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Q8WS31

- Q8WS31_PLAFA

UniProt

Q8WS31 - Q8WS31_PLAFA

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Protein
Submitted name:

Erythrocyte binding antigen 140

Gene
N/A
Organism
Plasmodium falciparum
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. receptor activity Source: InterPro

GO - Biological processi

  1. pathogenesis Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Erythrocyte binding antigen 140Imported
OrganismiPlasmodium falciparumImported
Taxonomic identifieri5833 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiumPlasmodium (Laverania)

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: InterPro
Complete GO annotation...

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4GF2X-ray2.40A141-755[»]
4JNOX-ray3.00A141-755[»]
ProteinModelPortaliQ8WS31.
SMRiQ8WS31. Positions 143-740, 1049-1127.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Family and domain databases

InterProiIPR008602. Duffy-antigen_binding.
IPR021620. EBA-175_VI.
[Graphical view]
PfamiPF05424. Duffy_binding. 2 hits.
PF11556. EBA-175_VI. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WS31-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKGYFNIYFL IPLIFLYNVI RINESIIGRT LYNRQDESSD ISRVNSPELN
60 70 80 90 100
NNHKTNIYDS DYEDVNNKLI NSFVENKSVK KKRSLSFINN KTKSYDIIPP
110 120 130 140 150
SYSYRNDKFN SLSENEDNSG NTNSNNFANT SEISIGKDNK QYTFIQKRTH
160 170 180 190 200
LFACGIKRKS IKWICRENSE KITVCVPDRK IQLCIANFLN SRLETMEKFK
210 220 230 240 250
EIFLISVNTE AKLLYNKNEG KDPSIFCNEL RNSFSDFRNS FIGDDMDFGG
260 270 280 290 300
NTDRVKGYIN KKFSDYYKEK NVEKLNNIKK EWWEKNKANL WNHMIVNHKG
310 320 330 340 350
NISKECAIIP AEEPQINLWI KEWNENFLME KKRLFLNIKD KCVENKKYEA
360 370 380 390 400
CFGGCRLPCS SYTSFMKKSK TQMEVLTNLY KKKNSGVDKN NFLNDLFKKN
410 420 430 440 450
NKNDLDDFFK NEKEYDDLCD CRYTATIIKS FLNGPAKNDV DIASQINVND
460 470 480 490 500
LRGFGCNYKS NNEKSWNCTG TFTNKFPGTC EPPRRQTLCL GRTYLLHRGH
510 520 530 540 550
EEDYKEHLLG ASIYEAQLLK YKYKEKDENA LCSIIQNSYA DLADIIKGSD
560 570 580 590 600
IIKDYYGKKM EENLNKVNKD KKRNEESLKI FREKWWDENK ENVWKVMSAV
610 620 630 640 650
LKNKETCKDY DKFQKIPQFL RWFKEWGDDF CEKRKEKIYS FESFKVECKK
660 670 680 690 700
KDCDENTCKN KCSEYKKWID LKKSEYEKQV DKYTKDKNKK MYDNIDEVKN
710 720 730 740 750
KEANVYLKEK SKECKDVNFD DKIFNESPNE YEDMCKKCDE IKYLNEIKYP
760 770 780 790 800
KTKHDIYDID TFSDTFGDGT PISINANINE QQSGKDTSNT GNSETSDSPV
810 820 830 840 850
SHEPESDAAI NVEKLSGDES SSETRGILDI NDPSVTNNVN EVHDASNTQG
860 870 880 890 900
SVSNTSDITN GHSESSLNRT TNAQDIKIGR SGNEQSDNQE NSSHSSDNSG
910 920 930 940 950
SLTIGQVPSE DNTQNTYDSQ NPHRDTPNAL ASLPSDDKIN EIEGFDSSRD
960 970 980 990 1000
SENGRGDTTS NTHDVRRTNI VSERRVNSHD FIRNGMANNN AHHQYITQIE
1010 1020 1030 1040 1050
NNGIIRGQEE SAGNSVNYKD NPKRSNFSSE NDHKKNIQEY NSRDTKRVRE
1060 1070 1080 1090 1100
EIIKLSKQNK CNNEYSMEYC TYSDERNSSP GPCSREERKK LCCQISDYCL
1110 1120 1130 1140 1150
KYFNFYSIEY YNCIKSEIKS PEYKCFKSEG QSSIPYFAAG GILVVIVLLL
1160 1170 1180 1190 1200
SSASRMGKSN EEYDIGESNI EATFEENNYL NKLSRIFNQE VQETNISDYS
1210
EYNYNEKNMY
Length:1,210
Mass (Da):140,596
Last modified:March 1, 2002 - v1
Checksum:iFF44FBB8DA69D605
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF384554 Genomic DNA. Translation: AAL58319.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF384554 Genomic DNA. Translation: AAL58319.1 .

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4GF2 X-ray 2.40 A 141-755 [» ]
4JNO X-ray 3.00 A 141-755 [» ]
ProteinModelPortali Q8WS31.
SMRi Q8WS31. Positions 143-740, 1049-1127.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR008602. Duffy-antigen_binding.
IPR021620. EBA-175_VI.
[Graphical view ]
Pfami PF05424. Duffy_binding. 2 hits.
PF11556. EBA-175_VI. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A novel ligand from Plasmodium falciparum that binds to a sialic acid-containing receptor on the surface of human erythrocytes."
    Thompson J.K., Triglia T., Reed M.B., Cowman A.F.
    Mol. Microbiol. 0:0-0(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 3D7Imported.
  2. "Crystal and solution structures of Plasmodium falciparum erythrocyte-binding antigen 140 reveal determinants of receptor specificity during erythrocyte invasion."
    Lin D.H., Malpede B.M., Batchelor J.D., Tolia N.H.
    J. Biol. Chem. 287:36830-36836(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 141-755, ACTIVE SITE.
  3. "Molecular basis for sialic acid-dependent receptor recognition by the Plasmodium falciparum invasion protein erythrocyte-binding antigen-140/BAEBL."
    Malpede B.M., Lin D.H., Tolia N.H.
    J. Biol. Chem. 288:12406-12415(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.00 ANGSTROMS) OF 141-755, ACTIVE SITE.

Entry informationi

Entry nameiQ8WS31_PLAFA
AccessioniPrimary (citable) accession number: Q8WS31
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: November 26, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3