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Q8WS26

- Q8WS26_TRYCR

UniProt

Q8WS26 - Q8WS26_TRYCR

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Protein
Submitted name:

Farnesyl diphosphate synthase

Gene
N/A
Organism
Trypanosoma cruzi
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei84 – 841Sulfate 1
Binding sitei204 – 2041Sulfate 1
Binding sitei204 – 2041Sulfate 3Imported

GO - Molecular functioni

  1. transferase activity Source: UniProtKB-KW

GO - Biological processi

  1. isoprenoid biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

TransferaseUniRule annotation

Keywords - Biological processi

Isoprene biosynthesisUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Farnesyl diphosphate synthaseImported
OrganismiTrypanosoma cruziImported
Taxonomic identifieri5693 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosomaSchizotrypanum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3030 PotentialImportedAdd
BLAST
Chaini31 – 425395 PotentialImportedPRO_5000061101Add
BLAST

Interactioni

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1YHKX-ray2.10A64-423[»]
1YHLX-ray1.95A64-425[»]
1YHMX-ray2.50A/B/C64-425[»]
ProteinModelPortaliQ8WS26.
SMRiQ8WS26. Positions 64-425.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8WS26.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni111 – 1144Sulfate 2 bindingImported

Sequence similaritiesi

Belongs to the FPP/GGPP synthase family.UniRule annotation

Keywords - Domaini

Transit peptideImported

Family and domain databases

Gene3Di1.10.600.10. 1 hit.
InterProiIPR000092. Polyprenyl_synt.
IPR008949. Terpenoid_synth.
[Graphical view]
PfamiPF00348. polyprenyl_synt. 1 hit.
[Graphical view]
SUPFAMiSSF48576. SSF48576. 1 hit.
PROSITEiPS00723. POLYPRENYL_SYNTHASE_1. 1 hit.
PS00444. POLYPRENYL_SYNTHASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8WS26-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTAFACFPHS LFYSTRLPFF FFFFCVCVHC CLRYLCLLKC AYCCSDKNYF
60 70 80 90 100
RPLNYFFYCL YLAMASMERF LSVYDEVQAF LLDQLQSKYE IDPNRARYLR
110 120 130 140 150
IMMDTTCLGG KYFRGMTVVN VAEGFLAVTQ HDEATKERIL HDACVGGWMI
160 170 180 190 200
EFLQAHYLVE DDIMDGSVMR RGKPCWYRFP GVTTQCAIND GIILKSWTQI
210 220 230 240 250
MAWHYFADRP FLKDLLCLFQ KVDYATAVGQ MYDVTSMCDS NKLDPEVAQP
260 270 280 290 300
MTTDFAEFTP AIYKRIVKYK TTFYTYLLPL VMGLLVSEAA ASVEMNLVER
310 320 330 340 350
VAHLIGEYFQ VQDDVMDCFT PPEQLGKVGT DIEDAKCSWL AVTFLGKANA
360 370 380 390 400
AQVAEFKANY GEKDPAKVAV VKRLYSKANL QADFAAYEAE VVREVESLIE
410 420
QLKVKSPTFA ESVAVVWEKT HKRKK
Length:425
Mass (Da):48,829
Last modified:March 1, 2002 - v1
Checksum:iCCBD1343BE591FB1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF386102 Genomic DNA. Translation: AAL73357.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF386102 Genomic DNA. Translation: AAL73357.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1YHK X-ray 2.10 A 64-423 [» ]
1YHL X-ray 1.95 A 64-425 [» ]
1YHM X-ray 2.50 A/B/C 64-425 [» ]
ProteinModelPortali Q8WS26.
SMRi Q8WS26. Positions 64-425.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi Q8WS26.
ChEMBLi CHEMBL4752.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei Q8WS26.

Family and domain databases

Gene3Di 1.10.600.10. 1 hit.
InterProi IPR000092. Polyprenyl_synt.
IPR008949. Terpenoid_synth.
[Graphical view ]
Pfami PF00348. polyprenyl_synt. 1 hit.
[Graphical view ]
SUPFAMi SSF48576. SSF48576. 1 hit.
PROSITEi PS00723. POLYPRENYL_SYNTHASE_1. 1 hit.
PS00444. POLYPRENYL_SYNTHASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequencing and characterization of a mitochondrial farnesyl diphosphate synthase of Trypanosoma cruzi."
    Ferella M.A., Bontempi E.J.
    Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Structure and mechanism of the farnesyl diphosphate synthase from Trypanosoma cruzi: implications for drug design."
    Gabelli S.B., McLellan J.S., Montalvetti A., Oldfield E., Docampo R., Amzel L.M.
    Proteins 62:80-88(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 64-425.

Entry informationi

Entry nameiQ8WS26_TRYCR
AccessioniPrimary (citable) accession number: Q8WS26
Entry historyi
Integrated into UniProtKB/TrEMBL: March 1, 2002
Last sequence update: March 1, 2002
Last modified: October 29, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3