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Q8WS31

- Q8WS31_PLAFA

UniProt

Q8WS31 - Q8WS31_PLAFA

Protein
Submitted name:

Erythrocyte binding antigen 140

Gene
N/A
Organism
Plasmodium falciparum
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 36 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. receptor activity Source: InterPro

    GO - Biological processi

    1. pathogenesis Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Erythrocyte binding antigen 140Imported
    OrganismiPlasmodium falciparumImported
    Taxonomic identifieri5833 [NCBI]
    Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiumPlasmodium (Laverania)

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: InterPro

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4GF2X-ray2.40A141-755[»]
    4JNOX-ray3.00A141-755[»]
    ProteinModelPortaliQ8WS31.
    SMRiQ8WS31. Positions 143-740, 1049-1127.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Family and domain databases

    InterProiIPR008602. Duffy-antigen_binding.
    IPR021620. EBA-175_VI.
    [Graphical view]
    PfamiPF05424. Duffy_binding. 2 hits.
    PF11556. EBA-175_VI. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8WS31-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKGYFNIYFL IPLIFLYNVI RINESIIGRT LYNRQDESSD ISRVNSPELN     50
    NNHKTNIYDS DYEDVNNKLI NSFVENKSVK KKRSLSFINN KTKSYDIIPP 100
    SYSYRNDKFN SLSENEDNSG NTNSNNFANT SEISIGKDNK QYTFIQKRTH 150
    LFACGIKRKS IKWICRENSE KITVCVPDRK IQLCIANFLN SRLETMEKFK 200
    EIFLISVNTE AKLLYNKNEG KDPSIFCNEL RNSFSDFRNS FIGDDMDFGG 250
    NTDRVKGYIN KKFSDYYKEK NVEKLNNIKK EWWEKNKANL WNHMIVNHKG 300
    NISKECAIIP AEEPQINLWI KEWNENFLME KKRLFLNIKD KCVENKKYEA 350
    CFGGCRLPCS SYTSFMKKSK TQMEVLTNLY KKKNSGVDKN NFLNDLFKKN 400
    NKNDLDDFFK NEKEYDDLCD CRYTATIIKS FLNGPAKNDV DIASQINVND 450
    LRGFGCNYKS NNEKSWNCTG TFTNKFPGTC EPPRRQTLCL GRTYLLHRGH 500
    EEDYKEHLLG ASIYEAQLLK YKYKEKDENA LCSIIQNSYA DLADIIKGSD 550
    IIKDYYGKKM EENLNKVNKD KKRNEESLKI FREKWWDENK ENVWKVMSAV 600
    LKNKETCKDY DKFQKIPQFL RWFKEWGDDF CEKRKEKIYS FESFKVECKK 650
    KDCDENTCKN KCSEYKKWID LKKSEYEKQV DKYTKDKNKK MYDNIDEVKN 700
    KEANVYLKEK SKECKDVNFD DKIFNESPNE YEDMCKKCDE IKYLNEIKYP 750
    KTKHDIYDID TFSDTFGDGT PISINANINE QQSGKDTSNT GNSETSDSPV 800
    SHEPESDAAI NVEKLSGDES SSETRGILDI NDPSVTNNVN EVHDASNTQG 850
    SVSNTSDITN GHSESSLNRT TNAQDIKIGR SGNEQSDNQE NSSHSSDNSG 900
    SLTIGQVPSE DNTQNTYDSQ NPHRDTPNAL ASLPSDDKIN EIEGFDSSRD 950
    SENGRGDTTS NTHDVRRTNI VSERRVNSHD FIRNGMANNN AHHQYITQIE 1000
    NNGIIRGQEE SAGNSVNYKD NPKRSNFSSE NDHKKNIQEY NSRDTKRVRE 1050
    EIIKLSKQNK CNNEYSMEYC TYSDERNSSP GPCSREERKK LCCQISDYCL 1100
    KYFNFYSIEY YNCIKSEIKS PEYKCFKSEG QSSIPYFAAG GILVVIVLLL 1150
    SSASRMGKSN EEYDIGESNI EATFEENNYL NKLSRIFNQE VQETNISDYS 1200
    EYNYNEKNMY 1210
    Length:1,210
    Mass (Da):140,596
    Last modified:March 1, 2002 - v1
    Checksum:iFF44FBB8DA69D605
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF384554 Genomic DNA. Translation: AAL58319.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF384554 Genomic DNA. Translation: AAL58319.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4GF2 X-ray 2.40 A 141-755 [» ]
    4JNO X-ray 3.00 A 141-755 [» ]
    ProteinModelPortali Q8WS31.
    SMRi Q8WS31. Positions 143-740, 1049-1127.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR008602. Duffy-antigen_binding.
    IPR021620. EBA-175_VI.
    [Graphical view ]
    Pfami PF05424. Duffy_binding. 2 hits.
    PF11556. EBA-175_VI. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel ligand from Plasmodium falciparum that binds to a sialic acid-containing receptor on the surface of human erythrocytes."
      Thompson J.K., Triglia T., Reed M.B., Cowman A.F.
      Mol. Microbiol. 0:0-0(2002)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 3D7Imported.
    2. "Crystal and solution structures of Plasmodium falciparum erythrocyte-binding antigen 140 reveal determinants of receptor specificity during erythrocyte invasion."
      Lin D.H., Malpede B.M., Batchelor J.D., Tolia N.H.
      J. Biol. Chem. 287:36830-36836(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 141-755.
    3. "Molecular basis for sialic acid-dependent receptor recognition by the Plasmodium falciparum invasion protein erythrocyte-binding antigen-140/BAEBL."
      Malpede B.M., Lin D.H., Tolia N.H.
      J. Biol. Chem. 288:12406-12415(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.00 ANGSTROMS) OF 141-755.

    Entry informationi

    Entry nameiQ8WS31_PLAFA
    AccessioniPrimary (citable) accession number: Q8WS31
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 1, 2002
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 36 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3