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Q8WS31

- Q8WS31_PLAFA

UniProt

Q8WS31 - Q8WS31_PLAFA

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Protein
Submitted name: Erythrocyte binding antigen 140
Gene
N/A
Organism
Plasmodium falciparum
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. receptor activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. pathogenesis Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Erythrocyte binding antigen 140Imported
OrganismiPlasmodium falciparumImported
Taxonomic identifieri5833 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiumPlasmodium (Laverania)

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: InterPro
Complete GO annotation...

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4GF2X-ray2.40A141-755[»]
4JNOX-ray3.00A141-755[»]
ProteinModelPortaliQ8WS31.
SMRiQ8WS31. Positions 143-740, 1049-1127.

Family & Domainsi

Family and domain databases

InterProiIPR008602. Duffy-antigen_binding.
IPR021620. EBA-175_VI.
[Graphical view]
PfamiPF05424. Duffy_binding. 2 hits.
PF11556. EBA-175_VI. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8WS31-1 [UniParc]FASTAAdd to Basket

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MKGYFNIYFL IPLIFLYNVI RINESIIGRT LYNRQDESSD ISRVNSPELN     50
NNHKTNIYDS DYEDVNNKLI NSFVENKSVK KKRSLSFINN KTKSYDIIPP 100
SYSYRNDKFN SLSENEDNSG NTNSNNFANT SEISIGKDNK QYTFIQKRTH 150
LFACGIKRKS IKWICRENSE KITVCVPDRK IQLCIANFLN SRLETMEKFK 200
EIFLISVNTE AKLLYNKNEG KDPSIFCNEL RNSFSDFRNS FIGDDMDFGG 250
NTDRVKGYIN KKFSDYYKEK NVEKLNNIKK EWWEKNKANL WNHMIVNHKG 300
NISKECAIIP AEEPQINLWI KEWNENFLME KKRLFLNIKD KCVENKKYEA 350
CFGGCRLPCS SYTSFMKKSK TQMEVLTNLY KKKNSGVDKN NFLNDLFKKN 400
NKNDLDDFFK NEKEYDDLCD CRYTATIIKS FLNGPAKNDV DIASQINVND 450
LRGFGCNYKS NNEKSWNCTG TFTNKFPGTC EPPRRQTLCL GRTYLLHRGH 500
EEDYKEHLLG ASIYEAQLLK YKYKEKDENA LCSIIQNSYA DLADIIKGSD 550
IIKDYYGKKM EENLNKVNKD KKRNEESLKI FREKWWDENK ENVWKVMSAV 600
LKNKETCKDY DKFQKIPQFL RWFKEWGDDF CEKRKEKIYS FESFKVECKK 650
KDCDENTCKN KCSEYKKWID LKKSEYEKQV DKYTKDKNKK MYDNIDEVKN 700
KEANVYLKEK SKECKDVNFD DKIFNESPNE YEDMCKKCDE IKYLNEIKYP 750
KTKHDIYDID TFSDTFGDGT PISINANINE QQSGKDTSNT GNSETSDSPV 800
SHEPESDAAI NVEKLSGDES SSETRGILDI NDPSVTNNVN EVHDASNTQG 850
SVSNTSDITN GHSESSLNRT TNAQDIKIGR SGNEQSDNQE NSSHSSDNSG 900
SLTIGQVPSE DNTQNTYDSQ NPHRDTPNAL ASLPSDDKIN EIEGFDSSRD 950
SENGRGDTTS NTHDVRRTNI VSERRVNSHD FIRNGMANNN AHHQYITQIE 1000
NNGIIRGQEE SAGNSVNYKD NPKRSNFSSE NDHKKNIQEY NSRDTKRVRE 1050
EIIKLSKQNK CNNEYSMEYC TYSDERNSSP GPCSREERKK LCCQISDYCL 1100
KYFNFYSIEY YNCIKSEIKS PEYKCFKSEG QSSIPYFAAG GILVVIVLLL 1150
SSASRMGKSN EEYDIGESNI EATFEENNYL NKLSRIFNQE VQETNISDYS 1200
EYNYNEKNMY 1210
Length:1,210
Mass (Da):140,596
Last modified:March 1, 2002 - v1
Checksum:iFF44FBB8DA69D605
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF384554 Genomic DNA. Translation: AAL58319.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF384554 Genomic DNA. Translation: AAL58319.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4GF2 X-ray 2.40 A 141-755 [» ]
4JNO X-ray 3.00 A 141-755 [» ]
ProteinModelPortali Q8WS31.
SMRi Q8WS31. Positions 143-740, 1049-1127.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR008602. Duffy-antigen_binding.
IPR021620. EBA-175_VI.
[Graphical view ]
Pfami PF05424. Duffy_binding. 2 hits.
PF11556. EBA-175_VI. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A novel ligand from Plasmodium falciparum that binds to a sialic acid-containing receptor on the surface of human erythrocytes."
    Thompson J.K., Triglia T., Reed M.B., Cowman A.F.
    Mol. Microbiol. 0:0-0(2002)
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 3D7Imported.
  2. "Crystal and solution structures of Plasmodium falciparum erythrocyte-binding antigen 140 reveal determinants of receptor specificity during erythrocyte invasion."
    Lin D.H., Malpede B.M., Batchelor J.D., Tolia N.H.
    J. Biol. Chem. 287:36830-36836(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 141-755.
  3. "Molecular basis for sialic acid-dependent receptor recognition by the Plasmodium falciparum invasion protein erythrocyte-binding antigen-140/BAEBL."
    Malpede B.M., Lin D.H., Tolia N.H.
    J. Biol. Chem. 288:12406-12415(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.00 ANGSTROMS) OF 141-755.

Entry informationi

Entry nameiQ8WS31_PLAFA
AccessioniPrimary (citable) accession number: Q8WS31
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: February 19, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3

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