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Q8WSF3

- FDL_DROME

UniProt

Q8WSF3 - FDL_DROME

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Protein

Probable beta-hexosaminidase fdl

Gene
fdl, CG8824
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in brain restructurization via hormonal control during metamorphosis. Implicated in N-glycan processing.2 Publications

Catalytic activityi

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.By similarity

GO - Molecular functioni

  1. beta-N-acetylglucosaminidase activity Source: FlyBase
  2. beta-N-acetylhexosaminidase activity Source: UniProtKB

GO - Biological processi

  1. brain development Source: UniProtKB
  2. N-glycan processing Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH20. Glycoside Hydrolase Family 20.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable beta-hexosaminidase fdl (EC:3.2.1.52)
Alternative name(s):
Protein fused lobes
Gene namesi
Name:fdl
ORF Names:CG8824
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0045063. fdl.

Subcellular locationi

GO - Cellular componenti

  1. late endosome Source: FlyBase
  2. plasma membrane Source: FlyBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3636 Reviewed predictionAdd
BLAST
Chaini37 – 660624Probable beta-hexosaminidase fdlPRO_0000012017Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi210 – 2101N-linked (GlcNAc...) Reviewed prediction
Glycosylationi412 – 4121N-linked (GlcNAc...) Reviewed prediction
Glycosylationi452 – 4521N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8WSF3.
PRIDEiQ8WSF3.

Expressioni

Tissue specificityi

In third instar larval and early pupal brains, expressed in cells sending projections across the interhemispheric junction. In adult brain, expressed in mushroom body, ellipsoid body and pars intercerebralis.1 Publication

Gene expression databases

BgeeiQ8WSF3.

Interactioni

Protein-protein interaction databases

BioGridi75345. 4 interactions.
DIPiDIP-21467N.
MINTiMINT-1665363.
STRINGi7227.FBpp0087058.

Structurei

3D structure databases

ProteinModelPortaliQ8WSF3.
SMRiQ8WSF3. Positions 177-652.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG3525.
GeneTreeiENSGT00390000008107.
InParanoidiQ8WSF3.
KOiK12373.
OMAiVYKHRPW.
OrthoDBiEOG79W94H.
PhylomeDBiQ8WSF3.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
3.30.379.10. 1 hit.
InterProiIPR025705. Beta_hexosaminidase_sua/sub.
IPR029018. Chitobiase/Hex_dom_2-like.
IPR015883. Glyco_hydro_20_cat-core.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR029019. HEX_eukaryotic_N.
[Graphical view]
PfamiPF00728. Glyco_hydro_20. 1 hit.
PF14845. Glycohydro_20b2. 1 hit.
[Graphical view]
PIRSFiPIRSF001093. B-hxosamndse_ab_euk_. 1 hit.
PRINTSiPR00738. GLHYDRLASE20.
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF55545. SSF55545. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform C (identifier: Q8WSF3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSLAVSLRRA LLVLLTGAIF ILTVLYWNQG VTKAQAYNEA LERPHSHHDA    50
SGFPIPVEKS WTYKCENDRC MRVGHHGKSA KRVSFISCSM TCGDVNIWPH 100
PTQKFLLSSQ THSFSVEDVQ LHVDTAHREV RKQLQLAFDW FLKDLRLIQR 150
LDYVGSSSEP TVSESSSKSR HHADLEPAAT LFGATFGVKK AGDLTSVQVK 200
ISVLKSGDLN FSLDNDETYQ LSTQTEGHRL QVEIIANSYF GARHGLSTLQ 250
QLIWFDDEDH LLHTYANSKV KDAPKFRYRG LMLDTSRHFF SVESIKRTIV 300
GMGLAKMNRF HWHLTDAQSF PYISRYYPEL AVHGAYSESE TYSEQDVREV 350
AEFAKIYGVQ VIPEIDAPAH AGNGWDWGPK RGMGELAMCI NQQPWSFYCG 400
EPPCGQLNPK NNYTYLILQR IYEELLQHTG PTDFFHLGGD EVNLDCWAQY 450
FNDTDLRGLW CDFMLQAMAR LKLANNGVAP KHVAVWSSAL TNTKCLPNSQ 500
FTVQVWGGST WQENYDLLDN GYNVIFSHVD AWYLDCGFGS WRATGDAACA 550
PYRTWQNVYK HRPWERMRLD KKRKKQVLGG EVCMWTEQVD ENQLDNRLWP 600
RTAALAERLW TDPSDDHDMD IVPPDVFRRI SLFRNRLVEL GIRAEALFPK 650
YCAQNPGECI 660
Length:660
Mass (Da):75,486
Last modified:March 1, 2002 - v1
Checksum:i0F14B47C9A55CD74
GO
Isoform B (identifier: Q8WSF3-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MRYVYESLRYLYKM

Note: No experimental confirmation available.

