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Protein

Probable beta-hexosaminidase fdl

Gene

fdl

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in brain restructurization via hormonal control during metamorphosis. Implicated in N-glycan processing.2 Publications

Catalytic activityi

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.By similarity

GO - Molecular functioni

GO - Biological processi

  • brain development Source: UniProtKB
  • carbohydrate metabolic process Source: InterPro
  • N-glycan processing Source: FlyBase
  • protein deglycosylation Source: FlyBase
  • rhodopsin biosynthetic process Source: FlyBase

Keywordsi

Molecular functionDevelopmental protein, Glycosidase, Hydrolase

Enzyme and pathway databases

ReactomeiR-DME-1660662 Glycosphingolipid metabolism
R-DME-2022857 Keratan sulfate degradation
R-DME-2024101 CS/DS degradation
R-DME-2160916 Hyaluronan uptake and degradation
R-DME-6798695 Neutrophil degranulation

Protein family/group databases

CAZyiGH20 Glycoside Hydrolase Family 20

Names & Taxonomyi

Protein namesi
Recommended name:
Probable beta-hexosaminidase fdl (EC:3.2.1.52)
Alternative name(s):
Protein fused lobes
Gene namesi
Name:fdl
ORF Names:CG8824
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0045063 fdl

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 36Sequence analysisAdd BLAST36
ChainiPRO_000001201737 – 660Probable beta-hexosaminidase fdlAdd BLAST624

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi210N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi412N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi452N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8WSF3
PRIDEiQ8WSF3

Expressioni

Tissue specificityi

In third instar larval and early pupal brains, expressed in cells sending projections across the interhemispheric junction. In adult brain, expressed in mushroom body, ellipsoid body and pars intercerebralis.1 Publication

Gene expression databases

BgeeiFBgn0045063
ExpressionAtlasiQ8WSF3 differential
GenevisibleiQ8WSF3 DM

Interactioni

Protein-protein interaction databases

BioGridi75345, 4 interactors
DIPiDIP-21467N
IntActiQ8WSF3, 2 interactors
STRINGi7227.FBpp0087058

Structurei

3D structure databases

ProteinModelPortaliQ8WSF3
SMRiQ8WSF3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 20 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2499 Eukaryota
COG3525 LUCA
GeneTreeiENSGT00390000008107
InParanoidiQ8WSF3
KOiK20730
OMAiQIQRLDY
OrthoDBiEOG091G03S6
PhylomeDBiQ8WSF3

Family and domain databases

InterProiView protein in InterPro
IPR025705 Beta_hexosaminidase_sua/sub
IPR015883 Glyco_hydro_20_cat
IPR017853 Glycoside_hydrolase_SF
IPR029018 Hex-like_dom2
IPR029019 HEX_eukaryotic_N
PfamiView protein in Pfam
PF00728 Glyco_hydro_20, 1 hit
PF14845 Glycohydro_20b2, 1 hit
PIRSFiPIRSF001093 B-hxosamndse_ab_euk_, 1 hit
PRINTSiPR00738 GLHYDRLASE20
SUPFAMiSSF51445 SSF51445, 1 hit
SSF55545 SSF55545, 2 hits

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform C (identifier: Q8WSF3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLAVSLRRA LLVLLTGAIF ILTVLYWNQG VTKAQAYNEA LERPHSHHDA
60 70 80 90 100
SGFPIPVEKS WTYKCENDRC MRVGHHGKSA KRVSFISCSM TCGDVNIWPH
110 120 130 140 150
PTQKFLLSSQ THSFSVEDVQ LHVDTAHREV RKQLQLAFDW FLKDLRLIQR
160 170 180 190 200
LDYVGSSSEP TVSESSSKSR HHADLEPAAT LFGATFGVKK AGDLTSVQVK
210 220 230 240 250
ISVLKSGDLN FSLDNDETYQ LSTQTEGHRL QVEIIANSYF GARHGLSTLQ
260 270 280 290 300
QLIWFDDEDH LLHTYANSKV KDAPKFRYRG LMLDTSRHFF SVESIKRTIV
310 320 330 340 350
GMGLAKMNRF HWHLTDAQSF PYISRYYPEL AVHGAYSESE TYSEQDVREV
360 370 380 390 400
AEFAKIYGVQ VIPEIDAPAH AGNGWDWGPK RGMGELAMCI NQQPWSFYCG
410 420 430 440 450
EPPCGQLNPK NNYTYLILQR IYEELLQHTG PTDFFHLGGD EVNLDCWAQY
460 470 480 490 500
FNDTDLRGLW CDFMLQAMAR LKLANNGVAP KHVAVWSSAL TNTKCLPNSQ
510 520 530 540 550
FTVQVWGGST WQENYDLLDN GYNVIFSHVD AWYLDCGFGS WRATGDAACA
560 570 580 590 600
PYRTWQNVYK HRPWERMRLD KKRKKQVLGG EVCMWTEQVD ENQLDNRLWP
610 620 630 640 650
RTAALAERLW TDPSDDHDMD IVPPDVFRRI SLFRNRLVEL GIRAEALFPK
660
YCAQNPGECI
Length:660
Mass (Da):75,486
Last modified:March 1, 2002 - v1
Checksum:i0F14B47C9A55CD74
GO
Isoform B (identifier: Q8WSF3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MRYVYESLRYLYKM

Note: No experimental confirmation available.
Show »
Length:673
Mass (Da):77,252
Checksum:i7A73275BB491AE7D
GO

Sequence cautioni

The sequence AAL28585 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti154V → G in AAM29423 (PubMed:12537569).Curated1
Sequence conflicti495C → R in AAM29423 (PubMed:12537569).Curated1
Sequence conflicti551P → Q in AAM29423 (PubMed:12537569).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0119111M → MRYVYESLRYLYKM in isoform B. Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF323977 mRNA Translation: AAL55992.1
AE013599 Genomic DNA Translation: AAM68691.2
AE013599 Genomic DNA Translation: AAM68692.1
AY113418 mRNA Translation: AAM29423.1
AY061037 mRNA Translation: AAL28585.1 Different initiation.
RefSeqiNP_001286350.1, NM_001299421.1 [Q8WSF3-1]
NP_725178.2, NM_165908.2 [Q8WSF3-2]
NP_725179.1, NM_165909.3 [Q8WSF3-1]
UniGeneiDm.3735

Genome annotation databases

EnsemblMetazoaiFBtr0087946; FBpp0087057; FBgn0045063 [Q8WSF3-1]
FBtr0087947; FBpp0087058; FBgn0045063 [Q8WSF3-2]
FBtr0346633; FBpp0312213; FBgn0045063 [Q8WSF3-1]
GeneIDi250735
KEGGidme:Dmel_CG8824

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiFDL_DROME
AccessioniPrimary (citable) accession number: Q8WSF3
Secondary accession number(s): Q8MZ16, Q95RY8, Q9V6C8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2003
Last sequence update: March 1, 2002
Last modified: March 28, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health