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Protein
Submitted name:

Soluble acetylcholine receptor

Gene
N/A
Organism
Aplysia californica (California sea hare)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi167 – 1671Magnesium 1Combined sources
Metal bindingi167 – 1671Magnesium 2Combined sources
Metal bindingi170 – 1701Magnesium 2Combined sources
Metal bindingi210 – 2101Magnesium 1Combined sources

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Keywords - Ligandi

MagnesiumCombined sources, Metal-bindingCombined sources

Names & Taxonomyi

Protein namesi
Submitted name:
Soluble acetylcholine receptorImported
OrganismiAplysia californica (California sea hare)Imported
Taxonomic identifieri6500 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaHeterobranchiaEuthyneuraEuopisthobranchiaAplysiomorphaAplysioideaAplysiidaeAplysia

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL1944497.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Chaini20 – 236217Sequence analysisPRO_5004316614Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi91 – 911N-linked (GlcNAc...)Combined sourcesCAR_5005390077
Disulfide bondi144 ↔ 157Combined sources
Disulfide bondi207 ↔ 208Combined sources

Interactioni

Protein-protein interaction databases

DIPiDIP-46103N.
MINTiMINT-7300724.

Chemistry

BindingDBiQ8WSF8.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2BR7X-ray3.00A/B/C/D/E20-236[»]
2BR8X-ray2.40A/B/C/D/E20-236[»]
2BYNX-ray2.02A/B/C/D/E18-236[»]
2BYPX-ray2.07A/B/C/D/E18-225[»]
2BYQX-ray3.40A/B/C/D/E18-236[»]
2BYRX-ray2.45A/B/C/D/E/F/G/H/I/J18-236[»]
2BYSX-ray2.05A/B/C/D/E/F/G/H/I/J18-236[»]
2C9TX-ray2.25A/B/C/D/E/F/G/H/I/J20-236[»]
2PGZX-ray1.76A/B/C/D/E18-236[»]
2PH9X-ray2.88A/B/C/D/E18-236[»]
2UZ6X-ray2.40A/B/C/D/E/F/G/H/I/J20-236[»]
2W8FX-ray2.70A/B/C/D/E/F/G/H/I/J20-236[»]
2W8GX-ray2.60A/B/C/D/E20-236[»]
2WN9X-ray1.75A/B/C/D/E18-236[»]
2WNCX-ray2.20A/B/C/D/E18-236[»]
2WNJX-ray1.80A/B/C/D/E18-236[»]
2WNLX-ray2.70A/B/C/D/E/F/G/H/I/J18-236[»]
2WZYX-ray2.51A/B/C/D/E/F/G/H/I/J18-236[»]
2X00X-ray2.40A/B/C/D/E18-236[»]
2XNTX-ray3.21A/B/C/D/E/F/G/H/I/J1-236[»]
2XNUX-ray2.55A/B/C/D/E1-236[»]
2XNVX-ray2.44A/B/C/D/E/F/G/H/I/J1-236[»]
2XYSX-ray1.91A/B/C/D/E20-236[»]
2XYTX-ray2.05A/B/C/D/E/F/G/H/I/J20-236[»]
2XZ5X-ray2.80A/B/C/D/E20-236[»]
2XZ6X-ray3.14A/B/C/D/E/F/G/H/I/J20-236[»]
2Y54X-ray3.65A/B/C/D/E20-236[»]
2Y56X-ray3.59A/B/C/D/E20-236[»]
2Y57X-ray3.30A/B/C/D/E20-236[»]
2Y58X-ray3.25A/B/C/D/E20-236[»]
2Y7YX-ray1.90A/B/C/D/E20-236[»]
2YMDX-ray1.96A/B/C/D/E/F/G/H/I/J20-231[»]
2YMEX-ray2.40A/B/C/D/E/F/G/H/I/J20-224[»]
3C79X-ray2.48A/B/C/D/E18-236[»]
3C84X-ray1.94A/B/C/D/E18-236[»]
3GUAX-ray3.10A/B/C/D/E/F/G/H/I/J18-225[»]
3PEOX-ray2.10A/B/C/D/E/F/G/H/I/J18-236[»]
3PMZX-ray2.44A/B/C/D/E/F/G/H/I/J18-236[»]
3SH1X-ray2.90A/B/C/D/E/F/G/H/I/J18-236[»]
3SIOX-ray2.32A/B/C/D/E/F/G/H/I/J18-236[»]
3T4MX-ray3.00A/B/C/D/E/F/G/H/I/J18-236[»]
4AFTX-ray3.20A/B/C/D/E20-236[»]
4BFQX-ray2.40A/B/C/D/E20-236[»]
4BQTX-ray2.88A/B/C/D/E20-236[»]
4DBMX-ray2.30A/B/C/D/E18-236[»]
4EZ1X-ray2.49A/B/C/D/E18-236[»]
4FRRX-ray2.20A/B/C/D/E/F/G/H/I/J18-225[»]
4WV9X-ray2.00A/B/C/D/E18-224[»]
4XHEX-ray1.90A/B/C/D/E/F/G/H/I/J18-225[»]
4XK9X-ray2.20A/B/C/D/E/F/G/H/I/J18-236[»]
4ZJSX-ray2.23A/B/C/D/E48-77[»]
A/B/C/D/E99-236[»]
4ZK4X-ray1.90A/B/C/D/E18-198[»]
A/B/C/D/E215-236[»]
5AINX-ray2.30A/B/C/D/E20-231[»]
5BRXX-ray2.05A/B/C/D/E/F/G/H/I/J18-236[»]
5BW2X-ray2.27A/B/C/D/E18-236[»]
5JMEX-ray2.34A/B/C/D/E18-236[»]
ProteinModelPortaliQ8WSF8.
SMRiQ8WSF8. Positions 18-226.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8WSF8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 222188Neur_chan_LBDInterPro annotationAdd
BLAST

Keywords - Domaini

SignalSequence analysis

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
[Graphical view]
SUPFAMiSSF63712. SSF63712. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8WSF8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVSVYLALL VACVGQAHSQ ANLMRLKSDL FNRSPMYPGP TKDDPLTVTL
60 70 80 90 100
GFTLQDIVKA DSSTNEVDLV YYEQQRWKLN SLMWDPNEYG NITDFRTSAA
110 120 130 140 150
DIWTPDITAY SSTRPVQVLS PQIAVVTHDG SVMFIPAQRL SFMCDPTGVD
160 170 180 190 200
SEEGATCAVK FGSWVYSGFE IDLKTDTDQV DLSSYYASSK YEILSATQTR
210 220 230
QVQHYSCCPE PYIDVNLVVK FRERRAGNGF FRNLFD
Length:236
Mass (Da):26,568
Last modified:March 1, 2002 - v1
Checksum:i6D0DE487C46707BE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF322877 mRNA. Translation: AAL37251.1.
RefSeqiNP_001191488.1. NM_001204559.1.
UniGeneiAcl.89.

Genome annotation databases

GeneIDi100533247.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF322877 mRNA. Translation: AAL37251.1.
RefSeqiNP_001191488.1. NM_001204559.1.
UniGeneiAcl.89.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2BR7X-ray3.00A/B/C/D/E20-236[»]
2BR8X-ray2.40A/B/C/D/E20-236[»]
2BYNX-ray2.02A/B/C/D/E18-236[»]
2BYPX-ray2.07A/B/C/D/E18-225[»]
2BYQX-ray3.40A/B/C/D/E18-236[»]
2BYRX-ray2.45A/B/C/D/E/F/G/H/I/J18-236[»]
2BYSX-ray2.05A/B/C/D/E/F/G/H/I/J18-236[»]
2C9TX-ray2.25A/B/C/D/E/F/G/H/I/J20-236[»]
2PGZX-ray1.76A/B/C/D/E18-236[»]
2PH9X-ray2.88A/B/C/D/E18-236[»]
2UZ6X-ray2.40A/B/C/D/E/F/G/H/I/J20-236[»]
2W8FX-ray2.70A/B/C/D/E/F/G/H/I/J20-236[»]
2W8GX-ray2.60A/B/C/D/E20-236[»]
2WN9X-ray1.75A/B/C/D/E18-236[»]
2WNCX-ray2.20A/B/C/D/E18-236[»]
2WNJX-ray1.80A/B/C/D/E18-236[»]
2WNLX-ray2.70A/B/C/D/E/F/G/H/I/J18-236[»]
2WZYX-ray2.51A/B/C/D/E/F/G/H/I/J18-236[»]
2X00X-ray2.40A/B/C/D/E18-236[»]
2XNTX-ray3.21A/B/C/D/E/F/G/H/I/J1-236[»]
2XNUX-ray2.55A/B/C/D/E1-236[»]
2XNVX-ray2.44A/B/C/D/E/F/G/H/I/J1-236[»]
2XYSX-ray1.91A/B/C/D/E20-236[»]
2XYTX-ray2.05A/B/C/D/E/F/G/H/I/J20-236[»]
2XZ5X-ray2.80A/B/C/D/E20-236[»]
2XZ6X-ray3.14A/B/C/D/E/F/G/H/I/J20-236[»]
2Y54X-ray3.65A/B/C/D/E20-236[»]
2Y56X-ray3.59A/B/C/D/E20-236[»]
2Y57X-ray3.30A/B/C/D/E20-236[»]
2Y58X-ray3.25A/B/C/D/E20-236[»]
2Y7YX-ray1.90A/B/C/D/E20-236[»]
2YMDX-ray1.96A/B/C/D/E/F/G/H/I/J20-231[»]
2YMEX-ray2.40A/B/C/D/E/F/G/H/I/J20-224[»]
3C79X-ray2.48A/B/C/D/E18-236[»]
3C84X-ray1.94A/B/C/D/E18-236[»]
3GUAX-ray3.10A/B/C/D/E/F/G/H/I/J18-225[»]
3PEOX-ray2.10A/B/C/D/E/F/G/H/I/J18-236[»]
3PMZX-ray2.44A/B/C/D/E/F/G/H/I/J18-236[»]
3SH1X-ray2.90A/B/C/D/E/F/G/H/I/J18-236[»]
3SIOX-ray2.32A/B/C/D/E/F/G/H/I/J18-236[»]
3T4MX-ray3.00A/B/C/D/E/F/G/H/I/J18-236[»]
4AFTX-ray3.20A/B/C/D/E20-236[»]
4BFQX-ray2.40A/B/C/D/E20-236[»]
4BQTX-ray2.88A/B/C/D/E20-236[»]
4DBMX-ray2.30A/B/C/D/E18-236[»]
4EZ1X-ray2.49A/B/C/D/E18-236[»]
4FRRX-ray2.20A/B/C/D/E/F/G/H/I/J18-225[»]
4WV9X-ray2.00A/B/C/D/E18-224[»]
4XHEX-ray1.90A/B/C/D/E/F/G/H/I/J18-225[»]
4XK9X-ray2.20A/B/C/D/E/F/G/H/I/J18-236[»]
4ZJSX-ray2.23A/B/C/D/E48-77[»]
A/B/C/D/E99-236[»]
4ZK4X-ray1.90A/B/C/D/E18-198[»]
A/B/C/D/E215-236[»]
5AINX-ray2.30A/B/C/D/E20-231[»]
5BRXX-ray2.05A/B/C/D/E/F/G/H/I/J18-236[»]
5BW2X-ray2.27A/B/C/D/E18-236[»]
5JMEX-ray2.34A/B/C/D/E18-236[»]
ProteinModelPortaliQ8WSF8.
SMRiQ8WSF8. Positions 18-226.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-46103N.
MINTiMINT-7300724.

Chemistry

BindingDBiQ8WSF8.
ChEMBLiCHEMBL1944497.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100533247.

Miscellaneous databases

EvolutionaryTraceiQ8WSF8.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
[Graphical view]
SUPFAMiSSF63712. SSF63712. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ8WSF8_APLCA
AccessioniPrimary (citable) accession number: Q8WSF8
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: July 6, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.