Show »
Length:673
Mass (Da):77,252
Checksum:i7A73275BB491AE7D
GO

Sequence cautioni

The sequence AAL28585.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 11M → MRYVYESLRYLYKM in isoform B. VSP_011911

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti154 – 1541V → G in AAM29423. 1 Publication
Sequence conflicti495 – 4951C → R in AAM29423. 1 Publication
Sequence conflicti551 – 5511P → Q in AAM29423. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF323977 mRNA. Translation: AAL55992.1.
AE013599 Genomic DNA. Translation: AAM68691.2.
AE013599 Genomic DNA. Translation: AAM68692.1.
AY113418 mRNA. Translation: AAM29423.1.
AY061037 mRNA. Translation: AAL28585.1. Different initiation.
RefSeqiNP_725178.2. NM_165908.1. [Q8WSF3-2]
NP_725179.1. NM_165909.2. [Q8WSF3-1]
UniGeneiDm.3735.

Genome annotation databases

EnsemblMetazoaiFBtr0087946; FBpp0087057; FBgn0045063. [Q8WSF3-1]
GeneIDi250735.
KEGGidme:Dmel_CG8824.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF323977 mRNA. Translation: AAL55992.1 .
AE013599 Genomic DNA. Translation: AAM68691.2 .
AE013599 Genomic DNA. Translation: AAM68692.1 .
AY113418 mRNA. Translation: AAM29423.1 .
AY061037 mRNA. Translation: AAL28585.1 . Different initiation.
RefSeqi NP_725178.2. NM_165908.1. [Q8WSF3-2 ]
NP_725179.1. NM_165909.2. [Q8WSF3-1 ]
UniGenei Dm.3735.

3D structure databases

ProteinModelPortali Q8WSF3.
SMRi Q8WSF3. Positions 177-652.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 75345. 4 interactions.
DIPi DIP-21467N.
MINTi MINT-1665363.
STRINGi 7227.FBpp0087058.

Protein family/group databases

CAZyi GH20. Glycoside Hydrolase Family 20.

Proteomic databases

PaxDbi Q8WSF3.
PRIDEi Q8WSF3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0087946 ; FBpp0087057 ; FBgn0045063 . [Q8WSF3-1 ]
GeneIDi 250735.
KEGGi dme:Dmel_CG8824.

Organism-specific databases

CTDi 250735.
FlyBasei FBgn0045063. fdl.

Phylogenomic databases

eggNOGi COG3525.
GeneTreei ENSGT00390000008107.
InParanoidi Q8WSF3.
KOi K12373.
OMAi VYKHRPW.
OrthoDBi EOG79W94H.
PhylomeDBi Q8WSF3.

Miscellaneous databases

GenomeRNAii 250735.
NextBioi 843498.

Gene expression databases

Bgeei Q8WSF3.

Family and domain databases

Gene3Di 3.20.20.80. 1 hit.
3.30.379.10. 1 hit.
InterProi IPR025705. Beta_hexosaminidase_sua/sub.
IPR029018. Chitobiase/Hex_dom_2-like.
IPR015883. Glyco_hydro_20_cat-core.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR029019. HEX_eukaryotic_N.
[Graphical view ]
Pfami PF00728. Glyco_hydro_20. 1 hit.
PF14845. Glycohydro_20b2. 1 hit.
[Graphical view ]
PIRSFi PIRSF001093. B-hxosamndse_ab_euk_. 1 hit.
PRINTSi PR00738. GLHYDRLASE20.
SUPFAMi SSF51445. SSF51445. 1 hit.
SSF55545. SSF55545. 2 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Central brain postembryonic development in Drosophila: implication of genes expressed at the interhemispheric junction."
    Boquet I., Hitier R., Dumas M., Chaminade M., Preat T.
    J. Neurobiol. 42:33-48(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE (ISOFORM C), FUNCTION, TISSUE SPECIFICITY.
  2. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  3. Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
    Strain: Berkeley.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM C).
    Strain: Berkeley.
    Tissue: Embryo and Head.
  5. Leonard R., Altmann F.
    Submitted (APR-2003) to UniProtKB
    Cited for: FUNCTION IN N-GLYCAN PROCESSING.

Entry informationi

Entry nameiFDL_DROME
AccessioniPrimary (citable) accession number: Q8WSF3
Secondary accession number(s): Q8MZ16, Q95RY8, Q9V6C8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2003
Last sequence update: March 1, 2002
Last modified: July 9, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi