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Q8WS31 (Q8WS31_PLAFA) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
OrganismPlasmodium falciparum EMBL AAL58319.1
Taxonomic identifier5833 [NCBI]
Taxonomic lineageEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiumPlasmodium (Laverania)

Protein attributes

Sequence length1210 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

Ontologies

Keywords
   Technical term3D-structure PDB 4GF2 PDB 4JNO
Gene Ontology (GO)
   Biological_processpathogenesis

Inferred from electronic annotation. Source: InterPro

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: InterPro

   Molecular_functionreceptor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q8WS31 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: FF44FBB8DA69D605

FASTA1,210140,596
        10         20         30         40         50         60 
MKGYFNIYFL IPLIFLYNVI RINESIIGRT LYNRQDESSD ISRVNSPELN NNHKTNIYDS 

        70         80         90        100        110        120 
DYEDVNNKLI NSFVENKSVK KKRSLSFINN KTKSYDIIPP SYSYRNDKFN SLSENEDNSG 

       130        140        150        160        170        180 
NTNSNNFANT SEISIGKDNK QYTFIQKRTH LFACGIKRKS IKWICRENSE KITVCVPDRK 

       190        200        210        220        230        240 
IQLCIANFLN SRLETMEKFK EIFLISVNTE AKLLYNKNEG KDPSIFCNEL RNSFSDFRNS 

       250        260        270        280        290        300 
FIGDDMDFGG NTDRVKGYIN KKFSDYYKEK NVEKLNNIKK EWWEKNKANL WNHMIVNHKG 

       310        320        330        340        350        360 
NISKECAIIP AEEPQINLWI KEWNENFLME KKRLFLNIKD KCVENKKYEA CFGGCRLPCS 

       370        380        390        400        410        420 
SYTSFMKKSK TQMEVLTNLY KKKNSGVDKN NFLNDLFKKN NKNDLDDFFK NEKEYDDLCD 

       430        440        450        460        470        480 
CRYTATIIKS FLNGPAKNDV DIASQINVND LRGFGCNYKS NNEKSWNCTG TFTNKFPGTC 

       490        500        510        520        530        540 
EPPRRQTLCL GRTYLLHRGH EEDYKEHLLG ASIYEAQLLK YKYKEKDENA LCSIIQNSYA 

       550        560        570        580        590        600 
DLADIIKGSD IIKDYYGKKM EENLNKVNKD KKRNEESLKI FREKWWDENK ENVWKVMSAV 

       610        620        630        640        650        660 
LKNKETCKDY DKFQKIPQFL RWFKEWGDDF CEKRKEKIYS FESFKVECKK KDCDENTCKN 

       670        680        690        700        710        720 
KCSEYKKWID LKKSEYEKQV DKYTKDKNKK MYDNIDEVKN KEANVYLKEK SKECKDVNFD 

       730        740        750        760        770        780 
DKIFNESPNE YEDMCKKCDE IKYLNEIKYP KTKHDIYDID TFSDTFGDGT PISINANINE 

       790        800        810        820        830        840 
QQSGKDTSNT GNSETSDSPV SHEPESDAAI NVEKLSGDES SSETRGILDI NDPSVTNNVN 

       850        860        870        880        890        900 
EVHDASNTQG SVSNTSDITN GHSESSLNRT TNAQDIKIGR SGNEQSDNQE NSSHSSDNSG 

       910        920        930        940        950        960 
SLTIGQVPSE DNTQNTYDSQ NPHRDTPNAL ASLPSDDKIN EIEGFDSSRD SENGRGDTTS 

       970        980        990       1000       1010       1020 
NTHDVRRTNI VSERRVNSHD FIRNGMANNN AHHQYITQIE NNGIIRGQEE SAGNSVNYKD 

      1030       1040       1050       1060       1070       1080 
NPKRSNFSSE NDHKKNIQEY NSRDTKRVRE EIIKLSKQNK CNNEYSMEYC TYSDERNSSP 

      1090       1100       1110       1120       1130       1140 
GPCSREERKK LCCQISDYCL KYFNFYSIEY YNCIKSEIKS PEYKCFKSEG QSSIPYFAAG 

      1150       1160       1170       1180       1190       1200 
GILVVIVLLL SSASRMGKSN EEYDIGESNI EATFEENNYL NKLSRIFNQE VQETNISDYS 

      1210 
EYNYNEKNMY 

« Hide

References

[1]"A novel ligand from Plasmodium falciparum that binds to a sialic acid-containing receptor on the surface of human erythrocytes."
Thompson J.K., Triglia T., Reed M.B., Cowman A.F.
Mol. Microbiol. 0:0-0(2002)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: 3D7 EMBL AAL58319.1.
[2]"Crystal and solution structures of Plasmodium falciparum erythrocyte-binding antigen 140 reveal determinants of receptor specificity during erythrocyte invasion."
Lin D.H., Malpede B.M., Batchelor J.D., Tolia N.H.
J. Biol. Chem. 287:36830-36836(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 141-755.
[3]"Molecular basis for sialic acid-dependent receptor recognition by the Plasmodium falciparum invasion protein erythrocyte-binding antigen-140/BAEBL."
Malpede B.M., Lin D.H., Tolia N.H.
J. Biol. Chem. 288:12406-12415(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.00 ANGSTROMS) OF 141-755.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF384554 Genomic DNA. Translation: AAL58319.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4GF2X-ray2.40A141-755[»]
4JNOX-ray3.00A141-755[»]
ProteinModelPortalQ8WS31.
SMRQ8WS31. Positions 143-740, 1049-1127.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR008602. Duffy-antigen_binding.
IPR021620. EBA-175_VI.
[Graphical view]
PfamPF05424. Duffy_binding. 2 hits.
PF11556. EBA-175_VI. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ8WS31_PLAFA
AccessionPrimary (citable) accession number: Q8WS31
Entry history
Integrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: February 19, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)