplysioideaAplysiidaeAplysia

Subcellular locationi

GO - Cellular componenti

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1944497.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_500431661420 – 236Sequence analysisAdd BLAST217

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi91N-linked (GlcNAc...)Combined sources1
Disulfide bondi144 ↔ 157Combined sources
Disulfide bondi207 ↔ 208Combined sources

Interactioni

Protein-protein interaction databases

DIPiDIP-46103N.
MINTiMINT-7300724.

Chemistry databases

BindingDBiQ8WSF8.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BR7X-ray3.00A/B/C/D/E20-236[»]
2BR8X-ray2.40A/B/C/D/E20-236[»]
2BYNX-ray2.02A/B/C/D/E16-236[»]
2BYPX-ray2.07A/B/C/D/E18-225[»]
2BYQX-ray3.40A/B/C/D/E16-236[»]
2BYRX-ray2.45A/B/C/D/E/F/G/H/I/J18-236[»]
2BYSX-ray2.05A/B/C/D/E/F/G/H/I/J16-236[»]
2C9TX-ray2.25A/B/C/D/E/F/G/H/I/J20-236[»]
2PGZX-ray1.76A/B/C/D/E18-236[»]
2PH9X-ray2.88A/B/C/D/E18-236[»]
2UZ6X-ray2.40A/B/C/D/E/F/G/H/I/J20-236[»]
2W8FX-ray2.70A/B/C/D/E/F/G/H/I/J20-236[»]
2W8GX-ray2.60A/B/C/D/E20-236[»]
2WN9X-ray1.75A/B/C/D/E16-236[»]
2WNCX-ray2.20A/B/C/D/E16-236[»]
2WNJX-ray1.80A/B/C/D/E16-236[»]
2WNLX-ray2.70A/B/C/D/E/F/G/H/I/J16-236[»]
2WZYX-ray2.51A/B/C/D/E/F/G/H/I/J16-236[»]
2X00X-ray2.40A/B/C/E16-236[»]
D18-236[»]
2XNTX-ray3.21A/B/C/D/E/F/G/H/I/J1-236[»]
2XNUX-ray2.55A/B/C/D/E1-236[»]
2XNVX-ray2.44A/B/C/D/E/F/G/H/I/J1-236[»]
2XYSX-ray1.91A/B/C/D/E20-236[»]
2XYTX-ray2.05A/B/C/D/E/F/G/H/I/J20-236[»]
2XZ5X-ray2.80A/B/C/D/E20-236[»]
2XZ6X-ray3.14A/B/C/D/E/F/G/H/I/J20-236[»]
2Y54X-ray3.65A/B/C/D/E20-236[»]
2Y56X-ray3.59A/B/C/D/E20-236[»]
2Y57X-ray3.30A/B/C/D/E20-236[»]
2Y58X-ray3.25A/B/C/D/E20-236[»]
2Y7YX-ray1.90A/B/C/D/E20-236[»]
2YMDX-ray1.96A/B/C/D/E/F/G/H/I/J20-231[»]
2YMEX-ray2.40A/B/C/D/E/F/G/H/I/J20-224[»]
3C79X-ray2.48A/B/C/D/E18-236[»]
3C84X-ray1.94A/B/C/D/E18-236[»]
3GUAX-ray3.10A/B/C/D/E/F/G/H/I/J18-225[»]
3PEOX-ray2.10A/B/C/D/E/F/G/H/I/J18-236[»]
3PMZX-ray2.44A/B/C/D/E/F/G/H/I/J18-236[»]
3SH1X-ray2.90A/B/C/D/E/F/G/H/I/J18-236[»]
3SIOX-ray2.32A/B/C/D/E/F/G/H/I/J18-236[»]
3T4MX-ray3.00A/B/C/D/E/F/G/H/I/J18-236[»]
4AFTX-ray3.20A/B/C/D/E20-236[»]
4BFQX-ray2.40A/B/C/D/E20-236[»]
4BQTX-ray2.88A/B/C/D/E20-236[»]
4DBMX-ray2.30A/B/C/D/E18-236[»]
4EZ1X-ray2.49A/B/C/D/E18-236[»]
4FRRX-ray2.20A/B/C/D/E/F/G/H/I/J18-225[»]
4WV9X-ray2.00A/B/C/D/E18-224[»]
4XHEX-ray1.90A/B/C/D/E/F/G/H/I/J18-225[»]
4XK9X-ray2.20A/B/C/D/E/F/G/H/I/J18-236[»]
4ZJSX-ray2.23A/B/C/D/E154-236[»]
4ZK4X-ray1.90A/B/C/D/E154-236[»]
5AINX-ray2.30A/B/C/D/E20-231[»]
5BRXX-ray2.05A/B/C/D/E/F/G/H/I/J18-236[»]
5BW2X-ray2.27A/B/C/D/E18-236[»]
5CO5X-ray2.10A/B/D/G/I1-236[»]
5JMEX-ray2.34A/B/C/D/E18-236[»]
5KE4X-ray2.55A/B/C/D/E18-236[»]
5KZUX-ray2.30A/B/C/D/E18-236[»]
5LXBX-ray2.34A/B/C/D/E/F/G/H/I/J1-236[»]
5SYOX-ray2.00A/B/C/D/E154-236[»]
5TVCX-ray1.93A/B/C/D/E154-236[»]
ProteinModelPortaliQ8WSF8.
SMRiQ8WSF8.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8WSF8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 222Neur_chan_LBDInterPro annotationAdd BLAST188

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni153 – 156Mannose bindingCombined sources4

Keywords - Domaini

SignalSequence analysis

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiView protein in InterPro
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiView protein in Pfam
PF02931. Neur_chan_LBD. 1 hit.
SUPFAMiSSF63712. SSF63712. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8WSF8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVSVYLALL VACVGQAHSQ ANLMRLKSDL FNRSPMYPGP TKDDPLTVTL
60 70 80 90 100
GFTLQDIVKA DSSTNEVDLV YYEQQRWKLN SLMWDPNEYG NITDFRTSAA
110 120 130 140 150
DIWTPDITAY SSTRPVQVLS PQIAVVTHDG SVMFIPAQRL SFMCDPTGVD
160 170 180 190 200
SEEGATCAVK FGSWVYSGFE IDLKTDTDQV DLSSYYASSK YEILSATQTR
210 220 230
QVQHYSCCPE PYIDVNLVVK FRERRAGNGF FRNLFD
Length:236
Mass (Da):26,568
Last modified:March 1, 2002 - v1
Checksum:i6D0DE487C46707BE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF322877 mRNA. Translation: AAL37251.1.
RefSeqiNP_001191488.1. NM_001204559.1.
UniGeneiAcl.89.

Genome annotation databases

GeneIDi100533247.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ8WSF8_APLCA
AccessioniPrimary (citable) accession number: Q8WSF8
Entry historyiIntegrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: July 5, 2017
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources