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Protein
Submitted name:

Soluble acetylcholine receptor

Gene
N/A
Organism
Aplysia californica (California sea hare)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi167 – 1671Magnesium 1
Metal bindingi167 – 1671Magnesium 2
Metal bindingi170 – 1701Magnesium 2
Metal bindingi210 – 2101Magnesium 1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Keywords - Ligandi

MagnesiumCombined sources, Metal-bindingCombined sources

Names & Taxonomyi

Protein namesi
Submitted name:
Soluble acetylcholine receptorImported
OrganismiAplysia californica (California sea hare)Imported
Taxonomic identifieri6500 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaHeterobranchiaEuthyneuraEuopisthobranchiaAplysiomorphaAplysioideaAplysiidaeAplysia

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi91 – 911N-linked (GlcNAc...)Combined sources
Disulfide bondi144 ↔ 157Combined sources
Disulfide bondi207 ↔ 208Combined sources

Interactioni

Protein-protein interaction databases

DIPiDIP-46103N.
MINTiMINT-7300724.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2BR7X-ray3.00A/B/C/D/E20-236[»]
2BR8X-ray2.40A/B/C/D/E20-236[»]
2BYNX-ray2.02A/B/C/D/E18-236[»]
2BYPX-ray2.07A/B/C/D/E18-225[»]
2BYQX-ray3.40A/B/C/D/E18-236[»]
2BYRX-ray2.45A/B/C/D/E/F/G/H/I/J18-236[»]
2BYSX-ray2.05A/B/C/D/E/F/G/H/I/J18-236[»]
2C9TX-ray2.25A/B/C/D/E/F/G/H/I/J20-236[»]
2PGZX-ray1.76A/B/C/D/E18-236[»]
2PH9X-ray2.88A/B/C/D/E18-236[»]
2UZ6X-ray2.40A/B/C/D/E/F/G/H/I/J20-236[»]
2W8FX-ray2.70A/B/C/D/E/F/G/H/I/J20-236[»]
2W8GX-ray2.60A/B/C/D/E20-236[»]
2WN9X-ray1.75A/B/C/D/E18-236[»]
2WNCX-ray2.20A/B/C/D/E18-236[»]
2WNJX-ray1.80A/B/C/D/E18-236[»]
2WNLX-ray2.70A/B/C/D/E/F/G/H/I/J18-236[»]
2WZYX-ray2.51A/B/C/D/E/F/G/H/I/J18-236[»]
2X00X-ray2.40A/B/C/D/E18-236[»]
2XNTX-ray3.21A/B/C/D/E/F/G/H/I/J1-236[»]
2XNUX-ray2.55A/B/C/D/E1-236[»]
2XNVX-ray2.44A/B/C/D/E/F/G/H/I/J1-236[»]
2XYSX-ray1.91A/B/C/D/E20-236[»]
2XYTX-ray2.05A/B/C/D/E/F/G/H/I/J20-236[»]
2XZ5X-ray2.80A/B/C/D/E20-236[»]
2XZ6X-ray3.14A/B/C/D/E/F/G/H/I/J20-236[»]
2Y54X-ray3.65A/B/C/D/E20-236[»]
2Y56X-ray3.59A/B/C/D/E20-236[»]
2Y57X-ray3.30A/B/C/D/E20-236[»]
2Y58X-ray3.25A/B/C/D/E20-236[»]
2Y7YX-ray1.90A/B/C/D/E20-236[»]
2YMDX-ray1.96A/B/C/D/E/F/G/H/I/J20-231[»]
2YMEX-ray2.40A/B/C/D/E/F/G/H/I/J20-224[»]
3C79X-ray2.48A/B/C/D/E18-236[»]
3C84X-ray1.94A/B/C/D/E18-236[»]
3GUAX-ray3.10A/B/C/D/E/F/G/H/I/J18-225[»]
3PEOX-ray2.10A/B/C/D/E/F/G/H/I/J18-236[»]
3PMZX-ray2.44A/B/C/D/E/F/G/H/I/J18-236[»]
3SH1X-ray2.90A/B/C/D/E/F/G/H/I/J18-236[»]
3SIOX-ray2.32A/B/C/D/E/F/G/H/I/J18-236[»]
3T4MX-ray3.00A/B/C/D/E/F/G/H/I/J18-236[»]
4AFTX-ray3.20A/B/C/D/E20-236[»]
4BFQX-ray2.40A/B/C/D/E20-236[»]
4BQTX-ray2.88A/B/C/D/E20-236[»]
4DBMX-ray2.30A/B/C/D/E18-236[»]
4EZ1X-ray2.49A/B/C/D/E18-236[»]
4FRRX-ray2.20A/B/C/D/E/F/G/H/I/J18-225[»]
4WV9X-ray2.00A/B/C/D/E18-224[»]
4XHEX-ray1.90A/B/C/D/E/F/G/H/I/J18-225[»]
4XK9X-ray2.20A/B/C/D/E/F/G/H/I/J18-236[»]
4ZJSX-ray2.23A/B/C/D/E48-77[»]
A/B/C/D/E99-236[»]
4ZK4X-ray1.90A/B/C/D/E18-198[»]
A/B/C/D/E215-236[»]
5AINX-ray2.30A/B/C/D/E20-231[»]
ProteinModelPortaliQ8WSF8.
SMRiQ8WSF8. Positions 18-226.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8WSF8.

Family & Domainsi

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
[Graphical view]
SUPFAMiSSF63712. SSF63712. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8WSF8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVSVYLALL VACVGQAHSQ ANLMRLKSDL FNRSPMYPGP TKDDPLTVTL
60 70 80 90 100
GFTLQDIVKA DSSTNEVDLV YYEQQRWKLN SLMWDPNEYG NITDFRTSAA
110 120 130 140 150
DIWTPDITAY SSTRPVQVLS PQIAVVTHDG SVMFIPAQRL SFMCDPTGVD
160 170 180 190 200
SEEGATCAVK FGSWVYSGFE IDLKTDTDQV DLSSYYASSK YEILSATQTR
210 220 230
QVQHYSCCPE PYIDVNLVVK FRERRAGNGF FRNLFD
Length:236
Mass (Da):26,568
Last modified:March 1, 2002 - v1
Checksum:i6D0DE487C46707BE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF322877 mRNA. Translation: AAL37251.1.
RefSeqiNP_001191488.1. NM_001204559.1.
UniGeneiAcl.89.

Genome annotation databases

GeneIDi100533247.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF322877 mRNA. Translation: AAL37251.1.
RefSeqiNP_001191488.1. NM_001204559.1.
UniGeneiAcl.89.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2BR7X-ray3.00A/B/C/D/E20-236[»]
2BR8X-ray2.40A/B/C/D/E20-236[»]
2BYNX-ray2.02A/B/C/D/E18-236[»]
2BYPX-ray2.07A/B/C/D/E18-225[»]
2BYQX-ray3.40A/B/C/D/E18-236[»]
2BYRX-ray2.45A/B/C/D/E/F/G/H/I/J18-236[»]
2BYSX-ray2.05A/B/C/D/E/F/G/H/I/J18-236[»]
2C9TX-ray2.25A/B/C/D/E/F/G/H/I/J20-236[»]
2PGZX-ray1.76A/B/C/D/E18-236[»]
2PH9X-ray2.88A/B/C/D/E18-236[»]
2UZ6X-ray2.40A/B/C/D/E/F/G/H/I/J20-236[»]
2W8FX-ray2.70A/B/C/D/E/F/G/H/I/J20-236[»]
2W8GX-ray2.60A/B/C/D/E20-236[»]
2WN9X-ray1.75A/B/C/D/E18-236[»]
2WNCX-ray2.20A/B/C/D/E18-236[»]
2WNJX-ray1.80A/B/C/D/E18-236[»]
2WNLX-ray2.70A/B/C/D/E/F/G/H/I/J18-236[»]
2WZYX-ray2.51A/B/C/D/E/F/G/H/I/J18-236[»]
2X00X-ray2.40A/B/C/D/E18-236[»]
2XNTX-ray3.21A/B/C/D/E/F/G/H/I/J1-236[»]
2XNUX-ray2.55A/B/C/D/E1-236[»]
2XNVX-ray2.44A/B/C/D/E/F/G/H/I/J1-236[»]
2XYSX-ray1.91A/B/C/D/E20-236[»]
2XYTX-ray2.05A/B/C/D/E/F/G/H/I/J20-236[»]
2XZ5X-ray2.80A/B/C/D/E20-236[»]
2XZ6X-ray3.14A/B/C/D/E/F/G/H/I/J20-236[»]
2Y54X-ray3.65A/B/C/D/E20-236[»]
2Y56X-ray3.59A/B/C/D/E20-236[»]
2Y57X-ray3.30A/B/C/D/E20-236[»]
2Y58X-ray3.25A/B/C/D/E20-236[»]
2Y7YX-ray1.90A/B/C/D/E20-236[»]
2YMDX-ray1.96A/B/C/D/E/F/G/H/I/J20-231[»]
2YMEX-ray2.40A/B/C/D/E/F/G/H/I/J20-224[»]
3C79X-ray2.48A/B/C/D/E18-236[»]
3C84X-ray1.94A/B/C/D/E18-236[»]
3GUAX-ray3.10A/B/C/D/E/F/G/H/I/J18-225[»]
3PEOX-ray2.10A/B/C/D/E/F/G/H/I/J18-236[»]
3PMZX-ray2.44A/B/C/D/E/F/G/H/I/J18-236[»]
3SH1X-ray2.90A/B/C/D/E/F/G/H/I/J18-236[»]
3SIOX-ray2.32A/B/C/D/E/F/G/H/I/J18-236[»]
3T4MX-ray3.00A/B/C/D/E/F/G/H/I/J18-236[»]
4AFTX-ray3.20A/B/C/D/E20-236[»]
4BFQX-ray2.40A/B/C/D/E20-236[»]
4BQTX-ray2.88A/B/C/D/E20-236[»]
4DBMX-ray2.30A/B/C/D/E18-236[»]
4EZ1X-ray2.49A/B/C/D/E18-236[»]
4FRRX-ray2.20A/B/C/D/E/F/G/H/I/J18-225[»]
4WV9X-ray2.00A/B/C/D/E18-224[»]
4XHEX-ray1.90A/B/C/D/E/F/G/H/I/J18-225[»]
4XK9X-ray2.20A/B/C/D/E/F/G/H/I/J18-236[»]
4ZJSX-ray2.23A/B/C/D/E48-77[»]
A/B/C/D/E99-236[»]
4ZK4X-ray1.90A/B/C/D/E18-198[»]
A/B/C/D/E215-236[»]
5AINX-ray2.30A/B/C/D/E20-231[»]
ProteinModelPortaliQ8WSF8.
SMRiQ8WSF8. Positions 18-226.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-46103N.
MINTiMINT-7300724.

Chemistry

BindingDBiQ8WSF8.
ChEMBLiCHEMBL1944497.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100533247.

Miscellaneous databases

EvolutionaryTraceiQ8WSF8.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
[Graphical view]
SUPFAMiSSF63712. SSF63712. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations."
    Hansen S.B., Sulzenbacher G., Huxford T., Marchot P., Taylor P., Bourne Y.
    EMBO J. 24:3635-3646(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.02 ANGSTROMS) OF 18-236, DISULFIDE BONDS, GLYCOSYLATION AT ASN-91.
  2. "Crystal structure of nicotinic acetylcholine receptor homolog AChBP in complex with an alpha-conotoxin PnIA variant."
    Celie P.H., Kasheverov I.E., Mordvintsev D.Y., Hogg R.C., van Nierop P., van Elk R., van Rossum-Fikkert S.E., Zhmak M.N., Bertrand D., Tsetlin V., Sixma T.K., Smit A.B.
    Nat. Struct. Mol. Biol. 12:582-588(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 20-236, DISULFIDE BONDS.
  3. Cited for: NUCLEOTIDE SEQUENCE.
  4. "Structural determinants of selective alpha-conotoxin binding to a nicotinic acetylcholine receptor homolog AChBP."
    Ulens C., Hogg R.C., Celie P.H., Bertrand D., Tsetlin V., Smit A.B., Sixma T.K.
    Proc. Natl. Acad. Sci. U.S.A. 103:3615-3620(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS) OF 20-236, DISULFIDE BONDS.
  5. "AChBP-targeted alpha-conotoxin correlates distinct binding orientations with nAChR subtype selectivity."
    Dutertre S., Ulens C., Buttner R., Fish A., van Elk R., Kendel Y., Hopping G., Alewood P.F., Schroeder C., Nicke A., Smit A.B., Sixma T.K., Lewis R.J.
    EMBO J. 26:3858-3867(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 20-236, DISULFIDE BONDS.
  6. "Galanthamine and non-competitive inhibitor binding to ACh-binding protein: evidence for a binding site on non-alpha-subunit interfaces of heteromeric neuronal nicotinic receptors."
    Hansen S.B., Taylor P.
    J. Mol. Biol. 369:895-901(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.76 ANGSTROMS) OF 18-236, DISULFIDE BONDS, GLYCOSYLATION AT ASN-91.
  7. "An ion selectivity filter in the extracellular domain of Cys-loop receptors reveals determinants for ion conductance."
    Hansen S.B., Wang H.L., Taylor P., Sine S.M.
    J. Biol. Chem. 283:36066-36070(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.10 ANGSTROMS) OF 18-225, DISULFIDE BONDS.
  8. "Atomic interactions of neonicotinoid agonists with AChBP: molecular recognition of the distinctive electronegative pharmacophore."
    Talley T.T., Harel M., Hibbs R.E., Radic Z., Tomizawa M., Casida J.E., Taylor P.
    Proc. Natl. Acad. Sci. U.S.A. 105:7606-7611(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.94 ANGSTROMS) OF 18-236, DISULFIDE BONDS.
  9. "Structural determinants for interaction of partial agonists with acetylcholine binding protein and neuronal alpha7 nicotinic acetylcholine receptor."
    Hibbs R.E., Sulzenbacher G., Shi J., Talley T.T., Conrod S., Kem W.R., Taylor P., Marchot P., Bourne Y.
    EMBO J. 28:3040-3051(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) OF 18-236, DISULFIDE BONDS, GLYCOSYLATION AT ASN-91.
  10. "Use of acetylcholine binding protein in the search for novel alpha7 nicotinic receptor ligands. In silico docking, pharmacological screening, and X-ray analysis."
    Ulens C., Akdemir A., Jongejan A., van Elk R., Bertrand S., Perrakis A., Leurs R., Smit A.B., Sixma T.K., Bertrand D., de Esch I.J.
    J. Med. Chem. 52:2372-2383(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF 20-236, DISULFIDE BONDS.
  11. "Main immunogenic region structure promotes binding of conformation-dependent myasthenia gravis autoantibodies, nicotinic acetylcholine receptor conformation maturation, and agonist sensitivity."
    Luo J., Taylor P., Losen M., de Baets M.H., Shelton G.D., Lindstrom J.
    J. Neurosci. 29:13898-13908(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.23 ANGSTROMS) OF 48-77 AND 99-236, DISULFIDE BONDS.
  12. "Structural determinants in phycotoxins and AChBP conferring high affinity binding and nicotinic AChR antagonism."
    Bourne Y., Radic Z., Araoz R., Talley T.T., Benoit E., Servent D., Taylor P., Molgo J., Marchot P.
    Proc. Natl. Acad. Sci. U.S.A. 107:6076-6081(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 18-236, DISULFIDE BONDS.
  13. "The curare alkaloids: analyzing the poses of complexes with the acetylcholine binding protein in relation to structure and binding energetics."
    Talley T.T., Harel M., Yamauchi G.J., Radic Z., Hansen S., Huxford T., Taylor P.W.
    Submitted (OCT-2010) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) OF 18-236, DISULFIDE BONDS.
  14. "The Curare Alkaloids: Analyzing the Poses of Complexes with the Acetylcholine Binding Protein in Relation to Structure and Binding Energies."
    Talley T.T., Harel M., Yamauchi J.G., Radic Z., Hansen S., Huxford T., Taylor P.W.
    Submitted (NOV-2010) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.44 ANGSTROMS) OF 18-236 IN COMPLEX WITH MAGNESIUM, DISULFIDE BONDS.
  15. "Acetylcholine binding protein (AChBP) as template for hierarchical in silico screening procedures to identify structurally novel ligands for the nicotinic receptors."
    Akdemir A., Rucktooa P., Jongejan A., Elk R.v., Bertrand S., Sixma T.K., Bertrand D., Smit A.B., Leurs R., de Graaf C., de Esch I.J.
    Bioorg. Med. Chem. 19:6107-6119(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.44 ANGSTROMS), DISULFIDE BONDS.
  16. "Fragment growing induces conformational changes in acetylcholine-binding protein: a structural and thermodynamic analysis."
    Edink E., Rucktooa P., Retra K., Akdemir A., Nahar T., Zuiderveld O., van Elk R., Janssen E., van Nierop P., van Muijlwijk-Koezen J., Smit A.B., Sixma T.K., Leurs R., de Esch I.J.
    J. Am. Chem. Soc. 133:5363-5371(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.25 ANGSTROMS) OF 20-236, DISULFIDE BONDS.
  17. "Crystal structures of a cysteine-modified mutant in loop D of acetylcholine-binding protein."
    Brams M., Gay E.A., Saez J.C., Guskov A., van Elk R., van der Schors R.C., Peigneur S., Tytgat J., Strelkov S.V., Smit A.B., Yakel J.L., Ulens C.
    J. Biol. Chem. 286:4420-4428(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.80 ANGSTROMS) OF 20-236, DISULFIDE BONDS.
  18. "Creating an alpha7 nicotinic acetylcholine recognition domain from the acetylcholine-binding protein: crystallographic and ligand selectivity analyses."
    Nemecz A., Taylor P.
    J. Biol. Chem. 286:42555-42565(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.32 ANGSTROMS) OF 18-236, DISULFIDE BONDS, GLYCOSYLATION AT ASN-91.
  19. "A structural and mutagenic blueprint for molecular recognition of strychnine and d-tubocurarine by different cys-loop receptors."
    Brams M., Pandya A., Kuzmin D., van Elk R., Krijnen L., Yakel J.L., Tsetlin V., Smit A.B., Ulens C.
    PLoS Biol. 9:e1001034-e1001034(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.91 ANGSTROMS) OF 20-236, DISULFIDE BONDS.
