Q8WS26 (Q8WS26_TRYCR) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Submitted name: Farnesyl diphosphate synthase EMBL AAL73357.1
Organism	Trypanosoma cruzi EMBL AAL73357.1
Taxonomic identifier	5693 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Euglenozoa › Kinetoplastida › Trypanosomatidae › Trypanosoma › Schizotrypanum

Protein attributes

Sequence length	425 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the FPP/GGPP synthase family. RuleBase RU004466

Ontologies

Keywords
Biological process	Isoprene biosynthesis RuleBase RU004466
Domain	Transit peptide EMBL AAL73357.1
Molecular function	Transferase RuleBase RU004466
Technical term	3D-structure PDB 1YHK PDB 1YHM PDB 1YHL
Gene Ontology (GO)
Biological_process	isoprenoid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	transferase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 30	30	Potential EMBL AAL73357.1
	Chain	31 – 425	395	Potential EMBL AAL73357.1		PRO_5000061101

Sequences

	Sequence		Length	Mass (Da)
	Q8WS26 [UniParc]. Last modified March 1, 2002. Version 1. Checksum: CCBD1343BE591FB1	FASTA	425	48,829
	10 20 30 40 50 60 MTAFACFPHS LFYSTRLPFF FFFFCVCVHC CLRYLCLLKC AYCCSDKNYF RPLNYFFYCL 70 80 90 100 110 120 YLAMASMERF LSVYDEVQAF LLDQLQSKYE IDPNRARYLR IMMDTTCLGG KYFRGMTVVN 130 140 150 160 170 180 VAEGFLAVTQ HDEATKERIL HDACVGGWMI EFLQAHYLVE DDIMDGSVMR RGKPCWYRFP 190 200 210 220 230 240 GVTTQCAIND GIILKSWTQI MAWHYFADRP FLKDLLCLFQ KVDYATAVGQ MYDVTSMCDS 250 260 270 280 290 300 NKLDPEVAQP MTTDFAEFTP AIYKRIVKYK TTFYTYLLPL VMGLLVSEAA ASVEMNLVER 310 320 330 340 350 360 VAHLIGEYFQ VQDDVMDCFT PPEQLGKVGT DIEDAKCSWL AVTFLGKANA AQVAEFKANY 370 380 390 400 410 420 GEKDPAKVAV VKRLYSKANL QADFAAYEAE VVREVESLIE QLKVKSPTFA ESVAVVWEKT HKRKK

References

[1]	"Sequencing and characterization of a mitochondrial farnesyl diphosphate synthase of Trypanosoma cruzi." Ferella M.A., Bontempi E.J. Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[2]	"Structure and mechanism of the farnesyl diphosphate synthase from Trypanosoma cruzi: implications for drug design." Gabelli S.B., McLellan J.S., Montalvetti A., Oldfield E., Docampo R., Amzel L.M. Proteins 62:80-88(2006) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 64-425.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF386102 Genomic DNA. Translation: AAL73357.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1YHK	X-ray	2.10	A	64-425	[»]
1YHL	X-ray	1.95	A	64-425	[»]
1YHM	X-ray	2.50	A/B/C	64-425	[»]

ProteinModelPortal

Q8WS26.

SMR

Q8WS26. Positions 64-425.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Family and domain databases

Gene3D

1.10.600.10. 1 hit.

InterPro

IPR000092. Polyprenyl_synt.
IPR008949. Terpenoid_synth.
[Graphical view]

Pfam

PF00348. polyprenyl_synt. 1 hit.
[Graphical view]

SUPFAM

SSF48576. Terpenoid_synth. 1 hit.

PROSITE

PS00723. POLYPRENYL_SYNTHASE_1. 1 hit.
PS00444. POLYPRENYL_SYNTHASE_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

BindingDB

Q8WS26.

ChEMBL

CHEMBL4752.

EvolutionaryTrace

Q8WS26.

Entry information

Entry name

Q8WS26_TRYCR

Accession

Primary (citable) accession number: Q8WS26

Entry history

Integrated into UniProtKB/TrEMBL:	March 1, 2002
Last sequence update:	March 1, 2002
Last modified:	March 6, 2013
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)