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Q8WS26

- Q8WS26_TRYCR

UniProt

Q8WS26 - Q8WS26_TRYCR

Protein
Submitted name:

Farnesyl diphosphate synthase

Gene
N/A
Organism
Trypanosoma cruzi
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (01 Mar 2002)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei84 – 841Sulfate 1
    Binding sitei204 – 2041Sulfate 1
    Binding sitei204 – 2041Sulfate 3Imported

    GO - Molecular functioni

    1. transferase activity Source: UniProtKB-KW

    GO - Biological processi

    1. isoprenoid biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    TransferaseUniRule annotation

    Keywords - Biological processi

    Isoprene biosynthesisUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Farnesyl diphosphate synthaseImported
    OrganismiTrypanosoma cruziImported
    Taxonomic identifieri5693 [NCBI]
    Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosomaSchizotrypanum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3030 PotentialImportedAdd
    BLAST
    Chaini31 – 425395 PotentialImportedPRO_5000061101Add
    BLAST

    Interactioni

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1YHKX-ray2.10A64-423[»]
    1YHLX-ray1.95A64-425[»]
    1YHMX-ray2.50A/B/C64-425[»]
    ProteinModelPortaliQ8WS26.
    SMRiQ8WS26. Positions 64-425.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ8WS26.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni111 – 1144Sulfate 2 bindingImported

    Sequence similaritiesi

    Belongs to the FPP/GGPP synthase family.UniRule annotation

    Keywords - Domaini

    Transit peptideImported

    Family and domain databases

    Gene3Di1.10.600.10. 1 hit.
    InterProiIPR000092. Polyprenyl_synt.
    IPR008949. Terpenoid_synth.
    [Graphical view]
    PfamiPF00348. polyprenyl_synt. 1 hit.
    [Graphical view]
    SUPFAMiSSF48576. SSF48576. 1 hit.
    PROSITEiPS00723. POLYPRENYL_SYNTHASE_1. 1 hit.
    PS00444. POLYPRENYL_SYNTHASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8WS26-1 [UniParc]FASTAAdd to Basket

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    MTAFACFPHS LFYSTRLPFF FFFFCVCVHC CLRYLCLLKC AYCCSDKNYF    50
    RPLNYFFYCL YLAMASMERF LSVYDEVQAF LLDQLQSKYE IDPNRARYLR 100
    IMMDTTCLGG KYFRGMTVVN VAEGFLAVTQ HDEATKERIL HDACVGGWMI 150
    EFLQAHYLVE DDIMDGSVMR RGKPCWYRFP GVTTQCAIND GIILKSWTQI 200
    MAWHYFADRP FLKDLLCLFQ KVDYATAVGQ MYDVTSMCDS NKLDPEVAQP 250
    MTTDFAEFTP AIYKRIVKYK TTFYTYLLPL VMGLLVSEAA ASVEMNLVER 300
    VAHLIGEYFQ VQDDVMDCFT PPEQLGKVGT DIEDAKCSWL AVTFLGKANA 350
    AQVAEFKANY GEKDPAKVAV VKRLYSKANL QADFAAYEAE VVREVESLIE 400
    QLKVKSPTFA ESVAVVWEKT HKRKK 425
    Length:425
    Mass (Da):48,829
    Last modified:March 1, 2002 - v1
    Checksum:iCCBD1343BE591FB1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF386102 Genomic DNA. Translation: AAL73357.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF386102 Genomic DNA. Translation: AAL73357.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1YHK X-ray 2.10 A 64-423 [» ]
    1YHL X-ray 1.95 A 64-425 [» ]
    1YHM X-ray 2.50 A/B/C 64-425 [» ]
    ProteinModelPortali Q8WS26.
    SMRi Q8WS26. Positions 64-425.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi Q8WS26.
    ChEMBLi CHEMBL4752.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei Q8WS26.

    Family and domain databases

    Gene3Di 1.10.600.10. 1 hit.
    InterProi IPR000092. Polyprenyl_synt.
    IPR008949. Terpenoid_synth.
    [Graphical view ]
    Pfami PF00348. polyprenyl_synt. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48576. SSF48576. 1 hit.
    PROSITEi PS00723. POLYPRENYL_SYNTHASE_1. 1 hit.
    PS00444. POLYPRENYL_SYNTHASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequencing and characterization of a mitochondrial farnesyl diphosphate synthase of Trypanosoma cruzi."
      Ferella M.A., Bontempi E.J.
      Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "Structure and mechanism of the farnesyl diphosphate synthase from Trypanosoma cruzi: implications for drug design."
      Gabelli S.B., McLellan J.S., Montalvetti A., Oldfield E., Docampo R., Amzel L.M.
      Proteins 62:80-88(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 64-425.

    Entry informationi

    Entry nameiQ8WS26_TRYCR
    AccessioniPrimary (citable) accession number: Q8WS26
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 1, 2002
    Last sequence update: March 1, 2002
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3