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Q8WS26 (Q8WS26_TRYCR) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
OrganismTrypanosoma cruzi EMBL AAL73357.1
Taxonomic identifier5693 [NCBI]
Taxonomic lineageEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosomaSchizotrypanum

Protein attributes

Sequence length425 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the FPP/GGPP synthase family. RuleBase RU004466

Ontologies

Keywords
   Biological processIsoprene biosynthesis RuleBase RU004466
   DomainTransit peptide EMBL AAL73357.1
   Molecular functionTransferase RuleBase RU004466
   Technical term3D-structure PDB 1YHK PDB 1YHM PDB 1YHL
Gene Ontology (GO)
   Biological_processisoprenoid biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functiontransferase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 3030 Potential EMBL AAL73357.1
Chain31 – 425395 Potential EMBL AAL73357.1
PRO_5000061101

Regions

Region111 – 1144Sulfate 2 binding PDB 1YHK

Sites

Binding site841Sulfate 1
Binding site2041Sulfate 1
Binding site2041Sulfate 3 PDB 1YHL

Sequences

Sequence LengthMass (Da)Tools
Q8WS26 [UniParc].

Last modified March 1, 2002. Version 1.
Checksum: CCBD1343BE591FB1

FASTA42548,829
        10         20         30         40         50         60 
MTAFACFPHS LFYSTRLPFF FFFFCVCVHC CLRYLCLLKC AYCCSDKNYF RPLNYFFYCL 

        70         80         90        100        110        120 
YLAMASMERF LSVYDEVQAF LLDQLQSKYE IDPNRARYLR IMMDTTCLGG KYFRGMTVVN 

       130        140        150        160        170        180 
VAEGFLAVTQ HDEATKERIL HDACVGGWMI EFLQAHYLVE DDIMDGSVMR RGKPCWYRFP 

       190        200        210        220        230        240 
GVTTQCAIND GIILKSWTQI MAWHYFADRP FLKDLLCLFQ KVDYATAVGQ MYDVTSMCDS 

       250        260        270        280        290        300 
NKLDPEVAQP MTTDFAEFTP AIYKRIVKYK TTFYTYLLPL VMGLLVSEAA ASVEMNLVER 

       310        320        330        340        350        360 
VAHLIGEYFQ VQDDVMDCFT PPEQLGKVGT DIEDAKCSWL AVTFLGKANA AQVAEFKANY 

       370        380        390        400        410        420 
GEKDPAKVAV VKRLYSKANL QADFAAYEAE VVREVESLIE QLKVKSPTFA ESVAVVWEKT 


HKRKK 

« Hide

References

[1]"Sequencing and characterization of a mitochondrial farnesyl diphosphate synthase of Trypanosoma cruzi."
Ferella M.A., Bontempi E.J.
Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
[2]"Structure and mechanism of the farnesyl diphosphate synthase from Trypanosoma cruzi: implications for drug design."
Gabelli S.B., McLellan J.S., Montalvetti A., Oldfield E., Docampo R., Amzel L.M.
Proteins 62:80-88(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 64-425 IN COMPLEX WITH SULFATE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF386102 Genomic DNA. Translation: AAL73357.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1YHKX-ray2.10A64-423[»]
1YHLX-ray1.95A64-425[»]
1YHMX-ray2.50A/B/C64-425[»]
ProteinModelPortalQ8WS26.
SMRQ8WS26. Positions 64-425.
ModBaseSearch...
MobiDBSearch...

Chemistry

BindingDBQ8WS26.
ChEMBLCHEMBL4752.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.10.600.10. 1 hit.
InterProIPR000092. Polyprenyl_synt.
IPR008949. Terpenoid_synth.
[Graphical view]
PfamPF00348. polyprenyl_synt. 1 hit.
[Graphical view]
SUPFAMSSF48576. SSF48576. 1 hit.
PROSITEPS00723. POLYPRENYL_SYNTHASE_1. 1 hit.
PS00444. POLYPRENYL_SYNTHASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ8WS26.

Entry information

Entry nameQ8WS26_TRYCR
AccessionPrimary (citable) accession number: Q8WS26
Entry history
Integrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: June 11, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)