  20. "Generation of candidate ligands for nicotinic acetylcholine receptors via in situ click chemistry with a soluble acetylcholine binding protein template."
    Grimster N.P., Stump B., Fotsing J.R., Weide T., Talley T.T., Yamauchi J.G., Nemecz A., Kim C., Ho K.Y., Sharpless K.B., Taylor P., Fokin V.V.
    J. Am. Chem. Soc. 134:6732-6740(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 18-236, DISULFIDE BONDS, GLYCOSYLATION AT ASN-91.
  21. "Structural characterization of binding mode of smoking cessation drugs to nicotinic acetylcholine receptors through study of ligand complexes with acetylcholine-binding protein."
    Rucktooa P., Haseler C.A., van Elk R., Smit A.B., Gallagher T., Sixma T.K.
    J. Biol. Chem. 287:23283-23293(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.88 ANGSTROMS) OF 20-236, DISULFIDE BONDS.
  22. "Pairwise interaction of alpha-conotoxin BuIA Pro6 with the beta subunit of nicotinic acetylcholine receptor."
    Filchakova O.M., Talley T.T., Reger A.S., Kim C., Ho K., Han K., Taylor P., McIntosh J.M.
    Submitted (MAY-2012) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.49 ANGSTROMS) OF 18-236, DISULFIDE BONDS.
  23. "X-ray structure of Acetylcholine binding protein from Aplysia californica in presence of 3-((S)-azetidin-2-ylmethoxy)-5-((1S,2R)-2-(2-methoxyethyl)cyclopropyl)pyridine."
    Mukhopadhyay S., Mesecar A.D.
    Submitted (JUN-2012) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) OF 18-225, DISULFIDE BONDS.
  24. Cited for: X-RAY CRYSTALLOGRAPHY (1.96 ANGSTROMS) OF 20-231, DISULFIDE BONDS, GLYCOSYLATION AT ASN-91.
  25. "Assembly of a pi-pi stack of ligands in the binding site of an acetylcholine-binding protein."
    Stornaiuolo M., De Kloe G.E., Rucktooa P., Fish A., van Elk R., Edink E.S., Bertrand D., Smit A.B., de Esch I.J., Sixma T.K.
    Nat. Commun. 4:1875-1875(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 20-236, DISULFIDE BONDS.
  26. "Crystal structure of acetylcholine binding protein (AChBP) from Aplysia Californica in complex with click chemistry compound."
    Talley T.T.
    Submitted (NOV-2014) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 18-224, DISULFIDE BONDS.
  27. "Marine Macrocyclic Imines, Pinnatoxins A and G: Structural Determinants and Functional Properties to Distinguish Neuronal alpha7 from Muscle alpha12betagammadelta nAChRs."
    Bourne Y., Sulzenbacher G., Radic Z., Araoz R., Reynaud M., Benoit E., Zakarian A., Servent D., Molgo J., Taylor P., Marchot P.
    Structure 23:1106-1115(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF 18-225, DISULFIDE BONDS.
  28. "Varenicline Interactions at the 5-Ht3 Receptor Ligand Binding Site are Revealed by 5-Htbp."
    Price K.L., Lillestol R., Ulens C., Lummis S.C.
    Submitted (FEB-2015) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 20-231, DISULFIDE BONDS.
  29. "Crystal structure of a chimeric acetylcholine binding protein from Aplysia californica (Ac-AChBP) containing loop C from the human alpha 3 nicotinic acetylcholine receptor in complex with 7-(5-isopropoxy-pyridin-3-yl)-1-methyl-1,7-diaza-spiro[4.4]nonane."
    Bobango J., Wu J., Talley T.T.
    Submitted (APR-2015) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF 18-198 AND 215-236, DISULFIDE BONDS.

Entry informationi

Entry nameiQ8WSF8_APLCA
AccessioniPrimary (citable) accession number: Q8WSF8
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: July 22, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.